Biomass nano-composite for relieving rhinitis and preparation method of biomass nano-composite

Abstract

The invention discloses a biomass nano-composite for relieving rhinitis and a preparation method thereof, and belongs to the field of new materials, the biomass nano-composite comprises a dressing containing a biomass nano-drug layer, the dressing comprises a fixed glue layer and a movable glue layer which are bonded with each other, and the biomass nano-drug layer is adsorbed on the movable glue layer; the fixed adhesive layer comprises a flexible base material, a bottom adhesive layer is adhered to one side surface of the flexible base material, and a surface adhesive layer is adhered to the other side surface of the flexible base material; the bottom adhesive layer comprises a methyl methacrylate grafted and modified SIS (styrene isoprene styrene) hot-melt pressure-sensitive adhesive, hyaluronic acid silica gel and nano magnesium aluminum silicate; the surface adhesive layer comprises a benzophenone photoinitiator, an acrylic acid grafted and modified SIS hot-melt pressure-sensitive adhesive, nano titanium dioxide, quaternary ammonium salt modified chitosan and N, N '-methylene bisacrylamide; the movable glue layer comprises a hydrogel drug carrier, and the biomass nano-drug layer is adsorbed on the hydrogel drug carrier. The skin can be effectively prevented from being damaged due to repeated pulling by the adhesive layer.

Description

Technical Field

[0001] The present invention belongs to the field of new materials and relates to a biomass nanocomposite for relieving rhinitis and a preparation method thereof. Background Art

[0002] There are many types of rhinitis dressings for relieving rhinitis by applying on the nose. The most common one is the rhinitis patch. The rhinitis patch includes a drug layer and an adhesive layer. The drugs in the drug layer have skin permeability or are volatile adsorption type. It is convenient to use and can relieve the discomfort of rhinitis.

[0003] In the existing rhinitis patch, the drug layer and the adhesive layer are of an integral structure. In order to ensure the close fit between the adhesive layer and the skin, there is a relatively high peel strength between the adhesive layer and the skin. When the drug loses its efficacy, the whole rhinitis patch needs to be replaced. If the whole rhinitis patch is frequently replaced within a period of time, the adhesive layer of the rhinitis patch will repeatedly pull the skin, causing skin damage. Especially for volatile drugs with a short efficacy time, the rhinitis patch will be frequently replaced in a short time, and the damage to the skin is obvious. Summary of the Invention

[0004] The purpose of the present invention is to provide a biomass nanocomposite for relieving rhinitis and a preparation method thereof, which solves the problem that in the existing rhinitis patch, the drug layer and the adhesive layer are of an integral structure. When the drug loses its efficacy, the whole rhinitis patch needs to be replaced. If the rhinitis patch is frequently replaced in a short time, the adhesive layer of the rhinitis patch will repeatedly pull the skin, causing skin damage.

[0005] The technical solution adopted by the present invention is as follows:

[0006] A biomass nanocomposite for relieving rhinitis, comprising a dressing containing a biomass nano-drug layer. The dressing includes a fixed adhesive layer and a movable adhesive layer that are adhesively bonded to each other. The biomass nano-drug layer is adsorbed on the movable adhesive layer. The fixed adhesive layer includes a flexible substrate. One side surface of the flexible substrate is adhesively bonded with a bottom adhesive layer, and the other side surface of the flexible substrate is adhesively bonded with a surface adhesive layer. Through holes are formed in the fixed adhesive layer, passing through the bottom adhesive layer, the flexible substrate and the surface adhesive layer. The through holes contain the biomass nano-drug layer.

[0007] The bottom adhesive layer includes the following components: SIS hot melt pressure-sensitive adhesive grafted with methyl methacrylate, hyaluronic acid silicone gel, nanoaluminum magnesium silicate;

[0008] The surface adhesive layer includes the following components: benzophenone photoinitiator, SIS hot melt pressure-sensitive adhesive grafted with acrylic acid, nano-titanium dioxide, quaternary ammonium salt modified chitosan, N,N'-methylenebisacrylamide;

[0009] The movable adhesive layer includes a hydrogel drug carrier. The biomass nano-drug layer is adsorbed on the hydrogel drug carrier. The hydrogel drug carrier is adhesively bonded to the surface adhesive layer of the fixed adhesive layer.

[0010] Among them, the peel strength between the primer layer and the adhered substrate is greater than the peel strength between the topcoat layer and the active adhesive layer.

[0011] Based on the biomass nano-drug layer, the present invention mainly improves the adhesive layer. By utilizing the different peel strengths between the adhesive layers, a split-type rhinitis patch can be obtained. When replacing the drug, only the active adhesive layer needs to be replaced, and the fixed adhesive layer adhered to the skin remains stationary. When frequently replacing the drug layer, the skin will not be repeatedly pulled, reducing the risk of skin damage.

[0012] The pressure-sensitive adhesive is a commonly used colloid in the field of dressings such as nasal patches. The present invention has been improved on the basis of the pressure-sensitive adhesive.

[0013] The principle of the present invention is as follows: The fixed adhesive layer of the present invention uses a flexible substrate (non-woven fabric) as the substrate, and two different adhesive layers are provided on its two sides, namely the topcoat layer and the primer layer. The peel strength of the primer layer is greater than that of the topcoat layer. The primer layer adheres to the skin, the topcoat layer adheres to the active adhesive layer, and the active adhesive layer is used to support the biomass nano-drug layer. By improving the components of each adhesive layer, the adhesive strength between the active adhesive layer and the topcoat layer < the adhesive strength between the primer layer and the skin < the adhesive strength between the topcoat layer and the primer layer. Within this peel strength relationship, when replacing the drug layer, the old active adhesive layer is torn off the fixed adhesive layer as a whole, the fixed adhesive layer remains on the skin, and then the new active adhesive layer containing the new drug layer is adhered to the fixed adhesive layer, thus completing the replacement of the dressing drug without repeatedly pulling the skin.

[0014] In order to prevent the separation between the topcoat layer and the primer layer, the present invention adopts a photoinitiator, SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate, and SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid. Under the action of light and the photoinitiator, methyl methacrylate and acrylic acid will polymerize to enhance the adhesion strength between the topcoat layer and the primer layer. The flexible substrate has good air permeability and porosity. Before the topcoat layer and the primer layer are cured, the two will penetrate through the flexible substrate and fuse with each other. Under the action of the initiator and the crosslinking agent, the two will undergo a chemical reaction to form a chemical bond connection, with a relatively strong connection strength and not easily separated. In the above formula of the present invention, the primer layer can also be peeled off from the skin, which is convenient to tear off the primer layer from the skin without hurting the skin.

[0015] In the present invention, the hyaluronic acid silicone gel has the functions of moisturizing, nourishing, and repairing damaged skin, and can relieve the discomfort of the primer layer adhering to the skin.

[0016] In the present invention, nano-aluminum magnesium silicate will swell into a colloid after absorbing water, which can reduce the influence of sweat on the skin on the adhesion of the primer layer.

[0017] In the present invention, since the base adhesive layer needs to be in direct contact with the skin, while ensuring its strong peel strength, it is also necessary to reduce the impact of the base adhesive layer on the skin. Therefore, hyaluronic acid silicone gel is added to the present invention. During actual use, there is likely to be sweat on the skin, and the sweat will reduce the adhesiveness of the base adhesive layer. Therefore, nanoaluminum magnesium silicate is added to the base adhesive layer. During the addition of nanoaluminum magnesium silicate, the good compatibility and dispersibility between nanoaluminum magnesium silicate and other components of the base adhesive layer are mainly considered.

[0018] Further, the addition amount of benzophenone photoinitiator in the surface adhesive layer is 1-3% of the total mass of SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid and SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate. The mass ratio of SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid to chitosan grafted with quaternary ammonium salt is 6-7:1. The addition amount of nano-titanium dioxide is 1.4-1.5% of the mass of SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid. The addition amount of N,N'-methylenebisacrylamide is 0.5-1% of the total mass of SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid and SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate.

[0019] Further, the mass ratio of SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate to hyaluronic acid silicone gel in the base adhesive layer is 4:1. The addition amount of nanoaluminum magnesium silicate is 2-3% of the mass of SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate.

[0020] Further, the movable adhesive layer further includes a flexible substrate. One side surface of the hydrogel drug carrier is adhered to one side surface of the flexible substrate through an adhesive. A biomaterial nano-drug layer is adsorbed on the other side surface of the hydrogel drug carrier.

[0021] The adhesive includes the following components in parts by weight: carrageenan, carboxymethyl chitosan, ethyl sulfamate gum, glutaraldehyde. The mass ratio of carrageenan, carboxymethyl chitosan, and ethyl sulfamate gum is 1:2:0.3. The addition amount of glutaraldehyde is 0.5% of the mass of carboxymethyl chitosan.

[0022] Among them, the peel strength between the hydrogel drug carrier and the flexible substrate is greater than the peel strength between the base adhesive layer and the substrate to which it is adhered.

[0023] In the present invention, the hydrogel drug carrier can be firmly bonded to the flexible substrate through the adhesive, and the hydrogel drug carrier is not easy to fall off, ensuring the integrity of the movable adhesive layer; the hydrogel drug carrier in the present invention is the hydrogel layer, and the drug layer is adhered to the hydrogel layer. The hydrogel and the surface adhesive layer can be bonded together and are easy to peel off, and there will be no residual adhesive after peeling. The flexible substrate in the present invention is generally non-woven fabric. The designed adhesive in the present invention has good compatibility with the hydrogel and the non-woven fabric, and thus strengthens the adhesion between the hydrogel and the non-woven fabric as a bridge, ensuring that the non-woven fabric and the hydrogel do not separate when the movable adhesive layer is torn off; the non-woven fabric provides a supporting role for the hydrogel layer.

[0024] Further, the biomass nano drug layer is composed of biomass carbon nano microspheres; the following substances are adsorbed in the nano pores of the biomass carbon nano microspheres: menthol, borneol, honeysuckle extract, and xanthium sibiricum extract.

[0025] Further, the hydrogel drug carrier adsorbed with the biomass nano drug layer is prepared by the following method: gelatin is added to water, stirred and heated until the gelatin is dissolved, then cooled and the pH is adjusted to 6-7, and then a sodium alginate solution and a polyvinyl alcohol solution are added. After continuing to stir for 10 minutes, a calcium chloride solution and the biomass nano drug are added, and after reacting for 30-40 minutes, the hydrogel drug carrier is obtained by post-curing, and the biomass nano drug forms a biomass nano drug layer on the hydrogel drug carrier; wherein, the mass ratio of gelatin, sodium alginate, and polyvinyl alcohol is 2:1:1, and the addition amount of calcium chloride is 0.5%-0.6% of the mass of sodium alginate.

[0026] Further, the sodium alginate is a low molecular weight sodium alginate with a molecular weight in the range of 2000-3000.

[0027] Further, the flexible substrate is a non-woven fabric impregnated with a silane coupling agent.

[0028] The preparation method of a biomass nano composite for relieving rhinitis includes the following steps:

[0029] S1. Prepare the fixed adhesive layer:

[0030] S1.1. Obtain the flexible substrate: Use a non-woven fabric impregnated with a silane coupling agent as the flexible substrate;

[0031] S1.2. Prepare the bottom adhesive layer: Modify the SIS hot melt pressure-sensitive adhesive with methyl methacrylate to obtain a methyl methacrylate graft-modified SIS hot melt pressure-sensitive adhesive. Add hyaluronic acid silicone gel to the methyl methacrylate graft-modified SIS hot melt pressure-sensitive adhesive, continuously stir for 1 hour, then add magnesium aluminum silicate particles, and stir for 30-40 minutes to obtain the bottom adhesive. Coat the bottom adhesive evenly on one side of the flexible substrate to obtain the bottom adhesive layer;

[0032] S1.3, prepare the surface adhesive layer: modify the SIS hot melt pressure sensitive adhesive with acrylic acid to obtain an acrylic acid grafted modified SIS hot melt pressure sensitive adhesive; add the quaternary ammonium salt modified chitosan solution to the acrylic acid grafted modified SIS hot melt pressure sensitive adhesive at 50°C, stir and mix, then add N,N'-methylenebisacrylamide, continue to react for 1 hour under stirring, then add benzophenone photoinitiator and nano titanium dioxide, mix well, and obtain the surface adhesive, and evenly coat the surface adhesive on the other side of the flexible substrate coated with the base adhesive layer in S1.2 to form a surface adhesive layer, the surface adhesive layer and the base adhesive layer are respectively located on both sides of the flexible substrate;

[0033] S1.4, using ultraviolet light to treat the flexible substrate coated with the surface adhesive layer and the bottom adhesive layer, irradiating with ultraviolet light for 2-3 minutes, and finally curing to obtain a fixed adhesive layer;

[0034] S2. preparing an active adhesive layer: using a non-woven fabric impregnated with a silane coupling agent as a flexible substrate, and adhering a hydrogel drug carrier adsorbed with biomass nano-drugs to one side of the flexible substrate through an adhesive to obtain an active adhesive layer;

[0035] S3, preparing a dressing: pressing and bonding the hydrogel drug carrier and the surface adhesive layer of the fixed adhesive layer, wherein the through holes of the fixed adhesive layer contain biomass nano-drugs; the active adhesive layer and the fixed adhesive layer are combined to form a dressing;

[0036] S4. Packaging: The base adhesive layer of the dressing is protected by release paper and then sealed and packaged to obtain a biomass nanocomposite for relieving rhinitis.

[0037] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0038] 1. The biomass nanocomposite for relieving rhinitis of the present invention utilizes the difference between the bonding strength between the active adhesive layer and the fixed adhesive layer and the bonding strength between the fixed adhesive layer and the skin, so that when the medicine is frequently changed, only the active adhesive layer on the surface of the fixed adhesive layer needs to be replaced, and the entire dressing structure does not need to be replaced, which effectively prevents the skin from being damaged by repeated pulling of the adhesive layer;

[0039] 2. The biomass nanocomposite for relieving rhinitis of the present invention uses biomass carbon nanospheres as the main structure, which realizes the sustained release of drugs and avoids the rapid failure of volatile drugs. The slower the drug failure rate, the longer the use time, which reduces the frequency of replacing the drug layer.

[0040] 3. The present invention uses a flexible substrate, mainly a non-woven fabric, as a supporting structure, and cooperates with a flexible adhesive layer to make the entire drug layer and adhesive layer composite have good flexibility. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as limiting the scope. For those of ordinary skill in the art, without creative efforts, other related drawings can also be obtained based on these drawings, where:

[0042] Figure 1 is a schematic diagram of the fixed adhesive layer structure of the present invention;

[0043] Figure 2 is a schematic diagram of the movable adhesive layer structure of the present invention;

[0044] Reference numerals in the figure: 1 - fixed adhesive layer, 11 - through hole, 2 - movable adhesive layer, 21 - biomass nano-drug layer. Detailed implementation manners

[0045] In order to make the objectives, technical solutions and advantages of the present invention more clear and understandable, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention, that is, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Usually, the components of the embodiments of the present invention described and shown in the accompanying drawings here can be arranged and designed in various different configurations.

[0046] Therefore, the detailed description of the embodiments of the present invention provided in the accompanying drawings below is not intended to limit the scope of the claimed present invention, but only represents the selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present invention.

[0047] It should be noted that relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprising", "including" or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "including one..." does not exclude the existence of additional identical elements in the process, method, article or device including the said element.

[0048] The features and performance of the present invention will be further described in detail below in conjunction with the embodiments.

[0049] Example 1

[0050] As Figure 1 、 Figure 2 shown, a biomass nanocomposite for relieving rhinitis provided by a preferred embodiment of the present invention includes a dressing containing a biomass nano-drug layer. The dressing includes a fixed adhesive layer 1 and a movable adhesive layer 2 that are adhesively bonded to each other. A biomass nano-drug layer 21 is adsorbed on the movable adhesive layer 2. A through-hole 11 is formed in the fixed adhesive layer 1 and passes through the bottom adhesive layer, the flexible substrate, and the surface adhesive layer. When the movable adhesive layer 2 is adhesively bonded to the fixed adhesive layer 1, the biomass nano-drug layer 21 is contained in the through-hole 11. The biomass nano-drug layer 21 in the through-hole 11 can contact the skin under pressing and pasting. After the drug in the biomass nano-drug layer volatilizes, it is inhaled, which helps to relieve the discomfort of rhinitis;

[0051] The fixed adhesive layer 1 includes a flexible substrate, which is a non-woven fabric impregnated with a silane coupling agent. One side of the flexible substrate is adhesively bonded with a bottom adhesive layer, and the other side of the flexible substrate is adhesively bonded with a surface adhesive layer. The bottom adhesive layer of the fixed adhesive layer 1 is bonded to the skin, and the surface adhesive layer of the fixed adhesive layer 1 is adhesively bonded to the movable adhesive layer 2 and the surface adhesive layer of the fixed adhesive layer 1 is peelable from the movable adhesive layer 2;

[0052] The bottom adhesive layer of the fixed adhesive layer 1 includes the following components: SIS hot melt pressure-sensitive adhesive grafted with methyl methacrylate, hyaluronic acid silicone gel, and nano-aluminum magnesium silicate particles. The mass ratio of the SIS hot melt pressure-sensitive adhesive grafted with methyl methacrylate to the hyaluronic acid silicone gel is 4:1, and the addition amount of the nano-aluminum magnesium silicate particles is 2-3% of the mass of the SIS hot melt pressure-sensitive adhesive grafted with methyl methacrylate;

[0053] The surface adhesive layer of the fixed adhesive layer 1 includes the following components: benzophenone photoinitiator, SIS hot melt pressure-sensitive adhesive grafted with acrylic acid, nano-titanium dioxide, quaternary ammonium salt-modified chitosan, and N,N'-methylenebisacrylamide. The addition amount of the benzophenone photoinitiator is 1% of the total mass of the SIS hot melt pressure-sensitive adhesive grafted with acrylic acid and the SIS hot melt pressure-sensitive adhesive grafted with methyl methacrylate. The mass ratio of the SIS hot melt pressure-sensitive adhesive grafted with acrylic acid to the quaternary ammonium salt-modified chitosan is 6-7:1. The addition amount of the nano-titanium dioxide is 1.4-1.5% of the mass of the SIS hot melt pressure-sensitive adhesive grafted with acrylic acid. The addition amount of the N,N'-methylenebisacrylamide is 0.5% of the total mass of the SIS hot melt pressure-sensitive adhesive grafted with acrylic acid and the SIS hot melt pressure-sensitive adhesive grafted with methyl methacrylate.

[0054] The active adhesive layer 2 includes a flexible substrate and a hydrogel drug carrier. The flexible substrate is a non-woven fabric impregnated with a silane coupling agent. One side surface of the hydrogel drug carrier is adhered to one side surface of the flexible substrate through an adhesive; on the other side surface of the hydrogel drug carrier, a biomass nano-drug layer 21 is adsorbed, and the biomass nano-drug layer 21 is composed of biomass carbon nano-microspheres; adsorbed in the nano-pores on the biomass carbon nano-microspheres are the following substances: menthol, borneol, honeysuckle extract, and xanthium sibiricum extract;

[0055] The adhesive between the hydrogel drug carrier and the non-woven fabric includes the following components in parts by weight: carrageenan, carboxymethyl chitosan, ethyl sulfamate gum, and glutaraldehyde. The mass ratio of carrageenan, carboxymethyl chitosan, and ethyl sulfamate gum is 1:2:0.3, and the addition amount of glutaraldehyde is 0.5% of the mass of carboxymethyl chitosan; the adhesive is prepared by the following method: uniformly mix the carrageenan solution and the ethyl sulfamate gum solution, then add the carboxymethyl chitosan solution, stir evenly, heat up to 50 °C, add glutaraldehyde, stir evenly, react for 1.5 hours, and cool to room temperature to obtain the adhesive.

[0056] The hydrogel drug carrier adsorbed with the biomass nano-drug layer is prepared by the following method: add gelatin to water at 60 °C, stir until the gelatin is dissolved, then cool to 40 °C to obtain a gelatin solution, adjust the pH to 6-7, then add a sodium alginate solution and a polyvinyl alcohol solution, continue to stir for 10 minutes, then add a calcium chloride solution and the biomass nano-drug, react for 30-40 minutes to obtain a hydrogel, and after solidifying and forming, obtain the hydrogel drug carrier adsorbed with the biomass nano-drug layer; wherein, the mass ratio of gelatin, sodium alginate, and polyvinyl alcohol is 2:1:1, and the addition amount of calcium chloride is 0.5%-0.6% of the mass of sodium alginate. The sodium alginate is a low-molecular-weight sodium alginate with a molecular weight in the range of 2000-3000.

[0057] The preparation method of a biomass nano-composite for relieving rhinitis includes the following steps:

[0058] S1. Prepare a fixed adhesive layer:

[0059] S1.1. Obtain a flexible substrate: Use a non-woven fabric impregnated with a silane coupling agent as the flexible substrate;

[0060] S1.2. Preparation of the base glue layer: While stirring, a mixed solution of methyl methacrylate and BPO initiator is dropped into the molten SIS hot-melt pressure-sensitive adhesive. The mass ratio of methyl methacrylate to BPO initiator in the mixed solution is 15:1, and the addition amount of methyl methacrylate is 7-8% of the mass of the SIS hot-melt pressure-sensitive adhesive. After reacting at 80 °C for 3 hours, BPO initiator is continuously added. At this time, the addition amount of BPO initiator is half of the first addition amount of BPO initiator. After stirring evenly, the reaction continues for 1 hour. Then, the temperature is lowered to 50 °C, and terpene resin is added. After stirring evenly, the SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate is obtained. Then, hyaluronic acid silicone gel is added to the SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate. After continuously stirring for 1 hour, the temperature is lowered to 40 °C, and nanoaluminum magnesium silicate particles are added. After stirring for 30-40 minutes, the base glue is obtained. The base glue is evenly coated on one side of the flexible substrate to obtain the base glue layer;

[0061] S1.3. Preparation of the surface glue layer: While stirring, a mixed solution of acrylic acid and BPO initiator is dropped into the molten SIS hot-melt pressure-sensitive adhesive. The mass ratio of acrylic acid to BPO initiator in the mixed solution is 25:1, and the addition amount of acrylic acid is 5% of the mass of the SIS hot-melt pressure-sensitive adhesive. After reacting at 70 °C for 3.5 hours, BPO initiator is continuously added. At this time, the addition amount of BPO initiator is half of the first addition amount of BPO initiator. After stirring evenly, the reaction continues for 1 hour. Then, the temperature is lowered to 50 °C, and terpene resin is added. After stirring evenly, the SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid is obtained; Subsequently, at 50 °C, a quaternary ammonium salt-modified chitosan solution is added to the SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid. After stirring and mixing for 20 minutes, N,N'-methylenebisacrylamide is added. After reacting for 1 hour under stirring, benzophenone photoinitiator and nano-titanium dioxide are added and mixed evenly to obtain the surface glue. The surface glue is evenly coated on the other side of the flexible substrate coated with the base glue layer in S1.2 to form the surface glue layer. The surface glue layer and the base glue layer are located on both sides of the flexible substrate respectively;

[0062] S1.4. The flexible substrate coated with the surface glue layer and the base glue layer is subjected to light treatment with ultraviolet light for 2-3 minutes, and finally cured and formed to obtain the fixed glue layer;

[0063] S2. Preparation of the movable glue layer: A non-woven fabric impregnated with a silane coupling agent is used as the flexible substrate, and the hydrogel drug carrier adsorbed with the biological nano-drug is adhered to one side of the flexible substrate through an adhesive to obtain the movable glue layer;

[0064] S3. Preparation of the dressing: The hydrogel drug carrier is pressed and adhered to the surface glue layer of the fixed glue layer. There is a biological nano-drug in the through-hole of the fixed glue layer; The movable glue layer and the fixed glue layer are combined to form the dressing;

[0065] S4. Packaging: After protecting the base adhesive layer of the dressing with release paper, it is sealed and packaged to obtain a biomass nanocomposite for relieving rhinitis.

[0066] Example 2

[0067] Based on Example 1, the difference in this example from Example 1 is that the addition amount of benzophenone photoinitiator in the surface adhesive layer is 2% of the total mass of the SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid and the SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate.

[0068] Example 3

[0069] Based on Example 1, the difference in this example from Example 1 is that the addition amount of benzophenone photoinitiator in the surface adhesive layer is 3% of the total mass of the SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid and the SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate.

[0070] Example 4

[0071] Based on Example 2, the difference in this example from Example 2 is that the addition amount of N,N'-methylenebisacrylamide is 0.8% of the total mass of the SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid and the SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate. The pharmacodynamic time of the biomass nano-drug layer of the present invention can last for more than 12 hours.

[0072] Example 5

[0073] Based on Example 2, the difference in this example from Example 2 is that the addition amount of N,N'-methylenebisacrylamide is 1% of the total mass of the SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid and the SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate.

[0074] Comparative Example 1

[0075] Based on Example 4, the difference in this comparative example from Example 2 is that the mass ratio of the SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid to the chitosan modified with quaternary ammonium salt in the surface adhesive layer of this comparative example is 5:1.

[0076] Comparative Example 2

[0077] Based on Example 4, the difference in this comparative example from Example 4 is that the mass ratio of the SIS hot-melt pressure-sensitive adhesive grafted with acrylic acid to the chitosan modified with quaternary ammonium salt in the surface adhesive layer of this comparative example is 8:1.

[0078] Comparative Example 3

[0079] On the basis of Example 4, this comparative example is different from Example 4 in that: the hot melt pressure-sensitive adhesive in the surface adhesive layer of this comparative example is an ungrafted SIS hot melt pressure-sensitive adhesive; the hot melt pressure-sensitive adhesive in the primer layer is also an ungrafted SIS hot melt pressure-sensitive adhesive; the surface adhesive layer does not contain benzophenone photoinitiator; ultraviolet light is not used to perform light treatment on the flexible substrate coated with the surface adhesive layer and the primer layer.

[0080] Comparative Example 4

[0081] On the basis of Example 4, this comparative example is different from Example 4 in that: the surface adhesive layer of this comparative example does not contain benzophenone photoinitiator; ultraviolet light is not used to perform light treatment on the flexible substrate coated with the surface adhesive layer and the primer layer.

[0082] Comparative Example 5

[0083] On the basis of Example 4, this comparative example is different from Example 4 in that: this comparative example does not contain a surface adhesive layer and an intermediate flexible substrate, and the active adhesive layer is directly bonded to the surface of the primer layer. The peel strength between the active adhesive layer and the primer layer is much greater than the peel strength between the active adhesive layer and the surface adhesive layer. The dressing change speed is slow when the active adhesive layer is directly adhered to the primer layer, and there will be residual adhesive of the active adhesive layer on the primer layer.

[0084] Comparative Example 6

[0085] On the basis of Example 4, this comparative example is different from Example 4 in that: this comparative example does not contain a primer layer and an intermediate flexible substrate, and the active adhesive layer is directly bonded to the surface of the surface adhesive layer. The peel strength between the active adhesive layer and the surface adhesive layer is basically the same as the peel strength of the surface adhesive layer on the skin. Compared with the primer layer, the adhesiveness of the surface adhesive layer is weak, and it is easy to tear off the surface adhesive layer during the process of tearing off the active adhesive layer. In the present invention, the adhesiveness of the primer layer is greater than that of the surface adhesive layer.

[0086] Comparative Example 7

[0087] On the basis of Example 4, this comparative example is different from Example 4 in that: the primer layer of this comparative example does not contain nanoaluminum magnesium silicate particles.

[0088] Test Example 1

[0089] Detect the 180-degree peel strength Q1 between the active adhesive layer and the surface adhesive layer, the 180-degree peel strength Q2 between the surface adhesive layer and the primer layer, and the peel strength Q3 of the primer layer in Examples 1-5 and Comparative Examples 1-4; the detection results are shown in Table 1.

[0090] The detection method for the 180-degree peel strength between the active adhesive layer and the surface adhesive layer and the detection method for the 180-degree peel strength between the surface adhesive layer and the primer layer both adopt the existing interlayer 180-degree peel strength detection method;

[0091] The peel strength Q3 of the primer layer is detected according to the peel strength test method in the medical industry standard YY / T 0148-2006 "General Requirements for Medical Adhesives": Measure the force required to peel the adhesive layer from the steel plate (the application angle is 180 degrees, and the peel speed is 270 mm / min to 330 mm / min).

[0092] Table 1 Peel Strengths of Each Adhesive Layer

[0093] Peeling strength Q1 Peeling strength Q2 Peeling strength Q3 Example 1 1.2 - 1.3 N / cm 6.2 - 6.3 N / cm 3.2 - 3.4 N / cm Example 2 1.4 - 1.5 N / cm 6.4 - 6.5 N / cm 3.5 - 3.6 N / cm Example 3 1.0 - 1.1 N / cm 6.0 - 6.1 N / cm 3.2 - 3.4 N / cm Example 4 1.4 - 1.5 N / cm 6.6 - 6.7 N / cm 3.6 - 3.7 N / cm Example 5 1.4 - 1.6 N / cm 6.8 - 6.9 N / cm 3.9 - 4.0 N / cm Comparative Example 1 3.2 - 3.3 N / cm 7.3 - 7.4 N / cm 3.6 - 3.7 N / cm Comparative Example 2 0.5 - 0.7 N / cm 4.8 - 5.1 N / cm 3.6 - 3.7 N / cm Comparative Example 3 1.2 - 1.3 N / cm 1.2 - 1.3 N / cm 1.8 - 2.0 N / cm Comparative Example 4 1.2 - 1.3 N / cm 2.4 2.5 / cm 2.5 - 2.8 N / cm

[0094] After the active adhesive layer and the top adhesive layer are separated in Examples 1-5 of the present invention, there is no residual adhesive of the active adhesive layer on the top adhesive layer, and the peel speed is fast. Without external force peeling, the active adhesive layer will not easily separate from the top adhesive layer; when peeling the active adhesive layer in the present invention, the top adhesive layer and the primer layer will not separate, and the primer layer and the pasting substrate will not separate either. In the present invention, within this peel strength range, the primer layer has both a certain use adhesiveness and is easy to peel, and there is no residual adhesive left after peeling, and the harm to the skin can be ignored.

[0095] In Comparative Example 1, when the proportion of quaternary ammonium salt-modified chitosan in the top adhesive layer relative to the acrylic graft-modified SIS hot melt pressure-sensitive adhesive increases, the peel strength between the active adhesive layer and the top adhesive layer will increase significantly, and the adhesiveness of the two will increase, which will slow down the speed of tearing the active adhesive layer from the top adhesive layer, thereby affecting the dressing change efficiency; in addition, after the active adhesive layer and the top adhesive layer are separated in Comparative Example 1, there is residual adhesive of the active adhesive layer on the top adhesive layer.

[0096] In Comparative Example 2, when the proportion of quaternary ammonium salt-modified chitosan in the top adhesive layer relative to the acrylic graft-modified SIS hot melt pressure-sensitive adhesive decreases, the adhesiveness between the active adhesive layer and the top adhesive layer is insufficient, and the active adhesive layer is easy to fall off.

[0097] In Comparative Example 3, during the process of tearing the active adhesive layer, a separation phenomenon occurred between the top adhesive layer and the flexible substrate.

[0098] Test Example 2

[0099] Detect the peel strength of the primer layer in Examples 1-5 and Comparative Example 7 on a stainless steel plate containing sweat;

[0100] The detection method is as follows: Press and adhere the primer layer on a stainless steel plate with a sweat sample dropped on the surface, and use a peel testing machine to measure the peel strength of the primer layer, denoted as Q4; Measuring the peel strength of the primer layer with a peel testing machine is the prior art. The test results are shown in Table 2.

[0101] Table 2 Peel Strengths of the Primer Layer

[0102] Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 7 Peeling strength Q4 3.0 - 3.1 N / cm 3.3 - 3.4 N / cm 3.1 - 3.2 N / cm 3.5 - 3.6 N / cm 3.7 - 3.8 N / cm < 1 N / cm

[0103] In the present invention, magnesium aluminum silicate reduces the degree of reduction in adhesiveness of the base adhesive layer after being infiltrated by sweat, and the base adhesive layer still has high adhesiveness, without any situation of partial detachment from the skin. Example 4 of the present invention is the optimal solution.

[0104] The above are only the preferred embodiments of the present invention, and are not intended to limit the protection scope of the present invention. Any modifications, equivalent substitutions, and improvements made by those skilled in the art within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A biomass nanocomposite for relieving rhinitis, comprising a dressing containing a biomass nanomedicine layer, characterized in that: The dressing comprises a fixed adhesive layer (1) and a movable adhesive layer (2) which are bonded to each other, and a biomass nano drug layer (21) is adsorbed on the movable adhesive layer (2); the fixed adhesive layer (1) comprises a flexible substrate, a bottom adhesive layer is bonded to one side of the flexible substrate, and a surface adhesive layer is bonded to the other side of the flexible substrate, and a through hole (11) is provided on the fixed adhesive layer (1) which passes through the bottom adhesive layer, the flexible substrate and the surface adhesive layer, and the biomass nano drug layer (21) is contained in the through hole (11); The base adhesive layer comprises the following components: SIS hot-melt pressure-sensitive adhesive grafted with methyl methacrylate, hyaluronic acid silicone gel, and nano-magnesium aluminum silicate; The surface adhesive layer comprises the following components: benzophenone photoinitiator, acrylic acid grafted modified SIS hot melt pressure sensitive adhesive, nano titanium dioxide, quaternary ammonium salt modified chitosan, N,N'-methylenebisacrylamide; The movable adhesive layer (2) comprises a hydrogel drug carrier, the biomass nano drug layer (21) is adsorbed on the hydrogel drug carrier, and the hydrogel drug carrier is bonded to the surface adhesive layer of the fixed adhesive layer (1).

2. The biomass nanocomposite for relieving rhinitis according to claim 1, characterized in that: The amount of benzophenone photoinitiator added in the surface adhesive layer is 1-3% of the total mass of the SIS hot melt pressure-sensitive adhesive grafted with acrylic acid and the SIS hot melt pressure-sensitive adhesive grafted with methyl methacrylate, the mass ratio of the SIS hot melt pressure-sensitive adhesive grafted with acrylic acid to the quaternary ammonium salt modified chitosan is 6-7:1, the amount of nano titanium dioxide added is 1.4-1.5% of the mass of the SIS hot melt pressure-sensitive adhesive grafted with acrylic acid, and the amount of N,N'-methylenebisacrylamide added is 0.5-1% of the total mass of the SIS hot melt pressure-sensitive adhesive grafted with acrylic acid and the SIS hot melt pressure-sensitive adhesive grafted with methyl methacrylate.

3. The biomass nanocomposite for relieving rhinitis according to claim 2, characterized in that: The mass ratio of the SIS hot melt pressure sensitive adhesive modified by grafting of methyl methacrylate to the hyaluronic acid silicone gel in the base adhesive layer is 4:1, and the amount of nano-magnesium aluminum silicate added is 2-3% of the mass of the SIS hot melt pressure sensitive adhesive modified by grafting of methyl methacrylate.

4. The biomass nanocomposite for relieving rhinitis according to claim 1, characterized in that: The movable adhesive layer (2) also includes a flexible substrate, one side surface of the hydrogel drug carrier is adhered to one side surface of the flexible substrate by an adhesive, and the other side surface of the hydrogel drug carrier is adsorbed with a biomass nano drug layer (21); The adhesive comprises the following components in parts by weight: carrageenan, carboxymethyl chitosan, ethyl aminosulfonate gum, and glutaraldehyde, wherein the mass ratio of carrageenan, carboxymethyl chitosan, and ethyl aminosulfonate gum is 1:2:0.3, and the amount of glutaraldehyde added is 0.5% of the mass of carboxymethyl chitosan; The peeling strength between the hydrogel drug carrier and the flexible substrate is greater than the peeling strength between the primer layer and the substrate to which it is bonded.

5. The biomass nanocomposite for relieving rhinitis according to claim 1, characterized in that: The biomass nano drug layer (21) is composed of biomass carbon nano microspheres; the following substances are adsorbed in the nanopores on the biomass carbon nano microspheres: menthol, borneol, honeysuckle extract, and Xanthium sibiricum extract.

6. The biomass nanocomposite for relieving rhinitis according to claim 4, characterized in that: The hydrogel drug carrier adsorbed with a biomass nano drug layer (21) is prepared by the following method: adding gelatin to water, stirring and heating until the gelatin is dissolved, cooling and adjusting the pH to 6-7, then adding a sodium alginate solution and a polyvinyl alcohol solution, continuing to stir for 10 minutes, then adding a calcium chloride solution and a biomass nano drug, reacting for 30-40 minutes to obtain a hydrogel drug carrier, and then solidifying the biomass nano drug to form a biomass nano drug layer (21) on the hydrogel drug carrier; wherein the mass ratio of gelatin, sodium alginate and polyvinyl alcohol is 2:1:1, and the amount of calcium chloride added is 0.5%-0.6% of the mass of the sodium alginate.

7. The biomass nanocomposite for relieving rhinitis according to claim 6, characterized in that: The sodium alginate is a low molecular weight sodium alginate with a molecular weight in the range of 2000-3000.

8. The biomass nanocomposite for relieving rhinitis according to claim 1 or 4, characterized in that: The flexible substrate is a non-woven fabric impregnated with a silane coupling agent.

9. A method for preparing a biomass nanocomposite for relieving rhinitis according to any one of claims 1 to 7, characterized in that: The following steps are involved: S1. Preparation of fixed adhesive layer: S1.

1. Obtaining a flexible substrate: using a non-woven fabric impregnated with a silane coupling agent as a flexible substrate; S1.2, preparing a primer layer: modifying SIS hot melt pressure sensitive adhesive with methyl methacrylate to obtain SIS hot melt pressure sensitive adhesive grafted with methyl methacrylate, adding hyaluronic acid silicone gel to the SIS hot melt pressure sensitive adhesive grafted with methyl methacrylate, adding aluminum magnesium silicate particles after continuous stirring for 1 hour, stirring for 30-40 minutes to obtain a primer, and evenly coating the primer on one side of the flexible substrate to obtain a primer layer; S1.3, prepare the surface adhesive layer: modify the SIS hot melt pressure sensitive adhesive with acrylic acid to obtain an acrylic acid grafted modified SIS hot melt pressure sensitive adhesive; add the quaternary ammonium salt modified chitosan solution to the acrylic acid grafted modified SIS hot melt pressure sensitive adhesive at 50°C, stir and mix, then add N,N'-methylenebisacrylamide, continue to react for 1 hour under stirring, then add benzophenone photoinitiator and nano titanium dioxide, mix well, and obtain the surface adhesive, and evenly coat the surface adhesive on the other side of the flexible substrate coated with the base adhesive layer in S1.2 to form a surface adhesive layer, the surface adhesive layer and the base adhesive layer are respectively located on both sides of the flexible substrate; S1.4, using ultraviolet light to treat the flexible substrate coated with the surface adhesive layer and the bottom adhesive layer, irradiating with ultraviolet light for 2-3 minutes, and finally curing to obtain a fixed adhesive layer; S2. preparing an active adhesive layer: using a non-woven fabric impregnated with a silane coupling agent as a flexible substrate, and adhering a hydrogel drug carrier adsorbed with biomass nano-drugs to one side of the flexible substrate through an adhesive to obtain an active adhesive layer; S3, preparing a dressing: pressing and bonding the hydrogel drug carrier and the surface adhesive layer of the fixed adhesive layer, wherein the through holes of the fixed adhesive layer contain biomass nano-drugs; the active adhesive layer and the fixed adhesive layer are combined to form a dressing; S4. Packaging: The base adhesive layer of the dressing is protected by release paper and then sealed and packaged to obtain a biomass nanocomposite for relieving rhinitis.

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