Bird's nest acid composition with whitening and skin state improving functions and preparation method thereof
Through the composition guided by traditional Chinese medicine theory, bird's nest acid and medicinal materials are used to solve the shortcomings of bird's nest acid in the field of oral whitening, and the effect of improving the skin's water retention ability and elasticity is achieved. It is suitable for whitening and delaying skin aging.
Patent Information
- Application Number
- CN202510232246.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-28
- Publication Date
- 2025-06-20
AI Technical Summary
The prior art is difficult to enable bird's nest acid to play a more fully role in the field of oral whitening.
Through the guidance of traditional Chinese medicine theory, combined with medicinal and food homologous medicinal materials and modern nutritional ingredients, a composition composed of bird's nest acid, poria cocos, yam, lily, pyramid, peach kernel, double-petal rose and pyrroloquinoline quinone disodium salt is used to jointly play the role of whitening and improving skin condition.
Effectively improves the skin's water retention ability and elasticity, has the effects of whitening, reducing wrinkles and delaying skin aging, and is suitable for the promotion and application of oral beauty products.
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Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of functional foods, and particularly to a sialic acid composition having the functions of whitening and improving skin condition and a preparation method thereof. Background Art
[0002] In recent years, the trend of oral beauty has grown rapidly and has become the focus of attention. So far, a large number of consumers have chosen diet as the preferred method to improve skin problems, significantly enhancing the status of the oral whitening industry and creating a broad market prospect for oral beauty.
[0003] Sialic acid, scientifically named N-acetylneuraminic acid and also known as neuraminic acid, is a natural functional nutrient component. It mainly exists in the form of cell membrane glycoproteins, glycolipids, etc. in various biological tissues and has physiological functions such as promoting brain development, improving memory, whitening and anti-aging, antiviral, enhancing immunity, and promoting intestinal health, and is applied in the fields of food, cosmetics, etc.
[0004] However, how to make sialic acid play a more sufficient role in the field of oral whitening remains to be further studied. Summary of the Invention
[0005] In order to solve the problems existing in the prior art, the present invention provides a sialic acid composition having the functions of whitening and improving skin condition and a preparation method thereof.
[0006] Guided by traditional Chinese medicine theory, the present invention starts from the functions of soothing the liver and relieving depression, strengthening the spleen and moistening the lungs: Traditional Chinese medicine believes that the luster of a person's skin is closely related to the functions of the zang-fu organs. Among them: The liver stores blood. If the liver blood is insufficient, the face will not be nourished enough and will become dull. The liver governs dispersion and catharsis. Stagnation of liver qi will also lead to unsmooth flow of qi and blood, and then pigmentation will appear in parts such as the face, forming age spots. "Huangdi Neijing" says: The lung governs the skin and hair. Through its dispersing function, the lung transports qi, blood, and body fluids to the skin and hair to warm and nourish them and maintain their normal physiological functions. If the lung is not nourished, a series of skin problems such as dull complexion, enlarged pores, and dry and rough skin are likely to occur in the human body. The spleen is the source of qi and blood production. Its normal function can ensure sufficient qi and blood, thus nourishing the skin. The spleen governs muscles. If the spleen qi is healthy and transports smoothly, the muscles will be firm and elastic. If the spleen fails to transport and transform properly, qi and blood cannot nourish the muscles, or phlegm-dampness accumulates between the muscles and the interstices, and the relaxation of the facial muscles will occur. The spleen and stomach belong to earth, and the lung belongs to metal. Earth generates metal. Only when the digestion and absorption functions of the spleen and stomach are good can the primordial qi and qi and blood nourish the skin.
[0007] The present invention uses medicinal and edible homologous herbs and modern nutrients as the main raw materials, and each component adopts an appropriate compatibility ratio to synergistically play the role of whitening and improving skin condition. The formula of the present invention is reasonable and the compatibility is proper. In the formula, sialic acid, Poria cocos, Chinese yam, Lily brownii, Polygonatum odoratum, peach kernel, and Rosa rugosa are the monarch drugs. Among them, sialic acid can inhibit the activities of tyrosine hydroxylase and dopa hydroxylase; promote cell division and proliferation; repair broken and deformed collagen fibers and elastic fibers; have antioxidant effect and reduce the generation of free radicals; the medicinal and edible homologous herbs, Poria cocos + Chinese yam strengthen the spleen and promote diuresis and dampness elimination; Lily brownii + Polygonatum odoratum nourish body fluids and moisten the lungs; peach kernel + Rosa rugosa promote blood circulation and moisten dryness, nourish the skin, and improve skin microcirculation. Pyrroloquinoline quinone disodium salt (PQQ) is the ministerial drug, with antioxidant effect and inhibiting the activity of tyrosinase; licorice is used as the assistant and guiding drug to harmonize all the drugs. The combination of the above monarch, ministerial, assistant, and guiding drugs can achieve the effects of whitening and improving skin condition by soothing the liver and relieving depression, strengthening the spleen and moistening the lungs, and having antioxidant effect. The selected herbs in the traditional Chinese medicine preparation of the present invention have appropriate compatibility, conform to the theories of traditional Chinese medicine and modern medicine, are convenient to use, have good absorption effect, have no adverse and toxic side effects, and through clinical verification, have the effects of whitening the skin, maintaining skin elasticity, reducing wrinkles, and delaying skin aging, and are suitable for the popularization and application of oral beauty products.
[0008] In the first aspect, the present invention provides a composition, comprising: sialic acid, Poria cocos, Chinese yam, Lily brownii, Polygonatum odoratum, peach kernel, Rosa rugosa, and pyrroloquinoline quinone disodium salt; By weight, sialic acid is 8 - 18 parts, the sum of Poria cocos and Chinese yam is 2 - 12 parts, the sum of Lily brownii and Polygonatum odoratum is 2 - 12 parts, the sum of peach kernel and Rosa rugosa is 2 - 12 parts, and pyrroloquinoline quinone disodium salt is 1 - 6 parts.
[0009] Further, by weight, it comprises: 8 - 18 parts of sialic acid, 1 - 6 parts of Poria cocos, 1 - 6 parts of Chinese yam, 1 - 6 parts of Lily brownii, 1 - 6 parts of Polygonatum odoratum, 1 - 6 parts of peach kernel, 1 - 6 parts of Rosa rugosa, and 1 - 6 parts of pyrroloquinoline quinone disodium salt.
[0010] Further, by weight, it comprises: 10 - 15 parts of sialic acid, 2 - 5 parts of Poria cocos, 2 - 5 parts of Chinese yam, 2 - 5 parts of Lily brownii, 2 - 5 parts of Polygonatum odoratum, 2 - 5 parts of peach kernel, 2 - 5 parts of Rosa rugosa, and 2 - 5 parts of pyrroloquinoline quinone disodium salt.
[0011] Further, it further comprises: licorice; by weight, the licorice is 1 - 6 parts.
[0012] Further, the Poria cocos is Poria cocos extract, the Chinese yam is Chinese yam extract, the Lily brownii is Lily brownii extract, the Polygonatum odoratum is Polygonatum odoratum extract, the peach kernel is peach kernel extract, and the Rosa rugosa is Rosa rugosa extract.
[0013] Second aspect, the present invention provides a method for preparing the foregoing composition, comprising: mixing sialic acid, Poria cocos, Chinese yam, lily, polygonatum odoratum, peach kernel, double-petal rose flower, pyrroloquinoline quinone disodium salt and liquorice in a predetermined ratio.
[0014] Further, if it is prepared into a liquid preparation, the mixture is subsequently dissolved in water, and after mixing evenly, it is canned and sterilized.
[0015] Further, if it is prepared into tablets, the mixture is subsequently granulated, sized and tabletted.
[0016] Further, if it is prepared into granules, each raw material is dried, pulverized and sieved to obtain uniform raw material granules, and then all the raw materials are mixed.
[0017] Third aspect, the present invention provides a product comprising the foregoing composition; the product is a food, a health product or a drug.
[0018] Further, the product is an oral whitening product, and the product is one or more of a liquid preparation, a capsule preparation, a tablet, a pill, a powder or a jelly preparation.
[0019] Correspondingly, according to the dosage form of the product, different acceptable carriers can be added during the preparation of the product.
[0020] Further, in the product, the concentration of the composition is 0.5-2% (w / w).
[0021] Third aspect, the present invention provides the application of the foregoing composition, or the foregoing product in whitening or improving skin condition.
[0022] Further, the improvement of skin condition includes: increasing the water content of the skin and / or improving the elasticity of the skin.
[0023] The present invention further provides the application of the foregoing composition in the preparation of a product for whitening or improving skin condition.
[0024] The product is a food, a health product or a drug, preferably an oral whitening product.
[0025] The present invention has the following beneficial effects: The present invention researches and develops a composition with the functions of whitening and improving skin condition based on the addition of sialic acid. Through the compatibility of sialic acid and several medicinal and edible homologous herbs, the functions of whitening and improving skin condition are synergistically exerted. The product provided by the present invention can effectively improve the water retention capacity and elasticity of the skin, meet the current market demand, and is of great significance for promoting the development of oral beauty products. Detailed Embodiments
[0026] To make the objectives, technical solutions, and advantages of the present invention clearer, the technical solutions in the present invention will be clearly and completely described below. Apparently, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present invention without creative efforts fall within the scope of protection of the present invention.
[0027] For the experimental methods involved in the following embodiments, unless otherwise specified, they are all conventional methods in the art. For example, they can be referred to the experimental manuals in the art or carried out according to the conditions recommended in the manufacturer's instructions.
[0028] For the experimental materials and reagents involved in the following embodiments, unless otherwise specified, they can all be obtained from commercial channels.
[0029] All kinds of traditional Chinese medicine extracts involved in the following embodiments are purchased commercially (such as Guangdong Qingyunshan Pharmaceutical Co., Ltd.).
[0030] The parts defined in the present invention are parts by weight and can be any weight unit. In the following embodiments, they are preferably grams (g).
[0031] Example 1 This example provides a composition with the functions of whitening and improving skin condition, which is prepared by the following method: 1. Weigh the selected raw and auxiliary materials according to the following ratio: 10 parts of sialic acid, 2 parts of Poria cocos extract, 2 parts of Dioscorea opposita extract, 2 parts of Lilium brownii extract, 2 parts of Polygonatum odoratum extract, 2 parts of Prunus persica extract, 2 parts of Rosa rugosa cv. plena extract, 2 parts of Glycyrrhiza glabra extract, and 2 parts of pyrroloquinoline quinone disodium salt (PQQ).
[0032] 2. Mix the Poria cocos extract, Dioscorea opposita extract, Lilium brownii extract, Polygonatum odoratum extract, Prunus persica extract, Rosa rugosa cv. plena extract, Glycyrrhiza glabra extract, sialic acid, and pyrroloquinoline quinone disodium salt (PQQ), and dissolve them with purified water.
[0033] 3. Filter through a 0.45 μm microporous filter membrane after fully stirring and mixing to obtain the composition.
[0034] 4. Fill the composition into cans and sterilize at 105 °C for 30 min. Each bottle is 30 mL.
[0035] Example 2 This example provides a composition with the functions of whitening and improving skin condition, which is prepared by the following method: 1. Weigh the selected raw and auxiliary materials according to the following ratio: 12 parts of sialic acid, 3 parts of poria cocos extract, 3 parts of yam extract, 3 parts of lily extract, 3 parts of polygonatum odoratum extract, 3 parts of peach kernel extract, 3 parts of rosa rugosa cv. Plena extract, 3 parts of licorice extract, and 3 parts of pyrroloquinoline quinone disodium salt (PQQ).
[0036] 2. Pass the selected raw and auxiliary materials through a 60-mesh sieve respectively to make the particle size distribution uniform, improve the fluidity, and keep them dry.
[0037] 3. Weigh the selected raw and auxiliary materials according to the ratio in step 1. 4. Mix the raw and auxiliary materials and stir evenly. 5. Granulate the mixed raw and auxiliary materials in a granulator, dry them, and then screen them. 6. Put them into a tablet press, adjust the parameters of the tablet press, and press tablets. The theoretical tablet weight is 500 mg. Example 3 This example provides a composition with the functions of whitening and improving skin condition, which is prepared by the following method: 1. Weigh the selected raw and auxiliary materials according to the following ratio: 13 parts of sialic acid, 4 parts of poria cocos extract, 4 parts of yam extract, 4 parts of lily extract, 4 parts of polygonatum odoratum extract, 4 parts of peach kernel extract, 4 parts of rosa rugosa cv. Plena extract, 4 parts of licorice extract, and 4 parts of pyrroloquinoline quinone disodium salt (PQQ).
[0038] 2. Pass the selected raw and auxiliary materials through a 60-mesh sieve respectively to make the particle size distribution uniform, improve the fluidity, and keep them dry. 3. Weigh the selected raw and auxiliary materials according to the ratio in step 1. 4. Mix the raw and auxiliary materials evenly to obtain the composition.
[0039] Experimental Example 1 1. Experimental subjects The effective sample size is 30 people, all female, aged 21 to 40 years old, with an average age of 30.77 ± 6.13 years. The skin type of the subjects is Asian skin, meeting the volunteer selection criteria for the subjects.
[0040] 2. Experimental method Each person uses 2 bottles (for oral consumption) of the product prepared in Example 1 every day.
[0041] 3. Experimental results (1) Moisture content of the skin stratum corneum The moisture content of the stratum corneum of the skin was detected at different time points (0 day, 14 days, and 28 days), and the "Test Methods for Seven Efficacy of Cosmetics: Anti-Wrinkle, Firming, Moisturizing, Oil Control, Repair, Nourishing, and Soothing" of T / CAB 0152-2022 was adopted.
[0042] The results are shown in the following table: Table 1 Detection values of the moisture content of the facial stratum corneum at different time points (unit: a.u.) N = 30
[0043] Note: Rate of change = (measured value after use - measured value before use) / measured value before use * 100% Note: Compared with before use, the difference was statistically significant. "*" indicates 0.01 < P ≤ 0.05; "**" indicates P ≤ 0.01; "n.s" indicates ≥ 0.05.
[0044] It can be seen from the above results that continuous use of the composition provided in Example 1 of the present invention can effectively increase the moisture content of the facial stratum corneum.
[0045] (2) Skin elasticity-related indicators The skin elasticity-related indicators were detected at different time points (0 day, 14 days, and 28 days) in the present invention. The skin elastic recovery rate and skin firmness were detected by using the "Test Methods for Seven Efficacy of Cosmetics: Anti-Wrinkle, Firming, Moisturizing, Oil Control, Repair, Nourishing, and Soothing" of T / CAB 0152-2022; R2 and R5 represent the resilience of the skin after being stretched; F4 is the skin relaxation and firmness index. The following results were finally obtained: Table 2 Detection values of the facial skin elasticity parameter R2 at different time points (unit: %) N = 30
[0046] Table 3 Detection values of the facial skin elasticity parameter R5 at different time points (unit: %) N = 30
[0047] Table 4 Detection values of the facial skin elasticity parameter F4 at different time points (unit: mm*s) N = 30
[0048] It can be seen from the above results that continuous use of the composition provided in Example 1 of the present invention can effectively improve the facial skin elasticity.
[0049] (3) Consumer use test data The present invention further conducted consumer use evaluations at different time points (14 days and 28 days), and the following results were obtained Table 5 Evaluation Results of Product Efficacy by Consumers after 14 Days and 28 Days of Using Test Sample
[0050] Note: TOP2 = Proportion of people who answered "strongly agree" + Proportion of people who answered "agree".
[0051] All of the above TOP2 (%) had significant differences under the condition of a test ratio of 0.4:0.6. "*" indicates 0.01 < P ≤ 0.05; "**" indicates P ≤ 0.01.
[0052] Experimental Example 2 To verify the improvement effect of sialic acid on the skin, the present invention conducted a efficacy comparison test.
[0053] 1. Experimental Subjects The effective sample size was 30 people, all female, aged 21 to 40 years old, with an average age of 30.77 ± 6.13. The skin type of the subjects was Asian skin, meeting the voluntary inclusion criteria for the subjects.
[0054] 2. Experimental Method Each person consumed 2 bottles of the control group product (equivalent to that in Experimental Example 1) per day.
[0055] The control group product did not include sialic acid based on Example 1, and included: 3.25 parts of Poria cocos extract, 3.25 parts of Dioscorea opposita extract, 3.25 parts of Lilium brownii extract, 3.25 parts of Polygonatum odoratum extract, 3.25 parts of Prunus persica extract, 3.25 parts of Rosa rugosa cv. plena extract, 3.25 parts of Glycyrrhiza glabra extract, and 3.25 parts of pyrroloquinoline quinone disodium salt (PQQ). It was prepared by the same method as in Example 1.
[0056] 3. Experimental Results (1) Moisture Content of Skin Stratum Corneum The present invention detected the moisture content of the skin stratum corneum at different time points (0 day, 14 days, and 28 days), and used the moisture efficacy determination method in T / CAB 0152-2022 "Test Methods for Seven Efficacy of Cosmetics: Anti-Wrinkle, Firming, Moisturizing, Oil Control, Repair, Nourishment, and Soothing" to detect the moisture content of the skin stratum corneum.
[0057] The results are shown in the following table: Table 1 Detected Values of Facial Skin Stratum Corneum Moisture Content at Different Time Points (Unit: a.u.) N = 30
[0058] Note: Change rate = (Measured value after use - Measured value before use) / Measured value before use * 100% Note: Compared with before use, the differences are statistically significant. "*" indicates 0.01 < P ≤ 0.05; "**" indicates P ≤ 0.01; "n.s" indicates P ≥ 0.05.
[0059] As can be seen from the above results, continuous use of the composition provided in Example 2 of the present invention can increase the water content in the stratum corneum of facial skin.
[0060] (2)Skin elasticity-related indicators The present invention detects skin elasticity-related indicators at different time points (0 days, 14 days, and 28 days), and uses the method of T / CAB 0152-2022 "Test Methods for Seven Efficacy of Cosmetics: Anti-wrinkle, Firming, Moisturizing, Oil Control, Repair, Nourishing, and Soothing" to detect the skin elasticity recovery rate and skin firmness indicators, and obtains the following results: Table 2 Detection values of facial skin elasticity parameter R2 at different time points (unit: %) N = 30
[0061] Table 3 Detection values of facial skin elasticity parameter R5 at different time points (unit: %) N = 30
[0062] Table 4 Detection values of facial skin elasticity parameter F4 at different time points (unit: mm*s) N = 30
[0063] As can be seen from the above results, continuous use of the composition provided in Example 2 of the present invention can improve facial skin elasticity.
[0064] (3)Consumer usage test data The present invention further conducts consumer usage evaluations at different time points (14 days and 28 days), and obtains the following results Table 5 Evaluation results of product efficacy by consumers after using the test samples for 14 days and 28 days
[0065] The above TOP2 (%) all have significant differences under the condition of a test ratio of 0.4:0.6. "*" indicates 0.01 ≤ P ≤ 0.05; "**" indicates P ≤ 0.01.
[0066] Comparison of product efficacy between Example 1 and the control group: (1)Comparison of the efficacy of skin stratum corneum water content: Table 6 Comparison of the efficacy of skin stratum corneum water content
[0067] (2)Comparison of the efficacy of skin elasticity-related indicators: Table 7 Comparison of the efficacy of skin elasticity-related indicators
[0068] (3)Consumer usage test data Table 8 Comparison of consumer usage test results
[0069] Through the comparative experiment, it was found that the component with sialic acid added in Example 1 had a better effect on skin improvement than the component without sialic acid added in the control group, and there was a significant difference. This shows that the combination of the traditional Chinese medicine composition and bird's nest in the present invention has a significant effect on improving the skin state, such as significantly increasing the water content of the skin and improving the skin elasticity (the improvement effect of sialic acid itself on the skin state such as skin water content and elasticity is significantly inferior to that of the traditional Chinese medicine composition).
[0070] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the present invention.
Claims
1. A composition, characterized in that include: Swallow’s nest acid, Poria cocos, Chinese yam, lily, polygonatum odoratum, peach kernel, double rose flower and pyrroloquinoline quinone disodium salt; In parts by weight, the amount of bird's nest acid is 8-18 parts, the amount of Poria cocos and Chinese yam is 2-12 parts, the amount of lily and Polygonatum odoratum is 2-12 parts, the amount of peach kernel and double rose is 2-12 parts, and the amount of pyrroloquinoline quinone disodium salt is 1-6 parts.
2. The composition according to claim 1, characterized in that In parts by weight, it includes: 10-15 parts of swiftlet acid, 2-6 parts of tuckahoe, 2-6 parts of yam, 2-6 parts of lily, 2-6 parts of polygonatum odoratum, 2-6 parts of peach kernel, 2-6 parts of double rose and 2-6 parts of pyrroloquinoline quinone disodium salt.
3. The composition according to claim 1 or 2, characterized in that Also includes: Licorice; In parts by weight, the liquorice is 1 to 6 parts.
4. The composition according to any one of claims 1 to 3, characterized in that The Poria cocos is a Poria cocos extract, the Chinese yam is a Chinese yam extract, the lily is a lily extract, the polygonatum odoratum is a polygonatum odoratum extract, the peach kernel is a peach kernel extract, and the double-petal rose is a double-petal rose extract.
5. The method for preparing the composition according to any one of claims 1 to 4, characterized in that: include: Bird's nest acid, Poria cocos, Chinese yam, lily, polygonatum odoratum, peach kernel, double rose, pyrroloquinoline quinone disodium salt and liquorice are mixed according to a predetermined ratio.
6. A product, characterized in that The composition comprises any one of claims 1 to 4; the product is a food, a health product or a medicine.
7. The product according to claim 6, characterized in that The product is an oral whitening product, and the product is one or more of a liquid preparation, a capsule preparation, a tablet, a pill, a powder or a jelly preparation.
8. The product according to claim 6 or 7, characterized in that In the product, the content of the composition is 0.5-2%.
9. Use of the composition according to any one of claims 1 to 4 or the product according to any one of claims 6 to 8 in whitening or improving skin condition.
10. The use according to claim 9, characterized in that: Improving skin condition includes: increasing the moisture content of the skin and / or improving the elasticity of the skin.