Selector valve and valve path system for mass spectrometry sampling

Abstract

The invention belongs to the field of mass spectrometry, and particularly relates to a selector valve for mass spectrometry sampling and a valve path system.The selector valve comprises a stator and a rotor, an input through hole of the stator and a plurality of bypass through holes are evenly formed in a circular track with an output through hole as the center at intervals, one end of an output groove of the rotor is communicated with the output through hole, and the other end of the output groove is communicated with the bypass through hole. When the output through holes are communicated with other through holes through the output grooves, the bypass grooves are communicated with different input through holes or bypass through holes, so that one communication state can be switched every time the rotor rotates by a certain angle, and the angle is a calculable fixed value. The groove bodies can be matched with the through holes in the stator to form various communication states when the rotor rotates, combination of various flow path communication modes can be achieved, use is convenient, the rotating angle needed by the rotor can be calculated in advance, convenient and accurate control is achieved, and use convenience is further improved.

Description

Technical Field

[0001] The present invention relates to the field of mass spectrometry analysis, and particularly to a selection valve and a valve circuit system for mass spectrometry analysis injection. Background Art

[0002] When performing mass spectrometry analysis on a sample, an injection valve circuit is required, and a valve circuit system based on a multi-way selection valve is often involved. The existing selection valve has limited control or switching ability for the flow path, resulting in inconvenient use. Summary of the Invention

[0003] To solve the above technical problems, the present invention provides a selection valve for mass spectrometry analysis injection, including:

[0004] A stator, on which an output through hole, an input through hole, and at least two bypass through holes are provided. The output through hole is used to communicate with a mass spectrometer, the input through hole is used to input a sample, and the input through hole and the bypass through holes are evenly spaced on a first track, and the first track is a circular track centered on the output through hole;

[0005] A rotor, which can rotate relative to the stator around the axis of the output through hole. On the surface of the rotor facing the stator, an output groove and a plurality of bypass grooves are provided. One end of the output groove communicates with the output through hole, and the other end of the output groove falls on the first track and communicates with the input through hole or the bypass through hole as the rotor rotates. Both ends of the bypass groove fall on the first track and communicate with the input through hole and / or the bypass through hole as the rotor rotates;

[0006] Wherein, when one end of the output groove on the first track communicates with the input through hole or the bypass through hole, both ends of the bypass groove communicate with the input through hole and / or the bypass through hole.

[0007] Preferably, the length of the bypass groove is equal to the spacing between adjacent bypass through holes.

[0008] Preferably, the rotor is driven by a servo motor.

[0009] Preferably, both the stator and the rotor are disc-shaped, and the stator, the rotor, and the output through hole are coaxially arranged.

[0010] Preferably, a positioning boss extending along the axis is provided on the end face of the rotor close to the stator, and a positioning groove cooperating with the positioning boss is provided on the end face of the stator close to the rotor, and both the positioning boss and the positioning groove are concentric with the stator.

[0011] Preferably, both the output slot and the bypass slots are formed on the end face of the rotor on the side facing the stator.

[0012] On the other hand, the present invention also provides a valve circuit system for mass spectrometry injection, including the above-mentioned selection valve, and further including an input pipeline, an output pipeline, and at least one bypass pipeline. The input pipeline connects the input through-hole with the injection unit, the output pipeline connects the output through-hole with the mass spectrometer, the bypass pipeline connects two of the bypass through-holes, and a first chromatographic column and a second chromatographic column are respectively arranged on the input pipeline and at least one of the bypass pipelines.

[0013] Preferably, the number of through-holes evenly spaced on the first trajectory is ten, including the input through-hole. From the adjacent position on one side of the input through-hole to the adjacent position on the other side, they are successively the first bypass through-hole, the second bypass through-hole, the third bypass through-hole, the fourth bypass through-hole, the fifth bypass through-hole, the sixth bypass through-hole, the seventh bypass through-hole, the eighth bypass through-hole, and the waste liquid through-hole.

[0014] Among them, the first bypass through-hole and the eighth bypass through-hole are connected by the bypass pipeline and are provided with a second chromatographic column. The second bypass through-hole and the fifth bypass through-hole are connected by the bypass pipeline and are provided with a third chromatographic column. The third bypass through-hole and the sixth bypass through-hole are connected by the bypass pipeline.

[0015] There are four bypass slots, namely the first bypass slot, the second bypass slot, the third bypass slot, and the fourth bypass slot. The rotor is configured such that when the output slot connects the eighth bypass through-hole and the output through-hole, the first bypass slot connects the input through-hole and the first bypass through-hole, the second bypass slot connects the second bypass through-hole and the third bypass through-hole, the third bypass slot connects the fourth bypass through-hole and the fifth bypass through-hole, and the fourth bypass slot connects the sixth bypass through-hole and the seventh bypass through-hole.

[0016] The injection unit includes a first pump and a second pump. The first pump is connected to the input through-hole through the input pipeline, and the second pump is connected to the seventh bypass through-hole. The waste liquid through-hole is connected to a first waste liquid pool, and the fourth bypass through-hole is connected to a second waste liquid pool.

[0017] Preferably, connectors are provided at the ends of the output through-hole, the input through-hole, and the bypass through-holes away from the rotor for detachably connecting the input pipeline, the output pipeline, and the bypass pipeline.

[0018] Preferably, the power source of the injection unit adopts a peristaltic pump or a metering pump.

[0019] Applying the technical solution provided by the present invention, the input through holes and several bypass through holes of the stator are evenly spaced on a circular trajectory centered on the output through hole. One end of the output groove of the rotor communicates with the output through hole, and the other end falls on the first trajectory. Both ends of several bypass grooves fall on the first trajectory. When the rotor rotates relative to the stator, the rotor can switch a connection state every time it rotates a certain angle, and this angle is a fixed value obtained through calculation (this angle value is 360 degrees divided by the total number of through holes on the first trajectory. For example, when the total number of input through holes and bypass through holes is ten, the rotor can switch a connection state every time it rotates 36 degrees), and in each connection state, the output through hole communicates with other through holes through the output groove, and at the same time, the bypass grooves also communicate with different input through holes or bypass through holes, so that the grooves on the rotor can cooperate with the through holes on the stator to form multiple connection states during the rotation of the rotor. On the one hand, it can realize the combination of multiple flow path connection methods, which is convenient for use. On the other hand, the angle that the rotor needs to rotate each time is a fixed value (such as 36 degrees mentioned above) or an integer multiple of this fixed value, making it more convenient to control the rotation of the rotor and further improving the convenience of use. Description of the Drawings

[0020] Figure 1 is a schematic structural diagram of a selection valve for mass spectrometry injection provided by an embodiment of the present invention;

[0021] Figure 2 is a schematic structural diagram of a stator of a selection valve for mass spectrometry injection provided by an embodiment of the present invention;

[0022] Figure 3 is a schematic structural diagram of a rotor of a selection valve for mass spectrometry injection provided by an embodiment of the present invention;

[0023] Figure 4 is a schematic diagram of another structure of a rotor of a selection valve for mass spectrometry injection provided by an embodiment of the present invention;

[0024] Figure 5 is a schematic diagram of a valve path system for mass spectrometry injection in one connection state provided by an embodiment of the present invention;

[0025] Figure 6 is a schematic diagram of a valve path system for mass spectrometry injection in one connection state provided by an embodiment of the present invention;

[0026] Figure 7 is a schematic diagram of a valve path system for mass spectrometry injection in one connection state provided by an embodiment of the present invention;

[0027] Figure 8 is a schematic structural diagram of a selection valve for mass spectrometry injection provided by an embodiment of the present invention;

[0028] Among them, 1 is a selection valve; 11 is a stator; 111 is an output through-hole; 112 is an input through-hole; 113 is a bypass through-hole; 1131 is a first bypass through-hole; 1132 is a second bypass through-hole; 1133 is a third bypass through-hole; 1134 is a fourth bypass through-hole; 1135 is a fifth bypass through-hole; 1136 is a sixth bypass through-hole; 1137 is a seventh bypass through-hole; 1138 is an eighth bypass through-hole; 114 is a positioning groove; 115 is a waste liquid through-hole; 12 is a rotor; 121 is an output groove; 122 is a bypass groove; 1221 is a first bypass groove; 1222 is a second bypass groove; 1223 is a third bypass groove; 1224 is a fourth bypass groove; 123 is a positioning boss; 124 is a first groove; 125 is a second groove; 126 is a groove connection hole; 2 is a pipeline; 21 is an output pipeline; 22 is an input pipeline; 23 is a bypass pipeline; 3 is a mass spectrometer; 41 is a first pump; 42 is a second pump; 51 is a first waste liquid pool; 52 is a second waste liquid pool; 61 is a first chromatographic column; 62 is a second chromatographic column; 63 is a third chromatographic column. Specific embodiments

[0029] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Apparently, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0030] Figure 1 It is a schematic structural diagram of a selection valve for mass spectrometry injection provided by an embodiment of the present invention; Figure 2 It is a schematic structural diagram of a stator of a selection valve for mass spectrometry injection provided by an embodiment of the present invention; Figure 3 It is a schematic structural diagram of a rotor of a selection valve for mass spectrometry injection provided by an embodiment of the present invention.

[0031] As Figures 1 to 3 shown, an embodiment of the present invention provides a selection valve for mass spectrometry injection. The selection valve 1 includes a stator 11 and a rotor 12. An output through-hole 111, an input through-hole 112, and at least two bypass through-holes 113 are provided on the stator. The output through-hole 111 is used to communicate with a mass spectrometer (not shown in the figure), and the input through-hole 112 is used to input a sample. The input through-hole 112 and the bypass through-holes 113 are evenly spaced on a first trajectory, where the first trajectory is a circular trajectory centered on the output through-hole 111. In Figure 1 the circle with a dotted line as the midline is the position schematic diagram of the first trajectory;

[0032] In Figure 1With Figure 2 In the embodiment shown, centered on the output through-hole 111, a total of ten through-holes are provided on the first track of the stator 11. One of the through-holes is the input through-hole 112, and the other nine through-holes are bypass through-holes 113. Among them, the input through-hole 112 can have the same setting method as the bypass through-hole 113, that is, the ten through-holes on the first track are exactly the same, and the only difference is that the input through-hole 112 is connected to a sample introduction source. It is also possible to set the specific structure of the input through-hole 112 to be different from that of the bypass through-hole 113, which will not be elaborated here;

[0033] The rotor 12 can rotate relative to the stator 11 around the axis of the output through-hole 111. On the surface of the rotor 12 facing the stator 11, an output groove 121 and several bypass grooves 122 are provided. One end of the output groove 121 communicates with the output through-hole 111, that is, one end of the output groove 121 is located at the rotation center of the rotor 12, and the other end of the output groove 121 falls on the first track. As the rotor 12 rotates, the other end of the output groove 121 moves along the first track, so that the other end of the output groove 121 can communicate with the input through-hole 112 or the bypass through-hole 113 respectively. Both ends of the bypass groove 122 fall on the first track. As the rotor 12 rotates, both ends of the bypass groove 122 can move along the first track and communicate between the input through-hole 112 and / or the bypass through-hole 113;

[0034] In Figure 1 With Figure 3 In the embodiment shown, the output groove 121 is a groove body extending from the position corresponding to the output through-hole 111 on the surface of the rotor 12 to the position corresponding to the first track. Four bypass grooves 122 are provided on the surface of the rotor 12 corresponding to the first track, Figure 3 The several groove bodies on the surface of the rotor 12 in Figure 1 are the long groove-like structures represented by the dotted lines connecting between the input through-hole 112 or the bypass through-hole 113;

[0035] Based on the above settings, the input through-hole 112 and the bypass through-hole 113 are evenly spaced on a circular track centered on the output through-hole 111. When the rotor 12 rotates relative to the stator 11, the rotor 12 can switch a connection state every time it rotates a certain angle, and this angle is a fixed value obtained by calculation, such as Figure 1In the illustrated embodiment, a total of ten through holes are provided on the first track of the stator 11. Thus, every time the rotor rotates 36 degrees, a connection state is switched, enabling the output groove 121 to communicate with different input through holes 112 and / or bypass through holes 113. Moreover, in each connection state, the bypass groove 122 also communicates with different input through holes 112 or bypass through holes 113 simultaneously. This allows the rotor 12 to cooperate with the stator 11 to form multiple connection states during rotation, enabling combinations of multiple flow path connection methods, which is convenient for use. Additionally, the angle by which the rotor 12 needs to rotate each time is a fixed value or an integer multiple of this fixed value, making it more convenient to control the rotation of the rotor 12 and further enhancing the convenience of use.

[0036] Among them, the rotation of the rotor 12 can be precisely controlled by components such as a servo motor. Alternatively, the angle of each rotation of the rotor can be calculated based on the total number of input through holes 112 and bypass through holes 113 on the stator, and a corresponding ratchet positioning mechanism can be set. For example, in Figure 1 the illustrated embodiment, a total of ten through holes are provided on the first track of the stator 11. After calculating that the rotor switches a connection state every time it rotates 36 degrees, a ratchet mechanism matching the rotor 12 can be set, including a ratchet disc arranged on the side of the rotor 12 away from the stator 11. On the side of the ratchet disc close to the rotor 12, protrusions extending circumferentially along the rotor 12 and gradually increasing in height are provided at intervals of 36 degrees. Each protrusion extends until the starting position of the next protrusion. A compression spring is arranged below the ratchet disc to make the ratchet disc tightly adhere to the rotor 12. A protruding positioning portion is provided on the side of the rotor 12 close to the ratchet disc. Through the cooperation of the protrusions extending circumferentially and gradually increasing in height on the ratchet disc and the positioning portion, when the positioning portion of the rotor 12 starts to rotate along the starting position of the protrusion, it can squeeze the ratchet disc and the compression spring. Moreover, every time the rotor 12 rotates 36 degrees, the positioning portion of the rotor 12 is again located at the starting position of the next protrusion. Through the setting of the ratchet positioning mechanism, even without using components such as a servo motor that can precisely output torque, the precise control of the rotation amount of the rotor 12 can be completed, reducing costs.

[0037] As Figure 1 shown, in one preferred embodiment, the length of the bypass groove 122 is equal to the spacing between adjacent bypass through holes 113. When one end of the bypass groove 122 communicates with one of the bypass through holes 113, the other end of the bypass groove 122 communicates with the bypass through hole adjacent to this bypass through hole. When the number of bypass through holes 113 and bypass grooves 122 is relatively large, setting the length of the bypass groove 122 equal to the spacing between adjacent bypass through holes 113 can more conveniently arrange the bypass grooves 122 on the rotor 12 and is also more convenient for operators to estimate the positions of the bypass grooves 122 on the rotor 12 during actual sample injection operations, making the control of the rotor 12 and the switching of the flow path of the selection valve 1 simpler and more convenient.

[0038] like Figure 2 and Figure 3 As shown, in one of the preferred embodiments, the stator 11 and the rotor 12 are both disc-shaped, and the stator 11, the rotor 12 and the output through hole 111 are coaxially arranged, which can make it easier to manufacture and assemble the stator 11 and the rotor 12. A positioning boss 123 extending along the axis can be provided on the end face of the rotor 12 close to the stator 11, and a positioning groove 114 is provided on the end face of the stator 11 close to the rotor 12. The positioning boss 123 and the positioning groove 114 are both concentrically arranged with the stator 11. The relative movement between the stator 11 and the rotor 12 can be limited by the cooperation of the positioning boss 123 and the positioning groove 114 between the stator 11 and the rotor 12, thereby ensuring the accuracy of the movement of the rotor 12.

[0039] In one of the preferred embodiments, the output groove 121 and the bypass groove 122 are both provided on the end surface of the rotor 12 close to the stator 11, which can reduce the processing and manufacturing cost of the rotor 12 and also make it easier to clean the groove body on the rotor 12 after the injection is completed.

[0040] also, Figure 4 FIG. 1 is a schematic diagram of another structure of a selector valve rotor for mass spectrometry injection provided by an embodiment of the present invention, such as Figure 4 As shown, the rotor 12 can be based on several internal surfaces parallel to its circular end surface, and a slot body is opened on each reference surface. The circular end surface of the rotor 12 close to the stator 11 is the first reference, and the first slot 124, the output slot 121, the bypass slot 122, etc. can be opened on the first reference. On the second reference inside, a second slot 125 can be opened, and slot connecting holes 126 leading to the first reference are opened at both ends of the second slot 125 for connecting to the through holes at corresponding positions on the stator 11. In this way, the path projections of the first slot 124 and the second slot 125 can be crossed but not connected to each other, so that the slot body on the rotor 12 can be switched to obtain more flow path connection states.

[0041] Furthermore, the first reference of the rotor 12 may be provided with Figure 1 The first set of slot body groups shown in the figure has other slot body groups set on other references. The slot bodies opened inside the rotor 12 are all provided with corresponding slot connecting holes. The corresponding slot connecting holes opened on other references can fall on the first track, or can be set on other tracks. In this case, through holes corresponding to the track can be set on the stator 11, which will not be elaborated here.

[0042] In addition, each through hole on the stator 11 can be a straight hole leading from the side of the stator 11 facing the rotor 12 to the side of the stator 11 away from the rotor 12, or each through hole can be arranged to extend from the side of the stator 11 facing the rotor 12 to the inside of the stator 11 and then extend radially outward to the circumferential surface of the stator 11 to form an L-shaped through hole. With such an arrangement, on the one hand, since each through hole on the stator 11 generally needs to be connected to an external pipeline, the pipelines can be connected to the circumferential surface of the stator 11, enabling the external pipelines to be arranged more dispersedly and avoiding congestion, which is more convenient for pipeline layout. On the other hand, since the circular end faces of the stator 11 and the rotor 12 are generally horizontally placed, setting the connection ports of each through hole and the external pipelines on the circumferential surface allows the external pipelines to be arranged and connected to the stator 11 in the radial direction of the stator 11, that is, the horizontal direction, which is more convenient for the circulation of the internal samples.

[0043] Figure 5 is a schematic diagram of a valve circuit system for mass spectrometry injection in one connected state provided by an embodiment of the present invention; Figure 6 is a schematic diagram of a valve circuit system for mass spectrometry injection in one connected state provided by an embodiment of the present invention; Figure 7 is a schematic diagram of a valve circuit system for mass spectrometry injection in one connected state provided by an embodiment of the present invention; Figure 8 is a schematic structural diagram of a selection valve for mass spectrometry injection provided by an embodiment of the present invention.

[0044] As Figures 5 to 8 shown, the present invention also provides a valve circuit system for mass spectrometry injection, including the above-mentioned selection valve 1. A pipeline 2 is connected to the selection valve 1. The pipeline 2 includes an input pipeline 22 for connecting the input through hole 112 and the injection unit, an output pipeline 21 for connecting the output through hole 111 and the mass spectrometer 3, and at least one bypass pipeline 23 for connecting between the bypass through holes 113. A first chromatographic column 61 and a second chromatographic column 62 are respectively arranged on the input pipeline 22 and at least one of the bypass pipelines 23;

[0045] By controlling different flow path states of the selection valve 1, it is possible to control the sample in the injection unit to directly lead to the mass spectrometer through the output pipeline 21 after entering the selection valve from the input pipeline 22 and the first chromatographic column 61, or to lead to the mass spectrometer after passing through the bypass pipeline 23 and the second chromatographic column 62, thereby realizing mass spectrometry analysis.

[0046] As Figures 5 to 8As shown, in one specific embodiment, ten through-holes are evenly spaced on the first track, including an input through-hole 112. From the adjacent position on one side of the input through-hole 112 to the adjacent position on the other side of the input through-hole 112, there are successively a first bypass through-hole 1131, a second bypass through-hole 1132, a third bypass through-hole 1133, a fourth bypass through-hole 1134, a fifth bypass through-hole 1135, a sixth bypass through-hole 1136, a seventh bypass through-hole 1137, an eighth bypass through-hole 1138, and a waste liquid through-hole 115. The first bypass through-hole 1131 and the eighth bypass through-hole 1138 are connected by a bypass pipeline and are provided with a second chromatographic column 62. The second bypass through-hole 1132 and the fifth bypass through-hole 1135 are connected by a bypass pipeline and are provided with a third chromatographic column 63. The third bypass through-hole 1133 and the sixth bypass through-hole 1136 are connected by a bypass pipeline. There are four bypass slots 122, namely a first bypass slot 1221, a second bypass slot 1222, a third bypass slot 1223, and a fourth bypass slot 1224. The rotor 12 is configured such that when the output slot 121 connects the eighth bypass through-hole 1138 and the output through-hole 111, the first bypass slot 1221 connects the input through-hole 112 and the first bypass through-hole 1131, the second bypass slot 1222 connects the second bypass through-hole 1132 and the third bypass through-hole 1133, the third bypass slot 1223 connects the fourth bypass through-hole 1134 and the fifth bypass through-hole 1135, and the fourth bypass slot 1224 connects the sixth bypass through-hole 1136 and the seventh bypass through-hole 1137. The sample injection unit includes a first pump 41 and a second pump 42. The first pump 41 is connected to the input through-hole 112 through an input pipeline 22. The second pump 42 is connected to the seventh bypass through-hole 1137. The waste liquid through-hole 115 is connected to a first waste liquid pool 51. The fourth bypass through-hole 1134 is connected to a second waste liquid pool 52.

[0047] Figures 5 to 7 Figures ,

[0047] , and Figures 5 to 7 show three different connection states of the valve path system provided in the above embodiment. Taking the detection of ultra-short-chain, short-chain, and long-chain perfluorinated compounds as an example, through the valve path system provided in this embodiment, different types of perfluorinated compounds in the sample are detected according to the chain length.

[0048] Rotate the rotor 12. As shown in Figure 5 Figure Figure 5 , the sample injection of the first pump 41 passes through the first chromatographic column 61, the input through-hole 112, the first bypass slot 1221, the first bypass through-hole 1131, the second chromatographic column 62, and the eighth bypass through-hole 1138 in sequence and finally flows to the output through-hole 111 and the chromatograph 3. Among them, since the ultra-short-chain and some short-chain perfluorinated compounds with relatively strong polarity cannot be retained on the first chromatographic column 61 (reversed-phase chromatographic column), the second chromatographic column 62 (trap column) is used to trap the drugs that are difficult to be retained by the reversed-phase chromatographic column. The remaining short-chain and long-chain perfluorinated compounds have relatively weak polarity and are retained by the first chromatographic column 61. The remaining components are discharged into the waste liquid with the mobile phase (the mass spectrometer is switched to the waste liquid discharge gear);

[0049] Rotate the rotor 12, as Figure 6 shown, change the mobile phase type of the first pump 41 to elute and separate the partially short-chain and long-chain compounds trapped by the first chromatographic column 61 with the organic phase, and then directly flow through the input through-hole 112 and the output groove 121 to the output through-hole 111, and the mass spectrometer 3 performs mass spectrometry analysis and detection, that is, the detection of the partial components retained by the first chromatographic column 61 in the first-introduced liquid phase is completed;

[0050] Rotate the rotor 12, as Figure 7 shown, the first pump 41 can introduce a cleaning solution to clean the first chromatographic column 61, and the waste liquid is discharged to the first waste liquid pool 51 through the input through-hole 112 and the second bypass groove 1222 communicating with the waste liquid through-hole 115. At the same time, the second pump 42 injects samples, and passes through the seventh bypass through-hole 1137, the first bypass groove 1221, the eighth bypass through-hole 1138, the second chromatographic column 62, the first bypass through-hole 1131, the third bypass groove 1223, the second bypass through-hole 1132, the third chromatographic column 63, the fifth bypass through-hole 1135, the output groove 121 and is connected to the output through-hole 111 and the chromatograph 3. The separation and detection of the highly polar perfluorinated compounds trapped in the second chromatographic column 62 are realized through the third chromatographic column 63 (hydrophilic interaction chromatographic column).

[0051] In one preferred embodiment, connection heads are provided on the side of the through-holes such as the output through-hole 111, the input through-hole 112, and the bypass through-hole 113 provided on the stator 11 away from the rotor 12 for detachably connecting the input pipeline 22, the output pipeline 21, the bypass pipeline 23, etc.

[0052] In one preferred embodiment, the power source of the sample injection unit uses a peristaltic pump or a metering pump.

[0053] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the embodiments, those of ordinary skill in the art should understand that any modification or equivalent replacement of the technical solutions of the present invention does not depart from the spirit and scope of the technical solutions of the present invention, and they should all be covered by the scope of the claims of the present invention.

Claims

1. A selection valve for mass spectrometry injection, characterized in that: include: A stator, wherein the stator is provided with an output through hole, an input through hole, and at least two bypass through holes, the output through hole is used to connect to a mass spectrometer, the input through hole is used to input a sample, the input through holes and the bypass through holes are evenly spaced on a first trajectory, and the first trajectory is a circular trajectory centered on the output through hole; a rotor, wherein the rotor can rotate relative to the stator around the axis of the output through hole, and an output slot and a plurality of bypass slots are provided on a side of the rotor facing the stator, one end of the output slot is connected to the output through hole, and the other end of the output slot falls on the first track and is connected to the input through hole or the bypass through hole as the rotor rotates, and both ends of the bypass slot fall on the first track and are connected to the input through hole and / or the bypass through hole as the rotor rotates; Wherein, when one end of the output slot located on the first track is connected to the input through hole or the bypass through hole, both ends of the bypass slot are connected to the input through hole and / or the bypass through hole.

2. The selector valve according to claim 1, characterized in that: The length of the bypass groove is equal to the spacing between adjacent bypass through holes.

3. The selector valve according to claim 1, characterized in that: The rotor is driven by a servo motor.

4. The selector valve according to claim 1, characterized in that: The stator and the rotor are both disc-shaped, and the stator, the rotor and the output through hole are coaxially arranged.

5. The selector valve according to claim 4, characterized in that: A positioning boss extending along the axis is arranged on the end surface of the rotor close to the stator, and a positioning groove cooperating with the positioning boss is arranged on the end surface of the stator close to the rotor, and both the positioning boss and the positioning groove are concentric with the stator.

6. The selector valve according to claim 1, characterized in that: The output groove and the bypass groove are both arranged on the end surface of the rotor on the side close to the stator.

7. A valve system for mass spectrometry analysis injection, comprising the selection valve according to any one of claims 1 to 6, characterized in that: It also includes an input pipeline, an output pipeline and at least one bypass pipeline, the input pipeline connects the input through hole and the injection unit, the output pipeline connects the output through hole and the mass spectrometer, the bypass pipeline connects two of the bypass through holes, and a first chromatographic column and a second chromatographic column are respectively arranged on the input pipeline and at least one of the bypass pipelines.

8. The valve circuit system according to claim 7, characterized in that: The number of through holes evenly spaced on the first track is ten, including the input through hole, and from the adjacent position on one side of the input through hole to the adjacent position on the other side are the first bypass through hole, the second bypass through hole, the third bypass through hole, the fourth bypass through hole, the fifth bypass through hole, the sixth bypass through hole, the seventh bypass through hole, the eighth bypass through hole and the waste liquid through hole; Wherein, the first bypass through hole is connected to the eighth bypass through hole through the bypass pipeline and is provided with a second chromatographic column, the second bypass through hole is connected to the fifth bypass through hole through the bypass pipeline and is provided with a third chromatographic column, and the third bypass through hole is connected to the sixth bypass through hole through the bypass pipeline; The bypass grooves are provided with four, namely, a first bypass groove, a second bypass groove, a third bypass groove and a fourth bypass groove, and the rotor is configured such that when the output groove is connected with the eighth bypass through hole and the output through hole, the first bypass groove is connected with the input through hole and the first bypass through hole, the second bypass groove is connected with the second bypass through hole and the third bypass through hole, the third bypass groove is connected with the fourth bypass through hole and the fifth bypass through hole, and the fourth bypass groove is connected with the sixth bypass through hole and the seventh bypass through hole; The injection unit includes a first pump and a second pump, the first pump is connected to the input through hole through the input pipeline, and the second pump is connected to the seventh bypass through hole; the waste liquid through hole is connected to the first waste liquid tank, and the fourth bypass through hole is connected to the second waste liquid tank.

9. The valve circuit system according to claim 7, characterized in that: A connector is provided at one end of the output through hole, the input through hole and the bypass through hole away from the rotor, and is used for detachably connecting the input pipe, the output pipe and the bypass pipe.

10. The valve circuit system according to claim 7, characterized in that: The power source of the sample injection unit is a peristaltic pump or a quantitative pump.

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