An ultra-high-speed jet drug delivery device

Abstract

The present application discloses an ultra-high-speed jet drug delivery device, which relates to the field of drug delivery technology and includes: a jet parameter setting module for determining the direction and speed of the jet according to the drug delivery requirements; a high-energy current module for generating high-energy current to make the metal wire reach a high-temperature state instantly, driving the drug solution to form a high-speed fluid; a nozzle for converting the high-speed fluid into a jet according to the direction and speed of the jet determined by the jet parameter setting module; a sensor module for monitoring the distribution of the drug solution in the body in real time; and a precision delivery module for controlling the jet parameter setting module in real time to adjust the direction and speed of the jet according to the distribution of the drug solution in the body and the drug delivery requirements. In the present application, electric explosion technology is used to form a high-speed jet, providing powerful kinetic energy to effectively penetrate human tissue, achieve precise drug delivery to deep target areas, and combine with sensors to ensure that the drug jet is accurately delivered to deep tissues.

Description

Technical Field

[0001] The present application relates to the technical field of drug delivery, and in particular to an ultra-high-speed jet drug delivery device. Background Art

[0002] Drug delivery is a key research area in modern medicine, directly impacting drug bioavailability, efficacy, and patient experience. Traditional drug delivery methods, such as oral and intravenous injections, while widely used, often suffer from issues such as slow drug absorption, delayed effects, and local irritation. In recent years, needle-free injection technology has garnered attention for its ability to reduce injection pain and improve patient comfort. This technology typically uses springs or high-pressure gas to inject drugs into the skin in the form of fine droplets, but it still lacks sufficient depth and accuracy in drug delivery. Summary of the Invention

[0003] The purpose of this application is to provide an ultra-high-speed jet drug delivery device that can directly and accurately deliver drugs to deep tissues.

[0004] To achieve the above objectives, this application provides the following solutions:

[0005] The present application provides an ultra-high-speed jet drug delivery device, which includes: a jet parameter setting module, a jet generation module, a sensor module, and a precision delivery module;

[0006] The jet parameter setting module is used to determine the direction and speed of the jet according to the drug delivery requirements; the drug delivery requirements include: the location information of the lesion site and the concentration information of the required drug;

[0007] The jet generation module includes: a wire implosion drive unit and a nozzle;

[0008] The wire implosion drive unit includes a high-energy current module and a wire;

[0009] The high-energy current module is used to generate high-energy current to instantly make the metal wire reach a high-temperature state, thereby driving the drug solution to form a high-speed fluid;

[0010] The nozzle is used to convert the high-speed fluid into a jet according to the direction and speed of the jet determined by the jet parameter setting module; the spray angle and diameter of the nozzle are adjustable; adjusting the spray angle of the nozzle can adjust the spray angle of the jet; adjusting the diameter of the nozzle can adjust the spray speed of the jet;

[0011] The sensor module is used to monitor the distribution of the drug solution in the body in real time; the distribution includes: drug concentration and location information;

[0012] The precision delivery module is used to: control the jet parameter setting module in real time to adjust the direction and speed of the jet according to the distribution of the drug solution in the body and the drug delivery requirements.

[0013] According to the specific embodiments provided in this application, this application discloses the following technical effects:

[0014] The present application provides an ultra-high-speed jet drug delivery device, comprising: a jet parameter setting module, a jet generation module, a sensor module, and a precision delivery module; the jet parameter setting module is used to determine the direction and speed of the jet according to the drug delivery requirements; the drug delivery requirements include: the location information of the lesion site and the concentration information of the required drug; the jet generation module includes: a metal wire implosion drive unit and a nozzle; the metal wire implosion drive unit includes a high-energy current module and a metal wire; the high-energy current module is used to: generate a high-energy current, so that the metal wire instantly reaches a high-temperature state, and drive the drug solution to form a high-speed fluid The nozzle is configured to convert the high-speed fluid into a jet according to the direction and velocity of the jet determined by the jet parameter setting module. The nozzle's jet angle and diameter are both adjustable. Adjusting the nozzle's jet angle adjusts the jet's jet angle; adjusting the nozzle's diameter adjusts the jet's jet velocity. The sensor module monitors the distribution of the drug solution in the body in real time; the distribution includes drug concentration and location information. The precision delivery module controls the jet parameter setting module to adjust the jet's direction and velocity in real time based on the distribution of the drug solution in the body and the drug delivery requirements. This application utilizes electro-explosion technology, utilizing a high-energy current to excite a metal wire, causing it to instantly reach a high temperature. The implosion effect generates extremely high temperatures and pressures, thereby forming a high-speed jet. The jet's velocity can reach or exceed 1 km / s, providing sufficient kinetic energy to effectively penetrate human tissue and achieve precise drug delivery to deep target areas. Furthermore, sensors monitor the distribution of the drug solution in the body in real time and adjust the jet's direction and velocity accordingly, ensuring accurate delivery of the drug jet to deep tissue. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0016] Figure 1 This is a schematic structural diagram of an ultrahigh-speed jet drug delivery device provided in one embodiment of the present application. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0018] The working principle, structural composition and relationship of the existing needle-free injection device are described in detail as follows:

[0019] Working principle:

[0020] Needle-free injection devices mix drugs with gas or liquid and use high pressure to eject the mixture. The working steps usually include the following steps:

[0021] Drug preparation: The drug to be delivered is dissolved or suspended in a suitable carrier liquid to form a drug solution.

[0022] Pressurization process: The drug solution is pressurized using compressed gas (such as nitrogen or air) or liquid (such as water), usually in the pressure range of 1-10 MPa.

[0023] Spraying process: The pressurized medicine is sprayed into tiny droplets or mist through a specially designed nozzle, penetrating the surface of the skin and entering the subcutaneous tissue or muscle.

[0024] Drug release and absorption: After the drug is released at the target site, it relies on the tissue's absorption mechanism to enter the blood circulation and exert its efficacy.

[0025] Structural composition:

[0026] The main structural components of the needle-free injection device include:

[0027] Drug storage containers: These are used to store drug solutions to be delivered, typically in replaceable syringes or dedicated drug bottles. The container material must possess good chemical stability to prevent drug degradation.

[0028] Pressurization system: This includes a compressed gas tank or liquid pump, responsible for pressurizing the drug solution to the required injection pressure. The pressurization system should be designed to ensure stable pressure and avoid gas or liquid leakage.

[0029] Nozzle: A key component of a needle-free injection device, responsible for converting pressurized drug solution into fine mist or droplets.

[0030] The nozzle design usually adopts a narrow throat and a specific nozzle angle to achieve high-speed spraying of the drug.

[0031] Different types of nozzles (such as flat spray, cone spray, etc.) can be used in different application scenarios.

[0032] Control system: includes pressure monitor and injection controller to ensure real-time monitoring and adjustment of injection pressure and frequency during operation.

[0033] The control system may be equipped with a touch screen or other human-machine interface to facilitate operator setting of parameters.

[0034] Safety mechanism: It is designed with multiple safety protection measures, such as protection against overpressure, drug leakage and misoperation.

[0035] Some devices may be equipped with protective covers to protect the operator and patient.

[0036] Although the current needle-free injection technology has improved patient comfort to a certain extent, it still has the following shortcomings:

[0037] Limited delivery depth: The drug delivery depth of existing needle-free injection technologies is generally limited to the subcutaneous or muscle layer and cannot effectively reach deeper tissues (such as internal organs).

[0038] Low drug bioavailability: Due to the diffusion and absorption characteristics of drugs in the body, the bioavailability of some drugs still cannot reach the ideal level when using needle-free injection technology.

[0039] Insufficient targeting: Existing needle-free injection technologies typically use systemic delivery and lack targeting to specific tissues or organs. This can lead to drug accumulation in non-targeted areas, increasing side effects and reducing therapeutic efficacy.

[0040] Drug loss: During the spraying process, drug may be lost due to atomization and diffusion, resulting in a lower amount of drug actually delivered to the target site than expected.

[0041] Delivery rate limitation: The injection rate of existing technologies is usually low, resulting in slow drug entry into the body, which cannot meet clinical needs, especially in emergency situations or situations where rapid drug effect is required.

[0042] Based on the above-mentioned existing technologies, this embodiment considers how to achieve efficient and deep drug delivery to overcome the limitations of existing drug delivery methods (such as needle-free injection and targeted drugs) in terms of delivery depth and targeting.

[0043] This embodiment addresses the shortcomings of the existing needle-free injection technology and aims to achieve deeper drug delivery by exceeding the jet velocity of 1 km / s. The innovations of this system mainly include:

[0044] Using ultra-high-speed jet technology, drugs are delivered in the form of ultra-high-speed jets, which can effectively penetrate the skin and other biological barriers and reach deeper tissues.

[0045] Enhanced drug targeting: This system can be combined with image guidance or smart sensor technology to monitor the location of the drug during delivery in real time, ensuring that the drug can accurately reach the target area.

[0046] Efficient drug utilization: Due to the use of high-speed jet technology, the loss of drugs in vitro can be reduced, thereby improving bioavailability and ensuring that higher drug concentrations reach the target tissue.

[0047] Versatility: This system can adjust the jet velocity and drug release mode according to different drug properties and treatment needs to adapt to different clinical applications.

[0048] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the present application is further described in detail below with reference to the accompanying drawings and specific implementation methods.

[0049] In an exemplary embodiment, Figure 1 As shown, an ultra-high-speed jet drug delivery device is provided, which includes: a jet parameter setting module, a jet generation module, a sensor module and a precision delivery module.

[0050] The jet parameter setting module is used to determine the direction and speed of the jet according to drug delivery requirements; the drug delivery requirements include: location information of the lesion site and concentration information of the required drug.

[0051] The jet generation module includes a wire implosion drive unit and a nozzle.

[0052] The wire implosion drive unit includes a high-energy current module and a wire.

[0053] The high-energy current module is used to generate high-energy current to make the metal wire reach a high-temperature state instantly, and drive the drug solution to form a high-speed fluid.

[0054] The nozzle is used to: convert the high-speed fluid into a jet according to the direction and speed of the jet determined by the jet parameter setting module; the injection angle and diameter of the nozzle can be adjusted; adjusting the injection angle of the nozzle can adjust the injection angle of the jet; adjusting the diameter of the nozzle can adjust the injection speed of the jet.

[0055] The sensor module is used to monitor the distribution of the drug solution in the body in real time; the distribution includes: drug concentration and location information.

[0056] The precision delivery module is used to: control the jet parameter setting module in real time to adjust the direction and speed of the jet according to the distribution of the drug solution in the body and the drug delivery requirements.

[0057] The jet generating module further includes:

[0058] Water cooling system for cooling.

[0059] The control system is used to generate control instructions according to the direction and speed of the jet determined by the jet parameter setting module; the control instructions are used to control the spray angle and diameter of the nozzle.

[0060] The control system further comprises an electric valve for controlling the switch of the flow of the drug solution; and controlling the flow of the drug solution by adjusting the opening of the electric valve.

[0061] Wherein, the ultrahigh-speed jet drug delivery device further includes: a targeted delivery mechanism.

[0062] The targeted delivery mechanism includes:

[0063] A biomarker selection module is used to determine the type of biological targeting factor according to the characteristics of the target tissue; the biological targeting factor includes: a targeting molecule or a biomarker;

[0064] The drug preparation module is used to mix the biological targeting factor and the drug to form a drug solution.

[0065] The sensor module specifically includes:

[0066] Drug concentration sensors are used to monitor the concentration of mixed drugs in the body in real time using fluorescence, spectroscopy or electrochemical methods.

[0067] Position sensors are used to track the distribution of drugs in the body in real time using ultrasound or magnetic resonance methods.

[0068] Biomarker recognition sensors are used to detect the presence and concentration of biotargeting factors through signal transduction mechanisms.

[0069] The drug preparation module specifically includes:

[0070] The drug input port is used to input drugs.

[0071] The biomarker or targeting molecule input port is used to input bio-targeting factors; the bio-targeting factors include: targeting molecules or biomarkers.

[0072] Mixing tank, used to mix the drug with the bio-targeting factor.

[0073] The stirrer is arranged in the mixing tank and is used to stir the drugs and biological targeting factors.

[0074] The filter is arranged at the outlet of the mixing tank and is used to filter impurities and insoluble particles in the mixed drug solution.

[0075] The drug carrier output port is used to output the filtered solution.

[0076] The ultra-high-speed jet drug delivery device further includes a drug carrier system for determining the physicochemical properties of the drug and recommending a matching carrier type based on the physicochemical properties.

[0077] The drug carrier system specifically includes: a drug analysis module and a carrier selection module.

[0078] The drug analysis module includes: a liquid chromatograph or an ultraviolet-visible spectrometer.

[0079] The drug analysis module is used to determine the physical and chemical properties of the drug.

[0080] The carrier selection module is used to recommend a matching carrier type based on the physicochemical properties of the drug. The matching carrier type is a carrier type that is compatible with the drug.

[0081] The ultra-high-speed jet drug delivery device further includes a data processing module.

[0082] The data processing module is used to:

[0083] Acquire the patient's real-time physiological data; transmit the real-time physiological data and the distribution of the drug solution in the body to a remote terminal and record them.

[0084] The ultra-high-speed jet drug delivery device further includes: a user interface.

[0085] The user interface is used to: allow users to set parameters; issue alarms when abnormal situations occur; allow users to view historical data; and provide users with operation manuals and help information.

[0086] The shell of the ultra-high-speed jet drug delivery device is biocompatible.

[0087] Specifically, the ultrahigh-speed jet drug delivery device provided in this embodiment may include the following modules and specific implementation methods:

[0088] Drug carrier system: The drug is pre-treated with a specific carrier solution to ensure drug stability and activity during the ultra-high-speed jet process. The appropriate carrier can be selected based on different drug properties (such as water solubility, lipid solubility, etc.) to achieve optimal drug release.

[0089] Drug carrier systems play a crucial role in ultrahigh-speed fluidic drug delivery. By selecting an appropriate drug carrier solution, drug stability and activity can be maintained during ultrahigh-speed fluidization, thereby improving drug bioavailability and therapeutic efficacy. The physicochemical properties of different drugs (such as water solubility and lipid solubility) determine their appropriate carrier type, which in turn affects the drug's release rate and biocompatibility.

[0090] Key parameters of drug carriers:

[0091] Water-soluble drugs: It is suitable to choose water-based carriers, such as normal saline, buffer solution, etc., to ensure the solubility and stability of the drug in the carrier.

[0092] Lipid-soluble drugs: Oil-based carriers or emulsions can be selected to increase the solubility of the drug in the carrier and promote drug penetration through the cell membrane.

[0093] Biocompatibility of the carrier: The carrier should be compatible with human tissue to ensure that it does not cause allergic reactions or other side effects during drug delivery.

[0094] Rheological properties of the carrier: The viscosity and fluidity of the carrier should be suitable for maintaining uniform dispersion of the drug during ultra-high-speed injection and avoiding drug precipitation or aggregation.

[0095] Drug carrier system:

[0096] Drug property analysis: Analysis of the physicochemical properties of the drug to be delivered (such as solubility, stability, etc.).

[0097] Carrier selection: Select a suitable carrier solution (such as water-based or oil-based) based on the properties of the drug.

[0098] Drug dissolution: dissolve the drug in the selected carrier and ensure uniform dispersion of the drug in the carrier.

[0099] Stability testing: Stability testing of drug-carrier mixtures is performed to ensure that the activity of the drug in the carrier is not affected and to evaluate its performance under ultrahigh-speed jet conditions.

[0100] Storage and preparation: The drug carrier solution that has passed the stability test is stored for subsequent ultrahigh-speed jet operation.

[0101] The overall architecture of the drug carrier system includes the mixing of drug and carrier, stability testing and injection preparation. Key components include:

[0102] Drug analysis module: used to analyze the physical and chemical properties of drugs.

[0103] Carrier selection module: automatically recommends appropriate carrier types based on drug characteristics.

[0104] Preparation module: mixing of drugs and carriers and stability testing.

[0105] Storage module: Store the prepared drug carrier solution to suitable conditions.

[0106] The chronological order of the various steps in the drug carrier system and their interrelationships are as follows:

[0107] Drug analysis start: The system starts analyzing the drug to be delivered.

[0108] Vector selection: Based on the analysis results, the system recommends a suitable vector.

[0109] Drug dissolution and mixing: The drug and carrier are mixed under certain conditions to form a stable drug-carrier solution.

[0110] Stability testing: Monitoring a mixture to ensure its stability over a specified period of time.

[0111] Preparation completed: The preparation of the drug carrier solution is completed and enters the storage stage.

[0112] In order to realize the functions of the above-mentioned drug carrier system, a complete system device is required, including the following main components:

[0113] Drug analysis unit: equipped with equipment such as high performance liquid chromatography (HPLC) or UV-visible spectrometer to analyze the properties of drugs in real time.

[0114] Carrier Selection System: Based on drug analysis results, a computer algorithm is used to automatically select the optimal carrier. The system can be integrated with a database containing information on the compatibility of different drugs and carriers.

[0115] Mixer: It has high shear mixing function to ensure uniform mixing of drugs and carriers, and can adjust mixing time and speed to meet the needs of different drugs.

[0116] Stability detection module: Use dynamic light scattering (DLS) or other detection methods to monitor the stability of drug carrier solution in real time to ensure that drug activity is not affected.

[0117] Storage and delivery system: stores the prepared drug carrier solution and delivers it to the ultra-high-speed jet device through a pump system.

[0118] Targeted delivery mechanism: By combining biomarkers or specific targeting molecules, precise targeted delivery to specific tissues or cells is achieved by adjusting the jet direction and speed. A real-time monitoring system is used, sensors are used to detect the distribution of drugs in the body, and the jet parameters are dynamically adjusted to optimize the delivery effect. The ultra-high-speed jet drug delivery system of this embodiment is designed to achieve precise targeted drug delivery to specific tissues or cells by combining biomarkers or specific targeting molecules and utilizing a jet speed of more than 1 km / s. The system adjusts the direction and speed of the jet so that the drug can reach the predetermined target efficiently and accurately, thereby improving the bioavailability and therapeutic effect of the drug.

[0119] Targeted delivery mechanism:

[0120] Biomarker selection: By analyzing the characteristics of target tissues or cells, appropriate biomarkers are selected to enhance the targeting of drugs.

[0121] Targeted molecule binding: The selected biomarker is combined with the drug to form a drug carrier with specific targeting.

[0122] Jet parameter setting: Set the direction and speed of the jet according to the distance, shape and required delivery depth of the target.

[0123] Real-time monitoring: Sensors are used to monitor the distribution of drugs in the body, including drug concentration, target location and other information.

[0124] Dynamically adjust the jet: Based on real-time monitoring results, dynamically adjust the jet parameters to optimize the drug delivery effect.

[0125] Precision delivery: Ensure that the drug reaches the target tissue or cells accurately to achieve efficient treatment.

[0126] Basic components of targeted delivery system:

[0127] Drug carrier: A complex containing a drug and a biomarker.

[0128] Targeting molecules: Molecular structures that are directed to specific cells or tissues to enhance targeting.

[0129] Jet Generator: A device that generates ultra-high-speed jets and can adjust the speed and direction of the jet.

[0130] Sensor: monitors the distribution of drugs in the body in real time, and detects drug concentration and location information.

[0131] Control system: Based on sensor data, the jet parameters are adjusted in real time to ensure accurate drug delivery.

[0132] Feedback regulation: Optimize fluidic parameters and drug delivery strategies based on feedback information.

[0133] Targeted delivery timing steps:

[0134] Sensors collect drug distribution data: real-time monitoring of drug distribution in the body.

[0135] Data is sent to the central control unit: The collected data is transmitted to the central control unit.

[0136] The central control unit analyzes data: analyzes real-time data to determine the targeted delivery of drugs.

[0137] The control instructions are sent to the jet control module: adjustment instructions are issued based on the analysis results.

[0138] The jet control module adjusts the jet parameters: the speed and direction of the jet are adjusted in time to optimize drug delivery.

[0139] Precise drug delivery to the target: ensuring that the drug reaches the target tissue or cell accurately and efficiently to achieve the best therapeutic effect.

[0140] The ultrahigh-speed jet drug delivery device provided in this embodiment includes the following main components:

[0141] 1. Drug Preparation Module: This module is responsible for combining drugs with biomarkers or targeting molecules to form targeted drug carriers. It has stirring, mixing, and filtering functions to ensure drug uniformity and stability.

[0142] The drug preparation module is a core part of the system and usually includes the following key components:

[0143] (1) Drug input port: the interface for inputting raw drug.

[0144] (2) Biomarker or targeting molecule input port: an interface for inputting targeting molecules or biomarkers.

[0145] (3) Mixing tank: A container used to mix the drug with the biomarker or targeting molecule.

[0146] (4) Agitator: Installed in the mixing tank, responsible for stirring and mixing the drug ingredients to ensure uniformity and stability.

[0147] (5) Filter: Located at the outlet of the mixing tank, it ensures that the mixed drug carrier is free of impurities and insoluble particles.

[0148] (6) Drug carrier output port: an interface for outputting the prepared targeted drug carrier.

[0149] Detailed design:

[0150] (1) Mixing tank: Made of high-performance materials, it has good corrosion resistance and high temperature resistance, and the internal surface is smooth to reduce drug adhesion.

[0151] (2) Stirrer: The speed can be adjusted to meet the mixing requirements of different drugs and ensure sufficient mixing. A magnetic stirrer or mechanical stirrer can be considered.

[0152] (3) Filter: Microfiltration or ultrafiltration technology can be used to effectively remove tiny particles and ensure the purity of the drug carrier.

[0153] 2. Jet Generator: A high-speed jet is generated by imploding a metal wire in water. A nozzle design can be used to adjust the jet angle and velocity. The jet device must be designed to meet biocompatibility standards to avoid harm to the human body.

[0154] The jet generating device is a key component of the ultrahigh-speed jet drug delivery system, used to generate high-speed jets to efficiently deliver drug carriers to the target site. The device mainly includes the following components:

[0155] (1) Wire implosion drive unit: the core part used to generate the implosion effect to drive the jet.

[0156] (2) Nozzle: designed to control the spray angle and speed of the jet.

[0157] (3) Water cooling system: used to control equipment temperature and ensure stable operation.

[0158] (4) Control system: responsible for adjusting the opening and closing of the nozzle, jet speed and injection angle.

[0159] (5) Biocompatible housing: The external structure that ensures that the device is harmless to the human body.

[0160] Detailed design:

[0161] Wire Implosion Driver:

[0162] Design: Highly conductive metal wire is used, which can heat up quickly in water and produce an implosion effect. The material and diameter of the metal wire should be optimized to ensure efficient energy transfer and the formation of high-speed jets.

[0163] nozzle:

[0164] Function: The high-speed fluid generated inside is converted into a jet through the nozzle. The design of the nozzle must take fluid mechanics into consideration to achieve the best spraying effect.

[0165] Design: The nozzle angle and diameter can be adjusted to suit different application requirements. The nozzle material must have good biocompatibility to prevent damage to the drug and the human body.

[0166] Water cooling system:

[0167] Function: Keep the temperature of the equipment stable during operation to prevent equipment failure due to overheating.

[0168] Design: A cooling water circulation system is configured to ensure that the metal wires and other electronic components operate within a safe temperature range.

[0169] Control system:

[0170] Function: Monitor and adjust various jet parameters, including jet speed, angle and flow rate, to achieve precise drug delivery.

[0171] Design: Use a microprocessor or programmable logic controller (PLC) in conjunction with sensors (such as flow sensors, pressure sensors) to provide real-time feedback and adjust the nozzle opening and closing status and spray intensity.

[0172] Interface: Design a human-computer interaction interface that allows users to set and monitor operating parameters to ensure ease of use and safety.

[0173] Biocompatible housing:

[0174] Function: Provide overall structural support and ensure the safety of the device when in contact with the human body.

[0175] Design: The housing material should be selected from materials that meet biocompatibility standards, such as polymers or coated metals, to avoid any possible allergic or toxic reactions.

[0176] Sealing: The housing design must have good sealing performance to ensure that the internal components are protected from external contamination and water intrusion.

[0177] 3. Sensor system: This includes multiple sensors, such as drug concentration sensors, position sensors, and biomarker recognition sensors, to monitor drug distribution in the body in real time. The sensor data acquisition frequency must be high enough to support real-time feedback and regulation.

[0178] Components of the sensor system

[0179] (1) Drug concentration sensor:

[0180] Function: Real-time monitoring of drug concentration in the body to ensure the effectiveness and safety of drug delivery.

[0181] Working principle: Fluorescence, spectroscopy or electrochemistry techniques can be used to quickly respond to changes in drug concentration in the body.

[0182] (2) Position sensor:

[0183] Function: Track the distribution of drugs in the body to ensure that the drugs reach the target site accurately.

[0184] How it works: Uses ultrasound, magnetic resonance imaging, or other imaging technologies to provide real-time location information.

[0185] (3) Biomarker recognition sensor:

[0186] Function: Identify specific biomarkers to determine the targeting and biocompatibility of drugs.

[0187] Working Principle: Specific antibodies, nucleic acid probes, or other biorecognition molecules bind to target biomarkers and detect their presence and concentration through signal transduction mechanisms (such as fluorescence, chemiluminescence, or electrical signal changes). Application Scenarios: These can be used to monitor tumor markers, inflammatory factors, and other indicators to assess drug efficacy and targeting.

[0188] Data processing and feedback mechanism

[0189] Data processing module:

[0190] Function: Receives information from various sensors and performs real-time analysis and processing. Based on the monitoring data, it provides feedback and adjustment basis for the drug delivery system.

[0191] Data collection frequency: This module needs to have high-frequency data collection capabilities to achieve real-time monitoring of drug concentration, location, and biomarkers, ensuring timely adjustment of delivery strategies during the drug delivery process.

[0192] Feedback channel:

[0193] Function: Based on the results of sensor data analysis, feedback is given to the control unit of the drug delivery device to dynamically adjust the drug release rate and release site.

[0194] Implementation method: Precise control of drug delivery can be achieved through electronically controlled valves and pump adjustments to ensure optimal drug efficacy in the body.

[0195] Interaction of the whole system:

[0196] System interaction: Efficient interaction between the sensor system, data processing module and control unit is the key to the success of the ultrahigh-speed jet drug delivery system.

[0197] When the drug concentration sensor detects that the drug concentration is lower than the set threshold, the data processing module will quickly analyze and adjust the drug release rate through the feedback channel.

[0198] When the position sensor detects that the drug fails to reach the intended target, the system adjusts the jet direction and intensity based on real-time position information to ensure accurate drug delivery.

[0199] Feedback provided by biomarker recognition sensors can be used to assess the biocompatibility and therapeutic efficacy of drugs, thereby optimizing drug combinations in real time.

[0200] Medical Monitoring: The entire system not only monitors drug delivery in real time but also transmits important physiological data and drug concentration information to medical personnel through a data processing module, enabling remote monitoring and data logging. This monitoring helps doctors understand patients' responses and adjust treatment plans in a timely manner.

[0201] Intelligent Adjustment: By analyzing historical data using machine learning algorithms, the system can continuously optimize drug delivery strategies, improving the personalization and precision of treatment. For example, the system can learn from different patients' responses to medications and adjust the dosage and drug type in subsequent treatments.

[0202] Sensor System Design Considerations

[0203] Sensor selection: Depending on the characteristics of the drug and the therapeutic goal, the appropriate sensor type is selected. For example, electrochemical sensors may be more suitable for some drugs, while optical sensors may be more suitable for others.

[0204] Ensure sensor sensitivity and selectivity to obtain accurate readings in complex biological environments.

[0205] Sensor layout: Sensors need to be reasonably arranged to ensure coverage of all drug delivery locations and obtain comprehensive monitoring data.

[0206] Sensors should be miniaturized and biocompatible to reduce invasiveness and improve patient comfort.

[0207] 4. Control system: The central control unit is responsible for integrating information from different sensors, performing data processing and decision-making.

[0208] It has a real-time analysis algorithm that can dynamically adjust the jet parameters according to monitoring data to achieve precise control.

[0209] The core of the control system is the central control unit, whose main responsibility is to integrate information from various sensors and monitor and adjust the operation of the drug delivery system in real time. The entire control system architecture includes the following main components: central control unit, sensor module, actuator, user interface, data communication module

[0210] Central Control Unit (CCU):

[0211] Functional description: The central control unit is the "brain" of the system, responsible for processing the data collected by sensors, analyzing it, and making decisions based on it. Its main functions include:

[0212] (1) Data integration: Collect real-time data from each sensor module, including pressure, flow, temperature, and position information.

[0213] (2) Data processing: Use real-time analysis algorithms to process the collected data and identify system status and work efficiency.

[0214] (3) Dynamic adjustment: Based on the data analysis results, the jet parameters (such as flow rate, injection angle, drug dosage, etc.) are adjusted in real time to ensure the precise positioning and effectiveness of the drug.

[0215] (4) Fault detection: Monitor the system's operating status, promptly detect and handle possible faults or abnormal conditions, and ensure the safety and stability of the system.

[0216] Components:

[0217] (1) Processor: A high-performance microcontroller or FPGA for fast data processing and algorithm execution.

[0218] (2) Memory: used to store algorithms, historical data and system configuration parameters.

[0219] (3) Interface module: includes interfaces for communicating with sensors, actuators, and user interfaces (such as serial ports, CAN bus, I2C, etc.).

[0220] Sensor Module:

[0221] The sensor module is composed of multiple sensors that monitor key parameters during drug delivery in real time:

[0222] (1) Pressure sensor: monitors the pressure changes of the jet to ensure that the drug can be ejected at the required pressure.

[0223] (2) Flow sensor: monitors the drug flow rate in real time to ensure that the drug delivery volume meets the preset dosage and prevent overdose or underdose.

[0224] (3) Temperature sensor: monitors the temperature of the drug and the jet environment to ensure that the drug is delivered within the appropriate temperature range to avoid drug ineffectiveness or deterioration.

[0225] (4) Position sensor: used to monitor the position and direction of the drug delivery device to ensure that the drug can accurately reach the intended target.

[0226] (5) These sensors send information to a central control unit via analog or digital signals, allowing efficient real-time monitoring and control of the system.

[0227] Actuator:

[0228] The actuator is the part of the control system that implements the specific drug delivery action. It is mainly responsible for responding to the instructions of the central control unit and adjusting the injection parameters of the drug. The types of actuators include:

[0229] (1) Electric valve: controls the flow switch of the drug and accurately controls the flow by adjusting the opening of the valve.

[0230] (2) Nozzle: Adjusts the spray angle and spray mode (such as continuous spray or pulse spray) according to the instructions of the central control unit to achieve different drug delivery strategies.

[0231] The response time and accuracy of the actuator are key factors affecting the drug delivery effect. The central control unit continuously adjusts the working state of the actuator through feedback information to ensure the accuracy and effectiveness of drug delivery.

[0232] user interface

[0233] The user interface provides an interactive platform between the operator and the ultra-high-speed jet drug delivery system, enabling the following functions:

[0234] (1) System monitoring: Real-time display of data from various sensors (such as flow, pressure, temperature, etc.) allows operators to intuitively understand the system operating status.

[0235] (2) Parameter setting: The operator can set and adjust the relevant parameters of drug delivery (such as dosage, flow rate, injection time, etc.) through the interface.

[0236] (3) Alarm prompt: The system can automatically issue an alarm when an abnormal situation occurs (such as excessive pressure, insufficient flow, abnormal temperature, etc.). The user interface will remind the operator visually and auditorily so that timely measures can be taken.

[0237] (4) Historical data recording: The system can record historical data during operation to facilitate subsequent analysis and optimization. The user interface allows the operator to view historical data to evaluate the effectiveness of drug delivery and system performance.

[0238] (5) Operation manual and help information: The interface provides relevant operation manual and help information to guide operators on how to use the system correctly and deal with common problems.

[0239] The user interface can take various forms, such as a touch screen, PC, or mobile device, to ensure that operators can easily interact with the system. The interface should be designed to be user-friendly and easy to operate to improve work efficiency.

[0240] Data communication module:

[0241] The data communication module is responsible for information exchange between the control system and external devices, ensuring that the system can operate efficiently and stably. Its main functions include:

[0242] (1) Data transmission: Sensor data, actuator status, and user instructions are transmitted to the central control unit via wireless communication (such as Wi-Fi, Bluetooth) or wired communication (such as Ethernet, serial port) to ensure the real-time and accuracy of the system.

[0243] (2) Remote monitoring: The data communication module supports remote monitoring functions, allowing operators to access the system's real-time data and status through the Internet and perform remote configuration and debugging.

[0244] (3) Data synchronization: Synchronize and integrate data with other devices (such as hospital information systems, electronic medical record systems, etc.) to facilitate data sharing and use and improve the overall efficiency of the system.

[0245] The stability and security of data communication modules are of vital importance. Appropriate encryption measures and protection mechanisms must be adopted to ensure the confidentiality and integrity of transmitted data.

[0246] The control system workflow is as follows:

[0247] (1) Data acquisition: Various sensors monitor important parameters during drug delivery in real time and transmit the data to the central control

[0248] (2) Data processing: After receiving sensor data, the central control unit performs real-time analysis and processing. The system evaluates the current drug delivery status and performance through a preset algorithm.

[0249] (3) Decision making: Based on the analysis results, the central control unit determines whether it is necessary to adjust the drug delivery parameters (such as flow rate, pressure, drug dosage, etc.). If the system detects an abnormality (such as excessive pressure or insufficient flow), the fault detection function will be triggered.

[0250] (4) Instruction issuance: The central control unit issues instructions to the actuators based on the decision, adjusting the required drug delivery parameters. The actuators perform corresponding actions according to the instructions, such as opening or closing the electric valve, adjusting the nozzle angle, or changing the operating state of the pump.

[0251] (5) Feedback loop: After the actuator performs an operation, the relevant sensors continuously monitor the new system status and feed the data back to the central control unit. The central control unit compares the feedback data with the target parameters to determine whether the delivery effect meets the expectations.

[0252] (6) User Interaction: The operator can view system status and parameter information in real time through the user interface and can manually adjust parameters or respond to system alarms when necessary. All operations are recorded in the system for subsequent analysis.

[0253] (7) Data recording and analysis: The system continuously records operating data, and operators can review historical data when needed to evaluate the effectiveness of drug delivery and optimize future operating procedures.

[0254] (8) Remote Monitoring and Maintenance: Through the data communication module, operators can remotely monitor the system status and make necessary adjustments and maintenance. At the same time, the data synchronization function enables the system to be integrated with other medical equipment and information systems, improving overall efficiency and patient safety.

[0255] 5. Feedback Regulation Mechanism: Establish a feedback loop to ensure the system can adaptively optimize drug delivery strategies based on real-time monitoring results. The feedback regulation mechanism includes software algorithms and hardware interfaces to ensure efficient operation of the system.

[0256] Feedback loop: The feedback regulation mechanism aims to dynamically adjust the drug delivery strategy by real-time monitoring of key parameters during the drug delivery process (such as drug concentration, jet velocity, and physiological status of the application site), thereby achieving precise and efficient drug release. This mechanism consists of a data acquisition module, a processing module, and an execution module, forming a closed-loop control system.

[0257] Hardware interface:

[0258] Sensor Module:

[0259] (1) Drug concentration sensor: real-time monitoring of drug concentration in the jet, using optical or electrochemical sensors.

[0260] (2) Flow rate sensor: detects the speed of the drug jet and ensures that it is within the preset range.

[0261] (3) Physiological parameter sensors: such as temperature, pH value, tissue pressure, etc., to monitor the physiological status of the application site.

[0262] Control unit:

[0263] (1) Microprocessor or embedded system: processes and makes decisions based on the data fed back by sensors.

[0264] (2) Communication interface: supports data exchange with other modules (such as user interface, data storage and remote monitoring system).

[0265] Actuator module:

[0266] (1) Drug delivery device: adjusts the drug release rate or jet intensity according to the control signal, and may use a pump or pneumatic device.

[0267] (2) Feedback prompt device: such as LED indicator light or sound alarm, indicating system status and operation results.

[0268] Software Algorithm

[0269] (1) Data acquisition and preprocessing: Regularly obtain data from the sensor module and perform filtering and noise suppression to ensure data accuracy.

[0270] (2) Decision-making algorithm:

[0271] Real-time optimization algorithm: Based on the acquired data, machine learning or the PID algorithm (proportional-integral-derivative control) in control theory are used to adjust drug delivery parameters in real time.

[0272] Machine learning models: Utilize historical data to train models and predict the impact of different parameters on drug delivery, thereby selecting the optimal parameter combination. Models can include supervised learning (e.g., regression analysis) and unsupervised learning (e.g., cluster analysis) to adapt to different clinical needs and individual differences.

[0273] Control Theory Applications: Using feedback control theory, we can design adaptive controllers to adjust drug release rate and jet intensity in real time in response to changes in physiological parameters. For example, we can use fuzzy controllers to handle uncertainty and optimize drug delivery strategies.

[0274] Adaptive control algorithms dynamically adjust drug delivery strategies based on real-time monitoring data. The system can learn from historical data and identify patterns to refine future drug release strategies. For example, based on drug concentration and physiological feedback, the system can automatically adjust the release rate and interval to optimize therapeutic efficacy.

[0275] Threshold control: Set safety thresholds for key parameters (such as the upper limit of drug concentration, the lower limit of jet velocity, etc.). Once these thresholds are exceeded or lowered, the system will automatically issue an alarm and adjust the drug release strategy to prevent adverse reactions or treatment failure.

[0276] Data analysis and feedback mechanism:

[0277] (3) Data analysis and decision support:

[0278] Real-time monitoring and data analysis: The system continuously collects and analyzes sensor data during operation to identify trends and anomalies. Using data mining algorithms (such as time series analysis), the system can identify the optimal timing and dosage for drug release.

[0279] User Interface and Feedback: Provides a visual interface that displays various monitoring parameters and system status in real time, helping operators monitor and make decisions. Regularly generates operation reports to help medical staff evaluate drug delivery effectiveness and provide optimization recommendations.

[0280] Real-time data monitoring: Build a visual interface to display data such as drug concentration, flow rate, and physiological parameters in real time for medical staff to refer to.

[0281] Historical data recording and analysis: The system will record detailed data of each drug delivery and analyze this data through machine learning technology to identify effective drug delivery patterns and trends, providing a basis for future treatment plans.

[0282] User interface: Users can set the target parameters of drug delivery through the graphical user interface (GUI), including drug type, target concentration, jet velocity, and dosing frequency.

[0283] Feedback interface: The system will provide real-time feedback on the status of drug delivery, such as success rate, current concentration, physiological status of the administration site, etc., to help users make better decisions.

[0284] (4) Adaptive algorithm:

[0285] The system can adaptively adjust the drug release strategy based on physiological feedback from the administration site (such as drug absorption efficiency, tissue response, etc.). For example, if it detects that the tissue responds poorly to the drug, the system will automatically reduce the drug release rate or adjust the drug type and dosage.

[0286] System Integration:

[0287] The close integration of hardware and software modules ensures that sensor data can be quickly transmitted to the control unit and control signals are fed back to the actuator in a timely manner.

[0288] The modular design enables each hardware component and software function to be independently upgraded and optimized. Before actual application, different drug delivery strategies are tested through computer simulation to evaluate their effectiveness and safety. By establishing a computer model, virtual experiments are conducted on the drug delivery process to evaluate the impact of different parameter settings (such as drug concentration, dosing frequency, and flow rate) on the therapeutic effect. This simulation can help the research team identify potential problems and make pre-adjustments without facing risks in actual experiments. Existing clinical data can be used for regression analysis to verify the accuracy and reliability of the model.

[0289] Feedback mechanism optimization: During the testing phase, feedback data is collected and the control algorithm and parameters are continuously adjusted to improve the system response speed and accuracy. For example, in response to delays or deviations observed during drug release, the parameters of the PID controller are adjusted to optimize the sensitivity of the control algorithm.

[0290] This embodiment has the following advantages:

[0291] 1. Improved drug delivery depth: This embodiment uses an ultra-high-speed jet at speeds exceeding 1 km / s to effectively penetrate the skin's biological barrier and reach deep tissues. This rapid delivery method significantly increases drug delivery depth, ensuring that the drug reaches the target tissue, thereby enhancing therapeutic efficacy.

[0292] 2. Enhanced drug bioavailability: Through ultra-high-speed jets, drugs can be absorbed into the blood circulation system in a shorter time, reducing the drug's local retention time, thereby improving drug bioavailability. This is especially important for drugs that require rapid onset of action (such as anesthetics, analgesics, etc.).

[0293] 3. Expanded scope of application: This embodiment can effectively deliver various types of drugs, including high-viscosity drugs, granular drugs, and other drugs that are difficult to deliver through existing needle-free injection technology, meeting different clinical needs and expanding the scope of application of drug delivery.

[0294] In addition, this application also provides several other embodiments:

[0295] Example 2: Anti-tumor drug delivery:

[0296] Biomarkers specific to tumor cells are selected and combined with drugs to form targeted carriers. Through ultra-high-speed jets, drugs are rapidly delivered to tumor tissues. The concentration of drugs in the tumor area is monitored in real time, and jet parameters are dynamically adjusted to ensure optimal drug delivery.

[0297] Example 3: Vaccination:

[0298] By combining specific immune cell surface markers, vaccine drug carriers are prepared. Using ultra-high-speed fluidics technology, vaccines are rapidly delivered to muscle or lymphatic tissue to enhance immune responses. Sensors are used to monitor the activation status of immune cells after vaccination, allowing real-time adjustments to delivery strategies and improving vaccine effectiveness.

[0299] Example 4: Local analgesic delivery:

[0300] For patients with chronic pain, we select pain-related biomarkers and prepare analgesic drug carriers. We deliver drugs precisely to the painful area through ultra-high-speed fluidics, monitor the pain relief effect in real time, and adjust the drug dosage and delivery speed to achieve the optimal analgesic effect.

[0301] Example 5: Gene therapy:

[0302] For specific genetic diseases, gene vectors are combined with targeting molecules and delivered to target cells using ultra-high-speed fluidics. Sensors monitor gene expression and dynamically adjust the fluidics to ensure effective gene delivery to target cells, ultimately achieving the effectiveness of gene therapy.

[0303] Intelligent Control System (or Digital Human System, or Human Parameterized System): Equipped with an intelligent control system, it precisely adjusts the jet speed, pressure, and frequency based on the patient's physiological state and treatment needs. Using advanced algorithms and feedback mechanisms, it achieves automated control during the drug delivery process, ensuring on-demand drug release, maximizing therapeutic efficacy, and minimizing side effects.

[0304] The control system mainly consists of the following parts:

[0305] Sensor module: monitors the patient's physiological parameters (such as heart rate, blood pressure, body temperature, etc.) in real time and transmits the data to the control unit.

[0306] Control unit: Based on the data provided by the sensor, the algorithm calculates the optimal jet speed, pressure and injection frequency.

[0307] Actuator: According to the instructions of the control unit, it adjusts the speed, pressure and injection frequency of the jet to ensure the effective delivery of the drug.

[0308] User interface: Allows medical staff to input treatment requirements and monitor the drug delivery process in real time.

[0309] The workflow of the control system is as follows:

[0310] Data collection: The sensor module collects the patient's physiological data in real time through various physiological sensors (such as heart rate sensor, blood pressure sensor, temperature sensor, etc.). This data can reflect the patient's health status and response to medication.

[0311] Data processing: The control unit receives data from the sensor module and processes it using a pre-set algorithm (such as PID control algorithm, fuzzy control algorithm, etc.) to calculate the optimal jet parameters (speed, pressure, and jet frequency). This algorithm can dynamically adjust these parameters based on the patient's physiological state to achieve the best drug delivery effect.

[0312] Actuator feedback: The actuator adjusts the specific parameters of the jet according to the control unit's instructions and provides feedback to the control unit. This allows the control unit to continuously monitor the drug delivery process and make further adjustments if necessary.

[0313] User Interaction: The user interface allows medical staff to input specific treatment requirements and target data and monitor the status of drug delivery in real time. Through the user interface, medical staff can manually intervene in the control system to respond to unexpected changes or special circumstances.

[0314] Data Feedback Module: During drug delivery, the data feedback module continuously collects information about the actuator's operating status and the patient's response, ensuring the system can make appropriate adjustments based on real-time conditions. This mechanism can significantly improve the safety and effectiveness of drug delivery.

[0315] Control system timing

[0316] 1. The sensor module begins data acquisition. 2. After data acquisition is complete, the sensor module sends the data to the control unit. 3. The control unit receives the data and begins processing. 4. The control unit calculates the optimal fluidic parameters and sends instructions to the actuator. 5. The actuator adjusts the fluidic parameters and begins drug delivery. 6. The actuator provides feedback to the control unit. 7. The control unit makes necessary parameter adjustments based on this feedback. 8. The user interface displays the drug delivery status and patient physiological parameters in real time.

[0317] Advantages of the intelligent control system: The intelligent control system of the ultra-high-speed jet drug delivery system of this embodiment has the following significant advantages:

[0318] Personalized treatment: The control system can dynamically adjust drug delivery parameters based on each patient's real-time physiological data, thereby achieving personalized treatment to meet the specific needs of different patients.

[0319] Improve therapeutic effects: By precisely controlling the speed, pressure, and frequency of drug delivery, we ensure that drugs are released at the most appropriate time and conditions, thereby improving therapeutic effects.

[0320] Reduce side effects: The intelligent control system can monitor the patient's response in real time during drug delivery and adjust the drug dosage and delivery method in a timely manner, thereby reducing the occurrence of side effects.

[0321] Automation and intelligence: The system has a high degree of automation and intelligence, which reduces the operational burden on medical staff and reduces the risk of human error.

[0322] Real-time monitoring and feedback: Through the user interface, medical staff can monitor drug delivery status and patients’ physiological parameters in real time to ensure the safety and reliability of the treatment process.

[0323] The ultra-high-speed jet drug delivery system of this embodiment is applicable to various medical scenarios, including but not limited to:

[0324] Emergency Medicine: Rapid and precise delivery of medications to address critical situations in emergency situations.

[0325] Chronic Disease Management: Provide continuous medication delivery for patients with chronic diseases, adjusting drug dosage to adapt to patients' daily changes.

[0326] Surgery: During surgery, real-time control of drug delivery ensures the effectiveness of anesthesia or other drugs.

[0327] Clinical trials: used to study the delivery effects of new drugs and provide reliable data support.

[0328] This embodiment applies ultrahigh-speed jet technology to the technical field of drug delivery. By generating ultrahigh-speed jets and combining them with a drug delivery system, it is possible to achieve precise control of drug delivery, including dosage, depth, and targeting. This technology significantly improves the ability of drugs to penetrate the skin and other tissues, ensuring that the drugs can effectively reach deep tissues, which has not yet been achieved in existing needle-free injection technologies.

[0329] The ultrahigh-speed jet drug delivery system of this embodiment is adaptable to various types of drugs, including biological preparations, small molecule drugs, and vaccines, thus expanding the application scope of drug delivery.

[0330] This embodiment uses an intelligent control system to allow users to adjust the jet speed, pressure, and spray angle according to different drugs and treatment needs, provide personalized treatment plans, and provide feedback to optimize the efficiency and safety of drug delivery.

[0331] This embodiment supports multiple administration routes, such as subcutaneous, intramuscular, and local administration, which increases the flexibility of clinical application and meets the needs of different patients.

[0332] The technical features of the above embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0333] This document uses specific examples to illustrate the principles and implementation methods of this application. The description of the above examples is only intended to help understand the method and core concept of this application. At the same time, for those skilled in the art, based on the concept of this application, there may be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting this application.

Claims

1. An ultra-high-speed jet drug delivery device, characterized in that: The ultra-high-speed jet drug delivery device includes: a jet parameter setting module, a jet generation module, a sensor module and a precision delivery module; The jet parameter setting module is used to determine the direction and speed of the jet according to the drug delivery requirements; the drug delivery requirements include: the location information of the lesion site and the concentration information of the required drug; The jet generation module includes: a wire implosion drive unit and a nozzle; The wire implosion drive unit includes a high-energy current module and a wire; The high-energy current module is used to generate high-energy current to instantly make the metal wire reach a high-temperature state, thereby driving the drug solution to form a high-speed fluid; The nozzle is used to convert the high-speed fluid into a jet according to the direction and speed of the jet determined by the jet parameter setting module; the spray angle and diameter of the nozzle are adjustable; adjusting the spray angle of the nozzle can adjust the spray angle of the jet; adjusting the diameter of the nozzle can adjust the spray speed of the jet; The sensor module is used to monitor the distribution of the drug solution in the body in real time; the distribution includes: drug concentration and location information; The precision delivery module is used to: control the jet parameter setting module in real time to adjust the direction and speed of the jet according to the distribution of the drug solution in the body and the drug delivery requirements; The ultrahigh-speed jet drug delivery device further includes: a targeted delivery mechanism; The targeted delivery mechanism includes: A biomarker selection module is used to determine the type of biological targeting factor according to the characteristics of the target tissue; the biological targeting factor includes: a targeting molecule or a biomarker; A drug preparation module is used to mix the biological targeting factor and the drug to form a drug solution; The sensor module specifically includes: Drug concentration sensors, used to monitor the concentration of mixed drugs in the body in real time using fluorescence, spectroscopy or electrochemical methods; Position sensors, which use ultrasound or magnetic resonance methods to track the distribution of drugs in the body in real time; Biomarker recognition sensors are used to detect the presence and concentration of bio-targeting factors through signal transduction mechanisms.

2. The ultrahigh-speed jet drug delivery device according to claim 1, characterized in that: The drug preparation module specifically includes: A drug input port, used for inputting drugs; A biomarker or targeting molecule input port for inputting a bio-targeting factor; the bio-targeting factor includes: a targeting molecule or a biomarker; a mixing tank for mixing the drug with the biotargeting factor; A stirrer is provided in the mixing tank and is used to stir the drug and the biological targeting factor; A filter is provided at the outlet of the mixing tank to filter out impurities and insoluble particles in the mixed drug solution; The drug carrier output port is used to output the filtered solution.

3. The ultrahigh-speed jet drug delivery device according to claim 1, characterized in that: The ultra-high-speed jet drug delivery device further includes: a drug carrier system for determining the physicochemical properties of the drug and recommending a matching carrier type based on the physicochemical properties; The drug carrier system specifically includes: a drug analysis module and a carrier selection module; The drug analysis module includes: a liquid chromatograph or an ultraviolet-visible spectrometer; The drug analysis module is used to determine the physicochemical properties of the drug; The carrier selection module is used to recommend a matching carrier type based on the physicochemical properties of the drug; the matching carrier type is a carrier type that is compatible with the drug.

4. The ultrahigh-speed jet drug delivery device according to claim 1, characterized in that: The jet generating module further includes: Water cooling system for cooling; The control system is used to generate control instructions according to the direction and speed of the jet determined by the jet parameter setting module; the control instructions are used to control the spray angle and diameter of the nozzle.

5. The ultrahigh-speed jet drug delivery device according to claim 4, characterized in that: The control system further comprises: The electric valve is used to: control the switch of the flow of the drug solution; and control the flow rate of the drug solution by adjusting the opening of the electric valve.

6. The ultrahigh-speed jet drug delivery device according to claim 1, characterized in that: The ultra-high-speed jet drug delivery device further includes: a data processing module; The data processing module is used to: Obtain patients' real-time physiological data; The real-time physiological data and the distribution of the drug solution in the body are transmitted to a remote terminal and recorded.

7. The ultrahigh-speed jet drug delivery device according to claim 1, characterized in that: The ultra-high-speed jet drug delivery device further includes: a user interface; The user interface is used to: For users to set parameters; When an abnormal situation occurs, an alarm is issued; For users to view historical data; Provide users with operation manuals and help information.

8. The ultrahigh-speed jet drug delivery device according to claim 1, characterized in that: The shell of the ultra-high-speed jet drug delivery device is biocompatible.

Images