Skin care composition with anti-aging effect as well as preparation method and application of skin care composition

Abstract

The invention provides a skin care composition with an anti-aging effect as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The skin care composition is prepared from the following components in parts by weight: phosphatidylcholine, ethyoxyl diglycol, oat kernel oil, amentoflavone, a chrysanthemum extract and water. In the implementation process, the oat kernel oil, the amentoflavone and the chrysanthemum extract are added and compounded, and the mass ratio is controlled to be (10-25): 1: (5-20), so that the composition has good moisturizing, anti-aging and anti-oxidation effects, the stability of the composition can be obviously improved, and the composition is fresh and not greasy.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and specifically relates to a skin care composition with anti-aging effects, a preparation method thereof, and applications thereof. Background Art

[0002] Skin aging is a common skin problem, which is the result of the long-term combined action of multiple factors such as genetics, environment, social psychology, etc. According to the different causes of aging, it can be divided into endogenous aging and exogenous aging. Among them, resisting exogenous aging is the main way of anti-aging products. Exogenous aging refers to skin aging caused by external factors such as ultraviolet radiation, smoking, wind, sun exposure, and exposure to toxic and harmful chemicals, and ultraviolet radiation is the main factor leading to exogenous skin aging. The causes and mechanisms of skin aging are very complex. In addition to age, ultraviolet irradiation, staying up late, high mental stress, unstable emotions, excessive fatigue, etc. will all promote skin aging, mainly manifested as a reduction in skin elastic fibers and collagen fibers, and there will also be epidermal hyperkeratosis, resulting in wrinkles and age spots. The main causes of skin aging are collagen loss, free radical oxidative attack, etc. As people age, the skin becomes fragile and prone to forming wrinkles, and once wrinkles appear, they are difficult to eradicate. Due to the increasing awareness of skin care among people, the demand for cosmetics is increasing day by day, and the requirements for the efficacy of skin care products are becoming more and more strict, especially in terms of antioxidant and anti-aging effects, the demand has increased significantly. However, many products still mainly have a single efficacy, only having a single moisturizing or single anti-aging effect. Therefore, developing anti-aging skin care products with antioxidant and moisturizing effects is one of the current research hotspots.

[0003] Chinese Patent CN115645334A discloses a moisturizing and anti-aging cosmetic and a preparation method thereof. The moisturizing and anti-aging cosmetic includes the following raw materials: 1-3% of Quercus variabilis bark extract, 1-7% of butanediol, 2.2-5% of glycerol, 2.5-5% of sodium PCA, 0.3-1% of cellulose, 0.3-1% of xanthan gum, 0.3-1% of sodium hyaluronate, 0.3-1% of glyceryl caprylate, 0.05-0.2% of disodium EDTA, citric acid, sodium citrate, and deionized water. The cosmetic of this invention contains Quercus variabilis bark extract, which can effectively improve the water control and moisturizing ability and elasticity of the skin, delay skin aging, and at the same time provide a new direction for the application of native Quercus variabilis. This invention also provides a preparation method of the above cosmetic. By using this method, effective components such as phenols, small molecule sugars, amino acids, and proteins in the bark of native Quercus variabilis in China can be effectively extracted, providing technical support for the effective extraction of cork bark.

[0004] Chinese Patent CN111265454A discloses an anti-aging cosmetic composition with moisturizing and hydrating effects. The anti-aging cosmetic composition with moisturizing and hydrating effects comprises the following components in parts by weight: compound vegetable oil: 0.001 - 10 parts; fermentation product: 0.1 - 20 parts; niacinamide: 2 - 4 parts; citrus peel extract: 2 - 4 parts; soluble proteoglycan: 0.1 - 5 parts; Memecylon umbellatum leaf / stem extract: 0.1 - 5 parts; PEG / PPG - 14 / 7 dimethyl ether: 0.1 - 3 parts; sodium hyaluronate: 0.01 - 0.3 parts. Through the combined action of each component, the invention can deeply moisturize and hydrate the skin, and can also moisturize and hydrate the skin surface; it can strengthen the skin barrier function and improve the lipid structure; moreover, in terms of skin feel and usability, it is not too sticky and can provide long - lasting and deep moisturization.

[0005] However, the antioxidant and moisturizing effects of existing cosmetic compositions cannot well meet the requirements. Therefore, it is necessary to develop a skin - care composition with better antioxidant and moisturizing effects and its preparation method. Summary of the Invention

[0006] Based on the deficiencies in the prior art, the present invention aims to provide a skin - care composition with anti - aging effects, a preparation method thereof, and its application. By adding a compound of oat kernel oil, amentoflavone, and Centaurea cyanus extract, the skin - care composition not only improves the stability of the product but also makes the product have better antioxidant and anti - aging effects.

[0007] To achieve the above - mentioned technical effects, the technical solution adopted by the present invention is as follows: A skin - care composition with anti - aging effects, which is composed of the following components in parts by weight: phosphatidylcholine 2 - 10 parts, ethoxydiglycol 20 - 40 parts, oat kernel oil 2 - 10 parts, amentoflavone 0.1 - 0.5 parts, Centaurea cyanus extract 2 - 5 parts, and water 30 - 75 parts.

[0008] Preferably, the skin - care composition is composed of the following components in parts by weight: phosphatidylcholine 4 - 8 parts, ethoxydiglycol 25 - 35 parts, oat kernel oil 4 - 8 parts, amentoflavone 0.2 - 0.4 parts, Centaurea cyanus extract 2.5 - 4.5 parts, and water 40 - 65 parts.

[0009] More preferably, the skin - care composition is composed of the following components in parts by weight: phosphatidylcholine 5 - 7 parts, ethoxydiglycol 28 - 32 parts, oat kernel oil 5 - 7 parts, amentoflavone 0.3 - 0.4 parts, Centaurea cyanus extract 3 - 4 parts, and water 50 - 60 parts.

[0010] As some preferred embodiments, the mass ratio of the oat kernel oil, amentoflavone, and Centaurea cyanus extract is 10 - 25:1:5 - 20.

[0011] Preferably, the mass ratio of the oat kernel oil, amentoflavone, and the extract of Centaurea cyanus is 15 - 20:1:6 - 15.

[0012] More preferably, the mass ratio of the oat kernel oil, amentoflavone, and the extract of Centaurea cyanus is 15:1:9.

[0013] As a preferred embodiment, the skin care composition is composed of the following components by weight: 5 parts of phosphatidylcholine, 30 parts of ethoxydiglycol, 6 parts of oat kernel oil, 0.4 part of amentoflavone, 3.6 parts of the extract of Centaurea cyanus, and 55 parts of water.

[0014] The present invention also provides a method for preparing the above skin care composition, which includes the following steps: (1) Stir the oat kernel oil, amentoflavone, and the extract of Centaurea cyanus at 50 °C at a speed of 600 - 1000 rpm for 1 - 2 h until completely uniform to obtain mixture 1; (2) Stir phosphatidylcholine, ethoxydiglycol, and water at 24 °C at a speed of 600 - 1000 rpm for 10 - 20 min until completely dissolved to obtain mixture 2; (3) Mix mixture 1 and mixture 2, and stir at 24 °C at a speed of 600 - 1000 rpm for 20 - 40 min until uniformly dispersed to obtain primary emulsion; (4) The obtained primary emulsion is ultrasonically dispersed into a small - particle - size emulsion, and then homogenized to obtain the skin care composition.

[0015] The ultrasonic power is 500 - 600 W, the temperature is 50 - 60 °C, and the time is 8 - 15 minutes.

[0016] The homogenization is carried out using a microfluidic homogenizer equipped with a Z - type homogenization chamber, and the pressure for homogenization is 12000 - 18000 psi.

[0017] Preferably, the preparation method includes the following steps: (1) Stir the oat kernel oil, amentoflavone, and the extract of Centaurea cyanus at 50 °C at a speed of 800 rpm for 1.5 h until completely uniform to obtain mixture 1; (2) Stir phosphatidylcholine, ethoxydiglycol, and water at 24 °C at a speed of 800 rpm for 15 min until completely dissolved to obtain mixture 2; (3) Mix mixture 1 and mixture 2, and stir at 24 °C at a speed of 800 rpm for 30 min until uniformly dispersed to obtain primary emulsion; (4)The obtained colostrum is subjected to ultrasound with a power of 550 W, a temperature of 55 °C, and a time of 10 minutes to be dispersed into a small-particle-size emulsion, and then homogenized using a microfluidic homogenizer equipped with a Z-type homogenization chamber at a homogenization pressure of 15,000 psi to obtain the described skin care composition.

[0018] The present invention also provides the application of the above skin care composition in the preparation of cosmetics with anti-aging and moisturizing effects.

[0019] A cosmetic with anti-aging and moisturizing effects, wherein the cosmetic comprises the above skin care composition.

[0020] The cosmetic is a serum, essence water, emulsion, cream or mask.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows: (1) In the implementation process of the present invention, oat kernel oil, taxifolin and centaury extract are added. Among them, oat kernel oil is rich in unsaturated fatty acids and antioxidant components, which can effectively prevent oxidation reactions; taxifolin has good antioxidant properties and can neutralize free radicals; centaury extract contains various active ingredients and has moisturizing and antioxidant effects; the three components are compounded and the mass ratio is controlled to be 10-25:1:5-20, which can not only make the composition have good moisturizing, anti-aging and antioxidant effects, but also significantly improve the stability of the composition, and it is fresh and non-greasy.

[0022] (2) Oat kernel oil is added to the components of the present invention. Its lipid structure is similar to the skin cell membrane structure, which can promote the penetration and absorption of other components. The compounding of it with taxifolin and centaury extract can not only moisten the skin, but also help other active ingredients better penetrate into the deep layer of the skin as a carrier.

[0023] (3) The oat kernel oil and centaury extract used in the present invention are both extracted from natural plant components, have good biocompatibility, can reduce the irritation to the skin, are suitable for various skin types, and have high safety.

[0024] (4) In the preparation process of the present invention, a sonic-microfluidic tandem process is adopted, which can improve the overall stability and uniformity of the composition, and the obtained composition has a better encapsulation efficiency, and the encapsulation efficiency can reach more than 85%. Description of the Drawings

[0025] Figure 1 It is a diagram of the appearance and morphological characteristics of the skin care composition prepared in Example 5 of the present invention. Detailed Embodiments

[0026] In order to make the technical means, creative features, achieved purposes and effects of the present invention easy to understand, the present invention will be further clarified below in conjunction with specific embodiments. However, the following embodiments are only the preferred embodiments of the present invention, not all of them. Based on the embodiments in the implementation manners, other embodiments obtained by those skilled in the art without creative efforts all belong to the protection scope of the present invention. In the following embodiments, unless otherwise specified, the operation methods used are all conventional operation methods, the equipment used is all conventional equipment, the equipment materials used in each embodiment are the same, and all components are conventional components that can be obtained through commercial purchase.

[0027] The purchase manufacturers of the components used in the following embodiments are shown in Table 1 below: Table 1

[0028] Example 1 A skin care composition with anti-aging effect and its preparation method It is composed of the following components by weight: 2 parts of phosphatidylcholine, 20 parts of ethoxydiglycol, 2 parts of oat kernel oil, 0.1 part of amentoflavone, 2 parts of centaury extract and 30 parts of water.

[0029] The preparation method is as follows: (1) Stir the oat kernel oil, amentoflavone and centaury extract at 50 °C at a speed of 600 rpm for 2 h until completely uniform to obtain mixture 1; (2) Stir phosphatidylcholine, ethoxydiglycol and water at 24 °C at a speed of 600 rpm for 20 min until completely dissolved to obtain mixture 2; (3) Mix mixture 1 and mixture 2 and stir at 24 °C at a speed of 600 rpm for 40 min until evenly dispersed to obtain primary emulsion; (4) The obtained primary emulsion is ultrasonically treated at a power of 500 W, a temperature of 60 °C and a time of 15 minutes to be dispersed into a small-particle-size emulsion, and then homogenized by a microfluidic homogenizer equipped with a Z-type homogenization chamber at a pressure of 12,000 psi to obtain the skin care composition.

[0030] Example 2 A skin care composition with anti-aging effect and its preparation method It is composed of the following components by weight: 10 parts of phosphatidylcholine, 40 parts of ethoxydiglycol, 10 parts of oat kernel oil, 0.5 part of amentoflavone, 5 parts of centaury extract and 75 parts of water.

[0031] The preparation method is as follows: (1) Stir the oat kernel oil, amentoflavone and centaury extract at 50 °C at a speed of 1000 rpm for 1 h until completely uniform to obtain mixture 1; (2) Phosphatidylcholine, ethoxydiglycol and water were stirred at a speed of 1000 revolutions per minute for 10 minutes at 24 °C until completely dissolved to obtain Mixture 2; (3) Mixture 1 and Mixture 2 were mixed and stirred at a speed of 1000 revolutions per minute for 20 minutes at 24 °C until evenly dispersed to obtain the primary emulsion; (4) The obtained primary emulsion was ultrasonically treated at a power of 600 W, a temperature of 50 °C, and a time of 8 minutes to be dispersed into a small-particle-size emulsion, and then homogenized by a microfluidic homogenizer equipped with a Z-type homogenization chamber at a pressure of 18000 psi to obtain the described skin care composition.

[0032] Example 3 A skin care composition with anti-aging effect and its preparation method It is composed of the following components by weight: 4 parts of phosphatidylcholine, 35 parts of ethoxydiglycol, 4 parts of oat kernel oil, 0.4 part of amentoflavone, 2.5 parts of centaury extract, and 55 parts of water.

[0033] The preparation method is as follows: (1) Oat kernel oil, amentoflavone and centaury extract were stirred at a speed of 800 revolutions per minute for 1.5 h at 50 °C until completely uniform to obtain Mixture 1; (2) Phosphatidylcholine, ethoxydiglycol and water were stirred at a speed of 800 revolutions per minute for 15 minutes at 24 °C until completely dissolved to obtain Mixture 2; (3) Mixture 1 and Mixture 2 were mixed and stirred at a speed of 800 revolutions per minute for 30 minutes at 24 °C until evenly dispersed to obtain the primary emulsion; (4) The obtained primary emulsion was ultrasonically treated at a power of 550 W, a temperature of 55 °C, and a time of 10 minutes to be dispersed into a small-particle-size emulsion, and then homogenized by a microfluidic homogenizer equipped with a Z-type homogenization chamber at a homogenization pressure of 15000 psi to obtain the described skin care composition.

[0034] Example 4 A skin care composition with anti-aging effect and its preparation method It is composed of the following components by weight: 7 parts of phosphatidylcholine, 32 parts of ethoxydiglycol, 7 parts of oat kernel oil, 0.3 part of amentoflavone, 4 parts of centaury extract, and 60 parts of water.

[0035] The preparation method is as follows: (1) Oat kernel oil, amentoflavone and centaury extract were stirred at a speed of 800 revolutions per minute for 1.5 h at 50 °C until completely uniform to obtain Mixture 1; (2) Phosphatidylcholine, ethoxydiglycol and water were stirred at a speed of 800 revolutions per minute for 15 minutes at 24 °C until completely dissolved to obtain Mixture 2; (3) Mixture 1 and Mixture 2 were mixed and stirred at a speed of 800 revolutions per minute for 30 minutes at 24 °C until evenly dispersed to obtain the primary emulsion; (4) The obtained primary emulsion was ultrasonically treated at a power of 550 W, a temperature of 55 °C, and a time of 10 minutes to be dispersed into a small-particle-size emulsion, and then homogenized using a microfluidic homogenizer equipped with a Z-type homogenization chamber at a homogenization pressure of 15,000 psi to obtain the described skin care composition.

[0036] Example 5 A skin care composition with anti-aging efficacy and its preparation method It is composed of the following components by weight: 5 parts of phosphatidylcholine, 30 parts of ethoxydiglycol, 6 parts of oat kernel oil, 0.4 part of amentoflavone, 3.6 parts of centaury extract, and 55 parts of water.

[0037] The preparation method is as follows: (1) Oat kernel oil, amentoflavone and centaury extract were stirred at a speed of 800 revolutions per minute for 1.5 hours at 50 °C until completely homogeneous to obtain Mixture 1; (2) Phosphatidylcholine, ethoxydiglycol and water were stirred at a speed of 800 revolutions per minute for 15 minutes at 24 °C until completely dissolved to obtain Mixture 2; (3) Mixture 1 and Mixture 2 were mixed and stirred at a speed of 800 revolutions per minute for 30 minutes at 24 °C until evenly dispersed to obtain the primary emulsion; (4) The obtained primary emulsion was ultrasonically treated at a power of 550 W, a temperature of 55 °C, and a time of 10 minutes to be dispersed into a small-particle-size emulsion, and then homogenized using a microfluidic homogenizer equipped with a Z-type homogenization chamber at a homogenization pressure of 15,000 psi to obtain the described skin care composition.

[0038] Comparative Example 1 The difference from Example 5 is that the mass ratio of oat kernel oil, amentoflavone and centaury extract is 1:0.2:8.8, that is, 1 part of oat kernel oil, 0.2 part of amentoflavone and 8.8 parts of centaury extract, and the others are the same as in Example 5.

[0039] Comparative Example 2 The difference from Example 5 is that the mass ratio of oat kernel oil, amentoflavone and centaury extract is 18:0.5:1.5, that is, 9 parts of oat kernel oil, 0.25 part of amentoflavone and 0.75 part of centaury extract, and the others are the same as in Example 5.

[0040] Comparative Example 3 The difference from Example 5 is that amentoflavone and millennium chrysanthemum extract are not added, and the weight part of oat kernel oil is 10 parts, and the others are the same as in Example 5.

[0041] Comparative Example 4 The difference from Example 5 is that amentoflavone and oat kernel oil are not added, and the weight part of millennium chrysanthemum extract is 10 parts, and the others are the same as in Example 5.

[0042] Effect test: 1. Detection of encapsulation efficiency of the composition Detection method: Weigh 0.5 mL of the skin care composition prepared in Examples 1-5 and place it in a 10 mL volumetric flask, add 10% methanol solution to dilute to the scale, vortex for 3 min, demulsify, filter through a microporous membrane filter. According to the chromatographic column: WondaSil C18-WR (5 μm, 4.6×150 mm), mobile phase: acetonitrile-4% acetic acid water (62:38), flow rate: 1 mL·min -1 , the detection wavelength is 240 nm, the column temperature is 30 °C. Under these chromatographic conditions, the retention time is about 4 min, the peak shape is good, and there is no interference from impurity peaks. Inject the sample for analysis, and calculate the drug content W in the liposome 总 .

[0043] Another 1 mL of the skin care composition prepared in Examples 1-5 was taken and placed in a 10 mL volumetric flask, diluted to the mark with 10% methanol solution, shaken well, 0.5 mL was taken and placed in an ultrafiltration tube, and centrifuged at 4 °C, 12000 r·min -1 for 30 min, take the filtrate in the outer tube, and measure it under the same chromatographic conditions to calculate the free drug amount W 游 , and the encapsulation efficiency is calculated according to the following formula:

[0044] The detection results are shown in Table 2 below.

[0045] Table 2

[0046] According to the detection method in Table 2 above, by using the preparation method provided by the present invention, that is, adopting the acoustic wave-microfluidic tandem process during the preparation process, the overall stability and uniformity of the composition can be improved, and the obtained composition has a better encapsulation efficiency, so that the encapsulation efficiency can reach more than 85%.

[0047] In addition, a transmission electron microscope (TEM) was used to observe the morphological characteristics of the composition prepared in Example 5. The instrument test conditions were: the acceleration voltage was 200 kV, and the magnification was 2500x. It was observed that the morphology of the composition was regular and the bubble sizes were uniform. See specifically Figure 1 .

[0048] 2. Irritation Test Refer to SN / T 2329-2009 "Cosmetics Eye Irritation / Chorioallantoic Membrane Test of Chicken Embryo" to conduct eye irritation test (i.e., safety test) on the product.

[0049] Experimental method: Use fertilized chicken embryos within 7 days old and incubate them in an incubator at 37.6±0.5°C and 50%-70% humidity for 9 days.

[0050] Preparation of CAM: Conduct candling inspection, mark the position of the air chamber on the eggshell surface, use forceps to peel off the marked part of the eggshell to expose the white egg membrane, and operate carefully without damaging the integrity of the egg membrane. Drop 0.5 mL of 0.9% NaCl solution to fully moisten the egg membrane, gently blot the surface liquid with a tissue paper, and carefully remove the inner membrane with forceps to ensure that the vascular membrane is not damaged.

[0051] Take 0.3 ml of the transparent test substance and directly drop it onto the surface of the CAM, observe the reaction of the CAM, and record the time when each toxic effect appears within 5 minutes. Reaction endpoint method: Take 0.3 mL of the non-transparent test substance and evenly drop or smear it on the surface of the CAM. After 3 minutes, wash off the test substance with 0.9% NaCl solution and observe the degree of change of each toxic effect of the CAM.

[0052] Stimulation scoring method (irritation score IS): For the test conducted by the reaction time method, calculate the stimulation score (IS) using the formula, and retain the result to two decimal places. Classify the eye irritation of the test substance according to Table 3 based on the calculated IS value.

[0053] Irritation score IS = (301 - SecH) * 5 / 300 + (301 - SecL) * 7 / 300 + (301 - SecC) * 9 / 300 In the formula: sec H (hemorrhage time) - the average time when bleeding starts to occur observed on the CAM membrane, in seconds (s); sec L (vessel lysis time) - the average time when vessel lysis starts to occur observed on the CAM membrane, in seconds (s); sec C (coagulation time) - the average time when coagulation starts to occur observed on the CAM membrane, in seconds (s).

[0054] Table 3 Judgment Criteria for Reaction Time Results

[0055] End point score (ES): For tests using the reaction end point method, the end point score (ES) should be calculated, and the result should be retained to two decimal places. The score for each chick embryo = the sum of the degrees of hemorrhage, coagulation, and vascular lysis observed in each chick embryo, and ES = the mathematical sum of the scores of 6 chick embryos. The eye irritation of the test substance is classified according to the ES value in Table 4.

[0056] Table 4 Judgment criteria for the results of the reaction end point method

[0057] The test results are shown in Table 5 below.

[0058] Table 5

[0059] It can be seen from the test results in Table 5 above that the skin care composition prepared in this application is non-irritating and has high safety.

[0060] 3. Antioxidant performance detection Take the skin care compositions obtained in Examples 1-5 and Comparative Examples 1-4 and perform antioxidant performance detection on them. 3.1 Determination of ABTS+ scavenging ability Dilute the ABTS+ solution with phosphate buffer (10 mmol / L, pH 7.4) to make its absorbance at 734 nm wavelength be 0.700 ± 0.020, that is, obtain the ABTS+ working solution. Take 1 mL of the skin care composition sample into a test tube respectively, add 3 mL of the ABTS+ working solution, mix well, store in the dark at room temperature for 10 min, and measure the absorbance at 734 nm (using phosphate buffer as the blank control). Each sample is made into 3 parallel samples, and the clearance rate calculation formula is as follows: Clearance rate (%) = × 100% Among them, Ai is the absorbance value of 1 mL of sample solution + 3 mL of ABTS+ solution; Aj is the absorbance value of 1 mL of sample solution + 3 mL of phosphate buffer; Ac is the absorbance value of 1 mL of phosphate buffer + 3 mL of ABTS+ solution. 3.2 Determination of hydroxyl radical scavenging ability In 0.40 mL of 6 mmol / L ferrous sulfate solution, add 1 mL of 8.8 mmol / L hydrogen peroxide solution, then add 1 mL of 9 mmol / L salicylic acid solution and 1.60 mL of distilled water. Mix well and heat in a water bath at 37 °C for 15 min (using distilled water as the blank control). Measure the absorbance value Ac at a wavelength of 510 nm. Ai is the absorbance value measured with the skin care composition sample replacing 1.60 mL of distilled water. Take 1 mL of distilled water to replace the hydrogen peroxide solution and measure the absorbance value as Aj. The Vc solution is used as a positive control to calculate the scavenging rate of the sample for hydroxyl radicals. Scavenging rate (%) = × 100% 3.3. Determination of superoxide anion radical scavenging ability Add 1 mL of distilled water to 1.40 mL of Tris-HCl buffer solution (0.05 mol / L, pH 8.2), then add 0.2 mL of 5 mmol / L pyrogallol solution. Mix well and let stand for 5 min, then measure the absorbance value Ac at a wavelength of 320 nm. Ai is the absorbance value measured with the skin care composition sample replacing 1 mL of distilled water. Take 0.2 mL of 10 mmol / L hydrochloric acid solution to replace the pyrogallol solution and measure the absorbance value as Aj. Each sample is tested in triplicate to calculate the scavenging rate of the sample for superoxide anion radicals. Scavenging rate (%) = × 100% The results are shown in Table 6 below.

[0061] Table 6

[0062] According to the test results in Table 6 above, it can be seen that the skin care compositions prepared in Examples 1-5 of the invention have good scavenging abilities for ABTS⁺, hydroxyl radicals and superoxide anion radicals. Among them, the skin care composition prepared in Example 5 has the best scavenging abilities for ABTS⁺, hydroxyl radicals and superoxide anion radicals. Changing the mass ratio between components in Comparative Examples 1-2 will affect the scavenging ability of the skin care composition for free radicals to a certain extent, and changing the types of components in Comparative Examples 3-4 will significantly affect the scavenging ability of the skin care composition for free radicals.

[0063] 4. In vitro moisturizing performance study - water loss rate detection Experimental method: (1) 12 h before the experiment, prepare a supersaturated solution of magnesium chloride or calcium chloride to create a constant humidity environment with a relative humidity of 30%. (2) Mark the weighing bottle, place it in an oven at 105 °C and dry it to a constant weight. After it cools to room temperature, weigh it. Record it as m1. Weigh an appropriate amount of the skin care compositions prepared in Examples 1-5 and Comparative Examples 1-4 respectively, and make the liquid level just cover the bottom of the bottle, which is recorded as m2 (weighing bottle + sample). Place the weighing bottle containing the sample in a humidity chamber (calcium chloride supersaturated solution) with a humidity of about 30% and leave it for 3 h. (3) After leaving it for 3 h, quickly take out the sample and weigh it, which is recorded as m3 (weighing bottle + sample). (4) Calculate the water loss rate of the sample.

[0064] Water loss rate = (m2 - m3) / (m2 - m1) × 100% The test results are shown in Table 7 below.

[0065] Table 7

[0066] According to the test results in Table 7 above, it can be seen that the skin care compositions prepared in Examples 1-5 of the present invention have better water retention effects. In Comparative Examples 1-2, changing the mass ratio between components has little effect on the water retention effect of the skin care composition, but changing the component types in Comparative Examples 3-4 will affect the water retention property of the skin care composition.

[0067] The above is a further description of the present invention in combination with specific embodiments, but these embodiments are merely exemplary and do not constitute any limitation to the scope of the present invention. Those skilled in the art should understand that without departing from the spirit and scope of the present invention, modifications or substitutions can be made to the details and forms of the technical solutions of the present invention, but these modifications and substitutions all fall within the protection scope of the present invention.

Claims

1. A skin care composition with anti-aging effect, characterized in that: The invention is composed of the following components by weight: 2-10 parts of phosphatidylcholine, 20-40 parts of ethoxydiglycol, 2-10 parts of oat kernel oil, 0.1-0.5 parts of aconitum flavonoids, 2-5 parts of spilionella extract and 30-75 parts of water; the mass ratio of the oat kernel oil, aconitum flavonoids and spilionella extract is 10-25:1:5-20.

2. The skin care composition according to claim 1, characterized in that: The invention comprises the following components by weight: 4-8 parts of phosphatidylcholine, 25-35 parts of ethoxydiglycol, 4-8 parts of oat kernel oil, 0.2-0.4 parts of aconitum biflavonoids, 2.5-4.5 parts of spilionella extract and 40-65 parts of water.

3. The skin care composition according to claim 1, characterized in that: The mass ratio of the oat kernel oil, aconitum biflavonoids and spilionella extract is 15-20:1:6-15.

4. The skin care composition according to claim 1, characterized in that: The mass ratio of the oat kernel oil, aconitum flavonoids and spilionella extract is 15:1:

9.

5. The skin care composition according to claim 4, characterized in that: The following components are included in parts by weight Composition: 5 parts of phosphatidylcholine, 30 parts of ethoxydiglycol, 6 parts of oat kernel oil, 0.4 parts of aconitum biflavonoids, 3.6 parts of spilionella extract and 55 parts of water.

6. The method for preparing the skin care composition according to any one of claims 1 to 5, characterized in that: The steps include: (1) stirring oat kernel oil, aconitum biflavonoids and spilionella extract at 50° C. and at a speed of 600-1000 rpm for 1-2 h until completely homogeneous, to obtain a mixture 1; (2) stirring phosphatidylcholine, ethoxydiglycol and water at 24° C. at a speed of 600-1000 rpm for 10-20 min until all of the phosphatidylcholine is dissolved, to obtain a mixture 2; (3) Mixing mixture 1 and mixture 2, stirring at 24°C at a speed of 600-1000 rpm for 20-40 min until the mixture is evenly dispersed, to obtain colostrum; (4) The obtained colostrum is dispersed into a small particle size emulsion by ultrasonic dispersion, and then homogenized to obtain the skin care composition.

7. The preparation method according to claim 6, characterized in that: The ultrasonic power is 500-600W, the temperature is 50-60°C, and the time is 8-15 minutes; the homogenization is performed by a microfluidizer equipped with a Z-shaped homogenization chamber, and the homogenization pressure is 12000-18000psi.

8. Use of the skin care composition according to any one of claims 1 to 5 in the preparation of cosmetics with anti-aging and moisturizing effects.

9. A cosmetic with anti-aging and moisturizing effects, characterized in that: The cosmetic comprises the skin care composition according to any one of claims 1 to 5.

10. The cosmetic according to claim 9, characterized in that: The cosmetics are essence, essence water, emulsion, cream or facial mask.

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