Inactivation cabinet

Abstract

The invention discloses an inactivation cabinet, which comprises a cabinet body, and a plurality of suspension supports arranged side by side and used for suspending a plurality of independent initial blood bags respectively are arranged in the cabinet body from top to bottom in sequence; the plurality of flow controllers are arranged side by side and are respectively used for adjusting the flow speeds of the plurality of blood treatment pipelines; the plurality of ultraviolet lamp boxes are arranged side by side and are respectively used for irradiating the plurality of blood treatment illumination plates; the shaking table is used for uniformly shaking the blood collection bag, and the initial blood bag is sequentially connected with a blood treatment illumination plate and the blood collection bag through the blood treatment pipeline. According to the invention, accurate temperature and ultraviolet irradiation dose control is carried out on to-be-treated blood through a software control system, so that a safe and efficient pathogen inactivation effect is achieved.

Description

Technical Field

[0001] The present application relates to the inactivation of blood component pathogens, and in particular to an inactivation cabinet. Background Art

[0002] If the blood components are not inactivated for pathogens during clinical blood transfusion, the donor blood carrying pathogens (including viruses, bacteria, parasites, and microorganisms such as white blood cells) can be transfused into the recipient's body, which can transmit the pathogens to the recipient population through blood transfusion, causing public health and safety problems, and may also lead to ineffective blood transfusion and even clinical events such as sepsis or graft-versus-host disease (TA-GVHD). The blood components treated with ultraviolet light do not have any residual chemicals, and the precisely controlled ultraviolet light dose does not damage the blood function. The development of this technology provides a firewall and guarantee for the safety and effectiveness of blood transfusion.

[0003] In the existing blood light treatment technology, the plastic blood bag containing the treated blood is generally directly irradiated. This method has strict requirements on the liquid thickness of the treated blood and the light transmittance of the plastic blood bag, the inactivation efficiency is low, and long-term illumination will cause damage to the effective components of the blood. The present invention provides an effective inactivation device that can improve the inactivation efficiency. Summary of the invention

[0004] The purpose of the present invention is to provide an inactivation cabinet, which can inactivate pathogens that may exist in the blood, effectively avoid the occurrence of transfusion-related infectious diseases and clinical events such as bacteremia and transfusion-associated graft-versus-host disease (TA-GVHD). At the same time, the product can accurately control the light dose of ultraviolet rays without damaging blood function, providing a firewall and guarantee for the safety and effectiveness of blood transfusion, and also providing more treatment options for clinical blood transfusion and testing.

[0005] To achieve the above object, the present invention provides the following technical solutions.

[0006] The present application discloses an inactivation cabinet, including a cabinet body, wherein the cabinet body is provided with the following components from top to bottom:

[0007] A plurality of hanging brackets arranged side by side are respectively used to hang a plurality of independent initial blood bags;

[0008] A plurality of flow controllers arranged side by side are respectively used to adjust the flow rates of a plurality of blood processing pipelines;

[0009] A plurality of ultraviolet lamp boxes arranged side by side are respectively used to illuminate a plurality of blood treatment illumination panels;

[0010] Shaker, used to shake the blood collection bag evenly,

[0011] The initial blood bag is connected in sequence to the blood processing illumination plate and the blood collection bag through the blood processing pipeline.

[0012] Preferably, in the above-mentioned inactivation cabinet, the rocking table includes a long plate body and a bed body arranged on both sides of the long plate body, the bed body is arranged in multiple layers, a bag of the blood collection bag is laid flat on each bed body, and the bottom of the long plate body is driven by a first motor to swing horizontally on both sides in turn.

[0013] Preferably, in the above-mentioned inactivation cabinet, the initial blood bags are sequentially hung on different hanging brackets, the flow controllers sequentially control different blood processing pipelines, and the ultraviolet lamp boxes sequentially irradiate different blood processing illumination panels with ultraviolet light.

[0014] Preferably, in the above-mentioned inactivation cabinet, the blood processing illumination board is inserted into a clamping bracket, and the clamping bracket is arranged between two adjacent ultraviolet lamp boxes. The clamping bracket includes two clamping brackets which are symmetrically arranged up and down and are respectively formed with clamping openings.

[0015] Preferably, in the above-mentioned inactivation cabinet, an indicator light is provided on the top of the cabinet, a temperature sensor is provided in the middle of the cabinet, and a temperature control system is provided at the bottom and rear of the cabinet for adjusting the temperature inside the cabinet.

[0016] Preferably, in the above-mentioned inactivation cabinet, an air outlet is arranged above the suspension bracket, and a return air outlet is arranged inside the cabinet between the blood processing illumination panels.

[0017] Preferably, in the above-mentioned inactivation cabinet, a visual door panel is installed on the front of the cabinet body, and the visual door panel is opened and closed by a magnetic door buckle.

[0018] Preferably, in the above-mentioned inactivation cabinet, the flow controller includes a second motor and a transmission shaft driven by the second motor through a gear, a plurality of circular sheets are fixedly sleeved on the transmission shaft in sequence, the circular sheets are engaged with grooves formed on the pump sheet, the pump sheet is arranged to move along the axis direction perpendicular to the axis of the transmission shaft, the axis of the circular sheet is located on one side of the axis of the transmission shaft, and the axis of the circular sheet is parallel to the axis of the transmission shaft, and the axes of the plurality of circular sheets are arranged in a ring shape around the axis of the transmission shaft in sequence,

[0019] The second motor drives the transmission shaft to rotate, and then drives the circular plate body to rotate eccentrically, thereby driving the pump plate to move back and forth.

[0020] Preferably, in the above-mentioned inactivation cabinet, the pump plate is installed on a slot bracket, and the slot bracket forms a pipeline groove on the side of the pump plate away from the transmission shaft, the blood processing pipeline is placed in the pipeline groove, and the pump plate acts on the blood processing pipeline.

[0021] Preferably, in the above-mentioned inactivation cabinet, a switch rod is provided on the outer side of the flow controller.

[0022] Compared with the prior art, the advantages of this technical solution are that the ultraviolet light dose can be accurately controlled without damaging blood function, the use of the inactivation cabinet does not require a special environment, the investment cost is low, and the maintenance is simple. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1 Shown is a three-dimensional diagram of an inactivation cabinet in an embodiment of the present invention;

[0025] Figure 2 Shown is a three-dimensional view of a rocking table in an embodiment of the present invention;

[0026] Figure 3 Shown is a schematic diagram of a clamping bracket in an embodiment of the present invention;

[0027] Figure 4 Shown is a schematic diagram of a flow controller according to an embodiment of the present invention;

[0028] Figure 5 Shown is an internal schematic diagram of a flow controller in an embodiment of the present invention. DETAILED DESCRIPTION

[0029] The following will describe the technical solutions in the embodiments of the present invention in detail in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] Combination Figure 1 As shown, the inactivation cabinet 100 includes a cabinet body 101, and the cabinet body 101 is provided with the following components from top to bottom:

[0031] A plurality of hanging brackets 102 arranged side by side, respectively used to hang a plurality of independent initial blood bags 103;

[0032] A plurality of flow controllers 104 arranged side by side, respectively used to adjust the flow rate of a plurality of blood processing pipelines 105;

[0033] A plurality of UV lamp boxes 106 arranged side by side are used to illuminate a plurality of blood treatment illumination panels 107 respectively;

[0034] A shaking table 108 is used to evenly shake the blood collection bag 109.

[0035] The initial blood bag 103 is connected to the blood processing illumination board 107 and the blood collection bag 109 in sequence through the blood processing pipeline 105 .

[0036] The shaking table 108 includes a long plate 115 and a bed 116 disposed on both sides of the long plate 115. The bed 116 is provided with multiple layers, and a blood collection bag 109 is laid flat on each bed 116. (Note: Figure 1 The blood collection bag is in an upright state for easy viewing, but is laid flat in actual operation). The bottom of the long plate 115 is driven by the first motor 117 to swing horizontally on both sides in sequence. The initial blood bags 103 are sequentially suspended on different suspension brackets 102, the flow controller 104 sequentially controls different blood processing pipelines 105, and the ultraviolet lamp box 106 sequentially irradiates different blood processing illumination panels 107 with ultraviolet light.

[0037] The blood processing illumination board 107 is inserted into the clamping bracket 118 . The clamping bracket 118 is disposed between two adjacent ultraviolet lamp boxes 106 . The clamping bracket 118 includes two clamping brackets 118 symmetrically disposed up and down, and each of the clamping brackets 118 is formed with a clamping opening 119 .

[0038] An indicator light 110 is provided on the top of the cabinet 101. An air outlet 111 is provided above the suspension bracket 102, and an air return port 129 is provided inside the cabinet 101 between the blood treatment illumination panels 107. A temperature sensor 112 is provided in the middle of the cabinet 101. A temperature control system 113 is provided at the bottom and rear of the cabinet 101 to adjust the temperature inside the cabinet 101. A visual door panel (not shown) is installed on the front of the cabinet 101, and the visual door panel is opened and closed by a magnetic door buckle 114.

[0039] In this embodiment, the ultraviolet inactivation cabinet is mainly composed of a cabinet body, a temperature control system, an ultraviolet irradiation system, a flow control system, an oscillation control system, and a software control system. This technical solution is used in conjunction with our patent "202321340942.5 A disposable kit for light inactivation of blood pathogens" to accurately control the ultraviolet irradiation dose of the treated blood to achieve a safe and efficient pathogen inactivation effect.

[0040] This product can inactivate pathogens that may exist in component blood, effectively avoiding the occurrence of transfusion-related infectious diseases and clinical events such as bacteremia and transfusion-associated graft-versus-host disease (TA-GVHD). At the same time, this product can accurately control the light dose of ultraviolet light without damaging blood function, providing a firewall and guarantee for safe and effective blood transfusion, and also providing more treatment options for clinical blood transfusion and testing.

[0041] The ultraviolet inactivation cabinet ensures that the environment of component blood meets the requirements during the processing process through the internal temperature control system and oscillation control system. The ultraviolet irradiation system and flow control system accurately control the energy required for pathogen inactivation, which can not only kill pathogens but also reduce the impact of ultraviolet radiation on blood function.

[0042] Ultraviolet inactivation cabinets do not require radioactive isotopes (such as cobalt-60), avoiding the complex issues of radiation source leakage, storage and waste disposal, and do not require special requirements for operator and environmental safety, complying with the strict regulatory requirements of medical institutions for biosafety.

[0043] The ultraviolet inactivation cabinet can work as soon as it is powered on, and there is no residual risk after it is turned off. It is suitable for immediate on-site treatment (such as blood banks or operating rooms, blood transfusion departments), while gamma irradiation relies on external irradiation centers, which has the risk of transportation delays and contamination.

[0044] The use of UV inactivation cabinets does not require a special environment, has low investment costs, and is simple to maintain. Gamma irradiation facilities require a specific environment and require a radioactive license or dedicated shielding facilities, which are complex to maintain and costly.

[0045] It only takes 3-5 minutes to inactivate a single bag of component blood in an ultraviolet light cabinet, while gamma irradiation requires centralized processing and batch turnover time often exceeds 1 hour.

[0046] Further, the flow controller 104 includes a second motor 120, a transmission shaft 122 driven by the second motor 120 through a gear 121, a plurality of circular sheets 123 are sequentially fixedly sleeved on the transmission shaft 122, the circular sheets 123 are engaged with a groove 125 formed on a pump sheet 124, and the pump sheet 124 is arranged to move along a direction perpendicular to the axis of the transmission shaft 122, the axis of the circular sheet 123 is located on one side of the axis of the transmission shaft 122, and the axis of the circular sheet 123 is parallel to the axis of the transmission shaft 122, and the axes of the plurality of circular sheets 123 are sequentially arranged in a ring shape around the axis of the transmission shaft 122.

[0047] The second motor 120 drives the transmission shaft 122 to rotate, and then drives the circular plate 123 to rotate eccentrically, thereby driving the pump plate 124 to reciprocate.

[0048] The pump plate 124 is mounted on a slot bracket 126. The slot bracket 126 has a pipeline groove 127 formed on the side of the pump plate 124 away from the transmission shaft 122. The pipeline groove 127 is used to place the blood processing pipeline 105. The pump plate 124 acts on the blood processing pipeline 105. A switch rod 128 is arranged outside the flow controller 104.

[0049] In this embodiment, a special flow controller is designed to control the blood flow rate in the blood treatment pipeline. Basically, it is completed by the progressive pushing of the pump plate through the pipeline, and the progressive pushing of multiple pump plates is completed. The reciprocating motion of the pump plate is driven by the circular plate body, and the circular plate body is not concentric with the transmission shaft, that is, when the transmission shaft rotates, the circular plate body will realize a circular motion, thereby realizing the reciprocating motion of the pump plate, and the position of each circular plate body is different, that is, the axis of all circular plates forms a ring around the axis of the transmission shaft, and is arranged in sequence, so that there is a progressive movement of the pump plate, and a progressive reciprocating push is realized to realize blood flow control. This method is different from the traditional peristaltic pump. The way the peristaltic pump squeezes the pipeline will cause physical damage to the blood components.

[0050] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0051] The above is only a specific implementation of the present application. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present application. These improvements and modifications should also be regarded as the scope of protection of the present application.

Claims

1. An inactivation cabinet, characterized in that: It comprises a cabinet, and the cabinet is provided with the following components from top to bottom: A plurality of hanging brackets arranged side by side are respectively used to hang a plurality of independent initial blood bags; A plurality of flow controllers arranged side by side are respectively used to adjust the flow rates of a plurality of blood processing pipelines; A plurality of ultraviolet lamp boxes arranged side by side are respectively used to illuminate a plurality of blood treatment illumination panels; Shaker, used to shake the blood collection bag evenly, The initial blood bag is connected in sequence to the blood processing illumination plate and the blood collection bag through the blood processing pipeline.

2. The inactivation cabinet according to claim 1, characterized in that: The rocking table includes a long plate body and a bed body arranged on both sides of the long plate body. The bed body is arranged in multiple layers, and a bag of the blood collection bag is laid flat on each bed body. The bottom of the long plate body is driven by a first motor to cause both sides to swing horizontally in sequence.

3. The inactivation cabinet according to claim 1, characterized in that: The initial blood bags are sequentially hung on different hanging brackets, the flow controllers sequentially control different blood processing pipelines, and the ultraviolet lamp boxes sequentially irradiate different blood processing illumination panels with ultraviolet light.

4. The inactivation cabinet according to claim 1, characterized in that: The blood treatment illumination board is inserted into a clamping bracket, and the clamping bracket is arranged between two adjacent ultraviolet lamp boxes. The clamping bracket includes two brackets which are symmetrically arranged up and down and are respectively formed with clamping openings.

5. The inactivation cabinet according to claim 1, characterized in that: An indicator light is arranged on the top of the cabinet, a temperature sensor is arranged in the middle of the cabinet, and a temperature control system is arranged at the bottom and rear of the cabinet for adjusting the temperature inside the cabinet.

6. The inactivation cabinet according to claim 1, characterized in that: An air outlet is arranged above the hanging bracket, and an air return outlet is arranged inside the cabinet between the blood processing illumination panels.

7. The inactivation cabinet according to claim 1, characterized in that: A visual door panel is installed on the front of the cabinet, and the visual door panel is opened and closed by a magnetic door buckle.

8. The inactivation cabinet according to claim 1, characterized in that: The flow controller includes a second motor and a transmission shaft driven by the second motor through a gear, a plurality of circular sheets are fixedly sleeved on the transmission shaft in sequence, the circular sheets are engaged with grooves formed on the pump sheet, the pump sheet is arranged to move along the axis direction perpendicular to the axis of the transmission shaft, the axis of the circular sheet is located on one side of the axis of the transmission shaft, and the axis of the circular sheet is parallel to the axis of the transmission shaft, and the axes of the plurality of circular sheets are arranged in a ring shape around the axis of the transmission shaft in sequence, The second motor drives the transmission shaft to rotate, and then drives the circular plate body to rotate eccentrically, thereby driving the pump plate to move back and forth.

9. The inactivation cabinet according to claim 8, characterized in that: The pump plate is installed on a slot bracket, and the slot bracket forms a pipeline groove on the side of the pump plate away from the transmission shaft. The blood processing pipeline is placed in the pipeline groove, and the pump plate acts on the blood processing pipeline.

10. The inactivation cabinet according to claim 8, characterized in that: A switch rod is arranged on the outer side of the flow controller.

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