Soothing and moisturizing composition and soothing and moisturizing daily chemical wash supplies

Abstract

The invention relates to the technical field of preparation of soothing and moisturizing components for cosmetics, and particularly discloses a soothing and moisturizing composition and soothing and moisturizing daily chemical washing supplies, the soothing composition is composed of cedar wood oil, rhizoma drynariae extract, black mulberry fruit extract, polygonum multiflorum extract and menthol, the invention further provides a soothing and moisturizing daily chemical washing and chemical product comprising the soothing and moisturizing composition. The traditional Chinese medicine composition can help people to relieve the problems of dry skin, pruritus and the like after exercises, promote blood circulation and accelerate discharge of metabolic waste after exercises.

Description

Technical Field

[0001] The present invention relates to the field of washing and care products, and particularly to a soothing and moisturizing composition and a soothing and moisturizing daily chemical washing and care product. Background Art

[0002] With the accelerating pace of modern life, many people have begun to realize that exercise can relieve the stress of life, improve the mood of life, and enhance the quality of life. However, after long-term relatively intense exercise, some minor injuries may also occur. If not repaired in time, over time, some significant problems may arise. For example: (1) A large amount of sweating during exercise is likely to irritate the skin, causing skin problems such as pore blockage and skin itching; (2) A large amount of sweating will also affect the scalp environment. The sweat and oil on the scalp are mixed. If not cleaned in time, it may block the hair follicles, and in severe cases, it may lead to seborrheic dermatitis or hair loss; (3) Excessive exercise is also likely to cause physical fatigue, muscle tension or soreness. According to the usual habit, after exercise, people often wash their hair and take a bath to do a good job in cleaning. However, simple cleaning often fails to solve a series of problems that may exist in the skin and muscles after exercise, such as dry or itchy skin, muscle tension or soreness. Based on this, if a daily chemical washing and care product that can help people solve the above problems can be developed, it will be of great benefit to people to maintain their exercise state and relieve the stress of life. Summary of the Invention

[0003] The present invention provides a soothing and moisturizing composition and a soothing and moisturizing daily chemical washing and care product, which can help people relieve problems such as dry and itchy skin after exercise, and promote blood circulation and accelerate the excretion of metabolic wastes after exercise.

[0004] To achieve the above object, the technical solution of the present invention is as follows:

[0005] A soothing and moisturizing composition, wherein the soothing and moisturizing composition is composed of cedarwood oil, drynaria rhizome extract, black mulberry fruit extract, polygonum multiflorum extract and menthol in a weight ratio of 1-4:1-4:1-6:1-6:1-2.

[0006] Preferably, the soothing and moisturizing composition is composed of cedarwood oil, drynaria rhizome extract, black mulberry fruit extract, polygonum multiflorum extract and menthol in a weight ratio of 1:1:1.5:1.5:1.25.

[0007] Preferably, the drynaria rhizome extract is an ethanol extract; the black mulberry fruit extract is an ethanol extract; the polygonum multiflorum extract is an ethanol extract.

[0008] Preferably, the weight of the Drynaria fortunei extract is calculated based on its weight concentrated to 1 / 2 to 1 times the weight of the crude drug; and / or the weight of the black mulberry fruit extract is calculated based on its weight concentrated to 1 / 2 to 1 times the weight of the crude drug; and / or the weight of the Polygonum multiflorum extract is calculated based on its weight concentrated to 1 / 2 to 1 times the weight of the crude drug.

[0009] Preferably, the preparation method of the Drynaria fortunei extract and / or the black mulberry fruit extract and / or the Polygonum multiflorum extract comprises the following steps:

[0010] (1) Weigh the crude medicinal materials, pulverize them, add a 5 - 10 wt% sodium bicarbonate solution with a weight 2 - 5 times that of the crude medicinal materials, and soak for at least 30 min to obtain a medicinal material soaking solution;

[0011] (2) Add an 80 - 90% vol. ethanol solution with a weight 2 - 5 times that of the medicinal material soaking solution to obtain a medicinal material mixed extraction material, then add 2,6 - di - tert - butyl - p - cresol at 0.05 - 0.1 wt% of the weight of the medicinal material mixed extraction material, heat under reflux for 2 - 3 hours, and separate out the medicinal material ethanol extract; repeat the above steps 1 - 3 times, and combine the medicinal material ethanol extracts;

[0012] (3) Take the combined medicinal material ethanol extracts, concentrate them to 1 / 2 to 1 times the weight of the crude medicinal materials to obtain the corresponding medicinal material extracts.

[0013] Of course, the extraction method of the above extracts is not limited to the above - described method, and other methods such as supercritical extraction and ultrasonic extraction can also be used for extraction.

[0014] A soothing and moisturizing daily chemical washing and care product comprises the above - described soothing and moisturizing composition.

[0015] Preferably, the soothing and moisturizing composition is added as the only soothing and moisturizing active ingredient in the daily chemical washing and care product, and the weight percentage of the soothing and moisturizing composition added in the daily chemical washing and care product is 0.0025 - 3%.

[0016] Preferably, the daily chemical washing and care product is shampoo, hair conditioner, soap, hand sanitizer or body wash.

[0017] In the soothing composition of the present invention, each component has the following functions:

[0018] Cedarwood oil, an essential oil extracted from the bark, trunk or wood of Cedrus by distillation, has astringent, antibacterial, sedative and other effects.

[0019] Drynaria fortunei, the dry rhizome of Davallia trichomanoides Blume of the family Drynariaceae, is bitter in taste and warm in nature; it has the effects of tonifying the kidney, promoting blood circulation and stopping bleeding.

[0020] Black mulberry fruit, also known as mulberry, tastes sweet and flat, with a slightly cold nature; it has the effects of nourishing blood and yin, promoting fluid production to quench thirst, and moistening the intestines and relieving constipation.

[0021] Polygonum multiflorum: The dried tuberous root of Polygonum multiflorum Thunb. of the genus Polygonum in the Polygonaceae family, tastes pungent, with a slightly warm nature; it has the effects of tonifying essence and blood, detoxifying and treating malaria, and loosening the bowels and relieving constipation.

[0022] Menthol: Naturally sourced from the crystalline substance refined by distillation from the dried aerial parts of the herb Mentha haplocalyx Briq. of the Lamiaceae family; it has the effect of relieving itching with a cool sensation.

[0023] The above-mentioned soothing and moisturizing composition and soothing and moisturizing daily chemical washing and care products have the following advantages:

[0024] Cedarwood oil, Drynaria fortunei extract, black mulberry fruit extract, Polygonum multiflorum extract, and menthol are selected for compounding. After experimental verification, the soothing and moisturizing composition and soothing and moisturizing daily chemical washing and care products of the present invention can help people relieve symptoms such as skin dryness and itching after exercise, promote blood circulation, thereby accelerating the metabolism of lactic acid, and alleviating problems such as muscle tension or soreness after exercise, and have a significant soothing effect. Detailed implementation mode

[0025] To make the objectives, technical solutions, and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the scope of protection of the present invention.

[0026] A soothing and moisturizing composition, wherein the soothing and moisturizing composition is composed of cedarwood oil, Drynaria fortunei extract, black mulberry fruit extract, Polygonum multiflorum extract, and menthol in a weight ratio of 1-4:1-4:1-6:1-6:1-2 (such as 4:4:3:3:1, 4:4:6:6:1, 1:1:1:1:1, 3:3:2:2:1, 2:2:1.5:1.5:1, 1:1:1.5:1.5:1.25, or 2:3:2:1:1).

[0027] Preferably, the soothing and moisturizing composition is composed of cedarwood oil, Drynaria fortunei extract, black mulberry fruit extract, Polygonum multiflorum extract, and menthol in a weight ratio of 1:1:1.5:1.5:1.25.

[0028] Preferably, the Drynaria fortunei extract is an ethanol extract; and / or the black mulberry fruit extract is an ethanol extract; and / or the Polygonum multiflorum extract is an ethanol extract.

[0029] Preferably, the weight of the Drynaria fortunei extract is calculated as its weight concentrated to 1 / 2 to 1 (e.g., 1 / 2, 2 / 3, 4 / 5 or 1) of the weight of the original drug; and / or the weight of the black mulberry fruit extract is calculated as its weight concentrated to 1 / 2 to 1 (e.g., 1 / 2, 2 / 3, 4 / 5 or 1) of the weight of the original drug; and / or the weight of the Polygonum multiflorum extract is calculated as its weight concentrated to 1 / 2 to 1 (e.g., 1 / 2, 2 / 3, 4 / 5 or 1) of the weight of the original drug.

[0030] Preferably, the preparation method of the Drynaria fortunei extract and / or the black mulberry fruit extract and / or the Polygonum multiflorum extract comprises the following steps:

[0031] (1) Weigh the original medicinal materials, crush them, add a 5 - 10 wt% sodium bicarbonate solution with a weight 2 - 5 times that of the original materials and soak for at least 30 min to obtain a medicinal material soaking solution;

[0032] (2) Add an 80 - 90% vol. ethanol solution with a weight 2 - 5 times that of the medicinal material soaking solution to obtain a medicinal material mixed extraction material, then add 2,6 - di - tert - butyl - p - cresol with a weight of 0.05 - 0.1 wt% of the medicinal material mixed extraction material, heat under reflux for 2 - 3 hours, and separate out the medicinal material ethanol extract; repeat the above steps 1 - 3 times and combine the medicinal material ethanol extracts;

[0033] (3) Take the combined medicinal material ethanol extracts, concentrate them to 1 / 2 to 1 times the weight of the original medicinal materials to obtain the corresponding medicinal material extracts.

[0034] Of course, the extraction method of the above extracts is not limited to the method described above, and other methods such as supercritical extraction and ultrasonic extraction can also be used for extraction.

[0035] A soothing and moisturizing daily chemical washing and care product comprises the soothing and moisturizing composition described above.

[0036] Preferably, the soothing and moisturizing composition is added as the only soothing and moisturizing active ingredient in the daily chemical washing and care product, and the weight percentage of the soothing and moisturizing composition added in the daily chemical washing and care product is 0.0025 - 3% (e.g., 0.0025%, 0.005%, 0.1%, 1% or 3%).

[0037] Preferably, the daily chemical washing and care product is shampoo, hair conditioner, soap, hand sanitizer or body wash.

[0038] The present invention will be further described by way of examples below, but the protection scope of the present invention is not limited to these embodiments.

[0039] In this embodiment, the preparation methods of the drynaria rhizome extract, black mulberry fruit extract and fleeceflower root extract are as follows: (1) Respective original medicinal materials are taken and pulverized, and soaked in a 10 wt% sodium bicarbonate solution with a weight 2 times that of the original medicinal materials for 1 h to obtain a medicinal material soaking solution; (2) An 85% vol. ethanol solution with a weight 5 times that of the medicinal material soaking solution is added to obtain a medicinal material mixed extraction material, and then 2,6-di-tert-butyl-p-cresol with a weight 0.05 wt% of the medicinal material mixed extraction material is added, and heating and reflux extraction are performed at 80 °C for 2 h to separate out a medicinal material ethanol extract; the above step is repeated once, and the medicinal material ethanol extracts are combined; (3) The combined medicinal material ethanol extract is taken and concentrated to 1 / 2 times the weight of the original medicinal materials to obtain the corresponding medicinal material extract.

[0040] The soothing and moisturizing composition is obtained by mixing cedarwood oil, drynaria rhizome extract, black mulberry fruit extract, fleeceflower root extract and menthol in a certain proportion to obtain a sports soothing composition.

[0041] I. Test for the soothing and moisturizing effects of the sports soothing and moisturizing composition

[0042] 1.1 Soothing test for the sports soothing composition: Inhibition of neutrophil aggregation in zebrafish embryos

[0043] Neutrophils in zebrafish embryos are highly similar to human neutrophils in terms of morphology, biochemistry and physiological functions. Neutrophils are the first white blood cells to appear at the site of injury or pathogen invasion, and function to remove infections or harmful substances. A model in which copper sulfate is used to induce the injury of neuromast cells in the lateral line region of zebrafish embryos and cause neutrophil aggregation is used for testing. The changes in the number of neutrophils in the lateral line region of the fish embryos in the test substance treatment group and the blank control group are compared, and then the neutrophil inhibition rate is calculated to evaluate the soothing effect of the raw materials, formulations or products.

[0044] A model in which copper sulfate is used to induce the injury of neuromast cells in the lateral line region of zebrafish embryos and cause neutrophil aggregation is used for testing. 20 fish embryos are taken for testing in each treatment group. The fish embryos are respectively exposed to 10 μM anhydrous copper sulfate, different soothing and moisturizing compositions (1#, 2#, 3#, 4# soothing and moisturizing compositions) with different added concentrations (0.1%, 0.15%, 0.2%, 0.3%, 1%). At the same time, a blank control group (fish embryo culture solution), a model control group (copper sulfate working solution) and a positive control group (10 μM indomethacin) are set. After 40 min of exposure, the fish embryos are fixed and stained with Sudan black, and the number of neutrophils in the lateral line region is counted and statistically analyzed. The greater the neutrophil inhibition rate, the better the soothing effect.

[0045] Calculate the neutrophil aggregation inhibition rate:

[0046]

[0047] In the formula:

[0048] S—the average number of neutrophils in the fish embryos of the test substance treatment group, with the unit of grains per fish (grains / fish);

[0049] M—the average number of neutrophils in the fish embryos of the model control group, with the unit of grains per fish (grains / fish);

[0050] B—the average number of neutrophils in the fish embryos of the blank control group, with the unit of grains per fish (grains / fish);

[0051] Calculate the average value of each test group.

[0052] Table 1 Composition of the soothing composition

[0053]

[0054] Table 2 Soothing effect test of 5 components and mixed components (neutrophil inhibition rate, %)

[0055]

[0056]

[0057] 1.2 Moisturizing test of the moisturizing composition: Water loss inhibition test of zebrafish embryos

[0058] Neutrophils in zebrafish embryos are highly similar to human neutrophils in terms of morphology, biochemistry, and physiological functions. Neutrophils are the first white blood cells to appear at the site of injury or pathogen invasion, and their function is to remove infectious or harmful substances. A model of inducing neutrophil aggregation by damaging neuromast cells in the lateral line region of zebrafish embryos with copper sulfate was used for testing. The changes in the number of neutrophils in the lateral line region of fish embryos in the test substance treatment group and the blank control group were compared, and then the neutrophil inhibition rate was calculated to evaluate the soothing efficacy of raw materials, formulations, or products. A water loss induction model was tested by increasing the osmotic pressure of the fish embryo culture solution. Twenty-four 3-day-old zebrafish embryos were respectively exposed to different soothing and moisturizing compositions (1#, 2#, 3#, 4# soothing and moisturizing compositions) with different added concentrations (0.1%, 0.15%, 0.2%, 0.3%, 1%), and at the same time, a blank control group (fish embryo culture solution / solvent solution), a model control group (water loss model inducer solution), and a positive control group (0.5% glycerol) were set. After 3 hours of exposure, the fish embryos were photographed under a microscope to measure the tail area and statistical analysis was carried out.

[0059] Calculate the inhibition rate of tail area reduction:

[0060]

[0061] In the formula:

[0062] S—the average value of the tail area of fish embryos in the test substance treatment group;

[0063] B—the average value of the tail area of fish embryos in the blank control group;

[0064] M—the average value of the tail area of fish embryos in the model control group.

[0065] Calculate the average value of each test group.

[0066] Table 3 Composition of the moisturizing composition

[0067]

[0068]

[0069] Table 4 Moisturizing effect test of 5 components and their mixed components (inhibition rate of zebrafish embryo tail shrinkage, %)

[0070]

[0071] II. Soothing test of body wash and shampoo

[0072] 2.1 Preparation of soothing body wash: Apply the above-mentioned No. 4 soothing and moisturizing composition to the body wash.

[0073] Examples 1 to 5 are the raw materials and their weight percentage contents formulated into body wash, as shown in Table 5:

[0074] Table 5 Formula of soothing and moisturizing body wash

[0075]

[0076]

[0077] 2.2 Preparation of soothing shampoo: Apply the above-mentioned No. 4 soothing and moisturizing composition to the shampoo.

[0078] Examples 6 to 10 are the raw materials and their weight percentage contents formulated into soothing and moisturizing shampoo, as shown in Table 6:

[0079] Table 6 Formula of soothing and moisturizing shampoo

[0080]

[0081] 2.3 Soothing test of soothing and moisturizing body wash and soothing and moisturizing shampoo

[0082] Test was conducted using a model of neutrophil aggregation induced by copper sulfate-induced injury of neuromast cells in the lateral line region of zebrafish embryos. 20 fish embryos were taken for testing in each treatment group. The fish embryos were respectively exposed to 10 μM anhydrous copper sulfate, the shower gels or shampoos of Examples 1-10 (shower gel: the concentration of the 4# soothing and moisturizing composition was 0.1%, 0.4%, 0.7%, 1%, 1.3%; shampoo: the concentration of the 4# soothing and moisturizing composition was 0.1%, 0.5%, 1.0%, 2.0%,

[0083] 3.0%). Meanwhile, a blank control group (fish embryo culture medium), a model control group (copper sulfate working solution), and a positive control group (10 μM indomethacin) were set up. After 40 minutes of exposure, the fish embryos were fixed and stained with Sudan black, and the number of neutrophils in the lateral line region was counted and statistically analyzed. The greater the neutrophil inhibition rate, the better the soothing effect.

[0084] Table 7 Neutrophil inhibition rate of shower gel

[0085]

[0086] Table 8 Neutrophil inhibition rate of shampoo

[0087]

[0088] The test results proved that: the shower gels or shampoos of this example could significantly inhibit neutrophil aggregation in zebrafish embryos and had a soothing effect.

[0089] 2.4 Moisturizing test of soothing and moisturizing shower gel and soothing and moisturizing shampoo

[0090] Test was conducted using a model of neutrophil aggregation induced by copper sulfate-induced injury of neuromast cells in the lateral line region of zebrafish embryos. The change in the number of neutrophils in the lateral line region of fish embryos in the test substance treatment group and the blank control group was compared, and then the neutrophil inhibition rate was calculated to evaluate the soothing efficacy of the raw materials, formulations or products. Test was conducted using a model of induced water loss by increasing the osmotic pressure of the fish embryo culture medium. 24 three-day-old zebrafish embryos were respectively exposed to the shower gels or shampoos of Examples 1-10 (shower gel: the concentration of the 4# soothing and moisturizing composition was 0.1%, 0.4%, 0.7%, 1%, 1.3%; shampoo: the concentration of the 4# soothing and moisturizing composition was 0.1%, 0.5%, 1.0%, 2.0%, 3.0%). Meanwhile, a blank control group (fish embryo culture medium / solvent solution), a model control group (water loss model inducer solution), and a positive control group (0.5% glycerol) were set up. After 3 hours of exposure, the fish embryos were photographed under a microscope to measure the tail area and statistically analyzed.

[0091] The greater the inhibition rate of zebrafish embryo tail shrinkage, the better the moisturizing effect.

[0092] Table 9 Inhibition rate of zebrafish embryo tail shrinkage by shampoo

[0093]

[0094] Table 10 Inhibition rate of zebrafish embryo tail shrinkage by body wash

[0095]

[0096] The test results prove that: the body wash or shampoo of this example can significantly inhibit the shrinkage of zebrafish embryo tails and has a moisturizing effect.

[0097] III. Effect of promoting blood circulation

[0098] Substances with the effect of promoting blood circulation can effectively soothe the skin, which is the mechanism of action for soothing the skin. The zebrafish embryo is transparent throughout, and has become a classic research model for human cardiovascular-related research. Under a microscope, the flow of blood cells in blood vessels is clearly visible. Therefore, zebrafish embryos are very suitable for testing the effect of promoting blood circulation of samples, and the effect of promoting blood circulation of samples is evaluated by measuring and calculating the blood circulation promotion rate of the tail artery of zebrafish embryos.

[0099] Twenty 3-day-old zebrafish embryos were respectively exposed to the body wash or shampoo of Examples 1-10 (body wash: concentrations of 4# soothing and moisturizing composition 0.1%, 0.4%, 0.7%, 1%, 1.3%; shampoo: concentrations of 4# soothing and moisturizing composition 0.1%, 0.5%, 1.0%, 2.0%, 3.0%) solutions. At the same time, a blank control group (fish embryo culture solution) and a positive control group (0.1 μg / mL digoxin solution) were used. After 2 hours of exposure, each zebrafish embryo tail aortic blood vessel was photographed under a microscope for 20 s. Then, software was used to analyze the blood flow velocity in the tail aortic blood vessel of each fish embryo, and the average value was taken and statistically analyzed. Blood circulation promotion rate of the tail aorta of zebrafish embryos.

[0100] Calculate the blood circulation promotion rate:

[0101]

[0102] In the formula:

[0103] S—the average value of the relative blood flow velocity of the tail aorta of fish embryos in the test substance treatment group;

[0104] B—the average value of the relative blood flow velocity of the tail aorta of fish embryos in the blank control group.

[0105] Table 11 Blood circulation promotion rate of the tail aorta of zebrafish embryos by shampoo

[0106]

[0107] Table 12 Promotion rate of caudal aortic blood circulation in zebrafish embryos by body wash

[0108]

[0109] The test results prove that: the body wash or shampoo of this embodiment can significantly promote the blood flow velocity of zebrafish embryos, has the effect of promoting blood circulation, and can be used as supporting evidence for the efficacy of promoting blood circulation.

Claims

1. A soothing and moisturizing composition, characterized in that: The soothing and moisturizing composition is composed of cedarwood oil, drynaria extract, black mulberry extract, polygonum multiflorum extract and menthol in a weight ratio of 1-4:1-4:1-6:1-6:1-2.

2. The soothing and moisturizing composition according to claim 1, characterized in that: The soothing and moisturizing composition consists of cedarwood oil, drynaria extract, black mulberry extract, polygonum multiflorum extract and menthol in a weight ratio of 1:1:1.5:1.5:1.

25.

3. The soothing and moisturizing composition according to claim 1, characterized in that: The Rhizoma Drynariae extract is an ethanol extract; and / or the Morus Nigra extract is an ethanol extract; and / or the Polygonum multiflorum extract is an ethanol extract.

4. The soothing and moisturizing composition according to claim 1, characterized in that: The weight of the Drynaria fortunei extract is calculated by concentrating its weight to 1 / 2 to 1 of the original drug weight; and / or the weight of the Morus alba extract is calculated by concentrating its weight to 1 / 2 to 1 of the original drug weight; and / or the weight of the Polygonum multiflorum extract is calculated by concentrating its weight to 1 / 2 to 1 of the original drug weight.

5. The soothing and moisturizing composition according to claim 4, characterized in that: The preparation method of the Rhizoma Drynariae extract and / or the Morus Nigra extract and / or the Polygonum multiflorum extract comprises the following steps: (1) Weigh the original medicinal material, crush it, add 2 to 5 times the weight of 5 to 10 wt% sodium bicarbonate solution and soak it for at least 30 minutes to obtain a medicinal material soaking solution; (2) adding 80-90% vol. ethanol solution in an amount of 2-5 times the weight of the medicinal material soaking liquid to obtain a mixed medicinal material extraction material, and then adding 0.05-0.1wt% of 2,6-di-tert-butyl-p-methylphenol in an amount of 0.05-0.1wt% by weight of the mixed medicinal material extraction material, heating and refluxing for 2-3 hours, and separating the medicinal material alcohol extract; repeating the above steps 1-3 times, and combining the medicinal material alcohol extracts; (3) Take the combined medicinal material alcohol extract and concentrate it to 1 / 2 to 1 times the weight of the original medicinal material to obtain the corresponding medicinal material extract.

6. A soothing and moisturizing daily cleaning product, characterized in that: The soothing and moisturizing composition comprises the soothing and moisturizing composition according to any one of claims 1 to 5.

7. The soothing and moisturizing daily chemical cleaning product according to claim 6, characterized in that: The soothing and moisturizing composition is added to the daily chemical cleaning product as the only soothing and moisturizing active ingredient, and the weight percentage of the soothing and moisturizing composition added to the daily chemical cleaning product is 0.0025-3%.

8. The soothing and moisturizing daily chemical cleaning product according to claim 6, characterized in that: The daily chemical cleaning products are shampoo, conditioner, soap, hand soap or shower gel.

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