Target alignment device and neutron capture treatment system

Abstract

The present application provides a target alignment device and a neutron capture therapy system, the target alignment device comprising: a target assembly having a target center; the supporting device is used for supporting the target assembly; the positioning device is arranged on the supporting device, the positioning device can move relative to the supporting device so as to be used for positioning the target assembly to a target position, and at the target position, the target center is located in a preset range with the supporting device as the reference. According to the positioning device in the embodiment of the invention, the target center of the target assembly can be positioned to the same position as the target center of the previous target assembly, so that the neutron beam of the neutron capture treatment system is in a stable state, meanwhile, the positioning device is simple in structure and low in failure rate, and unnecessary radiation of operators can be reduced.

Description

Technical Field

[0001] The present application relates to the field of target alignment devices, and in particular to a neutron capture therapy system. Background Art

[0002] The description in this section merely provides background information related to the disclosure of the present application and does not constitute prior art.

[0003] With the development of atomic science, radiation therapy such as cobalt-60, linear accelerator, and electron beam has become one of the main means of cancer treatment. However, traditional photon or electron therapy is limited by the physical conditions of radiation itself. While killing tumor cells, it will also cause damage to a large number of normal tissues along the beam path. In addition, due to the different sensitivity of tumor cells to radiation, traditional radiotherapy is often not effective in treating malignant tumors that are more resistant to radiation (such as glioblastoma multiforme and melanoma).

[0004] In order to reduce radiation damage to normal tissues around tumors, the concept of targeted therapy in chemotherapy has been applied to radiotherapy; and for tumor cells with high radiation resistance, radiation sources with high relative biological effectiveness (RBE) are currently being actively developed, such as proton therapy, heavy particle therapy, neutron capture therapy, etc. Among them, neutron capture therapy is a combination of the above two concepts, such as boron neutron capture therapy, which provides a better cancer treatment option than traditional radiation by specifically aggregating boron-containing drugs in tumor cells and coordinating precise neutron beam control.

[0005] In the neutron capture therapy system, the charged particle beam is accelerated by an accelerator to an energy sufficient to overcome the Coulomb repulsion of the target nuclei in the beam shaper, and a nuclear reaction occurs with the target to produce neutrons, which are suitable for treatment after being adjusted by the beam shaper (BSA) energy spectrum. Therefore, in the process of generating neutrons, the target will be irradiated by the high-power accelerated charged particle beam, and the temperature of the target will rise significantly, thereby affecting the service life of the target.

[0006] It should be noted that the above introduction to the technical background is only for the convenience of providing a clear and complete description of the technical solutions of the present application and for the convenience of understanding by those skilled in the art. It cannot be considered that the above technical solutions are well known to those skilled in the art simply because they are described in the background technology section of the present application. Summary of the invention

[0007] The inventors have conducted repeated tests and creatively discovered that after each replacement of the target material, the performance of the neutron capture therapy system in the prior art has certain defects, including but not limited to inconsistent or unstable neutron beams. In order to find out the cause of the defect, the inventors have conducted repeated tests and creatively discovered that the cause of the defect is that there is a certain deviation between the position of the target material after each installation compared to the position of the previous target material. This deviation further causes the position of the target material relative to the charged particle beam and / or the beam shaper to be offset compared to before, thereby causing the above-mentioned defect.

[0008] Based on the above-mentioned defects of the prior art, the target alignment device and the neutron capture therapy system in the present application are used to solve the technical problem of inconsistent or unstable neutron flux of the neutron beam of the neutron capture therapy system in the prior art.

[0009] In order to achieve the above objectives, the present application provides a target alignment device, comprising:

[0010] a target assembly having a target center;

[0011] A supporting device, used for supporting the target assembly;

[0012] A positioning device is arranged on the supporting device, and the positioning device can move relative to the supporting device, so as to position the target assembly to a target position, wherein at the target position, the target center is located within a preset range based on the supporting device.

[0013] Preferably, the target assembly comprises a target body and a target accessory disposed on the periphery of the target body, and the positioning device is used to support the target body and / or the target accessory to position the target assembly to the target position.

[0014] Preferably, the positioning device is used to support the target body, and the positioning device is in conflict with the target body.

[0015] Preferably, the positioning device extends from between the target attachment and the outer periphery of the target body and contacts the target body to support the surface of the target body; and / or,

[0016] The target attachment is configured to have a spacing space, and the positioning device extends from the spacing space into and abuts against the target body to position the target body.

[0017] Preferably, the target accessory comprises a limiting portion arranged on the periphery of the target body, and a cooling pipe passing through the limiting portion;

[0018] The positioning device is supported on the limiting portion to position the target assembly.

[0019] Preferably, the positioning device comprises a moving unit and a carrying unit, and the moving unit drives the carrying unit so that the carrying unit supports the target assembly.

[0020] Preferably, the carrying unit has a contoured portion, the target assembly has a fitting surface, and the contoured portion can fit with the fitting surface, so that the carrying unit supports the target assembly.

[0021] Preferably, the number of the carrying units is at least two, one of the carrying units supports the target assembly along a first direction, and the other carrying unit supports the target assembly along a second direction, and an angle between the first direction and the second direction is greater than or equal to 0 degree and less than or equal to 180 degrees.

[0022] Preferably, the positioning device comprises:

[0023] at least one motion unit, the motion unit having a first pivot center, the motion unit being configured to pivot about the first pivot center;

[0024] At least one bearing unit, the bearing mechanism is arranged at one end of the motion unit;

[0025] The first pivot center is configured to be movable in a direction close to the center of the target material to away from the center of the target body, so that the supporting unit is driven by the moving unit to move from a position away from the surface of the target assembly to a position in contact with the surface of the target assembly to support the surface of the target assembly.

[0026] Preferably, the positioning device further comprises a first guide portion, the first guide portion is arranged to extend in a direction away from the center of the target assembly to close to the center of the target assembly, and the first pivot center is arranged to move along the first guide portion.

[0027] Preferably, the moving unit also has a second pivot center, which is arranged on the moving unit and located between the first pivot center and the carrying unit, and the moving unit is configured to pivot around the second pivot center, and the second pivot center is configured to move in a direction away from the center of the target assembly to close to the center of the target assembly.

[0028] Preferably, the positioning device further comprises a second guide portion, the second guide portion is arranged to extend in a direction away from the center of the target assembly to close to the center of the target assembly, and the second pivot center is arranged to move along the second guide portion.

[0029] A second aspect of the present application provides a neutron capture therapy system, comprising:

[0030] A charged particle beam generating device, used for outputting a charged particle beam;

[0031] a target assembly for reacting with the charged particle beam to produce a neutron beam;

[0032] A conveying device, used to drive the target assembly to move to a predetermined position;

[0033] A positioning device, wherein the positioning device can interfere with the target assembly, and the positioning device is used to place the target assembly at a target position after the conveying device places the target assembly at a predetermined position.

[0034] Preferably, the target assembly comprises a target body and a target accessory disposed on the periphery of the target body, the positioning device is used to support the target body, and the positioning device is in conflict with the target body.

[0035] Preferably, the neutron capture therapy system further comprises:

[0036] A beam shaper, used for shaping the neutron beam;

[0037] The beam shaping body can be used to accommodate at least part of the target assembly, and the target assembly also includes a target material arranged in one end of the target body, and the end of the target body provided with the target material is accommodated in the beam shaping body, and the positioning device is used to position the end of the target body away from the target material.

[0038] Preferably, it further comprises a beam shaping body, and after the target assembly moves to a predetermined position, the end of the target assembly generating the neutron beam abuts against the beam shaping body.

[0039] Beneficial effects:

[0040] By means of the above technical scheme, the target alignment device of the present application can position the target center of the target assembly to a preset range relative to the target center of one or more target assemblies that were previously targeted to generate the target beam, and within the preset range, the target center of the target assembly is at the target position, and the target position makes the target center at the same position corresponding to other structures in the beam system, so that multiple target assemblies can be positioned at the target position, so that the position of the target assembly after the target material is exhausted and the target is replaced is at the same position relative to other structures in the beam system. By ensuring that the target alignment device makes the target center at the target position, the target assembly is at the target position relative to the charged particle beam generating device and other structures in the neutron capture therapy system, and the target position makes the center of the target assembly at the same relative position relative to the charged particle beam generating device and other structures in the neutron capture therapy system after the target material is exhausted and the target is replaced, thereby ensuring that the neutron beam of the neutron capture therapy system is in a stable state. At the same time, the positioning device has a simple structure and a low failure rate, and can reduce unnecessary radiation of operators.

[0041] With reference to the following description and accompanying drawings, the specific embodiments of the present application are disclosed in detail, indicating the way in which the principles of the present application can be adopted. It should be understood that the embodiments of the present application are not therefore limited in scope. Within the scope of the spirit and clauses of the appended claims, the embodiments of the present application include many changes, modifications and equivalents.

[0042] Features described and / or illustrated with respect to one embodiment may be used in the same or similar manner in one or more other embodiments, combined with features in other embodiments, or substituted for features in other embodiments.

[0043] It should be emphasized that the term “include / comprising” when used herein refers to the presence of features, integers, steps or components, but does not exclude the presence or addition of one or more other features, integers, steps or components. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] The drawings described herein are for explanation purposes only and are not intended to limit the scope of the present application in any way. In addition, the shapes and proportional dimensions of the components in the drawings are only for illustration purposes and are used to help understand the present application. They do not specifically limit the shapes and proportional dimensions of the components of the present application. Under the guidance of the present application, those skilled in the art can select various possible shapes and proportional dimensions to implement the present application according to specific circumstances. In the drawings:

[0045] Figure 1 A schematic plan view of a neutron capture therapy system provided in one embodiment of the present invention.

[0046] Figure 2A three-dimensional schematic diagram of a neutron capture therapy system provided by an embodiment of the present invention.

[0047] Figure 3 A schematic structural diagram of a target assembly and a conveying device provided in one embodiment of the present invention.

[0048] Figure 4 A schematic structural diagram of a target alignment device provided by an embodiment of the present invention from a first viewing angle.

[0049] Figure 5 A schematic structural diagram of a target alignment device provided by an embodiment of the present invention from a second viewing angle.

[0050] Figure 6 A schematic structural diagram of a positioning device provided in one embodiment of the present invention.

[0051] Figure 7 This is a simplified structural schematic diagram of the positioning device and the target body in a clamping state provided by the first embodiment of the present invention.

[0052] Figure 8 This is a simplified structural schematic diagram of a positioning device provided in the second embodiment of the present invention in a clamping state for a target body.

[0053] Fig. 9 This is a simplified structural schematic diagram of the positioning device provided in the third embodiment of the present invention in a clamping state for the target body.

[0054] Fig.10 This is a simplified structural schematic diagram of a positioning device provided in a fourth embodiment of the present invention in a clamping state for a target body.

[0055] Fig.11 This is a simplified structural diagram of a positioning device provided in a fifth embodiment of the present invention in a clamping state for a target body.

[0056] Fig.12 This is a simplified structural schematic diagram of a positioning device provided in a sixth embodiment of the present invention in a clamping state for a target body.

[0057] Fig.13 This is a simplified structural schematic diagram of the positioning device provided in the seventh embodiment of the present invention in a clamping state for the target body.

[0058] The figure numbers of the above drawings are: 1, charged particle beam generating device; 11, accelerator; 12, transmission device; 2, target assembly; 21, target body; 211, fixing part; 212, neck; 213, extension part; 214, extension part; 215, target material; 23, target accessories; 231, cooling pipe; 232, detection device; 233, limit part; 3, conveying device; 31, driving frame; 32, power structure; 4, positioning device; 41, driving unit; 411, output end; 42, moving unit; 421, first connecting rod; 422, second connecting rod; 423, first pivot center; 424, second pivot center; 425, first guide groove; 426, second guide groove; 427, first guide groove; 428, second guide groove; 429, first guide groove; 430, first guide groove; 431, second guide groove; 432, second guide groove; 433, first guide groove; 434, second guide groove; 435, first guide groove; 436, first guide groove; 437, second guide groove; 438, first guide groove; 439, first guide groove; 440, second guide groove; 441, first guide groove; 442, second guide groove; 443, first guide groove; 444, second guide groove; 445, first guide groove; 446, second guide groove; 447, first guide groove; 448, second guide groove; 449, first guide groove; 450, first guide groove; 451, first guide groove; 452, second guide groove; 453, first guide groove; 454, second guide groove; 455, first guide groove; 456, first guide groove; 457, first guide groove; 458, first guide groove; 45 6. Second guide groove; 4261. Slope section; 43. Bearing unit; 431. First bearing member; 432. Second bearing member; 433. Rolling portion; 44. Mounting bracket; 45. Guide mechanism; 451. Limit plate; 452. Limit groove; 453. Positioning pin; 5. Beam shaping body; 6. Support device; 61. Track; 62. Support column; 7. Shielding facility; 71. Shielding door; 72. First opening; 73. Second opening; M. Target center; R1. First space; R2. Second space; R3. Third space; W. Angle; X. First center axis; Y. Second center axis; T1. First direction; T2. Second direction; Z. Gap. DETAILED DESCRIPTION

[0059] In order to enable those skilled in the art to better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of this application.

[0060] It should be noted that when an element is referred to as being "disposed on" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only and are not intended to be the only embodiment.

[0061] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0062] Each embodiment in this specification is described in a progressive manner, and the same or similar parts between the embodiments can be referred to each other, and each embodiment focuses on the differences from other embodiments. In particular, for the system embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and the relevant parts can be referred to the partial description of the method embodiment.

[0063] It should be noted that, in the description of this application, the terms "first", "second", etc. are only used for descriptive purposes and to distinguish similar objects. There is no order of precedence between the two, and they cannot be understood as indicating or implying relative importance. In addition, in the description of this application, unless otherwise specified, the inclusive meaning of "plurality" is two or more.

[0064] Neutron capture therapy has been increasingly used in recent years as an effective means of treating cancer, among which boron neutron capture therapy is the most common. Neutrons for boron neutron capture therapy can be supplied by a nuclear reactor or an accelerator 11. The embodiment of the present application takes the boron neutron capture therapy of the accelerator 11 as an example. The basic components of the boron neutron capture therapy of the accelerator 11 generally include an accelerator 11 for accelerating a charged particle beam (such as protons, deuterons, etc.), a radioactive consumable target material 215, a heat removal system, and a beam shaper 5. The accelerated charged particle beam reacts with the metal target material 215 to produce neutrons, and a suitable nuclear reaction is selected based on the required neutron yield and energy, the energy and current of the accelerated charged particle beam that can be provided, the physical and chemical properties of the metal target material 215, and other characteristics. Commonly discussed nuclear reactions include: 7 Li(p,n) 7 Be and 9 Be(p,n) 9 B, both reactions are endothermic reactions, and the energy thresholds of the two nuclear reactions are 1.881MeV and 2.055MeV, respectively. Since the ideal neutron source for boron neutron capture therapy is epithermal neutrons at the keV energy level, theoretically, if protons with energy only slightly higher than the threshold are used to bombard the metal lithium target 215, relatively low-energy neutrons can be produced, which can be used clinically without much slowing down treatment. However, the cross-sections of the two targets 215 of lithium metal (Li) and beryllium metal (Be) with protons of the threshold energy are not high. In order to produce a sufficiently large neutron flux, protons with higher energy are usually selected to induce nuclear reactions.

[0065] The ideal radioactive consumable target material 215 should have high neutron yield, neutron energy distribution close to the epithermal neutron energy zone (described in detail below), no too much strong penetrating radiation, safe, cheap, easy to operate, and high temperature resistance, but in fact it is impossible to find a nuclear reaction that meets all the requirements. In the embodiment of the present application, a target material 215 made of lithium metal is used. However, it is well known to those skilled in the art that the material of the target material 215 can also be made of other metal materials besides the metal materials mentioned above.

[0066] The requirements for heat removal systems vary depending on the nuclear reaction selected, such as 7 Li(p,n) 7 Because the melting point and thermal conductivity of the metal target 215 (lithium metal) are poor, the requirements for the heat removal system are higher. 9 Be(p,n) 9 B is high. In the embodiments of the present application, 7 Li(p,n) 7 Nuclear reaction of Be. It can be seen that the temperature of the target material 215 irradiated by the accelerated charged particle beam of high energy level will inevitably rise significantly, thereby affecting the service life of the target material 215.

[0067] Therefore, the neutron capture therapy system, which belongs to the radioactive ray irradiation system, must have the problem of replacing the radioactive consumable target material 215. The neutron capture therapy system in the embodiment of the present application can keep the target material 215 in the same position after each replacement of the target material 215, so as to ensure that the neutron beam of the neutron capture therapy system is in a stable state. Therefore, the neutron capture therapy system can also be always in a relatively stable or better working state.

[0068] Figure 1 Schematic diagram of a neutron capture therapy system according to an embodiment of the present invention. Figure 2 is a three-dimensional schematic diagram of a neutron capture therapy system provided according to an embodiment of the present invention. Figure 1 and Figure 2As shown, the neutron capture therapy system may include a charged particle beam generator 1, a target assembly 2 and a beam shaper 5 (BSA). The charged particle beam generator 1 may include an accelerator 11 for generating a charged particle beam and a transmission device 12 for transmitting the charged particle beam. The transmission direction of the charged particle beam is consistent or substantially consistent with the arrangement direction of the transmission device 12. In this embodiment, the target assembly 2 may include a target body 21 whose extension direction is consistent or substantially consistent with the transmission device 12. The target body 21 has a first end and a second end opposite to each other along its extension direction. The first end of the target body 21 can be engaged with or disengaged from the transmission device 12. When the target body 21 and the transmission device 12 are in an engaged state, the charged particle beam output by the transmission device 12 can enter the target body 21 from the first end of the target body 21, and then reach the target material 215. The target material 215 is arranged at the second end of the target body 21. The target material 215 can react with the charged particle beam to generate a neutron beam.

[0069] In this embodiment, the cross-sectional projection of the target 215 perpendicular to the extension direction of the target body 21 is circular, square or other symmetrical shapes. The target center M of the target assembly 2 may be the symmetric center point or symmetric center axis of the target 215. Of course, in other optional embodiments, the cross-sectional projection of the target 215 perpendicular to the extension direction of the target body 21 may not be a symmetrical shape. In this case, the target center M of the target assembly 2 may also be a point or axis defined artificially on the projected cross section of the target 215. Of course, in other optional embodiments, the target center M of the target assembly 2 may also be set based on the target body 21 or other rigid components or asymmetric components in the target assembly 2 that have a symmetric center.

[0070] Combination Figure 1 and Figure 2 As shown, the neutron capture therapy system can be divided into a first space R1 and a second space R2 based on a shielding facility 7 with an opening and closing function. The shielding facility 7 may include two shielding doors 71 that can move relative to each other. When the two shielding doors 71 are in a closed state, the shielding facility 7 may form at least one first opening 72 for the target assembly 2 and part of the transmission device 12 to pass through. In this embodiment, the first opening 72 is arranged at the transmission device 12, and the first opening 72 is adapted to the shape of the outer wall of the transmission device 12 passing through the first opening 72, including but not limited to circular, elliptical, diamond, square, irregular and other shapes. Of course, in another optional embodiment, the first opening 72 is arranged at the transmission device 12, and the first opening 72 is adapted to the shape of the outer wall of the transmission device 12 passing through the first opening 72, including but not limited to circular, elliptical, diamond, square, irregular and other shapes.

[0071] An accelerator 11 is disposed in the first space R1. A beam shaper 5 is disposed in the second space R2. When the neutron capture therapy system is in a radiotherapy state, the first end of the target body 21 is in a joint state with the transmission device 12. At this time, the target body 21 is located in the second space R2. The transmission device 12 can transmit the charged particle beam accelerated by the accelerator 11 from the first space R1 to the target material 215 in the second space R2. The accelerator 11 accelerates the charged particle beam to an energy sufficient to overcome the Coulomb repulsion of the nuclei of the target material 215 and interacts with the target material 215. 7 Li(p,n) 7 Be nuclear reaction produces neutrons, and the neutrons form neutron beams and are emitted from the beam outlet of the beam shaping body 5. The beam shaping body 5 is usually large in size and is embedded in the wall, including a retarder, a thermal neutron absorber, a radiation shield, etc. (not shown in the drawings). The retarder is usually made of aluminum fluoride and one or more mixed materials selected from lithium fluoride, aluminum, lead fluoride, aluminum oxide, calcium fluoride or magnesium fluoride. Some of these materials are relatively brittle, so the requirements for the addition and installation process are relatively high. It slows down the neutrons generated from the target material 215 to the epithermal neutron energy zone, and the deviated neutrons are guided back to the retarder by the reflector to increase the epithermal neutron beam intensity. The thermal neutron absorber absorbs the thermal neutrons to avoid unnecessary damage to the shallow normal tissues due to excessive doses during treatment; the radiation shield is used to shield the leaked neutrons and photons to reduce the normal tissue dose in the non-irradiated area. The neutron capture therapy system further includes a third space R3 as an irradiation chamber, and a neutron beam that meets the conditions can be emitted from the beam outlet and enter the irradiation chamber for use.

[0072] When the target assembly 2 (target material 215) needs to be replaced, for example, when the usage time reaches a certain length of time, or the number of times of use reaches a certain number of times, or the target material 215 fails, etc., at this time, it is necessary to open the shielding facility 7, separate the target body 21 of the target assembly 2 from the transmission device 12, and then move the target assembly 2 to be replaced from the second space R2 to the first space R1 for recycling, and then transfer the new target assembly 2 from the first space R1 to the second space R2, and then connect the target body 21 and the transmission device 12, and close the shielding facility 7. In the process of replacing the target assembly 2, the transmission device 12 and the target assembly 2 are preferably kept in a vacuum state.

[0073] Taking radiation contamination into consideration, it is generally necessary to set up a conveying device 3, which can transfer the target assembly 2 (for example, the target assembly 2 that needs to be replaced) from the second space R2 to the first space R1, and can also transfer the target assembly 2 (for example, a new target assembly 2) from the second space R2 to the first space R1.

[0074] In this embodiment, when the two shielding doors 71 are in a closed state, the shielding facility 7 can form a second opening 73. The neutron capture therapy system can also include a support device 6 for supporting the target assembly 2. The support device 6 can include a track 61 passing through the second opening 73. The conveying device 3 can include a drive frame 31 and a power structure 32 arranged on the track 61 and used to carry the target assembly 2. The power structure 32 includes but is not limited to electronic or pneumatic connecting rods, robots and their structures, mechanical arms, etc. On the one hand, the track 61 of the support device 6 plays a certain role in limiting and pre-positioning the target assembly 2. However, considering that the track 61 and the drive frame 31 can move relative to each other. Due to the need for relative movement, the matching mode between the track 61 and the drive frame 31 is preferably a gap Z match. This matching mode ensures the smoothness of the relative movement between the track 61 and the drive frame 31, and also maximizes the accuracy of the pre-positioning of the target assembly 2 by the conveying device 3. The track 61 provides a supporting surface for supporting the driving frame 31. On this supporting surface, the machining shape and position errors of the matching parts between the driving frame 31 and the supporting surface, the machining shape and position errors of the supporting surface itself, and the shape and position errors caused by the assembly of the support frame 31 and the supporting surface, together affect the position of the driving frame 31 after being supported, that is, the position of the target assembly 2 carried by the driving frame 31, resulting in a certain deviation between the position of the target assembly 2 and the previous position of the target assembly 2 after each target change and installation.

[0075] Combination Figure 1As shown, in order to overcome this deviation, that is, to minimize the adverse effects of the deviation, the neutron capture therapy system may also include a positioning device 4. The positioning device 4 is used to position the target center M of the target assembly 2 at the target position after the conveying device 3 places the target assembly 2 at the predetermined position. The target position makes the target assembly 2 at the same position corresponding to other structures in the beam system, so that multiple target assemblies 2 can be positioned to the target position, so that the position of the target assembly 2 after the target material 215 is exhausted and the target is replaced and re-mounted is in the same corresponding position relative to other structures in the beam system, thereby ensuring that the neutron beam generated by the target assembly 2 is consistent with the neutron beam generated by the previous target assembly 2 after each target replacement and re-mounting, ensuring the stability of the neutron beam. In this embodiment, the predetermined position can be the end position of the action of the conveying device 3 when the conveying device 3 transfers the target assembly 2 (for example, the target assembly 2 that needs to be replaced) from the second space R2 to the first space R1. That is, the positioning device 4 starts to operate when the conveying device 3 transfers the target assembly 2 to the terminal position of the first space R1 (at this time, the second end of the target assembly 2 can be in contact with the beam shaping body 5, or, in other optional embodiments, the target material 215 of the target assembly 2 is located in the beam shaping body 5), and then positions the target assembly 2 until the target center M of the target assembly 2 is positioned to the same position as the target center M of the previous target assembly 2. Generally, the conveying device 12 can be connected to the target body 21 after the positioning device 4 positions the target center M of the target assembly 2 at the target position. Of course, in other optional embodiments, when the conveying device 3 transfers the target assembly 2 to the terminal position of the first space R1, the conveying device 12 can also be connected to the target body 21 first, and then the positioning device 4 starts to operate, so as to position the target assembly 2.

[0076] It can be understood that, in other optional embodiments, the predetermined position can be the intermediate position of the transport after the transport device 3 transfers the target assembly 2 (for example, the target assembly 2 that needs to be replaced) from the second space R2 to the first space R1. That is, in the range between the distance from the transport device 3 to the termination position after the target assembly 2 is transferred to the first space R1, the positioning device 4 starts to act to position the target assembly 2. During the transportation of the target assembly 2 by the transport device 3, the positioning device 4 can keep the target center M of the target assembly 2 at the corresponding position to the target position. After the transport of the transport device 3 is terminated, the positioning device 4 can position the target center M of the target assembly 2 to the target position, that is, the same position as the target center M of the previous target assembly 2. In other words, the positioning device 4 is used to make the target assembly 2 be located at the same position after replacement compared to before replacement after the transport device 3 places the target assembly 2 in the predetermined position. Preferably, the target assembly 2 or the target body 21 has a uniform surface. When the conveying device 3 pushes the target assembly 2 from the preset position to the target position, the positioning device 4 can adaptively adapt to the uniform surface to realize the positioning of the target assembly 2 at the target position, and ensure that after each target change and re-targeting, the position of the target assembly 2 is in the same position relative to the charged particle beam generating device 1 and other structures, so that the generated neutron beam is consistent with the neutron beam generated by the previous target assembly 2, and the stability of the neutron beam is ensured. In other optional embodiments, the target assembly 2 or the target body 21 may also have a non-uniform surface such as an inclined surface, a conical portion, etc., and the positioning device 4 may also adaptively adapt to the non-uniform surface, as long as it is ensured that the target assembly 2 is in the same (corresponding) position compared to the target assembly 2 that was previously targeted each time after being fixed.

[0077] Combination Figure 3 and Figure 5 As shown, in this embodiment, the driving frame 31 of the conveying device 3 can be sleeved on the outer peripheral side of the target body 21. When the target assembly 2 is recovered or reinstalled, the conveying device 3 is recovered or reinstalled synchronously with the target assembly 2. The first end of the target body 21 has an extension portion 214 extending out of the driving frame 31. The extension portion 214 is detachably connected to the transmission device 12, for example, the detachable connection can be achieved through a quick clamp structure, a connecting rod, a lock, a concave-convex buckle and other structures. In another optional embodiment, the conveying device 3 and the transmission device 12 are detachably connected, for example, the detachable connection can be achieved through a quick clamp structure, a connecting rod, a lock, a concave-convex buckle and other structures. When the conveying device 3 and the transmission device 12 are connected, the transmission device 12 can be docked with the first end of the target body 21 or inserted into each other to achieve the communication and connection between the channel of the transmission device 12 and the channel of the target body 21.

[0078] Combination Figure 5As shown, in this embodiment, the target body 21 includes a fixing portion 211 penetrating the driving frame 31, an extension portion 213 provided with a target material 215, and a neck portion 212 located between the fixing portion 211 and the extension portion 213 along the extension direction of the target body 21. Compared with the fixing portion 211 and the extension portion 213, the projection area of ​​the neck portion 212 in the cross-sectional projection perpendicular to the extension direction of the target body 21 is the smallest. The extension portion 213, the neck portion 212 and the fixing portion 211 can be an integrated structure, or can be set to be detachably connected or fixedly connected according to actual needs.

[0079] Combination Figure 3 As shown, generally speaking, a target attachment 23 is provided on the periphery of the target body 21. Therefore, in order to allow the positioning device 4 to have a larger activity space, the positioning device 4 can position and support the portion with a smaller outer diameter in the target body 21 (for example, the neck 212 of the target assembly 2). In other optional embodiments, the positioning device 4 can also position the minimum diameter of the target body 21 or other positions that are convenient for clamping as needed.

[0080] In order to minimize the influence of the radiation generated during the target material 215 shooting process on the positioning device 4, the positioning device 4 can be used to position the end of the target body 21 away from the target material 215. In other words, the positioning position of the target assembly 2 by the positioning device 4 can be as close as possible to the first end of the target body 21 and the transmission device 12. In other optional embodiments, the positioning position of the positioning device 4 can also be located at any position between the first end of the target body 21 and the second end of the target body 21. Preferably, a large distance needs to be maintained between the positioning position and the target material 215. In other optional embodiments, the positioning position of the target assembly 2 by the positioning device 4 can also be set according to actual needs. For example, the positioning position of the target assembly 2 by the positioning device 4 needs to be located outside the beam shaping body 5.

[0081] Main reference Figure 4 and Figure 5 As shown, the embodiment of the present application also discloses a target alignment device, which includes a target assembly 2, a support device 6 and a positioning device 4. Figure 3As shown, the target assembly 2 may include a target body 21, a target material 215 disposed at one end of the target body 21, and a target accessory 23 disposed at the periphery of the target assembly 2. The target accessory 23 includes but is not limited to a cooling pipe 231 for contacting the target material 215 and a detection device 232 capable of detection. The cooling pipe 231 may be connected to an external cooling system, and the temperature of the target material 215 increases and generates heat due to accelerated irradiation of a high energy level, and the target material 215 is efficiently cooled by the cooling medium flowing through the cooling pipe 231. The detection device 232 includes but is not limited to a temperature sensor for detecting the real-time temperature of the cooling device, a vacuum sensor for detecting the hollow inside of the target body 21, and a neutron detector for detecting the neutrons generated after a nuclear reaction occurs. The detection device 232 includes but is not limited to an electronic sensor, a proximity sensor, a capacitive sensor, a transducer or other forms of sensors. The target center M of the target assembly 2 may be the symmetry center point or symmetry center axis of the target material 215. Of course, in other optional embodiments, the target center M of the target assembly 2 can also be set based on the target body 21 or other rigid components with a symmetry center in the target assembly 2. For example, in some embodiments, the target center M is set based on the axis of the cylindrical contour portion included in the target body 21. In this case, the target center M can be defined as the intersection of the target material 215 and the cylindrical axis. In other embodiments, the target center M can be set based on the symmetry axis of the cooling pipe 231, and the target center M is defined as the intersection of the symmetry axis of the cooling pipe 231. The present invention is not limited to this, so as to realize the position calibration of the target assembly 2, and to facilitate the placement of the target material 215 in a position that matches the charged particle beam and the beam shaper 5.

[0082] More than 90% (by weight) of the material of the irradiated part of the positioning device 4 and the supporting device 6 is composed of at least one of C, H, O, N, Si, Al, Mg, Li, B, Mn, Cu, Zn, S, Ca, and Ti. In this embodiment, if the positioning device 4 and the supporting device 6 are selected from aluminum alloy, the half-life of aluminum after neutron activation is short, only 2.2 minutes; while the iron, cobalt, nickel and other elements rich in traditional steel materials have a long half-life after neutron activation, such as the half-life of cobalt 60 is 5.27 years; the use of aluminum alloy greatly reduces the radioactivity derived from neutron activation within a limited time, in addition to reasonably suppressing the dose caused by secondary radiation, it is more conducive to the future removal of equipment. The material of the positioning device 4 and the supporting device 6 can further be aluminum-magnesium alloy, or carbon fiber composite material, glass fiber composite material or a combination thereof.

[0083] Reference Figure 1 and Figure 4 As shown, as mentioned above, the support device 6 may include a track 61 whose extension direction is parallel or substantially parallel to the transmission direction of the charged particle beam. The support device 6 may also include a support column 62 disposed in the second space R2. One end ( Figure 1 The lower end of the support column 62 is fixed to the ground, and the other end of the support column 62 ( Figure 1 The support column 62 may be fixedly connected to the track 61 to support the track 61. The support column 62 may also be arranged at other positions, such as in the first space R1 R2, in which case the rigidity of the track 61 may be increased to achieve reliable support of the track 61 by the support column 62. The support column 62 may also be arranged at other positions to achieve stable support of the track 61.

[0084] In this embodiment, the target alignment device can position the target center M of the target assembly 2 to be within a preset range compared to the target center M of one or more target assemblies 2 that were previously targeted to generate the target beam, and within the preset range, the target center M of the target assembly 2 is at a target position, and the target position makes the target center M at the same position corresponding to other structures in the beam system, so that multiple target assemblies 2 can be positioned at the target position, so that the position of the target assembly 2 after the target material 215 is exhausted and the target is replaced and the target is re-loaded is at the same position corresponding to other structures in the beam system. The positioning device 4 can move or rotate relative to the support device 6, so as to support the target assembly 2, and then make the target center M of the target assembly 2 at the target position.

[0085] During the initial installation and commissioning of the target assembly 2, the target assembly 2, the beam shaper 5, at least one of the charged particle beam generating device 1, etc. can be adjusted so that the target center M, the beam shaper 5, and the reference center of the charged particle beam are in a relatively suitable state. It can be understood that the reference center of the charged particle beam can be a virtual positioning center set for simplifying or analyzing the charged particle beam, rather than the center point of the charged particle beam in the actual application scenario. Considering that the charged particle beam is in a scanning target shooting state in the actual application scenario, the actual center of the charged particle beam during the operation may be offset from the reference center of the charged particle beam.

[0086] The positioning device 4 is arranged on the support device 6, and the positioning device 4 can move relative to the support device 6, so as to be used to position the target assembly 2 to the target position, wherein, at the target position, the target center M is located within a preset range based on the support device 6. It can be understood that the support device 6 is rigidly arranged at a fixed position. The target position (end position) after the positioning operation of the positioning device 4 on the target assembly 2 is based on the support device 6 as a reference. In some embodiments, the preset range can be understood as when the positioning device 4 places the target assembly 2 at the target position, assuming that the support device 6 is taken with the same positioning reference, the vector formed between the target assembly 2 and the positioning reference is within the range allowed by the operation, that is, the distance value and direction of the vector are both within the allowed range. In some embodiments, for example, the target assembly 2 is set at the target position, and the target center M of the target assembly 2 or other positioning references such as positioning points, positioning lines or positioning surfaces in the target assembly 2 may be placed at the target position. Thus, the target assembly 2 is set at the target position, and the positioning reference of the support device 6 is a preset fixed point, a preset fixed line or a preset fixed surface. Assuming that the same positioning reference as the support device 6 is taken, the target assembly 2, that is, the target center M of the target assembly 2 or other positioning references such as positioning points, positioning lines or positioning surfaces in the target assembly 2, and the vector formed between the positioning reference is within the range allowed by the operation, that is, the distance value and direction of the vector are both within the allowed range. The above-mentioned range allowed by the operation is related to the radioactive components of the target assembly 2, and may also be related to the characteristics of the beam shaper 5 and the charged particle beam, and the present invention is not limited to this.

[0087] In some embodiments, the preset range can be understood as when the positioning device 4 places the target assembly 2 at the target position, assuming that a fixed point, a line at a fixed position, or a surface at a fixed position on the support device 6 is taken as a reference, the vector formed between the target assembly 2 and the reference is within the range allowed by the operation, that is, the distance value and direction of the vector are both within the allowed range. In some embodiments, for example, the target assembly 2 is set at the target position, and the target center M of the target assembly 2 or other positioning references such as positioning points, positioning lines, or positioning surfaces in the target assembly 2 are at the target position. Thus, the target assembly 2 is set at the target position, and the reference provided by the support device 6 is a fixed point, a line at a fixed position, or a surface at a fixed position. Assuming that the same reference as the fixed point, line at a fixed position, or surface at a fixed position provided by the support device 6 is taken, the target assembly 2, that is, the target center M of the target assembly 2 or other positioning references such as positioning points, positioning lines, or positioning surfaces in the target assembly 2 and the positioning reference are formed within the range allowed by the operation, that is, the distance value and direction of the vector are both within the allowed range. The range of the interval allowed for the above operation is related to the radioactive components of the target assembly 2, and may also be related to the characteristics of the beam shaper 5 and the charged particle beam, which is not limited in the present invention.

[0088] For the convenience of calculation, any fixed point, fixed position line, or fixed position surface on the support device 6 that is convenient for calculation or positioning can be taken as the reference provided by the support device 6. With the fixed point, fixed position line, or fixed position surface as a reference, the target position of the target center M is within a calibrated range, which is the preset range. Correspondingly, after each reinstallation, the target center M of the target assembly 2 positioned by the positioning device 4 will be located at the target position, at which the target center M is located within the range with the fixed point, fixed position line, or fixed position surface provided by the support device 6 as a reference. Specifically, if at the target position, the target center M is located within the range with the above-mentioned fixed point as a reference, that is, the preset range, the preset range may be related to the position of the fixed point, that is, the height after the positioning device 4 completes positioning of the target assembly 2, and the symmetry plane of the surface contact point of the target assembly 2 when the positioning device 4 completes positioning of the target assembly 2 can be determined through the fixed point. On the symmetry plane, when the target assembly 2 is placed at the height position after positioning is completed, a projection point is determined at the projection position of the target center M on the symmetry plane. The preset range is an area based on the projection point, for example, the preset range is a circular area with a diameter within a preset value based on the projection point. The preset value can be determined according to the characteristics of the radioactive components of the target assembly 2. For example, the preset value is any value between 0.01 cm and 1.5 cm. The present invention is not limited to this. Specifically, the preset value can be 1 mm, 4.5 mm or 8 mm. Within the preset range, after the target assembly 2 is positioned, it can be ensured that the target assembly 2 is in a fixed position relative to the support device 6 after each target loading, and it can be ensured that the target assembly 2 is in a matching position relative to the charged particle beam and the overall structure of the beam shaper 5. At the matching position, the neutron beam generated after each target replacement and re-loading remains stable.

[0089] If at the target position, the target center M is located within the range with reference to the above-mentioned fixed position line, that is, the preset range, the preset range may be related to the position of the fixed position line, that is, the height after the positioning device 4 completes positioning of the target assembly 2, and the symmetry plane with different contact points on the target assembly 2 when the positioning device 4 completes positioning of the target assembly 2 can be determined through the fixed position line. On the symmetry plane, when the target assembly 2 is placed at the height position after positioning is completed, a projection point is determined at the projection position of the target center M on the symmetry plane. The preset range is an area based on the projection point, for example, the preset range is a circular area with a diameter within a preset value based on the projection point. The preset value can be determined according to the characteristics of the radioactive components of the target assembly 2. For example, the preset value is any value between 0.01 cm and 1.5 cm. The present invention is not limited to this. Specifically, the preset value can be 1 mm, 4.5 mm or 8 mm. Within the preset range, after the target assembly 2 is positioned, it can be ensured that the target assembly 2 is in a fixed position relative to the support device 6 after each target loading, and it can be ensured that the target assembly 2 is in a matching position relative to the charged particle beam and the overall structure of the beam shaper 5. At the matching position, the neutron beam generated after each target replacement and re-loading remains stable.

[0090] If at the target position, the target center M is located within the range with reference to the above-mentioned fixed position surface, that is, the preset range, the preset range may be related to the position of the fixed position surface, that is, the height after the positioning device 4 completes positioning of the target assembly 2, and the symmetry surface with different contact points on the target assembly 2 when the positioning device 4 completes positioning of the target assembly 2 can be determined through the fixed position surface. On the symmetry surface, when the target assembly 2 is placed at the height position after positioning is completed, a projection point is determined at the projection position of the target center M on the symmetry surface. The preset range is an area based on the projection point, for example, the preset range is a circular area with a diameter within a preset value based on the projection point. The preset value can be determined according to the characteristics of the radioactive components of the target assembly 2. For example, the preset value is any value between 0.01 cm and 1.5 cm. The present invention is not limited to this. Specifically, the preset value can be 1 mm, 4.5 mm or 8 mm. Within the preset range, after the target assembly 2 is positioned, it can be ensured that the target assembly 2 is in a fixed position relative to the support device 6 after each target loading, and it can be ensured that the target assembly 2 is in a matching position relative to the charged particle beam and the overall structure of the beam shaper 5. At the matching position, the neutron beam generated after each target replacement and re-loading remains stable.

[0091] In some embodiments, the height of the target assembly 2 after the positioning device 4 completes positioning can be determined in the following manner. Specifically, in some embodiments, the support device 6 is rigidly arranged on a reference plane, and the positioning device 4 is arranged on the support device 6. When the positioning device 4 is in a state where the target assembly 2 is positioned, the positioning device 4 has a target lifting height based on the reference plane. After the target assembly 2 is positioned, the target lifting height is the position to which the target center M should be lifted in theory. In the process from the start of positioning to the completion of positioning, the part of the positioning device 4 that supports the movement of the target assembly 2 has an elongated displacement from the positioning start position to the positioning completion position. The target lifting height can be obtained by combining the shape and size value of the matching point of the target assembly 2 and the positioning device 4 and summing the elongated displacement. Specifically, the target assembly 2 and the positioning device 4 match in the displacement direction from the positioning start position to the positioning completion position. The projection distance of the line connecting the matching point and the target center M on the axis of the target center M and the elongated displacement are the sum of the projected distance and the elongated displacement. The target lifting height is the height after the positioning device 4 completes positioning the target assembly 2.

[0092] In some embodiments, the symmetric planes of the positioning device 4 with different contact points on the target assembly 2 when the positioning device 4 completes positioning of the target assembly 2 can be determined in the following manner. Specifically, in some embodiments, the positioning device 4 is supported by the support assembly 6, and the positioning device 4 positions the target assembly 2 to the target position based on the fixation of the support assembly 6. The positioning device 4 positions the target assembly 2 by having a common contact position with the target assembly 24. At the common contact position, the positioning device 4 applies a force to the target assembly 2, and then positions the target assembly 24 to the target position through the force. At the contact position, the positioning device 4 supports the target assembly 2 by interfering with the target assembly 2. The positioning device 4 can support the target assembly 2 by surface contact, line contact or point contact with the target assembly 2. Accordingly, the part located on the target assembly 2 and in contact with the target assembly 2 by the positioning device 4 is defined as a contact surface or a contact line or a contact point. Accordingly, in some embodiments, the contact surfaces or contact lines or contact points are symmetrical based on a symmetry plane or are located on the symmetry plane, thereby determining the symmetry plane with different contact points on the target assembly 2 when the positioning device 4 completes positioning the target assembly 2.

[0093] In some embodiments, if at the target position, the target center M is located in a range with reference to the above-mentioned fixed point, that is, a preset range, the preset range may be related to the position of the fixed point. For example, the fixed point and the support device 6 may define a vertical plane roughly perpendicular to the horizontal plane. The vertical plane and the target or the preset range is a circular area with a diameter within a fixed numerical range based on the fixed point.

[0094] Since the support device 6 and other structures of the neutron capture therapy system are rigidly arranged, they must be on the same reference plane as the rigidly arranged structures such as the beam shaping body 5. The support device 6 is used as a reference to determine the lifting position after the support device 6 positions the target assembly 2. Based on the positioning of the target assembly 2 at the lifting position, the central axis of the target body 21 of the target assembly 2 and the beam shaping body 5 are located at a matching position.

[0095] In some embodiments, in order to ensure that the target center M of the target assembly 2 after each installation is always at the target position, the distance between the target center M and the support device 6 can be always within a preset range. The preset range is based on the support device 6, so that the target assembly 2 can be at the same position as the previous target assembly 2 after each reinstallation under the action of the positioning device 4, thereby making the neutron beam of the neutron capture therapy system more stable.

[0096] In particular, after the positioning device 4 positions the target assembly 2, the target assembly 2 can be supported by the positioning device 4 and the driving frame 31 of the conveying device 3. Even if the two supports do not coincide with the ideal axis, and the ideal axis and the actual axis only intersect at the positioning device 4, as long as the deviation between the target assembly 2 and the reference center of the charged particle beam can be ensured to be within a certain range, that is, the target center M is within the preset range from the support device 6, so as to ensure that the charged particle beam has the same target position each time, the neutron beam generated each time is in a stable state.

[0097] Considering that the positioning device 4 will exert a certain force on the target assembly 2 during positioning, generally speaking, the positioning device 4 provides a force for positioning and supporting the target body 21 having relatively stable rigidity. Of course, in other optional embodiments, the positioning device 4 can also provide a force for positioning and supporting the target accessories 23 such as the cooling pipe 231 under the condition of meeting the design requirements.

[0098] Combination Figure 4 and Figure 6 As shown, in this embodiment, the positioning device 4 may include a driving unit 41 and two clamping mechanisms symmetrically arranged along the first central axis X. Under the action of the driving unit 41, the two clamping mechanisms can approach the target assembly 2 along the direction of the first central axis X, and then clamp the target body 21 from both sides of the target body 21 in a direction close to the target body 21.

[0099] Preferably, it is considered that a gap Z may be formed between the outer side wall of the target body 21 and the target attachment 23 . The two clamping mechanisms can extend into the gap Z and clamp the two sides of the target body 21 .

[0100] The positioning device 4 includes at least one moving unit 42 and at least one bearing unit 43. The at least one moving unit 42 and the at least one bearing unit 43 form a clamping mechanism. Each moving unit 42 has a first pivot center 423, and the moving unit 42 is configured to pivot around the first pivot center 423. Under the action of the driving unit 41, the first pivot center 423 is configured to be able to move in a direction close to the center of the target material 215 to away from the center of the target body 21. The bearing unit 43 is arranged at one end of the corresponding moving unit 42. Under the action of the driving unit 41 and the moving unit 42, the bearing unit 43 can move from a position away from the surface of the target assembly 2 to a position in contact with the surface of the target assembly 2, thereby providing support to the surface of the target assembly 2. In order to limit the movement of the first pivot center 423, the positioning device 4 also includes a first guide portion, which is configured to extend in a direction close to the center of the target assembly 2 to away from the center of the target assembly 2, and the first pivot center 423 is configured to move along the first guide portion. The first guide portion may include a first guide slot 425 , and the first pivot center 423 has a first pin extending into the first guide slot 425 and moving under the limitation of the first guide slot 425 .

[0101] The moving unit 42 also has a second pivot center 424, which is located between the first pivot center 423 and the carrying unit 43 along a direction away from the center of the target assembly 2 to a direction close to the center of the target assembly 2. The moving unit 42 is configured to pivot around the second pivot center 424, and the second pivot center 424 is configured to move along a direction away from the center of the target assembly 2 to a direction close to the center of the target assembly 2 to transport the carrying unit 43 to a surface close to the target assembly 2.

[0102] In order to limit the movement of the second pivot center 424, the positioning device 4 further includes a second guide portion, which is arranged to extend in a direction away from the center of the target assembly 2 to the center close to the target assembly 2, and the second pivot center 424 is arranged to move along the second guide portion. The second guide portion is arranged on a side of the first guide portion close to the target assembly 2, and the second guide portion may include a second guide groove 426, and the second pivot center 424 has a second pin extending into the second guide groove 426 and moving under the limitation of the second guide groove 426.

[0103] Preferably, the second guide groove 426 includes a groove body and a slope section 4261 disposed at one end of the groove body away from the driving unit 41, and the slope section 4261 extends from the groove body from a direction away from the target assembly 2 to a direction close to the target assembly 2 toward the first central axis X. In other words, the distance between one end (the groove body) of the slope section 4261 and the first central axis X is greater than the distance between the other end of the slope section 4261 and the first central axis X. Thus, the carrying unit 43 can move toward the direction close to the first central axis X under the guidance of the second pivot center 424 and the second guide groove 426.

[0104] Specifically, each motion unit 42 includes a first connecting rod 421. A first pivot center 423 is disposed on the first connecting rod 421. A second pivot center 424 is disposed at one end of the first connecting rod 421 close to the bearing unit 43. The bearing unit 43 is disposed at one end of the first connecting rod 421 away from the driving unit 41.

[0105] Combination Figure 4 and Figure 6 As shown, in this embodiment, the bearing unit 43 includes a first bearing member 431 and a second bearing member 432. One end of the first bearing member 431 and one end of the second bearing member 432 are both fixed to an end of the first connecting rod 421 away from the driving unit 41. The other end of the first bearing member 431 and the other end of the second bearing member 432 are respectively provided with a rolling portion 433, and the rolling portion 433 is configured to be adapted to roll on the surface of the target assembly 2 when supporting the target assembly 2.

[0106] In one embodiment of the present invention, the number of the carrying units 43 is at least two, wherein at least one of the carrying units 43 is configured to support the target assembly 2 along the first direction T1, and at least another of the carrying units 43 is configured to support the target assembly 2 along the second direction T2, and the angle W between the first direction T1 and the second direction T2 is greater than or equal to 0 degrees and less than or equal to 180 degrees. The positioning device 4 is provided with at least two carrying units 43, each of which is connected to a moving unit 42, so that under the drive of the moving unit 42, at least one of the carrying units 43 supports the target assembly 2 along the first direction T1, and at least another of the carrying units 43 supports the target assembly 2 along the second direction T2. ​​Specifically, as Figure 7As shown, at least one of the bearing units 43 supports the target assembly 2 along a first direction T1, the first direction T1 is along the T1 direction, the supporting force provided by the at least one bearing unit 43 to the target assembly 2 is the resultant force of the supporting force of the first bearing member 431 on the target assembly 2 and the supporting force of the second bearing member 432 on the target assembly 2, and the direction of the resultant force is along the T1 direction, at least another bearing unit 43 is configured to support the target assembly 2 along a second direction T2, the second direction T2 is along the T2 direction, the supporting force provided by the at least another bearing unit 43 to the target assembly 2 is the resultant force of the supporting force of the first bearing member 431 on the target assembly 2 and the supporting force of the second bearing member 432 on the target assembly 2, and the direction of the resultant force is along the T2 direction, at this time, the angle W between the first direction T1 and the second direction T2 is 180°, and at least two of the bearing units 43 are respectively clamped at the intersection point or intersection line of the same diameter and the contour of the cylindrical part on the surface of the target body 21, preferably, the direction of the diameter of the cylindrical part on the surface of the target body 21 is along the Y direction.

[0107] In other embodiments, at least one bearing unit 43 supports the target assembly 2 along the first direction T1, and the angle W between the first direction T1 and the second direction T2 can be any one of 0°, 30°, 60°, 90°, 120° or 150°, or other angle values ​​in the range of 0° to 180° except the above angle values, so as to facilitate the adaptation of the assembly structure of the target body 21 and the target assembly 2, so that the moving unit 42 and the bearing unit 43 of the positioning device 4 can conveniently approach the target assembly 2 from the direction away from the target assembly 2 after the target assembly 2 moves to the pre-positioning position and fix the target assembly 2 to the target position. This arrangement increases the adaptability of the positioning device 4 to different shape and position combinations between the target body 21 and the target accessory 23.

[0108] Preferably, the first bearing member 431 and the second bearing member 432 can be fixed to the moving unit 42 by being fixed at a certain position. By being fixed at the positioning point, the first bearing member 431 and the second bearing member 432 are symmetrically arranged along the second central axis YY, and the second central axis YY can be a vertical line from the positioning point to the first central axis X. When the positioning device 4 is in a clamping state after the target assembly 2 is clamped, the first bearing member 431 and the second bearing member 432 can make the target center M of the target assembly 2 coincide with the intersection of the first central axis X and the second central axis YY. That is to say, after the positioning device 4 is in action, for the same target assembly 2, the position of the target center M clamped each time is consistent.

[0109] Under the guidance of the first pivot center 423 and the second pivot center 424 of each moving unit 42, the two bearing units 43 can clamp the target body 21 from both sides of the first central axis X, and the first bearing member 431 and the second bearing member 432 can clamp the target body 21 from both sides of the second central axis YY. In the process of moving the target assembly 2 to the target position, since the rolling wheel cooperates with the surface cylindrical contour of the target body 21, after the rolling part 433 and the surface cylindrical contour of the target body 21 are adaptively matched, and in the final state at the target position, the target center M of the target assembly 2 not only matches the reference center of the charged particle beam and the beam shaping body 5, but also the target center M of the target assembly 2 is always in the same position compared with the previous target assembly 2 (for example, the target assembly 2 before replacement). In particular, the bearing unit 43 continues to clamp and fix the target assembly 2 before the target assembly 2 is replaced to ensure that the target assembly 2 is maintained at the target position positioned by the bearing unit 43. In other words, the bearing unit 43 can make the target center M of the target assembly 2 always in the same position, and always in the same position corresponding to the reference center of the charged particle beam and the beam shaping body 5, so as to ensure that the target assembly 2 is in an adapted position relative to the charged particle beam and the beam shaping body 5 after multiple target changes, so that the neutron beam can remain stable after multiple target changes and re-targeting. When the target assembly 2 needs to be replaced, the driving unit 41 can drive the moving unit 42 to be retracted from the target assembly 2 in the direction away from the target assembly 2, so that during the disassembly process, the positioning device 4 will not affect the target assembly 2. After the new target assembly 2 is transported to the preset position by the conveying device 3, the positioning device 4 can be operated under the action of the driving unit 41 until the bearing unit 43 and the target assembly 2 are clamped. In this way, it is also possible to avoid interference between the target assembly 2 and the positioning device 4 during the installation process of the beam shaping body 5.

[0110] In this embodiment, the driving unit 41 has only one output end 411. Each clamping unit further includes a second connecting rod 422, one end of which is connected to the first connecting rod 421 via a first pivot center 423. The other end of the second connecting rod 422 is pivotally connected to the output end 411, thereby ensuring the reliability of power transmission of the positioning device 4.

[0111] Combination Figure 5 and Figure 6As shown, in this embodiment, the support column 62 has a side facing the beam outlet. The driving unit 41 is arranged on the side of the supporting column 62 through a mounting bracket 4. Among them, the first guide portion and the second guide portion are formed on the mounting bracket 4. A guiding mechanism 45 is also arranged between the driving unit 41 and the mounting bracket 4. The guiding mechanism 45 may include a limiting plate 451, one end of which is connected to the driving unit 41, and the other end of which is connected to the motion unit 42 (for example, the second connecting rod 422) by pivoting or other connection methods. The limiting plate 451 is provided with a limiting groove 452 extending in a direction away from the center of the target assembly 2 to the center close to the target assembly 2. The guiding mechanism 45 also includes a positioning pin 453 fixedly arranged on the mounting bracket 4 and inserted into the limiting groove 452. In another optional embodiment, the limiting groove 452 may also be arranged on the mounting bracket 4, and correspondingly, the positioning pin 453 may also be fixedly arranged on the limiting plate 451.

[0112] The positioning device 4 in this embodiment can clamp the target body 21 after moving a certain distance along the first central axis X, avoiding direct clamping from both sides of the target body 21, and avoiding the problem of possible interference with the target accessories 23 on both sides of the target assembly 2 through a relatively simple structure. In addition, the positioning device 4 has a simple structure and a low failure rate, and can be remotely controlled by the driving unit 41, which can reduce unnecessary radiation of the operator.

[0113] In other optional embodiments, the position of the support column 62 can also be set as needed. The positioning device 4 can also be adaptively set according to the position of the support column 62. For example, the positioning device 4 clamps and fixes from other directions according to actual settings.

[0114] For example, one end of the support column 62 may be fixedly connected to the beam shaping body 5 , and the other end of the support column 62 directly supports the lower part of the target assembly 2 .

[0115] For another example, the support column 62 can be disposed above the target assembly 2. The upper end of the support column 62 is fixedly connected to the wall or the top wall of the beam shaping body 5, and the lower end of the support column 62 supports the target assembly 2. The positioning device 4 can move from top to bottom to approach the target assembly 2 and then position the target assembly 2.

[0116] For another example, the support device 6 can be understood as a mechanism including a rail 61 or the like that can provide rigid support to the target assembly 2, or can provide rigid support to the target assembly 2 when the target assembly 2 is at a predetermined position or a target position. The positioning device 4 can also be arranged on other components of the support device 6 such as the rail 61.

[0117] Reference Figure 8As shown, in the second embodiment of the present invention, the positioning device 4 includes at least two carrying units 43. Figure 8 The bearing unit 43 on the left side supports the target assembly 2 along the first direction T1. Fig. 9 The bearing unit 43 on the left side supports the target assembly 2 along the second direction T2. ​​In this embodiment, the angle WW formed between the first direction T1 and the second direction T2 can be 90°. As long as the force conditions and clamping accuracy are met, the angle WW formed between the first direction T1 and the second direction T2 can be between 0-180°.

[0118] In the third embodiment of the present invention, referring to Fig. 9 As shown, the positioning device 4 includes a driving unit 41 and a moving unit 42 arranged on the supporting device 6. The first end of the moving unit 42 is connected to the driving unit 41, so that it can reciprocate in the direction of approaching or moving away from the target assembly 2 under the action of the driving unit 41. The second end of the moving unit 42 opposite to the first end can contact the target assembly 2, thereby providing support to the target assembly 2. The driving unit 41 may include but is not limited to a cylinder, an oil cylinder, an electronic or pneumatic connecting rod, a robot and its structure, a mechanical arm, etc. The second end of the moving unit 42 is provided with a bearing unit 43 for supporting the target assembly 2. The bearing unit 43 has a profiling portion that fits with the fitting surface of the target body 21. During positioning, the profiling portion of the bearing unit 43 fits with the fitting surface of the target body 21. Generally speaking, the fitting surface of the target body 21 is a circular arc surface. Adaptively, the profiling portion of the bearing unit 43 can also be circular arc-shaped. Of course, in other optional embodiments, the fitting surface of the target body 21 can also be a plane, a wavy surface, a V-shaped surface, etc. as required. At this time, the contoured portion of the carrier unit 43 can be adaptively contoured according to the contact surface of the target body 21 .

[0119] In the fourth embodiment of the present invention, referring to Fig.10 As shown, the target assembly 2 includes a target body 21 and a target attachment 23 arranged on the periphery of the target body 21. The target attachment 23 includes a plurality of cooling pipes 231, and the plurality of cooling pipes 231 are arranged at intervals. A gap Z is formed between two adjacent cooling pipes 231. The positioning device 4 includes a driving unit 41 and a moving unit 42 arranged on the supporting device 6, and the driving unit 41 can make the moving unit 42 extend into the gap Z, thereby providing support for the target body 21. For example, the driving unit 41 can include a first driving device that moves in a direction of approaching or moving away and a second driving device arranged on the first driving device, and the second driving device can make the moving unit 42 penetrate into or out of the gap Z between the cooling pipes 231 by moving or rotating.

[0120] In the fifth embodiment of the present invention, referring to Fig.11As shown, the target assembly 2 includes a target body 21 and a target attachment 23 disposed on the periphery of the target body 21. The target attachment 23 forms a through gap Z. The positioning device 4 includes a driving unit 41 and a moving unit 42 disposed on the supporting device 6. The driving unit 41 can make the moving unit 42 extend into the gap Z, thereby providing support to the target body 21.

[0121] In the sixth embodiment of the present invention, referring to Fig.12 As shown, the target assembly 2 includes a target body 21 and a target attachment 23 disposed on the periphery of the target body 21. The number of the target attachments 23 is multiple, and part of the positioning device 4 can extend into a gap Z formed between at least two of the target attachments 23, so as to position the target body 21. A gap Z may also be formed between the outer wall of the target body 21 and the target attachment 23. Part of the positioning device 4 can extend into the gap Z formed between the outer wall of the target body 21 and the target attachment 23.

[0122] In the seventh embodiment of the present invention, referring to Fig.13 As shown, the target accessory 23 includes a limiting portion 233 disposed on the periphery of the target body 21, and a cooling pipe 231 passing through the limiting portion 233; the positioning device 4 is used to support the limiting portion 233 to position the target assembly 2. Of course, in other optional embodiments, the positioning device 4 can also position other target accessories such as the cooling pipe 231 in the target assembly 2 under the condition of meeting the requirements of force and positioning.

[0123] In one embodiment, the method for operating the neutron capture therapy system comprises the following steps:

[0124] Removing the target assembly 2 that needs to be replaced from the target position;

[0125] transporting a new target assembly 2 to a preset position;

[0126] The new target assembly 2 at the preset position is positioned so that the target assembly 2 is at the target position.

[0127] Before the step of “removing the target assembly 2 that needs to be replaced from the target position”, the positioning device 4 may be retracted first to avoid interference.

[0128] In the step of “transporting a new target assembly 2 to a preset position”, the preset position of the target assembly 2 corresponds to the end position of the movement of the transport device 3 that transports the target assembly 2 .

[0129] It should be understood that the above description is for illustration and not for limitation. Many embodiments and many applications beyond the examples provided will be apparent to those skilled in the art upon reading the above description. Therefore, the scope of the present teachings should not be determined with reference to the above description, but rather with reference to the foregoing claims and the full scope of equivalents to which such claims are entitled. For the purpose of comprehensiveness, all articles and references, including disclosures of patent applications and publications, are incorporated herein by reference. The omission of any aspect of the subject matter disclosed herein in the foregoing claims is not intended to be a waiver of such subject matter, nor should it be considered that the applicant has not considered such subject matter to be part of the disclosed application subject matter.

Claims

1. A target alignment device, characterized in that: include: a target assembly having a target center; A supporting device, used for supporting the target assembly; A positioning device is arranged on the supporting device, and the positioning device can move relative to the supporting device, so as to position the target assembly to a target position, wherein at the target position, the target center is located within a preset range based on the supporting device.

2. The target alignment device according to claim 1, characterized in that: The target assembly includes a target body and a target accessory disposed on the periphery of the target body. The positioning device is used to support the target body and / or the target accessory to position the target assembly to the target position.

3. The target alignment device according to claim 2, characterized in that: The positioning device is used to support the target body, and the positioning device is in conflict with the target body.

4. The target alignment device according to claim 2, characterized in that: The positioning device extends from between the target attachment and the outer periphery of the target body and contacts the target body to support the surface of the target body; and / or, The target attachment is configured to have a spacing space, and the positioning device extends from the spacing space into and abuts against the target body to position the target body.

5. The target alignment device according to claim 2, characterized in that: The target accessory comprises a limiting portion arranged on the periphery of the target body, and a cooling pipe passing through the limiting portion; The positioning device is supported on the limiting portion to position the target assembly.

6. The target alignment device according to claim 1, characterized in that: The positioning device includes a moving unit and a bearing unit, the moving unit drives the bearing unit so that the bearing unit supports the target assembly, the bearing unit has a contour portion, the target assembly has a fitting surface, the contour portion can fit with the fitting surface so that the bearing unit supports the target assembly.

7. The target alignment device according to claim 1, characterized in that: The positioning device includes a moving unit and a carrying unit, wherein the moving unit drives the carrying unit so that the carrying unit supports the target assembly, and the number of the carrying units is at least two, wherein at least one of the carrying units is configured to support the target assembly along a first direction, and at least another of the carrying units is configured to support the target assembly along a second direction, and an angle between the first direction and the second direction is greater than or equal to 0 degrees and less than or equal to 180 degrees.

8. The target alignment device according to claim 1, characterized in that: The positioning device comprises: at least one motion unit, the motion unit having a first pivot center, the motion unit being configured to pivot about the first pivot center; At least one bearing unit, the bearing mechanism is arranged at one end of the motion unit; The first pivot center is configured to be movable in a direction close to the center of the target material to away from the center of the target body, so that the supporting unit is driven by the moving unit to move from a position away from the surface of the target assembly to a position in contact with the surface of the target assembly to support the surface of the target assembly.

9. A neutron capture therapy system, characterized in that: include: A charged particle beam generating device, used for outputting a charged particle beam; a target assembly for reacting with the charged particle beam to produce a neutron beam; A conveying device, used to drive the target assembly to move to a predetermined position; A positioning device, wherein the positioning device can interfere with the target assembly, wherein the positioning device is used to place the target assembly at a target position after the conveying device places the target assembly at a predetermined position.

10. The neutron capture therapy system according to claim 9, characterized in that: The target assembly comprises a target body and a target accessory arranged on the periphery of the target body. The positioning device is used to support the target body, and the positioning device is in conflict with the target body.

11. The neutron capture therapy system according to claim 10, characterized in that: Also includes: A beam shaper, used for shaping the neutron beam; The beam shaping body can be used to accommodate at least part of the target assembly, and the target assembly also includes a target material arranged in one end of the target body, and the end of the target body provided with the target material is accommodated in the beam shaping body, and the positioning device is used to position the end of the target body away from the target material.

12. The neutron capture therapy system according to claim 9, characterized in that: The target assembly further comprises a beam shaping body. After the target assembly moves to a predetermined position, the end of the target assembly generating the neutron beam abuts against the beam shaping body.

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