Soothing and acne-removing cosmetic composition as well as preparation method and application thereof

Abstract

The invention belongs to the field of cosmetics, and particularly discloses a soothing and acne-removing cosmetic composition as well as a preparation method and application thereof. The cosmetic composition comprises a phase A, a phase B, a phase C and a phase D, the phase A comprises an emollient and a powder dispersant; the phase B comprises an emollient and an active component; the phase C comprises a thickening agent, an emulsifying agent, an emollient, a film-forming agent and a skin feeling conditioning agent; the phase D comprises water, a humectant, an antioxidant, an anti-freezing agent and a thickening agent; the active ingredients comprise at least one of tamanu oil, ceramide NP, heparinoid sodium, a glycyrrhiza inflate extract and licochalcone A. The cosmetic composition is good in stability and good in moisturizing, soothing and acne removing effects, and has an unexpected synergistic technical effect.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and particularly to a soothing acne-removing cosmetic composition, a preparation method thereof and an application thereof. Background Art

[0002] Acne, often referred to as pimples or zits, is a chronic skin inflammatory disease. It mostly occurs on the face, upper chest, back and other parts, and its clinical manifestations are diverse, including symptoms such as comedones, papules, pustules, nodules, etc. The main pathogenesis involves the following key factors: one is excessive sebum secretion; the second is the blockage of the hair follicle sebaceous gland duct; the third is bacterial infection, especially the invasion of Propionibacterium acnes; the fourth is the occurrence of inflammatory reactions. Since acne is extremely common in adolescence, it is also commonly known as "adolescent acne". However, "adolescent acne" is not exclusive to adolescence. In daily life, the skin is easily exposed to the air for a long time, which is extremely likely to adsorb dust, thereby causing blockage of skin pores. At the same time, factors such as the influence of computer radiation and unhealthy living schedules will interfere with the skin barrier function of the human body and break the original metabolic law of the skin, all of which may become the inducements for the growth of acne.

[0003] Currently, there are a variety of anti-acne methods. Taking laser treatment as an example, it can quickly destroy Propionibacterium acnes, effectively inhibit bacterial reproduction, and reduce the irritation and damage to tissues. However, the effect of laser treatment is too strong, and it cannot solve the problem of acne growth from the root cause. There is also fruit acid therapy, which has a certain inhibitory effect on acne, but its irritation is large and the side effects are obvious. Using antibiotic treatment, although the effect can be seen quickly, it is easy to cause drug resistance problems, and long-term use may even lead to skin-dependent dermatitis.

[0004] In contrast, using anti-acne products such as anti-acne creams, anti-acne essences, anti-acne gels, anti-acne masks, etc. for anti-acne has significant advantages. These products are mild in nature, do not cause irritation, and have good effects. Therefore, the research and development of anti-acne products have always attracted much attention.

[0005] Due to their safety, mildness and other advantages, natural extracts are highly favored in anti-acne cosmetics, but such products have problems such as relatively poor anti-acne effects and difficulty in effectively treating acne.

[0006] The skin itself has hydrophobic properties, and its stratum corneum lipid barrier is more compatible with oil-soluble components. Lipid-soluble active substances can directly penetrate into the deep layer of the skin through the lipid bilayer structure, while water-soluble components usually stay on the skin surface or are promoted to be absorbed through auxiliary penetrants due to polarity differences. Some lipid-soluble active ingredients need to be in an oil-soluble form to maintain stability and biological activity. In addition, oil-soluble carriers (such as micro-liposomes) can release active substances to the target skin layer directionally, improving the efficacy. However, due to problems such as difficult dissolution, easy precipitation, and poor component compatibility of lipid solubility, it particularly affects the stability of the W / O formula.

[0007] Therefore, there is still an urgent need for an acne treatment product with good stability, safety, mildness, soothing effect and excellent acne treatment effect. Summary of the Invention

[0008] To solve the above technical problems, through a large number of screenings and investigations on the combination of active ingredients, the present invention unexpectedly discovers that when tamanu oil, ceramide NP, heparinoid sodium and extract of Glycyrrhiza inflata Bat. or licorinchalcone A exist simultaneously, they have unexpected synergistic technical effects. In addition, the present invention conducts a large number of screenings and investigations on the excipients in the present invention, especially on the types of thickeners and emulsifiers in Phase C. Finally, it is found that compared with other types of thickeners, using lithium magnesium silicate as the thickener in Phase C is more conducive to improving the stability of the obtained cosmetic composition; compared with other types of emulsifiers, using at least one of cetyl PEG / PPG-10 / 1 dimethicone and lauryl PEG-9 dimethicone copolyol as the emulsifier in Phase C, especially using both cetyl PEG / PPG-10 / 1 dimethicone and lauryl PEG-9 dimethicone copolyol as the emulsifier in Phase C, is more conducive to improving the stability of the obtained cosmetic composition.

[0009] In the first aspect, the present invention provides a cosmetic composition.

[0010] A cosmetic composition, comprising: Phase A, Phase B, Phase C and Phase D; Phase A comprises an emollient and a powder dispersant; Phase B comprises an emollient and an active ingredient; Phase C comprises a thickener, an emulsifier, an emollient, a film-forming agent and a skin feel regulator; Phase D comprises water, a humectant, an antioxidant, an antifreeze and a thickener; The active ingredient comprises at least one of tamanu oil, ceramide NP, heparinoid sodium, extract of Glycyrrhiza inflata Bat. and licorinchalcone A.

[0011] Tamanu oil contains a large amount of unsaturated fatty acids such as linoleic acid and linolenic acid, which can form a protective layer on the skin surface, inhibit water loss, and thus improve the skin's moisture retention ability. It can promote cell metabolism and regeneration, repair damaged cells, accelerate wound healing, reduce skin inflammation and redness, and soothe the skin. It can accelerate the metabolism of skin cells and make the skin more shiny.

[0012] Ceramide NP is composed of sphingosine and long-chain fatty acids bonded by amide bonds. It is synthesized and secreted by lamellar bodies and can repair damaged skin barrier function by increasing skin hydration and reducing transepidermal water loss. Ceramide NP can connect lipid matrix and keratinocytes, reduce harmful substances from entering the skin through pores and sweat glands, and thus has anti-allergic effects. Ceramide NP can inhibit the occurrence of cell apoptosis in inflammatory reactions and reduce the damage of inflammatory reactions to tissue structures. For sensitive skin, supplementing with ceramide NP can help repair red blood streaks and avoid the occurrence of sensitive phenomena.

[0013] Heparin sodium is a natural sulfonic mucopolysaccharide formed by sulfonation of glycosaminoglycans. Its active function is similar to heparin sodium, so it is called heparin sodium. Heparin sodium can effectively accelerate blood microcirculation, promote the supply of cell nutrients, improve the environment in which cells live, speed up the transportation and discharge of cell metabolic waste, and regulate skin conditions. Therefore, it has the effects of anti-coagulation, removing red blood, soothing, promoting the regeneration of normal connective tissue, promoting smooth and flat skin, and long-term moisturizing.

[0014] Glycyrrhiza inflata extract achieves anti-inflammatory effects by inhibiting phosphodiesterase 4 (PDE4), helping people with atopic skin to survive the acute sensitive period. It can inhibit inflammatory factors (TNF-α↓, IL-2↓, IL-6↓, IL-1β↓, iNOs↓, MCP-1↓, PGE2↓, COX-2↓, NO↓, NFκB↓, IFNγ↓), scavenge free radicals such as ROS, and protect against oxidative damage caused by external stimuli.

[0015] In some embodiments, the emollient in Phase A comprises dimethicone.

[0016] In some embodiments, the powder dispersant in the phase A includes at least one of lauryl polyglyceryl-3 polydimethylsiloxyethyl polydimethylsiloxane and polyhydroxystearic acid, preferably lauryl polyglyceryl-3 polydimethylsiloxyethyl polydimethylsiloxane.

[0017] In some embodiments, the emollient in phase B includes at least one of triethylhexyl glyceryl and diisostearyl malate.

[0018] In some embodiments, the thickener in the phase C includes at least one of disteardimethylammonium hectorite and quaternary ammonium salt-18 bentonite, preferably disteardimethylammonium hectorite.

[0019] In some embodiments, the emulsifier in phase C includes at least one of cetyl PEG / PPG-10 / 1 dimethicone and lauryl PEG-9 polydimethylsiloxyethyl dimethicone.

[0020] In some embodiments, the film-forming agent in the C phase comprises trimethylsiloxysilicate.

[0021] In some embodiments, the skin feel regulator in the C phase comprises at least one of silica and silica powder.

[0022] In some embodiments, the humectant in the D phase comprises at least one of glycerol, 1,3-butanediol, and 1,2-hexanediol.

[0023] In some embodiments, the thickener in the D phase comprises xanthan gum.

[0024] In some embodiments, the antioxidant comprises at least one of hydroxyacetophenone and raspberry ketone.

[0025] In some embodiments, the antifreeze agent comprises at least one of sodium chloride and magnesium sulfate.

[0026] In some embodiments, the active ingredients comprise Calophyllum inophyllum oil, ceramide NP, heparin sodium, and at least one selected from Glabrousfruit Licorice Root Extract and Licoricidin.

[0027] In some embodiments, the powder dispersant in the A phase is lauryl polyglyceryl-3 polydimethylsiloxyethyl polydimethylsiloxane.

[0028] In some embodiments, the emollient in the A phase is polydimethylsiloxane.

[0029] In some embodiments, the emollient in the B phase is triglyceride (ethylhexyl ester).

[0030] In some embodiments, the emulsifiers in the C phase are cetyl PEG / PPG-10 / 1 polydimethylsiloxane and lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane.

[0031] In some embodiments, the film-forming agent in the C phase is trimethylsiloxysilicate.

[0032] In some embodiments, the humectants in the D phase are glycerol, 1,3-butanediol, and 1,2-hexanediol.

[0033] In some embodiments, the thickener in the D phase is xanthan gum.

[0034] In some embodiments, the antioxidant is hydroxyacetophenone.

[0035] In some embodiments, the antifreeze agent is sodium chloride.

[0036] In some embodiments, the A phase further comprises a colorant.

[0037] In some embodiments, the colorant comprises titanium dioxide and / or iron oxide.

[0038] In some embodiments, the titanium dioxide comprises CI 77891.

[0039] In some embodiments, the iron oxide comprises at least one of CI 77492, CI 77491, and CI 77499.

[0040] In some embodiments, based on the total mass of the cosmetic composition, the total content of the colorant in phase A is 9 wt% - 13 wt%. In some embodiments, based on the total mass of the cosmetic composition, the total content of the colorant in phase A is 9 wt%, 10 wt%, 11 wt%, 12 wt%, or 13 wt%.

[0041] In some embodiments, based on the total mass of the cosmetic composition, the content of the emollient in phase A is 4 wt% - 7 wt%. In some embodiments, based on the total mass of the cosmetic composition, the content of the emollient in phase A is 4 wt%, 5 wt%, 6 wt%, or 7 wt%.

[0042] In some embodiments, based on the total mass of the cosmetic composition, the content of the powder dispersant in phase A is 0.5 wt% - 1.5 wt%. In some embodiments, based on the total mass of the cosmetic composition, the content of the powder dispersant in phase A is 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1.0 wt%, or 1.5 wt%.

[0043] In some embodiments, based on the total mass of the cosmetic composition, the total content of the active ingredient is 0.010 wt% - 1.100 wt%. In some embodiments, based on the total mass of the cosmetic composition, the total content of the active ingredient is 0.010 wt%, 0.017 wt%, 0.020 wt%, 0.100 wt%, 0.200 wt%, 0.300 wt%, 0.400 wt%, 0.500 wt%, 0.550 wt%, 0.600 wt%, 0.700 wt%, 0.800 wt%, 0.900 wt%, 1.000 wt%, or 1.100 wt%.

[0044] In some embodiments, based on the total mass of the cosmetic composition, the content of the emollient in phase B is 2 wt% - 3 wt%. In some embodiments, based on the total mass of the cosmetic composition, the content of the emollient in phase B is 2 wt%, 2.5 wt%, or 3 wt%.

[0045] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the thickener in the C phase is 0.5 wt% - 1.5 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the thickener in the C phase is 0.5 wt%, 1.0 wt% or 1.5 wt%.

[0046] In some embodiments, calculated based on the total mass of the cosmetic composition, the total content of the emulsifier in the C phase is 2.5 wt% - 4 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the total content of the emulsifier in the C phase is 2.5 wt%, 3 wt%, 3.3 wt%, 3.5 wt% or 4 wt%.

[0047] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the emollient in the C phase is 8 wt% - 12 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the emollient in the C phase is 8 wt%, 9 wt%, 10 wt%, 11 wt% or 12 wt%.

[0048] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the film-forming agent in the C phase is 1 wt% - 5 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the film-forming agent in the C phase is 1 wt%, 2 wt%, 2.5 wt%, 3 wt%, 4 wt% or 5 wt%.

[0049] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the skin feel regulator in the C phase is 1 wt% - 5 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the skin feel regulator in the C phase is 1 wt%, 2 wt%, 2.5 wt%, 3 wt%, 4 wt% or 5 wt%.

[0050] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the humectant in the D phase is 8 wt% - 20 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the humectant in the D phase is 8 wt%, 9 wt%, 10 wt%, 11 wt%, 12 wt%, 13 wt%, 14 wt%, 15 wt%, 16 wt%, 17 wt%, 18 wt%, 19 wt% or 20 wt%.

[0051] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the antioxidant in the D phase is 0.4 wt% - 0.6 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the antioxidant in the D phase is 0.4 wt%, 0.5 wt% or 0.6 wt%.

[0052] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the antifreeze in the D phase is 0.5 wt% - 1.2 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the antifreeze in the D phase is 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1.0 wt%, 1.1 wt% or 1.2 wt%.

[0053] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the thickener in the D phase is 0.03 wt% - 0.08 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the thickener in the D phase is 0.03 wt%, 0.04 wt%, 0.05 wt%, 0.06 wt%, 0.07 wt% or 0.08 wt%.

[0054] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of water in the D phase is 31.52 wt% - 63.008 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of water in the D phase is 31.52 wt%, 35.00 wt%, 36.00 wt%, 37.00 wt%, 37.02 wt%, 40.00 wt%, 45.00 wt%, 46.400 wt%, 50.00 wt%, 50.553 wt%, 55.00 wt%, 60.00 wt% or 63.008 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the sum of the content of water in the D phase and the content of emollient in phase A, powder dispersant in phase A, emollient in phase B, active ingredient in phase B, thickener in phase C, emulsifier in phase C, emollient in phase C, film-forming agent in phase C, skin feel regulator in phase C, humectant in phase D, antioxidant in phase D, antifreeze in phase D and thickener in phase D is 100 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the sum of the content of water in the D phase and the content of emollient in phase A, powder dispersant in phase A, colorant in phase A, emollient in phase B, active ingredient in phase B, thickener in phase C, emulsifier in phase C, emollient in phase C, film-forming agent in phase C, skin feel regulator in phase C, humectant in phase D, antioxidant in phase D, antifreeze in phase D and thickener in phase D is 100 wt%.

[0055] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 4 wt% - 7 wt%, the content of the powder dispersant in the A phase is 0.5 wt% - 1.5 wt%, the total content of the active ingredients is 0.010 wt% - 1.100 wt%, the content of the emollient in the B phase is 2 wt% - 3 wt%, the content of the thickener in the C phase is 0.5 wt% - 1.5 wt%; the total content of the emulsifier in the C phase is 2.5 wt% - 4 wt%, the content of the emollient in the C phase is 8 wt% - 12 wt%, the content of the film-forming agent in the C phase is 1 wt% - 5 wt%, the content of the skin feel regulator in the C phase is 1 wt% - 5 wt%, the content of the humectant in the D phase is 8 wt% - 20 wt%, the content of the antioxidant in the D phase is 0.4 wt% - 0.6 wt%, the content of the antifreeze agent in the D phase is 0.5 wt% - 1.2 wt%, the content of the thickener in the D phase is 0.03 wt% - 0.08 wt%, and the balance is water.

[0056] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 4 wt% - 7 wt%, the content of the powder dispersant in the A phase is 0.5 wt% - 1.5 wt%, the total content of the active ingredients is 0.017 wt% - 1.100 wt%, the content of the emollient in the B phase is 2 wt% - 3 wt%, the content of the thickener in the C phase is 0.5 wt% - 1.5 wt%; the total content of the emulsifier in the C phase is 2.5 wt% - 4 wt%, the content of the emollient in the C phase is 8 wt% - 12 wt%, the content of the film-forming agent in the C phase is 1 wt% - 5 wt%, the content of the skin feel regulator in the C phase is 1 wt% - 5 wt%, the content of the humectant in the D phase is 8 wt% - 20 wt%, the content of the antioxidant in the D phase is 0.4 wt% - 0.6 wt%, the content of the antifreeze agent in the D phase is 0.5 wt% - 1.2 wt%, the content of the thickener in the D phase is 0.03 wt% - 0.08 wt%, and the balance is water.

[0057] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 4 wt%, the content of the powder dispersant in the A phase is 0.5 wt%, the total content of the active ingredient is 0.017 wt%, the content of the emollient in the B phase is 2 wt%, and the content of the thickener in the C phase is 0.5 wt%; the total content of the emulsifier in the C phase is 2.5 wt%, the content of the emollient in the C phase is 8 wt%, the content of the film-forming agent in the C phase is 1 wt%, the content of the skin feel regulator in the C phase is 1 wt%, the content of the humectant in the D phase is 20 wt%, the content of the antioxidant in the D phase is 0.4 wt%, the content of the antifreeze agent in the D phase is 0.5 wt%, the content of the thickener in the D phase is 0.03 wt%, and the balance is water.

[0058] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 5 wt%, the content of the powder dispersant in the A phase is 0.9 wt%, the total content of the active ingredient is 0.550 wt%, the content of the emollient in the B phase is 2.5 wt%, and the content of the thickener in the C phase is 1.0 wt%; the total content of the emulsifier in the C phase is 3.3 wt%, the content of the emollient in the C phase is 9 wt%, the content of the film-forming agent in the C phase is 2.5 wt%, the content of the skin feel regulator in the C phase is 2.5 wt%, the content of the humectant in the D phase is 14 wt%, the content of the antioxidant in the D phase is 0.5 wt%, the content of the antifreeze agent in the D phase is 0.8 wt%, the content of the thickener in the D phase is 0.05 wt%, and the balance is water.

[0059] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 7 wt%, the content of the powder dispersant in the A phase is 1.5 wt%, the total content of the active ingredient is 1.100 wt%, the content of the emollient in the B phase is 3 wt%, and the content of the thickener in the C phase is 1.5 wt%; the total content of the emulsifier in the C phase is 4 wt%, the content of the emollient in the C phase is 12 wt%, the content of the film-forming agent in the C phase is 5 wt%, the content of the skin feel regulator in the C phase is 5 wt%, the content of the humectant in the D phase is 8 wt%, the content of the antioxidant in the D phase is 0.6 wt%, the content of the antifreeze agent in the D phase is 1.2 wt%, the content of the thickener in the D phase is 0.08 wt%, and the balance is water.

[0060] In some embodiments, based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 4 wt% - 7 wt%, the content of the powder dispersant in the A phase is 0.5 wt% - 1.5 wt%, the total content of the colorant in the A phase is 9 wt% - 13 wt%, the total content of the active ingredient is 0.010 wt% - 1.100 wt%, the content of the emollient in the B phase is 2 wt% - 3 wt%, the content of the thickener in the C phase is 0.5 wt% - 1.5 wt%; the total content of the emulsifier in the C phase is 2.5 wt% - 4 wt%, the content of the emollient in the C phase is 8 wt% - 12 wt%, the content of the film-forming agent in the C phase is 1 wt% - 5 wt%, the content of the skin feel regulator in the C phase is 1 wt% - 5 wt%, the content of the humectant in the D phase is 8 wt% - 20 wt%, the content of the antioxidant in the D phase is 0.4 wt% - 0.6 wt%, the content of the antifreeze agent in the D phase is 0.5 wt% - 1.2 wt%, the content of the thickener in the D phase is 0.03 wt% - 0.08 wt%, and the balance is water.

[0061] In some embodiments, based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 4 wt% - 7 wt%, the content of the powder dispersant in the A phase is 0.5 wt% - 1.5 wt%, the total content of the colorant in the A phase is 9 wt% - 13 wt%, the total content of the active ingredient is 0.017 wt% - 1.100 wt%, the content of the emollient in the B phase is 2 wt% - 3 wt%, the content of the thickener in the C phase is 0.5 wt% - 1.5 wt%; the total content of the emulsifier in the C phase is 2.5 wt% - 4 wt%, the content of the emollient in the C phase is 8 wt% - 12 wt%, the content of the film-forming agent in the C phase is 1 wt% - 5 wt%, the content of the skin feel regulator in the C phase is 1 wt% - 5 wt%, the content of the humectant in the D phase is 8 wt% - 20 wt%, the content of the antioxidant in the D phase is 0.4 wt% - 0.6 wt%, the content of the antifreeze agent in the D phase is 0.5 wt% - 1.2 wt%, the content of the thickener in the D phase is 0.03 wt% - 0.08 wt%, and the balance is water.

[0062] In some embodiments, based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 4 wt%, the content of the powder dispersant in the A phase is 0.5 wt%, the total content of the colorant in the A phase is 9 wt%, the total content of the active ingredient is 0.017 wt%, the content of the emollient in the B phase is 2 wt%, and the content of the thickener in the C phase is 0.5 wt%; the total content of the emulsifier in the C phase is 2.5 wt%, the content of the emollient in the C phase is 8 wt%, the content of the film-forming agent in the C phase is 1 wt%, the content of the skin feel regulator in the C phase is 1 wt%, the content of the humectant in the D phase is 20 wt%, the content of the antioxidant in the D phase is 0.4 wt%, the content of the antifreeze agent in the D phase is 0.5 wt%, the content of the thickener in the D phase is 0.03 wt%, and the balance is water.

[0063] In some embodiments, based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 5 wt%, the content of the powder dispersant in the A phase is 0.9 wt%, the total content of the colorant in the A phase is 11 wt%, the total content of the active ingredient is 0.550 wt%, the content of the emollient in the B phase is 2.5 wt%, and the content of the thickener in the C phase is 1.0 wt%; the total content of the emulsifier in the C phase is 3.3 wt%, the content of the emollient in the C phase is 9 wt%, the content of the film-forming agent in the C phase is 2.5 wt%, the content of the skin feel regulator in the C phase is 2.5 wt%, the content of the humectant in the D phase is 14 wt%, the content of the antioxidant in the D phase is 0.5 wt%, the content of the antifreeze agent in the D phase is 0.8 wt%, the content of the thickener in the D phase is 0.05 wt%, and the balance is water.

[0064] In some embodiments, based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 7 wt%, the content of the powder dispersant in the A phase is 1.5 wt%, the total content of the colorant in the A phase is 13 wt%, the total content of the active ingredient is 1.100 wt%, the content of the emollient in the B phase is 3 wt%, and the content of the thickener in the C phase is 1.5 wt%; the total content of the emulsifier in the C phase is 4 wt%, the content of the emollient in the C phase is 12 wt%, the content of the film-forming agent in the C phase is 5 wt%, the content of the skin feel regulator in the C phase is 5 wt%, the content of the humectant in the D phase is 8 wt%, the content of the antioxidant in the D phase is 0.6 wt%, the content of the antifreeze agent in the D phase is 1.2 wt%, the content of the thickener in the D phase is 0.08 wt%, and the balance is water.

[0065] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone is 0.5 wt% - 1.5 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone is 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.1 wt%, 1.2 wt%, 1.3 wt%, 1.4 wt% or 1.5 wt%.

[0066] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of polydimethylsiloxane is 4 wt% - 7 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of polydimethylsiloxane is 4 wt%, 4.5 wt%, 5.0 wt%, 5.5 wt%, 6 wt%, 6.5 wt% or 7 wt%.

[0067] In some embodiments, the colorant in the A phase is at least one of CI 77891, CI 77492, CI 77491, CI 77499, and calculated based on the total mass of the cosmetic composition, the total content of the colorant in the A phase is 9 wt% - 13 wt%. In some embodiments, the colorant in the A phase is at least one of CI 77891, CI 77492, CI 77491, CI 77499, and calculated based on the total mass of the cosmetic composition, the total content of the colorant in the A phase is 9 wt%, 10 wt%, 11 wt%, 12 wt% or 13 wt%.

[0068] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of Calophyllum inophyllum oil is 0.005 wt% - 0.500 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of Calophyllum inophyllum oil is 0.005 wt%, 0.010 wt%, 0.020 wt%, 0.050 wt%, 0.100 wt%, 0.150 wt%, 0.200 wt%, 0.250 wt%, 0.300 wt%, 0.350 wt%, 0.40 wt%, 0.450 wt% or 0.500 wt%.

[0069] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of ceramide NP is 0.010 wt% - 0.500 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of ceramide NP is 0.010 wt%, 0.050 wt%, 0.100 wt%, 0.150 wt%, 0.200 wt%, 0.250 wt%, 0.300 wt%, 0.350 wt%, 0.40 wt%, 0.450 wt% or 0.500 wt%.

[0070] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of heparin sodium is 0.001 wt% - 0.050 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of heparin sodium is 0.001 wt%, 0.005 wt%, 0.010 wt%, 0.015 wt%, 0.020 wt%, 0.025 wt%, 0.030 wt%, 0.035 wt%, 0.040 wt%, 0.045 wt% or 0.050 wt%.

[0071] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of Glycyrrhiza inflata Bat. extract is 0.001 wt% - 0.050 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of Glycyrrhiza inflata Bat. extract is 0.001 wt%, 0.005 wt%, 0.010 wt%, 0.015 wt%, 0.020 wt%, 0.025 wt%, 0.030 wt%, 0.035 wt%, 0.040 wt%, 0.045 wt% or 0.050 wt%.

[0072] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of licorinchalcone A is 0.00021 wt% - 0.0105 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of licorinchalcone A is 0.00021 wt%, 0.00050 wt%, 0.00100 wt%, 0.00200 wt%, 0.00300 wt%, 0.00400 wt%, 0.00500 wt%, 0.00525 wt%, 0.00600 wt%, 0.00700 wt%, 0.00800 wt%, 0.00900 wt%, 0.01000 wt%, 0.0105 wt%.

[0073] In some embodiments, calculated based on the total mass of the cosmetic composition, the content of triglyceride (ethylhexyl ester) is 2 wt% - 3 wt%. In some embodiments, calculated based on the total mass of the cosmetic composition, the content of triglyceride (ethylhexyl ester) is 2 wt%, 2.5 wt% or 3 wt%.

[0074] In some embodiments, the thickener in the C phase is lithium magnesium stearate montmorillonite. Calculated based on the total mass of the cosmetic composition, the content of lithium magnesium stearate montmorillonite is 0.5 wt% - 1.5 wt%. In some embodiments, the thickener in the C phase is lithium magnesium stearate montmorillonite. Calculated based on the total mass of the cosmetic composition, the content of lithium magnesium stearate montmorillonite is 0.5 wt%, 1.0 wt% or 1.5 wt%.

[0075] In some embodiments, the skin feel modifier in the C phase is silica. Calculated based on the total mass of the cosmetic composition, the content of silica is 1 wt% - 5 wt%. In some embodiments, the skin feel modifier in the C phase is silica. Calculated based on the total mass of the cosmetic composition, the content of silica is 1 wt%, 2 wt%, 3 wt%, 4 wt% or 5 wt%.

[0076] In some embodiments, the emollient in the C phase is diisostearyl malate. Calculated based on the total mass of the cosmetic composition, the content of diisostearyl malate is 7 wt% - 12 wt%. In some embodiments, the emollient in the C phase is diisostearyl malate. Calculated based on the total mass of the cosmetic composition, the content of diisostearyl malate is 7 wt%, 8 wt%, 9 wt%, 10 wt%, 11 wt% or 12 wt%.

[0077] In some embodiments, the film-forming agent in the C phase is trimethylsilyloxy silicate. Calculated based on the total mass of the cosmetic composition, the content of trimethylsilyloxy silicate is 1 wt% - 5 wt%. In some embodiments, the film-forming agent in the C phase is trimethylsilyloxy silicate. Calculated based on the total mass of the cosmetic composition, the content of trimethylsilyloxy silicate is 1 wt%, 2 wt%, 3 wt%, 4 wt% or 5 wt%.

[0078] In some embodiments, the emulsifier in the C phase includes cetyl PEG / PPG-10 / 1 dimethicone. Calculated based on the total mass of the cosmetic composition, the content of cetyl PEG / PPG-10 / 1 dimethicone is 1 wt% - 1.5 wt%.

[0079] In some embodiments, the emulsifier in the C phase includes lauryl PEG-9 polydimethylsiloxyethyl dimethicone. Calculated based on the total mass of the cosmetic composition, the content of lauryl PEG-9 polydimethylsiloxyethyl dimethicone is 1.5 wt% - 2.5 wt%. In some embodiments, the emulsifier in the C phase includes lauryl PEG-9 polydimethylsiloxyethyl dimethicone. Calculated based on the total mass of the cosmetic composition, the content of lauryl PEG-9 polydimethylsiloxyethyl dimethicone is 1.5 wt%, 2.0 wt% or 2.5 wt%.

[0080] In some embodiments, the emulsifier in the C phase includes cetyl PEG / PPG-10 / 1 dimethicone and lauryl PEG-9 polydimethylsiloxyethyl dimethicone. Calculated based on the total mass of the cosmetic composition, the content of cetyl PEG / PPG-10 / 1 dimethicone is 1 wt% - 1.5 wt%; the content of lauryl PEG-9 polydimethylsiloxyethyl dimethicone is 1.5 wt% - 2.5 wt% (such as 1.5 wt%, 2.0 wt% or 2.5 wt%).

[0081] In some embodiments, the humectant in the D phase includes glycerol; calculated based on the total mass of the cosmetic composition, the content of glycerol is 4 wt% - 6 wt%. In some embodiments, the humectant in the D phase includes glycerol; calculated based on the total mass of the cosmetic composition, the content of glycerol is 4 wt%, 5 wt% or 6 wt%.

[0082] In some embodiments, the humectant in the D phase includes 1,3-butanediol; calculated based on the total mass of the cosmetic composition, the content of 1,3-butanediol is 1.4 wt% - 15.6 wt%. In some embodiments, the humectant in the D phase includes 1,3-butanediol; calculated based on the total mass of the cosmetic composition, the content of 1,3-butanediol is 1.4 wt%, 1.5 wt%, 2.0 wt%, 2.5 wt%, 3.0 wt%, 4.0 wt%, 5.0 wt%, 6.0 wt%, 7.0 wt%, 8.0 wt%, 9.0 wt%, 10.0 wt%, 11.0 wt%, 12.0 wt%, 13.0 wt%, 14.0 wt%, 15.0 wt% or 15.6 wt%.

[0083] In some embodiments, the humectant in the D phase includes 1,2 - hexanediol; calculated based on the total mass of the cosmetic composition, the content of 1,2 - hexanediol is 0.4 wt% - 0.6 wt%. In some embodiments, the humectant in the D phase includes 1,2 - hexanediol; calculated based on the total mass of the cosmetic composition, the content of 1,2 - hexanediol is 0.4 wt%, 0.5 wt% or 0.6 wt%.

[0084] In some embodiments, the humectants in the D phase include glycerol, 1,3 - butanediol and 1,2 - hexanediol; calculated based on the total mass of the cosmetic composition, the content of glycerol is 4 wt% - 6 wt% (such as 4 wt%, 5 wt% or 6 wt%), the content of 1,3 - butanediol is 1.4 wt% - 15.6 wt% (such as 1.4 wt%, 1.5 wt%, 2.0 wt%, 2.5 wt%, 3.0 wt%, 4.0 wt%, 5.0 wt%, 6.0 wt%, 7.0 wt%, 8.0 wt%, 9.0 wt%, 10.0 wt%, 11.0 wt%, 12.0 wt%, 13.0 wt%, 14.0 wt%, 15.0 wt% or 15.6 wt%), and the content of 1,2 - hexanediol is 0.4 wt% - 0.6 wt% (such as 0.4 wt%, 0.5 wt% or 0.6 wt%).

[0085] In some embodiments, the antioxidant in the D phase is p - hydroxyacetophenone; calculated based on the total mass of the cosmetic composition, the content of p - hydroxyacetophenone is 0.4 wt% - 0.6 wt%. In some embodiments, the antioxidant in the D phase is p - hydroxyacetophenone; calculated based on the total mass of the cosmetic composition, the content of p - hydroxyacetophenone is 0.4 wt%, 0.5 wt% or 0.6 wt%.

[0086] In some embodiments, the antifreeze in the D phase is sodium chloride; calculated based on the total mass of the cosmetic composition, the content of sodium chloride is 0.5 wt% - 1.2 wt%. In some embodiments, the antifreeze in the D phase is sodium chloride; calculated based on the total mass of the cosmetic composition, the content of sodium chloride is 0.5 wt%, 1.0 wt% or 1.2 wt%.

[0087] In some embodiments, the thickener in the D phase is xanthan gum; calculated based on the total mass of the cosmetic composition, the content of xanthan gum is 0.03 wt% - 0.08 wt%. In some embodiments, the thickener in the D phase is xanthan gum; calculated based on the total mass of the cosmetic composition, the content of xanthan gum is 0.03 wt%, 0.04 wt%, 0.05 wt%, 0.06 wt%, 0.07 wt% or 0.08 wt%.

[0088] In some embodiments, the active ingredients include Calophyllum inophyllum oil, ceramide NP, heparin sodium, and at least one selected from Glycyrrhiza inflata extract and licochalcone A; the powder dispersant in the A phase is lauryl polyglyceryl-3 polydimethylsiloxyethyl polydimethylsiloxane; the emollient in the A phase is polydimethylsiloxane; the A phase further includes a colorant; the colorant includes titanium dioxide and / or iron oxide; The emollient in the B phase is triethylhexanoin; The thickener in the C phase is lithium magnesium stearate montmorillonite; the skin feel regulator in the C phase is at least one of silica and silica powder; the emollient in the C phase is diisostearyl malate; the film-forming agent in the C phase is trimethylsiloxysilicate; the emulsifier in the C phase is cetyl PEG / PPG-10 / 1 polydimethylsiloxane and lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane; The humectants in the D phase are glycerol, 1,3-butanediol, and 1,2-hexanediol; the thickener in the D phase is xanthan gum; the antioxidant is hydroxyacetophenone; the antifreeze agent is sodium chloride; Calculated based on the total mass of the cosmetic composition, the content of the emollient in the A phase is 4 wt% - 7 wt%, the content of the powder dispersant in the A phase is 0.5 wt% - 1.5 wt%, the total content of the colorant in the A phase is 9 wt% - 13 wt%, the content of Calophyllum inophyllum oil is 0.005 wt% - 0.500 wt%, the content of ceramide NP is 0.010 wt% - 0.500 wt%, the content of heparin sodium is 0.001 wt% - 0.050 wt%, the content of Glycyrrhiza inflata extract is 0.001 wt% - 0.050 wt% or the content of licochalcone A is 0.00021 wt% - 0.0105 wt%, the content of the emollient in the B phase is 2 wt% - 3 wt%, the content of the thickener in the C phase is 0.5 wt% - 1.5 wt%; the content of cetyl PEG / PPG-10 / 1 dimethicone in the C phase is 1.0 wt% - 1.5 wt%, the content of lauryl PEG-9 dimethicone copolyol in the C phase is 1.5 wt% - 2.5 wt%, the content of the emollient in the C phase is 8 wt% - 12 wt%, the content of the film-forming agent in the C phase is 1 wt% - 5 wt%, the content of the skin feel regulator in the C phase is 1 wt% - 5 wt%, the content of glycerol in the D phase is 4.0 wt% - 6.0 wt%, the content of 1,3-butanediol in the D phase is 1.4 wt% - 15.6 wt%, the content of 1,2-hexanediol in the D phase is 0.4 wt% - 0.6 wt%, the content of the antioxidant in the D phase is 0.4 wt% - 0.6 wt%, the content of the antifreeze in the D phase is 0.5 wt% - 1.2 wt%, the content of the thickener in the D phase is 0.03 wt% - 0.08 wt%, and the balance is water.

[0089] In a second aspect, the present invention provides a method for preparing the cosmetic composition described in the first aspect.

[0090] A method for preparing the cosmetic composition described in the first aspect, which includes: Step (1): Mix the components in the A phase and grind to obtain a mixed solution of the A phase; Step (2): Mix the components in the B phase, heat and stir to dissolve to obtain a mixed solution of the B phase; Step (3): Mix the mixed solution of the A phase, the mixed solution of the B phase and the components in the C phase, and stir evenly to obtain a mixed solution of ABC; Step (4): Mix the components in the D phase, heat and stir to dissolve to obtain a mixed solution of the D phase; Step (5): Heat the D-phase mixture and the ABC mixture to 80°C - 85°C (such as 80°C, 81°C, 82°C, 83°C, 84°C or 85°C), then add the D-phase mixture to the ABC mixture, stir, homogenize and emulsify, and then cool down to obtain the cosmetic composition.

[0091] In some embodiments, after the components in phase B in step (2) are mixed, they are stirred and dissolved at 80°C - 90°C (such as 80°C, 81°C, 82°C, 83°C, 84°C, 85°C, 86°C, 87°C, 88°C, 89°C or 90°C) to obtain the B-phase mixture.

[0092] In some embodiments, the stirring in step (3) is carried out at 80°C - 85°C (such as 80°C, 81°C, 82°C, 83°C, 84°C or 85°C).

[0093] In some embodiments, after the components in phase D in step (4) are mixed, they are stirred and dissolved at 80°C - 85°C (such as 80°C, 81°C, 82°C, 83°C, 84°C or 85°C) to obtain the D-phase mixture.

[0094] In some embodiments, the cooling in step (5) is to cool down to 30°C - 40°C (such as 30°C, 31°C, 32°C, 33°C, 34°C, 35°C, 36°C, 37°C, 38°C, 39°C or 40°C).

[0095] In some embodiments, the homogenization speed of the homogenization and emulsification is 4500 rpm - 6000 rpm. In some embodiments, the homogenization speed of the homogenization and emulsification is 4500 rpm, 5000 rpm, 5500 rpm or 6000 rpm.

[0096] In some embodiments, the homogenization time of the homogenization and emulsification is 5 minutes - 10 minutes. In some embodiments, the homogenization time of the homogenization and emulsification is 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes or 10 minutes.

[0097] In a third aspect, the present invention provides a use of the foregoing cosmetic composition or the cosmetic composition prepared by the preparation method.

[0098] A use of the cosmetic composition according to the first aspect or the cosmetic composition prepared by the preparation method according to the second aspect in the preparation of cosmetics.

[0099] In some embodiments, the cosmetics are used for moisturizing, soothing and / or removing acne.

[0100] Beneficial effects Compared with the prior art, at least one of the following beneficial effects is achieved in a certain embodiment of the present invention: (1) The cosmetic composition provided by the present invention has good stability, is mild and non-irritating, has a good soothing effect, and has good moisturizing and acne-removing effects, and has excellent technical effects.

[0101] (2) Compared with using other thickeners, using the lithium magnesium silicate quaternium-18 provided by the present invention as a thickener is more conducive to improving the high-temperature and low-temperature stability of the cosmetic composition of the present invention.

[0102] (3) Compared with using other emulsifiers, using cetyl PEG / PPG-10 / 1 dimethicone and lauryl PEG-9 dimethicone copolyol as emulsifiers is more conducive to improving the high-temperature and low-temperature stability of the cosmetic composition of the present invention.

[0103] (4) The cosmetic composition of the present invention simultaneously combined with Calophyllum inophyllum oil, ceramide NP, heparin sodium and Glycyrrhiza inflata extract as active ingredients has a more significant superposition effect of the moisturizing, soothing and acne-removing effects of these 4 single active ingredients, and has an unexpected synergistic technical effect.

[0104] (5) Compared with adding only 1, 2 or 3 kinds of efficacy substances in the cosmetic composition of the present invention, using the cosmetic composition provided by the present invention is more conducive to improving the moisturizing, soothing and acne-removing effects of the cosmetics of the present invention, and has an unexpected synergistic technical effect.

[0105] Term Explanation In the description of the present invention, "a plurality of" means two or more, unless otherwise specifically defined.

[0106] The term "room temperature" refers to the ambient temperature, which means a temperature of about 10°C to about 30°C, or about 20°C to 30°C, or about 25°C.

[0107] The term "wt%" means mass percentage.

[0108] In the description of this specification, the description with reference to the terms "an embodiment", "some embodiments", "examples", "specific examples", or "some examples", etc. means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0109] In the following content, all numbers disclosed herein are approximate values whether the words "about" or "approximate" are used or not. The numerical value of each number may vary by 1%, 2%, 5%, 7%, 8%, 10%, 15% or 20%, etc. Whenever a number with a value of N is disclosed, any number with a value of N+ / -1%, N+ / -2%, N+ / -3%, N+ / -5%, N+ / -7%, N+ / -8%, N+ / -10%, N+ / -15% or N+ / -20% will be explicitly disclosed, where "+ / -" means plus or minus.

[0110] Licochalcone A: Molecular formula C 21 H 22 O 4 , CAS No.: 58749-22-7.

[0111] Ceramide NP: The structural formula is: Sodium heparinate: The Chinese INCI name is glucosaminoglucan; CAS No. is 94945-04-7. Detailed implementation manners

[0112] To enable those skilled in the art to better understand the technical solutions of the present invention, some non-limiting embodiments are further disclosed below to further elaborate on the present invention in detail.

[0113] All the reagents used in the present invention can be purchased from the market or can be prepared by the methods described in the present invention.

[0114] I. The sources of some reagents used in the embodiments or comparative examples of the present invention are as follows: Extract of Glycyrrhiza inflata Bat.: Purchased from Chenfeng Natural Herbs (Beijing) Technology Co., Ltd., trade name: Licochalcone A 21%; product code: SHGC1001.

[0115] Calophyllum inophyllum L. oil: Purchased from CordenPharma (Guangzhou) Trading Co., Ltd., trade name: Tahitian Tamanu Oil (English name: TAHIDERM TAMANU OIL); code: 888-TAHTAM1; INCI name: Calophyllum inophyllum L. seed oil, tocopherol (vitamin E); CAS#: 241148-25-4 / 59-02-9.

[0116] Sodium heparinate: Purchased from Shanghai Huiwen Biotechnology Co., Ltd.

[0117] II. Equipment and instruments Homogenizing equipment: IKA T25 easy clean.

[0118] Examples 1 - 3: Preparation of Cosmetic Compositions Formulation: See Table 1.

[0119] Table 1: Formulation of Cosmetic Compositions

[0120] Preparation Method: Step (1): Mix the components in Phase A, grind them to obtain a mixed solution of Phase A; Step (2): Mix the components in Phase B, heat them to 85°C (it can be 80 - 90°C), stir and dissolve to obtain a mixed solution of Phase B; Step (3): Mix the components in the mixed solution of Phase A, the mixed solution of Phase B and Phase C, stir evenly, raise the temperature to 80°C (it can be 80°C - 85°C) to obtain a mixed solution of ABC; Step (4): Mix the components in Phase D, heat them to 80°C (it can be 80°C - 85°C), stir and dissolve to obtain a mixed solution of Phase D; Step (5): Add the mixed solution of Phase D at 80°C (it can be 80°C - 85°C) to the mixed solution of ABC at 80°C (it can be 80°C - 85°C), stir, homogenize and emulsify (the homogenization speed is 4500 rpm (it can be 4500 rpm - 6000 rpm), the homogenization time is 5 minutes (it can be 5 - 10 minutes)), and then cool down to 30°C (it can be 30°C - 40°C) to obtain the cosmetic composition.

[0121] Comparative Examples 1 - 4: Investigation of Single Active Ingredients Based on the formulation of Example 2, investigate the formulation of single active ingredients.

[0122] Comparative Example 1: The active ingredient is tamanu oil, and it does not contain other active ingredients (ceramide NP, heparin sodium, and extract of Glycyrrhiza inflata Bat.), and appropriately increase the content of the solvent in Phase D. The increased content of the solvent in Phase D corresponds to the sum of the original contents of the other active ingredients (ceramide NP, heparin sodium, and extract of Glycyrrhiza inflata Bat.) that are not contained. The remaining components, component contents, and preparation method are the same as those in Example 2.

[0123] Comparative Example 2: The active ingredient is ceramide NP, the content of ceramide NP is the same as that in Example 2, and it does not contain other active ingredients (tamanu oil, heparin sodium, and extract of Glycyrrhiza inflata Bat.), and appropriately increase the content of the solvent in Phase D. The increased content of the solvent in Phase D corresponds to the sum of the original contents of the other active ingredients (tamanu oil, heparin sodium, and extract of Glycyrrhiza inflata Bat.) that are not contained. The remaining components, component contents, and preparation method are the same as those in Example 2.

[0124] Comparative Example 3: The active ingredient is heparin sodium. The content of heparin sodium is the same as that in Example 2, and it does not contain other active ingredients (Calophyllum inophyllum oil, ceramide NP, and Glycyrrhiza inflata extract). The content of the solvent in Phase D is adaptively increased, and the increased content of the solvent in Phase D corresponds to the sum of the original contents of the other active ingredients not contained (Calophyllum inophyllum oil, ceramide NP, and Glycyrrhiza inflata extract). The other components, component contents, and preparation method are the same as those in Example 2.

[0125] Comparative Example 4: The active ingredient is Glycyrrhiza inflata extract. The content of Glycyrrhiza inflata extract is the same as that in Example 2, and it does not contain other active ingredients (Calophyllum inophyllum oil, ceramide NP, and heparin sodium). The content of the solvent in Phase D is adaptively increased, and the increased content of the solvent in Phase D corresponds to the sum of the original contents of the other active ingredients not contained (Calophyllum inophyllum oil, ceramide NP, and heparin sodium). The other components, component contents, and preparation method are the same as those in Example 2.

[0126] Comparative Examples 5 - 10: Investigation of dual active ingredients Based on the formulation of Example 2, the dual active ingredient formulations were investigated.

[0127] Comparative Example 5: The active ingredients are Calophyllum inophyllum oil and ceramide NP. The contents of Calophyllum inophyllum oil and ceramide NP are the same as those in Example 2, and it does not contain other active ingredients (heparin sodium, Glycyrrhiza inflata extract). The content of the solvent in Phase D is adaptively increased, and the increased content of the solvent in Phase D corresponds to the sum of the original contents of the other active ingredients not contained (heparin sodium, Glycyrrhiza inflata extract). The other components, component contents, and preparation method are the same as those in Example 2.

[0128] Comparative Example 6: The active ingredients are Calophyllum inophyllum oil and heparin sodium. The contents of Calophyllum inophyllum oil and heparin sodium are the same as those in Example 2, and it does not contain other active ingredients (ceramide NP, Glycyrrhiza inflata extract). The content of the solvent in Phase D is adaptively increased, and the increased content of the solvent in Phase D corresponds to the sum of the original contents of the other active ingredients not contained (ceramide NP, Glycyrrhiza inflata extract). The other components, component contents, and preparation method are the same as those in Example 2.

[0129] Comparative Example 7: The active ingredients are Calophyllum inophyllum oil and Glycyrrhiza inflata extract. The contents of Calophyllum inophyllum oil and Glycyrrhiza inflata extract are the same as those in Example 2, and it does not contain other active ingredients (ceramide NP, heparin sodium). The content of the solvent in Phase D is adaptively increased, and the increased content of the solvent in Phase D corresponds to the sum of the original contents of the other active ingredients not contained (ceramide NP, heparin sodium). The other components, component contents, and preparation method are the same as those in Example 2.

[0130] Comparative Example 8: The active ingredients are heparin sodium and Glycyrrhiza inflata extract. The contents of heparin sodium and Glycyrrhiza inflata extract are the same as those in Example 2, and no other active ingredients (Calophyllum inophyllum oil, ceramide NP) are contained. The content of the solvent in Phase D is adaptively increased, and the increased content of the solvent in Phase D corresponds to the sum of the original contents of the other active ingredients not contained (Calophyllum inophyllum oil, ceramide NP). The other components, component contents and preparation method are the same as those in Example 2.

[0131] Comparative Example 9: The active ingredients are ceramide NP and heparin sodium. The contents of ceramide NP and heparin sodium are the same as those in Example 2, and no other active ingredients (Calophyllum inophyllum oil, Glycyrrhiza inflata extract) are contained. The content of the solvent in Phase D is adaptively increased, and the increased content of the solvent in Phase D corresponds to the sum of the original contents of the other active ingredients not contained (Calophyllum inophyllum oil, Glycyrrhiza inflata extract). The other components, component contents and preparation method are the same as those in Example 2.

[0132] Comparative Example 10: The active ingredients are ceramide NP and Glycyrrhiza inflata extract. The contents of ceramide NP and Glycyrrhiza inflata extract are the same as those in Example 2, and no other active ingredients (Calophyllum inophyllum oil, heparin sodium) are contained. The content of the solvent in Phase D is adaptively increased, and the increased content of the solvent in Phase D corresponds to the sum of the original contents of the other active ingredients not contained (Calophyllum inophyllum oil, heparin sodium). The other components, component contents and preparation method are the same as those in Example 2.

[0133] Comparative Examples 11 - 14: Investigation of three active ingredients Based on the formulation of Example 2, the formulation of three active ingredients is investigated.

[0134] Comparative Example 11: Calophyllum inophyllum oil is not added, and the content of the solvent in Phase D is adaptively increased. The increased content of the solvent in Phase D corresponds to the original content of the Calophyllum inophyllum oil not added. The other components, component contents and preparation method are the same as those in Example 2.

[0135] Comparative Example 12: Ceramide NP is not added, and the content of the solvent in Phase D is adaptively increased. The increased content of the solvent in Phase D corresponds to the original content of the ceramide NP not added. The other components, component contents and preparation method are the same as those in Example 2.

[0136] Comparative Example 13: Heparin sodium is not added, and the content of the solvent in Phase D is adaptively increased. The increased content of the solvent in Phase D corresponds to the original content of the heparin sodium not added. The other components, component contents and preparation method are the same as those in Example 2.

[0137] Comparative Example 14: Glycyrrhiza inflata extract is not added, and the content of the solvent in Phase D is adaptively increased. The increased content of the solvent in Phase D corresponds to the original content of the Glycyrrhiza inflata extract not added. The other components, component contents and preparation method are the same as those in Example 2.

[0138] Comparative Examples 15 - 17: Investigation of the thickener in Phase C Based on the formulation of Example 2, the thickener in Phase C was investigated.

[0139] Comparative Example 15: Lithium dimethyldistearylammonium montmorillonite in Phase C was replaced with hydrogenated (styrene / butadiene) copolymer, and the other components, component contents, and preparation method were the same as those in Example 2.

[0140] Comparative Example 16: Lithium dimethyldistearylammonium montmorillonite in Phase C was replaced with hydrogenated castor oil, and the other components, component contents, and preparation method were the same as those in Example 2.

[0141] Comparative Example 17: Lithium dimethyldistearylammonium montmorillonite in Phase C was replaced with dextrin palmitate, and the other components, component contents, and preparation method were the same as those in Example 2.

[0142] Comparative Examples 18 - 20: Investigation of the emulsifier in Phase C Based on the formulation of Example 2, the emulsifier in Phase C was investigated.

[0143] Comparative Example 18: Cetyl PEG / PPG - 10 / 1 polydimethylsiloxane in Phase C was replaced with polyglyceryl - 3 diisostearate, and the other components, component contents, and preparation method were the same as those in Example 2.

[0144] Comparative Example 19: Cetyl PEG / PPG - 10 / 1 polydimethylsiloxane in Phase C was replaced with sorbitan oleate, and the other components, component contents, and preparation method were the same as those in Example 2.

[0145] Comparative Example 20: Lauryl PEG - 9 polydimethylsiloxyethyl polydimethylsiloxane in Phase C was replaced with lauryl PEG / PPG - 18 / 18 polymethylsiloxane, and the other components, component contents, and preparation method were the same as those in Example 2.

[0146] Test Example 1: Stability investigation The stability test was carried out with reference to T / GDCQMA 002 - 2023 "Cosmetics Stability Test Specification".

[0147] High - temperature stability test: The cosmetic compositions obtained in Examples 1 - 3 and Comparative Examples 15 - 20 above were respectively placed in sealed containers and then subjected to a 3 - month stability test under high - temperature conditions (50°C ± 2°C). The appearance state, odor, etc. of each example or comparative example at 0 day and after 3 months under high - temperature conditions (50°C ± 2°C) were detected, and the results are shown in Table 2.

[0148] Cold resistance test: The cosmetic compositions obtained in Examples 1 to 3 and Comparative Examples 15 to 20 were placed in sealed containers and placed at -20°C for 3 months. The appearance, odor, etc. of each Example or Comparative Example after 0 day and -20°C for 3 months were tested. The results are shown in Table 2.

[0149] Table 2: Stability test results

[0150] in conclusion: (1) Compared with other thickeners, the use of the disteardimethylammonium hectorite provided by the present invention as a thickener is more conducive to improving the high and low temperature stability of the cosmetic composition of the present invention.

[0151] (2) Compared with other emulsifiers, the use of cetyl PEG / PPG-10 / 1 polydimethylsiloxane and lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane provided by the present invention as emulsifiers is more conducive to improving the high and low temperature stability of the cosmetic composition of the present invention.

[0152] Test Example 2: Moisturizing, soothing and acne-removing effects The above-mentioned Examples 1 to 3 and Comparative Examples 1 to 14 were respectively taken to investigate the moisturizing, soothing and acne-removing effects.

[0153] operate: 1. Select volunteers to conduct product testing and evaluation All enrolled subjects met the following inclusion and exclusion criteria: (1.1) Subject inclusion criteria: (1.1.1) 18-65 years old, healthy women or men; (1.1.2) Facial skin has problems such as excessive oiliness, redness, and acne; (1.1.3) People with sensitive skin (passed the sensitive skin questionnaire and lactic acid stinging score ≥ 3 points); (1.1.4) Have not participated in other clinical studies in the past two months, and the test site has not received any skin treatment, cosmetic treatment, or other tests that may affect the test results; (1.1.5) Those who can understand the trial process, voluntarily participate in the trial and sign the written informed consent.

[0154] (1.2) Subject exclusion criteria: (1.2.1) Pregnant or breastfeeding women or those who are planning to get pregnant in the near future; (1.2.2) Those with a history of skin diseases such as psoriasis, eczema, atopic dermatitis, severe acne, or other chronic systemic diseases; (1.2.3) Those who have taken oral or topical anti-inflammatory drugs such as corticosteroids within the past 1 month; (1.2.4) Those with highly allergic constitutions; (1.2.5) Those who have used retinoid preparations or received aesthetic medical treatments such as chemical peeling, laser, and pulsed light on the test site within the past 3 months; (1.2.6) Those who are inevitably exposed to sunlight for a long time; (1.2.7) Those who have participated in other clinical trials within the past 2 months; (1.2.8) Those who are considered unsuitable to participate in the trial according to other clinical evaluations.

[0155] (1.3) The information of the subjects selected in this test example is shown in Table 3.

[0156] Table 3 Subject Information

[0157] 2. Test Instruments and Materials Mexameter MX18, Tewameter TM HEX, Corneometer CM825.

[0158] 3. Test Location and Environment Test Address: Internal Efficacy Evaluation Laboratory.

[0159] Test Environment: Temperature 21±1°C; Humidity 50±10%.

[0160] 4. Test Methods (4.1) The test items are shown in Table 4: Table 4 Test Items

[0161] (4.2) Basic Principles Necessary toxicological tests should be completed and a written certificate should be issued before the human testing of cosmetics. Samples that fail the toxicological tests will not be subjected to human testing. According to the Declaration of Helsinki, the selection of subjects follows the medical and ethical standards of human testing. All subjects' tests must be voluntary on the part of the subjects themselves, and an informed consent form must be signed before the test. Before the subjects sign the informed consent form, the test personnel need to inform the subjects of the purpose of this test, possible benefits, potential risks and problems, as well as relevant rights and obligations.

[0162] (4.3) Test Process (4.3.1) Product Usage Method and Frequency After cleansing the face in the morning and evening, take an appropriate amount of this product and evenly apply it to the facial skin.

[0163] (4.3.2) Test steps Subjects were recruited as required and signed written informed consent. Before enrollment, subjects were asked a series of questions about their medical history and health status according to the inclusion and exclusion criteria, and then a lactic acid sting test was performed (see 4.3.2.1 for the specific testing process) to screen subjects who met the criteria to participate in this test project.

[0164] The subjects in the group cleaned their faces with facial cleanser, rinsed with water, and dried their faces with non-chip absorbent tissues. After cleaning their faces, they entered the constant temperature and humidity chamber and waited for 30 minutes. During the stabilization period, they were forbidden to eat or drink, their foreheads were exposed, and they were relaxed and avoided touching the test area.

[0165] After the rest, the skin basal value is tested and the skin testing process is completed (see 4.3.2.2 for the specific testing process). The tested area is the acne area on the face, and the subjects are informed to use the test samples according to the sample usage instructions.

[0166] (4.3.2.1) Lactic acid sting test The lactic acid stinging test is used to assess whether the subject has sensitive skin. Take 50 μL of 10% lactic acid solution and drop it on a 1cm*1cm filter paper. Apply the filter paper to the nasolabial groove on either side of the subject, and use saline as a control on the other side. The tester asks the subject about the stinging sensation at 0.5 min, 2.5 min, and 5 min, and scores it according to the "4-point method" in the table below. Those with a cumulative stinging sensation of ≥3 points on the lactic acid side relative to the saline side can be judged as sensitive skin. The lactic acid stinging score is shown in Table 4: Table 5

[0167] (4.3.2.2) Skin testing process Skin moisture content, transepidermal water loss (TEWL) and skin hemoglobin were measured by skin detector at 0 h, 7 days and 14 days respectively. The test area was 3 cm × 3 cm, and the data were recorded and analyzed statistically.

[0168] Visible acne is carefully examined and counted on a specific skin area (the face in this case) and recorded for statistical analysis.

[0169] (4.4) Data analysis Statistical analysis software is used for data statistical analysis. Measurement data are expressed as mean ± standard deviation, and normal distribution tests are conducted. If they meet the requirements of normal distribution, paired t-tests are used for comparison before and after; otherwise, the Wilcoxon signed-rank test for two related samples is used. For ordinal data, the Wilcoxon signed-rank test for two related samples is used for comparison before and after. For comparison between the test sample and the control group, independent sample t-tests or the Wilcoxon rank-sum test are used. All the above statistical analyses are two-tailed tests, and the significance level is α = 0.05.

[0170] (4.5)Basis for judging test conclusions (4.5.1)Claimed acne treatment efficacy: Using self-control before and after, observe the number of skin acne and the transepidermal water loss rate. If at any follow-up time point after using the sample, the test values of 3 or more parameters are better than the baseline values before use, and the results show significant differences (P < 0.05), then it is considered that the test sample has acne treatment efficacy.

[0171] ① Number of acne: At each follow-up point, carefully examine and count the visible acne on a specific skin area (the face is selected for this test) and record the statistical analysis. The smaller the measured value, the fewer the number of acne.

[0172] ② Measurement of transepidermal water loss rate of the skin: At each follow-up point, use the Tewameter TM HEX instrument to collect and analyze the transepidermal water loss rate of the skin. The smaller the measured value, the better the skin barrier.

[0173] (4.5.2)Claimed soothing efficacy: Using self-control before and after, observe the transepidermal water loss rate of the skin, skin heme. The smaller the three measured values, the smaller the skin erythema area, the better the skin barrier, and the weaker the flushing degree. If at any follow-up time point after using the sample, the test values of two of them are better than the baseline values before use, and the results show significant differences (P < 0.05), then it is considered that the test sample has soothing efficacy.

[0174] ③ Measurement of skin heme: At each follow-up point, use the Mexameter MX18 instrument to collect and analyze the skin heme value. The smaller the measured value, the weaker the flushing degree.

[0175] (4.5.3)Claimed moisturizing efficacy: Using self-control before and after, observe the skin TEWL and the water content of the stratum corneum, indicating less transepidermal water loss of the skin and increased water content of the stratum corneum respectively. If at any follow-up time point after using the sample, the test values of both are better than the baseline values before use, and the results show significant differences (P < 0.05), then it is considered that the test sample has moisturizing effect.

[0176] ④ Skin stratum corneum water content: At each visit point, the Comeometer CM825 instrument was used to collect and analyze the skin stratum corneum water content. The higher the measured value, the more moisturized the skin.

[0177] The actual use effect of the product is shown in Table 6.

[0178] Table 6: Skin efficacy test results

[0179] Note: The improvement rate of stratum corneum water content refers to the percentage increase compared to Day 0, that is: Improvement rate of stratum corneum water content = [(Water content of stratum corneum after use - Water content of stratum corneum on Day 0) ÷ Water content of stratum corneum on Day 0] × 100%; The improvement rates of skin heme, TEWL, and acne count are the percentage decreases compared to Day 0, that is: Improvement rate of skin heme = [(Skin heme value on Day 0 - Skin heme value after use) ÷ Skin heme value on Day 0] × 100%; Improvement rate of TEWL = [(TEWL value on Day 0 - TEWL value after use) ÷ TEWL value on Day 0] × 100%; Improvement rate of acne count = [(Acne count on Day 0 - Acne count after use) ÷ Acne count on Day 0] × 100%.

[0180] Results: (1) The cosmetic composition of the present invention simultaneously combines Calophyllum inophyllum oil, ceramide NP, heparinoid sodium, and Glycyrrhiza inflata extract as active ingredients, and has a more significant superposition effect of moisturizing, soothing, and acne-reducing effects than the simple addition of these 4 single active ingredients, and has an unexpected synergistic technical effect.

[0181] (2) Compared with adding only 1, 2, or 3 of the efficacy substances in the cosmetic composition of the present invention, using the cosmetic composition provided by the present invention is more conducive to improving the moisturizing, soothing, and acne-reducing effects of the cosmetics of the present invention, and has an unexpected synergistic technical effect.

[0182] The method of the present invention has been described by way of preferred embodiments. It is obvious that relevant personnel can make changes or appropriate alterations and combinations to the methods and applications described herein within the content, spirit and scope of the present invention to implement and apply the technology of the present invention. Those skilled in the art can draw on the content of this article and appropriately improve the process parameters to achieve it. It should be particularly noted that all such similar substitutions and alterations are obvious to those skilled in the art, and they are all considered to be included in the present invention.

Claims

1. A cosmetic composition, characterized in that include: Phase A, Phase B, Phase C and Phase D; The phase A includes an emollient and a powder dispersant; The B phase includes emollients and active ingredients; The phase C includes a thickener, an emulsifier, an emollient, a film former and a skin feel regulator; The D phase includes water, humectants, antioxidants, antifreeze agents and thickeners; The active ingredient comprises at least one of tamanu oil, ceramide NP, heparan sodium, Glycyrrhiza inflata extract and licorice chalcone A.

2. The cosmetic composition according to claim 1, wherein the emollient in phase A comprises polydimethylsiloxane; and / or The powder dispersant in phase A includes at least one of lauryl polyglyceryl-3 polydimethylsiloxyethyl polydimethylsiloxane and polyhydroxystearic acid, preferably lauryl polyglyceryl-3 polydimethylsiloxyethyl polydimethylsiloxane; and / or The emollient in phase B includes at least one of triethylhexyl glyceryl and diisostearyl malate; and / or The thickener in phase C includes at least one of disteardimethylammonium hectorite and quaternary ammonium salt-18 bentonite, preferably disteardimethylammonium hectorite; and / or The emulsifier in phase C includes at least one of cetyl PEG / PPG-10 / 1 dimethicone and lauryl PEG-9 polydimethylsiloxyethyl dimethicone; and / or The film former of phase C comprises trimethylsiloxysilicate; and / or The skin feel regulator in phase C comprises at least one of silica and silica powder; and / or The moisturizer of phase D includes at least one of glycerin, 1,3-butylene glycol, and 1,2-hexanediol; and / or The thickener in phase D comprises xanthan gum; and / or The antioxidant comprises at least one of p-hydroxyacetophenone and raspberry ketone; and / or The antifreeze agent includes at least one of sodium chloride and magnesium sulfate.

3. The cosmetic composition according to claim 2, wherein the active ingredients include tamanu oil, ceramide NP, sodium heparin and at least one selected from Glycyrrhiza inflata extract and licorice chalcone A; and / or The powder dispersant in phase A is lauryl polyglyceryl-3 polydimethylsiloxyethyl polydimethylsiloxane; and / or The emollient in phase A is polydimethylsiloxane; and / or The emollient in phase B is triethylhexyl glycerol; and / or The emulsifier in phase C is cetyl PEG / PPG-10 / 1 dimethicone and lauryl PEG-9 polydimethylsiloxyethyl dimethicone; and / or The film former of phase C is trimethylsiloxysilicate; and / or The skin feel regulator in phase C is at least one of silica and silica powder; and / or The humectant of phase D is glycerin, 1,3-butylene glycol and 1,2-hexanediol; and / or The thickener in phase D is xanthan gum; and / or The antioxidant is p-hydroxyacetophenone; and / or The antifreeze agent is sodium chloride.

4. The cosmetic composition according to any one of claims 1 to 3, wherein the phase A further comprises a colorant; and / or The colorant comprises titanium dioxide and / or iron oxide; and / or The titanium dioxide comprises CI 77891; and / or The iron oxide comprises at least one of CI 77492, CI 77491, and CI 77499; and / or Calculated based on the total mass of the cosmetic composition, the total content of the colorant in the phase A is 9 wt % to 13 wt %.

5. The cosmetic composition according to any one of claims 1 to 4, wherein the content of the emollient in phase A is 4 wt% to 7 wt%, calculated based on the total mass of the cosmetic composition; and / or The content of the powder dispersant in phase A is 0.5wt%-1.5wt% based on the total mass of the cosmetic composition; and / or The total content of the active ingredient is 0.010wt%-1.100wt% based on the total mass of the cosmetic composition; and / or The content of the emollient in the phase B is 2 wt % to 3 wt % based on the total mass of the cosmetic composition; and / or The content of the thickener in the phase C is 0.5wt%-1.5wt% based on the total mass of the cosmetic composition; and / or The total content of the emulsifier in the phase C is 2.5 wt%-4 wt% based on the total mass of the cosmetic composition; and / or The content of the emollient in the phase C is 8wt%-12wt% based on the total mass of the cosmetic composition; and / or The content of the film-forming agent in the phase C is 1 wt%-5 wt% based on the total mass of the cosmetic composition; and / or The content of the skin feel regulator in phase C is 1 wt%-5 wt% based on the total mass of the cosmetic composition; and / or The content of the moisturizing agent in the phase D is 8wt%-20wt% based on the total mass of the cosmetic composition; and / or The content of the antioxidant in the phase D is 0.4 wt%-0.6 wt% based on the total mass of the cosmetic composition; and / or The content of the antifreeze agent in the phase D is 0.5wt%-1.2wt% based on the total mass of the cosmetic composition; and / or The content of the thickener in the phase D is 0.03 wt % to 0.08 wt % based on the total mass of the cosmetic composition; and / or Calculated based on the total mass of the cosmetic composition, the content of water in the phase D is 31.52 wt % to 63.008 wt %.

6. The cosmetic composition according to any one of claims 1 to 3, calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 4wt%-7wt%, the content of the powder dispersant in the phase A is 0.5wt%-1.5wt%, the total content of the active ingredient is 0.010wt%-1.100wt%, the content of the emollient in the phase B is 2wt%-3wt%, the content of the thickener in the phase C is 0.5wt%-1.5wt%; the total content of the emulsifier in the phase C is 2.5wt%-4wt%, the content of the emollient in the phase C is 8wt%-12wt%, and the content of the film-forming agent in the phase C is 1wt%-5 wt%, the content of the skin feel regulator in the C phase is 1wt%-5wt%, the content of the moisturizer in the D phase is 8wt%-20wt%, the content of the antioxidant in the D phase is 0.4wt%-0.6wt%, the content of the antifreeze agent in the D phase is 0.5wt%-1.2wt%, the content of the thickener in the D phase is 0.03wt%-0.08wt%, and the balance is water; or Calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 4wt%-7wt%, the content of the powder dispersant in the phase A is 0.5wt%-1.5wt%, the total content of the active ingredient is 0.017wt%-1.100wt%, the content of the emollient in the phase B is 2wt%-3wt%, the content of the thickener in the phase C is 0.5wt%-1.5wt%; the total content of the emulsifier in the phase C is 2.5wt%-4wt%, the content of the emollient in the phase C is 8wt%-12wt%, and the content of the film-forming agent in the phase C is 1 wt%-5 wt%, the content of the skin feel regulator in the C phase is 1wt%-5wt%, the content of the moisturizer in the D phase is 8wt%-20wt%, the content of the antioxidant in the D phase is 0.4wt%-0.6wt%, the content of the antifreeze agent in the D phase is 0.5wt%-1.2wt%, the content of the thickener in the D phase is 0.03wt%-0.08wt%, and the balance is water; or Calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 4wt%, the content of the powder dispersant in the phase A is 0.5wt%, the total content of the active ingredient is 0.017wt%, the content of the emollient in the phase B is 2wt%, and the content of the thickener in the phase C is 0.5wt%; the total content of the emulsifier in the phase C is 2.5wt%, the content of the emollient in the phase C is 8wt%, the content of the film former in the phase C is 1 wt%, the content of the skin feel regulator in the phase C is 1wt%, the content of the humectant in the phase D is 20wt%, the content of the antioxidant in the phase D is 0.4wt%, the content of the antifreeze in the phase D is 0.5wt%, the content of the thickener in the phase D is 0.03wt%, and the balance is water; or Calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 5wt%, the content of the powder dispersant in the phase A is 0.9wt%, the total content of the active ingredient is 0.550wt%, the content of the emollient in the phase B is 2.5wt%, and the content of the thickener in the phase C is 1.0wt%; the total content of the emulsifier in the phase C is 3.3wt%, the content of the emollient in the phase C is 9wt%, the content of the film former in the phase C is 2.5wt%, the content of the skin feel regulator in the phase C is 2.5wt%, the content of the humectant in the phase D is 14wt%, the content of the antioxidant in the phase D is 0.5wt%, the content of the antifreeze in the phase D is 0.8wt%, the content of the thickener in the phase D is 0.05wt%, and the balance is water; or Calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 7wt%, the content of the powder dispersant in the phase A is 1.5wt%, the total content of the active ingredient is 1.100wt%, the content of the emollient in the phase B is 3wt%, and the content of the thickener in the phase C is 1.5wt%; the total content of the emulsifier in the phase C is 4wt%, the content of the emollient in the phase C is 12wt%, the content of the film former in the phase C is 5wt%, the content of the skin feel regulator in the phase C is 5wt%, the content of the humectant in the phase D is 8wt%, the content of the antioxidant in the phase D is 0.6wt%, the content of the antifreeze in the phase D is 1.2wt%, the content of the thickener in the phase D is 0.08wt%, and the balance is water; or Calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 4wt%-7wt%, the content of the powder dispersant in the phase A is 0.5wt%-1.5wt%, the total content of the colorant in the phase A is 9wt%-13wt%, the total content of the active ingredient is 0.010wt%-1.100wt%, the content of the emollient in the phase B is 2wt%-3wt%, the content of the thickener in the phase C is 0.5wt%-1.5wt%; the total content of the emulsifier in the phase C is 2.5wt%-4wt%, the content of the emollient in the phase C is 8wt%-12wt%, and the content of the film-forming agent in the phase C is 1 wt%-5 wt%, the content of the skin feel regulator in the C phase is 1wt%-5wt%, the content of the moisturizer in the D phase is 8wt%-20wt%, the content of the antioxidant in the D phase is 0.4wt%-0.6wt%, the content of the antifreeze agent in the D phase is 0.5wt%-1.2wt%, the content of the thickener in the D phase is 0.03wt%-0.08wt%, and the balance is water; or Calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 4wt%-7wt%, the content of the powder dispersant in the phase A is 0.5wt%-1.5wt%, and the total content of the colorant in the phase A is 9wt%-13wt%; the total content of the active ingredient is 0.017wt%-1.100wt%, the content of the emollient in the phase B is 2wt%-3wt%, and the content of the thickener in the phase C is 0.5wt%-1.5wt%; the total content of the emulsifier in the phase C is 2.5wt%-4wt%, the content of the emollient in the phase C is 8wt%-12wt%, and the content of the film-forming agent in the phase C is 1 wt%-5 wt%, the content of the skin feel regulator in the C phase is 1wt%-5wt%, the content of the moisturizer in the D phase is 8wt%-20wt%, the content of the antioxidant in the D phase is 0.4wt%-0.6wt%, the content of the antifreeze agent in the D phase is 0.5wt%-1.2wt%, the content of the thickener in the D phase is 0.03wt%-0.08wt%, and the balance is water; or Calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 4wt%, the content of the powder dispersant in the phase A is 0.5wt%, and the total content of the colorant in the phase A is 9wt%; the total content of the active ingredient is 0.017wt%, the content of the emollient in the phase B is 2wt%, and the content of the thickener in the phase C is 0.5wt%; the total content of the emulsifier in the phase C is 2.5wt%, the content of the emollient in the phase C is 8wt%, the content of the film former in the phase C is 1 wt%, the content of the skin feel regulator in the phase C is 1wt%, the content of the humectant in the phase D is 20wt%, the content of the antioxidant in the phase D is 0.4wt%, the content of the antifreeze in the phase D is 0.5wt%, the content of the thickener in the phase D is 0.03wt%, and the balance is water; or Calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 5wt%, the content of the powder dispersant in the phase A is 0.9wt%, and the total content of the colorant in the phase A is 11wt%; the total content of the active ingredient is 0.550wt%, the content of the emollient in the phase B is 2.5wt%, and the content of the thickener in the phase C is 1.0wt%; the total content of the emulsifier in the phase C is 3.3wt%, the content of the emollient in the phase C is 9wt%, the content of the film former in the phase C is 2.5wt%, the content of the skin feel regulator in the phase C is 2.5wt%, the content of the humectant in the phase D is 14wt%, the content of the antioxidant in the phase D is 0.5wt%, the content of the antifreeze in the phase D is 0.8wt%, the content of the thickener in the phase D is 0.05wt%, and the balance is water; or Calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 7wt%, the content of the powder dispersant in the phase A is 1.5wt%, the total content of the colorant in the phase A is 13wt%, the total content of the active ingredient is 1.100wt%, the content of the emollient in the phase B is 3wt%, and the content of the thickener in the phase C is 1.5wt%; the total content of the emulsifier in the phase C is 4wt%, the content of the emollient in the phase C is 12wt%, the content of the film former in the phase C is 5wt%, the content of the skin feel regulator in the phase C is 5wt%, the content of the humectant in the phase D is 8wt%, the content of the antioxidant in the phase D is 0.6wt%, the content of the antifreeze agent in the phase D is 1.2wt%, the content of the thickener in the phase D is 0.08wt%, and the balance is water.

7. The composition according to any one of claims 1 to 6, wherein the content of lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone is 0.5 wt% to 1.5 wt% based on the total mass of the cosmetic composition; and / or The content of the polydimethylsiloxane is 4wt%-7wt% based on the total mass of the cosmetic composition; and / or The colorant in the phase A is at least one of CI 77891, CI 77492, CI 77491, and CI 77499, and the total content of the colorant in the phase A is 9wt%-13wt% based on the total mass of the cosmetic composition; and / or Calculated based on the total mass of the cosmetic composition, the content of the tamanu oil is 0.005 wt%-0.500 wt%; and / or The content of the ceramide NP is 0.010 wt%-0.500 wt% based on the total mass of the cosmetic composition; and / or Calculated based on the total mass of the cosmetic composition, the content of the heparin sodium is 0.001 wt%-0.050 wt%; and / or Calculated based on the total mass of the cosmetic composition, the content of the Glycyrrhiza inflata extract is 0.001 wt%-0.050wt%; and / or Calculated based on the total mass of the cosmetic composition, the content of the licorice chalcone A is 0.00021wt%-0.0105wt%; and / or Calculated based on the total mass of the cosmetic composition, the content of triethylhexyl glycerol is 2wt%-3wt%; and / or The thickener in the phase C is disteardimethylammonium hectorite, and the content of the disteardimethylammonium hectorite is 0.5wt%-1.5wt% based on the total mass of the cosmetic composition; and / or The skin feel regulator in phase C is silica, and the content of silica is 1wt%-5wt% based on the total mass of the cosmetic composition; and / or The emollient in phase C is diisostearyl malate, and the content of diisostearyl malate is 7wt%-12wt% based on the total mass of the cosmetic composition; and / or The film former in phase C is trimethylsiloxysilicate, and the content of trimethylsiloxysilicate is 1 wt%-5 wt% based on the total mass of the cosmetic composition; and / or The emulsifier in the phase C includes cetyl PEG / PPG-10 / 1 polydimethylsiloxane, and the content of cetyl PEG / PPG-10 / 1 polydimethylsiloxane is 1wt%-1.5wt% based on the total mass of the cosmetic composition; and / or The emulsifier in the phase C includes lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and the content of the lauryl PEG-9 polydimethylsiloxyethyl dimethicone is 1.5wt%-2.5wt% based on the total mass of the cosmetic composition; and / or The emulsifier in phase C includes cetyl PEG / PPG-10 / 1 dimethicone and lauryl PEG-9 dimethicone, and based on the total mass of the cosmetic composition, the content of cetyl PEG / PPG-10 / 1 dimethicone is 1 wt%-1.5 wt%; the content of lauryl PEG-9 dimethicone is 1.5 wt%-2.5 wt%; and / or The moisturizer in the phase D includes glycerin; the content of the glycerin is 4wt%-6wt% based on the total mass of the cosmetic composition; and / or The moisturizer in the phase D includes 1,3-butylene glycol; the content of the 1,3-butylene glycol is 1.4 wt%-15.6 wt% based on the total mass of the cosmetic composition; and / or The moisturizer in the phase D includes 1,2-hexanediol; the content of the 1,2-hexanediol is 0.4wt%-0.6wt% based on the total mass of the cosmetic composition; and / or The moisturizer in the phase D includes glycerin, 1,3-butylene glycol and 1,2-hexanediol; based on the total mass of the cosmetic composition, the content of glycerin is 4wt%-6wt%, the content of 1,3-butylene glycol is 1.4wt%-15.6wt%, and the content of 1,2-hexanediol is 0.4wt%-0.6wt%; and / or The antioxidant in the phase D is p-hydroxyacetophenone, and the content of p-hydroxyacetophenone is 0.4wt%-0.6wt% based on the total mass of the cosmetic composition; and / or The antifreeze agent in the phase D is sodium chloride, and the content of the sodium chloride is 0.5wt%-1.2wt% based on the total mass of the cosmetic composition; and / or The thickener in the phase D is xanthan gum. The content of the xanthan gum is 0.03 wt %-0.08 wt % based on the total mass of the cosmetic composition.

8. The cosmetic composition according to any one of claims 4 to 7, wherein the active ingredients include tamanu oil, ceramide NP, sodium heparin and at least one selected from Glycyrrhiza inflata extract and Licorice Chalcone A; the powder dispersant in phase A is lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone; the emollient in phase A is dimethicone; phase A further includes a colorant; the colorant includes titanium dioxide and / or iron oxide; The emollient in the phase B is tri(ethylhexyl)glyceryl; The thickener in the phase C is disteardimonium hectorite; the skin feel regulator in the phase C is at least one of silica and silicon powder; the emollient in the phase C is diisostearyl malate; the film former in the phase C is trimethylsiloxysilicate; the emulsifier in the phase C is cetyl PEG / PPG-10 / 1 polydimethylsiloxane and lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane; The humectant in phase D is glycerol, 1,3-butylene glycol and 1,2-hexanediol; the thickener in phase D is xanthan gum; the antioxidant is p-hydroxyacetophenone; the antifreeze agent is sodium chloride; Calculated based on the total mass of the cosmetic composition, the content of the emollient in the phase A is 4wt%-7wt%, the content of the powder dispersant in the phase A is 0.5wt%-1.5wt%, the total content of the colorant in the phase A is 9wt%-13wt%, the content of the tamanu oil is 0.005wt%-0.500wt%, the content of the ceramide NP is 0.010wt%-0.500wt%, the content of the heparin sodium is 0.001wt%-0.050wt%, the content of the Glycyrrhiza inflata extract is 0.001wt%-0.050wt% or the content of the licorice chalcone A is 0.00021wt%-0.0105wt%, the content of the emollient in the phase B is 2wt%-3wt%, the content of the thickener in the phase C is 0.5wt%-1.5wt%; the cetyl PEG / PPG-10 / 1 in the phase C The content of polydimethylsiloxane is 1.0wt%-1.5wt%, the content of lauryl PEG-9 polydimethylsiloxyethyl polydimethylsiloxane in the C phase is 1.5wt%-2.5wt%, the content of the emollient in the C phase is 8wt%-12wt%, and the content of the film-forming agent in the C phase is 1wt%-5 wt%, the content of the skin feel regulator in the C phase is 1wt%-5wt%, the content of glycerol in the D phase is 4.0wt%-6.0wt%, the content of 1,3-butanediol in the D phase is 1.4wt%-15.6wt%, the content of 1,2-hexanediol in the D phase is 0.4wt%-0.6wt%, the content of the antioxidant in the D phase is 0.4wt%-0.6wt%, the content of the antifreeze agent in the D phase is 0.5wt%-1.2wt%, the content of the thickener in the D phase is 0.03wt%-0.08wt%, and the balance is water.

9. A method for preparing the cosmetic composition according to any one of claims 1 to 8, characterized in that: include: Step (1): mixing and grinding the components in phase A to obtain a phase A mixed solution; Step (2): Mix the components in phase B, heat, stir and dissolve them to obtain a phase B mixed solution; Step (3): Mix the mixed solution of phase A, the mixed solution of phase B and the components of phase C, and stir them evenly to obtain a mixed solution ABC; Step (4): Mix the components in phase D, heat and stir to dissolve, and obtain a phase D mixed solution; Step (5): heating the phase D mixed solution and the ABC mixed solution to 80-85° C., then adding the phase D mixed solution to the ABC mixed solution, stirring, homogenizing and emulsifying, and then cooling to obtain the cosmetic composition; Optionally, in step (2), the components in phase B are mixed and dissolved by stirring at 80-90° C. to obtain a phase B mixed solution; Optionally, the stirring in step (3) is carried out at 80°C-85°C; Optionally, the components in phase D in step (4) are mixed and dissolved by stirring at 80° C.-85° C. to obtain a phase D mixed solution; Optionally, the cooling in step (5) is to cool to 30°C-40°C.

10. Use of the cosmetic composition according to any one of claims 1 to 8 or the cosmetic composition prepared by the preparation method according to claim 9 in preparing cosmetics; Optionally, the cosmetic is used for moisturizing, soothing and / or anti-acne.

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