Medical antibacterial hose and preparation method thereof

Abstract

The invention discloses a medical antibacterial hose and a preparation method thereof, and belongs to the technical field of hose preparation. The medical antibacterial hose comprises the following components in parts by weight: 80 parts of PVC resin; 20 to 30 parts of a plasticizer; 0.6 to 0.8 part of a lubricant; 0.4 to 0.6 part of an antibacterial agent; the antibacterial agent is a quaternized chitosan / MOF composite material, and is recorded as HTCC / Ag / Zn-BDC. The preparation method comprises the following steps: S1, preparing an antibacterial agent HTCC / Ag / Zn-BDC; s2, mixing and granulating; and S3, extrusion molding. A quaternized chitosan / MOF composite material, namely HTCC / Ag / Zn-BDC, is used as an antibacterial agent of the medical antibacterial hose, and all the components can achieve a synergistic effect, so that an excellent antibacterial effect is achieved.

Description

Technical Field

[0001] The invention relates to the technical field of hose preparation, and in particular to a medical antibacterial hose and a preparation method thereof. Background Art

[0002] Medical hoses are widely used in the field of clinical medicine, such as infusion tubes, urinary catheters, breathing tubes, drainage tubes, etc., and are an indispensable component of medical equipment. These hoses need to have good flexibility, biocompatibility, chemical resistance and mechanical strength to ensure the safety of patients and the reliability of treatment. However, traditional medical hoses are prone to breed bacteria, fungi and other microorganisms during use, which may lead to catheter-related infections (CAUTI, CRBSI, etc.), increasing the treatment risks and medical costs of patients. Therefore, the development of a medical hose with excellent antibacterial properties is of great clinical significance.

[0003] At present, the main materials for medical hoses include PVC (polyvinyl chloride), silicone, TPU (thermoplastic polyurethane), etc., each of which has certain advantages and disadvantages; PVC hoses have low cost, good flexibility, and are easy to process, but ordinary PVC does not have antibacterial properties and can easily become a breeding ground for bacteria; silicone hoses have excellent biocompatibility, but are relatively expensive, have low mechanical strength, and are easy to wear; TPU hoses have good elasticity and chemical resistance, but their antibacterial properties still need to be modified and are relatively expensive.

[0004] Currently, most antibacterial hoses on the market use surface coating technology (such as silver coating, antibiotic coating) or mixed antibacterial agents (such as nanosilver, quaternary ammonium salts) to achieve antibacterial function. However, these methods still have the following problems: insufficient antibacterial durability, the surface coating may gradually wear or dissolve during use, resulting in a decrease in antibacterial effect; biocompatibility risks, excessive release of some antibacterial agents (such as silver ions) will be toxic to cells. Summary of the invention

[0005] The present invention provides a medical antibacterial hose and a preparation method thereof, which can solve the problem of insufficient antibacterial property of the antibacterial hose in the prior art.

[0006] A medical antibacterial hose comprises the following components in parts by weight:

[0007] PVC resin: 80 parts;

[0008] Plasticizer: 20-30 parts;

[0009] Lubricant: 0.6-0.8 parts;

[0010] Antibacterial agent: 0.4-0.6 parts;

[0011] The antibacterial agent is a quaternized chitosan / MOF composite material, which is denoted as HTCC / Ag / Zn-BDC.

[0012] Furthermore, the plasticizer is one of acetyl tributyl citrate and triethyl citrate.

[0013] Furthermore, the lubricant is one of calcium stearate, zinc stearate and pentaerythritol stearate.

[0014] A method for preparing a medical antibacterial hose comprises the following steps:

[0015] S1, preparing antibacterial agent HTCC / Ag / Zn-BDC;

[0016] S2, mixing and granulation;

[0017] S3. Extrusion molding.

[0018] Furthermore, the specific steps of step S1 are:

[0019] S11, preparation of quaternized chitosan HTCC:

[0020] Dissolve chitosan in isopropanol, and adjust the pH of the chitosan solution to 8 with 1M NaOH; add hydroxypropyltrimethylammonium chloride to the chitosan solution, stir and react at a constant temperature of 60-90°C for 8-10h, then filter, wash with anhydrous ethanol, and dry to obtain quaternized chitosan, which is recorded as HTCC;

[0021] S12, preparation of HTCC / Ag / Zn-BDC:

[0022] Dissolve zinc nitrate hexahydrate in N, N-dimethylformamide to obtain solution 1; dissolve 2-aminoterephthalic acid in N, N-dimethylformamide to obtain solution 2; dissolve HTCC in N, N-dimethylformamide to obtain solution 3; mix solution 1, solution 2 and solution 3, add silver nitrate solution, heat to 120-130°C and react for 8-10 hours; after the reaction, wash with N, N-dimethylformamide solvent, filter and dry to obtain HTCC / Ag / Zn-BDC.

[0023] Furthermore, in step S11, the mass ratio of chitosan to hydroxypropyltrimethylammonium chloride is 1:3.

[0024] Furthermore, in step S12, the concentration of the silver nitrate solution is 0.6 mol / L; the usage ratio of the silver nitrate solution, zinc nitrate hexahydrate, 2-aminoterephthalic acid and HTCC is 80 mL: 7 g: 5 g: 5 g.

[0025] Furthermore, the specific steps of step S2 are:

[0026] Add PVC resin to a high-speed mixer and heat it to 60-70°C, then add plasticizer and lubricant and heat it to 100-110°C and mix for 3-5 minutes, finally add antibacterial agent and continue mixing for 3-5 minutes to obtain a mixture; add the mixture to a twin-screw extruder and extrude and granulate to obtain PVC particles.

[0027] Furthermore, the extrusion temperature of the twin-screw extruder in step S2 is 120-160°C.

[0028] Furthermore, the specific steps of step S3 are:

[0029] The PVC particles are added into a single screw extruder, heated to 160-170°C, plasticized and formed, extruded and cooled to obtain a medical antibacterial hose.

[0030] Beneficial effects of the present invention:

[0031] The present invention uses quaternized chitosan / MOF composite material, namely HTCC / Ag / Zn-BDC as an antibacterial agent for medical antibacterial hose, which has excellent antibacterial properties because:

[0032] (1) HTCC in HTCC / Ag / Zn-BDC can be quickly adsorbed on the bacterial surface, killing bacteria instantly, while Ag in the pores of Zn-BDC + Can be released gradually to achieve medium-efficiency sterilization without Ag + Excessive release can cause toxicity to cells; Zn 2+ The continuous dissolution can inhibit the regeneration of biofilm and achieve long-term bactericidal effect.

[0033] (2) -NH of 2-aminoterephthalic acid in the MOF composite Ag / Zn-BDC 2 , can form covalent bonds with the -OH or quaternary ammonium group of HTCC through Schiff base reaction or amidation reaction, enhance the bonding strength between MOF and HTCC, avoid phase separation of components, and improve the stability of the antibacterial agent; at the same time, the nanoscale pores of MOF can limit the size of Ag particles, increase the specific surface area and antibacterial efficiency. DETAILED DESCRIPTION

[0034] The specific embodiments of the present invention are described in detail below, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments.

[0035] Example 1

[0036] This embodiment provides a medical antibacterial hose, comprising the following components in parts by weight:

[0037] PVC resin: 80 parts;

[0038] Acetyl tributyl citrate: 20 parts;

[0039] Calcium stearate: 0.6 parts;

[0040] Antimicrobial agent HTCC / Ag / Zn-BDC: 0.4 parts;

[0041] Prepared by the following steps:

[0042] S1, preparing antibacterial agent HTCC / Ag / Zn-BDC;

[0043] S11, preparation of quaternized chitosan HTCC:

[0044] 1 g of chitosan was dissolved in isopropanol, and the pH of the chitosan solution was adjusted to 8 with 1 M NaOH; 3 g of hydroxypropyltrimethylammonium chloride was added to the chitosan solution, and the mixture was stirred at 90°C for 8 h, and then filtered, washed with anhydrous ethanol, and dried to obtain quaternized chitosan, which was recorded as HTCC;

[0045] S12, preparation of HTCC / Ag / Zn-BDC:

[0046] 7 g of zinc nitrate hexahydrate was dissolved in N, N-dimethylformamide to obtain solution 1; 5 g of 2-aminoterephthalic acid was dissolved in N, N-dimethylformamide to obtain solution 2; 5 g of HTCC was dissolved in N, N-dimethylformamide to obtain solution 3; solution 1, solution 2 and solution 3 were mixed, 80 mL of 0.6 mol / L silver nitrate solution was added, and the mixture was heated to 130°C and reacted for 8 h; after the reaction was completed, the mixture was washed with N, N-dimethylformamide solvent, filtered and dried to obtain HTCC / Ag / Zn-BDC;

[0047] S2, mixing and granulation;

[0048] Add PVC resin to a high-speed mixer and heat it to 65°C, then add acetyl tributyl citrate and calcium stearate and heat it to 110°C and mix for 5 minutes, and finally add HTCC / Ag / Zn-BDC and continue mixing for 5 minutes to obtain a mixture; add the mixture to a twin-screw extruder, extrude and granulate at 140°C to obtain PVC particles;

[0049] S3, extrusion molding:

[0050] The PVC particles are added into a single screw extruder, heated to 160°C, plasticized, extruded and cooled to obtain a medical antibacterial hose.

[0051] Example 2

[0052] This embodiment provides a medical antibacterial hose, comprising the following components in parts by weight:

[0053] PVC resin: 80 parts;

[0054] Acetyl tributyl citrate: 25 parts;

[0055] Calcium stearate: 0.7 parts;

[0056] Antimicrobial agent HTCC / Ag / Zn-BDC: 0.4 parts;

[0057] Prepared by the following steps:

[0058] S1, preparing antibacterial agent HTCC / Ag / Zn-BDC;

[0059] S11, preparation of quaternized chitosan HTCC:

[0060] 1 g of chitosan was dissolved in isopropanol, and the pH of the chitosan solution was adjusted to 8 with 1 M NaOH; 3 g of hydroxypropyltrimethylammonium chloride was added to the chitosan solution, and the mixture was stirred at 90°C for 8 h, and then filtered, washed with anhydrous ethanol, and dried to obtain quaternized chitosan, which was recorded as HTCC;

[0061] S12, preparation of HTCC / Ag / Zn-BDC:

[0062] 7 g of zinc nitrate hexahydrate was dissolved in N, N-dimethylformamide to obtain solution 1; 5 g of 2-aminoterephthalic acid was dissolved in N, N-dimethylformamide to obtain solution 2; 5 g of HTCC was dissolved in N, N-dimethylformamide to obtain solution 3; solution 1, solution 2 and solution 3 were mixed, 80 mL of 0.6 mol / L silver nitrate solution was added, and the mixture was heated to 130°C and reacted for 8 h; after the reaction was completed, the mixture was washed with N, N-dimethylformamide solvent, filtered and dried to obtain HTCC / Ag / Zn-BDC;

[0063] S2, mixing and granulation;

[0064] Add PVC resin to a high-speed mixer and heat it to 65°C, then add acetyl tributyl citrate and calcium stearate and heat it to 110°C and mix for 5 minutes, and finally add HTCC / Ag / Zn-BDC and continue mixing for 5 minutes to obtain a mixture; add the mixture to a twin-screw extruder, extrude and granulate at 140°C to obtain PVC particles;

[0065] S3, extrusion molding:

[0066] The PVC particles are added into a single screw extruder, heated to 160°C, plasticized, extruded and cooled to obtain a medical antibacterial hose.

[0067] Example 3

[0068] This embodiment provides a medical antibacterial hose, comprising the following components in parts by weight:

[0069] PVC resin: 80 parts;

[0070] Acetyl tributyl citrate: 30 parts;

[0071] Calcium stearate: 0.8 parts;

[0072] Antimicrobial agent HTCC / Ag / Zn-BDC: 0.4 parts;

[0073] Prepared by the following steps:

[0074] S1, preparing antibacterial agent HTCC / Ag / Zn-BDC;

[0075] S11, preparation of quaternized chitosan HTCC:

[0076] 1 g of chitosan was dissolved in isopropanol, and the pH of the chitosan solution was adjusted to 8 with 1 M NaOH; 3 g of hydroxypropyltrimethylammonium chloride was added to the chitosan solution, and the mixture was stirred at 90°C for 8 h, and then filtered, washed with anhydrous ethanol, and dried to obtain quaternized chitosan, which was recorded as HTCC;

[0077] S12, preparation of HTCC / Ag / Zn-BDC:

[0078] 7 g of zinc nitrate hexahydrate was dissolved in N, N-dimethylformamide to obtain solution 1; 5 g of 2-aminoterephthalic acid was dissolved in N, N-dimethylformamide to obtain solution 2; 5 g of HTCC was dissolved in N, N-dimethylformamide to obtain solution 3; solution 1, solution 2 and solution 3 were mixed, 80 mL of 0.6 mol / L silver nitrate solution was added, and the mixture was heated to 130°C and reacted for 8 h; after the reaction was completed, the mixture was washed with N, N-dimethylformamide solvent, filtered and dried to obtain HTCC / Ag / Zn-BDC;

[0079] S2, mixing and granulation;

[0080] Add PVC resin to a high-speed mixer and heat it to 65°C, then add acetyl tributyl citrate and calcium stearate and heat it to 110°C and mix for 5 minutes, and finally add HTCC / Ag / Zn-BDC and continue mixing for 5 minutes to obtain a mixture; add the mixture to a twin-screw extruder, extrude and granulate at 140°C to obtain PVC particles;

[0081] S3, extrusion molding:

[0082] The PVC particles are added into a single screw extruder, heated to 160°C, plasticized, extruded and cooled to obtain a medical antibacterial hose.

[0083] Example 4

[0084] This embodiment provides a medical antibacterial hose, comprising the following components in parts by weight:

[0085] PVC resin: 80 parts;

[0086] Acetyl tributyl citrate: 30 parts;

[0087] Calcium stearate: 0.8 parts;

[0088] Antimicrobial agent HTCC / Ag / Zn-BDC: 0.5 parts;

[0089] Prepared by the following steps:

[0090] S1, preparing antibacterial agent HTCC / Ag / Zn-BDC;

[0091] S11, preparation of quaternized chitosan HTCC:

[0092] 1 g of chitosan was dissolved in isopropanol, and the pH of the chitosan solution was adjusted to 8 with 1 M NaOH; 3 g of hydroxypropyltrimethylammonium chloride was added to the chitosan solution, and the mixture was stirred at 90°C for 8 h, and then filtered, washed with anhydrous ethanol, and dried to obtain quaternized chitosan, which was recorded as HTCC;

[0093] S12, preparation of HTCC / Ag / Zn-BDC:

[0094] 7 g of zinc nitrate hexahydrate was dissolved in N, N-dimethylformamide to obtain solution 1; 5 g of 2-aminoterephthalic acid was dissolved in N, N-dimethylformamide to obtain solution 2; 5 g of HTCC was dissolved in N, N-dimethylformamide to obtain solution 3; solution 1, solution 2 and solution 3 were mixed, 80 mL of 0.6 mol / L silver nitrate solution was added, and the mixture was heated to 130°C and reacted for 8 h; after the reaction was completed, the mixture was washed with N, N-dimethylformamide solvent, filtered and dried to obtain HTCC / Ag / Zn-BDC;

[0095] S2, mixing and granulation;

[0096] Add PVC resin to a high-speed mixer and heat it to 65°C, then add acetyl tributyl citrate and calcium stearate and heat it to 110°C and mix for 5 minutes, and finally add HTCC / Ag / Zn-BDC and continue mixing for 5 minutes to obtain a mixture; add the mixture to a twin-screw extruder, extrude and granulate at 140°C to obtain PVC particles;

[0097] S3, extrusion molding:

[0098] The PVC particles are added into a single screw extruder, heated to 160°C, plasticized, extruded and cooled to obtain a medical antibacterial hose.

[0099] Example 5

[0100] This embodiment provides a medical antibacterial hose, comprising the following components in parts by weight:

[0101] PVC resin: 80 parts;

[0102] Acetyl tributyl citrate: 30 parts;

[0103] Calcium stearate: 0.8 parts;

[0104] Antimicrobial agent HTCC / Ag / Zn-BDC: 0.6 parts;

[0105] Prepared by the following steps:

[0106] S1, preparing antibacterial agent HTCC / Ag / Zn-BDC;

[0107] S11, preparation of quaternized chitosan HTCC:

[0108] 1 g of chitosan was dissolved in isopropanol, and the pH of the chitosan solution was adjusted to 8 with 1 M NaOH; 3 g of hydroxypropyltrimethylammonium chloride was added to the chitosan solution, and the mixture was stirred at 90°C for 8 h, and then filtered, washed with anhydrous ethanol, and dried to obtain quaternized chitosan, which was recorded as HTCC;

[0109] S12, preparation of HTCC / Ag / Zn-BDC:

[0110] 7 g of zinc nitrate hexahydrate was dissolved in N, N-dimethylformamide to obtain solution 1; 5 g of 2-aminoterephthalic acid was dissolved in N, N-dimethylformamide to obtain solution 2; 5 g of HTCC was dissolved in N, N-dimethylformamide to obtain solution 3; solution 1, solution 2 and solution 3 were mixed, 80 mL of 0.6 mol / L silver nitrate solution was added, and the mixture was heated to 130°C and reacted for 8 h; after the reaction was completed, the mixture was washed with N, N-dimethylformamide solvent, filtered and dried to obtain HTCC / Ag / Zn-BDC;

[0111] S2, mixing and granulation;

[0112] Add PVC resin to a high-speed mixer and heat it to 65°C, then add acetyl tributyl citrate and calcium stearate and heat it to 110°C and mix for 5 minutes, and finally add HTCC / Ag / Zn-BDC and continue mixing for 5 minutes to obtain a mixture; add the mixture to a twin-screw extruder, extrude and granulate at 140°C to obtain PVC particles;

[0113] S3, extrusion molding:

[0114] The PVC particles are added into a single screw extruder, heated to 160°C, plasticized, extruded and cooled to obtain a medical antibacterial hose.

[0115] Comparative Example 1

[0116] This comparative example provides a medical antibacterial hose, comprising the following components in parts by weight:

[0117] PVC resin: 80 parts;

[0118] Acetyl tributyl citrate: 20 parts;

[0119] Calcium stearate: 0.6 parts;

[0120] Antimicrobial agent CS / Ag / Zn-BDC: 0.4 parts;

[0121] Prepared by the following steps:

[0122] S1, preparing antibacterial agent CS / Ag / Zn-BDC;

[0123] 7 g of zinc nitrate hexahydrate was dissolved in N, N-dimethylformamide to obtain solution 1; 5 g of 2-aminoterephthalic acid was dissolved in N, N-dimethylformamide to obtain solution 2; 5 g of CS was dissolved in N, N-dimethylformamide to obtain solution 3; solution 1, solution 2 and solution 3 were mixed, 80 mL of 0.6 mol / L silver nitrate solution was added, the temperature was raised to 130°C and the reaction was carried out for 8 hours; after the reaction was completed, CS / Ag / Zn-BDC was obtained by washing with N, N-dimethylformamide solvent, filtering and drying;

[0124] S2, mixing and granulation;

[0125] Add PVC resin to a high-speed mixer and heat it to 65°C, then add acetyl tributyl citrate and calcium stearate and heat it to 110°C and mix for 5 minutes, and finally add CS / Ag / Zn-BDC and continue mixing for 5 minutes to obtain a mixture; add the mixture to a twin-screw extruder, extrude and granulate at 140°C to obtain PVC particles;

[0126] S3, extrusion molding:

[0127] The PVC particles are added into a single screw extruder, heated to 160°C, plasticized, extruded and cooled to obtain a medical antibacterial hose.

[0128] Comparative Example 2

[0129] This comparative example provides a medical antibacterial hose, comprising the following components in parts by weight:

[0130] PVC resin: 80 parts;

[0131] Acetyl tributyl citrate: 20 parts;

[0132] Calcium stearate: 0.6 parts;

[0133] Antibacterial agent Ag / Zn-BDC: 0.4 parts;

[0134] Prepared by the following steps:

[0135] S1, preparing antibacterial agent Ag / Zn-BDC;

[0136] 7 g of zinc nitrate hexahydrate was dissolved in N, N-dimethylformamide to obtain solution 1; 5 g of 2-aminoterephthalic acid was dissolved in N, N-dimethylformamide to obtain solution 2; solution 1 and solution 2 were mixed, 80 mL of 0.6 mol / L silver nitrate solution was added, and the mixture was heated to 130° C. to react for 8 h; after the reaction was completed, the mixture was washed with N, N-dimethylformamide solvent, filtered, and dried to obtain Ag / Zn-BDC;

[0137] S2, mixing and granulation;

[0138] Add PVC resin to a high-speed mixer and heat it to 65°C, then add acetyl tributyl citrate and calcium stearate and heat it to 110°C and mix for 5 minutes, and finally add Ag / Zn-BDC and continue mixing for 5 minutes to obtain a mixture; add the mixture to a twin-screw extruder, extrude and granulate at 140°C to obtain PVC particles;

[0139] S3, extrusion molding:

[0140] The PVC particles are added into a single screw extruder, heated to 160°C, plasticized, extruded and cooled to obtain a medical antibacterial hose.

[0141] The medical antibacterial hoses obtained in Examples 1 to 5 and Comparative Examples 1 to 2 were subjected to antibacterial tests, and the test results are shown in Table 1.

[0142] Table 1

[0143]

[0144] It can be seen from Table 1 that the medical antibacterial hoses prepared in Examples 1 to 5 have excellent antibacterial properties; compared with Example 1, Comparative Example 1 prepared CS / Ag / Zn-BDC as an antibacterial agent, using ordinary chitosan, and the antibacterial property of the obtained medical antibacterial hose was slightly poor; compared with Example 1, Comparative Example 2 prepared Ag / Zn-BDC as an antibacterial agent, without using quaternized chitosan HTCC, and the antibacterial property of the obtained medical antibacterial hose was also poor.

[0145] The above disclosures are only several specific embodiments of the present invention. However, the embodiments of the present invention are not limited thereto. Any changes that can be conceived by those skilled in the art should fall within the protection scope of the present invention.

Claims

1. A medical antibacterial hose, characterized in that: The composition comprises the following components in parts by weight: PVC resin: 80 parts; Plasticizer: 20-30 parts; Lubricant: 0.6-0.8 parts; Antibacterial agent: 0.4-0.6 parts; The antibacterial agent is a quaternized chitosan / MOF composite material, which is denoted as HTCC / Ag / Zn-BDC.

2. A medical antibacterial hose as claimed in claim 1, characterized in that: The plasticizer is one of acetyl tributyl citrate and triethyl citrate.

3. The medical antibacterial hose according to claim 1, characterized in that: The lubricant is one of calcium stearate, zinc stearate and pentaerythritol stearate.

4. A method for preparing a medical antibacterial hose according to any one of claims 1 to 3, characterized in that: The steps include: S1, preparing antibacterial agent HTCC / Ag / Zn-BDC; S2, mixing and granulation; S3. Extrusion molding.

5. The method for preparing a medical antibacterial hose according to claim 4, characterized in that: The specific steps of S1 are: S11, preparation of quaternized chitosan HTCC: Dissolve chitosan in isopropanol, and adjust the pH of the chitosan solution to 8 with 1M NaOH; add hydroxypropyltrimethylammonium chloride to the chitosan solution, stir and react at a constant temperature of 60-90°C for 8-10h, then filter, wash with anhydrous ethanol, and dry to obtain quaternized chitosan, which is recorded as HTCC; S12, preparation of HTCC / Ag / Zn-BDC: Dissolve zinc nitrate hexahydrate in N, N-dimethylformamide to obtain solution 1; dissolve 2-aminoterephthalic acid in N, N-dimethylformamide to obtain solution 2; dissolve HTCC in N, N-dimethylformamide to obtain solution 3; mix solution 1, solution 2 and solution 3, add silver nitrate solution, heat to 120-130°C and react for 8-10 hours; after the reaction, wash with N, N-dimethylformamide solvent, filter and dry to obtain HTCC / Ag / Zn-BDC.

6. The method for preparing a medical antibacterial hose according to claim 5, characterized in that: In step S11, the mass ratio of chitosan to hydroxypropyltrimethylammonium chloride is 1:

3.

7. The method for preparing a medical antibacterial hose according to claim 5, characterized in that: The concentration of the silver nitrate solution in step S12 is 0.6 mol / L; the usage ratio of the silver nitrate solution, zinc nitrate hexahydrate, 2-aminoterephthalic acid and HTCC is 80-100 mL: 7 g: 5 g: 5 g.

8. The method for preparing a medical antibacterial hose according to claim 4, characterized in that: The specific steps of S2 are: Add PVC resin to a high-speed mixer and heat it to 60-70°C, then add plasticizer and lubricant and heat it to 100-110°C and mix for 3-5 minutes, finally add antibacterial agent and continue mixing for 3-5 minutes to obtain a mixture; add the mixture to a twin-screw extruder and extrude and granulate to obtain PVC particles.

9. The method for preparing a medical antibacterial hose according to claim 8, characterized in that: The extrusion temperature of the twin-screw extruder in step S2 is 120-160°C.

10. The method for preparing a medical antibacterial hose according to claim 4, characterized in that: The specific steps of S3 are: The PVC particles are added into a single screw extruder, heated to 160-170°C, plasticized and formed, extruded and cooled to obtain a medical antibacterial hose.

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