Bacteriostatic soothing composition as well as preparation method and application thereof

Abstract

The invention discloses a bacteriostatic soothing composition, a preparation method and application, and belongs to the field of daily chemicals. The bacteriostatic soothing composition is composed of a polyamino acid compound, a cyclodextrin compound and an oil-soluble compound, wherein the mass ratio of the polyamino acid compound to the cyclodextrin compound to the oil-soluble compound is (0.1-1.0): (1-5): 1. The composition disclosed by the invention is natural in source, good in water solubility and biological safety and low in cost, has excellent antibacterial performance, can effectively reduce stimulation of substances such as a bacteriostatic agent to human skin, has good compatibility in daily chemical products, and is wide in application field.

Description

Technical Field

[0001] The present invention relates to the field of daily chemical products, and particularly to an antibacterial and soothing composition, a preparation method and an application thereof. Background Art

[0002] There are various resident bacteria and opportunistic pathogens on the surface of human skin, such as Malassezia, Propionibacterium acnes, etc. Many skin diseases, such as pityriasis versicolor, Malassezia folliculitis, seborrheic dermatitis, atopic dermatitis, psoriasis, acne, etc., are closely related to them. The incidence of these common skin diseases is extremely high, and the high-incidence areas are mostly distributed in the tropics and subtropics. Moreover, many diseases often recur, accompanied by obvious itching symptoms, which are unbearable and seriously affect the physical and mental health of patients.

[0003] At present, for the problems of dandruff and dermatitis caused by Malassezia, the mainstream antidandruff agents used in the market include piroctone olamine (OCT), zinc pyrithione (ZPT), selenium disulfide, etc. Among them, OCT has good antidandruff effect but high production cost, is prone to discoloration when encountering metal ions and light, and its irritation can cause scalp itching in some users; ZPT cannot be applied to transparent shampoos and products containing chelating agents such as EDTA, and is prohibited in the European Union; selenium disulfide has strong irritation, color and smell, and is insoluble in water. For skin acne or dermatitis, salicylic acid is currently used more, but it has high irritation, limited applicable population, and may cause epidermal dryness after use.

[0004] Patent CN112675056A provides a shampoo with antidandruff and soothing effects, but it simply dissolves piroctone olamine in a surfactant and then physically mixes it with plant extracts. The steps in the production and preparation of the product are troublesome, and various aqueous and oily raw materials need to be mixed in a specific order, and it cannot provide a raw material with wide applicability and good compatibility. Currently, in the market, salicylic acid esters derivatives are mostly used to replace salicylic acid with strong irritation. The production of salicylic acid esters derivatives mainly uses chemical methods, and the commonly used ones include solid acid catalysis method, other catalyst catalysis method, transesterification method, phase transfer catalysis method and microwave synthesis method, etc., but the modification further increases the use cost of this kind of raw material.

[0005] In addition, the compound use of various raw materials is also restricted by the limited standards in the "List of Cosmetic Ingredients Used (2021 Edition)".

[0006] Therefore, based on the problems existing in the current daily chemical market, it is urgent to develop a raw material that has antibacterial, soothing effects and low irritation, and this raw material needs to have good compatibility and low cost in daily chemical products to meet the market demand. Summary of the Invention

[0007] In view of the above problems, the object of the present invention is to provide an antibacterial and soothing composition, a preparation method and an application. The composition is natural in source, has good water solubility, biological safety, low cost, and while having excellent antibacterial performance, can effectively reduce the irritation to human skin caused by substances such as antibacterial agents, has good compatibility in daily chemical products, and has a wide range of application fields.

[0008] To achieve the above object, the technical solution of the present invention is as follows:

[0009] An antibacterial and soothing composition, which is composed of a polyamino acid compound, a cyclodextrin compound and an oil-soluble compound, wherein the mass ratio of the polyamino acid compound, the cyclodextrin compound and the oil-soluble compound is (0.1 - 1.0):(1 - 5):1.

[0010] Further, the polyamino acid compound is one or a combination of two or more of polylysine, polyarginine, polyhistidine and hydrochloride, citrate derivatives of the above polyamino acids

[0011] Further, the cyclodextrin compound is one or a combination of two or more of cyclodextrin, hydroxypropyl cyclodextrin, methyl cyclodextrin, carboxymethyl cyclodextrin, sulfonic acid group cyclodextrin, phosphoric acid group cyclodextrin.

[0012] Further, the oil-soluble compound is one or a combination of two or more of bisabolol, trans-4-tert-butylcyclohexanol, hydroxyphenyl propionamide benzoic acid, Poria cocos sclerotium extract, Piper wattii root extract, Sophora flavescens extract, Portulaca oleracea extract.

[0013] Further, the preparation method includes the following steps:

[0014] (1) Dissolve the polyamino acid compound and the cyclodextrin compound in deionized water to form a stable complex aqueous solution;

[0015] (2) Dissolve the oil-soluble compound in a cosolvent to form a uniform solution;

[0016] (3) Add the solution in step (2) to the complex aqueous solution in step (1), adjust the pH, and stir or ultrasonically react;

[0017] (4) After the reaction is completed, the product is obtained by cooling and precipitation or centrifugal separation, and the antibacterial and soothing composition is obtained by vacuum drying or freeze drying.

[0018] Further, in step (1), the mass ratio of the total mass of the polyamino acid compound and the cyclodextrin compound to the mass of deionized water is (0.05 - 0.3):1.

[0019] Further, in step (2), the mass ratio of the oil-soluble compound to the cosolvent is (0.5-1):1.

[0020] Further, in step (2), the cosolvent is one or more combinations of ethanol, isopropanol, propylene glycol, butylene glycol, 1,2-pentanediol, hexanediol, polyethylene glycol, and polypropylene glycol.

[0021] Further, in step (3), the reaction temperature is 25-55°C, the reaction time is 0.5-6 h, the pH is 4-7, the stirring speed is 100-600 rpm, and the ultrasonic power is 200-400 W.

[0022] The application of an antibacterial and soothing composition is mainly applied to daily chemical products, including washing and care products and skin care products, especially applied to body lotions, serums, creams, shampoos, body washes, and toners, etc.

[0023] The beneficial effects of the present invention:

[0024] (1) The polyamino acid compound of the present invention has excellent antibacterial properties, and has excellent antibacterial effects on bacteria and fungi (such as Malassezia and Propionibacterium acnes), and has good biocompatibility. The polyamino acid itself and its degradation products are safe and non-toxic, and are safe for the human body and the environment.

[0025] (2) The cyclodextrin compound of the present invention provides a cavity structure, which can effectively encapsulate the oil-soluble compound; at the same time, it is compounded with the polyamino acid compound, providing a stable bridging effect.

[0026] (3) The oil-soluble compound of the present invention has a soothing effect, and can effectively reduce the irritation caused by substances such as antibacterial agents to the human skin in the presence of antibacterial agents.

[0027] (4) The polyamino acid compound contains groups such as amino groups that can form hydrogen bonds, and is positively charged under acidic conditions; there are a large number of hydroxyl groups on the outer surface of the cyclodextrin compound. The hydrogen atoms in these hydroxyl groups can act as hydrogen bond donors, and the oxygen atoms can act as hydrogen bond acceptors. Under certain conditions, these hydroxyl groups may dissociate, making the cyclodextrin compound as a whole carry a certain negative charge; the two can form a stable complex through hydrogen bond interaction and electrostatic interaction in an aqueous solution.

[0028] (5) The complex formed by the polyamino acid compound and the cyclodextrin compound has excellent water solubility and a hydrophobic cavity structure, which can effectively encapsulate the oil-soluble compound that is difficult to dissolve in water, greatly increasing its solubility in water, solving the problem that it cannot be dissolved in the aqueous phase, and can slowly release the oil-soluble compound in the application system to protect its efficacy and activity.

[0029] (6) The antibacterial and soothing composition of the present invention complies with the limited standards in the "List of Cosmetic Ingredients in Use (2021 Edition)" and is applicable to various types of daily chemical products with excellent compatibility.

[0030] (7) The preparation process of the antibacterial and soothing composition of the present invention is simple, suitable for industrial production, and widely used in the daily chemical field. Description of the Drawings

[0031] Figure 1 Digital photos of the products of Example 4 and Comparative Example 1 redissolved in deionized water.

[0032] Figure 2 Digital photos of the antibacterial effects of Examples 4-7 and Comparative Example 3.

[0033] Figure 3 Chorioallantoic membrane test diagrams of Example 8 and Comparative Examples 4-7.

[0034] Figure 4 Chorioallantoic membrane test diagrams of Example 9 and Comparative Examples 8-10. Specific Implementation Methods

[0035] The technical solutions of the present invention will be further described below in conjunction with the examples. However, it should not be limited thereto. Those that are equivalent substitutions for the technical solutions of the present invention should also be within the scope of protection; in addition, adding other active ingredients to the protection scheme of the present invention is a well-known technical means in the art and should also be within the scope of protection. Unless otherwise specified, the devices and equipment used in the following examples are all conventional devices and equipment in the art. Unless otherwise specified, the raw materials used in the following examples can be obtained commercially. Unless otherwise specified, the technical means used in the following examples are all well-known technical means in the art.

[0036] Example 1 (low complex ratio)

[0037] Dissolve 0.1 g of polylysine and 1 g of hydroxypropyl cyclodextrin in 20 g of deionized water and stir to dissolve to form Complex water Solution 1 ; Dissolve 1 g of bisabolol in 2 g of propylene glycol, and then add it to In the complex aqueous solution 1, adjust the pH to 7, and the reaction temperature is At 25°C, react with 400 W ultrasound for 0.5 h. After the reaction, cool the solution to room temperature, and then slowly add it at low temperature (0-5°C) Add acetone or the like to precipitate the product, and vacuum dry to obtain the antibacterial and soothing composition 1.

[0038] Example 2 (ring, soothing ratio)

[0039] Dissolve 0.1 g of polylysine and 5 g of hydroxypropyl cyclodextrin in 20 g of deionized water, and stir to dissolve to form complex water Solution 2;Dissolve 1 g of bisabolol in 2 g of propylene glycol, then add it to Complex Aqueous Solution 2, adjust the pH to 7, the reaction temperature is 25 °C, and react under 400 W ultrasonic for 0.5 h. After the reaction, cool the solution to room temperature, and then slowly add Add acetone or the like to precipitate the product, and vacuum dry to obtain the antibacterial and soothing composition 2.

[0040] Example 3 (higher complex ratio)

[0041] Dissolve 1 g of polylysine and 5 g of hydroxypropyl cyclodextrin in 20 g of deionized water, and stir to dissolve to form complex aqueous Solution 3; Dissolve 1 g of bisabolol in 2 g of propylene glycol, and then add it to Complex aqueous solution 3 , adjust the pH to 7, the reaction temperature is 25 °C, react under 400 W ultrasonic for 0.5 h. After the reaction, cool the solution to room temperature, and then slowly add acetone, etc. at low temperature (0 - 5 °C) to precipitate the product, and dry it under vacuum to obtain Antibacterial and soothing composition 3 .

[0042] Example 4 (Changing the type of complex, optimizing the ratio)

[0043] Dissolve 0.5 g of polylysine hydrochloride and 3 g of hydroxypropyl cyclodextrin in 20 g of deionized water, and stir to dissolve to form Complex Complex aqueous solution 4 ; Dissolve 1 g of hydroxyphenylpropionyl benzoic acid in 1 g of butanediol, and then add it to Complex aqueous solution 4 , adjust the pH to 4, the reaction temperature is 40 °C, stir and react at 600 rpm for 6 h. After the reaction, cool the solution to room temperature, and then slowly add ether, etc. at low temperature (0 - 5 °C) to precipitate the product, and dry it under vacuum to obtain Antibacterial and soothing composition 4 .

[0044] Example 5 (Changing the type of complex, optimizing the ratio)

[0045] Dissolve 0.5 g of polylysine hydrochloride and 3 g of sulfonic acid group cyclodextrin in 20 g of deionized water, and stir to dissolve to form Complex Complex aqueous solution 5 ; Dissolve 1 g of hydroxyphenylpropionyl benzoic acid in 1 g of butanediol, and then add it to Complex aqueous solution 5 , adjust the pH to 4, the reaction temperature is 40 °C, stir and react at 600 rpm for 6 h. After the reaction, cool the solution to room temperature, and then slowly add ether, etc. at low temperature (0 - 5 °C) to precipitate the product, and dry it under vacuum to obtain Antibacterial and soothing composition 5 .

[0046] Example 6 (Changing the type of complex, optimizing the ratio)

[0047] Dissolve 0.5 g of polylysine citrate, 0.5 g of polyhistidine, 1 g of sulfonic acid group cyclodextrin and 2 g of hydroxypropyl cyclodextrin in 20 g of deionized water, and stir to dissolve to form Complex aqueous solution 6; Dissolve 0.5 g of hydroxyphenylpropionamide benzoic acid and 0.5 g of Wolfiporia cocos sclerotium extract in 1 g of butanediol, and then add it to Complex aqueous solution 6 ; adjust the pH to 5.5, the reaction temperature to 50 °C, stir and react at 400 rpm for 3 h. After the reaction, cool the solution to room temperature, and then slowly add ether, etc. at low temperature (0 - 5 °C) to precipitate the product, and vacuum dry to obtain Antibacterial and soothing composition 6 .

[0048] Example 7 (Changing the type of complex and optimizing the ratio)

[0049] Dissolve 0.9 g of polylysine citrate, 0.1 g of polyhistidine, 0.3 g of cyclodextrin, and 2.7 g of carboxymethyl cyclodextrin in 20 g of deionized water, and stir to dissolve to form Complex aqueous solution 7 ; Dissolve 0.5 g of hydroxyphenylpropionamide benzoic acid and 0.5 g of Wolfiporia cocos sclerotium extract in 1 g of butanediol, and then add it to Complex aqueous solution 7 ; adjust the pH to 5.5, the reaction temperature to 50 °C, stir and react at 400 rpm for 3 h. After the reaction, cool the solution to room temperature, and then slowly add ether, etc. at low temperature (0 - 5 °C) to precipitate the product, and vacuum dry to obtain Antibacterial and soothing composition 7 .

[0050] Comparative Example 1 (Example 4, less cyclodextrin)

[0051] Dissolve 0.5 g of polylysine hydrochloride in 20 g of deionized water, and stir to dissolve to form an aqueous solution; dissolve 1 g of hydroxyphenylpropionamide benzoic acid in 1 g of butanediol, and then add it to the above aqueous solution, adjust the pH to 4, the reaction temperature to 40 °C, stir and react at 600 rpm for 6 h. After the reaction, cool the solution to room temperature, and centrifuge to obtain Product 1 .

[0052] Comparative Example 2 (Example 4, less soothing substance)

[0053] Dissolve 0.5 g of polylysine hydrochloride and 3 g of hydroxypropyl cyclodextrin in 20 g of deionized water, stir to dissolve, adjust the pH to 4, the reaction temperature to 40 °C, stir and react at 600 rpm for 6 h. After the reaction, cool the solution to room temperature, and then at low temperature (0 - 5 °C)

[0054] slowly add ether, etc. to precipitate the product, and vacuum dry to obtain Product 2 .

[0055] Comparative Example 3 (Example 4, less bacteriostatic agent)

[0056] Dissolve 3 g of hydroxypropyl cyclodextrin in 20 g of deionized water; dissolve 1 g of hydroxyphenylpropionyl benzamide in 1 g of butanediol, and then add it to the above solution. Adjust the pH to 4, the reaction temperature to 40 °C, and stir the reaction at 600 rpm for 6 h. After the reaction, cool the solution to room temperature, and then slowly add ether, etc. at a low temperature (0 - 5 °C) to precipitate the product, and dry it under vacuum to obtain Product 3 .

[0057] Redissolve the products obtained in Examples 1 - 7 and Comparative Examples 1 - 3 in deionized water. In Comparative Example 1, a homogeneous solution could not be obtained, and an oil-water stratification phenomenon ( Figure 1 ) occurred, making it impossible to carry out subsequent tests.

[0058] According to the anti-(bacteriostatic) experiment in the "Disinfection Technical Specification (2002 Edition)", test the bacteriostatic effect of the above solution (select Staphylococcus aureus as the strain), and the measured diameters of the bacteriostatic zones are listed in Table 1.

[0059] Judgment of bacteriostatic effect:

[0060] If the diameter of the bacteriostatic zone is greater than 7 mm, it is judged to have a bacteriostatic effect; if the diameter of the bacteriostatic zone is less than or equal to 7 mm, it is judged to have no bacteriostatic effect.

[0061] According to the relevant requirements of the "Chorioallantoic Membrane Test of Chicken Embryos for Eye Irritation / Corrosion of Cosmetics (SN / T 2329 - 2009)", conduct irritation scoring, and the results are listed in Table 1.

[0062] Irritation scoring method:

[0063]

[0064] Table 1 Diameters of the bacteriostatic zones of the samples

[0065]

[0066]

[0067] As can be seen from the above data, in Examples 2 and 3, as the content of the polyamino acid compound increases, its antibacterial effect increases significantly; compared with Example 1 and Example 2, as the content of the cyclodextrin compound increases, while the polyamino acid compound is complexed, more cavity structures are provided, which can effectively encapsulate more oil-soluble compounds, and its irritation is greatly reduced. It can be seen from Examples 4-7 that when the polyamino acid compound, the cyclodextrin compound and the oil-soluble compound are combined in appropriate proportions, the product can simultaneously have excellent antibacterial properties and low irritation; compared with Example 4 and Comparative Examples 1-3, it can be seen that when there is no cyclodextrin compound as an intermediate, the system cannot be stable; when there is no polyamino acid compound, although the cyclodextrin compound and the oil-soluble compound can be encapsulated, it does not have antibacterial properties, and when the oil-soluble compound is lacking, although a stable complex can be formed, its irritation is relatively large; therefore, in this application, the polyamino acid compound and the cyclodextrin compound form a complex, and the hydrophobic cavity structure can effectively encapsulate the oil-soluble compound that is insoluble in water, greatly increasing its solubility in water, solving the problem of its insolubility in the aqueous phase, and can release the oil-soluble compound in the application system, reducing the irritation of the raw material and protecting its efficacy and activity.

[0068] Example 8

[0069] Apply the antibacterial and soothing composition 4 of Example 4 to shampoo, and the specific formula is shown in Table 2.

[0070] Comparative Example 4

[0071] Apply the product 2 of Comparative Example 2 to shampoo, and the specific formula is shown in Table 2.

[0072] Comparative Example 5

[0073] Apply the product 3 of Comparative Example 3 to shampoo, and the specific formula is shown in Table 2.

[0074] Comparative Example 6

[0075] Apply piroctone olamine (OCT) to shampoo, and the specific formula is shown in Table 2.

[0076] Comparative Example 7

[0077] Apply zinc pyrithione (ZPT) to shampoo, and the specific formula is shown in Table 2.

[0078] Table 2 Shampoo formula (%)

[0079] Raw materials Example 8 Comparative example 4 Comparative example 5 Comparative example 6 Comparative example 7 Sodium lauryl polyoxyethylene ether sulfate 20 20 20 20 20 Cocamidopropyl betaine 8 8 8 8 8 Sodium chloride 0.6 0.6 0.6 0.6 0.6 Phenoxyethanol 0.5 0.5 0.5 0.5 0.5 Coconut oil fatty acid monoethanolamide 0.5 0.5 0.5 0.5 0.5 Sodium benzoate 0.4 0.4 0.4 0.4 0.4 Polyquaternium-10 0.3 0.3 0.3 0.3 0.3 Antibacterial and soothing composition 4 0.2 / / / / Product 2 / 0.2 / / / Product 3 / / 0.2 / / Piroctone olamine / / / 0.2 / Zinc pyrithione / / / / 0.2 Citric acid 0.3 0.3 0.3 0.3 0.3 Disodium ethylenediaminetetraacetate 0.1 0.1 0.1 0.1 0.1 Deionized water 69.1 69.1 69.1 69.1 69.1

[0080] According to the suspension quantitative method in "QB / T 2738-2012 Evaluation Method for Antibacterial and Bacteriostatic Effects of Daily Chemical Products", the bacteriostatic effects of Example 8 and Comparative Examples 4-7 were evaluated, and their bacteriostatic effects on Malassezia were tested. The results are listed in Table 3.

[0081] According to the relevant requirements of "SN / T 2329-2009 Chicken Embryo Chorioallantoic Membrane Test for Eye Irritation / Corrosion of Cosmetics", the irritation of Example 8 and Comparative Examples 4-7 was evaluated. The results are listed in Table 3.

[0082] Table 3

[0083] Sample Bacteriostatic rate Stimulation score Stimulation classification Example 8 >99％ 3.18 Mild irritation Comparative example 4 94 8.96 Moderate irritation Comparative example 5 2 6.22 Moderate irritation Comparative example 6 68 11.28 Strong irritation Comparative example 7 30 10.94 Strong irritation

[0084] From the data in the above table, it can be seen that compared with the market-common anti-dandruff agents, under the condition of the same addition amount, the shampoo added with the antibacterial and soothing composition of the present application has a more excellent antibacterial effect on Malassezia (fungus), and at the same time has less irritation and is more suitable for sensitive people; compared with Example 8 and Comparative Example 4, it can be seen that in addition to the reduced irritation, when only polyamino acid compounds and cyclodextrin compounds exist, the antibacterial effect of Example 8 is still better than that of Comparative Example 4. This is because the soothing oil-soluble compounds encapsulated in the cavity can synergistically enhance the effect with polyamino acid compounds to a certain extent, and the slow release after encapsulation can prolong the antibacterial effect.

[0085] Example 9

[0086] The antibacterial and soothing composition 4 of Example 4 was applied to essence water, and the specific formula is shown in Table 4.

[0087] Comparative Example 8

[0088] The product 2 of Comparative Example 2 was applied to essence water, and the specific formula is shown in Table 4.

[0089] Comparative Example 9

[0090] The product 3 of Comparative Example 3 was applied to essence water, and the specific formula is shown in Table 4.

[0091] Comparative Example 10

[0092] Salicylic acid was applied to essence water, and the specific formula is shown in Table 4.

[0093] Table 4 Essence Water Formula (%)

[0094] Raw materials Example 9 Comparative example 8 Comparative example 9 Comparative example 10 Deionized water 88.9 88.9 88.9 88.9 Butylene glycol 5 5 5 5 Glycerol 3 3 3 3 Propylene glycol 2 2 2 2 Panthenol 0.5 0.5 0.5 0.5 Antibacterial and soothing composition 4 0.1 / / / Product 2 / 0.1 / / Product 3 / / 0.1 / Salicylic acid / / / 0.1 Sodium hyaluronate 0.1 0.1 0.1 0.1 p-Hydroxyacetophenone 0.2 0.2 0.2 0.2 1,2-Hexanediol 0.2 0.2 0.2 0.2

[0095] According to the anti-(bacteriostatic) experiment in "Disinfection Technical Specification (2002 Edition)", the bacteriostatic effects of Example 9 and Comparative Examples 8-10 were evaluated, and their bacteriostatic effects on Propionibacterium acnes were tested. The measured diameters of the inhibition zones are listed in Table 5.

[0096] According to the relevant requirements of "SN / T 2329-2009 Chicken Embryo Chorioallantoic Membrane Test for Eye Irritation / Corrosion of Cosmetics", the irritation evaluation was carried out on Example 9 and Comparative Examples 8-10, and the results are listed in Table 5.

[0097] Table 5

[0098] Sample Diameter of bacteriostatic ring / mm Whether it is bacteriostatic Stimulation score Stimulation classification Example 9 14.7±0.67 Yes 3.53 Mild irritation Comparative example 8 11.30±0.84 Yes 8.75 Moderate irritation Comparative example 9 5.10±0.22 No 5.82 Moderate irritation Comparative example 10 5.30±0.27 No 9.33 Strong irritation

[0099] It can be seen from the data in the above table that under the condition of the same addition amount, the essence water added with the antibacterial and soothing composition of the present application has a more excellent antibacterial effect on Propionibacterium acnes (bacteria), and at the same time has less irritation and is more suitable for people with sensitive skin.

[0100] Those of ordinary skill in the art should understand that the above are only specific embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An antibacterial soothing composition, characterized in that: The antibacterial soothing composition is composed of a polyamino acid compound, a cyclodextrin compound and an oil-soluble compound, wherein the mass ratio of the polyamino acid compound, the cyclodextrin compound and the oil-soluble compound is (0.1-1.0):(1-5):

1.

2. The antibacterial soothing composition according to claim 1, characterized in that: The polyamino acid compound is one or a combination of two or more of polylysine, polyarginine, polyhistidine and their hydrochloride and citrate derivatives.

3. The antibacterial soothing composition according to claim 1, characterized in that: The cyclodextrin compound is one or a combination of two or more of cyclodextrin, hydroxypropyl cyclodextrin, methyl cyclodextrin, carboxymethyl cyclodextrin, sulfonic acid cyclodextrin and phosphate cyclodextrin.

4. The antibacterial soothing composition according to claim 1, characterized in that: The oil-soluble compound is one or a combination of two or more of bisabolol, trans-4-tert-butyl cyclohexanol, hydroxyphenylpropionamide benzoic acid, Poria cocos sclerotium extract, Piper methysticum root extract, Sophora flavescens extract, and Portulaca oleracea extract.

5. A method for preparing an antibacterial soothing composition, characterized in that: The preparation method comprises the following steps: (1) dissolving a polyamino acid compound and a cyclodextrin compound in deionized water to form a stable complex aqueous solution; (2) dissolving the oil-soluble compound in a co-solvent to form a uniform solution; (3) adding the solution of step (2) to the aqueous solution of the complex of step (1), adjusting the pH, and stirring or ultrasonically reacting; (4) After the reaction is completed, the product is obtained by cooling and dissolving or centrifugation, and the antibacterial soothing composition is obtained by vacuum drying or freeze drying.

6. The method for preparing an antibacterial soothing composition according to claim 5, characterized in that: In step (1), the mass ratio of the total mass of the polyamino acid compound and the cyclodextrin compound to the mass of deionized water is (0.05-0.3):

1.

7. The method for preparing an antibacterial soothing composition according to claim 5, characterized in that: In step (2), the mass ratio of the oil-soluble compound to the co-solvent is (0.5-1):

1.

8. The method for preparing an antibacterial soothing composition according to claim 5, characterized in that: In step (2), the cosolvent is one or a combination of two or more of ethanol, isopropanol, propylene glycol, butylene glycol, 1,2-pentanediol, hexylene glycol, polyethylene glycol, and polypropylene glycol.

9. The method for preparing an antibacterial soothing composition according to claim 5, characterized in that: In step (3), the reaction temperature is 25-55°C, the reaction time is 0.5-6h, the pH is 4-7, the stirring speed is 100-600rpm, and the ultrasonic power is 200-400W.

10. Use of the antibacterial soothing composition according to any one of claims 1 to 4 or the antibacterial soothing composition prepared by the preparation method according to any one of claims 5 to 9, characterized in that: The antibacterial soothing composition is used in daily chemical products, including washing and skin care products.

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