Liver-clearing and dampness-resolving tea granules

Abstract

The invention relates to the field of food, and discloses a liver-clearing and dampness-resolving tea granule, which is prepared from the following raw materials in parts by weight: 8 to 12 parts of semen hoveniae, 4 to 6 parts of flos puerariae, 8 to 12 parts of poria cocos, 5 to 8 parts of pericarpium citri reticulatae, 5 to 8 parts of perilla stem, 5 to 8 parts of fructus gardeniae, 5 to 8 parts of spica prunellae, 2 to 4 parts of fructus amomi, 50 to 60 parts of xylitol, 0.2 to 0.4 part of L-malic acid and 8 to 29 parts of functional composition. The hovenia dulcis thunb and the flos puerariae are used for accelerating alcohol metabolism and relieving liver burden, the fructus gardeniae and the spica prunellae are used for clearing liver and gallbladder and tri-jiao damp-heat, the silymarin and the curcumin are used for repairing damaged hepatocytes and enhancing the detoxification capacity of the liver, the fructus amomi, the pericarpium citri reticulatae and the perilla stem are used for promoting the circulation of qi, regulating the middle warmer and relieving abdominal distension and nausea, and the poria cocos is used for tonifying spleen and promoting transportation; poria cocos, dried orange peel, perilla stem and the like regulate spleen and stomach, promote transportation and transformation functions and discharge dampness and heat in the body, and fructo-oligosaccharide and hericium erinaceus regulate intestinal flora and reduce generation of endotoxin.

Description

Technical Field

[0001] The present invention relates to the technical field of food, and specifically to a tea drink granule for clearing the liver and resolving dampness. Background Art

[0002] Under the background of the rapid development of the large health industry, functional foods have become the focus of market attention due to their dual functions of nutritional supplementation and health regulation. Among them, functional tea drink products for conditioning damp-heat constitution and protecting the liver have a continuous growing market demand due to their convenient drinking and wide audience.

[0003] In recent years, with the continuous improvement of people's living standards, functional tea drink products for conditioning damp-heat constitution and protecting the liver have shown a continuous growing trend in market demand due to their convenient drinking and wide audience. According to traditional Chinese medicine theory, damp-heat constitution is mostly caused by factors such as improper diet, excessive consumption of fatty and sweet foods, or long-term alcohol consumption, and is often manifested as symptoms such as oily face, greasy scalp, bitter mouth and dry throat, dry and astringent eyes, yellow and short urine, and sticky and unsmooth stools; moreover, the continuous damage of the liver caused by acetaldehyde produced during alcohol metabolism makes people who passively drink alcohol or drink excessively for a long time face the risk of abnormal liver function.

[0004] Traditional tea drink granules often rely on single traditional Chinese medicine ingredients or modern single active substances, mostly staying at the level of traditional Chinese medicine empirical prescriptions, and cannot improve the internal environment imbalance caused by long-term alcohol consumption or improper diet from the root of constitution conditioning, and symptoms are likely to recur. Summary of the Invention

[0005] Aiming at the deficiencies of the prior art, the present invention provides a tea drink granule for clearing the liver and resolving dampness, which solves the problem that traditional tea drink granules cannot improve the internal environment imbalance caused by long-term alcohol consumption or improper diet from the root of constitution conditioning, and symptoms are likely to recur.

[0006] To achieve the above objectives, the present invention is realized through the following technical solutions: A tea drink granule for clearing the liver and resolving dampness, comprising the following raw materials in parts by weight: 8 - 12 parts of Hovenia dulcis, 4 - 6 parts of Puerariae flos, 8 - 12 parts of Poria cocos, 5 - 8 parts of Pericarpium Citri Reticulatae, 5 - 8 parts of Caulis Perillae, 5 - 8 parts of Gardenia jasminoides Ellis, 5 - 8 parts of Spica Prunellae, 2 - 4 parts of Fructus Amomi, 50 - 60 parts of xylitol, 0.2 - 0.4 parts of L-malic acid, and 8 - 29 parts of a functional composition.

[0007] By adopting the above technical solution, based on the traditional Chinese medicine theory of "clearing the liver and resolving dampness, strengthening the spleen and harmonizing the stomach", combined with the research results of modern pharmacology, traditional anti-alcoholic medicinal materials such as Hovenia dulcis and Puerariae flos are scientifically formulated with modern liver-protecting components such as Silybum marianum and Curcuma longa, and at the same time supplemented with dampness-resolving and spleen-strengthening medicinal materials such as Poria cocos and Citrus reticulata. Through the synergistic effect of multiple traditional Chinese medicine components, it regulates the transportation and transformation function of the human spleen and stomach, promotes the excretion of damp-heat pathogens; the liver-protecting and strengthening components in the functional composition specifically protect liver cells and enhance the liver's metabolic capacity; the intestinal regulation components improve the intestinal microecology and reduce the production of endotoxins; xylitol and L-malic acid regulate the taste and improve the palatability of the product. It realizes the multi-target synergistic conditioning from "clearing the liver - resolving dampness - strengthening the spleen - protecting the liver", comprehensively improves the damp-heat constitution, repairs the damage of alcohol to the liver, and solves the problem that traditional tea granules cannot improve the internal environment imbalance caused by long-term alcohol consumption or improper diet from the root cause of physical conditioning, and are prone to repeated symptoms.

[0008] Preferably, the functional composition includes a liver-protecting and strengthening composition, an intestinal regulation composition, a physical balance composition, and a flavor functional composition, and their parts by weight are 3 parts - 7 parts, 8 parts - 16 parts, 8 parts - 14 parts, and 1 part - 2 parts in sequence.

[0009] Preferably, the liver-protecting and strengthening composition includes Silybum marianum and Curcuma longa, and their weight ratio is 2 - 4:1 - 3. The Silybum marianum is an extract of Silybum marianum, and the silymarin content is ≥80%. The Curcuma longa is turmeric powder or curcumin extract with a curcumin content ≥95%. The intestinal regulation composition includes fructooligosaccharide and Hericium erinaceus, and their weight ratio is 5 - 10:3 - 6. The fructooligosaccharide is a mixture of fructans with a polymerization degree of 2 - 9. The Hericium erinaceus is Hericium erinaceus micropowder with a particle size ≤100 mesh and a polysaccharide content ≥30% or Hericium erinaceus polysaccharide extract.

[0010] Preferably, the physical balance composition includes Lycium barbarum and Cornus officinalis, and their weight ratio is 5 - 8:3 - 6. The Cornus officinalis is dry Cornus officinalis, an aqueous extract with an extraction rate ≥15% or Cornus officinalis micropowder with a particle size ≤100 mesh. The Lycium barbarum is the powder of dried ripe fruits of Lycium barbarum, and the particle size ≤80 mesh. The flavor functional composition is one of Mentha haplocalyx, Chrysanthemi flos, and Lonicerae japonicae flos.

[0011] A preparation method of a tea granule for clearing the liver and resolving dampness, which is applied to the above-mentioned tea granule for clearing the liver and resolving dampness, includes the following steps:

[0012] S1. Mix Hovenia dulcis, Puerariae flos, Poria cocos, Citrus reticulata, Perillae caulis, Gardeniae fructus, Prunella vulgaris, and Amomi fructus according to the parts by weight, crush and sieve to obtain materials, and sieve xylitol and L-malic acid respectively;

[0013] S2. Mix silybum marianum and turmeric according to the weight ratio to form a liver protection and strengthening composition, mix fructooligosaccharide and hericium erinaceus to form an intestinal regulation composition, mix wolfberry and corn silk to form a physical balance composition, and mix the liver protection and strengthening composition, intestinal regulation composition, physical balance composition, and flavor and function composition according to the parts by weight to form a functional composition;

[0014] S3. Add the materials to purified water, soak them, then heat to boiling and keep slightly boiling, filter to collect the first filtrate, then add purified water again, decoct and filter, combine with the first filtrate, centrifuge and take the supernatant to obtain a clarified extract;

[0015] S4. Concentrate the clarified extract to a relative density, preheat it, then perform spray drying, and then collect and screen it to obtain a traditional Chinese medicine extract powder;

[0016] S5. Put the sieved xylitol, L - malic acid, traditional Chinese medicine extract powder, and functional composition into a three - dimensional mixer for mixing to obtain a mixed dry powder, add hydroxypropyl methylcellulose to purified water to prepare a binder solution, put the mixed dry powder into a trough - type mixer, add the binder solution under stirring and continue stirring to make a soft material;

[0017] S6. Make the soft material into wet granules by a rocking granulator, spread the wet granules on a baking tray, dry them and then screen and size them to obtain the tea granules for clearing the liver and removing dampness.

[0018] Preferably, the mesh number of the crushing and screening in S1 is 40 meshes, the mesh number of the separate screening is 80 meshes, and the mixing in S2 is carried out by a three - dimensional mixer or a trough - type mixer.

[0019] Preferably, the addition amount of purified water added in S3 is 8 - 10 times the weight of the materials, the soaking time is 30 min, the temperature for keeping slightly boiling is 95 - 100 °C and the time is 30 min, the addition amount of purified water added again is 6 - 8 times the weight of the materials, the decocting time is 20 min, the centrifugation rate is 3000 r / min, and the centrifugation time is 10 min.

[0020] Preferably, the concentration temperature in S4 is 60 - 70 °C, the vacuum degree is - 0.06 MPa, the relative density is 1.15 - 1.2, the preheating temperature is 50 °C, the feed flow rate of the spray drying is 20 - 30 mL / min, the inlet air temperature is 175 - 185 °C, the outlet air temperature is 75 - 85 °C, and the mesh number of the screening is 80 meshes.

[0021] Preferably, the mixing rate in S5 is 30 r / min, the time is 20 min, the temperature of the purified water is 50° C., the amount of hydroxypropyl methylcellulose added is 0.2%-0.3% of the total mass, the concentration of the adhesive solution is 5%, the continuous stirring rate is 15-20 r / min, the time is 10 min, and the water content of the soft material is 18%-22%.

[0022] Preferably, the diameter of the wet particles in S6 is 2-4 mm, the drying temperature is 58-62° C., the wind speed is 0.5-1.0 m / s, the drying time is 4-6 h, the moisture content after drying is ≤5%, and the sieving and granulating is to pass through a 16-mesh sieve to remove fine powder and lumps.

[0023] The present invention provides a tea drink granule for clearing liver and removing dampness. It has the following beneficial effects:

[0024] 1. The present invention accelerates alcohol metabolism through Hovenia dulcis and Pueraria lobata flower to reduce the burden on the liver, Gardenia jasminoides and Prunella vulgaris clear the liver, gallbladder and triple burner dampness and heat, Silymarin and curcumin repair damaged liver cells and enhance the liver's detoxification ability, Amomum villosum, dried tangerine peel and Perilla stem promote qi and harmonize the stomach, relieve abdominal distension and nausea, Poria invigorates the spleen and aids transportation, Hovenia dulcis and Poria are diuretic and eliminate dampness, Poria, dried tangerine peel, Perilla stem and the like regulate the spleen and stomach, promote transportation and transformation functions, and expel dampness and heat from the body, Fructooligosaccharides and Hericium erinaceus regulate intestinal flora and reduce endotoxin production, Lycium barbarum and corn silk balance the physical constitution and improve the overall health level, thereby solving the problem that traditional tea granules cannot improve the imbalance of the internal environment caused by long-term drinking or improper diet from the root of physical conditioning, and symptoms are prone to recurrence.

[0025] 2. The present invention scientifically combines traditional alcohol-detoxifying herbs such as Hovenia dulcis and Pueraria lobata with modern liver-protecting ingredients such as Milk thistle and Curcuma longa to detoxify alcohol. Hovenia dulcis and Pueraria lobata accelerate alcohol metabolism and reduce liver burden. Silymarin and curcumin repair damaged liver cells and enhance liver detoxification ability. The synergistic effect of multiple ingredients realizes full-process protection from alcohol detoxification to liver protection, effectively alleviating the damage to the liver caused by drinking.

[0026] 3. The present invention uses Gardenia and Prunella Vulgaris to clear away heat and purge fire, Poria and Tangerine Peel to invigorate the spleen and eliminate dampness, Perilla stem and Amomum villosum to regulate qi and harmonize the middle, thereby improving the relief rate of damp-heat symptoms, improving symptoms such as oily face, bitter and dry mouth, short and red yellow urine, and sticky stools, improving the imbalance of the internal environment from the root of physical conditioning, and reducing the recurrence of symptoms.

[0027] 4. The present invention promotes the growth of beneficial intestinal bacteria, inhibits the reproduction of harmful bacteria, and relieves constipation symptoms through the synergistic effect of oligofructose and Hericium erinaceus. It not only improves the digestion and absorption function of the intestine, but also reduces the production of endotoxins, reduces the detoxification pressure of the liver, and realizes the healthy linkage between the intestine and the liver. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a process flow chart of a preparation method of a tea drink granule for clearing the liver and resolving dampness proposed by the present invention;

[0029] Figure 2 It is the detection result of the ADH content in the livers of mice in each group of the present invention;

[0030] Figure 3 It is the detection result of the MDA content in the livers of mice in each group of the present invention;

[0031] Figure 4 It is the detection result of the SOD content in the livers of mice in each group;

[0032] Figure 5 It is the detection result of the GSH content in the livers of mice in each group;

[0033] Figure 6 It is the detection result of the ALT content in the livers of mice in each group;

[0034] Figure 7 It is the detection result of the AST content in the livers of mice in each group;

[0035] Figure 8 It is the HE staining result of the liver tissue of model control group - 1 magnified by 200×;

[0036] Figure 9 It is the HE staining result of the liver tissue of model control group - 2 magnified by 200×;

[0037] Figure 10 It is the HE staining result of the liver tissue of administration group - 1 magnified by 200×;

[0038] Figure 11 It is the HE staining result of the liver tissue of administration group - 2 magnified by 200×. Detailed implementation manners

[0039] Next, the technical solutions of the present invention will be clearly and completely described in conjunction with the accompanying drawings of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0040] The embodiments of the present invention provide a tea drink granule for clearing the liver and resolving dampness, which comprises the following raw materials in parts by weight: 8 - 12 parts of Hovenia dulcis, 4 - 6 parts of Puerariae flos, 8 - 12 parts of Poria cocos, 5 - 8 parts of Pericarpium Citri Reticulatae, 5 - 8 parts of Caulis Perillae, 5 - 8 parts of Gardenia jasminoides Ellis, 5 - 8 parts of Spica Prunellae, 2 - 4 parts of Fructus Amomi, 50 - 60 parts of xylitol, 0.2 - 0.4 parts of L - malic acid, and 8 - 29 parts of a functional composition.

[0041] Specifically, by adding Hovenia dulcis, which is rich in various active ingredients, it can effectively decompose alcohol toxicity, enhance the liver's ability to metabolize alcohol, thereby reducing the damage of alcohol to the liver, achieving the effect of relieving hangover and protecting the liver, and providing protection for the liver of drinkers.

[0042] By adding Pueraria lobata, substances such as flavonoids contained in Pueraria lobata can promote the decomposition and excretion of alcohol, act synergistically with Hovenia dulcis, thereby accelerating the clearance of alcohol in the body, further strengthening the hangover effect, achieving the purpose of quickly sobering up, and helping drinkers relieve discomfort symptoms after drinking.

[0043] By adding Poria cocos, Poria cocos contains components such as Poria polysaccharide, can enhance the body's immunity, and at the same time has the effect of strengthening the spleen and promoting diuresis to eliminate dampness, thereby promoting the excretion of dampness in the body, regulating the function of the spleen and stomach, achieving the effect of improving the symptoms of spleen and stomach weakness and enhancing the body's resistance to damp pathogens, and has a good conditioning effect on people with damp-heat constitution.

[0044] By adding Citrus reticulata Blanco cv. Chachiensis Hort., it contains volatile oils, hesperidin and other components, and has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm, thereby improving symptoms such as abdominal distension and nausea caused by qi stagnation in the spleen and stomach, achieving the effect of regulating the qi movement of the spleen and stomach and enhancing the transportation and transformation function of the spleen and stomach, so that the tea granules can play a good conditioning role on the spleen and stomach while clearing the liver and resolving dampness.

[0045] By adding Perilla frutescens (L.) Britt. var. acuta (Thunb.) Kudo, Perilla frutescens (L.) Britt. var. acuta (Thunb.) Kudo is rich in volatile oils, etc., can promote qi movement and relieve fullness, thereby relieving discomfort such as stuffiness in the chest and epigastric distension, achieving the effect of smoothing qi movement and relieving qi stagnation symptoms, assisting components such as Citrus reticulata Blanco cv. Chachiensis Hort. to better condition the spleen and stomach, and promoting digestion and absorption.

[0046] By adding Gardenia jasminoides Ellis, components such as geniposide in Gardenia jasminoides Ellis have the effects of clearing heat and purging fire, cooling blood and detoxifying, thereby clearing away the damp-heat pathogen in the body, especially having a significant effect on clearing damp-heat in the liver, gallbladder and triple energizer, achieving the functions of clearing the liver and purging fire, promoting diuresis and detoxifying, and improving symptoms such as bitter taste in the mouth and yellow urine in people with damp-heat constitution.

[0047] By adding Prunella vulgaris L., it contains active ingredients such as prunellin, can clear the liver and purge fire, disperse stasis and reduce swelling, thereby helping to clear liver fire, relieve symptoms such as red and swollen eyes and dizziness caused by the flaring up of liver fire, achieving the effects of clearing the liver and improving eyesight, dispersing stasis and reducing swelling, and synergistically enhancing the effect of clearing the liver and resolving dampness with Gardenia jasminoides Ellis.

[0048] By adding Amomum villosum Lour., Amomum villosum Lour. is rich in volatile oils, has a fragrant smell, can promote digestion and relieve dampness, warm the spleen and stop diarrhea, thereby enhancing the transportation and transformation function of the spleen and stomach, promoting appetite, relieving symptoms such as stomachache and diarrhea caused by deficiency-cold of the spleen and stomach, achieving the effects of warming the spleen and strengthening the stomach, promoting digestion and relieving dampness and stopping diarrhea, and making the conditioning effect of the tea granules on people with spleen and stomach weakness more comprehensive.

[0049] Hovenia dulcis and Puerariae flos are often used to relieve alcohol intoxication. In the ranges of 8 - 12 parts and 4 - 6 parts in this tea - drink granule, it can not only ensure the effect of relieving alcohol and protecting the liver, but also avoid the adverse reactions caused by excessive dosage. Poria cocos is commonly used in a relatively large amount in the prescriptions for strengthening the spleen and promoting diuresis. 8 - 12 parts can ensure its full play of the effects of strengthening the spleen and promoting digestion and promoting diuresis in the tea - drink granule. Pericarpium Citri Reticulatae and Caulis Perillae regulate qi and harmonize the middle - jiao. The dosage of 5 - 8 parts conforms to the dosage range of such medicinal materials in the traditional Chinese medicine qi - regulating prescriptions and can effectively relieve symptoms such as abdominal distension and nausea. Gardenia jasminoides Ellis and Prunella vulgaris clear the liver and purge fire. The dosage of 5 - 8 parts can play the role of clearing heat and promoting diuresis while controlling its cold and bitter nature to avoid excessive damage to the spleen and stomach. Fructus Amomi can eliminate dampness and arouse the spleen. 2 - 4 parts can not only exert the medicinal effect, but also prevent excessive dryness and heat caused by excessive use due to its pungent, fragrant and warm nature.

[0050] By adding xylitol as a sweetener, which has the characteristics of high sweetness and low calories, it can improve the taste of the tea - drink granule, cover up the bitter taste of traditional Chinese medicine, and achieve the purpose of enhancing the palatability of the product, making it easier for consumers to accept the tea - drink granule.

[0051] By adding L - malic acid, L - malic acid has a unique sour taste and can adjust the taste of the tea - drink granule to make it moderately sour and sweet, thereby increasing the flavor of the product, achieving the function of further optimizing the taste, and enhancing the drinking experience of consumers.

[0052] Xylitol and L - malic acid as flavoring components, with the weight - part ranges of 50 - 60 parts and 0.2 - 0.4 parts, are to balance the taste of the tea - drink granule. Xylitol has a relatively high sweetness. Appropriate use can cover up the bitter taste of traditional Chinese medicine, and at the same time, it has low calories and is suitable for health - conscious consumers. L - malic acid provides a moderate sour taste. When paired with xylitol, it makes the tea - drink granule sour and sweet, enhances the palatability of the product, and ensures that consumers are more likely to accept it.

[0053] By adding the functional composition, it can further enhance the antioxidant and detoxification abilities of the liver, protect liver cells, regulate the balance of intestinal flora, promote intestinal health, help regulate the body functions, balance the physique, add a unique flavor, and also have certain effects such as clearing heat and improving eyesight, achieving multi - dimensional functional enhancement and further improving the health - care effect of the product.

[0054] Through the combination of various ingredients, Hovenia dulcis and Pueraria lobata accelerate alcohol metabolism and reduce the burden on the liver; Gardenia jasminoides and Prunella vulgaris clear liver and gallbladder and triple energizer dampness and heat; Silymarin and curcumin repair damaged liver cells and enhance the liver's detoxification ability; Amomum villosum, dried tangerine peel, and Perilla stem promote qi and relieve abdominal distension and nausea; Poria strengthens the spleen and aids transportation; Hovenia dulcis and Poria promote diuresis and eliminate dampness; Poria, dried tangerine peel, and Perilla stem regulate the spleen and stomach, promote transportation and transformation functions, and expel dampness and heat from the body; Oligofructose and Hericium erinaceus regulate intestinal flora and reduce endotoxin production; Lycium barbarum and corn silk balance the physical constitution and improve the overall health level. Xylitol and L-malic acid improve the taste without affecting the efficacy. It realizes a systematic regulation from alcohol detoxification and liver protection, clearing heat and dampness, regulating the spleen and stomach to balancing the physical constitution, solving the problem that traditional tea granules cannot improve the imbalance of the internal environment caused by long-term drinking or improper diet from the root of physical conditioning, and symptoms are prone to recurrence.

[0055] The functional composition includes a liver protection and strengthening composition, an intestinal regulation composition, a physical balance composition, and a flavor functional composition, and the weight portions thereof are 3-7 parts, 8-16 parts, 8-14 parts, and 1-2 parts, respectively. The liver protection and strengthening composition includes milk thistle and turmeric, and the weight ratio thereof is 2-4:1-3. The milk thistle is a milk thistle extract, wherein the silymarin content is ≥80%, and the turmeric is a turmeric powder or a curcumin extract having a curcumin content of ≥95%. The intestinal regulation composition includes oligofructose and hericium erinaceus, and the weight ratio thereof is 5-10:3-6. The oligofructose is a fructan mixture having a polymerization degree of 2-9, and the hericium erinaceus is a hericium erinaceus micropowder or a hericium erinaceus polysaccharide extract having a particle size of ≤100 mesh and a polysaccharide content of ≥30%. The body constitution balancing composition comprises wolfberry and corn silk in a weight ratio of 5-8:3-6. The corn silk is dry corn silk, a water extract with an extraction rate of ≥15% or corn silk micro powder with a particle size of ≤100 meshes. The wolfberry is a dried mature fruit powder of wolfberry with a particle size of ≤80 meshes. The flavor functional composition is one of mint, chrysanthemum and honeysuckle.

[0056] Specifically, the liver protection and strengthening composition is set to 3-7 parts by weight, and contains milk thistle and turmeric in a weight ratio of 2-4:1-3. Milk thistle uses milk thistle extract, and the silymarin content is ≥80%, and turmeric is turmeric powder or curcumin extract with a curcumin content of ≥95%. Silymarin has a strong antioxidant and liver cell protection effect, can stabilize the liver cell membrane, and promote the repair and regeneration of liver cells. Curcumin has anti-inflammatory, antioxidant and choleretic effects. The two work synergistically to enhance the liver's metabolism and detoxification ability of harmful substances such as alcohol. The weight range of 3-7 parts can not only ensure that sufficient liver protection active ingredients are provided in the tea granules, but also will not lead to excessive costs or affect the balance of the overall formula due to excessive addition.

[0057] The intestinal regulation composition is 8 to 16 parts by weight and consists of fructooligosaccharide and Hericium erinaceus, with a weight ratio of 5 - 10:3 - 6. As a prebiotic, fructooligosaccharide has a degree of polymerization between 2 and 9. It can selectively promote the growth and reproduction of beneficial intestinal bacteria (such as Bifidobacterium), inhibit the growth of harmful bacteria, and improve the intestinal microecological environment. Hericium erinaceus is Hericium erinaceus micropowder with a particle size ≤ 100 mesh and a polysaccharide content ≥ 30% or Hericium erinaceus polysaccharide extract. Hericium erinaceus polysaccharide has the effects of protecting the gastric mucosa and enhancing intestinal immunity. The weight range of 8 - 16 parts by weight is considered. Since fructooligosaccharide mainly regulates the intestinal flora, a certain amount is required to ensure effective regulation of the intestinal microecology. Hericium erinaceus focuses on protecting the gastric mucosa and enhancing intestinal immunity. Intestinal problems are relatively common in people with damp-heat constitution and those who drink alcohol, and sufficient doses are needed to play a role in regulating intestinal function, promoting digestion and absorption, and relieving symptoms such as sticky stools.

[0058] The physical balance composition is 8 to 14 parts by weight and contains wolfberry and corn silk, with a weight ratio of 5 - 8:3 - 6. The corn silk is an aqueous extract with a dry corn silk extraction rate ≥ 15% or corn silk micropowder with a particle size ≤ 100 mesh. The wolfberry is the powder of the dried ripe fruit of Lycium barbarum and has a particle size ≤ 80 mesh. Wolfberry is rich in nutrients such as wolfberry polysaccharide and carotenoids, and has the effects of tonifying the liver and kidney, and improving eyesight. Corn silk has the effects of diuresis and detumescence, and clearing heat and promoting bile flow. The combination of the two helps to regulate the internal environment of the human body and balance the physique. It enables the tonifying effect of wolfberry and the heat-clearing and diuretic effect of corn silk to coordinate with each other, so that the effects of both can be better exerted, avoiding the dryness and heat caused by excessive wolfberry and ensuring the heat-clearing and dampness-draining effect of corn silk. The weight range of 8 - 14 parts by weight is to provide sufficient nutritional components and regulating substances in the tea granules, improve the damp-heat constitution, enhance the body's resistance, and maintain the balance of yin and yang in the body.

[0059] The flavor and function composition is 1 to 2 parts by weight and is one of mint, chrysanthemum, and honeysuckle. These three ingredients all have unique flavors and certain medicinal values. Mint can bring a cool taste and relieve symptoms such as bitter mouth and bad breath; chrysanthemum has the effects of clearing the liver and improving eyesight, and clearing heat and detoxifying, and can assist in improving symptoms such as dry eyes caused by damp-heat; honeysuckle also has the effects of clearing heat and detoxifying, and dispersing wind and heat. Selecting one of them as the flavor and function composition and setting the weight part as 1 - 2 parts, on the one hand, is to add a unique flavor to the tea granules and enhance the taste and aroma of the product; on the other hand, their medicinal values can also assist the overall formula to play the role of clearing the liver and resolving dampness. Since it mainly plays a role in flavoring and assisting efficacy, a large amount does not need to be added. 1 - 2 parts can not only meet the flavoring requirements but also will not affect the efficacy of other ingredients and the stability of the overall formula.

[0060] Please refer to the appendix Figure 1A method for preparing tea granules for clearing liver and removing dampness, which is applied to the above-mentioned tea granules for clearing liver and removing dampness, comprises the following steps:

[0061] S1. Mix Hovenia dulcis, pueraria flower, Poria cocos, dried orange peel, perilla stem, gardenia, selfheal and Amomum villosum according to weight, crush and sieve to obtain materials, and sieve xylitol and L-malic acid respectively; the mesh number of crushing and sieving in S1 is 40 mesh, and the mesh number of sieving is 80 mesh.

[0062] Specifically, Chinese medicinal materials such as Hovenia dulcis and Puerariae lobata are mixed according to weight, crushed in a pulverizer, and then sieved through a 40-mesh sieve. If the mesh number is too small (such as 20 mesh), the medicinal material particles are large, and the effective ingredients are difficult to fully dissolve during the subsequent water decoction process, which will reduce the extraction efficiency; if the mesh number is too large (such as 80 mesh), the medicinal material powder is too fine, which will increase the crushing cost and energy consumption on the one hand, and easily cause the solution to be too viscous during the extraction process on the other hand, increase the difficulty of filtration, and even clog the equipment pipeline. The 40-mesh sieve can not only ensure that the medicinal material has a suitable specific surface area, which is conducive to the dissolution of the effective ingredients, but also take into account production efficiency and cost.

[0063] Xylitol and L-malic acid are sieved through 80 mesh sieves respectively. This is because the particle size of xylitol and L-malic acid as flavoring agents will affect the dispersion uniformity and taste in tea particles. The 80 mesh sieve can form finer particles of the two, which can be mixed more evenly with other ingredients in the subsequent mixing process to avoid local oversweetness or oversourness, ensuring the consistency of the taste of the tea particles. At the same time, the particles with this mesh size are also more suitable in terms of dissolution speed, which is convenient for the rapid release of flavoring effects when drinking.

[0064] By crushing the Chinese medicinal materials and passing them through a 40-mesh sieve, the specific surface area of ​​the medicinal materials is increased, which is beneficial to the dissolution of the effective ingredients during the subsequent extraction; xylitol and L-malic acid are passed through an 80-mesh sieve to ensure that their particles are fine, which facilitates uniform dispersion in the subsequent mixing process, laying the foundation for improving the taste and flavor of the tea particles.

[0065] S2. Mix milk thistle and turmeric according to weight ratio to form a liver protection and strengthening composition, mix oligofructose and hericium erinaceus to form an intestinal regulating composition, mix wolfberry and corn silk to form a physical balance composition, and mix the liver protection and strengthening composition, the intestinal regulating composition, the physical balance composition, and the flavor functional composition according to weight ratio to form a functional composition; the mixing in S2 adopts a three-dimensional mixer or a trough mixer.

[0066] Specifically, different mixing equipment is selected according to the characteristics of the ingredients. For dry powder ingredients such as silybum marianum, turmeric, wolfberry, and corn silk, due to their good fluidity, a three-dimensional mixer is used for mixing. The three-dimensional mixer can make the materials flip and move in multiple directions in space through a unique movement trajectory, thus achieving a highly uniform mixing of the materials, and the mixing uniformity can reach over 99%. For fructooligosaccharides and hericium erinaceus, since fructooligosaccharides have a certain hygroscopicity and the micropowder of hericium erinaceus also has a certain viscosity, agglomeration is likely to occur when the two are mixed. Therefore, a trough mixer is used. The trough mixer can strongly shear and stir the materials through the stirring action of the paddle blades, effectively breaking the agglomeration of the materials and making the fructooligosaccharides and hericium erinaceus fully and evenly mixed. At the same time, the trough mixer can also be set with a heating function as needed, and the temperature can be appropriately increased (such as 30 - 40 °C) when necessary to reduce the viscosity of fructooligosaccharides and further improve the mixing effect. When mixing each functional composition according to parts by weight to form the total functional composition, a three-dimensional mixer can also be used to ensure the uniform distribution of each functional module and guarantee the consistency and stability of the efficacy of the tea drink particles.

[0067] Select a three-dimensional mixer or a trough mixer for mixing according to the characteristics of each ingredient, so that the internal ingredients of the functional compositions such as liver protection enhancement and intestinal regulation are fully mixed. Then mix each functional composition to ensure the uniform distribution of the functional ingredients in the tea drink particles, thereby ensuring the consistency and stability of the efficacy of the tea drink particles.

[0068] S3. Add the materials to purified water, soak them, then heat to boiling and keep slightly boiling, filter to collect the first filtrate. Then add purified water again, decoct and filter, combine with the first filtrate, and take the supernatant after centrifugation to obtain a clarified extract; the added amount of purified water in S3 is 8 - 10 times the weight of the materials, the soaking time is 30 min, the temperature for keeping slightly boiling is 95 - 100 °C, and the time is 30 min. The added amount of purified water added again is 6 - 8 times the weight of the materials, the decocting time is 20 min, and the centrifugation rate is 3000 r / min, and the centrifugation time is 10 min.

[0069] Specifically, add purified water 8 - 10 times the weight of the materials for the first time for soaking, and set the soaking time to 30 min. The purpose of soaking is to make the medicinal material cells fully absorb water and expand, which is beneficial to the dissolution of the active ingredients during subsequent decoction. If the amount of added water is too small (less than 8 times), the medicinal materials cannot be fully wetted and the active ingredients are difficult to dissolve; if the amount of added water is too much (more than 10 times), it will increase the energy consumption and time cost of the subsequent concentration process. The soaking time of 30 min can not only make the medicinal materials achieve a good wetting effect, but also prevent the growth of microorganisms and the enzymatic loss of active ingredients due to too long soaking time.

[0070] After heating and boiling, keep the temperature at 95-100℃ for 30 minutes for the first decoction. Within this temperature range, the water can be kept in a boiling state, accelerate the movement of molecules, and promote the dissolution of effective ingredients from the medicinal material cells into the solution, while avoiding excessive temperature (such as exceeding 100℃ too much) that causes some heat-sensitive components (such as certain volatile components and polysaccharide components that are not resistant to high temperatures) to decompose and destroy. After many experiments, it has been verified that the 30-minute decoction time can fully dissolve most of the effective ingredients. If the decoction time is extended, the amount of effective ingredients dissolved will not increase significantly, but it will increase energy consumption and production costs.

[0071] Add 6-8 times the weight of the material in purified water for the second time and boil for 20 minutes. The second decoction is mainly to extract the remaining active ingredients in the medicinal materials. The amount of water added is reduced compared to the first time because after the first decoction, most of the soluble active ingredients in the medicinal materials have entered the first filtrate. Reducing the amount of water added can increase the concentration of active ingredients in the second extract and reduce the cost of subsequent concentration. The 20-minute decoction time is enough to extract the remaining active ingredients, and further extending the time will have limited effect on the extraction rate of active ingredients.

[0072] After the two filtrates are combined, centrifuge at 3000r / min for 10 minutes to obtain the supernatant. This centrifugal speed and time are set to effectively separate solid impurities in the filtrate (such as incompletely crushed medicinal powder, precipitation produced during the decoction process, etc.). If the centrifugal speed is too low (such as 2000r / min), it is difficult to separate the fine impurity particles from the solution, resulting in turbidity of the extract; if the centrifugal speed is too high (such as 5000r / min), it may destroy the structure of some macromolecular effective ingredients (such as polysaccharides, proteins, etc.), affecting product quality. The centrifugal time of 10 minutes can ensure that the impurities are fully settled and a clear extract is obtained, providing high-quality raw materials for subsequent concentration and drying processes.

[0073] Through two decoctions with different water amounts, combined with appropriate soaking, decoction time and temperature, the effective ingredients in the Chinese medicinal materials can be fully extracted; the subsequent centrifugation operation is centrifuged at a rate of 3000r / min for 10min to effectively separate impurities in the extract and obtain a clarified extract, providing high-purity raw materials for subsequent processes.

[0074] S4, concentrating the clarified extract to a relative density, preheating, spray drying, and then collecting and sieving to obtain a Chinese medicine extract powder; the concentration temperature in S4 is 60-70°C, the vacuum degree is -0.06MPa, the relative density is 1.15-1.2, the preheating temperature is 50°C, the feed flow rate of spray drying is 20-30mL / min, the inlet temperature is 175-185°C, the outlet temperature is 75-85°C, and the mesh number of the sieve is 80 mesh.

[0075] Specifically, the clarified extract is concentrated to a relative density of 1.15-1.2 at 60-70°C and a vacuum degree of -0.06MPa. Low-temperature vacuum concentration is used because most of the active ingredients in the extract are heat-sensitive substances, such as curcumin, silymarin, etc., and high temperature will cause them to decompose or lose their activity. The temperature range of 60-70°C can not only ensure the concentration efficiency, but also effectively protect the active ingredients. The vacuum degree is set to -0.06MPa, which can reduce the boiling point of the solution and further achieve rapid concentration at a lower temperature. The relative density is controlled at 1.15-1.2, at which time the concentrate has a suitable viscosity. If the relative density is too low (such as less than 1.15), the concentrate is too thin, which will lead to excessive feed volume during spray drying, reduced drying efficiency, and difficult particle formation; if the relative density is too high (such as more than 1.2), the concentrate is too viscous, the fluidity becomes poor, and it is difficult to be evenly atomized through the nozzle of the spray dryer, which is easy to clog the nozzle and affect production continuity.

[0076] The concentrate is preheated to 50°C to make the temperature of the concentrate uniform, reduce its viscosity, improve fluidity, and facilitate smooth atomization through the nozzle during the spray drying process. If it is not preheated or the preheating temperature is too low, the viscosity of the concentrate is high, the atomization effect is poor, and large droplets will be formed, resulting in uneven particle size after drying; if the preheating temperature is too high (such as over 60°C), the heat-sensitive components in the concentrate may begin to degrade, affecting product quality.

[0077] During spray drying, the feed flow rate is set to 20-30mL / min, the inlet air temperature is 175-185℃, and the outlet air temperature is 75-85℃. When the feed flow rate is within this range, it can ensure that the atomized droplets have enough time to fully contact with the hot air in the drying tower to achieve rapid drying. If the feed flow rate is too fast (such as exceeding 30mL / min), the droplets cannot be dried in time, which will cause the particles to stick and agglomerate; if the feed flow rate is too slow (such as less than 20mL / min), the production efficiency will be greatly reduced. The inlet air temperature of 175-185℃ provides sufficient heat for the hot air to quickly evaporate the water on the surface of the atomized droplets to form dry particles; the outlet air temperature of 75-85℃ ensures that the particles are completely dry when they leave the drying tower, and the particles will not change color or the effective ingredients will not decompose due to excessive temperature. The dried Chinese medicine extract powder is sieved through an 80-mesh sieve to remove large particles and lumps that may be produced during the drying process, to ensure the uniformity of the powder particle size, to facilitate subsequent mixing with other ingredients, and to meet the requirements of tea granules for raw material particle size, which is beneficial to the dissolution rate when taken with water.

[0078] Low-temperature vacuum concentration, appropriate preheating temperature, and precise spray drying parameters are used to protect the heat-sensitive active ingredients in the extract while efficiently converting the concentrate into Chinese medicine extract powder with uniform particle size. The powder quality is further guaranteed by passing through an 80-mesh sieve, which is beneficial for subsequent mixing and granulation.

[0079] S5. Put the sieved xylitol, L - malic acid, traditional Chinese medicine extract powder, and functional composition into a three - dimensional mixer for mixing to obtain a mixed dry powder. Add hydroxypropyl methylcellulose to purified water to prepare a binder solution. Put the mixed dry powder into a trough - type mixer, add the binder solution under stirring and continue stirring to make a soft material; the mixing rate in S5 is 30 r / min, the time is 20 min, the temperature of the purified water is 50 °C, the addition amount of hydroxypropyl methylcellulose is 0.2% - 0.3% of the total mass, the concentration of the binder solution is 5%, the continuous stirring rate is 15 - 20 r / min, the time is 10 min, and the water content of the soft material is 18% - 22%.

[0080] Specifically, put the sieved xylitol, L - malic acid, traditional Chinese medicine extract powder, and functional composition into a three - dimensional mixer and mix at a rate of 30 r / min for 20 min. This mixing rate and time can make each component fully flip and mix in three - dimensional space to ensure the mixing uniformity. The rate of 30 r / min can not only ensure that the materials have sufficient movement intensity for full mixing but also prevent the materials from being strongly impacted and rubbed in the mixer due to too fast a rate, avoiding damage to heat - sensitive components (such as some active components in the functional composition). The mixing time of 20 min has been verified by experiments, which can make each component mixed evenly. Further extending the mixing time has no obvious improvement in the uniformity, but will increase energy consumption and production time.

[0081] Add hydroxypropyl methylcellulose accounting for 0.2% - 0.3% of the total mass to 50 °C purified water to prepare a binder solution with a concentration of 5%.

[0082] Select 50 °C purified water because at this temperature, the dissolution rate of hydroxypropyl methylcellulose is relatively fast and a uniform and stable solution can be formed. If the water temperature is too low (such as 20 °C), the dissolution of hydroxypropyl methylcellulose is slow and even lumps may form, making it difficult to dissolve completely; if the water temperature is too high (such as 80 °C), the molecular structure of hydroxypropyl methylcellulose may be damaged, affecting its viscosity. If the addition amount of hydroxypropyl methylcellulose is too low or the solution concentration is too low, the binder viscosity is insufficient, and the materials cannot be effectively agglomerated into granules, resulting in a large amount of loose powder during the granulation process and a low granule forming rate; if the addition amount is too high or the solution concentration is too high, the soft material has too high a viscosity, which will cause difficulties in granulation, the granules are easy to stick, and even block the sieve of the granulator, and the formed granules are too hard, which is not conducive to dissolution during taking with water.

[0083] Put the mixed dry powder into a trough mixer, add the binder solution at a stirring rate of 15 - 20 r / min and continuously stir for 10 min to make a soft material with a water content of 18% - 22%. The stirring rate of 15 - 20 r / min can ensure that the binder solution is in full contact with the mixed dry powder and is evenly mixed, avoiding the situation of too high or too low local viscosity. The stirring time of 10 min can ensure that the binder is evenly distributed in the dry powder to form a soft material with uniform texture. The water content of the soft material is controlled at 18% - 22%. If the water content is too low (such as less than 18%), the soft material is too dry and difficult to pass through the sieve during granulation, and it is difficult to form particles. Moreover, the formed particles have a rough surface and are easy to break. If the water content is too high (such as more than 22%), the soft material is too wet and has too high viscosity, which will cause the particles to stick to each other during granulation and even make granulation impossible. The appropriate water content can ensure that the soft material has good plasticity and fluidity, facilitating the granulation operation, and at the same time making the formed particles have appropriate hardness and density.

[0084] Make each component fully mixed and uniform through a three-dimensional mixer, and then use a hydroxypropyl methylcellulose binder solution with a specific concentration and temperature to make a soft material with an appropriate water content in a trough mixer, providing a material with good plasticity and formability for subsequent granulation to ensure the stable quality of the particles.

[0085] S6. Make the soft material into wet granules through a rocking granulator, spread the wet granules evenly on a baking tray, dry them, and then screen and size them to obtain the tea granules for clearing the liver and removing dampness. In S6, the diameter of the wet granules is 2 - 4 mm, the drying temperature is 58 - 62 °C, the wind speed is 0.5 - 1.0 m / s, the drying time is 4 - 6 h, the water content after drying is ≤5%, and screening and sizing is to pass through a 16 - mesh sieve to remove fine powder and lumps.

[0086] Specifically, use a rocking granulator to make the soft material into wet granules with a diameter of 2 - 4 mm. The particle size of 2 - 4 mm is determined by comprehensively considering the convenience of taking the tea granules and the production efficiency. If the particle size is too small (such as less than 2 mm), the particles are easy to fly during taking, causing waste, and during the drying process, the fine particles are easy to be lost due to the action of wind. If the particle size is too large (such as more than 4 mm), the dissolution rate of the particles in water is slow, affecting the drinking experience, and at the same time, the too large particles are also easy to break during packaging and transportation. The rocking granulator extrudes the soft material into particles through the swing of the sieve, and the granulation process is gentle, with less damage to the active ingredients in the soft material.

[0087] Spread the wet particles on a baking tray and dry them for 4-6 hours at 58-62℃ and wind speed of 0.5-1.0m / s, so that the moisture content of the particles after drying is ≤5%. The drying temperature of 58-62℃ is selected because this temperature range can not only ensure the rapid evaporation of moisture, but also avoid the hardening of the particle surface and the inability to discharge the internal moisture due to excessive temperature, forming a "false drying" phenomenon, and at the same time protect the heat-sensitive components in the particles from being destroyed. The wind speed of 0.5-1.0m / s can take away the evaporated moisture in time and accelerate the drying process. If the wind speed is too low (such as less than 0.5m / s), the moisture evaporates slowly, the drying time is prolonged, and the particles are prone to mold and deterioration due to being in a humid environment for a long time; if the wind speed is too high (such as more than 1.0m / s), the moisture on the surface of the particles will evaporate quickly, forming a hard shell, which will hinder the internal moisture from continuing to evaporate, resulting in uneven drying. The 4-6h drying time has been verified by experiments and can reduce the moisture content of the particles to ≤5%, ensuring that the particles are not easy to absorb moisture and deteriorate during storage, thus ensuring product quality and shelf life.

[0088] The dried particles are sieved through a 16-mesh sieve to remove fine powder and agglomerates. The aperture size of the 16-mesh sieve (1.18mm) can effectively separate fine powder and agglomerated particles that do not meet the particle size requirements, making the particle size of the final product uniform. Too much fine powder will affect the appearance of the tea particles and the taste when brewing, and agglomerated particles will affect packaging and use. By sieving and sieving the particles, the quality and stability of the product can be improved to meet consumers' requirements for product quality.

[0089] Wet granules with suitable particle size are prepared using an oscillating granulator. The drying temperature, wind speed and time are precisely controlled to make the granules reach the ideal moisture content. Finally, they are sieved through a 16-mesh sieve to remove fine powder and lumps, thus obtaining the finished liver-clearing and dehumidifying tea granules with uniform particle size and excellent quality, ensuring the product's brewing performance and appearance quality.

[0090] The following is further introduced in conjunction with specific embodiments:

[0091] Embodiment 1:

[0092] A tea granule for clearing liver and removing dampness comprises the following raw materials in parts by weight: 12 parts of Hovenia dulcis, 6 parts of Pueraria lobata flower, 12 parts of Poria cocos, 8 parts of dried tangerine peel, 8 parts of Perilla stem, 8 parts of Gardenia jasminoides, 8 parts of Prunella vulgaris, 4 parts of Amomum villosum, 60 parts of xylitol, 0.4 parts of L-malic acid, and 29 parts of a functional composition.

[0093] The functional composition includes a liver protection and strengthening composition, an intestinal regulation composition, a physical balance composition, and a flavor functional composition, and the weight portions thereof are 5 parts, 12 parts, 10 parts, and 2 parts, respectively.

[0094] The liver-protecting and strengthening composition includes silybum marianum and turmeric, with a weight ratio of 3:2. The silybum marianum is silybum marianum extract, and the silybin content is ≥80%. The turmeric is turmeric powder or turmeric extract with a curcumin content of ≥95%. The intestinal regulation composition includes fructooligosaccharides and hericium erinaceus, with a weight ratio of 7.5:4.5. The fructooligosaccharides is a mixture of fructans with a degree of polymerization of 5.5, and the hericium erinaceus is hericium erinaceus micropowder with a particle size ≤100 mesh and a polysaccharide content of ≥30% or hericium erinaceus polysaccharide extract.

[0095] The physical balance composition includes wolfberry fruit and corn silk, with a weight ratio of 6.5:3.5. The corn silk is dried corn silk, an aqueous extract with an extraction rate of ≥15% or corn silk micropowder with a particle size ≤100 mesh. The wolfberry fruit is the powder of dried ripe wolfberry fruit, and the particle size is ≤80 mesh. The flavor and function composition is mint.

[0096] A preparation method of a tea drink granule for clearing the liver and removing dampness is applied to the above-mentioned tea drink granule for clearing the liver and removing dampness, and includes the following steps:

[0097] S1. Mixhovenia dulcis, flos puerariae, poria cocos, pericarpium citri reticulatae, perilla stem, gardenia jasminoides, prunella vulgaris, and fructus amomi according to parts by weight, crush and sieve to obtain materials, and sieve xylitol and L-malic acid respectively;

[0098] S2. Mix silybum marianum and turmeric according to a weight ratio to form a liver-protecting and strengthening composition, mix fructooligosaccharides and hericium erinaceus to form an intestinal regulation composition, mix wolfberry fruit and corn silk to form a physical balance composition, and mix the liver-protecting and strengthening composition, intestinal regulation composition, physical balance composition, and flavor and function composition according to parts by weight to form a functional composition;

[0099] S3. Add the materials to purified water, soak, heat to boiling and keep slightly boiling, filter to collect the first filtrate, then add purified water again, decoct and filter, combine with the first filtrate, centrifuge and take the supernatant to obtain a clarified extract;

[0100] S4. Concentrate the clarified extract to a relative density, preheat, perform spray drying, then collect and sieve to obtain a traditional Chinese medicine extract powder;

[0101] S5. Put the sieved xylitol, L-malic acid, traditional Chinese medicine extract powder, and functional composition into a three-dimensional mixer for mixing to obtain a mixed dry powder. Add hydroxypropyl methylcellulose to purified water to prepare a binder solution. Put the mixed dry powder into a trough mixer, add the binder solution under stirring and continue stirring to make a soft material;

[0102] S6. Make the soft material into wet granules by a swing granulator, spread the wet granules on a baking tray, dry and sieve and size to obtain the tea drink granule for clearing the liver and removing dampness.

[0103] The mesh number for sieving after crushing in S1 is 40 mesh, and the mesh number for separate sieving is 80 mesh. In S2, three-dimensional mixer or trough mixer is used for mixing.

[0104] In S3, the added amount of purified water is 9 times the weight of the material, the soaking time is 30 min, the temperature for maintaining slight boiling is 100 °C and the time is 30 min. The added amount of purified water added again is 7 times the weight of the material, the decocting time is 20 min, the centrifugation rate is 3000 r / min, and the centrifugation time is 10 min.

[0105] In S4, the concentration temperature is 65 °C, the vacuum degree is -0.06 MPa, the relative density is 1.175, the preheating temperature is 50 °C, the feeding flow rate for spray drying is 25 mL / min, the inlet air temperature is 180 °C, the outlet air temperature is 80 °C, and the mesh number for sieving is 80 mesh.

[0106] In S5, the mixing rate is 30 r / min and the time is 20 min. The temperature of purified water is 50 °C, the added amount of hydroxypropyl methylcellulose is 0.25% of the total mass, the concentration of the binder solution is 5%, the continuous stirring rate is 18 r / min and the time is 10 min. The water content of the soft material is 20%.

[0107] In S6, the diameter of the wet granules is 3 mm, the drying temperature is 60 °C, the wind speed is 0.75 m / s, the drying time is 5 h, the moisture content after drying is ≤5%, and sieving and sizing are carried out through a 16-mesh sieve to remove fine powder and lumps.

[0108] Example 2:

[0109] The difference between this example and the above Example 1 is as follows:

[0110] A kind of tea drink granules for clearing the liver and resolving dampness, comprising the following raw materials in parts by weight: 8 parts of Hovenia dulcis, 4 parts of Puerariae flos, 8 parts of Poria cocos, 5 parts of Citri reticulatae pericarpium, 5 parts of Perillae caulis, 5 parts of Gardeniae fructus, 5 parts of Prunella vulgaris, 2 parts of Amomi fructus, 50 parts of xylitol, 0.2 part of L-malic acid, 8 parts of functional composition.

[0111] The functional composition includes a liver protection strengthening composition, an intestinal regulation composition, a physical balance composition, and a flavor functional composition, and their parts by weight are 1.38 parts, 3.31 parts, 2.76 parts, and 0.55 part in sequence.

[0112] The liver-protecting and strengthening composition includes silybum marianum and turmeric, with a weight ratio of 3:2. The silybum marianum is silybum marianum extract, in which the silymarin content is ≥80%, and the turmeric is turmeric powder or turmeric extract with a curcumin content of ≥95%. The intestinal tract regulating composition includes fructooligosaccharide and hericium erinaceus, with a weight ratio of 7.5:4.5. The fructooligosaccharide is a mixture of fructans with a degree of polymerization of 5.5, and the hericium erinaceus is hericium erinaceus micropowder with a particle size ≤100 mesh and a polysaccharide content of ≥30% or hericium erinaceus polysaccharide extract.

[0113] The constitution-balancing composition includes wolfberry fruit and corn silk, with a weight ratio of 6.5:3.5. The corn silk is dried corn silk, an aqueous extract with an extraction rate of ≥15% or corn silk micropowder with a particle size ≤100 mesh, and the wolfberry fruit is powder of dried mature wolfberry fruits, with a particle size ≤80 mesh. The flavor and functional composition is chrysanthemum.

[0114] Example 3:

[0115] The difference between this example and Example 1 above is that:

[0116] A kind of tea granules for clearing the liver and removing dampness includes the following raw materials in parts by weight: 10 parts ofhovenia dulcis, 5 parts of flos puerariae lobatae, 10 parts of poria cocos, 6.5 parts of pericarpium citri reticulatae, 6.5 parts of caulis perillae, 6.5 parts of fructus gardeniae, 6.5 parts of spica prunellae, 3 parts of fructus amomi, 55 parts of xylitol, 0.3 part of L-malic acid, and 18.5 parts of functional composition.

[0117] The functional composition includes a liver-protecting and strengthening composition, an intestinal tract regulating composition, a constitution-balancing composition, and a flavor and functional composition, with parts by weight being 3.2 parts, 7.66 parts, 6.38 parts, and 1.27 parts in sequence.

[0118] The liver-protecting and strengthening composition includes silybum marianum and turmeric, with a weight ratio of 3:2. The silybum marianum is silybum marianum extract, in which the silymarin content is ≥80%, and the turmeric is turmeric powder or turmeric extract with a curcumin content of ≥95%. The intestinal tract regulating composition includes fructooligosaccharide and hericium erinaceus, with a weight ratio of 7.5:4.5. The fructooligosaccharide is a mixture of fructans with a degree of polymerization of 5.5, and the hericium erinaceus is hericium erinaceus micropowder with a particle size ≤100 mesh and a polysaccharide content of ≥30% or hericium erinaceus polysaccharide extract.

[0119] The constitution-balancing composition includes wolfberry fruit and corn silk, with a weight ratio of 6.5:3.5. The corn silk is dried corn silk, an aqueous extract with an extraction rate of ≥15% or corn silk micropowder with a particle size ≤100 mesh, and the wolfberry fruit is powder of dried mature wolfberry fruits, with a particle size ≤80 mesh. The flavor and functional composition is honeysuckle.

[0120] Table 1:

[0121]

[0122] The comparison values in the above table are for traditional tea drink granules. As can be seen from Table 1, different contents of Hovenia dulcis, Puerariae flos, Poria cocos, Citri reticulatae pericarpium, Perillae caulis, Gardeniae fructus, Prunellae vulgaris spica, Amomi fructus, Xylitol, L-Malic acid, and functional compositions can affect the blood alcohol concentration decline rate, hepatocyte survival rate, damp-heat symptom remission rate, constipation remission rate, and intestinal flora diversity index within 1 hour after drinking of the tea drink granules. Accelerating alcohol metabolism can reduce the risk of liver damage caused by alcohol. A high hepatocyte survival rate ensures the normal function of the liver. The effective remission of damp-heat symptoms and constipation, and the improvement of the intestinal flora diversity index on the original basis improve the spleen and stomach transportation function from the perspective of internal environment regulation, correct the damp-heat constitution, and thus affect the comprehensive conditioning effect of the tea drink granules, achieving multi-dimensional synergistic improvement from anti-alcoholism and hangover, liver protection to overall physical conditioning, and solving the problem that traditional tea drink granules cannot improve the internal environment imbalance caused by long-term alcohol consumption or improper diet from the root cause of physical conditioning, and are prone to recurrence of symptoms.

[0123] Example 4:

[0124] Study on the Anti-Alcoholism Effect of Tea Drink Granules for Clearing the Liver and Resolving Dampness

[0125] By establishing a mouse drunkenness model, the anti-alcoholism effect of the developed tea drink granules was verified, and the hangover effect of the tea drink granules on mice was explored, and the liver protection effect of the tea drink granules was detected.

[0126] Drug Information

[0127] Name: Tea Drink Granules for Clearing the Liver and Resolving Dampness

[0128] Appearance: Orange powder

[0129] Storage Conditions: Room temperature

[0130] Preparation Method: Weigh the required amount of tea drink granules and add an appropriate amount of distilled water to dilute to the required volume to obtain the tea drink.

[0131] Preparation Frequency: Prepare as needed

[0132] Temporary Storage Conditions after Preparation: Normal temperature

[0133] Experimental Animals

[0134] Strain, Species: C57BL / 6J mice

[0135] Grade: SPF level

[0136] Quarantine Adaptation Period: 7 days, observing the external physical signs of the animals.

[0137] Use an oil-based pen for tail marking. The cage card indicates information such as the test code, cage number, animal number, animal gender, test stage, and project leader, and is hung on the front of the breeding cage. The color of the cage card is white.

[0138] Animal model establishment

[0139] The results of the preliminary experiment for model establishment are as follows. Hongqidian (Red Star) Erguotou (Fen flavor liquor, 56% vol) purchased from the supermarket was selected for the mouse drunkenness experiment. To establish a safe and stable acute drunkenness model, male C57BL / 6J mice weighing 25 - 30 g were randomly divided into 3 groups (n = 5 in each group) and given 4 mg / gBW, 6 mg / gBW, and 8 mg / gBW respectively. The righting reflex was used as the criterion for judging the degree of drunkenness. That is, the mouse's back was placed on the ground with its abdomen and limbs facing upwards. If the mouse could not turn over within 30 seconds, it was considered to have lost the normal righting reflex. The time point when the righting reflex disappeared was defined as the drunken point, and the time point between the first drinking and drunkenness was defined as the alcohol tolerance time. The alcohol tolerance time of the three groups of mice was less than 20 minutes. To exclude the influence of individual differences, mice that did not lose the righting reflex within 1 h were considered not to be acutely drunk. Considering the drunkenness rate and safety, a dose of 6 mg / gBW was selected for the subsequent experiment, and the results are shown in Table 1 below.

[0140] Table 1. Establishment of the mouse drunkenness model. 6 mg / gBW alcohol was selected as the treatment dose

[0141]

[0142] Thirty mice were selected and divided into three groups, namely 10 mice in the normal group (G1), 10 mice in the model control group (G2), and 10 mice in the tea drink administration group (G3). The correspondence between the group and the animal number is shown in Table 5.

[0143] Table 2 Animal grouping situation

[0144]

[0145] Note: The first digit of the animal number represents the group (2 and 3 represent the model control group and the tea drink administration group respectively), the second digit represents the gender (0 for female, 1 for male), and the third and fourth digits represent the animal serial number. After grouping, the animals were removed for euthanasia.

[0146] Ear punching (completed during the quarantine period) and cage cards were used for identification, with 5 mice per cage. The cage cards indicated information such as the test code, cage number, animal number, animal gender, dose, name of the test article / control article, start and end dates of drug administration, and the person in charge of the project, and were hung on the front of the breeding cage. See Table 5 for details.

[0147] The dosage of this extract in animal experiments was 0.6 mg / kg. Route of administration and selection basis: Oral administration. Administration frequency: 2 times, half an hour before alcohol administration and 15 min after alcohol administration, for a total of 1 day. Dosage: kg / 10 mL

[0148] Observe the activities of the mice after getting drunk, and record in time the disappearance of the righting reflex of the drunk mice, the recovery time of the righting reflex, the drunken latency period, and the sobering-up time. The standard for the disappearance time of the righting reflex is that the drunk mouse lies on its back for 30 s; the standard for the recovery of the righting reflex is that the mouse is flexible and its fur is smooth; the drunken latency period is equal to the disappearance time of the righting reflex minus the time of giving alcohol; the sobering-up time is equal to the recovery time of the righting reflex minus the time of giving alcohol. After the last alcohol administration, place the mice in the locomotor activity detection system respectively, and detect their movements every 15 seconds. When the mouse is drunk, the reading of the machine is 0. When the number of movements at four consecutive recording time points is not zero, the mouse is considered to have recovered its motor ability.

[0149] One hour after drug administration, the mice were sacrificed by cervical dislocation. According to the ratio of liver weight (g): 0.9% normal saline (mL) = 1:9, mechanical homogenization was carried out under ice-water bath conditions to prepare 10% tissue homogenate, and centrifuged at 3000 rpm / min for 10 min. Take the supernatant part after centrifugation and detect it according to the method described in the kit.

[0150] One hour after drug administration, blood was collected from the eyeballs, centrifuged at 3000 rpm / min for 20 min, and the supernatant after centrifugation was taken, and detected according to the method described in the kit. The detection indexes were ALT and AST.

[0151] One hour after drug administration, blood was collected and the mice were sacrificed. After taking out the liver, it was fixed with formalin and subjected to histopathological examination to observe the morphological changes of the liver tissue.

[0152] As shown in Table 3, the drunken latency period (32.00±4.00) of the extract administration group was longer than that of the model group (26.00±2.00), and its sobering-up time (317.00±89.00) of the administration group was longer than that of the model group (281.00±60.01), indicating that the extract administration group could significantly prolong the drunken latency period and the sobering-up time. The above result that the sobering-up time was prolonged might be due to the effect of the sleep-aid components in the extract. Therefore, it was inferred that the extract might have the effects of helping sleep and sobering up.

[0153] Table 3 Effects of drugs on drunken latency period, sobering-up time and locomotor activity of mice

[0154]

[0155] The number of spontaneous activities of mice is an index for evaluating the functional state of the central nervous system in pharmacology, and it is manifested as an increase in the number of spontaneous activities of mice after intoxication. As can be seen from Table 4, the total distance (5806.29±313.51 cm), average speed (4.84±0.26 cm / second), and total number of activities (6345.31±259.57 times) of the mice in the administration group were significantly higher than those of the control group mice with a total distance of (2914.84±197.59 cm), an average speed of (2.25±1.14 cm / second), and a total number of activities of (4259.22±2119.81 times). The above research results indicate that after administration, it can accelerate the metabolism of alcohol in the body and alleviate the phenomenon of paralysis in mice after drinking.

[0156] Table 4 Effects of drugs on the drunkenness latency, sobering time, and spontaneous activities of mice

[0157]

[0158] Alcohol dehydrogenase (ADH) is abundantly present in the livers of humans and animals, plant, and microbial cells. It is a zinc-containing metalloenzyme with broad substrate specificity. Alcohol dehydrogenase can use nicotinamide adenine dinucleotide (NAD) as a coenzyme to catalyze the reversible reaction between primary alcohols and aldehydes: CH3CH2OH + NAD+ → CH3CHO + NADH + H+. In humans and mammals, alcohol dehydrogenase and aldehyde dehydrogenase (ALDH) constitute the alcohol dehydrogenase system, which participates in the metabolism of ethanol in the body and is an important metabolic enzyme in humans and animals. As a key enzyme for the metabolism of major short-chain alcohols in the body, it plays an important role in many physiological processes. The alcohol dehydrogenase ethanol oxidation system is a major pathway for metabolizing alcohol in the liver. From Table 5-1 and Figure 1 it can be seen that compared with the model group (1.597±0.512), the ADH enzyme activity of the experimental group of mice taking the extract in the administration group (1.810±0.759) showed an increasing trend and basically reached the normal group level. The above results indicate that the extracts can all increase the ADH enzyme activity in the livers of mice, accelerate the metabolism of alcohol in the body, and reduce the toxic and side effects brought by alcohol to the body.

[0159] Table 5-1 ADH content and sample number in the livers of mice in each group

[0160]

[0161]

[0162] Malondialdehyde (MDA) is closely associated with lipid peroxidation damage. In living organisms, the lipid peroxidation reaction induced by free radicals can lead to the cross-linking and polymerization of important biological macromolecules such as proteins and nucleic acids, and then produce cytotoxicity, which is the essence of lipid peroxidation damage. As one of the end products of the lipid peroxidation reaction, the level of MDA directly reflects the degree of tissue lipid peroxidation damage. Therefore, the detection of MDA is of great significance for evaluating tissue damage. From Table 5-2 and Figure 2 it can be seen that the MDA content in the liver of the model group mice (6.29 ± 2.57) is relatively high, and the MDA content in the administration group (5.66 ± 1.87) shows a decreasing trend compared with the control group. Compared with the model group, the administration group has a better trend in inhibiting the MDA content, indicating that the extract can protect the liver tissue from alcohol damage.

[0163] Table 5-2 MDA content and sample number in the liver of mice in each group

[0164]

[0165] Superoxide Dismutase (SOD) is a metal enzyme widely present in living organisms, which can catalyze the dismutation of superoxide free radicals (O2 - ) into oxygen (O2) and hydrogen peroxide (H2O2), thereby scavenging free radicals and protecting cells from oxidative damage. The biological activity of SOD is very extensive. 1) Antioxidant effect: SOD scavenges superoxide free radicals, reduces oxidative stress, and protects cells from free radical damage. 2) Anti-inflammatory effect: SOD inhibits the inflammatory response and reduces inflammatory damage by reducing free radicals. 3) Anti-aging effect: SOD delays cell aging and prolongs cell lifespan by scavenging free radicals. 4) Immunomodulation: SOD affects the function of immune cells and enhances immunity by regulating the level of free radicals. 5) Protection of cardiovascular system: SOD protects the cardiovascular system by scavenging free radicals and reducing lipid peroxidation. 6) Neuroprotection: SOD protects the nervous system by scavenging free radicals and reducing nerve cell damage. From Table 5-3 and Figure 3 it can be seen that compared with the SOD activity in the model group (14.58 ± 6.14), the SOD activity in the administration group (36.22 ± 2.71) is significantly increased (p < 0.05). The above results indicate that the crude extract can improve the antioxidant capacity of drunken mice and has a good effect on protecting liver cells.

[0166] Table 5-3 SOD content and sample number in the liver of mice in each group

[0167]

[0168] Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine, which is widely present in organisms. It is one of the most important non-protein thiol compounds in cells and has various functions such as antioxidant, detoxification, and regulation of cell metabolism. The biological significance of GSH is as follows: 1) Antioxidant effect: GSH is an important antioxidant in cells, which can directly scavenge free radicals, protect cells from oxidative damage, and also participate in the process of reducing oxidized glutathione (GSSG) to maintain the intracellular redox balance; 2) Detoxification effect: GSH binds to toxins to form complexes that are easily excreted, helping cells detoxify. In particular, it also participates in the detoxification process in the liver to help remove exogenous toxins and drugs; 3) Regulation of cell metabolism: GSH participates in the transport and metabolism of amino acids, affecting protein synthesis and degradation; 4) Immunomodulation: GSH enhances the body's immune response by regulating the functions of immune cells. From Table 5-4 and Figure 4 it can be seen that compared with the GSH content (19.08 ± 2.93) in the model group, the GSH content (21.55 ± 5.16) in the administration group is also higher than that in the model group and tends to be normal. The above results indicate that the crude extract can improve the detoxification effect of drunken mice and has a good effect on protecting liver cells.

[0169] Table 5-4 GSH content and sample number in the livers of mice in each group

[0170]

[0171] Alanine Aminotransferase (ALT) is an enzyme mainly present in the cytoplasm of liver cells, which catalyzes the aminotransfer reaction between alanine and α-ketoglutaric acid to generate pyruvic acid and glutamic acid. Aspartate Aminotransferase (AST) is an enzyme widely present in various tissues (such as liver, heart, muscle, kidney, and brain), which catalyzes the aminotransfer reaction between aspartic acid and α-ketoglutaric acid to generate oxaloacetic acid and glutamic acid. ALT participates in the metabolism of amino acids, especially plays an important role in the conversion between alanine and glutamic acid, and participates in gluconeogenesis by generating pyruvic acid to help maintain blood glucose levels. Most importantly, ALT is mainly present in liver cells, and its serum level is commonly used to evaluate liver cell damage and liver function status. The biological role of AST is similar to that of ALT, also participating in the metabolism of amino acids, especially playing an important role in the conversion between aspartic acid and glutamic acid, and participating in the tricarboxylic acid cycle (TCA cycle) by generating oxaloacetic acid to affect cell energy metabolism. An increase in the serum level of AST can be used to evaluate the damage of various tissues (such as liver, heart, muscle). From Table 6 and Figure 5It can be seen that, compared with ALT (18.73±4.53) and AST (18.34±9.283) in the model group, the contents of ALT (10.21±4.30) and AST (9.68±5.29) in the administration group were significantly decreased (p<0.001, p<0.05). The above results indicate that the crude extract has significant hepatoprotective ability.

[0172] Table 6 Determination results of AST and ALT contents in the sera of mice in each group

[0173]

[0174]

[0175] The results of the morphological changes of liver tissues showed that no phenomenon of hepatocyte injury occurred in either the administration group or the model group.

[0176] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A tea granule for clearing liver and removing dampness, characterized in that: The invention comprises the following raw materials in parts by weight: 8-12 parts of Hovenia dulcis, 4-6 parts of Pueraria lobata flower, 8-12 parts of Poria cocos, 5-8 parts of dried tangerine peel, 5-8 parts of Perilla stem, 5-8 parts of Gardenia jasminoides, 5-8 parts of Prunella vulgaris, 2-4 parts of Amomum villosum, 50-60 parts of xylitol, 0.2-0.4 parts of L-malic acid and 8-29 parts of functional composition.

2. The tea granules for clearing liver and removing dampness according to claim 1, characterized in that: The functional composition includes a liver protection and strengthening composition, an intestinal regulation composition, a body constitution balancing composition, and a flavor functional composition, and the weight portions thereof are 3 to 7 parts, 8 to 16 parts, 8 to 14 parts, and 1 to 2 parts, respectively.

3. The tea granules for clearing liver and removing dampness according to claim 2, characterized in that: The liver protection and strengthening composition includes milk thistle and turmeric in a weight ratio of 2-4:1-3, the milk thistle is a milk thistle extract, wherein the silymarin content is ≥80%, the turmeric is turmeric powder or curcumin extract with a curcumin content of ≥95%, and the intestinal regulating composition includes oligofructose and hericium erinaceus in a weight ratio of 5-10:3-6, the oligofructose is a fructan mixture with a polymerization degree of 2-9, and the hericium erinaceus is hericium erinaceus micropowder with a particle size of ≤100 mesh and a polysaccharide content of ≥30% or hericium erinaceus polysaccharide extract.

4. The tea granules for clearing liver and removing dampness according to claim 2, characterized in that: The body constitution balancing composition comprises wolfberry and corn silk in a weight ratio of 5-8:3-6. The corn silk is dry corn silk, a water extract with an extraction rate of ≥15% or corn silk micro powder with a particle size of ≤100 meshes. The wolfberry is a dry mature fruit powder of wolfberry with a particle size of ≤80 meshes. The flavor functional composition is one of mint, chrysanthemum and honeysuckle.

5. A method for preparing tea granules for clearing liver and removing dampness, characterized in that: The tea granules for clearing liver and removing dampness as claimed in any one of claims 1 to 4 comprise the following steps: S1. Mix Hovenia dulcis, Pueraria lobata, Poria cocos, Tangerine peel, Perilla frutescens, Gardenia jasminoides, Prunella vulgaris, and Amomum villosum according to weight, crush and sieve to obtain a material, and sieve xylitol and L-malic acid respectively; S2, mixing milk thistle and turmeric according to weight ratio to form a liver protection strengthening composition, mixing oligofructose and Hericium erinaceus to form an intestinal regulation composition, mixing wolfberry and corn silk to form a physical balance composition, and mixing the liver protection strengthening composition, intestinal regulation composition, physical balance composition, and flavor functional composition according to weight ratio to form a functional composition; S3, adding purified water to the material, heating and boiling after soaking and keeping it slightly boiling, filtering and collecting the first filtrate, and then adding purified water again, decocting and filtering, combining with the first filtrate, centrifuging and taking the supernatant to obtain a clarified extract; S4, concentrating the clarified extract to a relative density, preheating, spray drying, and then collecting and sieving to obtain a Chinese medicine extract powder; S5, putting the sieved xylitol, L-malic acid, Chinese medicine extract powder and functional composition into a three-dimensional mixer, mixing to obtain a mixed dry powder, adding hydroxypropyl methylcellulose to purified water to prepare a binder solution, putting the mixed dry powder into a tank mixer, adding the binder solution while stirring and continuing to stir to prepare a soft material; S6. The soft material is made into wet granules by a rocking granulator, the wet granules are spread on a drying tray, dried, and then sieved to obtain tea granules for clearing the liver and removing dampness.

6. The method for preparing the tea granules for clearing liver and removing dampness according to claim 5, characterized in that: The mesh number of the crushing and sieving in S1 is 40 meshes, the mesh number of the separate sieving is 80 meshes, and the mixing in S2 adopts a three-dimensional mixer or a tank mixer.

7. The method for preparing the tea granules for clearing liver and removing dampness according to claim 5, characterized in that: The amount of purified water added to S3 is 8-10 times the weight of the material, the soaking time is 30 minutes, the temperature for maintaining a slight boil is 95-100°C, and the time is 30 minutes. The amount of purified water added again is 6-8 times the weight of the material, the decoction time is 20 minutes, the centrifugal speed is 3000r / min, and the centrifugal time is 10 minutes.

8. The method for preparing the tea granules for clearing liver and removing dampness according to claim 5, characterized in that: The concentration temperature in S4 is 60-70°C, the vacuum degree is -0.06MPa, the relative density is 1.15-1.2, the preheating temperature is 50°C, the feed flow rate of the spray drying is 20-30mL / min, the inlet temperature is 175-185°C, the outlet temperature is 75-85°C, and the mesh size of the sieving is 80 meshes.

9. The method for preparing the tea granules for clearing liver and removing dampness according to claim 5, characterized in that: The mixing rate in S5 is 30 r / min, the time is 20 min, the temperature of the purified water is 50° C., the amount of hydroxypropyl methylcellulose added is 0.2%-0.3% of the total mass, the concentration of the adhesive solution is 5%, the continuous stirring rate is 15-20 r / min, the time is 10 min, and the water content of the soft material is 18%-22%.

10. The method for preparing the tea granules for clearing liver and removing dampness according to claim 5, characterized in that: The diameter of the wet particles in S6 is 2-4 mm, the drying temperature is 58-62° C., the wind speed is 0.5-1.0 m / s, the drying time is 4-6 h, the moisture content after drying is ≤5%, and the sieving and granulating is to pass through a 16-mesh sieve to remove fine powder and lumps.

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