Probiotic in-situ planting device

Abstract

The invention provides a probiotic in-situ colonization device, which relates to the field of medical instruments, and comprises a bracket capable of being fixed on a duodenum bulb part; the stent membrane tube covers the stent; and the bearing strip is used for bearing probiotics and is connected with the stent membrane tube through a connecting membrane. The probiotic in-situ colonization device provided by the invention can position and retain the probiotics at a specified position, and the specific implementation mode can be adjusted according to a quality scheme to adjust the positioning position, so that a more personalized treatment scheme can be realized, and a new path is developed for gastrointestinal tract health management and disease treatment in the future.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a probiotic in-situ colonization device. Background Art

[0002] At present, research at home and abroad is mainly focused on solving the problem of probiotic colonization in the body through microcapsules, nanocarriers, and composite encapsulation. Despite this, the effectiveness of these dosage forms is often limited by the difficulty in achieving precise spatial distribution and maintaining long-term stability in the gastrointestinal tract. In addition, in many cases, the competitiveness of engineered probiotics with the original microbial communities in the host body is weak, and they often need to rely on antibiotics to eliminate the original microorganisms, which may lead to the risk of intestinal microecological imbalance. Summary of the invention

[0003] The purpose of the present invention includes providing a probiotic in-situ colonization device, which can overcome the problem in the prior art that the probiotic colonization position in the intestine cannot be accurately controlled.

[0004] The embodiments of the present invention can be implemented as follows:

[0005] In a first aspect, the present invention provides a probiotic in situ colonization device, comprising:

[0006] A stent that can be fixed to the duodenal bulb;

[0007] A stent membrane tube covering the stent;

[0008] A carrier strip for carrying probiotics, wherein the carrier strip is connected to the stent membrane tube via a connecting membrane.

[0009] In an optional embodiment, the supporting strip is in a tube shape or a belt shape.

[0010] In an optional embodiment, the probiotics are disposed in bacterial capsules.

[0011] In an optional embodiment, the bacterial capsule is coated with a mixed powder, and the mixed powder includes bacterial cells, a protective agent and gel particles.

[0012] In an optional embodiment, the protective agent includes at least one of a prebiotic and an antioxidant.

[0013] In an optional embodiment, more than two fungus capsules are arranged along the supporting strip, and the more than two fungus capsules are staggered.

[0014] In an optional embodiment, the surface of the bacterial cyst that can contact the chyme is streamlined;

[0015] And / or, a water absorption port is arranged on the surface of the fungus capsule.

[0016] In an optional embodiment, the load-bearing bar includes a degradation segment, and the degradation segment separates the load-bearing bar into two or more load-bearing segments.

[0017] In an optional embodiment, the supporting bar is further provided with a through hole.

[0018] In an optional embodiment, the connecting membrane is provided with a channel for chyme to pass through.

[0019] The beneficial effects of the probiotic in situ colonization device provided by the embodiment of the present invention include:

[0020] The present invention provides a probiotic in situ colonization device that can locate and retain probiotics at a specified location, and the specific implementation method can be adjusted according to the quality plan to adjust the positioning position, which is conducive to achieving a more personalized treatment plan and opening up a new path for future gastrointestinal health management and disease treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0022] Figure 1 A schematic structural diagram of the first probiotic in-situ colonization device provided in this application;

[0023] Figure 2 for Figure 1 A partial map of

[0024] Figure 3 This is a schematic diagram of the structure of a bracket in this application;

[0025] Figure 4 A schematic diagram of the structure of the second probiotic in situ colonization device provided in this application;

[0026] Figure 5 for Figure 4 A partial map of

[0027] Figure 6 A schematic diagram of a bacterial cyst arrangement method in this application;

[0028] Figure 7 This is a schematic diagram of the structure of a fungus capsule in this application;

[0029] Figure 8 A schematic diagram of the structure of the third probiotic in situ colonization device provided in this application;

[0030] Fig. 9 A schematic diagram of the structure of the fourth probiotic in situ colonization device provided in this application;

[0031] Fig.10 A schematic diagram of the structure of the fifth probiotic in situ colonization device provided in this application;

[0032] Fig.11 This is a schematic structural diagram of the first probiotic in situ colonization device provided in this application.

[0033] Marking instructions: 1- bracket; 2- bracket membrane tube; 3- connection membrane; 4- bearing strip; 5- degradation section; 6- bacterial capsule; 601- water absorption port; 602- mixed powder; 7- through hole. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

[0035] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0037] In the description of the present invention, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. appear to indicate an orientation or position relationship, they are based on the orientation or position relationship shown in the accompanying drawings, or are the orientation or position relationship in which the product of the invention is usually placed when used. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0038] In addition, the terms “first”, “second”, etc., if used, are merely used to distinguish between the descriptions and should not be understood as indicating or implying relative importance.

[0039] It should be noted that, in the absence of conflict, the features in the embodiments of the present invention may be combined with each other.

[0040] The embodiment of the present invention provides a probiotic in situ colonization device, such as Figure 1-5 As shown, including:

[0041] A stent 1 capable of being fixed to the duodenal bulb;

[0042] A stent membrane tube 2 covering the stent 1;

[0043] A carrier strip 4 for carrying probiotics, wherein the carrier strip 4 is connected to the stent membrane tube 2 via a connecting membrane 3 .

[0044] The present invention provides a probiotic in-situ colonization device, wherein the bracket 1 can be selected to be W-shaped, and an anchor thorn is fixed on the upper part of the bracket 1, which can be inserted into the duodenal bulb to fix the bracket 1, so as to provide a fixing force for the probiotic in-situ colonization device as a whole, so as to resist the impact force of chyme on the bacterial capsule 6, which is conducive to the precise positioning of the probiotic in-situ colonization device; the bracket membrane tube 2 can be selected to have a double-layer structure, covering all areas of the bracket 1 except the anchor thorn of the bracket 1, and the lower part is connected to the supporting strip 4 through the connecting film 3, which can provide the supporting strip 4 at the rear end with the connecting force with the bracket 1; by adjusting the length of the supporting strip 4, the bacterial species containing probiotics can be distributed in different parts of the intestine, so as to achieve the purpose of colonization of probiotics at designated positions in the intestine. Specifically, the type and carrying capacity of probiotics can be adjusted according to the specific situation of the individual, which is conducive to realizing a more personalized treatment plan and opening up a new path for future gastrointestinal health management and disease treatment.

[0045] When the probiotics carried on the carrying strip 4 are completely released or meet the requirements, the support 1, the carrying strip 4 and other structures can be taken out of the human body from the oral cavity together.

[0046] The present invention provides a probiotic in situ colonization device that can locate and retain probiotics at a specified location, and the specific implementation method can be adjusted according to the quality plan to adjust the positioning position, which is conducive to achieving a more personalized treatment plan and opening up a new path for future gastrointestinal health management and disease treatment.

[0047] In an optional embodiment, the supporting strip 4 is tubular or strip-shaped. The function of the supporting strip 4 is to fix the probiotics without affecting the contact between the probiotics and the chyme. Therefore, the supporting strip 4 can be set to be tubular or strip-shaped as needed.

[0048] It should be noted that when the support bar 4 is tubular, Figure 1-2 As shown, the probiotics are arranged on the inner wall of the support strip 4. The probiotics need to first pass through the inner wall of the support strip before being implanted on the intestinal wall. When the support strip 4 is in the shape of a strip, as shown in FIG. Figure 4-5As shown, the probiotics are arranged on the surface of the carrier strip 4, and the probiotics can directly contact the intestinal wall, which is more conducive to reducing the difficulty of probiotic colonization, so there will be differences in the quality effects of the two.

[0049] In an optional embodiment, the connecting membrane 3 is provided with a channel for chyme to pass through.

[0050] The support 1 is usually annular, and the chyme passes through the support 1 and the middle of the connecting membrane 3. Therefore, when the supporting strip 4 is strip-shaped, a channel for the chyme to pass through needs to be set on the connecting membrane 3 to transfer the chyme from the middle of the connecting membrane 3 to the outside of the supporting strip 4.

[0051] In an optional embodiment, the probiotics are disposed in a bacterial capsule 6 .

[0052] The probiotics are arranged in the bacterial capsule 6, which, on the one hand, is conducive to the accurate release of the probiotics at the designated position in the intestine and reduces the loss of probiotics during the implantation of the device; in addition, different types of probiotics can be arranged in different bacterial capsules 6 according to different treatment plans, thereby improving the flexibility of the device and helping to expand the application scenarios.

[0053] In an optional embodiment, the bacterial capsule 6 is coated with a mixed powder 602, and the mixed powder 602 includes bacterial cells, a protective agent and gel particles.

[0054] Protective agents can provide the nutrients needed by probiotics and the components needed to resist oxidative stress in the intestines, which is beneficial to improve the survival rate of probiotics, enable them to better adapt to and compete with the native intestinal microbial community, reduce the need to use antibiotics to eliminate the original microorganisms, and reduce the risk of drug resistance and intestinal microecological imbalance caused by the use of antibiotics.

[0055] The capsule wall of the bacterial capsule 6 can be made of a water-absorbing material, and the gel particles can also absorb water. The gel formed by absorbing water can wrap the bacterial powder of the probiotics, provide moisture for the colonization of the probiotics, and at the same time slow down the release rate of the probiotics, significantly increase the retention time of the probiotics, enhance its durability, and allow the probiotics to continue to play a health-promoting role for a longer period of time.

[0056] In an optional embodiment, the protective agent includes at least one of a prebiotic and an antioxidant.

[0057] In an optional embodiment, more than two fungus capsules 6 are arranged along the supporting strip 4, and the more than two fungus capsules 6 are staggered. Figure 6 shown.

[0058] One or more cysts 6 may be provided. When there are more than two cysts 6, adjacent cysts 6 are staggered in the direction of the carrier belt, which is beneficial to reduce the resistance of chyme passing through, reduce the load of the support 1, and also help avoid intestinal blockage. Specifically, in some embodiments, the cysts 6 on the carrier belt have two rows, which are arranged on the left and right sides of the carrier belt, and the cysts 6 in the left and right rows are staggered. Furthermore, the number of cysts 6 in the two rows is consistent, which is beneficial to balance the tension on the support 1.

[0059] In an optional embodiment, the surface of the bacterial capsule 6 that can contact the chyme is streamlined, such as Figure 7 shown.

[0060] The surface of the fungus cyst 6 that contacts the chyme is streamlined, which is beneficial to reducing the resistance encountered by the chyme passing through. In some embodiments, the surface of the fungus cyst 6 that contacts the chyme is ellipsoidal or teardrop-shaped.

[0061] In an optional embodiment, the surface of the fungus capsule 6 is provided with a water suction port 601, such as Figure 7 shown.

[0062] The bacterial capsule 6 is made of a water-absorbing material, such as PE material, which can transfer water molecules to meet the needs of the growth of internal probiotics and the water required by the gel, but its ability to transfer water is relatively weak. In some embodiments, in order to speed up the time when the device starts to work or speed up the release rate of probiotics, the surface of the bacterial capsule 6 can also be provided with a water suction port 601. Generally, the water suction port 601 is set on the surface of the bacterial capsule 6 that can contact the chyme to absorb water in the chyme. In some embodiments, the water suction port 601 can also be set on the supporting strip, which can absorb water and facilitate the probiotics to pass through the supporting strip and be implanted on the intestinal wall.

[0063] It should be noted that the diameter of the water suction port 601 is designed to not allow gel particles to pass through, but to allow water molecules and bacteria to pass through.

[0064] In an optional embodiment, the load-bearing bar 4 includes a degradation section 5, and the degradation section 5 divides the load-bearing bar 4 into two or more load-bearing sections, such as Figure 8-11 shown.

[0065] The degradation section 5 can be set to start degrading after a specified time after entering the human intestine, or to degrade under specified conditions such as pH conditions. After the degradation zone is degraded, the part of the degradation zone away from the support 1 is detached and can move along the intestine with the chyme while continuing to slowly release probiotics until it is finally discharged from the body through the anus.

[0066] It should be noted that the shape of the degradation zone is related to the shape of the load-bearing bar 4. If the load-bearing bar 4 is tubular, the degradation zone and the load-bearing section are both tubular, or if the load-bearing bar 4 is strip-shaped, the degradation zone can be linear or rectangular or any other shape that can separate the load-bearing section. The connection between the degradation zone and the load-bearing section can be welding or other methods.

[0067] In an optional embodiment, a through hole 7 is further provided on the supporting bar 4 .

[0068] When the support strip 4 is tubular, a through hole 7 can be provided on the support strip 4 so that part of the chyme can pass through the through hole 7, which is beneficial for the probiotics to pass through the support strip and colonize in the inner wall of the intestine, and is also beneficial for improving the intestinal absorption of nutrients in the chyme.

[0069] The above description is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by a technician familiar with the technical field within the technical scope disclosed by the present invention should be covered by the protection scope of the present invention.

Claims

1. A probiotic in situ colonization device, characterized in that: include: A stent that can be fixed to the duodenal bulb; A stent membrane tube covering the stent; A carrier strip for carrying probiotics, wherein the carrier strip is connected to the stent membrane tube via a connecting membrane.

2. The probiotic in situ colonization device according to claim 1, characterized in that: The supporting strip is in a tube shape or a belt shape.

3. The probiotic in situ colonization device according to claim 1, characterized in that: The probiotics are arranged in bacterial capsules.

4. The probiotic in situ colonization device according to claim 3, characterized in that: The fungus capsule is coated with mixed powder, and the mixed powder comprises fungus bodies, protective agents and gel particles.

5. The probiotic in situ colonization device according to claim 4, characterized in that: The protective agent includes at least one of a prebiotic and an antioxidant.

6. The probiotic in situ colonization device according to claim 3, characterized in that: More than two fungus capsules are arranged along the supporting strip, and the more than two fungus capsules are arranged in a staggered manner.

7. The probiotic in situ implantation device according to claim 3, characterized in that: The surface of the bacterial cyst that can contact the chyme is streamlined; And / or, a water absorption port is arranged on the surface of the fungus capsule.

8. The probiotic in situ implantation device according to claim 1, characterized in that: The load-bearing bar includes a degradation segment, and the degradation segment divides the load-bearing bar into two or more load-bearing segments.

9. The probiotic in situ colonization device according to claim 1, characterized in that: The bearing bar is also provided with a through hole.

10. The probiotic in situ colonization device according to claim 2, characterized in that: The connecting membrane is provided with a channel for chyme to pass through.

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