Device for assisting in measuring blood pressure of mouse and using method thereof

Abstract

The invention discloses a device and method for assisting in measuring the blood pressure of a mouse. The device comprises a shading type outer shell, a shading type binding bag, a sensor containing cylinder and a blood pressure sensor. The shading type outer shell is of a barrel structure, a first clamping cover and a second clamping cover are detachably installed at openings in the two ends of the shading type outer shell respectively, an insertion hole used for inserting a medicine / gas delivery pipeline is formed in the first clamping cover, a rat tail penetrating hole is formed in the second clamping cover, and an optical fiber insertion hole is formed in the top of the shading type outer shell; the shading type binding bag is used for placing an experimental mouse, the shading type binding bag is arranged in the shading type outer shell, the tail of the experimental mouse penetrates out of the second clamping cover, the tail of the experimental mouse is sleeved with the sensor placing cylinder, and the blood pressure sensor is arranged in the sensor placing cylinder. The mouse blood pressure test under different experimental requirements can be met, experimental mice of different sizes can be bound and fixed, and the measurement success rate and precision are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of blood pressure regulation experimental devices, and particularly to a device for assisting in measuring the blood pressure of mice and a using method thereof. Background Art

[0002] Due to the high genetic similarity with humans, rodent animals are widely used in research and teaching in fields such as biology, medicine, and veterinary medicine. Mice have advantages such as low breeding cost, high reproduction rate, high genetic purity, and metabolic and physiological and pathological characteristics close to humans, and are commonly used animal models in experiments. However, existing blood pressure measurement devices for experimental mice have many deficiencies. For example, they cannot accurately match the individual differences of mice, are prone to loosening after long-term use, and cannot achieve external intervention during the blood pressure measurement process. At the same time, the excreta of mice during the experiment may contaminate the device, thereby affecting the subsequent experimental accuracy. Therefore, it is urgent to improve the existing device. Summary of the Invention

[0003] The purpose of the present invention is to provide a device for assisting in measuring the blood pressure of mice and a using method thereof to solve the problems raised in the above background art.

[0004] To achieve the above purpose, the present invention provides the following technical solutions:

[0005] A device for assisting in measuring the blood pressure of mice includes: a light-shielding outer housing, a light-shielding restraint bag, a sensor placement cylinder, and a blood pressure sensor;

[0006] The light-shielding outer housing has a cylindrical structure, and first and second covers are detachably installed at the two open ends of the cylindrical structure respectively. An insertion hole for inserting a drug / gas delivery pipe is provided on the first cover, a mouse tail perforation is provided on the second cover, and an optical fiber jack for inserting an optical fiber is provided at the top of the light-shielding outer housing;

[0007] The light-shielding restraint bag is used for placing an experimental mouse, and the light-shielding restraint bag is arranged inside the light-shielding outer housing. The two ends of the light-shielding restraint bag are open, and the tail of the experimental mouse passes through the opening of the light-shielding restraint bag and the mouse tail perforation and penetrates out of the second cover. The sensor placement cylinder is sleeved on the tail of the experimental mouse, the blood pressure sensor is arranged inside the sensor placement cylinder, and the blood pressure sensor is connected to an external detection terminal.

[0008] In some embodiments, the light-shielding restraint bag includes a restraint band body and elastic restraint bands installed at the two open ends of the restraint band body.

[0009] In some embodiments, the device further includes an annular flexible metal band, and the annular flexible metal band is sleeved on the outer periphery of the light-shielding restraint bag.

[0010] In some of these embodiments, the color of the light-shielding outer housing is black, and a movable cover is further installed on the top of the light-shielding outer housing.

[0011] In some of these embodiments, the sensor placement cylinder is detachably connected to the second capping.

[0012] In some of these embodiments, a heating strip is further fixed to the tail of the experimental mouse.

[0013] In some of these embodiments, a plurality of ventilation holes are evenly distributed on the surface of the light-shielding restraint bag.

[0014] In some of these embodiments, the light-shielding restraint bag is made of a waterproof and antibacterial textile fabric.

[0015] In addition, the present invention also discloses a method for using the above-described device for assisting in measuring the blood pressure of a mouse, and the method for using includes the following steps:

[0016] After placing the experimental mouse in the light-shielding restraint bag, the head and tail of the experimental mouse are respectively passed through both ends of the light-shielding restraint bag, and the experimental mouse is fixed from the outside of the light-shielding restraint bag;

[0017] After the entire light-shielding restraint bag is placed in the light-shielding outer housing, the first capping and the second capping are respectively installed at the two open ends of the light-shielding outer housing, and the mouse head of the experimental mouse faces the insertion hole, and the tail of the experimental mouse passes through the mouse tail perforation and is outside the light-shielding outer housing;

[0018] The sensor placement cylinder is sleeved on the tail of the experimental mouse and fixed, and the blood pressure sensor is installed in the sensor placement cylinder;

[0019] The blood pressure of the experimental mouse is collected in real time by the blood pressure sensor and fed back to an external detection terminal.

[0020] In some of these embodiments, the method for using further includes: during the experiment, according to different experimental requirements, the optical fiber is inserted into the light-shielding outer housing from the optical fiber jack to perform central or peripheral system intervention on the experimental mouse, and / or drugs / gases are delivered to the experimental mouse through a drug / gas delivery pipe at the insertion hole of the first capping.

[0021] Compared with the prior art, the present invention has at least one of the following advantages or beneficial effects:

[0022] First, by providing an insertion hole for inserting a drug / gas delivery pipe and an optical fiber socket for inserting an optical fiber, the present invention performs diversified intervention operations while measuring blood pressure, thereby meeting different experimental requirements and improving the flexibility of the experiment.

[0023] Second, the structure of the present invention is reasonably designed and easy to operate. It can adapt to mice of different sizes, reduce the discomfort of mice, improve the measurement accuracy, and the light-shielding restraint bag can be conveniently replaced to avoid the residual smell of the previous experimental mice affecting the next experimental mice, ensuring the accuracy of experimental data.

[0024] Third, the light-shielding restraint bag of the present invention is made of waterproof and antibacterial textile material, with a soft texture and easy to replace, avoiding the experimental environment being contaminated by urine and feces, and the restraint tightness can be adjusted at any time to create suitable experimental conditions, ensuring the reliability and consistency of data, and improving the experimental efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] By reading the following detailed description of non-limiting embodiments with reference to the accompanying drawings, the present invention and its features, shape, and advantages will become more obvious. The same reference numerals indicate the same parts in all the drawings. The drawings are not drawn to scale, and the emphasis is on showing the gist of the present invention.

[0026] Figure 1 It is a schematic structural diagram of the device for assisting in measuring the blood pressure of mice in the embodiment of the present invention;

[0027] Figure 2 It is a schematic structural diagram of the light-shielding restraint bag in the embodiment of the present invention;

[0028] Figure 3 It is a schematic installation diagram of the flexible metal band in the embodiment of the present invention;

[0029] Figure 4 It is a schematic diagram of the usage method of the device for assisting in measuring the blood pressure of mice in the embodiment of the present invention;

[0030] In the figure: 1. Light-shielding outer housing; 2. Light-shielding restraint bag; 3. First cover; 4. Optical fiber jack; 5. Experimental mouse; 6. Second cover; 7. Light-shielding restraint bag body; 8. Mouse head exit; 9. Mouse tail exit; 10. First elastic restraint band; 11. Second elastic restraint band; 12. Ring-shaped flexible metal band; 13. Movable cover; 14. Blood pressure sensor; 15. Tail; 16. Ventilation hole; 17. Insertion hole; 18. Mouse tail perforation; 19. Sensor placement cylinder; 20. Heating strip. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0031] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0032] It should be noted that when an element is referred to as "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly disposed on the other element; when an element is referred to as "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

[0033] It should be understood that the orientation or positional relationship indicated by terms such as "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present application.

[0034] In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of the present application, the meaning of "a plurality of" or "several" is two or more, unless otherwise specifically defined.

[0035] It should be noted that the structures, proportions, sizes, etc. shown in the drawings of this specification are only used to cooperate with the content disclosed in the specification for those familiar with this technology to understand and read, and are not used to limit the conditions for the implementation of the present application. Therefore, they do not have technical essential significance. Any modification of the structure, change in the proportional relationship, or adjustment of the size, without affecting the efficacy that the present application can produce and the purpose that can be achieved, should still fall within the scope that the technical content disclosed in the present application can cover. At the same time, the terms such as "upper", "lower", "left", "right", "middle", and "one" cited in this specification are only for the convenience of clear narration and are not used to limit the scope for the implementation of the present application. The change or adjustment of their relative relationship, without substantial change in the technical content, should also be regarded as the scope for the implementation of the present application.

[0036] Embodiment 1:

[0037] Please refer to Figures 1 to 3As shown in the figure, the present invention discloses a device for assisting in measuring the blood pressure of mice. Specifically, the device includes a light-shielding outer housing 1, a light-shielding restraint bag 2, a sensor placement cylinder 19, and a blood pressure sensor 14. The light-shielding outer housing 1 is in a cylindrical structure, and first and second covers 3 and 6 are detachably installed at the two open ends of the cylindrical structure respectively. An insertion hole 17 for inserting a drug / gas delivery pipe is provided on the first cover 3, and a mouse tail perforation 18 is provided on the second cover 6. A fiber optic jack 17 for inserting an optical fiber (which can be an optical fiber patch cord) is provided at the top of the light-shielding outer housing 1. The light-shielding restraint bag 2 is used to place the experimental mouse 5, and the light-shielding restraint bag 2 is arranged inside the light-shielding outer housing 1. The two ends of the light-shielding restraint bag 2 are open, and the tail 15 of the experimental mouse 5 passes through the opening of the light-shielding restraint bag 2 and the mouse tail perforation 18 and extends out of the second cover 6 and is arranged outside the light-shielding outer housing 1. The sensor placement cylinder 19 is sleeved on the tail 15 of the experimental mouse 5, and the blood pressure sensor 14 is arranged inside the sensor placement cylinder 19, and the blood pressure sensor 14 is connected to an external detection terminal. A heating strip 20 is also fixed to the bottom of the tail 15 of the experimental mouse 5 to heat the mouse tail.

[0038] In an embodiment of the present invention, the above-mentioned light-shielding restraint bag 2 includes a light-shielding restraint bag body 7. Mouse head outlets 8 and mouse tail outlets 9 are respectively provided at the two ends of the light-shielding restraint bag body 7. A first elastic restraint band 10 is installed at the mouse head outlet 8, and a second elastic restraint band 11 is installed at the mouse tail outlet 9. The elastic restraint bands can be used to tighten or open the mouse head outlet 8 and the mouse tail outlet 9, so as to facilitate tightening the mouse head outlet 8 and the mouse tail outlet 9 after the experimental mouse 5 is placed, and also facilitate opening. A number of air holes 16 are evenly distributed on the surface of the light-shielding restraint bag body 7 for ventilation. The light-shielding restraint bag body 7 is made of a waterproof and antibacterial textile fabric. The light-shielding restraint bag adopted in the present invention uses a waterproof textile fabric, which is soft in texture, convenient to replace, can prevent the leakage of urine and feces of rodents from polluting the experimental environment. In addition, the tightness of the restraint on rodents can be adjusted at any time, which can create good experimental conditions, ensure the accuracy of experimental data, and improve the operation efficiency of experimental research.

[0039] In an embodiment of the present invention, the above-mentioned device further includes an annular flexible metal band 12. After the experimental mouse 5 is loaded into the light-shielding restraint bag 2, only need to annularly sleeve the annular flexible metal band 12 around the outer periphery of the middle part of the light-shielding restraint bag body 7 to fix the experimental mouse 5 (the annular flexible metal band 12 is similar to the principle of a rubber band). The color of the above-mentioned light-shielding outer housing 1 is black, and a movable cover 13 is also installed at the top of the above-mentioned light-shielding outer housing 1 to facilitate observing the experimental mouse 5 and facilitating the access of cables, etc. when needed. The above-mentioned sensor placement cylinder 19 can be detachably connected to the second cover 6 by means of tape or the like to prevent the sensor placement cylinder 19 from loosening.

[0040] Example 2:

[0041] As Figure 4 shown, the present invention also discloses a method for using the device for assisting in measuring the blood pressure of mice in the first embodiment above. Specifically, the method for using includes the following steps:

[0042] Step S1: After placing the experimental mouse in the light-shielding restraint bag, pass the head and tail of the experimental mouse through the openings at both ends of the light-shielding restraint bag respectively (the head of the experimental mouse passes through the mouse head outlet, and the tail of the experimental mouse passes through the mouse tail outlet), and fix the experimental mouse from the outside of the light-shielding restraint bag by means of a circular flexible metal band.

[0043] Step S2: After placing the whole light-shielding restraint bag into the light-shielding housing body, install the first cover and the second cover at the openings at both ends of the light-shielding housing body respectively, and the mouse head of the experimental mouse faces the insertion hole, and the tail of the experimental mouse passes through the mouse tail perforation and is outside the light-shielding housing body.

[0044] Step S3: Sleeve the sensor placement cylinder on the tail of the experimental mouse and fix the sensor placement cylinder on the second cover by means of tape, and install the blood pressure sensor in the sensor placement cylinder.

[0045] Step S4: During the experiment, according to different experimental requirements, the fiber optic jumper can be inserted into the light-shielding housing body from the fiber optic jack to perform central or peripheral system intervention on the experimental mouse, and / or a drug / gas delivery pipe at the insertion hole of the first cover to deliver drugs / gases to the experimental mouse through the drug / gas delivery pipe, and the blood pressure of the experimental mouse is collected in real time by the blood pressure sensor and fed back to the external detection terminal for the experimenter to analyze.

[0046] It is not difficult to find that this embodiment is a method embodiment corresponding to the embodiment of the device for assisting in measuring the blood pressure of mice above, and this embodiment can be implemented in cooperation with the embodiment of the device for assisting in measuring the blood pressure of mice above. The relevant technical details mentioned in the embodiment of the device for assisting in measuring the blood pressure of mice above are still valid in this embodiment, and in order to reduce repetition, they will not be elaborated here. Correspondingly, the relevant technical details mentioned in this embodiment can also be applied to the embodiment of the device for assisting in measuring the blood pressure of mice above.

[0047] In summary, the present invention has a novel structural design and is convenient to operate. It can meet the blood pressure tests of mice under different experimental requirements, restrain and fix experimental mice of different sizes, reduce the discomfort of experimental mice, improve the measurement success rate and accuracy. In addition, it is also convenient to replace the light-shielding restraint bag, reduce the influence of the dirt in the light-shielding restraint bag on the next experimental mouse, and improve the experimental effect.

[0048] The circuits, electronic components, and modules involved in the present invention are all prior arts, which can be fully implemented by those skilled in the art without further elaboration. The content protected by the present invention does not involve improvements to software and methods either.

[0049] It should also be noted that in this specification, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variation thereof is intended to cover non-exclusive inclusion, such that a process, method, article or device comprising a series of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising an..." does not exclude the presence of additional identical elements in the process, method, article or device comprising the element.

Claims

1. A device for assisting in measuring blood pressure of mice, characterized in that: include: A light-shielding outer shell, a light-shielding restraint bag, a sensor placement tube, and a blood pressure sensor; The light-shielding outer shell is a cylindrical structure, and a first card cover and a second card cover are detachably mounted at the openings at both ends of the cylindrical structure, the first card cover is provided with an insertion hole for inserting a drug / gas delivery pipeline, the second card cover is provided with a rat-tail perforation, and the top of the light-shielding outer shell is provided with an optical fiber jack for inserting an optical fiber; The light-shielding restraint bag is used to place experimental mice, and the light-shielding restraint bag is arranged in the light-shielding outer shell. Both ends of the light-shielding restraint bag are open, and the tail of the experimental mouse passes through the opening of the light-shielding restraint bag and the mouse tail hole to pass through the second card cover, the sensor placement tube is sleeved on the tail of the experimental mouse, the blood pressure sensor is arranged in the sensor placement tube, and the blood pressure sensor is connected to the external detection terminal.

2. The device for assisting in measuring blood pressure of mice according to claim 1, characterized in that: The light-shielding restraint bag comprises a restraint belt body and elastic restraint belts installed at openings at both ends of the restraint belt body.

3. The device for assisting in measuring blood pressure of mice according to claim 1, characterized in that: The device further comprises an endless flexible metal belt, and the endless flexible metal belt is sleeved on the outer circumference of the light-shielding restraint bag.

4. The device for assisting in measuring blood pressure of mice according to claim 1, characterized in that: The color of the light-shielding outer shell is black, and a movable cover is installed on the top of the light-shielding outer shell.

5. The device for assisting in measuring blood pressure of mice according to claim 1, characterized in that: The sensor placement tube is detachably connected to the second card cover.

6. The device for assisting in measuring blood pressure of mice according to claim 1, characterized in that: A heating strip is also fixed on the tail of the experimental mouse.

7. The device for assisting in measuring blood pressure of mice according to claim 1, characterized in that: The surface of the light-shielding restraint bag is uniformly provided with a plurality of air holes.

8. The device for assisting in measuring blood pressure of mice according to claim 1, characterized in that: The light-shielding restraint bag is made of waterproof and antibacterial textile fabric.

9. A method for using the device for assisting in measuring blood pressure of mice as claimed in any one of claims 1 to 8, characterized in that: The method of use comprises the following steps: After placing the experimental mouse in the light-shielding restraint bag, the head and tail of the experimental mouse are passed through the two ends of the light-shielding restraint bag respectively, and the experimental mouse is fixed from the outside of the light-shielding restraint bag; After the light-shielding restraint bag is placed in its entirety into the light-shielding outer shell, the first card cover and the second card cover are respectively installed at the openings at both ends of the light-shielding outer shell, with the head of the experimental mouse facing the insertion hole, and the tail of the experimental mouse passing through the tail through-hole and being outside the light-shielding outer shell; The sensor placement tube is placed on the tail of the experimental mouse and fixed, and the blood pressure sensor is installed in the sensor placement tube; The blood pressure of experimental mice is collected in real time through a blood pressure sensor and fed back to an external detection terminal.

10. The method for using the device for assisting in measuring blood pressure of mice according to claim 9, characterized in that: The method of use also includes: during the experiment, according to different experimental requirements, inserting the optical fiber from the optical fiber jack into the light-shielding outer shell to intervene in the central or peripheral system of the experimental mouse, and / or delivering drugs / gas to the experimental mouse through the drug / gas delivery pipeline in the insertion hole of the first card cover.

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