Gastrointestinal tumor cell collector and collection method

Abstract

The invention relates to the technical field of cell sampling or living tissue section inspection, in particular to a digestive tract tumor cell collector and a collection method. The collector comprises a device body, the device body at least comprises a connecting piece and an external pipe which are connected in sequence, the external pipe is detachably connected with the connecting piece, the connecting piece comprises a connecting table and a main shaft, and the main shaft penetrates through the connecting table and is connected with a sampling assembly; a sliding groove is formed in the connecting table, a feedback control assembly is slidably connected into the sliding groove, the feedback control assembly is electrically connected with the sampling assembly and connected with the main shaft through a wire, and the feedback control assembly feeds back and adjusts the main shaft. The problem that in the prior art, due to the fact that the convenience of the collection process is ignored, the operation time is too long, and a patient feels seriously uncomfortable is solved.

Description

Technical Field

[0001] This application relates to the technical field of cell sampling or biopsy, and more particularly, to a digestive tract tumor cell collector and a collection method thereof. Background Art

[0002] Due to the use of chemical fertilizers, pesticides, feeds, additives, etc. in today's food industry, health problems caused by food are becoming increasingly serious. Digestive tract tumors are a highly prevalent disease. When diagnosing and treating digestive tract tumors, it is necessary to collect digestive tract tumor cells for laboratory analysis, and this requires the use of a digestive tract tumor cell collector.

[0003] In the prior art, there is a Chinese utility model patent with a publication date of April 30, 2019, a publication number of CN208799252U, and a name of a digestive tract tumor cell collector. It discloses an upper collector, a middle collector, and a lower collector. An elastic membrane is wrapped around the outer sides of the middle collector and the lower collector. The elastic membrane is formed by stretching a rectangular membrane and then winding it around the outer side of the middle collector or the lower collector and then detachably connecting two sides together. Although this structure can achieve cell collection, the convenience during the collection process still needs to be improved, so as to avoid serious discomfort of the patient due to too long operation time. Summary of the Invention

[0004] In view of this, the purpose of the present invention is to provide a digestive tract tumor cell collector and a collection method thereof, which optimize the collection process of digestive tract tumor cells and solve the problem in the prior art that due to the neglect of the convenience of the collection process, the operation time is too long, resulting in serious discomfort of the patient.

[0005] According to one aspect of the present application, there is provided a digestive tract tumor cell collector, specifically providing a collector for quickly realizing the collection of digestive tract tumor cell samples, including: a device body, the device body at least includes a connecting member and an outer connecting pipe connected in sequence, the outer connecting pipe is detachably connected to the connecting member, the connecting member includes a connecting platform and a main shaft, the main shaft passes through the connecting platform and is connected with a sampling assembly; a sliding groove is opened on the connecting platform, and a feedback control assembly is slidably connected in the sliding groove. The feedback control assembly is electrically connected to the sampling assembly and is connected to the main shaft through a wire, and the feedback control assembly feedback-adjusts the main shaft.

[0006] In some embodiments, the sampling assembly at least includes a scraping blade, a connecting column, and a pressure sensor. One end of the connecting column is detachably connected to the scraping blade, and the other end is connected to the main shaft; pressure sensors are arranged on the scraping blade, and the pressure sensors are data-connected to the feedback control assembly. When the cells come into contact with the surface of the pressure sensors after collection, the pressure sensors will transmit pressure contact information to the feedback control assembly.

[0007] In some embodiments, the feedback control component at least includes a main control center, a drive shaft, a drive disk, a connecting rod, a connecting sleeve, and a brake block arranged from top to bottom. Among them, the main control center is data-connected to the drive shaft, the drive shaft is fixedly connected to the drive disk, the drive disk is fixedly connected to the connecting rod, the connecting rod is fixedly connected to the connecting sleeve, and the connecting sleeve is fixedly connected to the brake block.

[0008] In some embodiments, a first camera, a second camera, and a third camera are externally connected to the connection platform. The first camera is arranged at an interval from the second camera, the second camera is arranged at an interval from the third camera, and the third camera is arranged at an interval from the first camera.

[0009] In some embodiments, a first light source, a second light source, and a third light source are electrically connected to the connection platform. The first light source is arranged beside the first camera, the second light source is arranged beside the second camera, and the third light source is arranged beside the third camera.

[0010] In some embodiments, an external sleeve is sleeved on the outer periphery of the connecting column. At least one circle of mesh holes for blocking foreign objects and ensuring air circulation is arranged at intervals on the peripheral surface of the external sleeve.

[0011] In some embodiments, a first control unit and a second control unit connected by data are configured in the main control center. Among them, the first control unit is electrically connected to the main shaft and controls the rotation of the main shaft, and the second control unit controls the brake block to execute the locking of the main shaft drive based on the pressing information of the pressure contact sensor.

[0012] In some embodiments, a pressing and locking mechanism is connected between the main shaft and the brake block.

[0013] According to another aspect of the present application, a method for collecting gastrointestinal tumor cells is provided, including:

[0014] Step 1. Connect the external connecting pipe to form the collector body;

[0015] Step 2. Manually send the collector body to the affected area of the digestive tract;

[0016] Step 3. Control the feedback control component and the sampling component to operate;

[0017] Step 4. Stop sampling after obtaining tumor cells.

[0018] The technical solution of this application has at least the following advantages and beneficial effects: Through the sampling component and the feedback control component, this application quickly realizes the collection of tumor cell samples in the digestive tract, optimizes the collection steps, greatly improves the convenience during the collection process, reduces the pain of patients, and at the same time, in cooperation with the main control center and the pressure sensor, realizes the precise control of the sample collection volume and the precise regulation of the collection operation process. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic structural diagram of the collector provided by this application;

[0020] Figure 2 It is a schematic structural diagram of the connecting piece in the collector provided by this application;

[0021] Figure 3 It is another schematic structural diagram of the connecting piece in the collector provided by this application;

[0022] Figure 4 It is a bottom view of the connecting table in the collector provided by this application;

[0023] Figure 5 It is yet another schematic structural diagram of the connecting piece in the collector provided by this application.

[0024] In the figure: 1 - connecting piece; 2 - outer connecting pipe; 3 - connecting table; 4 - main shaft; 5 - sliding groove; 6 - driving shaft; 7 - scraping blade; 8 - connecting column; 9 - pressure sensor; 10 - main control center; 11 - driving disc; 12 - connecting rod; 13 - connecting sleeve; 14 - brake block; 15 - first camera; 16 - second camera; 17 - third camera; 18 - wire; 19 - first light source; 20 - second light source; 21 - third light source; 22 - outer connecting sleeve; 23 - with mesh holes. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0025] Next, the technical solutions in the embodiments of this application will be clearly and completely described in conjunction with the drawings in the embodiments of this application. Obviously, the described embodiments are only a part of the embodiments of this application, rather than all the embodiments. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of this application.

[0026] Embodiment

[0027] Please refer to Figures 1 - 5The present application provides a digestive tract tumor cell collector, including: a device body, the device body at least includes a connector 1 and an external tube 2 connected in sequence, the external tube 2 is detachably connected to the connector 1, the connector 1 includes a connecting platform 3 and a main shaft 4, the main shaft 4 passes through the connecting platform 3 and is connected to a sampling component; a slide groove 5 is opened on the connecting platform 3, a feedback control component is slidably connected in the slide groove 5, the feedback control component is electrically connected to the sampling component and is connected to the main shaft 4 through a wire 18, and the feedback control component feedback adjusts the main shaft 4.

[0028] It is worth noting that in this embodiment, a connector 1 and an external tube 2 are provided, and the connector 1 is connected by the external tube 2, so that the connector 1 can be sent into the body or pulled out of the body. The detachable connection facilitates the installation and removal between the connector 1 and the external tube 2. When the connector 1 or the external tube 2 needs to be cleaned, it can be cleaned separately to avoid the residue of bacteria or pollutants that cause the entire device to be unable to be used normally, and to avoid infection or secondary injury to the patient. In detail, the connector 1 includes a connecting platform 3 and a main shaft 4 that are connected to each other. By controlling the rotation of the main shaft 4, the sampling component is driven to rotate. The sample is collected during the rotation of the sampling component. After the sample is collected, that is, the sampling component senses the sample attachment and receives the specified pressure signal, the sampling component will transmit the collection signal or pressure signal to the specified receiving end, and then control the feedback control component to start working. The feedback control component is driven and moves along the slide 5. The feedback control component feedback adjusts the main shaft 4, and then controls the main shaft 4 to lock, that is, the main shaft 4 is not allowed to rotate. At this time, the sampling component stops acquiring the sample, and the operator draws out the sampler body to complete the sampling.

[0029] This embodiment uses a sampling component and a feedback control component to quickly collect tumor cell samples in the digestive tract, optimizes the collection steps, greatly improves the convenience of the collection process, minimizes the duration of the operation process, reduces the patient's pain, reduces the patient's discomfort, and solves the problem in the prior art that the convenience of the collection process is ignored, resulting in a long operation time and severe discomfort to the patient.

[0030] Furthermore, the sampling component at least includes a scraper 7, a connecting column 8 and a pressure touch sensor 9. One end of the connecting column 8 is detachably connected to the scraper 7, and the other end is connected to the main shaft 4. A pressure touch sensor 9 is arranged on the scraper 7, and the pressure touch sensor 9 is data-connected to the feedback control component. When the cells are collected and contact the surface of the pressure touch sensor 9, the pressure touch sensor 9 will transmit the pressure touch information to the feedback control component.

[0031] In this embodiment, a scraping blade 7, a connecting column 8, and a pressure sensor 9 are provided. The rotation of the scraping blade 7 is used to adhere to and collect tumor cell samples in the digestive tract. The connecting column 8 is used for connection, and the rotation of the connecting column 8 is driven to drive the rotation of the scraping blade 7, thereby completing sample collection. By setting the pressure sensor 9 on the scraping blade 7, it is possible to effectively and quickly determine whether the sample is in contact with the scraping blade 7, minimize the ineffective operation process, and further effectively alleviate the discomfort of the patient. Specifically, the pressure sensor 9 is connected to the feedback control component for data transmission. When the cell sample contacts the surface of the pressure sensor 9 after collection, the pressure sensor 9 will transmit the pressure contact information to the feedback control component, enabling the feedback control component to quickly control the main shaft 4 and shortening the entire sample collection time.

[0032] Preferably, the scraping blade 7 is spiral and wound around the connecting column 8, enabling the scraping blade 7 to form a spiral working state during the rotation of the connecting column 8. Due to the extrusion force of the sample in front on the sample behind, the sample in contact with the end of the scraping blade 7 continuously moves upward and is collected and protected, maximizing the number of samples collected and avoiding all samples from falling during the process of the entire device entering and exiting, thus preventing ineffective operations.

[0033] Furthermore, the feedback control component at least includes a main control center 10, a drive shaft 6, a drive disk 11, a connecting rod 12, a connecting sleeve 13, and a brake block 14 arranged from top to bottom. Among them, the main control center 10 is connected to the drive shaft 6 for data transmission, the drive shaft 6 is fixedly connected to the drive disk 11, the drive disk 11 is fixedly connected to the connecting rod 12, the connecting rod 12 is fixedly connected to the connecting sleeve 13, and the connecting sleeve 13 is fixedly connected to the brake block 14. In this embodiment, the main control center 10, the drive shaft 6, the drive disk 11, the connecting rod 12, the connecting sleeve 13, and the brake block 14 are connected in sequence. By controlling the rotation of the drive shaft 6 by the main control center 10, the drive disk 11, the connecting rod 12, the connecting sleeve 13 sliding in the chute 5, and the brake block 14 sliding in the chute 5 are driven in sequence. After the brake block 14 moves to the specified position, it contacts the main shaft 4 and causes the main shaft 4 to stop rotating.

[0034] Further, the connecting platform 3 is externally connected with a first camera 15, a second camera 16, and a third camera 17. The first camera 15 is arranged at an interval from the second camera 16, the second camera 16 is arranged at an interval from the third camera 17, and the third camera 17 is arranged at an interval from the first camera 15. The connecting platform 3 is electrically connected with a first light source 19, a second light source 20, and a third light source 21. The first light source 19 is arranged beside the first camera 15, the second light source 20 is arranged beside the second camera 16, and the third light source 21 is arranged beside the third camera 17. It should be noted that, through the arranged first camera 15, second camera 16, and third camera 17, the internal conditions of the digestive tract are acquired. Through the arranged first light source 19, second light source 20, and third light source 21, sufficient light is provided for the first camera 15, second camera 16, and third camera 17 respectively, ensuring the normal operation of the first camera 15, second camera 16, and third camera 17, and making the entire sampler more visual.

[0035] Further, an outer sleeve 22 is sleeved on the outer periphery of the connecting column 8, and at least one circle of mesh holes 23 for blocking foreign objects and ensuring air circulation is arranged at intervals on the peripheral surface of the outer sleeve 22.

[0036] It should be noted that by arranging the outer sleeve 22 and extending the upper end of the spiral scraping blade 7 into it, the isolation of the remaining substances in the digestive tract during the extraction process is realized. At the same time, the collected sample can enter the outer sleeve 22 along the spiral structure and be effectively protected, avoiding a large amount of dropping during the process of the device entering and exiting. Through the mesh holes 23 on the outer sleeve 22, a certain amount of sample can be effectively discharged when the sample volume is too large, and it can also play an auxiliary role in ventilation.

[0037] Further, a first control unit and a second control unit connected by data are configured in the main control center 10. Among them, the first control unit is electrically connected to the main shaft 4 and controls the rotation of the main shaft 4. The second control unit controls the locking of the main shaft 4 by the brake block 14 based on the pressing information of the pressure sensor 9.

[0038] It should be noted that the main control center 10 is configured with a first control unit and a second control unit. The first control unit is used to control the rotation of the main shaft 4. The second control unit receives the pressure contact information transmitted by the pressure contact sensor 9, and after receiving the pressure contact information, controls the brake block 14 to start working, thereby causing the main shaft 4 to stop rotating. Specifically, the first control unit of the main control center 10 controls the rotation of the main shaft 4, drives the connecting column 8 to rotate, and the connecting column 8 drives the scraping blade 7 to perform sample collection. When a sample is collected, that is, when the pressure contact sensor 9 senses the attachment of the sample, the pressure contact sensor 9 will transmit the pressure contact information to the second control unit of the main control center 10 to chain-drive the brake block 14, and then drive the pressing and locking mechanism to lock the main shaft 4, that is, prevent it from rotating. At this time, the scraping blade 7 stops sample acquisition, and the operator withdraws the sampler body to complete the sampling. Through the linkage cooperation among the sampling component, the feedback control component, the main control center 10, and the pressure contact sensor 9 in this embodiment, precise control of the sample collection volume and precise regulation of the collection operation process are achieved.

[0039] Furthermore, a pressing and locking mechanism is connected between the main shaft 4 and the brake block 14. By setting the pressing and locking mechanism, when the brake block 14 starts to work, the brake block 14 drives the pressing and locking mechanism to lock the main shaft 4, and finally the main shaft 4 stops rotating.

[0040] To better understand the present application, a method for collecting digestive tract tumor cells is provided, including:

[0041] Step 1. Connect the external connecting pipe 2 to form the sampler body;

[0042] Step 2. Manually insert the sampler body into the affected area of the digestive tract;

[0043] Step 3. Control the feedback control component and the sampling component to operate;

[0044] Step 4. After obtaining the tumor cells, stop sampling.

[0045] So far, the embodiments of the present disclosure have been described in detail. To avoid obscuring the concept of the present disclosure, some details well known in the art have not been described. Those skilled in the art can fully understand how to implement the technical solutions disclosed herein based on the above description.

[0046] Although some specific embodiments of the present disclosure have been described in detail by way of examples, those skilled in the art should understand that the above examples are only for illustration and not for limiting the scope of the present disclosure. Those skilled in the art should understand that the above embodiments can be modified or some technical features can be equivalently replaced without departing from the scope and spirit of the present disclosure. The scope of the present disclosure is defined by the appended claims.

Claims

1. A digestive tract tumor cell collector, characterized in that: include: The device body at least comprises a connecting member (1) and an external tube (2) connected in sequence, the external tube (2) being detachably connected to the connecting member (1), the connecting member (1) comprising a connecting platform (3) and a main shaft (4), the main shaft (4) passing through the connecting platform (3) and being connected to a sampling component; a slide groove (5) is provided on the connecting platform (3), a feedback control component is slidably connected in the slide groove (5), the feedback control component is electrically connected to the sampling component and is connected to the main shaft (4) via a wire (18), and the feedback control component feedback-adjusts the main shaft (4).

2. The collector according to claim 1, characterized in that: The sampling component at least comprises a scraper (7), a connecting column (8) and a pressure touch sensor (9); one end of the connecting column (8) is detachably connected to the scraper (7), and the other end is connected to the main shaft (4); the scraper (7) is provided with a pressure touch sensor (9), and the pressure touch sensor (9) is data-connected to the feedback control component. When cells are collected and contact the surface of the pressure touch sensor (9), the pressure touch sensor (9) transmits pressure touch information to the feedback control component.

3. The collector according to claim 2, characterized in that: The feedback control component at least comprises a main control center (10), a drive shaft (6), a drive disk (11), a connecting rod (12), a connecting sleeve (13) and a brake block (14) arranged from top to bottom, wherein the main control center (10) is data connected to the drive shaft (6), the drive shaft (6) is fixedly connected to the drive disk (11), the drive disk (11) is fixedly connected to the connecting rod (12), the connecting rod (12) is fixedly connected to the connecting sleeve (13), and the connecting sleeve (13) is fixedly connected to the brake block (14).

4. The collector according to claim 1, characterized in that: The connection platform (3) is externally connected to a first camera (15), a second camera (16) and a third camera (17); the first camera (15) is arranged to be spaced apart from the second camera (16); the second camera (16) is arranged to be spaced apart from the third camera (17); and the third camera (17) is arranged to be spaced apart from the first camera (15).

5. The collector according to claim 4, characterized in that: The connection platform (3) is electrically connected to a first light source (19), a second light source (20) and a third light source (21); the first light source (19) is arranged next to the first camera (15), the second light source (20) is arranged next to the second camera (16), and the third light source (21) is arranged next to the third camera (17).

6. The collector according to claim 2, characterized in that: The outer periphery of the connecting column (8) is provided with an outer sleeve (22), and the outer periphery of the outer sleeve (22) is provided with at least one circle of mesh holes (23) for shielding foreign matter and ensuring air circulation.

7. The collector according to claim 3, characterized in that: The main control center (10) is provided with a first control unit and a data-connected second control unit, wherein the first control unit is electrically connected to the main shaft (4) and controls the rotation of the main shaft (4), and the second control unit controls the brake block (14) to lock the main shaft (4) based on the pressure touch information of the pressure touch sensor (9).

8. The collector according to claim 7, characterized in that: A clamping and locking mechanism is connected between the main shaft (4) and the brake block (14).

9. A method for collecting digestive tract tumor cells, characterized in that: include: Step 1. Connect the external pipe (2) to form the collector body; Step 2. Manually insert the collector body into the affected part of the digestive tract; Step 3. Control the feedback control component and the sampling component operation; Step 4. After obtaining tumor cells, stop sampling.

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