Water-in-oil Pickering emulsion composition containing readily oxidizable active matter, and preparation method and application of water-in-oil Pickering emulsion composition

Abstract

The invention belongs to the technical field of cosmetics, and provides a water-in-oil Pickering emulsion composition containing an oxidizable active matter, and a preparation method and application thereof. The water-in-oil Pickering emulsion composition provided by the invention comprises the following components: an oil phase which comprises C9-C30 alkane and / or polydimethylsiloxane; an aqueous phase comprising water and a polysaccharide; the organic silicon microspheres comprise polymethylsilsesquioxane microspheres; the oxidizable active matter comprises an oxidizable lipophilic active matter and / or an oxidizable water-soluble active matter. The water-in-oil Pickering emulsion composition provided by the invention has smooth skin feeling and no irritation, not only has good stability of an emulsion system, but also can improve the stability of easily-oxidized lipophilic active matters or easily-oxidized water-soluble active matters compounded in the system and obviously reduce the degradation rate of the easily-oxidized active matters, thereby ensuring the efficacy of cosmetics.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and particularly relates to a water-in-oil Pickering emulsion composition containing easily oxidizable active substances, a preparation method thereof, and applications thereof. Background Art

[0002] In the field of cosmetics, water-in-oil emulsions can balance moisturizing and hydration, and thus are widely used. The application of oil-in-water emulsions is less, mainly because they are unstable and usually have a greasy feel. However, oil-in-water emulsions themselves can isolate oxygen in the air, thereby reducing the degradation of easily oxidizable components. Traditional oil-in-water emulsions use relatively high concentrations of surfactants as emulsifiers, which brings a certain degree of greasiness and irritation; moreover, some small-molecule surfactants used as emulsifiers often have biological toxicity and relatively high prices.

[0003] In recent years, the technology of using ultrafine solid particles as emulsifiers to prepare emulsions has received increasing attention. Pickering et al. have conducted systematic research on such emulsions, and thus such emulsions are also called Pickering emulsions. However, the stability of Pickering emulsions is affected by various factors, such as the properties and concentrations of solid particles, and the properties and contents of the oil phase, etc. It is not easy to obtain a stable Pickering emulsion. Summary of the Invention

[0004] The purpose of the present invention is to provide a water-in-oil Pickering emulsion composition containing easily oxidizable active substances, a preparation method thereof, and applications in cosmetics. According to the technical solutions disclosed by the present invention, a water-in-oil emulsion with high stability, smooth feel, and no irritation can be obtained.

[0005] To achieve the above purpose, the present invention adopts the following technical solutions:

[0006] The first aspect of the present invention provides a water-in-oil Pickering emulsion composition containing easily oxidizable active substances, comprising the following components: oil phase: comprising C9-C30 alkanes and / or polydimethylsiloxane; water phase: comprising water and polysaccharides; organosilica microspheres: comprising polymethylsilsesquioxane microspheres; easily oxidizable active substances: comprising easily oxidizable lipophilic active substances and / or easily oxidizable water-soluble active substances; based on the total mass of the water-in-oil Pickering emulsion composition, the total content of the C9-C30 alkanes and / or polydimethylsiloxane is 15-50 wt%; the content of the polysaccharides is 0.01-0.5 wt%; the content of the polymethylsilsesquioxane microspheres is 1-7 wt%; the content of the easily oxidizable active substances is 0.001-10 wt%.

[0007] Preferably, in the water-in-oil Pickering emulsion composition containing easily oxidizable active substances provided by the present invention, the C9-C30 alkanes include one or more of squalane, liquid paraffin, hydrogenated polyisobutene, and isoparaffin.

[0008] Preferably, in the water-in-oil Pickering emulsion composition containing easily oxidizable active substances provided by the present invention, the particle size range of the polymethylsilsesquioxane microspheres is 2 to 5 micrometers.

[0009] Preferably, in the water-in-oil Pickering emulsion composition containing easily oxidizable active substances provided by the present invention, the easily oxidizable active substances include one or more of ascorbic acid and its derivatives, glutathione, polyphenolic compounds, retinol and its derivatives, tocopherol and its derivatives, and astaxanthin.

[0010] Preferably, in the water-in-oil Pickering emulsion composition containing easily oxidizable active substances provided by the present invention, the polysaccharide includes one or more of xanthan gum, scleroglucan, hydrolyzed scleroglucan, and carrageenan.

[0011] More preferably, in the water-in-oil Pickering emulsion composition containing easily oxidizable active substances provided by the present invention, the polysaccharide includes scleroglucan and / or hydrolyzed scleroglucan, and the easily oxidizable active substances include ascorbic acid and its derivatives.

[0012] Preferably, in the water-in-oil Pickering emulsion composition containing easily oxidizable active substances provided by the present invention, the aqueous phase further includes one or more of a humectant, a thickener, a preservative, and a colorant.

[0013] The second aspect of the present invention provides a preparation method of the water-in-oil Pickering emulsion composition containing easily oxidizable active substances according to the first aspect of the present invention, including the following steps:

[0014] (1) Prepare an oil phase, disperse organosilica microspheres in the oil phase, mix evenly, and dissolve the easily oxidizable lipophilic active substances in the oil phase; (2) Prepare an aqueous phase, and dissolve the easily oxidizable water-soluble active substances in the aqueous phase; (3) Under stirring, slowly add the composition obtained in step (2) to the composition obtained in step (1), mix evenly, and form a water-in-oil Pickering emulsion composition containing easily oxidizable active substances.

[0015] The third aspect of the present invention provides a cosmetic, which includes the water-in-oil Pickering emulsion composition containing easily oxidizable active substances according to the first aspect of the present invention.

[0016] Compared with the prior art, the present invention provides a water-in-oil Pickering emulsion composition, which uses polymethylsilsesquioxane microspheres to replace traditional emulsifiers and is compounded with an oil phase containing C9-C30 alkanes and / or polydimethylsiloxane and an aqueous phase containing polysaccharides. A stable water-in-oil Pickering emulsion system is obtained through a simple stirring step. Since the use of surfactants as emulsifiers is avoided, the obtained water-in-oil Pickering emulsion system has a smooth skin feel and no irritation. Moreover, the present invention also compounds an easily oxidizable lipophilic active substance and / or an easily oxidizable water-soluble active substance in the water-in-oil Pickering emulsion system. The Pickering emulsion system provided by the present invention can improve the stability of the easily oxidizable lipophilic active substance and the easily oxidizable water-soluble active substance compounded therewith. Therefore, in cosmetics using the Pickering emulsion system provided by the present invention, the effective content of the easily oxidizable lipophilic active substance and / or the easily oxidizable water-soluble active substance is higher, and the efficacy can be better guaranteed. Detailed Embodiments

[0017] To make the objectives, technical solutions and advantages of the present invention clearer, the embodiments of the present invention will be described in detail below. However, those of ordinary skill in the art can understand that in the embodiments of the present invention, many technical details are provided for the readers to better understand the present application. However, even without these technical details and various changes and modifications based on the following embodiments, the technical solutions claimed in each claim of the present application can still be implemented.

[0018] According to the first aspect of the present application, an embodiment of the present application provides a water-in-oil Pickering emulsion composition containing an easily oxidizable active substance, which comprises the following components: an oil phase: containing C9-C30 alkanes and / or polydimethylsiloxane; an aqueous phase: containing water and polysaccharides; organosilicon microspheres: containing polymethylsilsesquioxane microspheres; easily oxidizable active substances: containing easily oxidizable lipophilic active substances and / or easily oxidizable water-soluble active substances; based on the total mass of the water-in-oil Pickering emulsion composition, the total content of the C9-C30 alkanes and / or polydimethylsiloxane microspheres is 15-50 wt%; the content of the polysaccharides is 0.01-0.5 wt%; the content of the polymethylsilsesquioxane is 1-7 wt%; the content of the easily oxidizable active substances is 0.001-10 wt%.

[0019] In the prior art, traditional water-in-oil emulsions use surfactants as emulsifiers, which brings a certain degree of greasiness and irritation; and some small-molecule surfactants used as emulsifiers have certain biological toxicity. In the process of preparing the water-in-oil emulsion of the present application, the practice of using surfactants is abandoned, and ultrafine solid particles are used as emulsifiers to prepare Pickering emulsions, so that the prepared water-in-oil Pickering emulsion has a smooth skin feel and no irritation. However, the stability of the Pickering emulsion system is a key technical problem to be solved; the stability of the Pickering emulsion system is affected by multiple factors, such as the properties and concentrations of solid particles, and the properties and contents of the oil phase. In the prior art, it is often not easy to obtain a Pickering emulsion with good stability.

[0020] In view of this, the present invention provides a water-in-oil Pickering emulsion composition with relatively high stability. Specifically, polymethylsilsesquioxane microspheres are used to replace traditional emulsifiers, and are compounded with an oil phase containing C9-C30 alkanes and / or polydimethylsiloxane and an aqueous phase containing polysaccharides, and a stable water-in-oil Pickering emulsion system is obtained through a simple stirring step. In the water-in-oil Pickering emulsion system of the present invention, the polymethylsilsesquioxane microspheres play the roles of emulsification and stabilization: the polymethylsilsesquioxane microspheres are hydrophobic and can spontaneously adsorb at the oil / water interface to form a physical barrier at the oil / water interface, preventing the oil droplets in the emulsion from merging with each other, thereby stabilizing the emulsion. At the same time, the oil phase and aqueous phase components provide support and promotion for the emulsification and stabilization effects of the polymethylsilsesquioxane microspheres: the C9-C30 alkanes and / or polydimethylsiloxane in the oil phase have appropriate polarities and have good compatibility with the polymethylsilsesquioxane microspheres, further improving the stability of the polymethylsilsesquioxane microspheres adsorbed at the oil / water interface; the polysaccharides in the aqueous phase can interact with the polymethylsilsesquioxane microspheres through hydrogen bonds and van der Waals forces, further enhancing the adsorption ability of the polymethylsilsesquioxane microspheres at the oil-water interface.

[0021] Moreover, the present invention also compounds easily oxidized lipophilic active substances and easily oxidized water-soluble active substances in the water-in-oil Pickering emulsion system, and improves the stability of the easily oxidized lipophilic active substances and / or easily oxidized water-soluble active substances compounded therewith through the water-in-oil Pickering emulsion system. On the one hand, in the water-in-oil Pickering emulsion system of the present invention, the continuous-phase oil isolates oxygen in the air, thereby reducing the oxidative decomposition of water-soluble active substances; on the other hand, the dispersed-phase particle size of the water-in-oil Pickering emulsion system of the present invention is relatively larger and the oil-water contact area is relatively smaller, thereby reducing the oxidative decomposition of oil-soluble active substances. Therefore, in cosmetics using the water-in-oil Pickering emulsion system of the present invention, the effective contents of the easily oxidized lipophilic active substances and / or easily oxidized water-soluble active substances are higher, and the efficacy can be better guaranteed.

[0022] In some embodiments of the present application, the C9-C30 alkane includes one or more of squalane, liquid paraffin, hydrogenated polyisobutene, and isoparaffin.

[0023] In some embodiments of the present application, the polydimethylsiloxane is selected from linear polydimethylsiloxane and / or cyclic polydimethylsiloxane.

[0024] In some embodiments of the present application, the particle size range of the polymethylsilsesquioxane microspheres is 2 to 5 microns. The particle size of the polymethylsilsesquioxane microspheres can affect the stability of the Pickering emulsion system, and thus also affect the stability of the oxidizable active substances compounded in the system. In the present invention, using organosilicon microspheres with a particle size range of 2 to 5 microns is most beneficial for improving the stability of the water-in-oil Pickering emulsion system and reducing the degradation rate of oxidizable active substances.

[0025] In some embodiments of the present application, the oxidizable active substances include one or more of ascorbic acid and its derivatives, glutathione, polyphenolic compounds, retinol and its derivatives, tocopherol and its derivatives, and astaxanthin.

[0026] In some embodiments of the present application, the polysaccharide includes one or more of xanthan gum, scleroglucan, hydrolyzed scleroglucan, and carrageenan.

[0027] In some embodiments of the present application, the polysaccharide includes scleroglucan and / or hydrolyzed scleroglucan, and the oxidizable active substance includes ascorbic acid and its derivatives. The inventors of the present application surprisingly found that, compared with other polysaccharides (such as xanthan gum, etc.), using scleroglucan and / or hydrolyzed scleroglucan in the present invention has a better effect on improving the stability of ascorbic acid and its derivatives compounded in the Pickering system.

[0028] In some embodiments of the present application, the aqueous phase further includes one or more of a humectant, a thickener, a preservative, and a colorant. The present application does not limit the specific selection of the above humectant, thickener, preservative, colorant or other conventional components in cosmetics. As an example, the optional humectant can be glycerol, etc., and the optional thickener can be sodium carbomer, etc.

[0029] According to the second aspect of the present invention, an embodiment of the present application further provides a method for preparing a water-in-oil Pickering emulsion composition containing an easily oxidizable active substance according to the first aspect of the present invention, comprising the following steps: (1) preparing an oil phase, dispersing silicone microspheres in the oil phase, mixing evenly, and dissolving the easily oxidizable lipophilic active substance in the oil phase; (2) preparing an aqueous phase, dissolving the easily oxidizable water-soluble active substance in the aqueous phase; (3) under stirring, slowly adding the composition obtained in step (2) to the composition obtained in step (1), mixing evenly to form a water-in-oil Pickering emulsion composition containing an easily oxidizable active substance.

[0030] According to the third aspect of the present invention, an embodiment of the present application further provides a cosmetic, which comprises the water-in-oil Pickering emulsion composition containing an easily oxidizable active substance according to the first aspect of the present invention. Since the water-in-oil Pickering emulsion composition containing an easily oxidizable active substance according to the first aspect of the present invention has good stability and can reduce the oxidative decomposition of the easily oxidizable lipophilic active substance and the easily oxidizable water-soluble active substance compounded in the system, the cosmetic provided by the embodiment of the present application not only has good stability, but also has a high effective content of the active substance, thereby obtaining better efficacy.

[0031] The advantages of the present application are further illustrated below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present application and not to limit the scope of the present application.

[0032] Examples 1 to 11

[0033] Prepare the Pickering emulsion composition according to the following steps:

[0034] (1) Prepare an oil phase, disperse silicone microspheres in the oil phase, mix evenly, and dissolve the easily oxidizable lipophilic active substance in the aforementioned oil phase;

[0035] (2) Prepare an aqueous phase, dissolve the easily oxidizable water-soluble active substance in the aqueous phase;

[0036] (3) Under stirring, slowly add the aqueous phase composition obtained in step (2) to the oil phase composition obtained in step (1), mix evenly to form a water-in-oil Pickering emulsion composition containing an easily oxidizable active substance.

[0037] The specific components, parameters, and contents of the water-in-oil Pickering emulsions prepared in Examples 1 to 11 are shown in Table 1.

[0038] Comparative Example 1

[0039] Comparative Example 1 only contains the water-soluble active substances ascorbic acid, glycerin, hydrolyzed sclerotium gum, and water. The specific components and contents are shown in Table 2.

[0040] Comparative Examples 2 to 4

[0041] Comparative Examples 2 to 4 did not contain any solid particle components, but used the surfactant PEG-10 polydimethylsiloxane as an emulsifier to prepare a conventional water-in-oil emulsion, not a Pickering water-in-oil emulsion. The specific components and contents are shown in Table 2.

[0042] Comparative Example 5

[0043] Although Comparative Example 5 used polymethylsilsesquioxane microspheres to prepare a Pickering water-in-oil emulsion, the content was only 0.5%. The other components and contents are shown in Table 2.

[0044] Comparative Examples 6 to 7

[0045] Comparative Examples 6 and 7 used starch microspheres and another silicone microsphere, vinyl polydimethylsiloxane cross-linked polymer microspheres, respectively, to replace the polymethylsilsesquioxane microspheres to prepare a Pickering water-in-oil emulsion. The specific components and contents are shown in Table 2.

[0046] Comparative Example 8

[0047] Comparative Example 8 used tricaprylin / capric acid as the oil phase component to prepare a Pickering water-in-oil emulsion. The specific components and contents are shown in Table 2.

[0048] Comparative Examples 9, 10

[0049] The only difference between Comparative Examples 9 and 10 and Example 6 was that the particle size of the polymethylsilsesquioxane microspheres used was 8 μm and 10 μm.

[0050] Detection:

[0051] The emulsions prepared in Examples 1 to 11 and Comparative Examples 1 to 10 were detected as follows:

[0052] 1. Stability observation:

[0053] Visually observe whether a stable Pickering emulsion system can be formed: If phenomena such as stratification and coalescence occur, a stable Pickering emulsion system has not been formed. (Note: Among them, Comparative Examples 1-4 did not contain any solid particle components, and they were not Pickering emulsion systems).

[0054] 2. Detection of the degradation rate of easily oxidized active substances:

[0055] (1) Degradation rate of ascorbic acid

[0056] Detection method for ascorbic acid content: HPLC method, C18 reverse-phase chromatographic column, ultraviolet-visible detector, detection wavelength 325 nm, mobile phase: methanol / water = 85 / 15, internal standard method, flow rate 1 mL / min, column temperature 25 °C.

[0057] Degradation rate of ascorbic acid =

(A 0 -A1 ) / A 0

[0058] Wherein, A 0 is the ascorbic acid content at the completion of preparation (T0 time point); A 1 is the ascorbic acid content after stability test (one week at 60°C).

[0059] (2) Degradation rate of retinol palmitate

[0060] Detection method for retinol palmitate content: HPLC method, C18 reversed-phase chromatographic column, ultraviolet-visible detector, detection wavelength 254 nm, mobile phase: water / methanol = 90 / 10, internal standard method, flow rate 1 mL / min, column temperature 30°C.

[0061] Degradation rate of retinol palmitate =

(B 0 - B 1 ) / B 0

[0062] Wherein, B 0 is the retinol palmitate content at the completion of preparation (T0 time point); B 1 is the retinol palmitate content after stability test (one week at 60°C).

[0063] The stability observation results and the detection data of the degradation rate of easily oxidized active substances for Examples 1 to 11 and Comparative Examples 1 to 10 are respectively recorded in Table 1 and Table 2.

[0064] Table 1 Components and Contents, Detection Results of Examples 1 to 11

[0065]

[0066] Table 2 Components and Contents, Detection Results of Comparative Examples 1 to 10

[0067]

[0068] Examples 1 to 11 prepared water-in-oil Pickering emulsion compositions according to the technical solutions provided by the present invention. Polymethylsilsesquioxane microspheres were used to replace traditional emulsifiers and were compounded with an oil phase containing C9-C30 alkanes and / or polydimethylsiloxane and an aqueous phase containing polysaccharides. An easily oxidizable active substance, ascorbic acid or retinyl palmitate, was also compounded in the water-in-oil Pickering emulsion system. A stable water-in-oil Pickering emulsion system was obtained through a simple stirring step. Since the use of surfactants as emulsifiers was avoided, the obtained water-in-oil Pickering emulsion system also had a smooth skin feel and no irritation. After testing, the degradation of the easily oxidizable active substances ascorbic acid or retinyl palmitate in Examples 1 to 11 was effectively controlled, indicating that the water-in-oil Pickering emulsion system provided by this application could improve the stability of easily oxidizable active substances. Therefore, the efficacy of cosmetics using the water-in-oil Pickering emulsion compositions of Examples 1 to 11 could be better guaranteed.

[0069] Among Examples 1 to 11, in Examples 1 to 6, scleroglucan was used after hydrolysis. Compared with Examples 10 to 11 using xanthan gum, the effect of reducing the degradation rate of ascorbic acid was more significant, proving that compared with other polysaccharides, the use of scleroglucan and / or hydrolyzed scleroglucan in the present invention had an obviously better effect on improving the stability of ascorbic acid and its derivatives compounded in the water-in-oil Pickering system.

[0070] Comparative Example 1 only contained the water-soluble active substance ascorbic acid, glycerol, hydrolyzed scleroglucan and water, and was a non-emulsion system; Comparative Examples 2 to 4 used the surfactant PEG-10 polydimethylsiloxane as an emulsifier to prepare a traditional water-in-oil emulsion system, which was a non-Pickering emulsion system. The degradation rates of the easily oxidizable active substances in Comparative Examples 1 to 4 were relatively high, which had an adverse effect on the efficacy of cosmetics. The comparison of the degradation rate data of the easily oxidizable active substances in Comparative Examples 1 to 4 and Examples 1 to 11 could fully illustrate that compared with the non-emulsion system and the traditional water-in-oil emulsion system, the water-in-oil Pickering emulsion system provided by this application could significantly improve the stability of the easily oxidizable active substances compounded with it.

[0071] Although Pickering emulsions were prepared using polymethylsilsesquioxane microspheres in Comparative Example 5, the content was only 0.5%, and its emulsifying and stabilizing effects could not be effectively exerted; in Comparative Examples 6 and 7, starch microspheres and vinyl polydimethylsiloxane cross-linked polymer microspheres were used to replace polymethylsilsesquioxane microspheres in an attempt to prepare Pickering emulsions; in Comparative Example 8, tricaprylin was used as the oil phase component to prepare a Pickering emulsion. Stratification, coalescence and other phenomena occurred in Comparative Examples 5 to 8, and a stable Pickering emulsion system could not be formed, nor could the degradation of the oxidation-active substances be effectively inhibited. It can be seen that in the technical solution provided by this application, the selection of the type and dosage of polymethylsilsesquioxane microspheres and the selection of the oil phase component play a key role in achieving the technical effects of this application.

[0072] The differences between Comparative Examples 9 and 10 and Example 6 are only that the particle sizes of the polymethylsilsesquioxane microspheres used are 8 μm or 10 μm. From the comparison of the test results of Comparative Examples 9-10 and Example 6, it can be seen that the particle size of the polymethylsilsesquioxane microspheres also has an important influence on the stability of the Pickering emulsion system. Polymethylsilsesquioxane microspheres with too large particle sizes cannot be used to prepare a stable Pickering emulsion system, nor can they improve the stability of easily oxidized active substances. The silicone microspheres with a particle size range of 2-5 μm used in this application are most beneficial for forming a stable Pickering emulsion system and improving the stability of the easily oxidized active substances in the Pickering emulsion system.

[0073] Those of ordinary skill in the art can understand that the above embodiments are specific examples for implementing the present invention, and in practical applications, various changes can be made to them in form and details without departing from the spirit and scope of the present invention.

Claims

1. A water-in-oil Pickering emulsion composition containing an oxidizable active ingredient, characterized in that: Contains the following components: Oil phase: containing C9-C30 alkanes and / or polydimethylsiloxane; Aqueous phase: contains water and polysaccharides; Silicone microspheres: containing polymethylsilsesquioxane microspheres; Easily oxidizable active ingredients: including easily oxidizable lipophilic active ingredients and / or easily oxidizable water-soluble active ingredients; Based on the total mass of the water-in-oil Pickering emulsion composition, the total content of the C9-C30 alkane and / or polydimethylsiloxane is 15 to 50 wt %; the content of the polysaccharide is 0.01 to 0.5 wt %; the content of the polymethylsilsesquioxane microspheres is 1 to 7 wt %; and the content of the easily oxidizable active substance is 0.001 to 10 wt %.

2. The water-in-oil Pickering emulsion composition containing an oxidizable active ingredient according to claim 1, characterized in that: The C9-C30 alkane includes one or more of squalane, liquid paraffin, hydrogenated polyisobutylene, and isomeric paraffin.

3. The water-in-oil Pickering emulsion composition containing an oxidizable active ingredient according to claim 1, characterized in that: The particle size of the polymethylsilsesquioxane microspheres is in the range of 2 to 5 microns.

4. The water-in-oil Pickering emulsion composition containing an oxidizable active ingredient according to claim 1, characterized in that: The oxidizable active substances include one or more of ascorbic acid and its derivatives, glutathione, polyphenol compounds, retinol or its derivatives, tocopherol or its derivatives, and astaxanthin.

5. The water-in-oil Pickering emulsion composition containing an oxidizable active ingredient according to claim 1, characterized in that: The polysaccharide comprises one or more of xanthan gum, sclerotium gum, hydrolyzed sclerotium gum and carrageenan.

6. The water-in-oil Pickering emulsion composition containing an oxidizable active ingredient according to claim 1, characterized in that: The polysaccharide comprises sclerotium gum and / or hydrolyzed sclerotium gum, and the oxidizable active substance comprises ascorbic acid or its derivatives.

7. The water-in-oil Pickering emulsion composition containing an oxidizable active ingredient according to claim 1, characterized in that: The water phase further comprises one or more of a moisturizer, a thickener, a preservative, and a colorant.

8. A method for preparing a water-in-oil Pickering emulsion composition containing an oxidizable active ingredient according to any one of claims 1 to 7, comprising the following steps: (1) preparing an oil phase, dispersing the organosilicon microspheres in the oil phase, mixing evenly, and dissolving the easily oxidizable lipophilic active substance in the oil phase; (2) preparing an aqueous phase and dissolving the easily oxidizable water-soluble active substance in the aqueous phase; (3) Under stirring, slowly add the composition obtained in step (2) to the composition obtained in step (1), mix them evenly, and form a water-in-oil Pickering emulsion composition containing the easily oxidizable active ingredient.

9. Use of the water-in-oil Pickering emulsion composition comprising an oxidizable active ingredient according to any one of claims 1 to 7 in the preparation of cosmetics.

10. A cosmetic, characterized in that: A water-in-oil Pickering emulsion composition comprising an oxidizable active substance according to any one of claims 1 to 7.

Images