Antidiarrheal pharmaceutical composition for infantile cold-dampness diarrhea, navel patch and preparation method of navel patch

Abstract

The invention provides an antidiarrheal pharmaceutical composition for infantile cold-dampness diarrhea, an antidiarrheal navel patch for infantile cold-dampness diarrhea and a preparation method of the antidiarrheal navel patch. The antidiarrheal pharmaceutical composition for infantile cold-dampness diarrhea comprises the following components: 5-12 parts of white pepper, 3-8 parts of cinnamon, 3-8 parts of fructus evodiae, 7-14 parts of gallnut, 5-12 parts of bighead atractylodes rhizome, 5-12 parts of poria cocos, 3-8 parts of dried ginger and 2-4 parts of liquorice. The preparation method of the antidiarrheal navel patch for children's cold-dampness diarrhea comprises the following steps: mixing the pharmaceutical composition with auxiliary materials to obtain a functional dressing; in a sterile environment, the functional dressing is made into powder with uniform and fine texture, the space between the middle layer and the breathable layer of the prepared adhesive patch is filled with the powder, and the navel patch is obtained. The pharmaceutical composition provided by the invention can quickly relieve diarrhea and pain and also can improve spleen and stomach functions in a long-acting manner through the synergistic effect of certain drug component proportions; the medicine is administrated in the form of navel paste, is relatively light in burden on internal organs of children, is more easily accepted by children patients, and also has the effects of catalyzing the medicine property and applying hot compress to affected parts.

Description

Technical Field

[0001] The present invention relates to the field of medicine, and particularly to an antidiarrheal pharmaceutical composition for children with cold-damp diarrhea, an umbilical patch and a preparation method thereof. Background Art

[0002] Diarrhea in children is a common digestive system disease in children, usually caused by factors such as viral or bacterial infections or food intolerance. Existing Western medical treatment methods mainly include oral rehydration, antibiotics and other drugs.

[0003] Although oral medications, antibiotic injections, etc. can effectively relieve symptoms, first, since the body organs, immune system, etc. of children are not yet fully developed, the absorption and metabolism of drugs may be affected, resulting in poor efficacy; second, long-term use of antibiotic drugs is likely to affect the immune system of children and reduce their resistance; third, many drugs may cause burdens and side effects on the digestive tract, liver and kidneys of children during treatment, affecting the health of children; fourth, most current oral medications do not fully consider the usage habits and psychological needs of children, and some children have a low acceptance of oral medications, and parents often face difficulties in administering medications; these problems all lead to concerns of parents about the use of drugs. Summary of the Invention

[0004] In order to solve the above problems, the present invention provides an antidiarrheal pharmaceutical composition for children with cold-damp diarrhea, an umbilical patch for antidiarrheal treatment of children with cold-damp diarrhea and a preparation method thereof. By adopting the method of external umbilical patch, it can effectively reduce the direct impact of drugs on internal organs, thereby reducing the risk of side effects, and is more acceptable to pediatric patients; and the present invention synergistically takes effect through the combination ratio of multiple specific components, which can not only quickly relieve pain and stop diarrhea, but also long-term improve the spleen and stomach function.

[0005] The technical solution adopted by the present invention is as follows:

[0006] In a first aspect, the present invention provides an antidiarrheal pharmaceutical composition for children with cold-damp diarrhea, which comprises the following components in parts by mass:

[0007] 5-12 parts of white pepper, 3-8 parts of cinnamon, 3-8 parts of evodia rutaecarpa, 7-14 parts of Chinese gallnut, 5-12 parts of atractylodes macrocephala, 5-12 parts of poria cocos, 3-8 parts of dried ginger, and 2-4 parts of licorice.

[0008] In a possible implementation manner, at least part of the components are processed by roasting, and the specific operations of the roasting include:

[0009] The white pepper is stir-fried over a slow fire until slightly yellow and with a slight aroma, and then taken out and cooled;

[0010] The outer bark of the cinnamon is scraped off;

[0011] The evodia rutaecarpa is stir-fried with salt water until it emits an aroma;

[0012] Atractylodes macrocephala Koidz is stir-fried with bran until slightly yellowish.

[0013] Dry ginger is heated over a fire until smoke rises.

[0014] Licorice is stir-fried with honey until slightly yellowish.

[0015] In a second aspect, the present invention provides an umbilical patch for relieving diarrhea of children with cold-dampness type, comprising an adhesive patch and an efficacy dressing component.

[0016] The efficacy dressing component comprises the following components:

[0017] An appropriate amount of the above-mentioned pharmaceutical composition;

[0018] Auxiliary materials, the auxiliary materials include 9-21 parts of iron powder, 3-7 parts of sodium chloride, and 3-7 parts of vermiculite.

[0019] The adhesive patch is a multi-layer film structure, which sequentially comprises an adhesive layer, an intermediate layer and a breathable layer from bottom to top;

[0020] Cavities are formed between the intermediate layer and the adhesive layer, and between the intermediate layer and the breathable layer. The pharmaceutical composition is filled in the cavity between the adhesive layer and the intermediate layer, and the auxiliary materials are filled in the cavity between the breathable layer and the intermediate layer;

[0021] A plurality of breathable micropores are distributed on the breathable layer.

[0022] In a possible implementation manner,

[0023] The components of the auxiliary materials further include 6-14 parts of activated carbon.

[0024] In a third aspect, the present invention provides a preparation method of an umbilical patch for relieving diarrhea of children with cold-dampness type, comprising the following steps:

[0025] S1. Weigh 5-12 parts of raw material white pepper, 3-8 parts of cinnamon, 3-8 parts of evodia rutaecarpa, 7-14 parts of gallnut, 5-12 parts of atractylodes macrocephala Koidz, 5-12 parts of poria cocos, 3-8 parts of dry ginger, and 2-4 parts of licorice;

[0026] S2. Pretreat the raw materials weighed in S1, including the following operations:

[0027] White pepper is stir-fried with slow fire until slightly yellowish and slightly fragrant, and then taken out and cooled;

[0028] The outer skin of cinnamon is scraped off;

[0029] Evodia rutaecarpa is stir-fried with salt water until fragrant;

[0030] Atractylodes macrocephala Koidz is stir-fried with bran until slightly yellowish; Dry ginger is heated over a fire until smoke rises.

[0031] For the licorice, use the honey-baking method to stir-fry the licorice and honey together until slightly yellowish.

[0032] S3. Grind each of the pretreated raw materials into fine powder respectively; then add an appropriate amount of rice vinegar or ginger juice and mix into a medicinal paste. The dosage of the rice vinegar or ginger juice should be such that the medicinal paste can form a ball and does not drip.

[0033] S4. Weigh 9 - 21 parts of iron powder as the auxiliary raw material, 6 - 14 parts of activated carbon, 3 - 7 parts of sodium chloride, and 3 - 7 parts of vermiculite.

[0034] S5. Mix the auxiliary raw materials weighed in S4 evenly to obtain an auxiliary composition.

[0035] S6. Coat a waterborne polyurethane emulsion on the silicon-coated surface of the PET release film. After drying to form a film, then coat a waterborne medical pressure-sensitive adhesive emulsion, and obtain an adhesive layer after drying.

[0036] S7. Place the medicinal paste obtained in S3 on the side of the adhesive layer obtained in S6 coated with the waterborne medical pressure-sensitive adhesive emulsion. Then take a non-woven fabric as the intermediate layer, and bond and fix the edge of the intermediate layer to the edge of this side of the adhesive layer.

[0037] S8. Place the auxiliary composition obtained in S5 on the side of the intermediate layer not bonded and fixed to the adhesive layer. Then take a microporous breathable film as the breathable layer, and bond and fix the edge of the breathable layer to the edge of this side of the intermediate layer, thus obtaining the anti-diarrhea umbilical patch for children with cold-damp diarrhea; put the anti-diarrhea umbilical patch for children with cold-damp diarrhea into an airtight outer bag and store it sealed.

[0038] The above technical solution provided by this application has at least the following technical effects or advantages:

[0039] (1) The anti-diarrhea drug composition for children with cold-damp diarrhea provided by this application, through a carefully designed combination of traditional Chinese medicine ingredients, forms a plaster formula with multiple effects such as warming the middle-jiao to dispel cold, strengthening the spleen to promote diuresis, and astringing diarrhea. It can not only quickly relieve pain and stop diarrhea, but also long-term warm and nourish the spleen and stomach, and improve the digestive tract function.

[0040] (2) The anti-diarrhea drug composition for children with cold-damp diarrhea provided by this application, through a carefully designed combination of traditional Chinese medicine ingredients, the components cooperate with each other synergistically to ensure the effectiveness and stability in relieving diarrhea symptoms.

[0041] (3) The anti-diarrhea umbilical patch for children with cold-damp diarrhea provided by this application, through the form of external application, can effectively reduce the direct impact of the drug on internal organs, thereby reducing the risk of side effects.

[0042] (4) The anti - diarrhea umbilical patch for children with cold - damp diarrhea provided by this application takes into account the common situation of children's refusal to take medicine. By using the umbilical patch form for drug administration, it not only eliminates the need for oral administration or injection, reducing children's resistance psychology, but also the umbilical patch form is more interesting for child patients. At the same time, it meets the drug administration needs and psychological needs of child patients, providing a more convenient and acceptable treatment method, and also reducing the medication anxiety of parents of children.

[0043] (5) This application solves the problem of insufficient hygiene standards of existing umbilical patches. The preparation methods and hygiene standards of existing products are not strict enough. The skin barrier at the navel of children is relatively weak, dark and humid. Using umbilical patch products with lower hygiene standards may lead to bacterial infections during use, etc. However, this application ensures the safety and hygiene of the umbilical patch and reduces the infection risk by improving the preparation process and material selection.

[0044] (6) The anti - diarrhea umbilical patch for children with cold - damp diarrhea provided by this application starts from multiple aspects such as treatment effect, treatment method, drug administration safety, acceptance degree of child patients, and health degree of drug administration hygiene. Overall, it meets the market demand for children's diarrhea treatment products and has good market prospects and competitiveness. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] In order to more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the following will briefly introduce the drawings required for the description of the embodiments of this application or the prior art. Obviously, the drawings in the following description are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0046] Figure 1 It is an exploded view of the structure of the anti - diarrhea umbilical patch for children with cold - damp diarrhea prepared in Example 1 of this application;

[0047] Figure 2 It is a sectional view of the structure of the anti - diarrhea umbilical patch for children with cold - damp diarrhea prepared in Example 1 of this application.

[0048] In the figure: 1 - breathable layer; 2 - intermediate layer; 3 - adhesive layer; 4 - auxiliary composition; 5 - drug composition. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0049] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of them. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

[0050] Example 1

[0051] This example provides an antidiarrheal pharmaceutical composition for children with cold-damp diarrhea, which comprises the following components in parts by mass:

[0052] 5 g of white pepper, 3 g of cinnamon, 3 g of evodia rutaecarpa, 7 g of Chinese gallnut, 5 g of atractylodes macrocephala, 5 g of poria cocos, 3 g of dried ginger, and 2 g of liquorice.

[0053] The pharmaceutical composition provided in this example selects traditional Chinese medicine components such as white pepper, cinnamon, evodia rutaecarpa, Chinese gallnut, atractylodes macrocephala, poria cocos, dried ginger, and liquorice to form a patch formula with multiple effects such as warming the middle-jiao to dispel cold, strengthening the spleen to promote diuresis, and astringing diarrhea, so as to enhance the therapeutic effect of the umbilical patch. In its formula:

[0054] The main functions of white pepper are: warming the middle-jiao to dispel cold, tonifying the spleen and stomach, and enhancing digestive function;

[0055] The main functions of cinnamon are: dispelling cold and relieving pain, tonifying fire and assisting yang, and improving abdominal pain symptoms;

[0056] The main functions of evodia rutaecarpa are: warming the middle-jiao to dispel cold, soothing the liver and relieving depression, and relieving diarrhea caused by emotions;

[0057] The main functions of Chinese gallnut are: astringing diarrhea and enhancing the resistance of the intestine;

[0058] The main functions of atractylodes macrocephala are: strengthening the spleen to promote diuresis, improving dyspepsia, and enhancing the function of the spleen and stomach;

[0059] The main functions of poria cocos are: strengthening the spleen to promote diuresis, regulating the spleen and stomach, and promoting water metabolism;

[0060] The main functions of dried ginger are: warming the middle-jiao to dispel cold, restoring yang and rescuing from collapse, and enhancing the body's cold resistance.

[0061] In addition to utilizing the efficacy and functions of these Chinese medicinal materials themselves, more importantly, through formulation, various synergistic effects are generated among the various medicinal materials, such as:

[0062] 1. Synergistic effect of warming the middle-jiao to dispel cold

[0063] White pepper, cinnamon, evodia rutaecarpa, and dried ginger all have the efficacy of warming the middle-jiao to dispel cold. White pepper warms the middle-jiao to dispel cold and enhances digestive function; cinnamon dispels cold and relieves pain, tonifies fire and assists yang; dried ginger warms the middle-jiao to dispel cold, restores yang and rescuing from collapse. The combined action of these medicines can more comprehensively dispel the cold pathogen in the body and relieve symptoms such as abdominal pain and diarrhea caused by the cold pathogen.

[0064] Synergistic advantage: The combination of various drugs for warming the middle-jiao and dispelling cold can not only enhance the effect of warming yang and dispelling cold, but also target the cold pathogens in different parts for targeted treatment. For example, cinnamon focuses on warming the kidney yang, dried ginger focuses on warming the middle-jiao and restoring yang, and white pepper is more focused on warming the stomach and dispelling cold. This multi-level warming effect can more effectively improve the symptoms of spleen and stomach deficiency-cold.

[0065] 2. Synergistic effect of strengthening the spleen and promoting diuresis and enhancing the function of the spleen and stomach

[0066] Both Atractylodes macrocephala and Poria cocos have the effects of strengthening the spleen and promoting diuresis. Atractylodes macrocephala strengthens the spleen and promotes diuresis, improves dyspepsia, and enhances the function of the spleen and stomach; Poria cocos strengthens the spleen and promotes diuresis, regulates the spleen and stomach, and promotes water metabolism. The combination of the two can better regulate the transportation and transformation function of the spleen and stomach, and improve symptoms such as dyspepsia and abdominal distension caused by the retention of dampness pathogen.

[0067] Synergistic advantage: Atractylodes macrocephala focuses on strengthening the spleen and replenishing qi, while Poria cocos focuses on promoting diuresis and percolating dampness. The combination of the two can not only enhance the transportation and transformation function of the spleen and stomach, but also regulate the body's water metabolism, achieving the dual effects of strengthening the spleen and promoting diuresis. At the same time, Atractylodes macrocephala and Poria cocos can also enhance the absorption and utilization efficiency of other drugs in the spleen and stomach, further improving the overall therapeutic effect.

[0068] 3. Synergistic effect of regulating qi and antidiarrheal

[0069] Licorice has the effects of regulating the middle-jiao and relieving spasm, warming the middle-jiao and descending qi, and can improve the qi stagnation in the digestive tract and relieve symptoms such as abdominal distension and belching. Galla chinensis has the effect of astringing diarrhea, can enhance the resistance of the intestine, and reduce the occurrence of diarrhea.

[0070] Synergistic advantage: Licorice improves the qi movement in the intestine by warming the middle-jiao and descending qi, and reduces abdominal distension and dyspepsia caused by qi stagnation. Galla chinensis directly acts on the intestine by astringing diarrhea, reduces intestinal secretion, and enhances the absorption function of the intestine. The combination of the two can not only regulate the intestinal qi, but also stop diarrhea, achieving the effect of treating both the symptoms and the root cause.

[0071] 4. Synergistic effect of soothing the liver and relieving depression and warming the middle-jiao and dispelling cold

[0072] Evodia rutaecarpa has the effects of warming the middle-jiao and dispelling cold, soothing the liver and relieving depression, and can relieve diarrhea caused by emotions. Its effect of soothing the liver and relieving depression can regulate the liver qi and prevent the liver qi stagnation from affecting the transportation and transformation function of the spleen and stomach.

[0073] Synergistic advantage: The effect of Evodia rutaecarpa in soothing the liver and relieving depression can regulate the influence of emotions on the spleen and stomach, and prevent the disorder of the spleen and stomach function caused by emotional fluctuations. At the same time, its effect of warming the middle-jiao and dispelling cold can synergize with other yang-warming drugs to enhance the overall effect of warming the middle-jiao and dispelling cold. This dual mechanism of action can better deal with the symptoms of spleen and stomach deficiency-cold caused by emotional factors.

[0074] 5. Overall synergistic effect

[0075] This group of traditional Chinese medicine components covers various effects such as warming the middle-jiao to dispel cold, strengthening the spleen to promote diuresis, regulating qi to stop diarrhea, soothing the liver and relieving depression, etc. Through the mutual cooperation of various drugs, it can improve the symptoms of spleen and stomach deficiency-cold from multiple aspects, regulate the transportation and transformation function of the spleen and stomach, and enhance the overall cold resistance and digestion and absorption function of the body.

[0076] Synergistic advantage: This multi-faceted conditioning effect can better cope with complex symptoms and causes. For example, for patients with spleen and stomach deficiency-cold accompanied by mood swings, this combination can not only warm yang and dispel cold, but also soothe the liver and relieve depression; for patients with spleen and stomach deficiency-cold accompanied by internal retention of damp pathogens, this combination can not only strengthen the spleen to promote diuresis, but also warm the middle-jiao to dispel cold.

[0077] This comprehensive conditioning mechanism can play a synergistic effect of "1 + 1 > 2", improving the overall treatment effect.

[0078] In this embodiment, using the above-mentioned antidiarrheal drug composition for children with cold-damp diarrhea as the main active ingredient, a navel patch for treating cold-damp diarrhea in children is prepared, and its structure is as Figures 1 - 2 shown; in addition to the prepared adhesive patch and the above-mentioned drug composition, the navel patch for treating cold-damp diarrhea in children also includes an auxiliary material composition. The drug composition and the auxiliary material composition are combined to form an efficacy dressing assembly; the auxiliary material composition includes the following components in parts by mass:

[0079] 9 - 21 parts of iron powder, 6 - 14 parts of activated carbon, 3 - 7 parts of sodium chloride, 3 - 7 parts of vermiculite. The specific addition amount of the auxiliary materials is flexibly determined according to the amount of the above-mentioned antidiarrheal drug composition to be incorporated, so as to achieve a better balance of the structural stability, drug efficacy, calorific value and storage stability of the whole efficacy dressing.

[0080] The preparation method of the navel patch for treating cold-damp diarrhea in children provided by this embodiment includes the following steps:

[0081] S1. Weigh each of the above components of the drug composition in this embodiment;

[0082] S2. Pretreat the raw materials weighed in S1, including the following operations:

[0083] Stir-fry white pepper over low heat until slightly yellow and with a slight aroma, then take it out and let it cool;

[0084] Scrape off the outer bark of cinnamon;

[0085] Stir-fry evodia rutaecarpa with salt water until it gives off an aroma;

[0086] Stir-fry atractylodes macrocephala with bran until slightly yellow; heat dried ginger over fire until smoke rises;

[0087] Process licorice by honey frying method, stir-fry licorice and honey together until slightly yellow;

[0088] S3. Grind each of the pre-treated raw materials into fine powder respectively; then add an appropriate amount of rice vinegar or ginger juice to make a medicinal paste, and the amount of rice vinegar or ginger juice should be such that the medicinal paste can form a ball and does not drip.

[0089] S4. Weigh 9 - 21 parts of auxiliary material iron powder, 6 - 14 parts of activated carbon, 3 - 7 parts of sodium chloride, and 3 - 7 parts of vermiculite; the amount of the auxiliary materials is flexibly determined according to the amount of the above-mentioned pharmaceutical composition to be incorporated, so as to achieve a better balance of the overall structural stability, medicinal efficacy, calorific value, and storage stability of the efficacy dressing.

[0090] S5. Mix the auxiliary material raw materials weighed in S4 evenly to obtain auxiliary material composition 4.

[0091] S6. Coat the silicone-coated surface of the PET release film with a waterborne polyurethane emulsion, dry to form a film, and then coat with a waterborne medical pressure-sensitive adhesive emulsion, and obtain adhesive layer 3 after drying.

[0092] S7. Place the medicinal paste-like pharmaceutical composition 5 obtained in S3 at the side of adhesive layer 3 coated with the waterborne medical pressure-sensitive adhesive emulsion obtained in S6, then take non-woven fabric as intermediate layer 2, and bond and fix the edge of intermediate layer 2 with the edge of this side of adhesive layer 3.

[0093] S8. Place the auxiliary material composition 4 obtained in S5 at the side of intermediate layer 2 not bonded and fixed with adhesive layer 3, then take a microporous breathable film as breathable layer 1, and bond and fix the edge of breathable layer 1 with the edge of this side of intermediate layer 2, thus obtaining the anti-diarrhea umbilical patch for children with cold-damp diarrhea; put the anti-diarrhea umbilical patch for children with cold-damp diarrhea into an airtight outer bag and store it sealed.

[0094] The anti-diarrhea umbilical patch for children with cold-damp diarrhea prepared in this embodiment adopts an automatic heating mechanism. By mixing iron powder, activated carbon, vermiculite, and sodium chloride in a certain proportion, heat is generated through chemical reactions to maintain the umbilical patch within an appropriate temperature range, thereby promoting the penetration and absorption of drug components. This embodiment uses the umbilical patch form for drug administration, which has a relatively light burden on the internal organs of children and is more easily accepted by pediatric patients. Through the synergistic effect of a certain drug component ratio, it can not only quickly relieve diarrhea and pain but also improve the spleen and stomach function in the long term.

[0095] In the anti-diarrhea umbilical patch for children with cold-damp diarrhea provided in this embodiment, vermiculite and activated carbon play a role as carriers for carrying and adsorbing iron powder and evenly dissipating heat.

[0096] In addition, after the iron powder in the adjuvant comes into contact with the outside air, it will trigger an oxidation reaction of the iron powder. During this period, the iron powder continuously generates heat. First, it can play a hot compress role on the abdomen of pediatric patients, warming the stomach and intestines to relieve discomfort; second, it can stimulate and promote the release of drug properties, cooperate with the hot compress effect to further enhance the drug properties, and promote the penetration and absorption of drug components.

[0097] In this embodiment, activated carbon powder is added, which has long-term breathable and moisture-absorbing effects. It can timely absorb and discharge the sweat generated by the heat of the patch at the affected area, avoiding the growth of bacteria; and it can also work synergistically with sodium chloride and vermiculite to preserve moisture, facilitating the rapid and uniform transfer and volatilization of the heat generated by the oxidation of iron powder, and avoiding overheating and scalding.

[0098] This embodiment strictly requires and implements the hygiene standards in the preparation process of the navel patch, selects materials that meet the hygiene standards to ensure avoiding pollution during the production process; uses a sterile environment for the production of the navel patch to ensure the hygiene and safety of each navel patch; uses moisture-proof and pollution-proof packaging materials to ensure that it is not affected by the external environment during transportation and storage.

[0099] In addition, the pediatric cold-damp diarrhea anti-diarrhea navel patch prepared in this embodiment can not only start to generate heat immediately after preparation for immediate use. Further, with other adjuvants such as activated carbon and vermiculite as a buffer, the added iron powder will not be completely oxidized. After being stored in a sealed bag, the navel patch does not come into contact with the outside air, and the oxidation and heat generation effect of the iron powder will stop relatively quickly; when the navel patch needs to be used later, tear open the sealed bag, apply the navel patch to the affected area, the iron powder in the efficacy dressing comes into contact with the outside air again, and the oxidation reaction is quickly started again with the help of the residual moisture in the dressing. With the synergistic dispersion, adsorption, and heat conduction effects of vermiculite, activated carbon, and sodium chloride, the heat is quickly transferred to the affected area, catalyzing and stimulating the drug efficacy, and at the same time fully hot compressing the affected area, which can quickly generate the drug efficacy and quickly relieve the discomfort of the affected area through hot compress.

[0100] The method for using the navel patch provided in this embodiment is simple and convenient, suitable for pediatric use. The specific usage steps are as follows:

[0101] 1. Clean the abdominal skin of the child to ensure there is no oil and moisture.

[0102] 2. Take out the navel patch and tear off the protective film.

[0103] 3. Apply the navel patch to the navel part of the child and gently press to ensure it fits.

[0104] 4. According to needs, keep the navel patch on the abdomen for 4 - 8 hours, and the specific usage time can be adjusted according to the doctor's advice.

[0105] Through the above implementation solutions, this embodiment provides an effective antidiarrheal pharmaceutical composition for children with cold-damp diarrhea, as well as a safe, effective and easy-to-use umbilical patch product, which can effectively relieve the symptoms of children's diarrhea, reduce the side effects of drugs on the digestive tract, liver and kidneys, and ensure the safety and effectiveness of treatment. At the same time, the design of automatic heating improves the permeability of the drug and enhances the stability of the curative effect, generally meeting the market demand for products for treating children with cold-damp diarrhea and having good market prospects.

[0106] The various embodiments in this specification are described in a progressive manner. For the same or similar parts between the various embodiments, reference can be made to each other. Each embodiment focuses on the differences from other embodiments. The above embodiments are only used to illustrate the technical solutions of the present application and do not limit the present application. Although the present application has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the present application.

Claims

1. A medicinal composition for treating diarrhea caused by cold and dampness in children, characterized in that: The composition includes the following components in parts by weight: 5-12 parts of white pepper, 3-8 parts of cinnamon, 3-8 parts of Evodia rutaecarpa, 7-14 parts of gallnut, 5-12 parts of Atractylodes macrocephala, 5-12 parts of Poria cocos, 3-8 parts of dried ginger, and 2-4 parts of licorice.

2. A pharmaceutical composition for treating diarrhea caused by cold and dampness in children according to claim 1, characterized in that: At least part of the components are processed, and the specific operations of the processing include: Fry the white peppercorns over low heat until they are slightly yellow and slightly fragrant, then remove and let cool; Scrape the skin of cinnamon; Fry the Evodia rutaecarpa in salt water until fragrant; Fry the Atractylodes macrocephala with bran until it turns slightly yellow; Place the dried ginger on the fire and heat until smoke appears; Licorice is roasted with honey. Fry the licorice and honey together until it turns slightly yellow.

3. A umbilical patch for treating diarrhea caused by cold and dampness in children, comprising an adhesive patch and a functional dressing component, characterized in that: The functional dressing assembly comprises the following components: An appropriate amount of the pharmaceutical composition according to any one of claims 1 to 2; Auxiliary materials, the auxiliary materials include 9-21 parts of iron powder, 3-7 parts of sodium chloride, and 3-7 parts of vermiculite; The adhesive tape is a multi-layer film structure, which includes an adhesive tape layer, an intermediate layer and a breathable layer from bottom to top; A cavity is formed between the intermediate layer and the adhesive layer, and between the intermediate layer and the breathable layer; the pharmaceutical composition is filled in the cavity between the adhesive layer and the intermediate layer, and the auxiliary material is filled in the cavity between the breathable layer and the intermediate layer; The air permeable layer is provided with a plurality of air permeable micropores.

4. The antidiarrheal navel patch for children with cold-dampness type diarrhea according to claim 3, characterized in that: The auxiliary material also includes 6 to 14 parts of activated carbon.

5. A method for preparing a umbilical patch for treating cold-dampness type diarrhea in children, characterized in that: The following steps are involved: S1. Weigh 5-12 parts of white pepper, 3-8 parts of cinnamon bark, 3-8 parts of evodia rutaecarpa, 7-14 parts of gallnut, 5-12 parts of atractylodes macrocephala, 5-12 parts of poria, 3-8 parts of dried ginger, and 2-4 parts of licorice; S2. Pre-treating the raw materials weighed in S1, including the following operations: Fry the white peppercorns over low heat until they are slightly yellow and slightly fragrant, then remove and let cool; Scrape off the skin of cinnamon; Fry the Evodia rutaecarpa in salt water until fragrant; Fry the white atractylodes with bran until it turns slightly yellow; heat the dried ginger on the fire until smoke appears; Licorice is roasted with honey, frying the licorice with honey until it turns slightly yellow; S3, grinding each of the pretreated raw materials into fine powder; then adding an appropriate amount of rice vinegar or ginger juice to make a medicinal paste, wherein the amount of rice vinegar or ginger juice is such that the medicinal paste can form a mass and does not drip; S4, weigh 9-21 parts of iron powder, 6-14 parts of activated carbon, 3-7 parts of sodium chloride, and 3-7 parts of vermiculite as auxiliary materials; S5, mixing the auxiliary material raw materials weighed in S4 uniformly to obtain an auxiliary material composition; S6, coating the silicon-coated surface of the PET release film with an aqueous polyurethane emulsion, drying to form a film, and then coating the surface with an aqueous medical pressure-sensitive adhesive emulsion, and drying to obtain an adhesive layer; S7, placing the drug paste obtained in S3 on the side of the adhesive layer obtained in S6 coated with the aqueous medical pressure-sensitive adhesive latex, then taking a non-woven fabric as an intermediate layer, and bonding and fixing the edge of the intermediate layer to the edge of the adhesive layer on the side; S8. Place the auxiliary material composition obtained in S5 on the side of the middle layer that is not bonded to the adhesive layer, then use a microporous breathable membrane as a breathable layer, and bond the edge of the breathable layer to the edge of the side of the middle layer to obtain the umbilical patch for treating diarrhea caused by cold and dampness in children; place the umbilical patch for treating diarrhea caused by cold and dampness in children into an airtight outer bag and seal it for storage.

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