Application of artemisia desertorum to preparation of product for preventing and treating sheep from being infected with sheep nose fly maggot disease

Abstract

The invention provides application of artemisia desertorum to preparation of a product for preventing and treating sheep from being infected with sheep nose fly maggot disease, and belongs to the technical field of medicine. Research finds that artemisia desertorum can effectively kill the sheep-nose fly maggots and promote wound healing caused by the sheep-nose fly maggots. Artemisia desertorum is a natural plant, is widely distributed, is convenient to obtain materials, has an excellent effect of treating sheep nose fly maggot disease, and is beneficial to guarantee of high-quality development of sheep industry.

Description

Technical Field

[0001] The present invention belongs to the field of pharmaceutical technology, and particularly relates to the application of Artemisia desertorum in the preparation of products for preventing and treating sheep from being infected with Oestrus ovis larvae disease. Background Art

[0002] The sheep botfly, also known as Oestrus ovis, has three life stages: larvae, pupae, and adults. The adults fly outside the sheep, chase the sheep, and wait for an opportunity to suddenly rush towards the sheep's nose and urethral orifice on windless days in hot summer, shooting the larvae into the vicinity of the nostrils and urethral orifice. The larvae automatically crawl into the nasal cavity and urethral orifice and parasitize in the nasal cavity, nearby sinus cavities, and deep within the urethral orifice. The parasitism time varies from 1 to 10 months, and the number of parasites ranges from 20 to over 150. After the larvae grow up, they crawl out from the parasitized area or are ejected from the sheep's nose, fall to the ground and turn into pupae. In the soil, it takes about three weeks to two months (varying with temperature). When fully emerged, they break through the pupal shell and fly out as flies.

[0003] When the adult flies of Oestrus ovis attack the sheep flock to lay larvae, it causes restlessness among the sheep flock, with the sheep crowding each other, frequently shaking their heads, snorting, or turning their nostrils towards the ground, seriously disturbing the feeding and rest of the sheep, resulting in poor growth and development of the sheep and gradual emaciation. The larvae parasitize in the sheep's nasal cavity or urethral orifice, making the sheep listless, restless, emaciated or dead; the mouth hooks of the larvae damage the nasal mucosa, causing rhinitis and making the sheep have difficulty breathing; after the larvae parasitize, the sheep frequently sneeze, shake their heads, rub their noses, shed tears, have a reduced appetite, and gradually become emaciated; individual larvae can enter the cranial cavity, causing encephalitis, making the sheep have ataxia, rotation, paralysis, and loss of appetite and die.

[0004] Usually, chemical synthetic drugs such as 3% lysol, doramectin, iodonitrophenol, trichlorfon, or ivermectin are generally used to spray the affected area for treating Oestrus ovis larvae disease in sheep. However, there are various drawbacks when using chemical synthetic drugs to treat Oestrus ovis larvae disease in sheep, such as: the larvae are prone to develop drug resistance; there will be drug residues, which will more or less affect the environment; the drug use cost is high, the operation of preparing the medicine is complex, and it is very inconvenient to purchase drugs in remote grazing pastures; the production of high-quality organic mutton requires little or no use of chemical veterinary drugs. To ensure the high-quality development of the sheep industry, there is an urgent need to find green and organic natural veterinary drugs to treat sheep diseases.

[0005] Artemisia desertorum is a perennial herb of the genus Artemisia in the Compositae family. The roots, stems, leaves, and seeds of Artemisia desertorum can all be used as medicine, with the effects of dispelling wind and dampness, clearing heat and reducing swelling, and being used to treat symptoms such as rheumatic arthritis and sore throat. Artemisia desertorum is widely distributed and is convenient to obtain materials. The leaves of Artemisia desertorum are easily available in summer. Currently, there is no relevant report on Artemisia desertorum having the effect of treating Oestrus ovis larvae disease. Summary of the Invention

[0006] In view of this, the purpose of the present invention is to provide the application of Artemisia desertorum in the preparation of products for preventing and treating sheep from being infected with Oestrus ovis larvae disease, so as to give full play to the dual effects of the leaves of Artemisia desertorum in killing insects and promoting the healing of insect injuries.

[0007] To achieve the above-mentioned invention object, the present invention provides the following technical solutions:

[0008] Application of Artemisia desertorum in the preparation of products for preventing and treating sheep from being infected with Oestrus ovis larvae disease.

[0009] Preferably, the Artemisia desertorum kills the Oestrus ovis larvae.

[0010] Preferably, the Artemisia desertorum promotes the healing of wounds caused by Oestrus ovis larvae.

[0011] Preferably, the sheep include goats and sheep.

[0012] Preferably, the Artemisia desertorum is the juice filtered and collected after pounding the leaves of Artemisia desertorum.

[0013] Preferably, the dosage of the Artemisia desertorum is 80 - 120 g / sheep calculated by the mass of the leaves of Artemisia desertorum.

[0014] Preferably, the product includes medicines.

[0015] Preferably, the Artemisia desertorum in the medicine is the only active ingredient or one of the active ingredients.

[0016] Another object of the present invention is to provide a preparation for preventing and treating Oestrus ovis larvae disease in sheep, and the preparation contains Artemisia desertorum.

[0017] Preferably, the Artemisia desertorum is the juice filtered and collected after pounding the leaves of Artemisia desertorum.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] The present invention provides the application of Artemisia desertorum in the preparation of products for preventing and treating sheep from being infected with Oestrus ovis larvae disease. The present invention's research finds that Artemisia desertorum can effectively kill the Oestrus ovis larvae and promote the healing of wounds caused by Oestrus ovis larvae. Artemisia desertorum is a natural plant, widely distributed, convenient to obtain materials, has excellent effects in treating Oestrus ovis larvae disease, and helps to ensure the high-quality development of the sheep industry. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 Prescription form issued for treating Oestrus ovis larvae disease, issue date: August 10, 2023;

[0021] Figure 2 Prescription form issued for treating Oestrus ovis larvae disease, issue date: August 19, 2023;

[0022] Figure 3 Prescription form issued for treating Oestrus ovis larvae disease, issue date: September 11, 2023;

[0023] Figure 4 Prescription form issued for treating Oestrus ovis larvae disease, issue date: July 27, 2024;

[0024] Figure 5 Prescription form issued for the treatment of Oestrus ovis in sheep, issued on August 6, 2024. Detailed implementation method

[0025] The present invention provides the application of Artemisia desertorum in the preparation of products for preventing and treating sheep infected with Oestrus ovis. Artemisia desertorum is a perennial herb of the genus Artemisia in the Compositae family, with the effects of dispelling wind and dampness, clearing heat and reducing swelling. The present invention researches and discovers that Artemisia desertorum can effectively kill Oestrus ovis maggots and promote the healing of wounds caused by Oestrus ovis maggots.

[0026] In the application of the present invention, the sheep include goats and sheep. When using Artemisia desertorum to prevent and treat sheep infected with Oestrus ovis, collect fresh young leaves of Artemisia desertorum, crush the Artemisia desertorum leaves and filter the collected juice, and spray the collected juice on the affected area. The dosage of Artemisia desertorum is 80-120 g / sheep based on the mass of Artemisia desertorum leaves, preferably 100 g / sheep. In the specific embodiments of the present invention, the fresh young leaves of Artemisia desertorum refer to the newly grown, not fully unfolded or just fully unfolded leaves of Artemisia desertorum when it is in the vigorous growth period, and the leaves have no obvious damage caused by pests and diseases, no wilting, drying or yellowing.

[0027] In the present invention, the product for preventing and treating sheep infected with Oestrus ovis includes medicines, and Artemisia desertorum is the only active ingredient or one of the active ingredients in the medicines.

[0028] The present invention also provides a preparation for preventing and treating Oestrus ovis, and the preparation contains Artemisia desertorum, and the Artemisia desertorum is preferably the juice filtered and collected after crushing Artemisia desertorum leaves.

[0029] The following combines examples to elaborate in detail on the technical solutions provided by the present invention, but they cannot be understood as limiting the protection scope of the present invention.

[0030] Example 1

[0031] A preparation for preventing and treating Oestrus ovis and its application.

[0032] Collect 100 g of fresh young leaves of Artemisia desertorum, crush them and filter the collected juice, and spray the juice on the affected area where Oestrus ovis maggots parasitize.

[0033] Example 2

[0034] A preparation for preventing and treating Oestrus ovis and its application, the difference from Example 1 is: collect 80 g of fresh young leaves of Artemisia desertorum.

[0035] Example 3

[0036] A preparation for preventing and treating Oestrus ovis and its application, the difference from Example 1 is: collect 120 g of fresh young leaves of Artemisia desertorum.

[0037] Example 4

[0038] Effect of Artemisia desertorum on killing the larvae of Oestrus ovis

[0039] Twenty larvae of Oestrus ovis were collected from the affected parts of sheep infected with Oestrus ovis larvae and randomly divided into 4 groups, with 5 larvae in each group.

[0040] Group 1: The larvae of Oestrus ovis were placed in the juice collected in Example 1;

[0041] Group 2: The larvae of Oestrus ovis were placed in the juice collected in Example 2;

[0042] Group 3: The larvae of Oestrus ovis were placed in the juice collected in Example 3;

[0043] Group 4: The larvae of Oestrus ovis were placed in clean water, and the amount of clean water was the same as the volume of the juice collected in Example 1.

[0044] After the larvae of Oestrus ovis were placed in different juices (or clean water) for 10 minutes, the viability of the larvae of Oestrus ovis was examined. The examination method was to gently touch the larvae of Oestrus ovis with forceps. If the larvae of Oestrus ovis remained stationary, they were considered inactivated. If the larvae of Oestrus ovis wriggled, they were considered to still have viability.

[0045] It was found that all 5 larvae of Oestrus ovis in Group 4 still had viability, but all the larvae of Oestrus ovis in Groups 1 - 3 lost their viability. This indicates that the doses provided by the present invention can effectively and rapidly inactivate the larvae of Oestrus ovis, and Artemisia desertorum has excellent efficacy in killing the larvae of Oestrus ovis.

[0046] Example 5

[0047] Therapeutic effect of Artemisia desertorum on treating Oestrus ovis disease

[0048] Since 2023, in different pastures, sheep diagnosed with Oestrus ovis disease were treated. The treatment method was to use the preparation of Example 1: 100 g of fresh young leaves of Artemisia desertorum were collected, mashed and filtered to collect the juice, and the juice was sprayed on the affected parts where the larvae of Oestrus ovis parasitized. Each affected sheep was treated once (i.e., the juice of Artemisia desertorum was sprayed on the affected part once).

[0049] The number of recovered sheep was counted on the second day after the treatment ended. The judgment criteria for a sheep to recover were: no larvae of Oestrus ovis were found in the affected part; the affected sheep behaved quietly and ate normally.

[0050] The treatment effects in 2023 are shown in Table 1, and the treatment effects in 2024 are shown in Table 2. Figures 1 to 5 Some prescription slips issued for treating Oestrus ovis disease

[0051] Table 1 Therapeutic effect data (2023)

[0052]

[0053] Table 2 Efficacy Data (2024)

[0054]

[0055] As can be seen from the results of Table 1 and Table 2, Artemisia desertorum can effectively kill the nasal bot fly maggots of sheep, and has excellent efficacy in treating nasal bot fly disease of sheep.

[0056] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and modifications can be made, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. The application of Artemisia ordosica in the preparation of products for preventing and treating sheep infection with sheep nasal myiasis.

2. The use according to claim 1, characterized in that: The Artemisia sphaerocephala kills sheep nose fly maggots.

3. The use according to claim 1, characterized in that: The Artemisia ordosica promotes the healing of wounds caused by sheep nose fly maggots.

4. The use according to claim 1, characterized in that: The sheep include goats and sheep.

5. The use according to claim 1, characterized in that: The wormwood is juice collected by filtering after crushing wormwood leaves.

6. The use according to claim 1, characterized in that: The dosage of Artemisia ordosica is 80-120 g / sheep based on the weight of Artemisia ordosica leaves.

7. The use according to claim 1, characterized in that: The products include pharmaceutical products.

8. The use according to claim 7, characterized in that: In the medicine, Artemisia ordosica is the only active ingredient or one of the active ingredients.

9. A preparation for preventing and treating sheep nose myiasis, characterized in that: The preparation contains Artemisia ordosica.

10. The preparation according to claim 9, characterized in that The wormwood is juice collected by filtering after crushing wormwood leaves.

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