Nanometer mixer

Abstract

The invention provides a nanometer mixing instrument. The nanometer mixing instrument comprises a chip; the injectors comprise the first injector and the second injector, the first injector is used for containing the first liquid, and the second injector is used for containing the second liquid; each injector comprises a push rod which is used for pushing the first liquid and the second liquid into the chip from the corresponding injector; the lead screw assembly is provided with a pushing assembly making contact with the push rod, the pushing assembly is driven by the lead screw assembly to push the push rod to move, the extending direction of the lead screw assembly is parallel to the arrangement direction of the injector, and the side face of the lead screw assembly faces the injector; the connecting plate is arranged between the injector and the lead screw assembly, the lead screw assembly and the chip are both fixed to the connecting plate, a channel allowing the pushing assembly to penetrate through is formed in the connecting plate, and the extending direction of the channel is the same as the moving direction of the push rod. And the liquid pushing stability of the injector is improved.

Description

Technical Field

[0001] The present invention relates to a nano mixer. Background Art

[0002] Microfluidic chip technology is a technology based on the theory of hydrodynamics, which integrates basic operation units such as sample preparation, reaction, separation, and detection in the process of biological, chemical, and medical analysis onto a chip with a micron scale, and automatically completes the entire analysis process. When implementing the preparation process of lipid nanoparticles (LNP), it is necessary to inject the aqueous phase and the oil phase at two inlets of the microfluidic chip respectively to mix them inside the chip.

[0003] Currently, in the prior art, the injection method using a syringe is usually adopted to realize the mixing of the aqueous phase and the oil phase. This quantitative injection method has a simple structure, low cost, and there will be no residual aqueous phase or oil phase liquid in the syringe barrel. However, this solution is usually only suitable for small-scale preparations (the syringe volume is less than 10 mL). If a syringe with a larger capacity (for example, 20 mL to 100 mL) is used, the thrust required to press the syringe push rod also increases with the increase in the injected liquid volume. Due to problems such as insufficient stiffness of the push arm and reliability of the drive module in the traditional injection mixer, high-precision flow control cannot be achieved when injecting a large volume of liquid. Therefore, for slightly larger-scale preparations in the prior art, a continuous delivery method such as a peristaltic pump must be used to inject the aqueous phase and the oil phase liquid into the chip. However, with the pump solution, the liquid often remains in the pump body and causes waste, and there are also problems such as high cost and difficult control of the injection speed. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the defects of the prior art and provide a nano mixer.

[0005] The present invention solves the above technical problem through the following technical solutions:

[0006] A nano mixer, the nano mixer includes:

[0007] A chip;

[0008] Syringes, the syringes include a first syringe and a second syringe. The first syringe is used to hold a first liquid, and the second syringe is used to hold a second liquid; the syringes include push rods, which are used to push the first liquid and the second liquid from their respective syringes into the chip respectively;

[0009] A lead screw assembly, on which a pushing assembly in contact with the push rod is provided. The pushing assembly is driven by the lead screw assembly to push the push rod to move. The extending direction of the lead screw assembly is parallel to the setting direction of the syringe, and the side surface of the lead screw assembly faces the syringe;

[0010] A connecting plate, the lead screw assembly and the chip are both fixed to the connecting plate, the syringe is arranged on the front side of the connecting plate, the lead screw assembly is arranged on the back side of the connecting plate, and the connecting plate is provided with a channel for the pushing arm to pass through, and the extension direction of the channel is the same as the moving direction of the push rod.

[0011] In the present technical solution, by changing the position of the screw assembly and setting the side of the screw assembly toward the syringe, the extension length of the push rod part connecting the screw assembly to the syringe is reduced compared to the screw assembly layout solution in the prior art, thereby shortening the cantilever length of the entire pushing assembly, improving the stability of the push rod of the syringe, and reducing its bending and swinging by shortening the length of the pushing assembly.

[0012] At the same time, the lead screw assembly and the chip are arranged on the connecting plate to provide a reliable mounting point, thereby improving the overall structural rigidity of the nanomixer and effectively solving the problem that when the current pushing assembly pushes the push rod of a large-capacity syringe, the pushing resistance increases and the structural rigidity is insufficient, causing jitter, which in turn leads to uneven sample integration and affects the mixing effect.

[0013] Therefore, such a structural setting scheme can effectively avoid the defect of flow fluctuation and poor mixing effect when the syringe injects a large volume of water phase or oil phase, so that the single mixing scheme injected by syringe can also be used in relatively large-volume mixing processes, effectively solving the current large-volume mixing process in the prior art must use a peristaltic pump for mixing, resulting in the presence of liquid residue in the pump body, high cost, and difficult to control the injection speed.

[0014] Preferably, the screw assembly includes a screw rod and a driving motor connected to the screw rod and driving the screw rod to rotate, and the pushing assembly is arranged on the screw rod, so that the driving motor drives the screw rod to drive the pushing assembly to push the push rod.

[0015] In the technical solution, by adopting this structural form, the driving motor can realize automatic control of the nano mixer, increasing the intelligence and remote control capability of the nano mixer. Moreover, through the driving motor, the speed and position of the push assembly when moving up and down along the lead screw assembly can be accurately controlled to achieve a predetermined translation distance and speed. At the same time, the driving motor can provide a stable driving force, reduce the unstable factors of manual operation, and ensure the stability and consistency of the movement of the push assembly each time, so as to ensure the uniformity and stability of the liquid to be mixed pushed out by the syringe. In addition, the automatically driven nano mixer can improve the efficiency of the experiment.

[0016] Preferably, the pushing assembly includes a slider, a pushing arm and a pushing member, the slider is arranged on the lead screw assembly and is driven by the lead screw assembly, and the pushing member is connected to the slider through the pushing arm and is arranged close to the push rod.

[0017] In the present technical solution, the slider of the pushing assembly is driven by the screw assembly and can move on the screw assembly, and transmit the driving force to the pushing member through the pushing arm connected to the slider, so that the pushing member can push the push rod of the syringe smoothly and consistently.

[0018] Preferably, the pushing member includes a fixed member and a movable member, the fixed member is connected to the pushing arm, the movable member is pivotally connected to the fixed member, the upper surface of the movable member is used to contact the push rod, and a micro switch is arranged in the fixed member, and the contacts of the micro switch abut upward against the lower surface of the movable member.

[0019] By setting the movable part to contact the push rod, the reaction force from the push rod when the movable part contacts the push rod is used to press the contact of the micro switch, and the signal sent by the micro switch is used as the basis for the pushing component to drive the push rod to move upward, the accuracy of the nano mixer can be improved.

[0020] Preferably, the syringe, and / or the lead screw assembly, and / or the chip are detachably connected to the connecting plate respectively by screws.

[0021] In this technical solution, the connecting plate provides a firm connection point, so that the structural stability and reliability between the chip, the screw assembly and the syringe are guaranteed. The connection between the chip, the screw assembly and the syringe and the connecting plate is achieved by screws, which facilitates the disassembly and replacement of parts and improves the maintainability of the equipment.

[0022] Preferably, the nano-mixer further comprises a containing assembly, which is arranged on a side of the connecting plate away from the lead screw assembly, and a containing space is provided on the containing assembly, wherein the containing space has an entrance and exit for the chip to enter and exit.

[0023] In the technical solution, a receiving assembly is provided to receive the chip, thereby achieving the purpose of quickly installing and removing the chip.

[0024] Preferably, the nano-mixer further comprises a flipping structure and a positioning structure, the containing assembly is connected to the connecting plate via the flipping structure, and the containing assembly can be flipped relative to the connecting plate to change the orientation of the inlet and outlet;

[0025] The positioning structure is connected to the connecting plate and abuts against the containing assembly to position the direction of the entrance and exit.

[0026] In this technical solution, by setting the flipping structure, the orientation of the entrance and exit can be changed, facilitating the installation of the chip relative to the accommodating component. At the same time, a positioning structure is set to lock the orientation of the entrance and exit, preventing the chip from detaching from the accommodating component due to the change in the orientation of the entrance and exit when the nano mixer is working properly.

[0027] Preferably, the positioning structure is positioned on the connecting plate by a magnetic attraction method.

[0028] In this technical solution, the positioning structure is positioned on the connecting plate by a magnetic attraction method. Compared with other positioning methods, it has a high connection efficiency and is also easy to release the positioning, facilitating the installation of the chip relative to the accommodating component.

[0029] Preferably, along the moving direction of the push rod of the syringe, the contact surface between the pushing member and the push rod is a planar structure, and the surface area of the planar structure is not less than the contact area between the pushing member and the push rod.

[0030] In this technical solution, by increasing the surface area of the planar structure on the side of the pushing member close to the push rod, the contact area between the pushing member and the push rod can be increased, ensuring the best contact between the push rod and the pushing arm, thereby enhancing the stability of their connection. In this way, the swing and deviation of the push rod during movement can be reduced, maintaining the smoothness and accuracy of the movement. Moreover, the larger surface area can provide a stronger contact force, thereby increasing the torque transmission capacity, and can better transmit the torque of the pushing member to the push rod, providing sufficient force to push the push rod to move. At the same time, the larger cross-sectional size can provide the pushing member with stronger rigidity and load-bearing capacity, reducing the deformation and the risk of deformation generated during movement, and thus can improve the accuracy and stability of the nano mixer.

[0031] Preferably, the material of the pushing component is steel.

[0032] In this technical solution, by using this material for the pushing component, the rigidity of the pushing component and the stability of its pushing the push rod of the syringe can be enhanced, preventing the pushing component from being easily deformed when pushing the push rod, enabling the lead screw component to be in a stable state of pushing the push rod for a long time, and maintaining the normal progress of the experiment.

[0033] The positive and progressive effects of the present invention are as follows: By changing the position of the lead screw component and setting the side surface of the lead screw component facing the syringe, compared with the lead screw component layout scheme in the prior art, the extension length of the part of the pushing component connecting the lead screw component to push the push rod of the syringe is reduced, thereby shortening the cantilever length of the entire pushing component, improving the stability of pushing the push rod of the syringe, and reducing its bending and swinging by shortening the length of the pushing component.

[0034] Meanwhile, the lead screw assembly and the chip are directly arranged on the connecting plate to provide reliable mounting points, thereby improving the overall structural stiffness of the nano mixer and effectively solving the problem that when the current pushing assembly pushes the push rod of a large-capacity syringe, jitter occurs due to the increased pushing resistance and insufficient self-structural stiffness, which in turn leads to uneven sample integration and affects the mixing effect.

[0035] Therefore, such a structural setting scheme can effectively avoid the defect that the flow rate fluctuates when injecting a large volume of aqueous or oil phase through the syringe, resulting in poor mixing effect, enabling the single mixing scheme through the syringe to be applied to relatively large-volume mixing processes, and effectively solving the problems existing in the current prior art that the large-volume mixing process must use a peristaltic pump for mixing, such as liquid residue remaining in the pump body, high cost, and difficult injection speed control. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 Stereoscopic structure diagram (one) of the nano mixer according to an embodiment of the present invention.

[0037] Figure 2 Side view of the nano mixer according to an embodiment of the present invention.

[0038] Figure 3 Stereoscopic structure diagram (two) of the nano mixer according to an embodiment of the present invention.

[0039] Figure 4 Rear view of the nano mixer according to an embodiment of the present invention.

[0040] Figure 5 Schematic diagram of the positional relationship between the lead screw assembly and the pushing assembly according to an embodiment of the present invention.

[0041] Figure 6 Schematic diagram of the positional relationship between the lead screw assembly, the pushing assembly and the connecting plate according to an embodiment of the present invention.

[0042] Figure 7 Schematic diagram of the working state of the nano mixer according to an embodiment of the present invention.

[0043] Figure 8 Schematic diagram of the structure of the pushing assembly according to an embodiment of the present invention.

[0044] Figure 9 Schematic diagram of the structure of the pusher according to an embodiment of the present invention.

[0045] Figure 10 Partial structure diagram (one) of the nano mixer at the accommodating component according to an embodiment of the present invention, where the chip is hidden.

[0046] Figure 11Schematic diagram (II) of the local structure of the nano mixer according to an embodiment of the present invention at the accommodating component, where the chip is hidden.

[0047] Description of reference numerals:

[0048] Nano mixer 100

[0049] Syringe 11

[0050] Pusher rod 111

[0051] Lead screw assembly 12

[0052] Drive motor 121

[0053] Lead screw 122

[0054] Pushing assembly 13

[0055] Slider 131

[0056] Pushing member 132, fixing member 1321, movable member 1322, connection point 1323

[0057] Pushing arm 133

[0058] Connecting plate 14

[0059] Channel 141

[0060] Chip 15

[0061] Collection assembly 16, rack 161, gear 162

[0062] Liquid collection tank 17

[0063] Accommodating component 18, accommodating space 181, entrance / exit 182

[0064] Flipping structure 19, flipping point 191

[0065] Positioning structure 20 Detailed implementation manners

[0066] Next, an embodiment will be given and the present invention will be described more clearly and completely in conjunction with the accompanying drawings.

[0067] As Figures 1-4 shown, the present invention discloses a nano mixer 100.

[0068] Specifically, as Figure 1 and Figure 2As shown, the nano mixer 100 includes a chip 15 and a syringe 11. The syringe 11 specifically includes a first syringe and a second syringe. The first syringe is used to hold a first liquid, such as an aqueous phase, and the second syringe is used to hold a second liquid, such as an oil phase. The liquids held in the two syringes 11 are different. Each syringe 11 includes a push rod 111 extending downward, and the push rod 111 is used to push the liquid held in the syringe 11 into the chip 15 to further achieve mixing. At the same time, a collection assembly 16 is provided beside the chip 15. The motor in the collection assembly 16 drives a rack 161 to move horizontally through a gear 162, so as to drive two liquid collection tanks 17 to move towards the chip 15. By moving below the outlet 15a of the chip 15, the liquid after mixing is collected. Among them, in this embodiment, the liquid collection tank 17 on the left is used to collect waste liquid, and the liquid collection tank 17 on the right is used to collect the effectively mixed solution.

[0069] Taking this embodiment as an example, the volume ratio of the aqueous phase and the oil phase set in the first syringe and the second syringe is 3:1, and the flow rate ratio is also 3:1. Therefore, the first syringe and the second syringe can use syringes with the same volume (for example, in this embodiment, Figure 1 is a side view of the nano mixer. Since the first syringe and the second syringe are arranged side by side, these two first syringes and second syringes with the same capacity are in an overlapping state in the side view), and the respective push rods are compressed at different speeds to achieve the purpose of injecting liquids with different flow rates into the chip 15. Of course, in other embodiments, the device can also use syringes with different volumes as the first syringe and the second syringe. For example, the first syringe is a 100 mL syringe with 100 mL of aqueous phase inside, and the second syringe is a 50 mL syringe with 33 mL of oil phase inside; another example is that the first syringe is a 50 mL syringe with 50 mL of aqueous phase inside, and the second syringe is a 50 mL syringe with 16.6 mL of oil phase inside; another example is that the first syringe is a 50 mL syringe with 30 mL of aqueous phase inside, and the second syringe is a 10 mL syringe with 10 mL of oil phase inside, etc.

[0070] Specifically, as Figure 2 、 Figure 3 and Figure 4 shown, the nano mixer 100 further includes a lead screw assembly 12 and a connecting plate 14. A receiving assembly 18 is provided on the side of the connecting plate 14 facing away from the lead screw assembly 12 for installing the chip 15. By setting the connecting plate 14, the lead screw assembly 12 is separated from the combination of the chip 15 and the syringe 11, as Figure 2As shown in the figure, there are two lead screw assemblies 12 in this embodiment, corresponding to two syringes 11 (the first syringe and the second syringe) respectively. A pushing assembly 13 for contacting the push rod 111 of the syringe 11 is provided on each lead screw assembly 12. Among them, the connection relationship between the pushing assembly 13 and the lead screw assembly 12 is as Figure 5 shown, and the positional relationship between the pushing assembly 13 and the connecting plate 14 is as Figure 6 shown. Specifically, the pushing assembly 13 is driven by the lead screw assembly 12 to push the push rod 111 upward, so as to achieve the purpose of pushing the liquid to be mixed contained in the syringe 11 to the chip 15. Moreover, the side surface 12a of the lead screw assembly 12 faces the connecting plate 14 and the syringe 11.

[0071] Specifically, as Figure 2 shown, each lead screw assembly 12 in this application includes a lead screw 122 and a driving motor 121. The driving motor 121 is connected to the lead screw 122, and the pushing assembly 13 is connected to the lead screw 122. The working principle of the lead screw assembly 12 is: the driving motor 121 drives the lead screw 122 to rotate through its driving action. The lead screw 122 is threadedly connected to the slider 131 in the pushing assembly 13, so that the rotation of the lead screw 122 can drive the pushing assembly 13 provided thereon to move along the extension direction of the lead screw 122.

[0072] At the same time, the extension direction of the lead screw assembly 12 in this application is parallel to the setting direction of the syringe 11, both being the vertically upward direction, that is, the pushing assembly 13 is driven by the lead screw assembly 12 to push the push rod 111 upward to compress the internal space of the syringe 11.

[0073] As Figure 4 shown, the connecting plate 14 is arranged between the syringe 11 and the lead screw assembly 12. The lead screw assembly 12 and the chip 15 are both fixed to the connecting plate 14. Among them, a channel 141 for the pushing assembly 13 to penetrate is provided on the connecting plate 14, and the extension direction of the channel 141 is the same as the moving direction of the push rod 111.

[0074] In this embodiment, by changing the position of the lead screw assembly 12, the side surface 12a of the lead screw assembly 12 is arranged facing the syringe 11 and the connecting plate 14. Compared with the layout scheme of the lead screw assembly 12 in the prior art, the length of the pushing assembly 13 connected to the lead screw assembly 12 extending towards the syringe 11 is reduced, and thus the cantilever length L of the entire pushing assembly 13 is shortened (see Figure 6 ), the stability of the pushing assembly 13 during the process of pushing the push rod 111 of the syringe 11 is improved, and the structural bending and swinging during the pushing process are reduced compared with the prior art solution by shortening the cantilever length of the pushing assembly 13.

[0075] Meanwhile, the lead screw assembly 12 and the chip 15 are respectively connected to the connecting plate 14 to provide reliable mounting points through the connecting plate 14, thereby improving the overall structural stiffness of the nano mixer 100 and effectively solving the problem that the current driving assembly 13 shakes due to the increased driving resistance and insufficient self-structural stiffness when pushing the push rod 111 of the large-capacity syringe 11, which in turn leads to uneven sample integration and affects the mixing effect. Specifically, in this embodiment, as Figure 1 shown, the shape of the connecting plate 14 is not merely a flat plate structure, but a "U" - shaped structure including 90° flanges on the left and right sides. By respectively arranging flanges on the left and right sides of the connecting plate 14, the stiffness of the entire connecting plate 14 is further strengthened to ensure stability during the mixing process.

[0076] As Figure 7 shown, after the nano mixer 100 starts to work, the two lead screw assemblies 12 respectively drive the corresponding driving assemblies 13 to move along the Figure 7 push direction A shown in the figure, and then respectively push the push rods 111 of the two syringes 11, so as to respectively push the first liquid in the first syringe and the second liquid in the second syringe into the chip 15 to achieve the purpose of mixing. Among them, in this embodiment, the upward moving stroke and speed of the two lead screw assemblies 12 driving the driving assemblies 13 are matched according to the actual flow rate ratio of the two syringes 11 (for example, 3:1). However, in other embodiments, the two lead screw assemblies 12 can also adjust their respective strokes and speeds according to the actual requirements of other different flow rate ratios to meet the propulsion flow rate requirements during actual mixing.

[0077] Therefore, such a structural setting scheme can effectively avoid the defect that the syringe 11 has flow rate fluctuations when injecting a large volume of aqueous or oil phase, resulting in poor mixing effect. It can be applied to syringes with a volume of 20 mL to 100 mL, so that a single - injection mixing scheme through the syringe 11 can also be applied to relatively large - volume mixing processes, effectively solving the problems existing in the current prior art that large - volume mixing processes must use peristaltic pumps for mixing, such as liquid residue in the pump body, high cost, and difficult injection speed control.

[0078] In this embodiment, the nano mixer 100 can be automatically controlled through the driving motor 121, which increases the intelligence and remote control ability of the nano mixer 100. Moreover, through the driving motor 121, the speed and position of the driving assembly 13 moving along the lead screw assembly 12 can be precisely controlled to achieve a predetermined translation distance and speed. At the same time, the driving motor 121 can provide a stable driving force, reduce the unstable factors of manual operation, and ensure the stability and consistency of driving the driving assembly 13 each time, so as to ensure the uniformity and stability of the syringe 11 pushing out the liquid to be mixed. In addition, the automatically driven nano mixer 100 can improve the experimental efficiency.

[0079] In this embodiment, as Figure 5 and Figure 8 shown, the pushing assembly 13 includes a slider 131, a pushing arm 133, and a pusher 132. Among them, the slider 131 is arranged on the lead screw assembly 12 and moves up and down under the driving action of the lead screw assembly 12, that is, the slider 131 is arranged on the lead screw 122 and moves along the extension direction of the lead screw 122. The pusher 132 is arranged close to the push rod 111, is connected to the slider 131 through the pushing arm 133, and drives the push rod 111 to move upward under the driving of the lead screw assembly 12.

[0080] In this embodiment, the slider 131 can move on the lead screw assembly 12 under the driving action of the lead screw assembly 12, and drives the pusher 132 to move upward through the pushing arm 133 connected to the slider 131, and transmits the driving force to the push rod 111 of the syringe 11, realizing a stable and consistent pushing process.

[0081] Among them, as Figure 9 shown, in this embodiment, the pusher 132 specifically includes a fixed part 1321 and a movable part 1322. The fixed part 1321 is used to connect with the pushing arm 133 to transmit the driving force, and the movable part 1322 is arranged on the fixed part 1321 and is used to contact the push rod 111. Among them, the movable part 1322 and the fixed part 1321 are pivotally connected, and the specific connection point is Figure 9 the pivot connection part 1323 in Figure 9 Through this connection method, the movable part 1322 can perform an up-and-down flipping motion relative to the fixed part 1321 in the direction indicated by the arrow in

[0082] Specifically, in this embodiment, the lead screw assembly 12 and the connecting plate 14 are detachably connected by screws. By using screws to connect the lead screw assembly 12 and the connecting plate 14, it is convenient to disassemble, assemble and replace parts, improving the maintainability of the equipment. In other embodiments, the chip 15 and the syringe 11 can also be detachably connected to the connecting plate 14 by screws.

[0083] And in this embodiment, as Figure 10 and Figure 11As shown, a receiving assembly 18 is provided on the connecting plate 14 for quickly installing and disassembling the combination of the chip 15 and the two syringes 11. Among them, the two syringes 11 in this embodiment are directly fixed at the two inlets of the chip 15. By arranging the chip 15 in the receiving space 181 of the receiving assembly 18, the purpose of quickly fixing the chip 15 and the two syringes 11 relative to the connecting plate 14, the lead screw assembly 12 and the pushing assembly 13 is achieved.

[0084] Specifically, the position of the receiving space 181 on the receiving assembly 18 in this embodiment is as Figure 10 shown. The receiving space 181 has an entrance / exit 182 for the chip 15 to enter and exit, and the orientation of the entrance / exit 182 is perpendicular to the pushing direction A of the pushing assembly 13. By making the orientation of the entrance / exit 182 perpendicular to the pushing direction A of the pushing assembly 13, it can be avoided that when the force of the pushing assembly 13 pushing the push rod 111 of the syringe 11 is transmitted to the chip 15, the component force of this force acts on the chip 15 and causes the chip 15 to leave the receiving space 181 of the receiving assembly 18. At the same time, the user can conveniently place or remove the chip 15 at the entrance / exit 182.

[0085] As Figure 10 and Figure 11 shown, the nano mixer further includes a flipping structure 19 and a positioning structure 20. Among them, the receiving assembly 18 is connected to the connecting plate 14 through the flipping structures 19 located on the left and right sides. The flipping structure 19 is pivotally connected to the receiving assembly 18 through a flipping point 191, so that the receiving assembly 18 can flip around the flipping point 191 to change the orientation of the entrance / exit 182 to be more conducive to disassembling and assembling the chip 15 (and the two syringes 11 connected to the chip 15).

[0086] At the same time, after flipping, the receiving assembly 18 must be reset to its original horizontal position for the pushing assembly 13 to compress the push rod 111. Therefore, the positioning structure 20 is provided on the receiving assembly 18, and the position of the positioning structure 20 on the receiving assembly 18 is as Figure 11As shown in the figure, it is located at the lower surface position of the accommodating component 18 and is arranged close to the connecting plate 14. It is positioned on the connecting plate 14 through the positioning structure 20 to position the orientation of the access port 182. Specifically, in this embodiment, the positioning structure 20 is arranged at the lower surface position of the accommodating component 18 and is arranged close to the connecting plate 14. The positioning structure 20 has a surface 20a perpendicular to the orientation of the access port 182. The surface 20a is abutted against the connecting plate 14 for positioning, so as to achieve the purpose of positioning the orientation of the access port 182, making the orientation of the access port 182 of the accommodating component 18 maintain a perpendicular relationship with the pushing direction A of the pushing component 13, so as to facilitate the smooth implementation of the mixing process. Of course, in other embodiments, the orientation of the access port 182 can also be positioned at other angular positions by changing the positioning relationship between the positioning structure 20 and the connecting plate 14. Among them, in this embodiment, the material of the connecting plate 14 is stainless steel. Therefore, the material of the positioning structure 20 is set to a magnetic material that can be magnetically adsorbed on the connecting plate 14, so that the positioning structure 20 is positioned on the connecting plate 14 by magnetic adsorption. This positioning method is relatively more convenient for connection and disconnection compared with other transmission positioning and fixing methods such as installing screws, which is beneficial for the accommodating component 18 to be flipped to change the orientation of the access port 182 and is convenient for disassembling and assembling the chip 15.

[0087] In addition, as Figure 11 shown, the accommodating space 181 in this embodiment is to facilitate avoiding two syringes 11 located below the chip 15 after the chip 15 is installed. Therefore, two circular avoidance openings are provided at the bottom of the accommodating space 181. The size of the avoidance opening is smaller than the size of the chip 15, so that the chip 15 will not fall out from the avoidance opening.

[0088] In other embodiments, the accommodating component 18 may not be provided, and only the chip 15 and the connecting plate 14 may be directly connected by screws.

[0089] In this embodiment, the entire nano mixer 100 is vertically arranged. Therefore, as can be seen from Figure 1 the figure, the chip 15 is arranged at the top of the syringe 11 to mix different liquids. Therefore, by pushing the push rod 111 of the syringe 11 through the pushing component 13, the liquid to be mixed in the syringe 11 can be directly integrated on the chip 15, which can improve the pushing efficiency of the syringe 11.

[0090] Among them, the upper surface of the movable member 1322 of the pushing member 132 for contacting the push rod 111 is a planar structure, and the surface area of this planar structure is not less than the contact area of the push rod in contact with it. This structural setting scheme ensures the stability of the connection between the pushing member 132 and the push rod 111 by increasing the surface area of the planar structure of the pushing member 132 for contacting the push rod 111, so that a stable and uniform force can be applied to the push rod 111 of the syringe 11 when the pushing member 132 moves upward along the pushing direction A.

[0091] Specifically, in this embodiment, the materials of the pushing assembly 13 are all steel. Compared with the prior art in which the pushing arm is made of aluminum alloy with the grade of 6061, using steel for the pushing assembly 13 in this embodiment can enhance the rigidity of the pushing assembly 13 and the stability of pushing the push rod 111 of the syringe 11, avoiding the deformation that is likely to occur when the pushing assembly 13 pushes the push rod 111, so that the lead screw assembly 12 can be in a stable state of pushing the push rod 111 for a long time, maintaining the normal progress of the experiment.

[0092] In summary, in this embodiment, as Figures 1-2 shown, the two lead screw assemblies 12 of the nano mixer 100 are symmetrically arranged, and the model specifications of the two lead screw assemblies 12 are the same. The two lead screw assemblies respectively push the first syringe and the second syringe, so that the push rods 111 of the two syringes 11 can be pushed synchronously, maintaining the consistency of pushing. Specifically, the two lead screw assemblies 12 are both arranged on the surface of the connecting plate 14 facing away from the syringe 11. The two lead screw assemblies 12 respectively pass through the channels 141 through the pushing assemblies 13 and are in partial contact with the push rods 111 of the first syringe and the second syringe respectively, so as to push the first syringe and the second syringe to inject liquid into the chip, thereby realizing the mixing of the two liquids in the chip 15.

[0093] Although the specific embodiments of the present invention have been described above, those skilled in the art should understand that this is only an example. The protection scope of the present invention is defined by the appended claims. Without departing from the principles and essence of the present invention, those skilled in the art can make various changes or modifications to these embodiments, but these changes and modifications all fall within the protection scope of the present invention.

Claims

1. A nano mixer, characterized in that, the nano mixer includes: a chip; syringes, the syringes include a first syringe and a second syringe, the first syringe is used to accommodate a first liquid, and the second syringe is used to accommodate a second liquid; the syringes include push rods for respectively pushing the first liquid and the second liquid from their respective syringes into the chip; a lead screw assembly, on which a pushing assembly in contact with the push rod is provided, the pushing assembly is driven by the lead screw assembly to push the push rod to move, the extending direction of the lead screw assembly is parallel to the setting direction of the syringes, and the side surface of the lead screw assembly faces the syringes; a connecting plate, both the lead screw assembly and the chip are fixed to the connecting plate, the syringes are arranged on the front surface of the connecting plate, the lead screw assembly is arranged on the back surface of the connecting plate, and a channel for the pushing assembly to penetrate is provided on the connecting plate, and the extending direction of the channel is the same as the moving direction of the push rod.

2. The nano mixer according to claim 1, characterized in that, the lead screw assembly includes a lead screw and a driving motor connected to the lead screw and driving the lead screw to rotate, and the pushing assembly is arranged on the lead screw to drive the lead screw by the driving motor to drive the pushing assembly to push the push rod.

3. The nano mixer according to claim 1, characterized in that, the pushing assembly includes a slider, a pushing arm and a pushing member, the slider is arranged on the lead screw assembly and is driven by the lead screw assembly, and the pushing member is connected to the slider through the pushing arm and is arranged close to the push rod.

4. The nano mixer according to claim 3, characterized in that, the pushing member includes a fixed member and a movable member, the fixed member is connected to the pushing arm, the movable member is pivotally connected to the fixed member, the upper surface of the movable member is used to contact the push rod, and a micro switch is arranged in the fixed member, and the contact of the micro switch abuts against the lower surface of the movable member upward.

5. The nano mixer according to claim 1, characterized in that, the syringe, and / or the lead screw assembly, and / or the chip are respectively detachably connected to the connecting plate by screws.

6. The nano mixer according to claim 1, characterized in that, the nano mixer further includes a containing assembly, on which a containing space for containing the chip is provided, and the containing space has an entrance and an exit for the chip to enter and exit.

7. The nano mixer according to claim 6, characterized in that, the nano mixer further includes a flipping structure and a positioning structure, the containing assembly is connected to the connecting plate through the flipping structure, and the containing assembly can flip relative to the connecting plate to change the orientation of the entrance and exit; the positioning structure is connected to the connecting plate and abuts against the containing assembly to position the orientation of the entrance and exit.

8. The nano mixer according to claim 7, characterized in that, the positioning structure is connected to the connecting plate by a magnetic attraction method.

9. The nano mixer according to claim 3, characterized in that along the moving direction of the push rod of the syringe, the contact surface between the pushing member and the push rod is a planar structure, and the surface area of the planar structure is not less than the contact area between the pushing member and the push rod.

10. The nano mixer according to any one of claims 1-9, characterized in that the material of the pushing assembly is steel.

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