Traditional Chinese medicine acupoint application preparation for treating thoracic obstruction and preparation method of traditional Chinese medicine acupoint application preparation

Abstract

The invention discloses a traditional Chinese medicine acupoint application preparation for treating thoracic obstruction and a preparation method thereof, and relates to the technical field of traditional Chinese medicine compositions for treating thoracic obstruction, and the traditional Chinese medicine acupoint application preparation is prepared from the following active pharmaceutical ingredients in parts by weight: 15 parts of galangal, 15 parts of corydalis tuber, 15 parts of curcuma zedoary, 5 parts of asarum, 1 part of borneol and the balance of auxiliary materials. The rhizoma corydalis is used for promoting blood circulation to remove blood stasis and promoting qi circulation to relieve pain; the rhizoma curcumae is used for promoting qi circulation, breaking blood, removing food retention and relieving pain to lay the basis of promoting blood circulation, promoting qi circulation and relieving pain. The asarum is warm in nature and pungent in taste, is good in moving, and assists in promoting blood circulation to remove The galangal is good in dispelling cold evil and relieving pain; and borneol is used for strengthening the pain relieving effect and neutralizing the warm property of the prodrug. The five medicines are combined to achieve the effects of promoting blood circulation to remove blood stasis and promoting qi circulation to relieve pain.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions for treating chest impediment, and particularly relates to a traditional Chinese medicine acupoint application preparation for treating chest impediment and a preparation method thereof. Background Art

[0002] Chest impediment is a disease mainly manifested by chest stuffiness and pain, and even chest pain radiating to the back, accompanied by dyspnea and inability to lie flat. Its pathogenesis is generally deficiency in origin and excess in superficiality, with deficiency of qi, blood, yin and yang as the root cause and qi stagnation, blood stasis and phlegm turbidity as the superficial symptoms. Blockage of the heart meridian is the key pathogenesis. Coronary atherosclerotic heart disease (hereinafter referred to as: coronary heart disease) described in modern medicine is its important corresponding disease.

[0003] 1 Coronary heart disease is one of the top killers threatening human health

[0004] Under the impact of population aging and the prevalence of metabolic risk factors, the inflection point of the decline in the incidence and prevalence of coronary heart disease has not yet appeared, and it shows a trend of getting younger. "Report on Cardiovascular Health and Diseases in China 2023" shows that the prevalence of coronary heart disease among residents over 18 years old in China is 758 / 100,000; data from "China Health Statistics Yearbook 2022" show that the mortality rate of coronary heart disease among urban residents in China is 135.08 / 100,000, and that in rural areas is 148.19 / 100,000. Coronary heart disease has become the top killer threatening human health, imposing a heavy burden on the national economy. Stable coronary heart disease includes ischemic cardiomyopathy, chronic stable exertional angina pectoris, and the stable stage of the disease after treatment of acute coronary syndrome, which is an important stage in the rehabilitation treatment of coronary heart disease. Despite the recommended secondary prevention treatment strategies in the guidelines, the risk of adverse cardiovascular events such as death, myocardial infarction, and stroke within 5 years after the onset of stable coronary heart disease is still as high as 35%.

[0005] Chronic stable exertional angina pectoris is manifested as symptoms such as chest pain and chest tightness in patients during physical exertion, seriously affecting the quality of life of patients, and its treatment and management also face many difficult problems. Drug treatment is the cornerstone of patient treatment. However, the adverse reactions are relatively prominent. For example, long-term use of aspirin may lead to complications such as hemorrhagic diseases and peptic ulcers, and taking statin drugs may cause adverse reactions such as abnormal liver function and muscle pain in patients, seriously affecting patient compliance. In addition, there are individual differences in the responses of different patients to drugs. How to accurately select the most suitable drug dose and type for patients remains a major challenge. Coronary revascularization is an effective method for treating coronary heart disease, but its value in improving chronic stable exertional angina pectoris and prognosis is still controversial, and problems such as restenosis after surgery limit the clinical benefits of patients. The treatment mode of integrating traditional Chinese and Western medicine has received increasing attention.

[0006] 2 Acupoint application therapy is an effective method for treating chest impediment

[0007] Paste is one of the five major drug dosage forms in traditional Chinese medicine. It is simple to make and use, convenient, effective and safe. Acupoint patch preparations are improved on the basis of ordinary pastes. They not only have the characteristics of pastes, but also have the advantages of moisturizing, skin affinity and continuous drug penetration. They can show unique therapeutic effects for patients who are unwilling to take medicine and cannot tolerate decoctions.

[0008] The Golden Chamber states that "the pulse should be taken as excessive or insufficient, and the yang is weak and the yin is stringy, which means chest pain". Yang is weak, which means that the yang qi in the upper part of the body is insufficient, and the chest yang is not vigorous. The Plain Questions: Discussion on Pain states that "cold qi enters the meridians and delays, and the pulse does not flow. If it stays outside the pulse, the blood will be insufficient, and if it stays inside the pulse, the qi will not flow, so it will suddenly cause pain". If the chest yang is not vigorous, the yin and cold evil will take advantage of the opportunity to enter, the cold will stagnate, the chest yang will not expand, and the blood will not flow smoothly, which will cause this disease. Therefore, Yanhusuo and Curcuma are given to regulate qi and relieve pain, and to activate blood circulation and promote qi. Yin string means that the yin and cold are too severe, so Gaoliangjiang and Asarum are given to warm the meridians and dispel cold. In addition, borneol is used to lead the various drugs into the heart meridian, and to clear the meridians and relieve pain, and to open the yang and orifices. Modern medical research shows that borneol itself can be absorbed through the skin, and it can also promote the transdermal process of other drugs and enhance the permeability of drugs for acupoint application.

[0009] The "Classic of Acupuncture and Moxibustion" states that "Zhiyang is located below the seventh vertebral segment, where the qi of the Governor Vessel originates. You can take it by bending over." The Governor Vessel is the "sea of ​​the Yang Vessels" and governs the Yang Qi of the whole body. Zhiyang acupoint is a meridian point of the Governor Vessel and is also a key acupoint for treating chest pain. Stimulating Zhiyang acupoint can invigorate the Yang Qi of the Governor Vessel, promote the circulation of Qi and blood in the heart, and unblock the blocked heart vein, thereby relieving symptoms such as chest pain and chest tightness. Modern medical research also shows that stimulating Zhiyang acupoint can quickly relieve the discomfort of patients with chest pain to a certain extent.

[0010] In summary, the purpose of the present invention is to overcome the shortcomings of the current treatment of chest pain, and give full play to the synergistic effect of traditional Chinese medicine and meridians through the continuous action of drugs on Zhiyang acupoints, improve the clinical symptoms of patients, and improve the quality of life. In addition, the present invention has the advantages of "simple, convenient, effective, cheap and safe", and has certain clinical promotion value. Summary of the invention

[0011] The present invention aims to provide a Chinese medicine acupoint application preparation for treating chest pain and a preparation method thereof, so as to maintain the patient's angina pectoris in a stable state, improve the quality of life, and ensure the safety of treatment and the compliance of the patient.

[0012] In order to achieve the above object, the present invention provides the following technical solutions:

[0013] A traditional Chinese medicine acupoint application preparation for treating chest obstruction is provided. The raw materials for making the effective ingredients are, in parts by weight, 15 parts of galangal, 15 parts of yanhusuo, 15 parts of zedoary, 5 parts of asarum, 1 part of borneol, and the rest are auxiliary materials.

[0014] Furthermore, the auxiliary materials are honey and corn oil.

[0015] A preparation method of a traditional Chinese medicine acupoint application preparation for treating chest impediment, comprising the following steps:

[0016] S1. Take galangal, Corydalis yanhusuo, zedoary, asarum and borneol, grind them into medicinal powder, and sieve through a 100-mesh sieve;

[0017] S2. Add honey and corn oil as auxiliary materials to the medicinal powder, and mix the medicinal powder, honey and corn oil according to the prescription ratio of 4.5:6:0.1 to form a dressing;

[0018] S3. Place the dressing into an application patch and apply it to the Zhiyang acupoint.

[0019] Further, in step S3, the application patch includes a 5 cm × 5 cm base film, a 1 cm × 5 cm adhesive layer, a circular drug layer with a diameter of about 3 cm, and a 5 cm × 5 cm waterproof film.

[0020] Principle and beneficial effects of this technical solution:

[0021] Currently, traditional Chinese medicine believes that the main pathological factors of chest impediment are cold coagulation, blood stasis and qi stagnation, and the main pathogenesis is blockage of the heart meridian. Based on this, Corydalis yanhusuo is selected to promote blood circulation to remove blood stasis and promote qi to relieve pain; zedoary is used to promote qi and break blood stasis, eliminate accumulation and relieve pain. The combination of the two drugs lays the foundation for promoting blood circulation, promoting qi and relieving pain in this formula. Asarum is warm in nature and pungent in taste, and is good at walking through the channels, helping to promote blood circulation and dredge collaterals; galangal is good at dispelling cold pathogens and relieving pain; borneol is used as an adjuvant, which can not only strengthen the effect of relieving pain, but also neutralize the warm nature of the previous drugs. The combination of the five drugs together exerts the effects of promoting blood circulation to remove blood stasis and promoting qi to relieve pain. Specific implementation mode

[0022] The following further elaborates on the present invention in conjunction with the implementation mode:

[0023] A traditional Chinese medicine acupoint application preparation for treating chest impediment, the composition of each main raw material medicine is 15 g of galangal, 15 g of Corydalis yanhusuo, 15 g of zedoary, 5 g of asarum, 1 g of borneol, and the rest are auxiliary materials. The auxiliary materials include honey and corn oil. Among them, the five main raw material medicines are ground into powder and mixed with honey and corn oil in a ratio of 4.5:6:0.1 to form a medicinal dressing.

[0024] A preparation method of a traditional Chinese medicine acupoint application preparation for treating chest impediment, comprising the following steps:

[0025] S1. Take galangal, Corydalis yanhusuo, zedoary, asarum and borneol, grind them into medicinal powder, and sieve through a 100-mesh sieve;

[0026] S2. Add honey and corn oil as auxiliary materials to the medicinal powder, and mix the medicinal powder, honey and corn oil according to the prescription ratio of 4.5:6:0.1 to form a dressing;

[0027] S3. Place the dressing into the patch and apply it to the Zhiyang acupoint. The patch includes a 5 cm × 5 cm base film, a 1 cm × 5 cm adhesive layer, a circular drug layer with a diameter of about 3 cm, and a 5 cm × 5 cm waterproof film.

[0028] Clinical Observation Study on the Improvement of Coronary Heart Disease Angina Pectoris by the Present Invention

[0029] 1. Research method: Single-arm clinical study

[0030] 2. Source of cases: Outpatients and inpatients of Xiyuan Hospital, China Academy of Chinese Medical Sciences.

[0031] 3. Inclusion criteria:

[0032] (1) Meeting the diagnostic criteria for stable coronary heart disease;

[0033] (2) Experiencing chest stabbing pain or stuffy pain within the past month, and even spreading to shoulder and back pain;

[0034] (3) Willing to accept the treatment of this study.

[0035] 4. Exclusion criteria

[0036] (1) Having severe skin diseases or being allergic to this product;

[0037] (2) Being unwilling to accept the treatment of this study.

[0038] 5. Experimental drug: 15 g of Alpinia officinarum, 15 g of Corydalis yanhusuo, 15 g of Curcuma zedoaria, 5 g of Asarum sieboldii, and 1 g of Borneol.

[0039] 6. Operation method of acupoint application: The patient takes a sitting position. The operator selects the Zhiyang acupoint, takes out the drug sealed in the plastic ball and places it on the dressing in advance. After cleaning the patient's skin, acupoint application treatment is carried out once a day for 4 - 6 hours each time.

[0040] 7. Observation indicators: Seattle Angina Questionnaire, which is filled out by the patient before acupoint application treatment and 2 weeks after treatment.

[0041] 8. Statistical method: SPSS 25.0 is used for statistical analysis. All measurement data are expressed as mean ± standard deviation. For measurement data that conform to the normal distribution, paired sample T-test is used to compare the data before and after treatment. For measurement data that do not conform to the normal distribution, Wilcoxon signed-rank test is used to compare the data before and after treatment. It is stipulated that P < 0.05 indicates a statistically significant difference.

[0042] 9. Results:

[0043] A total of 46 patients with coronary heart disease were included in this study. The Wilcoxon signed-rank test was used to compare and analyze the scores of the Seattle Angina Questionnaire before and after acupoint application. The results showed that the PL score, AS score, AF score, TS score, and DS score of the patients after treatment were all higher than those before treatment, and the difference was statistically significant (P < 0.05), indicating that after using the chest bi plaster, the degree of physical activity limitation, the stability of angina pectoris, the degree of satisfaction with treatment, and the degree of awareness of the disease in patients were improved, and the attack situation of angina pectoris was controlled.

[0044] Table 1 Comparison of Seattle Angina Questionnaire scores of patients before and after treatment

[0045]

[0046] Note: * indicates P < 0.05 compared with before treatment, and the difference is statistically significant

[0047] The results show that the present invention can effectively improve the degree of physical activity limitation and the stability of angina pectoris in patients with coronary heart disease, reduce the frequency of angina pectoris attacks, improve the quality of life of patients and the degree of satisfaction with disease treatment, and provide a treatment drug with good application prospects for patients with angina pectoris of coronary heart disease.

[0048] The above are only embodiments of the present invention. Specific technical solutions and / or common knowledge such as characteristics well known in the art are not described in detail herein. It should be noted that for those skilled in the art, without departing from the technical solution of the present invention, several non-creative modifications and improvements made should also be regarded as the protection scope of the present invention, and these will not affect the implementation effect of the present invention and the practicality of the patent. The protection scope required by this application shall be subject to the content of its claims, and the specific implementation manners described in the specification can be used to interpret the content of the claims.

Claims

1. A Chinese medicine acupoint application preparation for treating chest pain, characterized in that: The raw materials for making its active ingredients are as follows: 15 parts of galangal, 15 parts of yanhusuo, 15 parts of zedoary, 5 parts of asarum, 1 part of borneol, and the rest are auxiliary materials.

2. A Chinese medicine acupoint application preparation for treating chest pain according to claim 1, characterized in that: The auxiliary materials are honey and corn oil.

3. A method for preparing a Chinese medicine acupoint application preparation for treating chest pain, characterized in that: The steps include: S1. Grind galangal, yanhusuo, zedoaria, asarum and borneol into powder, and pass through a 100-mesh sieve; S2. Add honey and corn oil as auxiliary materials to the medicine powder, and mix the medicine powder, honey and corn oil in a prescription ratio of 4.5:6:0.1 to prepare a dressing; S3. Place the dressing into the patch and stick it on the Zhiyang acupoint.

4. The method for preparing the Chinese medicine acupoint application preparation for treating chest pain according to claim 1, characterized in that: In step S3, the patch includes a 5 cm×5 cm base film, a 1 cm×5 cm adhesive layer, a circular drug layer with a diameter of about 3 cm, and a 5 cm×5 cm waterproof film.

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