Detection device for colloidal gold in-vitro diagnosis test paper

Abstract

The invention discloses a detection device for colloidal gold in-vitro diagnosis test paper, which comprises a detection box provided with a window for insertion of an in-vitro diagnosis test paper box; the detection support is arranged in the detection box, and the detection support is provided with a detection space for accommodating an in-vitro diagnosis test paper box; the monochromatic light emitter is arranged in the detection box, and the monochromatic light emitter faces the detection space; the photodiode is arranged in the detection box; and the detection module is arranged in the detection box, the detection module is connected with the photodiode, and the detection module is provided with a microprocessor. The absorbance of the test paper with different detection results is different, so that the intensity of light reflected to the photodiode by the test paper with different detection results is different, the resistance change of the photodiode is caused, the resistance change is converted into an electric signal by the detection module, and the detection result is read through the microprocessor. And the detection device is relatively low in cost, small in size and easy to transport.

Description

Technical Field

[0001] This application relates to the technical field of test strip detection, and particularly relates to a detection device for colloidal gold in vitro diagnostic test strips. Background Art

[0002] In vitro diagnostic test strip kits are tools for rapid detection, usually used for rapid detection in medical or home environments. They are usually portable and can provide preliminary results within a few minutes. Most existing in vitro diagnostic test strips are gold-labeled test strips.

[0003] In related technologies, the reading methods of in vitro diagnostic test strip kits include manual comparison reading, and there is a problem of inaccurate reading of detection results in manual comparison reading. There are also reading methods of in vitro diagnostic test strip kits that include reading methods based on machine vision, but the reading methods based on machine vision have high requirements for computing power and high costs.

[0004] Based on this, it is necessary to propose a detection device for colloidal gold in vitro diagnostic test strips, which can accurately detect the detection results of in vitro diagnostic test strip kits and has low costs, becoming an important technical problem to be solved urgently. Summary of the Invention

[0005] This application provides a detection device for colloidal gold in vitro diagnostic test strips, aiming to solve the problems of inaccurate reading of detection results or high requirements for computing power and high costs of reading methods based on machine vision in the prior art.

[0006] To achieve the above object, this application proposes a detection device for colloidal gold in vitro diagnostic test strips, including: a detection box, the detection box is provided with a window for inserting an in vitro diagnostic test strip kit; a detection support, the detection support is arranged in the detection box, and the detection support is provided with a detection space for accommodating the in vitro diagnostic test strip kit; a monochromatic light emitter, the monochromatic light emitter is arranged in the detection box, and the monochromatic light emitter faces the detection space; a photodiode, the photodiode is arranged in the detection box; a detection module, the detection module is arranged in the detection box, the detection module is connected to the photodiode, and the detection module is provided with a microprocessor.

[0007] In some embodiments, it further includes: a light absorption cover, the light absorption cover is arranged on the detection support, the light absorption cover is provided with a light inlet, the light inlet faces the monochromatic light emitter, the light absorption cover is provided with a light outlet, and the light outlet faces the photodiode; a stepped groove, the stepped groove is arranged on the light absorption cover adjacent to the light inlet; a filter, the filter is arranged in the stepped groove.

[0008] In some embodiments, it further includes: a heating wire, the heating wire is sleeved outside the detection module, the heating wire is electrically connected to the microprocessor, and an insulating coating is sleeved on the outer surface of the heating wire.

[0009] In some embodiments, it further includes: a deformation groove, which is arranged on both sides of the detection support facing the in vitro diagnostic test strip cassette; a shrapnel, which is arranged in the deformation groove, and the in vitro diagnostic test strip cassette is provided with a limiting groove.

[0010] In some embodiments, it further includes: a first arc surface, a first arc surface is arranged at one end of the shrapnel away from the deformation groove; a second arc surface, a second arc surface is arranged between the limiting groove and the in vitro diagnostic test strip cassette.

[0011] In some embodiments, it further includes: a fixing groove, which is arranged in the deformation groove, at least part of the shrapnel extends into the deformation groove, and an adhesive is arranged between the shrapnel and the fixing groove.

[0012] In some embodiments, it further includes: a light-shielding end plate, which is arranged on the in vitro diagnostic test strip cassette, and the cross-sectional area of the light-shielding end plate is larger than the cross-sectional area of the window.

[0013] In some embodiments, the detection box body includes: a bottom plate; a detection panel, which is arranged on the bottom plate; a back plate, which is arranged on the bottom plate; two side plates, the side plates are connected to the back plate, the side plates are connected to the detection panel, and the side plates are connected to the bottom plate; a top plate, the top plate is connected to the side plates, the top plate is connected to the back plate, and the top plate is connected to the detection panel.

[0014] In some embodiments, the detection box body includes: a plurality of first positioning grooves, which are arranged on the side plates, and the bottom plate, the detection panel and the bottom plate are all provided with first positioning protrusions adapted to the first positioning grooves; a plurality of second positioning grooves, which are arranged on the top plate, and the side plates are provided with positioning protrusions adapted to the second positioning grooves.

[0015] The technical solution of this application proposes a detection device for colloidal gold in vitro diagnostic test strips, including: a detection box provided with a window for inserting an in vitro diagnostic test strip cassette; a detection support disposed inside the detection box, the detection support having a detection space for accommodating the in vitro diagnostic test strip cassette; a monochromatic light emitter disposed in the detection box, the monochromatic light emitter facing the detection space; a photodiode disposed in the detection box; a detection module disposed in the detection box, the detection module connected to the photodiode, and the detection module having a microprocessor. According to the usage instructions of the colloidal gold in vitro diagnostic test strip, the tested in vitro diagnostic test strip cassette is inserted into the detection box through the window for testing the test strip result. At this time, the monochromatic light emitter is activated to emit monochromatic light. Part of the monochromatic light is absorbed by the test strip, and part is reflected to the photodiode. The absorbance of test strips with different detection results is different, so that the intensity of the light reflected from test strips with different detection results to the photodiode is different, causing a change in the resistance value of the photodiode. The detection module converts the above resistance value change into an electrical signal and reads the detection result through the microprocessor. By the above steps, the detection result of the colloidal gold in vitro diagnostic test strip can be read accurately. Moreover, the cost of the detection device is relatively low, the volume is small, and it is easy to transport. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings, where: Figure 1 is a schematic structural diagram of a detection device for colloidal gold in vitro diagnostic test strips according to an embodiment of the present application; Figure 2 is a rear view of a detection device for colloidal gold in vitro diagnostic test strips according to an embodiment of the present application; Figure 3 is a sectional view of a detection device for colloidal gold in vitro diagnostic test strips according to an embodiment of the present application; Figure 4 is Figure 3 a partial enlarged view of part A in Figure 5 is Figure 3 a partial enlarged view of part B in Figure 6 is another sectional view of a detection device for colloidal gold in vitro diagnostic test strips according to an embodiment of the present application; Figure 7 is Figure 6 a partial enlarged view of part C in Figure 8 This is a schematic structural diagram of an in vitro diagnostic test strip cassette according to an embodiment of the present application; In the figure: detection panel 1, window 2, second fastener 3, side plate 4, first positioning protrusion 5, second positioning protrusion 6, top plate 7, third positioning protrusion 8, first fastener 9, power supply inlet 10, back plate 11, fourth positioning protrusion 12, bottom plate 13, detection support 14, detection space 15, light source support plate 16, light absorption cover 17, stepped groove 18, detection area 19, filter 20, monochromatic light emitter 21, detection module 23, heating wire 24, deformation groove 26, elastic piece 27, first arc surface 271, fixing groove 28, in vitro diagnostic test strip cassette 29, light shielding end plate 291, limiting groove 292. Detailed implementation manners

[0017] Next, the technical solutions in the embodiments of the present application will be clearly and completely described with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

[0018] It should be noted that all directional indications (such as up, down, left, right, front, back...) in the embodiments of the present application are only used to explain the relative position relationship and movement conditions between components in a specific posture (as shown in the drawings). If the specific posture changes, the directional indications will also change accordingly.

[0019] It should also be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or there may be a centered element at the same time. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or there may be a centered element at the same time.

[0020] In addition, the descriptions involving "first", "second", etc. in the present application are only for descriptive purposes, and cannot be understood as indicating or implying their relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement them. When the combination of technical solutions results in contradictions or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the protection scope required by the present application.

[0021] Refer to Figure 1 、 Figure 2 and Figure 3As shown in the figure, the present application proposes a detection device for a colloidal gold in vitro diagnostic test strip, including: a detection box, the detection box is provided with a window 2 for inserting an in vitro diagnostic test strip cassette 29; a detection support 14, the detection support 14 is arranged inside the detection box, and the detection support 14 is provided with a detection space 15 for accommodating the in vitro diagnostic test strip cassette 29; a monochromatic light emitter 21, the monochromatic light emitter 21 is arranged in the detection box, and the monochromatic light emitter 21 faces the detection space 15; a photodiode, the photodiode is arranged in the detection box; a detection module 23, the detection module 23 is arranged in the detection box, the detection module 23 is connected to the photodiode, and the detection module 23 is provided with a microprocessor.

[0022] Among them, the detection box is the structural basis of the detection device for the in vitro diagnostic test strip, and other components in the detection device for the in vitro diagnostic test strip are directly or indirectly connected to the detection box. The detection support 14 is used to provide the detection space 15, so that the in vitro diagnostic test strip cassette 29 can be smoothly inserted into the detection box and stably placed in the detection box. The monochromatic light emitter 21 and the photodiode form the core components of the detection device for the in vitro diagnostic test strip. The monochromatic light emitter 21 emits monochromatic light and irradiates it onto the in vitro diagnostic test strip. Part of the light is absorbed by the test strip, and the other part of the light is reflected to the photodiode. According to the color development principle of the colloidal gold in vitro diagnostic test strip, the test strip will produce a red or pink reaction band after the reaction, and there is an obvious correlation between the concentration of the analyte and the color of the test strip. Test strips of different colors have different absorbances of monochromatic light, resulting in different light intensities received by the photodiode. The detection module 23 includes a detection circuit, the detection circuit is electrically connected to the photodiode, and emits an electrical signal as the resistance value of the photodiode changes. The detection module 23 also includes an IV conversion circuit and a voltage amplification circuit. After the electrical signal flows through the IV conversion circuit and the voltage amplification circuit, it enters the microprocessor, and the microprocessor outputs a detection result according to the electrical signal.

[0023] Specifically, according to the instructions for use of the colloidal gold in vitro diagnostic test strip, the tested in vitro diagnostic test strip cassette 29 is inserted into the detection box from the window 2 to detect the test strip result. At this time, the monochromatic light emitter 21 is activated to emit monochromatic light. Part of the monochromatic light is absorbed by the test strip, and part is reflected to the photodiode. The absorbances of test strips with different detection results are different, resulting in different light intensities of the test strips with different detection results reflected to the photodiode, causing changes in the resistance value of the photodiode. The detection module 23 converts the above resistance value changes into electrical signals and reads the detection results through the microprocessor. By the above steps, the detection results of the colloidal gold in vitro diagnostic test strip can be read accurately. Moreover, the cost of the detection device is relatively low, and the volume is small, making it easy to transport.

[0024] Among them, the monochromatic light emitter 21 is an LED. In this embodiment, the L525 type green LED is specifically selected as the light-emitting source. It has the characteristics of small volume, low power consumption, good monochromaticity, high brightness, low heat generation, etc., and has a long service life. According to the physical properties of light absorption, red substances have the largest absorption peak for green light. In this embodiment, single-color green light is selected as the detection light source, so as to maximize the detection accuracy.

[0025] Refer to Figure 1 , Figure 3 , Figure 4 and Figure 5 As shown in

[0026] Refer to Figure 3 and Figure 5 As shown in

[0027] In some embodiments, it further includes: an absorption hood 17. The absorption hood 17 is provided with a detection support 14. The absorption hood 17 is provided with a light inlet, and the light inlet faces the monochromatic light emitter 21. The absorption hood 17 is provided with a light outlet, and the light outlet faces the photodiode. The absorption hood 17 mainly functions as a enclosure. The detection support 14 is provided with an installation groove, and a part of the absorption hood 17 extends into the installation groove. The absorption hood 17, the in vitro diagnostic test strip cassette 29 and the detection support 14 jointly enclose a nearly closed detection area 19, and the detection of the test strip is carried out within this detection area 19, maximizing the avoidance of the influence of ambient light on the detection result and ensuring the detection accuracy. A stepped groove 18, the stepped groove 18 is arranged adjacent to the light inlet on the absorption hood 17. The stepped groove 18 is the structural basis for the filter 20 and is used to better place the filter 20. A filter 20, the filter 20 is arranged in the stepped groove 18. The filter 20 is used to filter non-monochromatic light to better ensure the accuracy of the detection result. Preferably, an adhesive is provided between the filter 20 and the stepped groove 18 for better fixing of the filter.

[0028] Refer to Figure 6 , Figure 7 andFigure 8 As shown, in some embodiments, it further includes: a deformation groove 26, which is arranged on both sides of the detection support 14 facing the in vitro diagnostic test strip cassette 29; the deformation groove 26 is used to provide a deformation space for the elastic piece 27, so that the elastic piece 27 can generate deformation. The elastic piece 27 is arranged in the deformation groove 26, and the in vitro diagnostic test strip cassette 29 is provided with a limiting groove 292. After the in vitro diagnostic test strip cassette 29 is inserted into the preset position, the elastic piece 27 abuts against the limiting groove 292, thereby limiting the position of the in vitro diagnostic test strip cassette 29 and preventing the in vitro diagnostic test strip cassette 29 from coming out.

[0029] Refer to Figure 6 、 Figure 7 and Figure 8 As shown, in some embodiments, it further includes: a first arc surface 271, which is arranged at one end of the elastic piece 27 away from the deformation groove 26; a second arc surface, and a second arc surface is arranged between the limiting groove 292 and the in vitro diagnostic test strip cassette 29. During the process of taking out the in vitro diagnostic test strip cassette 29, the in vitro diagnostic test strip cassette 29 can be forcibly pulled, so that the elastic piece 27 generates a large deformation, so that the elastic piece 27 comes out of the limiting groove 292. The settings of the first arc surface 271 and the second arc surface are both beneficial to the elastic piece 27 coming out of the limiting groove 292.

[0030] In this embodiment, the material of the elastic piece 27 is nylon, and preferably nylon 6. Nylon 6 is light in weight, good in toughness and good in wear resistance.

[0031] Refer to Figure 6 、 Figure 7 and Figure 8 As shown, in some embodiments, it further includes: a fixing groove 28, which is arranged in the deformation groove 26. The fixing groove 28 is the fixing basis for the elastic piece 27. At least part of the elastic piece 27 extends into the deformation groove 26, and an adhesive is arranged between the elastic piece 27 and the fixing groove 28. The elastic piece 27 is fixed in the deformation groove 26 by the adhesive.

[0032] Refer to Figure 8 As shown, in some embodiments, it further includes: a light-shielding end plate 291, which is arranged on the in vitro diagnostic test strip cassette 29, and the cross-sectional area of the light-shielding end plate 291 is larger than the cross-sectional area of the window 2. The light-shielding end plate 291 is used to prevent ambient light from entering and improve the accuracy of the detection result.

[0033] Refer to Figure 1 、 Figure 2 and Figure 3As shown, in some embodiments, the detection box body includes: a bottom plate 13; the bottom plate 13 is the structural foundation of the detection box body, and a detection support 14 is arranged on the bottom plate 13. A detection panel 1 is arranged on the bottom plate 13; a detection module 23 is arranged on the detection panel 1, and a control center is arranged on the detection panel 1 for manually controlling the detection. A back plate 11 is arranged on the bottom plate 13; a power supply access port 10 is arranged on the back plate 11. Two side plates 4, the side plates 4 are connected to the back plate 11, the side plates 4 are connected to the detection panel 1, and the side plates 4 are connected to the bottom plate 13; a top plate 7, the top plate 7 is connected to the side plates 4, the top plate 7 is connected to the back plate 11, and the top plate 7 is connected to the detection panel 1. A light source support plate 16 is arranged on the top plate 7, and a monochromatic light emitter 21 is arranged on the light source support plate 16.

[0034] Refer to Figure 1 、 Figure 2 and Figure 3 As shown, in some embodiments, the detection box body includes: a first fastener 9, the first fastener 9 is arranged between the top plate 7 and the back plate 11, and the first fastener 9 is arranged between the top plate 7 and the detection panel 1; a second fastener 3, the second fastener 3 is arranged between the side plate 4 and the detection panel 1, the second fastener 3 is arranged between the side plate 4 and the back plate 11, and the second fastener 3 is arranged between the side plate 4 and the bottom plate 13. The detachable connection of the detection box body is realized through the first fastener 9 and the second fastener 3.

[0035] Refer to Figure 1 、 Figure 2 and Figure 3 As shown, in some embodiments, the detection box body includes: a plurality of first positioning grooves, the plurality of first positioning grooves are arranged on the side plate 4, and first positioning protrusions 5 adapted to the first positioning grooves are arranged on the bottom plate 13, the detection panel 1 and the bottom plate 13; a plurality of second positioning grooves, the plurality of second positioning grooves are arranged on the top plate 7, and second positioning protrusions 6 adapted to the second positioning grooves are arranged on the side plate 4. A third positioning groove is arranged on the top plate 7, a third positioning protrusion 8 adapted to the third positioning groove is arranged on the back plate 11, a fourth positioning groove is arranged on the back plate 11, and a fourth positioning protrusion 12 adapted to the fourth positioning groove is arranged on the bottom plate 13. The installation of the box body is realized through the cooperation of the positioning grooves and the positioning protrusions, which is convenient for improving the assembly precision of the box body, thereby improving the detection precision.

[0036] The above are only partial or preferred embodiments of the present application. Whether in terms of text or drawings, the scope of protection of the present application cannot be limited thereby. Any equivalent structural transformation made under the overall concept of the present application by using the content of the specification and drawings of the present application, or directly / indirectly applied in other related technical fields, is included in the scope of protection of the present application.

Claims

1. A detection device for colloidal gold in vitro diagnostic test paper, characterized in that: include: A test box, the test box being provided with a window (2) for inserting an in vitro diagnostic test strip box (29); A detection support (14), the detection support (14) being arranged in the detection box, the detection support (14) being provided with a detection space (15) for accommodating an in vitro diagnostic test strip box (29); a monochromatic light emitter (21), the monochromatic light emitter (21) being arranged in the detection box, the monochromatic light emitter (21) facing the detection space (15); A photodiode, wherein the photodiode is disposed in the detection box; A detection module (23), the detection module (23) being arranged in the detection box, the detection module (23) being connected to the photodiode, and the detection module (23) being provided with a microprocessor.

2. The detection device for colloidal gold in vitro diagnostic test paper according to claim 1, characterized in that: Also includes: a light absorbing cover (17), the light absorbing cover (17) being arranged on the detection support (14), the light absorbing cover (17) being provided with a light inlet, the light inlet facing the monochromatic light emitter (21), and the light absorbing cover (17) being provided with a light outlet, the light outlet facing the photodiode; A stepped groove (18), the stepped groove (18) being arranged on the light absorbing cover (17) adjacent to the light inlet; A filter (20), wherein the filter (20) is arranged in the stepped groove (18).

3. The detection device for colloidal gold in vitro diagnostic test paper according to claim 1, characterized in that: Also includes: A heating wire (24), the heating wire (24) being sleeved on the outside of the detection module (23), the heating wire (24) being electrically connected to the microprocessor, and the outer surface of the heating wire (24) being sleeved with an insulating coating.

4. The detection device for colloidal gold in vitro diagnostic test paper according to claim 1, characterized in that: Also includes: Deformation grooves (26), the deformation grooves (26) being arranged on two sides of the detection support (14) facing the in vitro diagnostic test strip box (29); The spring piece (27) is arranged in the deformation groove (26), and the in vitro diagnostic test paper box (29) is provided with a limiting groove (292).

5. The detection device for colloidal gold in vitro diagnostic test paper according to claim 4, characterized in that: Also includes: A first arc-shaped surface (271), wherein the first arc-shaped surface (271) is provided at one end of the elastic sheet (27) away from the deformation groove (26); A second arc-shaped surface, wherein the limiting groove (292) is provided between the in vitro diagnostic test strip box (29).

6. The detection device for colloidal gold in vitro diagnostic test paper according to claim 4, characterized in that: Also includes: A fixing groove (28), wherein the fixing groove (28) is arranged in the deformation groove (26), the elastic sheet (27) at least partially extends into the deformation groove (26), and an adhesive is arranged between the elastic sheet (27) and the fixing groove (28).

7. The detection device for colloidal gold in vitro diagnostic test paper according to claim 1, characterized in that: Also includes: A light shielding end plate (291), the light shielding end plate (291) being arranged on the in vitro diagnostic test strip box (29), the cross-sectional area of ​​the light shielding end plate (291) being greater than the cross-sectional area of ​​the window (2).

8. The detection device for colloidal gold in vitro diagnostic test paper according to claim 1, characterized in that: The detection box comprises: Bottom plate (13); A detection panel (1), the detection panel (1) being arranged on the bottom plate (13); A back plate (11), the back plate (11) being arranged on the bottom plate (13); Two side panels (4), the side panels (4) being connected to the back panel (11), the side panels (4) being connected to the detection panel (1), and the side panels (4) being connected to the bottom panel (13); A top plate (7), the top plate (7) being connected to the side plate (4), the top plate (7) being connected to the back plate (11), and the top plate (7) being connected to the detection panel (1).

9. The detection device for colloidal gold in vitro diagnostic test paper according to claim 8, characterized in that: The detection box comprises: a first fastener (9), the first fastener (9) being arranged between the top plate (7) and the back plate (11), and the first fastener (9) being arranged between the top plate (7) and the detection panel (1); A second fastener (3), wherein the second fastener (3) is arranged between the side plate (4) and the detection panel (1), the second fastener (3) is arranged between the side plate (4) and the back plate (11), and the second fastener (3) is arranged between the side plate (4) and the bottom plate (13).

10. The detection device for colloidal gold in vitro diagnostic test paper according to claim 8, characterized in that: The detection box comprises: A plurality of first positioning grooves, wherein the plurality of first positioning grooves are arranged on the side plate (4), and the bottom plate (13), the detection panel (1) and the bottom plate (13) are all provided with first positioning protrusions (5) adapted to the first positioning grooves; A plurality of second positioning grooves are provided on the top plate (7), and the side plate (4) is provided with positioning protrusions adapted to fit the second positioning grooves.

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