Purification device for amino acid preparation and method thereof

Abstract

The purification device comprises a base, a stirring barrel is fixedly connected to the upper portion of the base, a sliding plate is slidably connected to the interior of the stirring barrel, a second rotating block is fixedly connected to the upper portion of the sliding plate, the second rotating block is in direct transmission connection with a belt, and the belt is in transmission connection with a first rotating block; the first rotating block penetrates through the sliding plate, and the lower portion of the first rotating block is fixedly connected with one end of a connecting strip. One side of the connecting rack is in sliding connection with the limiting sleeve block, the other end of the limiting sleeve block sleeves the outer wall of the rotating rod, periodic reciprocating rotation in opposite directions of the first stirring frame and the second stirring frame can be realized in a crystallization refining link, and periodic up-and-down movement of the sliding plate is matched, so that uniform distribution of solute molecules is ensured; and local supersaturation abnormity is avoided, so that the crystal nucleus can be uniformly formed in the solution, the size is relatively consistent, and the structure is more complete and stable.

Description

Technical Field

[0001] The present invention relates to the technical field of amino acid extraction, and particularly relates to a purification device and method for amino acid preparation. Background Art

[0002] Amino acids, as the basic units of proteins, play an indispensable role in many fields. In the food industry, they are not only essential nutrients for the human body but also can be used as food additives to enhance the flavor and nutritional value of foods. Currently, the preparation methods of amino acids mainly include fermentation methods, hydrolysis methods, and chemical synthesis methods, etc. The fermentation method uses microorganisms to convert raw materials such as sugars and nitrogen sources into the required amino acids through their own metabolic activities under suitable culture media and culture conditions, and has the advantages of wide raw material sources and relatively mild production conditions.

[0003] In the fields of modern industrial production and scientific research, the purity of amino acids plays a decisive role in their application effects. With the rapid development of industries such as biotechnology, pharmaceuticals, food additives, and fine chemicals, the demand for high-purity amino acids shows a continuous growth trend, and the purification methods of amino acids mainly cover a variety of technical means. In the crystallization and refining process of amino acids, uneven stirring will cause many problems. In terms of crystal nucleus formation, there will be uneven distribution and poor quality, which may lead to different crystal nucleus sizes and defective structures. When the crystals grow, due to different solute diffusion rates, the growth rates are inconsistent, and there will also be serious agglomeration and caking. For example, tyrosine crystals may form hard lumps that enclose impurities, which has a great impact on subsequent operations, greatly increasing the separation difficulty. Fine crystals are easily lost with the mother liquor, and it is difficult to remove impurities from large crystals, and multiple cleaning and recrystallization are required, resulting in a decrease in the yield. Summary of the Invention

[0004] Aiming at the problems of related technologies, the present invention proposes a purification device for amino acid preparation to alleviate the above-mentioned technical problems existing in the prior art.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A purification device and method for preparing amino acids, including a base, a stirring cylinder is fixedly connected above the base, a sliding plate is slidably connected inside the stirring cylinder, a second rotating block is fixedly connected above the sliding plate, the second rotating block is directly driven to connect with a first rotating block, the lower part of the first rotating block is fixedly connected to one end of a connecting strip, the other end of the connecting strip is rotatably connected to an engaging rack, one side of the engaging rack is slidably connected to a limiting sleeve block, the other side of the engaging rack is meshed with an annular gear, the other end of the limiting sleeve block is sleeved on the outer wall of a rotating rod, the rotating rod is rotatably connected to the annular gear, the bottom of the annular gear is fixedly connected with a first stirring frame, the bottom of the annular gear is fixedly connected with a second connecting sleeve, the bottom of the second connecting sleeve is fixedly connected with an upper sleeve ring bevel gear, the upper sleeve ring bevel gear is rotatably connected to the rotating rod, the upper sleeve ring bevel gear is meshed with a first bevel gear, the first bevel gear is meshed with a lower sleeve ring bevel gear, the first bevel gear is rotatably connected to a connecting rod, the connecting rod is rotatably connected to a second bevel gear, the lower sleeve ring bevel gear is meshed with the second bevel gear, the bottom of the lower sleeve ring bevel gear is fixedly connected with a first connecting sleeve, and the bottom of the first connecting sleeve is fixedly connected with a second stirring frame.

[0007] The above technical solution further includes:

[0008] A sliding mechanism for driving the first stirring frame and the second stirring frame inside the stirring cylinder to move up and down is arranged above the base. The sliding mechanism includes a connecting frame arranged above the base, a groove for fixing a sliding groove plate is formed on the side of the connecting frame, the connecting frame is fixedly connected with the sliding groove plate, a motor is arranged on the side of the connecting frame, the output end of the motor is fixedly connected with a half gear, the half gear intermittently meshes with a first rack and a second rack arranged on the inner wall of an elliptical ring, the sliding groove plate is slidably connected with the elliptical ring, and a connecting block is fixedly connected above the elliptical ring. By setting the sliding mechanism, longitudinal stirring is realized, so as to prevent solute molecules remaining unevenly in the corners.

[0009] The second rotating block is drivingly connected with a belt, and the belt is drivingly connected with the first rotating block.

[0010] The sliding plate is rotatably connected with the rotating rod, a cutting groove is arranged on the side of the rotating rod, and the rotating rod is fixedly connected with the connecting rod.

[0011] The second connecting sleeve is sleeved on the outside of the rotating rod, the first connecting sleeve is sleeved on the outside of the rotating rod, and the lower sleeve ring bevel gear is rotatably connected with the rotating rod. By arranging the cutting groove on the side of the rotating rod, a stable fulcrum is provided for the rotation of the bevel gear, which is convenient for making full preparations for the rotation directions of the subsequent two groups of stirring frames.

[0012] The connecting block is fixedly connected with the side of the sliding plate.

[0013] At one end of the first stirring frame away from the rotating rod, multiple groups of stirring rods for stirring the inside of the stirring cylinder are provided. At one end of the second stirring frame away from the rotating rod, multiple groups of stirring rods are provided. By providing multiple groups of stirring rods outside the stirring frame, the stirring inside it can be made more uniform, thus facilitating the subsequent amino acid purification process.

[0014] A cover plate is rotatably connected to the side of the stirring cylinder. A control panel for controlling the rotation of the motor and the second rotating block is provided on the side of the stirring cylinder. By providing the control panel, the stirring speed inside it can be controlled to prevent the situation of too fast or too slow stirring speed.

[0015] A square groove for the up and down sliding of the connecting block is provided on the side of the stirring cylinder.

[0016] A method for using a purification device for amino acid preparation, characterized in that the specific steps are as follows:

[0017] S1: The second rotating block starts to rotate, which drives the first rotating block to rotate. The first rotating block drives the connecting bar to do circular motion. The connecting bar drives the connecting rack to perform periodic reciprocating rotation around itself. The connecting rack meshes with the ring gear, causing the ring gear to drive the first stirring frame to perform periodic reciprocating rotation. The first stirring frame drives the upper sleeve ring bevel gear to rotate through the second connecting sleeve. The upper sleeve ring bevel gear meshes with the first bevel gear, and further drives the lower sleeve ring bevel gear to perform periodic reciprocating rotation:

[0018] S2: The rotation direction of the second bevel gear is opposite to that of the first bevel gear. The lower sleeve ring bevel gear drives the second stirring frame to perform periodic reciprocating rotation through the first connecting sleeve. Finally, the first stirring frame and the second stirring frame form periodic reciprocating rotation in opposite directions, stirring the solution in the horizontal direction, promoting the uniform formation of crystal nuclei and the uniform distribution of solutes:

[0019] S3: Stop the operation of the second rotating block of the motor to end the stirring operation, and let the crystals naturally settle in the stirring cylinder for a period of time to initially separate the crystals from the mother liquor.

[0020] The present invention has the following beneficial effects:

[0021] 1. In the present invention, through the design of the stirring device, during the crystallization and refining process, the first stirring frame and the second stirring frame can perform periodic reciprocating rotation in opposite directions. At the same time, with the periodic up and down movement of the sliding plate, the solution in the stirring cylinder is fully and evenly stirred. This ensures the uniform distribution of solute molecules, avoids abnormal local supersaturation, so that crystal nuclei can be uniformly formed in the solution, with relatively consistent size and more complete and stable structure, laying a good foundation for the growth of high-quality crystals in the subsequent process.

[0022] 2. In the present invention, uniform stirring enables the rate of solute diffusion to crystal nuclei to remain relatively stable throughout the solution, avoiding the problem of inconsistent crystal growth rates caused by uneven stirring. The crystals can grow in a regular manner, effectively reducing the phenomenon of agglomeration and caking, reducing the possibility of amino acid crystals forming hard lumps and enclosing impurities, and improving the purity and quality of the crystals. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 is a schematic structural diagram of a purification device and method for amino acid preparation proposed by the present invention;

[0024] Figure 2 is a schematic bottom structure diagram of a purification device and method for amino acid preparation in the present invention;

[0025] Figure 3 is Figure 2 an enlarged schematic diagram at position A in

[0026] Figure 4 is a schematic side structure diagram of a purification device and method for amino acid preparation in the present invention;

[0027] Figure 5 is Figure 4 an enlarged schematic diagram at position B in

[0028] Figure 6 is a schematic partial structure diagram of a purification device and method for amino acid preparation in the present invention.

[0029] In the figure: 1, base; 2, stirring cylinder; 3, control panel; 4, connecting frame; 5, chute plate; 6, elliptical ring; 7, first rack; 8, second rack; 9, half gear; 10, connecting block; 11, sliding plate; 12, cover plate; 13, motor; 14, first rotating block; 15, second rotating block; 16, belt; 17, connecting bar; 18, connecting rack; 19, limiting sleeve block; 20, ring gear; 21, first stirring frame; 22, upper sleeve ring bevel gear; 23, first bevel gear; 24, second bevel gear; 25, lower sleeve ring bevel gear; 26, first connecting sleeve; 27, second stirring frame; 28, connecting rod; 29, rotating rod; 30, second connecting sleeve. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0030] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0031] Please refer toFigures 1-6 As shown in the figure, the present invention is a purification device for amino acid preparation, including a base 1. A stirring cylinder 2 is fixedly connected above the base 1. A sliding plate 11 is slidably connected inside the stirring cylinder 2. A second rotating block 15 is fixedly connected above the sliding plate 11. The second rotating block 15 is directly drivingly connected to a belt 16. The belt 16 is drivingly connected to a first rotating block 14. The first rotating block 14 penetrates through the sliding plate 11 and is fixedly connected to one end of a connecting strip 17 at the lower part. The other end of the connecting strip 17 is rotatably connected to an engaging rack 18. One side of the engaging rack 18 is slidably connected to a limiting sleeve block 19. The other end of the limiting sleeve block 19 is sleeved on the outer wall of a rotating rod 29. The other side of the engaging rack 18 is meshingly connected to an annular gear 20. The rotating rod 29 is fixedly connected to the annular gear 20. The annular gear 20 is fixedly connected to a first stirring frame 21.

[0032] A second connecting sleeve 30 is fixedly connected to the bottom of the annular gear 20. An upper sleeve ring bevel gear 22 is fixedly connected to the bottom of the second connecting sleeve 30. The upper sleeve ring bevel gear 22 is fixedly connected to the rotating rod 29. The upper sleeve ring bevel gear 22 is meshingly connected to a first bevel gear 23. The first bevel gear 23 is meshingly connected to a lower sleeve ring bevel gear 25. The first bevel gear 23 is fixedly connected to a connecting rod 28. The connecting rod 28 penetrates through the rotating rod 29 and is fixedly connected to a second bevel gear 24. The lower sleeve ring bevel gear 25 is meshingly connected to the second bevel gear 24. A first connecting sleeve 26 is fixedly connected to the bottom of the lower sleeve ring bevel gear 25. A second stirring frame 27 is fixedly connected to the bottom of the first connecting sleeve 26.

[0033] In one embodiment, for the above-mentioned sliding plate 11, the sliding plate 11 is rotatably connected to the rotating rod 29. A cutting groove is provided on the side of the rotating rod 29. The rotating rod 29 is fixedly connected to the connecting rod 28. By providing the cutting groove on the side of the rotating rod 29, a stable fulcrum is provided for the rotation of the bevel gear, facilitating the subsequent preparation for the rotation directions of the two groups of stirring frames.

[0034] In one embodiment, for the above-mentioned second connecting sleeve 30, the second connecting sleeve 30 is sleeved on the outside of the rotating rod 29. The first connecting sleeve 26 is sleeved on the outside of the rotating rod 29. The lower sleeve ring bevel gear 25 is rotatably connected to the rotating rod 29. By providing the second connecting sleeve 30 and the first connecting sleeve 26, the fixation of the stirring frame is realized, facilitating the subsequent stirring preparation.

[0035] In the crystallization and refining stage, the second rotating block 15 rotates to drive the first rotating block 14 to rotate. The rotation of the first rotating block 14 drives the connecting bar 17 to perform circular motion. One end of the connecting bar 17 drives the connecting rack 18 to perform periodic reciprocating rotation with itself as the center. The side of the connecting rack 18 without a rack performs periodic reciprocating rotation with the limit sleeve block 19. The side of the connecting rack 18 with a rack reciprocally meshes with the annular gear 20. The annular gear 20 drives the first stirring frame 21 to perform periodic reciprocating rotation. The first stirring frame 21 drives the upper sleeve ring bevel gear 22 to perform periodic reciprocating rotation through the second connecting sleeve 30. The upper sleeve ring bevel gear 22 meshes with the first bevel gear 23 to drive the lower sleeve ring bevel gear 25 to perform periodic reciprocating rotation. The second bevel gear 24 rotates in the opposite direction to the first bevel gear 23. The lower sleeve ring bevel gear 25 drives the second stirring frame 27 to perform periodic reciprocating rotation through the first connecting sleeve 26. Finally, the first stirring frame 21 and the second stirring frame 27 form periodic reciprocating rotations in opposite directions.

[0036] In one embodiment, a sliding mechanism for driving the first stirring frame 21 and the second stirring frame 27 inside the stirring cylinder 2 to move up and down is provided above the base 1. The sliding mechanism includes a connecting frame 4 provided above the base 1. A groove for fixing the chute plate 5 is formed in the side of the connecting frame 4, and the connecting frame 4 is fixedly connected to the chute plate 5. A motor 13 is provided on the side of the connecting frame 4. The output end of the motor 13 is fixedly connected to a half gear 9. An elliptical ring 6 is slidably arranged in the chute on the chute plate 5. The half gear 9 intermittently meshes with a first rack 7 and a second rack 8 provided on the inner wall of the elliptical ring 6. The chute plate 5 is slidably connected to the elliptical ring 6. An adapter block 10 is fixedly connected above the elliptical ring 6.

[0037] The adapter block 10 is fixedly connected to the side of the sliding plate 11. The side of the stirring cylinder 2 is rotatably connected to a cover plate 12. A control panel 3 for controlling the rotation of the motor 13 and the second rotating block 15 is provided on the side of the stirring cylinder 2. A square groove for the up and down sliding of the adapter block 10 is formed in the side of the stirring cylinder 2.

[0038] In one embodiment, for the above-mentioned first stirring frame 21, multiple groups of stirring rods for stirring the inside of the stirring cylinder 2 are provided at one end of the first stirring frame 21 away from the rotating rod 29. Multiple groups of stirring rods are provided at one end of the second stirring frame 27 away from the rotating rod 29. By providing multiple groups of stirring rods outside the stirring frame 21, the stirring inside it can be made more uniform, thus facilitating the subsequent amino acid purification process.

[0039] The motor 13 is controlled to rotate through the control panel 3. The output end of the motor 13 drives the half gear 9 to rotate. When the half gear 9 rotates, it first meshes with the first rack 7 on the inner wall of the elliptical ring 6. At this time, the meshing of the first rack 7 and the half gear 9 drives the elliptical ring 6 to move upward; the half gear 9 continues to rotate until the elliptical ring 6 rises to the highest point on the inner wall of the chute plate 5. Then, when the half gear 9 continues to rotate, the tooth block on its side will mesh with the second rack 8 on the inner wall of the elliptical ring 6, and then the second rack 8 drives the elliptical ring 6 to slide downward. The connecting block 10 fixed above the elliptical ring 6 is used to drive the sliding plate 11 to move up and down periodically, so as to stir the inside of the stirring cylinder 2 through the periodic reciprocating motion of the first stirring frame 21 and the second stirring frame 27 inside the stirring cylinder 2. Moreover, the elliptical ring 6 that moves up and down drives the sliding plate 11 to perform periodic reciprocating motion up and down inside the stirring cylinder 2, so as to make the uniformity of crystallization consistent.

[0040] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A purification device for preparing amino acids, characterized in that: The invention comprises a base (1), wherein a mixing drum (2) is fixedly connected to the top of the base (1), a sliding plate (11) is slidably connected to the inside of the mixing drum (2), a second rotating block (15) is fixedly connected to the top of the sliding plate (11), the second rotating block (15) is directly connected to a belt (16) in transmission, the belt is connected to a first rotating block (14) in transmission, the first rotating block (14) passes through the sliding plate 11 and is fixedly connected to one end of a connecting strip (17) at the bottom, the other end of the connecting strip (17) is rotatably connected to a connecting rack (18), one side of the connecting rack (18) is slidably connected to a limiting sleeve (19), the other end of the limiting sleeve (19) is sleeved on the outer wall of a rotating rod (29), the other side of the connecting rack (18) is meshingly connected to a ring gear (20), the rotating rod (29) is fixedly connected to the ring gear (20), the bottom of the ring gear (20) is The first bevel gear (21) is fixedly connected to the first stirring frame (21), the bottom of the annular gear (20) is fixedly connected to the second connecting sleeve (30), the bottom of the second connecting sleeve (30) is fixedly connected to the upper ring bevel gear (22), the upper ring bevel gear (22) is fixedly connected to the rotating rod (29), the upper ring bevel gear (22) is meshedly connected to the first bevel gear (23), the first bevel gear (23) is meshedly connected to the lower ring bevel gear (25), the first bevel gear (23) is fixedly connected to the connecting rod (28), the connecting rod (28) passes through the rotating rod (29) and is fixedly connected to the second bevel gear (24), the lower ring bevel gear (25) is meshedly connected to the second bevel gear (24), the bottom of the lower ring bevel gear (25) is fixedly connected to the first connecting sleeve (26), and the bottom of the first connecting sleeve (26) is fixedly connected to the second stirring frame (27); In the crystallization refining step, the second rotating block (15) rotates to drive the first rotating block (14) to rotate, and the rotation of the first rotating block (14) drives the connecting bar (17) to make a circular motion. One end of the connecting bar (17) drives the connecting rack (18) to perform periodic reciprocating rotation with itself as the center of the circle, and the side of the connecting rack (18) without the rack performs periodic reciprocating rotation with the limiting sleeve (19), and the side of the connecting rack (18) with the rack performs reciprocating meshing with the annular gear (20), and the annular gear (20) drives the first stirring frame (21) to perform periodic reciprocating rotation. The first stirring frame (21) is connected to the second connecting sleeve ( 30) drives the upper bevel ring gear (22) to perform periodic reciprocating rotation, the upper bevel ring gear (22) meshes with the first bevel gear (23) to drive the lower bevel ring gear (25) to perform periodic reciprocating rotation, the second bevel gear (24) rotates in the opposite direction to the first bevel gear (23), and the lower bevel ring gear (25) drives the second stirring frame (27) to perform periodic reciprocating rotation through the first connecting sleeve (26), and finally the first stirring frame (21) and the second stirring frame (27) form periodic reciprocating rotation in opposite directions, and the sliding plate (11) can be driven to move up and down periodically by the connecting block (10) in the sliding mechanism.

2. A purification device for preparing amino acids according to claim 1, characterized in that: A sliding mechanism for driving the first stirring frame (21) and the second stirring frame (27) inside the stirring drum (2) to move up and down is arranged above the base (1), and the sliding mechanism comprises a connecting frame (4) arranged above the base (1), a groove for fixing the slide plate (5) is opened on the side of the connecting frame (4), the connecting frame (4) is fixedly connected to the slide plate (5), a motor (13) is arranged on the side of the connecting frame (4), a half gear (9) is fixedly connected to the output end of the motor (13), an elliptical ring (6) is slidably arranged in the slide groove on the slide plate (5), the half gear (9) intermittently meshes with a first rack (7) and a second rack (8) arranged on the inner wall of the elliptical ring (6), the slide plate (5) is slidably connected to the elliptical ring (6), and a connecting block (10) is fixedly connected above the elliptical ring (6).

3. The amino acid preparation and purification device according to claim 1, characterized in that: The second rotating block (15) is drivingly connected to a belt (16), and the belt (16) is drivingly connected to the first rotating block (14).

4. The amino acid preparation and purification device according to claim 1, characterized in that: The sliding plate (11) is rotatably connected to a rotating rod (29), a cutting groove is arranged on a side of the rotating rod (29), and the rotating rod (29) is fixedly connected to a connecting rod (28).

5. The amino acid preparation and purification device according to claim 1, characterized in that: The second connecting sleeve (30) is sleeved on the outside of the rotating rod (29), the first connecting sleeve (26) is sleeved on the outside of the rotating rod (29), and the lower sleeve bevel gear (25) is rotatably connected to the rotating rod (29).

6. The amino acid preparation and purification device according to claim 2, characterized in that: The connecting block (10) is fixedly connected to the side of the sliding plate (11).

7. The amino acid preparation and purification device according to claim 1, characterized in that: The first stirring frame (21) is provided with a plurality of stirring rods at one end away from the rotating rod (29) for stirring the interior of the stirring drum (2), and the second stirring frame (27) is provided with a plurality of stirring rods at one end away from the rotating rod (29).

8. The amino acid preparation and purification device according to claim 1, characterized in that: The side of the mixing drum (2) is rotatably connected to a cover plate (12), and the side of the mixing drum (2) is provided with a control panel (3) for controlling the rotation of the motor (13) and the second rotating block (15).

9. The amino acid preparation and purification device according to claim 1, characterized in that: The side of the mixing drum (2) is provided with a square groove for the connecting block (10) to slide up and down.

10. The method for using the amino acid preparation and purification device according to claim 1, characterized in that: The specific steps are: S1: The second rotating block (15) starts to rotate, which drives the first rotating block (14) to rotate. The first rotating block (14) drives the connecting bar (17) to make a circular motion. The connecting bar (17) drives the connecting rack (18) to perform periodic reciprocating rotation with itself as the center of the circle. The connecting rack (18) meshes with the annular gear (20), so that the annular gear (20) drives the first stirring frame (21) to perform periodic reciprocating rotation. The first stirring frame (21) drives the upper ring bevel gear (22) to rotate through the second connecting sleeve (30). The upper ring bevel gear (22) meshes with the first bevel gear (23), thereby driving the lower ring bevel gear (25) to perform periodic reciprocating rotation: S2: The second bevel gear (24) rotates in the opposite direction to the first bevel gear (23), and the lower ring bevel gear (25) drives the second stirring frame (27) to perform periodic reciprocating rotation through the first connecting sleeve (26). Finally, the first stirring frame (21) and the second stirring frame (27) form periodic reciprocating rotation in opposite directions, stirring the solution in the horizontal direction, promoting uniform formation of crystal nuclei and uniform distribution of solutes: S3: Stop the operation of the second rotor (15) of the motor, end the stirring operation, and allow the crystals to settle naturally in the stirring barrel (2) for a period of time to achieve preliminary separation of the crystals from the mother liquor.

Images