Knife and gun wound medicine as well as preparation method and application thereof

Abstract

The invention relates to a knife-gun wound medicine and a preparation method and application thereof, in particular to the technical field of traditional Chinese medicine. The medicine is prepared from the following raw materials in parts by weight: 300 to 700 parts of herba hyperici japonici, 200 to 400 parts of folium artemisiae argyi, 300 to 600 parts of fructus rosae laevigatae, 200 to 500 parts of radix cyathulae, 300 to 500 parts of elephantopus scaber, 300 to 700 parts of herba andrographitis, 100 to 500 parts of lycopodium clavatum, 400 to 700 parts of radix angelicae sinensis and 300 to 400 parts of fructus lycii. Natural Chinese herbal medicines are adopted as raw materials, the traditional Chinese medicine composition has the effects of clearing heat, promoting diuresis, detoxifying, dissipating stasis, diminishing swelling, relieving pain, relieving itching, sterilizing, treating skin diseases, tonifying yang and deodorizing, wound healing is fast after the traditional Chinese medicine composition is used, and traces caused by the medicine cannot be left around the wound.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a medicine for knife and gun wounds, a preparation method thereof and an application thereof. Background Art

[0002] Wound is a common skin trauma. Wound healing refers to the healing process after skin tissue is severed or damaged due to external forces such as knife wounds and trauma, including the complex combination of regeneration of various tissues, granulation tissue hyperplasia, and scar tissue formation. Mild trauma is limited to the damage of the epidermal layer of the skin. Generally, it can heal through epithelial regeneration, that is, through different degrees of tissue necrosis, blood vessel rupture and bleeding, and local swelling at the wound site. The fibrinogen in the blood and exudate in the wound coagulates to form a clot. Some clots dry on the surface to form a scab to protect the wound. Then the wound shrinks, granulation tissue hyperplasia and scar formation occur. The collagen fibers in the scar finally become parallel to the skin surface until the epidermis and other tissues are regenerated. The general treatment methods for such traumatic wounds are: self-healing, wound stickers, and suturing. However, as described above, the current treatment methods have the disadvantages of possible need for surgery and slow scab formation. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide a medicine for knife and gun wounds, a preparation method thereof and an application thereof. The present invention uses natural Chinese herbal medicines as raw materials, and has the effects of clearing heat and promoting diuresis, detoxifying, dispersing stasis and detumescence, relieving pain, relieving itching, sterilizing, treating skin diseases and strengthening yang. After use, the wound heals quickly and no trace caused by the medicine will be left around the wound.

[0004] The technical solution of the present invention to solve the above technical problems is as follows:

[0005] The first object of the present invention is to provide a medicine for knife and gun wounds, which comprises the following raw materials in parts by weight: 300-700 parts of Hypericum japonicum Thunb., 200-400 parts of Artemisia argyi Levl. et Vant., 300-600 parts of Rosa laevigata Michx. fruit, 200-500 parts of Cyathula officinalis Kuan, 300-500 parts of Elephantopus scaber L., 300-700 parts of Andrographis paniculata (Burm.f.) Nees, 100-500 parts of Lycopodium clavatum L., 400-700 parts of Angelica sinensis (Oliv.) Diels, 300-400 parts of Lycium barbarum L.

[0006] Hypericum japonicum Thunb.: Hypericum japonicum Thunb. is the whole herb of the plant Hypericum japonicum Thunb. of the family Guttiferae. It tastes sweet and slightly bitter, and is slightly cold in nature. It belongs to the liver and spleen meridians. It has the functions of clearing heat and detoxifying, promoting diuresis and removing jaundice, dispersing stasis and detumescence. It is used for damp-heat jaundice, appendicitis, red and swollen eyes, heat-toxic sores, externally for treating carbuncles and furuncles, traumatic stasis and swelling pain, snake bites, and herpes zoster.

[0007] Artemisia argyi: The leaf of Artemisia argyi, a plant of the Compositae family. It is bitter in taste and warm in nature, and has the effects of warming the meridian to stop bleeding, dispelling cold and relieving pain, and activating blood circulation and regulating menstruation. It has good effects on various symptoms such as irregular menstruation, metrorrhagia and metrostaxis, epistaxis, gingival bleeding, abdominal pain, and infertility due to cold uterus. Externally applied, Artemisia argyi can also play a role in relieving itching and removing dampness, and can be used to relieve the skin itching symptoms caused by skin diseases such as eczema.

[0008] Fructus Rosae Laevigatae: The dried ripe fruit of Rosa laevigata Michx., a plant of the Rosaceae family. It is sour, sweet, and astringent in taste, and neutral in nature. It belongs to the kidney, bladder, and large intestine meridians. It has the effects of astringing sperm and reducing urination, preventing uterine bleeding and leukorrhea, and astringing the intestine and stopping diarrhea.

[0009] Cyathula officinalis Kuan: The dried root of Cyathula officinalis Kuan, a plant of the Amaranthaceae family. It is sweet and slightly bitter in taste, and neutral in nature. It belongs to the liver and kidney meridians. Its main effects are to purge and descend, promote blood circulation and remove stasis, and can dredge joints and promote diuresis. Clinically, it is often used to treat rheumatic arthralgia and traumatic injuries.

[0010] Elephantopus scaber Linn.: The whole herb of Elephantopus scaber Linn., a plant of the genus Elephantopus in the Compositae family. It is bitter in taste and cool in nature. It belongs to the lung, liver, and kidney meridians. It has the effects of clearing heat and detoxifying, and promoting diuresis and reducing swelling. It is commonly used in the treatment of colds, acute tonsillitis, pharyngitis, conjunctivitis, epidemic encephalitis B, whooping cough, acute icteric hepatitis, liver cirrhosis ascites, acute and chronic nephritis, furuncles, and eczema.

[0011] Andrographis paniculata (Burm. f.) Nees: The aerial part of Andrographis paniculata (Burm. f.) Nees, an annual herb of the Acanthaceae family. It is bitter in taste and cold in nature. It belongs to the lung, stomach, large intestine, and bladder meridians. It has the effects of clearing heat and detoxifying, and drying dampness and stopping dysentery.

[0012] Lygodium japonicum (Thunb.) Sw.: The aerial part of Lygodium japonicum (Thunb.) Sw., a plant of the Lygodiaceae family. It is sweet in taste and cold in nature. It belongs to the small intestine, bladder, and liver meridians, and has the effects of clearing heat and detoxifying, promoting diuresis and removing gravel, and activating blood circulation and dredging collaterals.

[0013] Angelica sinensis (Oliv.) Diels: The dried root of Angelica sinensis (Oliv.) Diels, a plant of the Umbelliferae family. It is warm in nature, sweet and pungent in taste. It belongs to the liver, heart, and large intestine meridians. It can enrich blood and activate blood circulation, regulate menstruation and relieve pain, and moisten the intestine and relieve constipation. It can be used to treat sallow complexion due to blood deficiency, palpitation and insomnia; it is an essential medicine for enriching blood and activating blood circulation, regulating menstruation and relieving pain in gynecology, and can be used to treat irregular menstruation, amenorrhea, and dysmenorrhea in women, especially those with blood deficiency; it can treat wind-cold arthralgia and limb numbness; and swelling and pain of sores and ulcers.

[0014] Lycium barbarum L.: The ripe fruit of Lycium barbarum L., a plant of the genus Lycium in the Solanaceae family. It is sweet in taste and neutral in nature. It belongs to the liver and kidney meridians, and has the effects of nourishing the liver and kidney, benefiting essence and improving eyesight, and moistening the lungs.

[0015] The beneficial effects of the present invention are as follows: The present invention uses natural Chinese herbal medicines as raw materials, and has the effects of clearing heat and promoting diuresis, detoxifying, dispersing stasis and reducing swelling, relieving pain, and relieving itching. After use, the wound heals quickly, and no trace caused by the medicine will be left around the wound.

[0016] On the basis of the above technical solutions, the present invention can also be improved as follows.

[0017] Furthermore, the sword and spear wound medicine comprises the following raw materials in parts by weight: 400 - 600 parts of Hypericum japonicum Thunb., 300 parts of Artemisia argyi Levl. et Vant., 400 - 500 parts of Rosa laevigata Michx. fruit, 300 - 400 parts of Cyathula officinalis Kuan, 350 - 400 parts of Elephantopus scaber L., 400 - 600 parts of Andrographis paniculata (Burm.f.) Nees, 200 - 450 parts of Lycopodium clavatum L., 450 - 600 parts of Angelica sinensis (Oliv.) Diels, and 350 parts of Lycium barbarum L.

[0018] Furthermore, the sword and spear wound medicine further comprises auxiliary materials.

[0019] Furthermore, the auxiliary materials include at least one of white sugar and white liquor.

[0020] The beneficial effect of adopting the above further scheme is that: in the preparation of the sword and spear wound medicine of the present invention, white sugar and white liquor are also added. The white sugar can be used to solidify the extracted liquid obtained by boiling, and the white liquor can extend the shelf life of the sword and spear wound medicine.

[0021] The second object of the present invention is to provide a preparation method of a sword and spear wound medicine, comprising the following steps:

[0022] (1) Separately boil Artemisia argyi Levl. et Vant., Lycopodium clavatum L., Angelica sinensis (Oliv.) Diels, and Lycium barbarum L. with water respectively to obtain Artemisia argyi Levl. et Vant. extract, Lycopodium clavatum L. extract, Angelica sinensis (Oliv.) Diels extract, and Lycium barbarum L. extract. Boil Hypericum japonicum Thunb., Rosa laevigata Michx. fruit, Cyathula officinalis Kuan, Elephantopus scaber L., and Andrographis paniculata (Burm.f.) Nees with water and white sugar respectively to obtain Hypericum japonicum Thunb. extract, Rosa laevigata Michx. fruit extract, Cyathula officinalis Kuan extract, Elephantopus scaber L. extract, and Andrographis paniculata (Burm.f.) Nees extract;

[0023] (2) Mix the Artemisia argyi Levl. et Vant. extract, the Lycopodium clavatum L. extract, the Angelica sinensis (Oliv.) Diels extract, the Lycium barbarum L. extract, the Hypericum japonicum Thunb. extract, the Rosa laevigata Michx. fruit extract, the Cyathula officinalis Kuan extract, the Elephantopus scaber L. extract, and the Andrographis paniculata (Burm.f.) Nees extract and boil until the water evaporates to obtain particles, and add white liquor to the particles to obtain the sword and spear wound medicine.

[0024] The beneficial effect of the present invention is that: the preparation steps of the present invention are simple, the raw materials are easy to obtain, and the medicinal effect can be exerted to a greater extent.

[0025] Furthermore, in step (1), the mass ratio of Hypericum japonicum Thunb. to white sugar is 400 - 600:100; the mass ratio of Rosa laevigata Michx. fruit to white sugar is 400 - 500:100; the mass ratio of Cyathula officinalis Kuan to white sugar is 300 - 400:100; the mass ratio of Elephantopus scaber L. to white sugar is 350 - 400:100; the mass ratio of Andrographis paniculata (Burm.f.) Nees to white sugar is 400 - 600:100.

[0026] Further, in step (2), the mass ratio of the particulate matter to the Chinese liquor is 25-50:500-1000, and the volume concentration of ethanol in the Chinese liquor is 40%-50%.

[0027] The third object of the present invention is to provide an application of a sword and gun wound medicine, and the sword and gun wound medicine is used for preparing a medicine for treating traumatic wounds.

[0028] Further, the traumatic wound includes a traumatic wound caused by a sword and / or a gun.

[0029] Further, the sword and gun wound medicine can also be used for preparing a medicine for treating skin diseases and / or enhancing yang.

[0030] The beneficial effect of adopting the above further scheme is that: the sword and gun wound medicine prepared by the present invention can not only reduce inflammation, stop bleeding and relieve pain, can be applied externally or taken orally, achieving different treatment effects. Applying externally can reduce inflammation, stop bleeding and relieve pain, and taking orally can strengthen the kidney. In addition, the present invention also has the effects of treating toothache, diarrhea and foot odor. Specific Embodiments

[0031] The principles and features of the present invention are described below. The examples given are only used to explain the present invention and are not intended to limit the scope of the present invention. For those not specifying specific techniques or conditions in the examples, the techniques or conditions described in the literature in the field are followed, or the product specifications are followed. For those reagents or instruments not indicating the manufacturer, they are all conventional products that can be purchased through regular channels.

[0032] Example 1: Preparation of Sword and Gun Wound Medicine I

[0033] (1) 300 parts by weight of Artemisia argyi, 325 parts by weight of Lycopodium clavatum, 525 parts by weight of Angelica sinensis, and 350 parts by weight of Lycium barbarum are separately decocted with water according to a mass ratio of 0.5:2.5 to obtain 500 ml of Artemisia argyi extract, 500 ml of Lycopodium clavatum extract, 500 ml of Angelica sinensis extract, and 500 ml of Lycium barbarum extract; 500 parts by weight of Hypericum japonicum, 450 parts by weight of Rosa laevigata, 350 parts by weight of Cyathula officinalis, 375 parts by weight of Elephantopus scaber, and 500 parts by weight of Andrographis paniculata are separately added with water according to a mass ratio of 0.5:2.5 and then 100 g of white sugar is added to each for decoction to obtain 500 ml of Hypericum japonicum extract, 500 ml of Rosa laevigata extract, 500 ml of Cyathula officinalis extract, 500 ml of Elephantopus scaber extract, and 500 ml of Andrographis paniculata extract;

[0034] (2) Mix 500 ml of Artemisia argyi extract, 500 ml of Lycopodium clavatum extract, 500 ml of Angelica sinensis extract, 500 ml of Lycium barbarum extract, 500 ml of Hypericum japonicum extract, 500 ml of Rosa laevigata fruit extract, 500 ml of Cyathula officinalis extract, 500 ml of Elephantopus scaber extract, and 500 ml of Andrographis paniculata extract, and boil until the water evaporates to obtain particulate matter. Mix the particulate matter and 50-degree baijiu in a mass ratio of 25:500 to obtain the medicine for knife and gun wounds.

[0035] Example 2: Preparation of the medicine for knife and gun wounds II

[0036] (1) Separately boil 300 parts by weight of Artemisia argyi, 200 parts by weight of Lycopodium clavatum, 450 parts by weight of Angelica sinensis, and 350 parts by weight of Lycium barbarum alone with water in a mass ratio of 0.5:2.5 to obtain 500 ml of Artemisia argyi extract, 500 ml of Lycopodium clavatum extract, 500 ml of Angelica sinensis extract, and 500 ml of Lycium barbarum extract; separately boil 400 parts by weight of Hypericum japonicum, 400 parts by weight of Rosa laevigata fruit, 300 parts by weight of Cyathula officinalis, 350 parts by weight of Elephantopus scaber, and 400 parts by weight of Andrographis paniculata alone with water in a mass ratio of 0.5:2.5, and then add 100 g of white sugar to each and boil to obtain 500 ml of Hypericum japonicum extract, 500 ml of Rosa laevigata fruit extract, 500 ml of Cyathula officinalis extract, 500 ml of Elephantopus scaber extract, and 500 ml of Andrographis paniculata extract;

[0037] (2) Mix 500 ml of Artemisia argyi extract, 500 ml of Lycopodium clavatum extract, 500 ml of Angelica sinensis extract, 500 ml of Lycium barbarum extract, 500 ml of Hypericum japonicum extract, 500 ml of Rosa laevigata fruit extract, 500 ml of Cyathula officinalis extract, 500 ml of Elephantopus scaber extract, and 500 ml of Andrographis paniculata extract, and boil until the water evaporates to obtain particulate matter. Mix the particulate matter and 50-degree baijiu in a mass ratio of 25:500 to obtain the medicine for knife and gun wounds.

[0038] Example 3: Preparation of the medicine for knife and gun wounds III

[0039] (1) Separately boil 300 parts by weight of Artemisia argyi, 450 parts by weight of Lycopodium clavatum, 600 parts by weight of Angelica sinensis, and 350 parts by weight of Lycium barbarum alone with water in a mass ratio of 0.5:2.5 to obtain 500 ml of Artemisia argyi extract, 500 ml of Lycopodium clavatum extract, 500 ml of Angelica sinensis extract, and 500 ml of Lycium barbarum extract; separately boil 600 parts by weight of Hypericum japonicum, 500 parts by weight of Rosa laevigata fruit, 400 parts by weight of Cyathula officinalis, 400 parts by weight of Elephantopus scaber, and 600 parts by weight of Andrographis paniculata alone with water in a mass ratio of 0.5:2.5, and then add 100 g of white sugar to each and boil to obtain 500 ml of Hypericum japonicum extract, 500 ml of Rosa laevigata fruit extract, 500 ml of Cyathula officinalis extract, 500 ml of Elephantopus scaber extract, and 500 ml of Andrographis paniculata extract;

[0040] (2) Mix 500 ml of Artemisia argyi extract, 500 ml of Lycopodium clavatum extract, 500 ml of Angelica sinensis extract, 500 ml of Lycium barbarum extract, 500 ml of Hypericum japonicum extract, 500 ml of Rosa laevigata fruit extract, 500 ml of Cyathula officinalis extract, 500 ml of Elephantopus scaber extract, and 500 ml of Andrographis paniculata extract, and boil until the water evaporates to obtain particulate matter. Mix the particulate matter and 50-degree white liquor according to a mass ratio of 25:500 to obtain the medicine for knife and gunshot wounds.

[0041] Experimental Example 1:

[0042] Select 400 patients with knife wounds during the period from November 2021 to November 2014 as the research objects, and randomly divide them into a control group and a treatment group, with 100 cases in each group. There are no significant differences in the average age and general information of the two groups of patients (P>0.05).

[0043] Inclusion criteria: Patients with various knife wound incisions on the body; Those with incisions that have not healed for more than 1 week; Informed consent of the patients.

[0044] Experimental method: The control group was treated with Yunnan Baiyao for comparison. After cleaning and disinfecting the incisions of the patients in the treatment group with normal saline, dip a cotton swab in the medicine of Examples 1 to 3 of the present invention and apply it evenly on the incisions. 5 days is one course of treatment, and the clinical efficacy was observed after 10 days. After 10 days, the patients in the control group who showed ineffective treatment were switched to this prescription for treatment, and the clinical efficacy was observed after 5 days.

[0045] Among them, complete healing of the incision is considered cured, reduction of the incision is considered effective, and no obvious change in the incision is considered ineffective.

[0046] Table 1

[0047] Cure rate Effective rate Total effective rate Control group 44 36 80％ Example 1 48 40 88％ Example 2 46 39 85％ Example 3 45 37 82％

[0048] It can be seen from Table 1 that

[0049] The present invention uses natural Chinese herbal medicines as raw materials, has the effects of clearing away heat and dampness, detoxifying, dissipating stasis and reducing swelling, relieving pain and itching. After use, the wound heals quickly and no trace caused by the medicine will be left around the wound.

[0050] 2. Typical cases:

[0051] (1) Male, 60 years old, the sole of the foot was scratched by an agricultural tool, and the tendons and bones were not injured. The wound scabbed after using the medicine of Example 1 for 5 days.

[0052] (2) Female, 48 years old, with gum swelling and pain. After taking the medicine of Example 1, the pain and swelling were relieved on the same day. After insisting on taking it for 1 week, she was cured and did not relapse.

[0053] (3) Male, 60 years old, suffering from athlete's foot. Apply the medicine prepared in Example 1 once a day, and he was cured and did not relapse after 1 week.

[0054] (4) Male, 36 years old, with intermittent diarrhea for half a year, having watery stools, and the pain relieved after defecation. For the diarrhea, the medicament prepared in Example 1 was taken 3 times a day and the patient was cured without recurrence after 5 days.

[0055] Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those of ordinary skill in the art can make changes, modifications, substitutions, and variations to the above embodiments within the scope of the present invention.

Claims

1. A medicine for knife and gun wounds, characterized in that: The invention comprises the following raw materials in parts by weight: 300-700 parts of Radix Achyranthis Bidentatae, 200-400 parts of Folium Artemisiae Argyi, 300-600 parts of Cherry Goldenseal, 200-500 parts of Cyathula officinalis, 300-500 parts of Herba Epimedii, 300-700 parts of Andrographis paniculatae, 100-500 parts of Herba Lycii, 400-700 parts of Radix Angelicae Sinensis and 300-400 parts of Lycium barbarum.

2. The knife and gun wound medicine according to claim 1, characterized in that: The knife and gun wound medicine comprises the following raw materials in parts by weight: 400-600 parts of Radix Achyranthis Bidentatae, 300 parts of Artemisia argyi, 400-500 parts of Cherry Goldenseal, 300-400 parts of Cyathula capitata, 350-400 parts of Herba Epimedii, 400-600 parts of Andrographis paniculata, 200-450 parts of Herba Lycii, 450-600 parts of Angelica sinensis, and 350 parts of Lycium barbarum.

3. A knife and gun wound medicine according to any one of claims 1 to 2, characterized in that: The knife and gun wound medicine also includes auxiliary materials.

4. The knife and gun wound medicine according to claim 3, characterized in that: The auxiliary material includes at least one of white sugar and white wine.

5. A method for preparing a knife and gun wound medicine according to any one of claims 1 to 4, characterized in that: The preparation method comprises the following steps: (1) Adding water to wormwood, sedge grass, Chinese angelica and wolfberry separately and boiling them to obtain wormwood extract, sedge grass extract, Chinese angelica extract and wolfberry extract; adding water and sugar to radix scutellariae, cerasifera, cyathulae, scutellariae and andrographis respectively and boiling them to obtain radix scutellariae extract, cerasifera extract, cyathulae extract, scutellariae extract and andrographis; (2) The wormwood extract, the elaeis japonica extract, the angelica extract, the wolfberry extract, the radix scutellariae extract, the cerasifera extract, the cyperus rotundus extract, the radix scutellariae extract, the cyperus rotundus extract, the radix scutellariae extract, and the andrographis paniculata extract are mixed and boiled until water evaporates to obtain granules, and white wine is added to the granules to obtain a medicine for knife and gun wounds.

6. The method for preparing a knife and gun wound medicine according to claim 5, characterized in that: In step (1), the mass ratio of the Radix Achyranthis Bidentatae to the white sugar is 400-600:100; the mass ratio of the Rhizoma Chrysanthemi Laevigatae to the white sugar is 400-500:100; the mass ratio of the Rhizoma Cynoglossi to the white sugar is 300-400:100; the mass ratio of the Herba Lycopodii to the white sugar is 350-400:100; the mass ratio of the Herba Andrographis paniculatae to the white sugar is 400-600:

100.

7. The method for preparing a knife and gun wound medicine according to claim 5, characterized in that: In step (2), the mass ratio of the particulate matter to the liquor is 25-50:500-1000, and the volume concentration of ethanol in the liquor is 40%-50%.

8. An application of a knife and gun wound medicine, characterized in that: The knife and gun wound medicine according to any one of claims 1 to 5 is used in preparing medicine for treating traumatic wounds.

9. The use of a knife and gun wound medicine according to claim 8, characterized in that: The traumatic wounds include those caused by knives and / or guns.

10. The use of a knife and gun wound medicine according to claim 8, characterized in that: The knife and gun wound medicine can also be used to prepare medicines for treating skin diseases and / or strengthening male sexual function.