Laminate provided with synthetic polymer film having antibacterial and / or antiviral properties, and method for producing same

Abstract

Provided is a method for producing a laminate provided with a synthetic polymer film having antibacterial and / or antiviral properties. A method for producing a laminate provided with a synthetic polymer film having antibacterial and / or antiviral properties, the method comprising: preparing a laminate (50A) having a base material (42) and a synthetic polymer film (34A) formed on the base material, the synthetic polymer film (34A) having, on the surface thereof, a cross-linking agent (34A) formed on the base material (42), the cross-linking agent (34A) being formed on the synthetic polymer film (34A) when viewed from the normal direction of the synthetic polymer film (34A); a plurality of protrusions (34Ap) having an area circle equivalent diameter in the range of greater than 20 nm and less than 500 nm; and irradiating the plurality of protrusions of the laminate with light emitted from the xenon lamp such that the irradiation amount of light in the wavelength range of 300 nm to 400 nm is 6 MJ / m2 or more.

Description

Technical Field

[0001] The present invention relates to a laminate having a synthetic polymer film with antibacterial and / or antiviral properties and a method for manufacturing the same. Background Art

[0002] The present applicant has, for example, disclosed in Patent Documents 1 to 4 a synthetic polymer film having a moth-eye structure on the surface and a surface having a bactericidal action. In addition, the term "synthetic polymer film" is used to distinguish from natural products (lipid membranes) such as cicada wings and dragonfly wings having a nano surface structure. The entire disclosures of Patent Documents 1 to 4 are incorporated herein by reference. Prior Art Documents Patent Documents

[0003] Patent Document 1: International Publication No. 2015 / 163018 Patent Document 2: International Publication No. 2016 / 080245 Patent Document 3: International Publication No. 2016 / 208540 Patent Document 4: Japanese Patent Application Laid-Open No. 2019-051638 Summary of the Invention Technical Problem to be Solved by the Invention

[0004] An object of the present invention is to further improve the bactericidal action of a synthetic polymer film. In addition, here, the object is to improve the antibacterial property evaluated by the method according to JIS Z2801 standard and / or the antiviral property evaluated by the method according to ISO 21702:2019. Solution to the Problem

[0005] According to an embodiment of the present invention, there is provided a solution described in the following items. [Item 1] A manufacturing method, which is a manufacturing method of a laminate having a synthetic polymer film with antibacterial and / or antiviral properties, the manufacturing method including: preparing a laminate having a substrate and a synthetic polymer film formed on the substrate, the synthetic polymer film having a plurality of convex portions on the surface, and when observed from the normal direction of the synthetic polymer film, the area circle equivalent diameter of the plurality of convex portions is in the range of greater than 20 nm and less than 500 nm; and irradiating the plurality of convex portions of the laminate with the emitted light of a xenon lamp such that the irradiation light amount of light in the wavelength range of 300 nm or more and 400 nm or less is 6 MJ / m 2 or more. [Item 2] The emitted light of the xenon lamp irradiated in the manufacturing method according to Item 1 means: irradiating the emitted light of the xenon lamp in such a manner that the irradiation light amount of light in the wavelength range of 300 nm or more and 400 nm or less is 22 MJ / m 2 or less. [Item 3] The emitted light of the xenon lamp irradiated in the manufacturing method according to Item 1 or 2 is performed in an environment with a relative humidity of 50% or less. [Item 4] The emitted light of the xenon lamp irradiated in the manufacturing method according to any one of Items 1 to 3 is performed while continuously blowing air to the surface of the synthetic polymer film. [Item 5] In the manufacturing method according to any one of Items 1 to 4, the synthetic polymer film is formed of an ultraviolet curable resin. [Item 6] The manufacturing method according to Item 5 includes: before irradiating the emitted light of the xenon lamp, irradiating the ultraviolet curable resin with ultraviolet rays, thereby forming the synthetic polymer film from the ultraviolet curable resin. [Item 7] In the manufacturing method according to any one of Items 1 to 6, the plurality of convex portions include substantially conical convex portions having a bottom diameter greater than 20 nm and less than 500 nm. [Item 8] In the manufacturing method according to Item 7, the substantially conical convex portion includes a convex portion having a height of 2 times or more the diameter of the bottom surface. [Item 9] A laminate includes a synthetic polymer film having antibacterial and / or antiviral properties and is manufactured by the manufacturing method according to any one of Items 1 to 8. [Item 10] In the laminate according to Item 9, the synthetic polymer film has a plurality of convex portions on the surface, and when viewed from the normal direction of the synthetic polymer film, the area circle equivalent diameter of the plurality of convex portions is in the range of greater than 20 nm and less than 500 nm, and the plurality of convex portions include convex portions having a maximum length of the bottom surface greater than 2 times the height. Advantages of the Invention

[0006] According to an embodiment of the present invention, there is provided a laminate including a synthetic polymer film having excellent antibacterial and / or antiviral properties and a manufacturing method thereof. Description of the Drawings

[0007] Figure 1A is a schematic cross-sectional view of a laminate 50A including a synthetic polymer film 34A having a moth-eye structure. Figure 1B is a schematic top view showing the convex portions 34Ap observed from the normal direction of the synthetic polymer film 34A. Figure 2Ais a schematic cross-sectional view of the laminate 50B, which includes a synthetic polymer film 34B that has been irradiated with the emitted light of a xenon lamp by the synthetic polymer film 34A. Figure 2B is a schematic plan view showing the convex portion 34Bp as viewed from the normal direction of the synthetic polymer film 34B. Figure 3 is a diagram showing the surface SEM image of the synthetic polymer film having an anti-reflection structure. Figure 4 is a diagram showing Figure 3 the surface SEM image of the synthetic polymer film after irradiating the synthetic polymer film having the anti-reflection structure shown with the emitted light of a xenon lamp. Figure 5 is a graph showing the time change of pH caused by the presence or absence of xenon lamp irradiation. Figure 6 is a graph showing the change in antibacterial property caused by xenon lamp irradiation. Figure 7 is a graph showing the change in antiviral property (influenza virus A) caused by xenon lamp irradiation. Figure 8 is a graph showing the change in antiviral property (feline calicivirus) caused by xenon lamp irradiation. Figure 9 is a diagram showing the mechanism of auto-oxidation of the synthetic polymer. Detailed Embodiments

[0008] Hereinafter, a laminate including a synthetic polymer film having antibacterial and / or antiviral properties and a method for manufacturing the same according to an embodiment of the present invention will be described with reference to the drawings. The laminate including a synthetic polymer film having antibacterial and / or antiviral properties and a method for manufacturing the same according to an embodiment of the present invention are not limited to the content exemplified below. Here, having antibacterial property means that the antibacterial activity value obtained by the test method based on JIS Z2801 standard is 2.0 or more, and having antiviral property means that the antiviral activity value obtained by the test method based on ISO 21702:2019 is 2.0 or more.

[0009] The present applicant has developed a method for manufacturing an antireflection film (antireflection surface) having a moth-eye structure using an anodized porous alumina layer. By using the anodized porous alumina layer, a mold having an inverted moth-eye structure can be manufactured with high mass productivity (Japanese Patent Laid-Open No. 2009-166502, International Publication No. 2011 / 125486, International Publication No. 2013 / 183576). A synthetic polymer film having a moth-eye structure described in Patent Documents 1 to 4 on the surface and having a surface with a bactericidal action can be manufactured by applying this technology. The entire disclosures of Japanese Patent Laid-Open No. 2009-166502, International Publication No. 2011 / 125486, and International Publication No. 2013 / 183576 are incorporated herein by reference.

[0010] A method for manufacturing a laminate including a synthetic polymer film having antibacterial and / or antiviral properties includes: a step of preparing a laminate having a substrate and a synthetic polymer film formed on the substrate, the synthetic polymer film having a plurality of convex portions on the surface thereof, the area equivalent circle diameter of which is in the range of more than 20 nm and less than 500 nm when observed from the normal direction of the synthetic polymer film; and a step of irradiating the plurality of convex portions of the laminate with the emitted light of a xenon lamp so that the irradiation light amount of light in the wavelength range of 300 nm or more and 400 nm or less is 6 MJ / m 2 or more. If the above irradiation light amount is not 6 MJ / m 2 or more, sometimes the effect of improving antibacterial and / or antiviral properties cannot be obtained sufficiently. For example, sometimes the pH value cannot be made 5.0 or less.

[0011] First, with reference to Figure 1A and Figure 1B , a laminate 50A will be described, which laminate 50A has a substrate 42 and a synthetic polymer film 34A formed on the substrate 42, the synthetic polymer film 34A having a plurality of convex portions 34Ap on the surface thereof, the area equivalent circle diameter of which is in the range of more than 20 nm and less than 500 nm when observed from the normal direction of the synthetic polymer film 34A.

[0012] Figure 1A The laminate 50A shown, for example, has a substrate 42 and a synthetic polymer film 34A formed on the substrate 42. The synthetic polymer film 34A has a plurality of convex portions 34Ap on the surface, and the plurality of convex portions 34Ap constitute a moth-eye structure. When observed from the normal direction of the synthetic polymer film 34A, the two-dimensional size Dp of the convex portion 34Ap is in the range of more than 20 nm and less than 500 nm. Here, the "two-dimensional size" of the convex portion 34Ap refers to the area equivalent circle diameter of the convex portion 34Ap when observed from the normal direction of the surface. For example, when the convex portion 34Ap is conical, as Figure 1BAs shown, the two-dimensional size of the convex portion 34Ap corresponds to the diameter of the base of a cone. Additionally, the typical adjacent distance Dint of the convex portion 34Ap is greater than 20 nm and 1000 nm or less. As Figure 1A illustrated, when the convex portions 34Ap are closely arranged and there is no gap between adjacent convex portions 34Ap (for example, the base portions of the cones overlap), the two-dimensional size Dp of the convex portion 34Ap is equal to the adjacent distance Dint.

[0013] The typical height Dh of the convex portion 34Ap is 50 nm or more and less than 500 nm. The height Dh of the convex portion 34Ap can also be 200 nm or less. The plurality of convex portions 34Ap includes, for example, substantially conical convex portions with a base diameter greater than 20 nm and less than 500 nm, and the substantially conical convex portions include convex portions with a height of at least twice the base diameter. The substantially conical convex portions with a height of at least twice the base diameter account for, for example, 60% or more of the entire convex portion. In addition, the plurality of convex portions 34Ap may not include substantially conical convex portions with a height of at least twice the base diameter. Further, in the present embodiment, the plurality of convex portions 34Ap does not include convex portions included in the plurality of convex portions 34Bp described later, where the maximum length of the base is greater than twice the height. The thickness ts of the synthetic polymer film 34A is not particularly limited as long as it is greater than the height Dh of the convex portion 34Ap.

[0014] In addition, in this specification, the "moth-eye structure" is not only a nano surface structure with excellent antireflection function composed of convex portions with a shape whose cross-sectional area (cross-section parallel to the film surface) increases as it approaches the substrate 42, such as the convex portions 34Ap of the synthetic polymer film 34A as Figure 1A shown, but also includes a nano surface structure composed of convex portions with a certain part of the cross-sectional area (cross-section parallel to the film surface). In addition, in order to break the cell wall and / or cell membrane of bacteria, a conical portion is preferably provided. However, the tip of the cone may have a circular arc.

[0015] The synthetic polymer film 34A having a moth-eye structure can be manufactured using a mold having the above-mentioned inverted moth-eye structure. Preferably, the synthetic polymer film 34A is manufactured using an ultraviolet curable resin. The ultraviolet curable resin is cured by irradiating ultraviolet light of a so-called "type D lamp" (280 nm to 400 nm, peak wavelength 380 nm). As the ultraviolet curable resin, various known ultraviolet curable resins (such as acrylic resins) can be used. Sometimes, a resin cured by irradiating ultraviolet light to an ultraviolet curable (UV curable) resin is called an ultraviolet cured (UV cured) resin. As the substrate 42, various plastic films (such as polystyrene, polyurethane, aromatic polyamide, polyester, polycarbonate) can be used, for example. Polycarbonate (PC) with excellent light resistance and oxidation resistance is preferred.

[0016] The present inventors have found that by irradiating the plurality of convex portions 34Ap of the above laminate with the emitted light of a xenon lamp, the irradiation light amount of light in the wavelength range of 300 nm or more and 400 nm or less reaches 6 MJ / m 2 or more, thereby improving the antibacterial property and / or antiviral property. There is no particular upper limit for the irradiation light amount, but even if it is greater than 22 MJ / m 2 , the antibacterial property and / or antiviral property will not be improved. From the viewpoint of mass productivity, the irradiation light amount is 22 MJ / m 2 or less. In addition, if the above irradiation light amount is greater than 22 MJ / m 2 , the synthetic polymer film sometimes turns yellow. For example, when the intensity of light in the wavelength range of 300 nm or more and 400 nm or less is 60 W / m 2 , it is sufficient to irradiate for 30 hours to 100 hours. For example, by using a xenon arc lamp (xenon hygrometer XL75 manufactured by Suga Test Instruments Co., Ltd.), irradiation can be performed from a position 290 mm away from the synthetic polymer film 34A, and light with an intensity of about 60 W / m 2 in the wavelength range of 300 nm or more and 400 nm or less can be irradiated.

[0017] When irradiating a synthetic polymer film (preferably an ultraviolet curable resin) with light in the wavelength range of 300 nm or more and 400 nm or less, the chemical bonds constituting the synthetic polymer film are broken, and well-known auto-oxidation occurs. The free radicals and intermediate products generated by the photochemical reaction are further auto-oxidized, and free radicals and acids are generated. The mechanism of auto-oxidation is, for example, as Figure 9 shown. The generated free radicals, etc. attack the proteins on the surface of bacteria and / or viruses, extract hydrogen, and decompose the proteins. Alternatively, the acids generated by the photochemical reaction can make it difficult for bacteria and / or viruses to survive. In addition, organic components having aldehyde-based, carboxylic acid-based, and ester-based chemical structures can damage proteins such as DNA, RNA, and enzymes, and ultraviolet curable resin films and substrates that generate them by photochemical reactions can also be used.

[0018] In addition, the step of irradiating the emitted light of the xenon lamp is preferably performed in an environment with a relative humidity of 50% or less. This is because hydrolysis may occur depending on the ultraviolet curable resin. In addition, the step of irradiating the emitted light of the xenon lamp is preferably performed while continuously blowing air to the surface of the synthetic polymer film 34A. During this time, the synthetic polymer film 34A is preferably placed in an environment of about 50 °C or less.

[0019] Next, with reference to Figure 2A 、 Figure 2B , the structure of the laminate 50B having the synthetic polymer film 34B irradiated with the emitted light of the xenon lamp will be described.Figure 2A It is a schematic cross-sectional view of a laminate 50B of a synthetic polymer film 34B that emits the emitted light of a xenon lamp onto the synthetic polymer film 34A. Figure 2B It is a schematic plan view showing the convex portions 34Bp as viewed from the normal direction of the synthetic polymer film 34B.

[0020] As Figure 2A shown, the plurality of convex portions 34Bp of the synthetic polymer film 34B are Figure 1A the result of decomposing the plurality of convex portions 34Ap of the synthetic polymer film 34A shown, the height Dh becomes lower, and in addition, the top of the substantially conical convex portion has an arc. Convex portions with a flat top may also be formed. In addition, the bottom of the concave portion between adjacent convex portions 34Bp also has an arc. A concave portion with a flat bottom may also be formed between adjacent convex portions 34Bp. The deviation in the shape and size of the plurality of convex portions 34Bp becomes larger. The plurality of convex portions 34Bp include convex portions in which the maximum length of the bottom surface (here Dx) is greater than twice the height Dh. In addition, the plurality of convex portions 34Bp may also include convex portions in which the maximum length of the bottom surface is three times or more the height Dh. The plurality of convex portions 34Bp may or may not include substantially conical convex portions having a height of twice or more the bottom diameter included in the plurality of convex portions 34Ap. In addition, the maximum length of the bottom surface of the convex portion is the maximum value of the distance between two points on the outer periphery of the bottom surface of each convex portion.

[0021] In addition, as Figure 2B shown, when viewed from the normal direction of the synthetic polymer film 34B, the maximum length of the bottom surface of the convex portion 34Bp (here Dx) is substantially equal to the minimum length of the bottom surface (here the length Dy in the direction orthogonal to Dx), and Dx / Dy is less than 2.0. The shape of the bottom surface of the convex portion 34Bp is substantially circular.

[0022] Refer to Figure 3 and Figure 4 to describe the experimental examples.

[0023] A synthetic polymer film with a moth-eye structure was formed on a polycarbonate-based film. Polyethylene glycol diacrylate (M280: manufactured by MIWON SPECIALTY CHEMICAL CO., LTD), trimethylolpropane triacrylate (M300: manufactured by MIWON SPECIALTY CHEMICAL CO., LTD), 2-(2-vinyloxyethoxy)ethyl acrylate (VEEA: manufactured by Nippon Catalyst Co., Ltd.), and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Omnirad 2959: manufactured by IGM Resins B.V.) as a polymerization initiator material were used. Based on mass, a resin material (solvent-free) with a ratio of m280:m300:VEEA:Omnirad = 55:10:35:1 was coated on the polycarbonate-based film to a desired thickness, and then irradiated with a D-type lamp (320 - 400 nm, 1200 W / m 2 ) for about 15 seconds (22500 J / m 2 ). The moth-eye structure was set to Dp = Dint = 200 nm and Dh = 200 nm.

[0024] Figure 3 The surface SEM image of the synthetic polymer film with a moth-eye structure is shown. It can be seen that a plurality of substantially conical protrusions are closely formed. Figure 3 The plurality of protrusions on the surface of the shown synthetic polymer film have the characteristics of the plurality of protrusions 34Ap described with reference to Figure 1A , and include substantially conical protrusions with a height of more than twice the base diameter. Substantially conical protrusions with a height of more than twice the base diameter, for example, account for more than 60% of the overall protrusions. There are also substantially conical protrusions with a height less than twice the base diameter.

[0025] Figure 4 The surface SEM image of the synthetic polymer film after irradiating the synthetic polymer film with the above-described moth-eye structure with the emitted light (60 W / m 2 ) of a xenon lamp for 100 hours (about 22 MJ / m 2 ) is shown. Figure 3The convex portions of the moth-eye structure seen in [reference] have their height reduced through decomposition. Although there are also convex portions that are roughly conical, most of the tops of the convex portions are rounded. In addition, convex portions with flat tops are also formed. The bottoms of the concave portions between adjacent convex portions are also rounded, and concave portions with flat bottoms are also formed between adjacent convex portions. The deviation in the shape and size of the multiple convex portions becomes larger. Although convex portions can be seen where the maximum length of the bottom (here, it is roughly in the horizontal direction and is sometimes referred to as the "width") is more than twice the height, generally speaking, the width of the convex portions is 1 to 2 times the height, and there are more convex portions where the width is 1.0 to 1.5 times the height. However, the multiple convex portions can also include convex portions where the maximum length of the bottom surface is more than 3 times the height (for example, Figure 4 the convex portion near the center in [reference].

[0026] Next, refer to Figure 5 . Figure 5 is a graph showing the time change of pH caused by the presence or absence of xenon lamp irradiation. That is, this is an evaluation of how the surface of the synthetic polymer film with a moth-eye structure chemically changes under xenon lamp irradiation based on the time change of pH. The horizontal axis of the graph represents the test solution contact time. The sample used was the same synthetic polymer film as Figure 4 . The pH was measured using a method equivalent to the antiviral test. Specifically, it was measured as follows.

[0027] On the moth-eye structure surface of the sample placed in a petri dish, 0.1 ml of EMEM dilution solution (a solution obtained by diluting EMEM 10 times with sterilized distilled water) was dropped in the same way as the virus suspension, and then a sealing film (polyethylene film) was covered and gently pressed to spread the dilution solution over the entire film. In this state, the petri dish was covered and left at 25 °C for 24 h. Then, the sealing film was removed, and the pH of the test solution on the surface of the sample was measured using a flat-end type (flat) ISFET pH electrode manufactured by Horiba, Ltd.

[0028] As Figure 5 shows, when the test solution contact time is 0 h, the pH value (5.68) of the synthetic polymer film irradiated with the xenon lamp is less than the pH value (8.05) of the synthetic polymer film not irradiated with the xenon lamp and is in the acidic region. This can be considered because through xenon lamp irradiation, a photochemical reaction occurred on the surface of the synthetic polymer film, generating acid components. When the test solution contact time is 24 h, the pH value (8.09) of the synthetic polymer film not irradiated with the xenon lamp hardly changes. In contrast, the pH value (3.60) of the synthetic polymer film irradiated with the xenon lamp further decreases. This is considered that on the surface of the synthetic polymer film irradiated with the xenon lamp, free radicals and intermediate products generated in the resin through photochemical reactions undergo an auto-oxidation reaction.

[0029] Figure 6 The results of evaluating antibacterial properties according to the method of JIS Z2801 (ISO 22196) are shown. Bacterial suspensions were inoculated onto specimens irradiated with a xenon lamp and specimens not irradiated with a xenon lamp, respectively. After allowing the specimens to come into contact with bacteria for 24 hours, the number of bacteria on the specimens was measured using the plaque measurement method. By comparing the amounts of bacteria on the specimens irradiated with a xenon lamp and those not irradiated with a xenon lamp, the antibacterial activity value was calculated.

[0030] As the bacterial species, Staphylococcus aureus ( Figure 6 single-dashed line and solid line in Figure 6 ) and Escherichia coli ( double-dashed line and dotted line in ) were used. For these bacteria, no antibacterial effect was found in the moth-eye structure without xenon lamp irradiation. In contrast, the antibacterial activity values of the synthetic polymer film with a moth-eye structure irradiated with a xenon lamp were greater than 2.0 for all bacterial species, indicating that the antibacterial property was improved by xenon lamp irradiation. In addition, the antibacterial activity value was calculated as follows. Antibacterial activity value = log (number of bacteria after 24 hours of cultivation of the unprocessed product) - log (number of bacteria after 24 hours of cultivation of the antibacterial processed product)

[0031] In addition, "-0.2" represents the detection limit.

[0032] Figure 7 and Figure 8 The results of evaluating antiviral properties according to the method of ISO 21702:2019 are shown.

[0033] As the virus species, influenza virus A (enveloped virus) ( Figure 7 ) and feline calicivirus (non-enveloped virus) ( Figure 8 ) were used.

[0034] From Figure 7 and Figure 8 it can be seen that the antiviral effect was improved by xenon lamp irradiation, and antiviral activity values greater than 2.0 were obtained for any of the viruses. In addition, the antiviral activity value was calculated as follows. Antiviral activity value = log (number of viruses after 24 hours of cultivation of the unprocessed product) - log (number of viruses after 24 hours of cultivation of the antiviral processed product) Influenza activity value ≥ 3.4 = 4.16 - 0.8 Feline calicivirus activity value ≥ 2.7 = 5.49 - 2.83

[0035] Here, an example of irradiating a synthetic polymer film having a moth-eye structure with a xenon lamp is shown. However, it is considered that if a resin material that can generate chemical reactions such as auto-oxidation and decomposition by irradiating a synthetic polymer film with a xenon lamp, even without a moth-eye structure, and thus form fine uneven structures (surface roughness) on the surface, the antibacterial and / or antiviral properties can be improved. The irradiation conditions of the xenon lamp can be the same as those of the illustrated synthetic polymer film having a moth-eye structure. Industrial Applicability

[0036] According to the manufacturing method of a laminate including a synthetic polymer film having antibacterial and / or antiviral properties according to an embodiment of the present invention, a laminate having improved antibacterial and / or antiviral properties compared to the prior art can be provided. According to an embodiment of the present invention, a laminate including a synthetic polymer film having antiviral properties against both enveloped viruses and non-enveloped viruses can be provided. Description of Reference Numerals

[0037] 34A, 34B Synthetic polymer film 34Ap, 34Bp Protrusion 42 Substrate 50A, 50B Laminate

Claims

1. A method for producing a laminate, wherein the laminate comprises a synthetic polymer film having antibacterial and / or antiviral properties, the method comprising: Preparing a laminated body comprising a substrate and a synthetic polymer film formed on the substrate, wherein the synthetic polymer film has a plurality of protrusions on a surface, and when observed from a normal direction of the synthetic polymer film, the area circle equivalent diameter of the plurality of protrusions is within a range of greater than 20 nm and less than 500 nm; and The plurality of convex portions of the stacked body are irradiated with light having a wavelength range of 300 nm to 400 nm at a light intensity of 6 MJ / m 2 The output light of the xenon lamp is irradiated in the above manner.

2. The manufacturing method according to claim 1, characterized in that: The xenon lamp is irradiated with light emitted from the lamp so that the irradiation light amount of light in the wavelength range of 300 nm to 400 nm is 22 MJ / m 2 The emitted light of the xenon lamp was irradiated in the following manner.

3. The manufacturing method according to claim 1 or 2, characterized in that: The irradiation with the emitted light of the xenon lamp is performed in an environment with a relative humidity of 50% or less.

4. The manufacturing method according to claim 1 or 2, characterized in that: The irradiation of the emitted light of the xenon lamp is performed while continuously sending air to the surface of the synthetic polymer film.

5. The manufacturing method according to claim 1 or 2, characterized in that: The synthetic polymer film is formed of ultraviolet curable resin.

6. The manufacturing method according to claim 5, characterized in that: include: The synthetic polymer film is formed by irradiating the ultraviolet curable resin with ultraviolet rays before irradiating the emitted light of the xenon lamp.

7. The manufacturing method according to claim 1 or 2, characterized in that: The plurality of convex portions include a substantially conical convex portion having a bottom surface diameter greater than 20 nm and less than 500 nm.

8. The manufacturing method according to claim 7, characterized in that: The substantially conical convex portion includes a convex portion having a height that is at least twice the diameter of the bottom surface.

9. A laminated body, characterized in that: A synthetic polymer film having antibacterial and / or antiviral properties, and produced by the production method according to any one of claims 1 to 8.

10. The laminate according to claim 9, characterized in that The synthetic polymer film has a plurality of convex portions on the surface, and when observed from the normal direction of the synthetic polymer film, the area circle equivalent diameter of the plurality of convex portions is within a range of greater than 20 nm and less than 500 nm, The plurality of protrusions include a protrusion whose maximum length of a bottom surface is greater than twice its height.

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