Tablet press sealing system

Abstract

The invention discloses a tablet press closed system which comprises a closed tablet press, the closed tablet press is communicated with a closed screening machine, the closed screening machine is connected with a cleaning auxiliary trolley through a pipeline, a main machine cleaning system is arranged in the closed tablet press, and a main machine water outlet, an auxiliary machine water outlet and a screening dust suction inlet are formed in the bottom of the closed tablet press. The main machine drainage port is connected with a main machine cleaning system, the auxiliary machine drainage port and the screen piece dust collection port are respectively connected with a closed screen piece machine and are respectively communicated with the main drainage port through pipelines, the main drainage port is connected with a waste liquid treatment pond through a pipeline, and the screen piece dust collection port is communicated with the main dust collection port through a medicine powder dust collection pipe. And the total dust accumulation port is connected with a primary and medium efficient dust collector through a pipeline. In the whole system, a plurality of sealing structures and dust and wastewater absorption treatment devices are arranged, so that collinear production of medicines is ensured to meet related requirements of laws and regulations, and residual values meet standard requirements after dust and wastewater treatment. And the safety requirements of operators and the environment are improved.

Description

Technical Field

[0001] The invention belongs to the technical field of pharmaceutical equipment, and in particular relates to a tablet pressing machine closure system. Background Art

[0002] In accordance with the requirements clearly stipulated in laws, regulations, rules and national standards, when a drug has risks such as cytotoxicity, narrow therapeutic window, genotoxicity, carcinogenicity, as well as PDE / ADE values, occupational exposure limits, toxicological concern thresholds, etc., the production equipment needs dedicated facilities or equipment for production.

[0003] At present, there is a lack of such process equipment on the market. Therefore, during production, workers are required to wear protective clothing and work in a small, closed space to minimize the spread of toxic drugs and avoid the spread of toxic drugs and endanger the health of others. Summary of the invention

[0004] The problem to be solved by the present invention is to provide a tablet pressing non-sealing system, which is particularly simple in structure and easy to operate, complies with relevant requirements of laws and regulations, meets usage needs, and ensures that the residual level meets a predetermined acceptable standard through a sealing structure.

[0005] In order to solve the above technical problems, the technical solution adopted by the present invention is: a closed system for tablet pressing, including a closed tablet press, the top of the closed tablet press is connected to an IBC barrel through an ab valve, the IBC barrel is moved up and down by a hoist to complete the loading of raw material powder, the closed tablet press is connected to a closed tablet screen, the closed tablet screen is connected to a continuous bag and a finished product continuous collection bag through a pipeline, the closed tablet screen is connected to a cleaning auxiliary trolley through a pipeline, the cleaning auxiliary trolley ensures the sealing of the continuous bag scheme during cleaning, and the closed tablet press is connected to a closed bag screen through a pipeline. A main machine cleaning system is provided in the tablet press, and a main machine drain port, an auxiliary machine drain port and a screen dust suction port are provided at the bottom of the closed tablet press, the main machine drain port is connected to the main machine cleaning system, the auxiliary machine drain port and the screen dust suction port are respectively connected to the closed screen machine, the main machine drain port and the auxiliary machine drain port are respectively connected to the main drain port through pipelines, the main drain port is connected to the waste liquid treatment tank through a pipeline, the screen dust suction port is connected to the total dust accumulation port through a powder dust collecting pipe, and the total dust accumulation port is connected to a junior high school high-efficiency vacuum cleaner through a pipeline.

[0006] Furthermore, the closed tablet press includes a box body, an isolation cover is provided above the box body, the isolation cover is a square columnar body, an isolation door is provided on one side of the isolation cover, the isolation door and the connecting end of the isolation cover are connected by a closed integrated hinge to facilitate the opening and closing of the isolation door, and an air-sealing component is provided at the opening and closing end of the isolation door and the isolation cover, and the air-sealing component isolates toxic dust.

[0007] Furthermore, a closed glove box is provided on one side of the isolation cover, and rubber gloves are installed in the closed glove box to facilitate operators to adjust the equipment in a closed state.

[0008] Furthermore, the enclosed glove box is arranged on the isolation door.

[0009] Furthermore, the isolation doors are in four groups, and the four groups of isolation doors are respectively placed on four sides of the isolation cover.

[0010] Furthermore, a closed discharge box is provided on one side of the isolation cover, and the closed discharge box integrates waste rejection, sampling and finished product channels in a closed state. A continuous transfer cabin is provided on the opposite side of the isolation cover and the closed discharge box, and the continuous transfer cabin supports the transfer of workpieces and materials in a closed state.

[0011] Furthermore, it also includes an auxiliary fan, which is connected to the sealed tablet press. When the main fan suddenly stops working, the auxiliary fan is urgently started to maintain the negative pressure condition of the isolation cover chamber.

[0012] Furthermore, a push push cylinder is provided in the closed tablet press, and the push push cylinder supports emergency intervention work in the event that the main fan is suddenly disconnected.

[0013] Furthermore, a turntable is provided inside the closed tablet press, and the turntable is mounted on a main shaft. A main shaft oil seal is provided on the main shaft, and the main shaft oil seal prevents oil leakage. The closed tablet press is provided with an internal discharge box near the turntable, and the internal discharge box is connected to an external discharge box. The internal discharge box cooperates with the external discharge box and is responsible for the output of finished products. The closed tablet press is provided with a diaphragm valve near the bottom of the internal discharge box, and the diaphragm valve is responsible for drainage inside the isolation cover.

[0014] Furthermore, a sealing cover is provided above the turntable, and a sealing ring and a sealing ring bottom plate are provided at the contact point between the sealing cover and the upper surface of the turntable. A pressure roller support system is also provided above the turntable, and the sealing ring, the sealing bottom plate and the pressure roller support system form a closed cavity to prevent dust and cleaning fluid from entering the transmission mechanism. A powder suction box is provided below the turntable, and the powder suction box sucks away the dust.

[0015] The advantages and positive effects of the present invention are:

[0016] The present invention has a simple structure and is easy to operate. By setting multiple sealing structures and dust and wastewater absorption and treatment devices in the entire system, it ensures that the co-production of drugs complies with the relevant requirements of laws and regulations. After the dust and wastewater are treated, the residual value meets the standard requirements, thereby improving the safety requirements of operators and the environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present invention.

[0018] Figure 2 The figure is a schematic diagram of the bottom structure of a closed tablet press according to an embodiment of the present invention.

[0019] Figure 3 , Figure 4 Schematic diagram of the internal structure of a closed tablet press according to an embodiment of the present invention.

[0020] In the figure:

[0021] 1. Powder dust collection pipe; 2. Main machine drain outlet; 3. Main drain outlet;

[0022] 4. Total dust accumulation port; 5. Duckbill valve; 6. Screen dust suction port;

[0023] 7. Auxiliary machine drain port; 8. Isolation door; 9. Sealed glove box;

[0024] 10. Sealed discharge box; 11. Sealed integrated hinge; 12. Airtight sealing assembly;

[0025] 13. Continuous transfer cabin; 14. Lighting equipment; 15. Push push cylinder;

[0026] 16. Door opening detection device; 17. Isolation cover; 18. Internal discharge box;

[0027] 19. External discharge box; 20. Diaphragm valve; 21. Turntable;

[0028] 22. Spindle oil seal; 23. Powder suction box; 24. Sealing ring;

[0029] 25. Sealing bottom plate; 26. Sealing cover; 27. Pressing wheel supporting system;

[0030] 28. Junior and middle school high-efficiency vacuum cleaner; 29. ​​Cleaning auxiliary trolley; 30. Finished product continuous collection bag;

[0031] 31. Pipeline connected to continuous bag; 32. Closed tablet screening machine; 33. Closed tablet pressing machine;

[0032] 34. Hoist; 35. Main engine cleaning system; 36. AB valve;

[0033] 37. IBC barrel; 38. Auxiliary fan. DETAILED DESCRIPTION

[0034] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0036] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0037] The embodiments of the present invention are further described below in conjunction with the accompanying drawings:

[0038] like Figure 1 , Figure 2As shown, a closed system for tablet pressing includes a closed tablet press 33, the top of which is connected to an IBC barrel 37 through an ab valve 36, and the IBC barrel 37 is moved up and down by a hoist 34 to complete the loading of raw material powder. The closed tablet press 33 is connected to a closed sieving machine 32, and the closed sieving machine 32 is connected to a continuous bag 31 and a finished product continuous collection bag 30 through a pipeline, and the closed sieving machine 32 is connected to a cleaning auxiliary trolley 29 through a pipeline, and the cleaning auxiliary trolley 29 ensures that the continuous bag scheme is sealed during cleaning. A main cleaning system 35 is provided in the closed tablet press 33, and a main drain port 2, an auxiliary drain port 7 and a sieve dust suction port 6 are provided at the bottom of the closed tablet press 33. The main drain port 2 is connected to the main cleaning system 35, and the waste liquid generated by the main cleaning system 35 is collected through the main drain port 3 to the waste liquid treatment tank for treatment. The auxiliary machine drain port 7 and the sieve dust suction port 6 are respectively connected to the closed sieve machine 32, and the main machine drain port 2 and the auxiliary machine drain port 7 are respectively connected to the main drain port 3 through pipelines. The main drain port 3 is connected to the waste liquid treatment tank through a pipeline, and the sieve dust suction port 6 is connected to the total dust storage port 4 through the powder dust collection pipe 1. The waste water and waste gas generated by the sieve dust suction port 6 and the auxiliary machine drain port 7 are collected through the total drain port 3 and the total dust collection port 4, and the duckbill valve 5 adjusts the auxiliary machine dust suction air volume. The total dust storage port 4 is connected to the junior and high-efficiency vacuum cleaner 28 through a pipeline. The powder dust collection pipe 1 is connected to the total dust storage port 4, and is discharged outdoors after being purified by the junior and high-efficiency vacuum cleaner 28.

[0039] The junior high school high-efficiency vacuum cleaner 28 filters the toxic powder from the main machine and auxiliary machine, the cleaning auxiliary trolley 29 completes the sealing problem during the continuous bag cleaning, and the finished product continuous collection bag 30 completes the continuous collection of finished products. The pipeline connection continuous bag 31 disconnects the connection between the equipment after the tableting is completed, the closed tablet screen 32 completes the dust removal and burr removal of the finished tablets, the closed tablet press 33 is to complete the tablet pressing of the closed main machine, the elevator 34 cooperates with the IBC barrel 37 to complete the lifting of the raw material powder through the ab valve 36 into the closed tablet press 33, the main cleaning system 35 is cleaned after the pressing is completed, and the cleaning waste liquid is discharged through the main drain 3, and the auxiliary fan 38 is started urgently when the main fan suddenly stops working to maintain the negative pressure working condition of the isolation cover 17 chamber.

[0040] like Figure 3As shown, the closed tablet press 33 includes a box body, an isolation cover 17 is provided above the box body, the isolation cover 17 is an integral frame supporting all parts, the isolation cover 17 is a square columnar body, an isolation door 8 is provided on one side of the isolation cover 17, the isolation door 8 and the connection end of the isolation cover 17 are connected by a closed integrated hinge 11, which is convenient for the opening and closing of the isolation door 8, and an airtight sealing assembly 12 is provided at the opening and closing end of the isolation door 8 and the isolation cover 17, the isolation door 8 isolates the toxic dust through the airtight sealing assembly 12, the closed integrated hinge 11 supports the isolation door 8 mechanism switch, and the airtight sealing assembly 12 completes the overall closed state of the isolation cover 17 in the working state. Preferably, the closed tablet press 33 is also provided with a door opening detection device 16. A closed glove box 9 is provided on one side of the isolation cover 17, and rubber gloves are installed in the closed glove box 9 to facilitate the operator to adjust the equipment in a closed state. As shown Figure 3 As shown, the closed glove box 9 is arranged on the isolation door 8. The isolation door 8 provided in this embodiment is four groups, and the four groups of isolation doors 8 are respectively placed on the four sides of the isolation cover 17. Preferably, the closed tablet press 33 is provided with a lighting device 14.

[0041] like Figure 4 As shown, a closed discharge box 10 is provided on one side of the isolation cover 17. The closed discharge box 10 integrates waste rejection, sampling and finished product channels in a closed state. A continuous transfer cabin 13 is provided on the opposite side of the isolation cover 17 and the closed discharge box 10. The continuous transfer cabin 13 supports the transfer of workpieces and materials in a closed state. A push push cylinder 15 is provided in the closed tablet press 33. The push push cylinder 15 supports emergency intervention work in the event of a sudden disconnection of the main fan. A turntable 21 is provided in the closed tablet press 33. The turntable 21 is made of a special material and has the characteristics of rust resistance and corrosion resistance. The turntable 21 is installed on the main shaft, and a main shaft oil seal 22 is provided on the main shaft. The main shaft oil seal 22 prevents oil from leaking. An internal discharge box 18 is provided near the turntable 21 of the closed tablet press 33. The internal discharge box 18 is connected to the external discharge box 19. The internal discharge box 18 cooperates with the external discharge box 19 to be responsible for the output of finished products. The closed tablet press 33 is provided with a diaphragm valve 20 near the lower part of the internal discharge box 18, and the diaphragm valve 20 is responsible for draining the inside of the isolation cover 17. A sealing cover 24 is provided above the turntable 21, and a sealing ring 24 and a sealing ring bottom plate 25 are provided at the contact point between the sealing cover 24 and the upper surface of the turntable 21. A pressure roller support system 27 is also provided above the turntable 21. The sealing ring 24, the sealing bottom plate 25 and the pressure roller support system 27 form a closed cavity to prevent dust and cleaning liquid from entering the transmission mechanism. A powder suction box 23 is provided below the turntable 21, and the powder suction box 23 sucks away the dust thrown out.

[0042] The advantages and positive effects of the present invention are:

[0043] The present invention has a simple structure and is easy to operate. By setting multiple sealing structures and dust and wastewater absorption and treatment devices in the entire system, it ensures that the co-production of drugs complies with the relevant requirements of laws and regulations. After the dust and wastewater are treated, the residual value meets the standard requirements, thereby improving the safety requirements of operators and the environment.

[0044] The embodiments of the present invention are described in detail above, but the contents described are only preferred embodiments of the present invention and cannot be considered to limit the scope of implementation of the present invention. All equivalent changes and improvements made within the scope of the present invention should still fall within the scope of the patent coverage of the present invention.

Claims

1. A tableting closed system, characterized in that: The invention comprises a closed tablet press, wherein the top of the closed tablet press is connected to an IBC barrel through an ab valve, the IBC barrel is moved up and down by a hoist to complete the loading of raw material powder, the closed tablet press is communicated with a closed sieving machine, the closed sieving machine is connected to a continuous bag through a pipeline and is communicated with a continuous collection bag of finished products, the closed sieving machine is connected to a cleaning auxiliary trolley through a pipeline, the cleaning auxiliary trolley ensures the sealing of the continuous bag scheme during cleaning, a main cleaning system is arranged in the closed tablet press, a main drain port, an auxiliary drain port and a sieving dust suction port are arranged at the bottom of the closed tablet press, the main drain port is connected to the main cleaning system, the auxiliary drain port and the sieving dust suction port are respectively connected to the closed sieving machine, the main drain port and the auxiliary drain port are respectively communicated with a total drain port through pipelines, the total drain port is connected to a waste liquid treatment tank through a pipeline, the sieving dust suction port is communicated with a total dust accumulation port through a powder dust collecting pipe, and the total dust accumulation port is connected to a junior and high-efficiency dust collector through a pipeline.

2. A tablet pressing closed system according to claim 1, characterized in that: The closed tablet press comprises a box body, an isolation cover is arranged above the box body, the isolation cover is a square columnar body, an isolation door is arranged on one side of the isolation cover, the isolation door and the connection end of the isolation cover are connected by a closed integrated hinge to facilitate the opening and closing of the isolation door, and an air sealing component is arranged at the opening and closing end of the isolation door and the isolation cover, and the air sealing component isolates toxic dust.

3. A tablet pressing closed system according to claim 2, characterized in that: A closed glove box is provided on one side of the isolation cover, and rubber gloves are installed in the closed glove box to facilitate operators to adjust the equipment in a closed state.

4. A tablet pressing closed system according to claim 3, characterized in that: The enclosed glove box is arranged on the isolation door.

5. A tablet pressing closed system according to any one of claims 2 to 4, characterized in that: There are four groups of isolation doors, and the four groups of isolation doors are respectively placed on four sides of the isolation cover.

6. A tablet pressing closed system according to any one of claims 2 to 4, characterized in that: A closed discharge box is provided on one side of the isolation cover, and the closed discharge box integrates waste rejection, sampling and finished product channels in a closed state. A continuous transfer cabin is provided on the opposite side of the isolation cover and the closed discharge box, and the continuous transfer cabin supports the transfer of workpieces and materials in a closed state.

7. A tablet pressing closed system according to any one of claims 2 to 4, characterized in that: It also includes an auxiliary fan, which is connected to the sealed tablet press. When the main fan suddenly stops working, the auxiliary fan is urgently started to maintain the negative pressure condition of the isolation cover chamber.

8. A tablet pressing closed system according to any one of claims 2 to 4, characterized in that: A push push cylinder is provided in the closed tablet press, and the push push cylinder supports emergency intervention work in the event of a sudden disconnection of the main blower.

9. A tablet pressing closed system according to any one of claims 2 to 4, characterized in that: A turntable is provided inside the closed tablet press, and the turntable is mounted on a main shaft. A main shaft oil seal is provided on the main shaft, and the main shaft oil seal prevents oil leakage. An internal discharge box is provided near the turntable of the closed tablet press, and the internal discharge box is connected to an external discharge box. The internal discharge box cooperates with the external discharge box and is responsible for outputting finished products. A diaphragm valve is provided below the internal discharge box of the closed tablet press, and the diaphragm valve is responsible for drainage inside the isolation cover.

10. A tablet pressing closed system according to claim 9, characterized in that: A sealing cover is provided above the turntable, and a sealing ring and a sealing ring bottom plate are provided at the contact point between the sealing cover and the upper surface of the turntable. A pressure roller support system is also provided above the turntable, and the sealing ring, the sealing bottom plate and the pressure roller support system form a closed cavity to prevent dust and cleaning liquid from entering the transmission mechanism. A powder suction box is provided below the turntable, and the powder suction box sucks away the dust.

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