Crystallization apparatus for oxytetracycline hydrochloride and method of operation thereof

Abstract

The application belongs to the technical field of separation, and particularly relates to a terramycin hydrochloride crystallization device and a working method thereof. The terramycin hydrochloride crystallization device comprises: a feeding mechanism arranged on a crystallization mechanism, the feeding mechanism being in communication with the crystallization mechanism, and raw materials being crystallized in the crystallization mechanism after entering the crystallization mechanism through the feeding mechanism; a plurality of feeding flow channels are arranged in the feeding mechanism, and a filter bag is arranged in each feeding flow channel; a cleaning mechanism is arranged outside the feeding mechanism, the cleaning mechanism comprises a cleaning assembly corresponding to the filter bag, an air outlet of the cleaning assembly is located above an inner bottom surface of the corresponding filter bag, the cleaning assembly is suitable for blowing impurities on the inner bottom surface of the filter bag, and the cleaning assembly avoids that the air outlet of the cleaning assembly is blocked, so that the situation that the inner diameter of the inner pipeline is reduced or blocked, and the air output and the air output range are affected is avoided.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of general chemical devices, in particular to the field of separation technology, and more particularly to a terramycin hydrochloride crystallization device and a working method thereof. BACKGROUND

[0002] In the preparation process of terramycin hydrochloride, crystallization needs to be precipitated first and then dried. However, when the raw material is input into the crystallization mechanism, the impurities in the raw material will block the filter mechanism, resulting in unsmooth flow of the raw material, increasing the crystallization precipitation time and reducing the crystallization precipitation efficiency.

[0003] Therefore, in order to solve the technical problem of the reduction of the crystallization precipitation efficiency caused by the blocking of the filter mechanism during the input of the raw material, a terramycin hydrochloride crystallization device and a working method thereof are needed to be designed.

[0004] It should be noted that the above information disclosed in the background section of the present application is only used to understand the background of the present application, and therefore, the above description is not considered to constitute prior art information. SUMMARY

[0005] The present application at least provides a terramycin hydrochloride crystallization device and a working method thereof.

[0006] In a first aspect, the present application provides a terramycin hydrochloride crystallization device, comprising:

[0007] a crystallization mechanism and a feeding mechanism;

[0008] The feeding mechanism is arranged on the crystallization mechanism, and the feeding mechanism is in communication with the crystallization mechanism. The raw material enters the crystallization mechanism through the feeding mechanism and is crystallized in the crystallization mechanism.

[0009] A plurality of feeding flow channels are arranged in the feeding mechanism, the feeding flow channels are in communication with the crystallization mechanism, and a filter bag is arranged in the feeding flow channel.

[0010] A cleaning mechanism is arranged outside the feeding mechanism and extends into the feeding mechanism. The cleaning mechanism includes a cleaning assembly corresponding to the filter bag. The gas outlet of the cleaning assembly is located above the inner bottom surface of the corresponding filter bag. The inner diameter of the inner pipeline of the cleaning assembly is increased to avoid the blocking of the gas outlet of the inner pipeline.

[0011] In an alternative embodiment, the cleaning mechanism includes a gas tank and a plurality of gas conveying pipes.

[0012] The gas tank is arranged outside the feeding mechanism, and the gas tank stores gas.

[0013] The gas conveying pipes are arranged on the gas tank, and part of the gas conveying pipes extends into the feeding mechanism.

[0014] The gas pipe is in communication with the gas tank;

[0015] The cleaning assembly is connected with and in communication with the gas pipe, and is located in the feeding mechanism.

[0016] In an alternative embodiment, the cleaning assembly comprises an inner pipe and an outer pipe which are sleeved with each other;

[0017] A chamber is formed between the inner pipe and the outer pipe, and the bottom surface of the chamber is sealed, and the sealing is close to the bottom end of the inner pipe;

[0018] The air pump is electrically connected with the control module, the control module controls the air pump to exhaust the gas in the chamber, so that the air pressure in the chamber is reduced, and then the inner diameter of the inner pipe is increased to avoid the air outlet of the inner pipe being blocked.

[0019] In an alternative embodiment, the bottom end of the inner pipe is an air outlet, and the air outlet is located above the inner bottom surface of the filter bag;

[0020] The inner pipe and the outer pipe are both connected with the gas pipe;

[0021] The top of the inner pipe is in communication with a first air passage in the gas pipe, and the first air passage is in communication with the gas tank;

[0022] The top of the chamber is in communication with a second air passage in the gas pipe, and the second air passage is connected with the air pump through an air exhaust pipe;

[0023] The inner pipe is made of a flexible material;

[0024] The gas in the gas tank is blown to the impurities on the inner bottom surface of the filter bag through the inner pipe.

[0025] In an alternative embodiment, a valve is arranged between the gas tank and the gas pipe, the valve is electrically connected with the control module, and the control module is configured to control the valve to be opened to introduce the gas into the gas pipe;

[0026] A gas supplementing opening is formed in the gas tank.

[0027] In an alternative embodiment, the feeding mechanism comprises a sleeve;

[0028] The sleeve is connected with the tank body in the crystallization mechanism;

[0029] A plurality of feeding flow channels are vertically arranged in the sleeve, and the bottom of the feeding flow channel is in communication with the tank body;

[0030] A feeding opening is formed in the side wall of the sleeve, and the feeding opening is above the top surface of the feeding flow channel;

[0031] The filter bag is arranged in the feeding channel, and the air outlet of the cleaning assembly is located in the corresponding filter bag and above the bottom surface of the filter bag.

[0032] The top surface of the sleeve is provided with a cover.

[0033] In an optional embodiment, the crystallization mechanism comprises a tank body.

[0034] The tank body is arranged transversely, and a stirring mechanism is arranged in the tank body and is adapted to stir raw materials entering the tank body.

[0035] A heating mechanism is arranged on the tank body, and hot gas is introduced into the tank body to dry the crystals precipitated in the tank body.

[0036] In an optional embodiment, the stirring mechanism comprises a stirring shaft and stirring blades.

[0037] The stirring shaft is transversely arranged in the tank body.

[0038] The stirring blades are arranged on the stirring shaft.

[0039] A driving motor is arranged outside the tank body, and the stirring shaft is connected to the driving motor.

[0040] The driving motor is electrically connected to a control module, and the control module is configured to control the driving motor to drive the stirring shaft to rotate.

[0041] In an optional embodiment, the heating mechanism comprises an air inlet connector and an air outlet connector.

[0042] The air inlet connector and the air outlet connector are arranged on the outer wall of the tank body.

[0043] Steam is introduced into the tank body through the air inlet connector, and the gas in the tank body is discharged through the air outlet connector.

[0044] When the steam enters the inner pipeline of the cleaning assembly, the gas in the chamber between the inner pipeline and the outer pipeline of the cleaning assembly is extracted by the air extraction pump, so that the steam condenses and adheres to the inner wall of the inner pipeline, the crystals on the inner wall of the inner pipeline are melted, and the outlet of the inner pipeline is prevented from being blocked.

[0045] In an optional embodiment, the bottom of the tank body is provided with a liquid outlet.

[0046] The tank body is provided with a discharge port, and the discharge port is provided with a baffle.

[0047] In a second aspect, the embodiments of the present disclosure further provide a working method of the crystallization device for terramycin hydrochloride, comprising:

[0048] The raw material is introduced into the crystallization mechanism through the feeding mechanism, crystallized in the crystallization mechanism, and dried;

[0049] The cleaning assembly blows the impurities on the bottom surface of the filter bag, and the cleaning assembly avoids blocking the air outlet of the cleaning assembly.

[0050] The crystallization device of terramycin hydrochloride provided by the present application comprises a crystallization mechanism and a feeding mechanism, the feeding mechanism is arranged on the crystallization mechanism, the feeding mechanism is in communication with the crystallization mechanism, raw materials are crystallized in the crystallization mechanism after being introduced into the crystallization mechanism through the feeding mechanism, a plurality of feeding flow channels are arranged in the feeding mechanism, the feeding flow channels are in communication with the crystallization mechanism, filter bags are arranged in the feeding flow channels, a cleaning mechanism is arranged outside the feeding mechanism and extends into the feeding mechanism, the cleaning mechanism comprises cleaning assemblies corresponding to the filter bags, air outlets of the cleaning assemblies are located above the bottom surfaces of the corresponding filter bags, and the inner diameter of the inner pipeline of the cleaning assembly is increased to avoid blocking of the air outlet of the inner pipeline, so that the situation that the air outlet and the air range are affected due to the reduction or blockage of the inner diameter of the inner pipeline is avoided.

[0051] Other features and advantages of the present application will be set forth in the following description, and in part will become apparent to those skilled in the art from the description, or can be learned by practice of the present application. The objects and other advantages of the present application will be realized and achieved by the structure particularly pointed out in the description and the drawings.

[0052] In order to make the above-mentioned objects, features and advantages of the present application more obvious and easy to understand, the preferred embodiments are described in detail below, and the accompanying drawings are described as follows. BRIEF DESCRIPTION OF DRAWINGS

[0053] In order to more clearly illustrate the specific embodiments of the present application or the technical solutions in the prior art, the following will briefly introduce the drawings needed to be used in the specific embodiments or the prior art description. Obviously, the drawings in the following description are some embodiments of the present application, and those skilled in the art can also obtain other drawings according to these drawings without creative labor.

[0054] Figure 1 A structural schematic diagram of a crystallization device of terramycin hydrochloride provided by the present application is shown in the figure.

[0055] Figure 2 An internal structural schematic diagram of a feeding mechanism provided by the present application is shown in the figure.

[0056] Figure 3 A sectional view of a cleaning assembly provided by the present application is shown in the figure.

[0057] Figure 4A structural schematic diagram of a crystallization mechanism provided by an embodiment of the present disclosure;

[0058] Figure 5 A sectional view of a crystallization mechanism provided by an embodiment of the present disclosure;

[0059] Figure 6 A principle block diagram of a crystallization device of terramycin hydrochloride provided by an embodiment of the present disclosure.

[0060] In the figure:

[0061] 1 crystallization mechanism, 11 tank body, 12 stirring mechanism, 121 stirring shaft, 122 stirring blade, 123 driving motor, 13 heating mechanism, 131 air inlet joint, 132 air outlet joint, 14 liquid outlet, 15 baffle;

[0062] 2 feeding mechanism, 21 sleeve, 22 feeding flow channel, 23 feeding port, 24 filter bag, 25 cover body;

[0063] 3 cleaning mechanism, 31 gas tank, 32 gas conveying pipe, 321 first gas channel, 322 second gas channel, 33 cleaning assembly, 331 inner pipe, 332 outer pipe, 333 chamber, 334 air extraction pump, 335 air extraction pipe, 34 valve, 35 air supplement port. DETAILED DESCRIPTION

[0064] In order to make the purpose, technical solutions and advantages of the embodiments of the present disclosure clearer, the technical solutions of the present disclosure will be described clearly and completely below with reference to the drawings. Obviously, the described embodiments are some of the embodiments of the present disclosure, but not all the embodiments. Based on the embodiments in the present disclosure, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present disclosure.

[0065] In this document, when it is mentioned that a first component is located on a second component, it can mean that the first component can be directly formed on the second component, or a third component can be interposed between the first component and the second component. In addition, in the drawings, in order to effectively describe the technical content, the thickness of the components can be exaggerated or reduced.

[0066] As used herein, the phrases “in one embodiment,” “according to one embodiment,” “in some embodiments,” and the like generally mean the particular feature, structure, or characteristic following the phrase can be included in at least one embodiment of the present disclosure. Thus, the particular feature, structure, or characteristic can be included in more than one embodiment of the present disclosure, so that the phrases, “in one embodiment,” “according to one embodiment,” “in some embodiments,” and the like, are not necessarily referring to the same embodiment. As used herein, the terms “example,” “exemplary,” and the like are used as examples, instances, or illustrations. Any implementation, aspect or design described herein as “example” or “exemplary” is not necessarily to be construed as preferred or advantageous over other implementations, aspects or designs. Rather, the use of the terms “example,” “exemplary,” and the like is intended to present concepts in a concrete manner.

[0067] The existing oxytetracycline hydrochloride preparation process is that the liquid raw material is filtered through a filter bag and then introduced into the tank body of a crystallization mechanism, a gas with an appropriate temperature is introduced into the tank body to make the solution reach the crystallization temperature and stirring is performed for crystallization, the liquid in the crystal is filtered out, and then hot air is introduced into the tank body to dry the crystal. In the process of oxytetracycline hydrochloride crystallization, the liquid raw material needs to be first introduced into the crystallization mechanism, and the raw material enters the crystallization mechanism after being filtered through the filter bag. However, the inventors found that the filter bag would be blocked by impurities in the raw material, which would cause the raw material to be unable to enter the crystallization mechanism or to enter the crystallization mechanism at a very slow speed, thereby greatly increasing the time for all the raw material to complete the crystallization and precipitation, affecting the efficiency of crystallization. The filter bag can be opened by blowing the impurities, so that the raw material can smoothly enter the crystallization mechanism. However, the inventors also found that the raw material would enter the inner wall of the inner pipeline of the cleaning mechanism for blowing the impurities due to splashing and the like, and the raw material would precipitate on the inner wall of the inner pipeline to cause the inner pipeline to be blocked, thereby affecting the efficiency of the raw material entering the crystallization mechanism.

[0068] The above-mentioned defects are the results of the inventors' practice and careful research, and therefore, the discovery process of the above-mentioned problems and the solutions proposed by the present disclosure for the above-mentioned problems should be the contributions of the inventors to the present disclosure.

[0069] It should be noted that similar reference numerals and letters refer to like items in the accompanying drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0070] Some embodiments of the present disclosure will be described in detail below with reference to the accompanying drawings. The following embodiments and features in the embodiments can be combined with each other without conflict.

[0071] As Figure 1As shown, at least one disclosed embodiment provides a crystallization apparatus for oxytetracycline hydrochloride, comprising: a crystallization mechanism 1 and a feeding mechanism 2; the feeding mechanism 2 is disposed on the crystallization mechanism 1 and is connected to the crystallization mechanism 1, and the raw material enters the crystallization mechanism 1 through the feeding mechanism 2 and crystallizes in the crystallization mechanism 1; the feeding mechanism 2 is provided with a plurality of feeding channels 22, the feeding channels 22 are connected to the crystallization mechanism 1, and filter bags 24 are disposed in the feeding channels 22; a cleaning mechanism 3 is disposed outside the feeding mechanism 2 and extends into the feeding mechanism 2, the cleaning mechanism 3 includes a cleaning component 33 corresponding to the filter bag 24, the air outlet of the cleaning component 33 is located above the inner bottom surface of the corresponding filter bag 24, and the inner diameter of the inner pipe 331 in the cleaning component 33 is increased to avoid the air outlet of the inner pipe 331 being blocked, thereby avoiding the situation where the air volume and air range are affected by the reduction or blockage of the inner diameter of the inner pipe 331.

[0072] In this embodiment, the cleaning component 33 is adapted to blow away impurities on the inner bottom surface of the filter bag 24, thereby blowing away impurities on the inner bottom surface of the filter bag 24 during the filtering process, preventing the inner bottom surface of the filter bag 24 from being blocked by impurities, ensuring that the raw material can pass through the filter bag 24, preventing the filter bag 24 from being blocked and preventing the raw material from entering the crystallization mechanism 1, ensuring the speed at which the raw material enters the crystallization mechanism 1, preventing the time for the raw material to enter the crystallization mechanism from increasing and thus increasing the time for crystal precipitation, and ensuring the efficiency of crystallization.

[0073] In this embodiment, the raw material is in a liquid state. The raw material may adhere to the inner wall of the inner pipe 331 due to splashing or other reasons. The raw material adhering to the inner pipe 331 may crystallize, causing the inner diameter of the inner pipe 331 to decrease or even become blocked. The decrease or blockage of the inner diameter of the inner pipe 331 will affect the air output and air output range, which will result in the inability to blow away impurities on the inner bottom surface of the filter bag 24.

[0074] like Figure 2 As shown, in one optional embodiment, the cleaning mechanism 3 includes: a gas tank 31 and a plurality of gas supply pipes 32; the gas tank 31 is disposed outside the feeding mechanism 2, and the gas tank 31 stores gas; the gas supply pipes 32 are disposed on the gas tank 31, and a portion of the gas supply pipes 32 extends into the feeding mechanism 2; the gas supply pipes 32 are connected to the gas tank 31; the cleaning assembly 33 is connected to and communicates with the gas supply pipes 32, and the cleaning assembly 33 is located inside the feeding mechanism 2.

[0075] In this embodiment, the gas tank 31 can store high-pressure gas so that the gas can be sprayed out from the cleaning assembly 33 after passing through the gas delivery pipe 32.

[0076] like Figure 3 and Figure 6As shown, in an alternative embodiment, the cleaning assembly 33 comprises: an inner pipe 331 and an outer pipe 332; the outer pipe 332 is sleeved on the outer side of the inner pipe 331, the bottom end of the inner pipe 331 is flush with the bottom end of the outer pipe 332; the bottom end of the inner pipe 331 is an air outlet, which is located above the inner bottom surface of the filter bag 24; the inner pipe 331 and the outer pipe 332 are connected with the gas conveying pipe 32; the top of the inner pipe 331 is in communication with the first air channel 321 in the gas conveying pipe 32, and the first air channel 321 is in communication with the gas tank 31; a cavity 333 is formed between the inner pipe 331 and the outer pipe 332, the bottom surface of the cavity 333 is sealed, and the sealing is close to the bottom end of the inner pipe 331; the top of the cavity 333 is in communication with the second air channel 322 in the gas conveying pipe 32, and the second air channel 322 is connected with the air pump 334 through the air suction pipe 335; the inner pipe 331 is made of flexible material; the gas in the gas tank 31 is blown to the impurities on the inner bottom surface of the filter bag 24 through the inner pipe 331; the air pump 334 is electrically connected with the control module, and the control module controls the air pump 334 to exhaust the gas in the cavity 333, so that the air pressure in the cavity 333 decreases, and then the inner diameter of the inner pipe 331 increases to avoid the air outlet of the inner pipe 331 being blocked.

[0077] In this embodiment, the gas in the inner pipe 331 is blown out through the first air channel 321, and the gas comes from the gas tank 31.

[0078] In this embodiment, the bottom end of the inner pipe 331 is flush with the bottom end of the outer pipe 332, which can better clean the crystals remaining on the inner wall of the inner pipe 331.

[0079] In this embodiment, the direction of the gas flow in the inner pipe 331 when the gas is blown is shown as F in the figure, and the direction of the gas flow in the cavity 333 when the gas is exhausted is shown as f in the figure.

[0080] In this embodiment, the gas in the cavity 333 can be exhausted through the second air channel 322, and the gas can be supplemented into the cavity 333, and the first air channel 321 and the second air channel 322 are arranged separately, so that the first air channel 321 and the second air channel 322 do not affect each other.

[0081] In this embodiment, the inner pipe 331 is made of flexible material, so that the inner pipe 331 can be deformed to increase the inner diameter of the inner pipe 331; if crystals are precipitated from the raw materials remaining on the inner wall of the inner pipe 331, the air pressure in the cavity 333 is decreased by exhausting the gas in the cavity 333, so that the outer wall of the inner pipe 331 approaches the inner wall of the outer pipe 332, the inner pipe 331 is deformed to increase the inner diameter, and the exhaust amount and the exhaust range of the inner pipe 331 are ensured not to be affected by the precipitated crystals.

[0082] In this embodiment, when the raw material enters the filter bag 24, air can be blown out through the inner pipe 331. The airflow pushes the raw material through the filter bag 24, which can accelerate the entry of the raw material into the crystallization mechanism 1 and improve the crystallization efficiency. If the impurities accumulated on the inner bottom surface of the filter bag 24 cause the inner bottom surface of the filter bag 24 to be blocked, the air blown out by the inner pipe 331 can blow away the impurities on the inner bottom surface of the filter bag 24. The impurities will accumulate towards the edge of the inner bottom surface of the filter bag 24, and the central area of ​​the inner bottom surface of the filter bag 24 will be exposed without impurities. This ensures that there is still an area without impurities on the inner bottom surface of the filter bag 24, preventing the filter bag 24 from being blocked and preventing the raw material from entering the crystallization mechanism 1.

[0083] In this embodiment, by extracting the gas from the chamber 333, the area from which the gas is blown out of the inner pipe 331 is ensured, so that a corresponding size of impurity-free area can be blown out on the bottom surface of the filter bag 24, ensuring that the filter bag 24 will not be completely blocked by impurities, and ensuring that the raw material can pass through the filter bag 24 and enter the tank 11.

[0084] In one optional embodiment, a valve 34 is provided between the gas tank 31 and the gas supply pipe 32. The valve 34 is electrically connected to a control module, which is configured to control the valve 34 to open so as to introduce gas into the gas supply pipe 32. A gas replenishment port 35 is provided on the gas tank 31.

[0085] In this embodiment, valve 34 can be a solenoid valve or the like, and is controlled by a control module. When the inner pipe 331 needs to blow air outward, the control module controls valve 34 to open, so that the gas in the gas tank 31 can be blown out through the inner pipe 331.

[0086] In this embodiment, gas can be added to the gas tank 31 through the gas inlet 35 to ensure that gas can be blown out of the inner pipe 331.

[0087] like Figure 2 As shown, in one optional embodiment, the feeding mechanism 2 includes: a sleeve 21; the sleeve 21 is connected to the tank 11 in the crystallization mechanism 1; a plurality of feeding channels 22 are vertically arranged in the sleeve 21, and the bottom of the feeding channels 22 communicates with the tank 11; a feeding port 23 is opened on the side wall of the sleeve 21, and the feeding port 23 is located above the top surface of the feeding channel 22; a filter bag 24 is arranged in the feeding channel 22, and the air outlet of the cleaning component 33 is located inside the corresponding filter bag 24 and above the bottom surface of the filter bag 24; a cover 25 is provided on the top surface of the sleeve 21.

[0088] In this embodiment, the cover 25 may be provided with air holes to facilitate the discharge of gas from the sleeve 21.

[0089] In this embodiment, the cover 25 can prevent the raw materials entering the sleeve 21 from splashing out of the sleeve 21.

[0090] In this embodiment, the speed at which raw materials enter the crystallization mechanism 1 can be increased by setting multiple feed channels 22.

[0091] like Figure 4 As shown, in an optional embodiment, the crystallization mechanism 1 includes: a tank 11; the tank 11 is arranged horizontally, and a stirring mechanism 12 is provided inside the tank 11, the stirring mechanism 12 being adapted to stir the raw materials entering the tank 11; a heating mechanism 13 is provided on the tank 11, the heating mechanism 13 introducing hot air into the tank 11 to dry the crystals precipitated inside the tank 11.

[0092] In this embodiment, the stirring mechanism 12 can stir the raw materials entering the tank 11, thereby increasing the rate of crystallization.

[0093] In this embodiment, during the crystallization process, the control module repeatedly controls the operation of the vacuum pump 334. When the vacuum pump 334 is working, it extracts the gas from the chamber 333, causing the inner diameter of the inner pipe 331 to increase. When the vacuum pump 334 is not working, the external gas re-enters the chamber 333, causing the gas pressure in the chamber 333 to recover and the inner diameter of the inner pipe 331 to decrease. This process is repeated, causing the inner pipe 331 to deform repeatedly, shaking off the crystals precipitated on the inner wall of the inner pipe 331.

[0094] In this embodiment, after crystallization is completed, hot air is introduced into the tank 11 to dry the crystals.

[0095] like Figure 5 As shown, in one optional embodiment, the stirring mechanism 12 includes: a stirring shaft 121 and stirring blades 122; the stirring shaft 121 is transversely inserted into the tank body 11; the stirring blades 122 are disposed on the stirring shaft 121; a drive motor 123 is disposed outside the tank body 11, and the stirring shaft 121 is connected to the drive motor 123; the drive motor 123 is electrically connected to a control module, and the control module is configured to control the drive motor 123 to drive the stirring shaft 121 to rotate.

[0096] like Figure 4As shown, in an alternative embodiment, the heating mechanism 13 comprises: an air inlet joint 131 and an air outlet joint 132; the air inlet joint 131 and the air outlet joint 132 are arranged on the outer wall of the tank body 11; steam is introduced into the tank body 11 through the air inlet joint 131, and the gas in the tank body 11 is discharged through the air outlet joint 132; when the steam enters the inner pipeline 331 of the cleaning assembly 33, the gas in the chamber 333 between the inner pipeline 331 and the outer pipeline 332 of the cleaning assembly 33 is pumped out by the air pump 334, so that the steam condenses and adheres to the inner wall of the inner pipeline 331, and the crystals on the inner wall of the inner pipeline 331 are melted, avoiding the blockage of the gas outlet of the inner pipeline 331.

[0097] In this embodiment, the air inlet joint 131 can be connected to a steam generator, and the steam generated by the steam generator can enter the tank body 11.

[0098] In this embodiment, the air outlet joint 132 can be connected to an external pipeline to facilitate the discharge of gas in the tank body 11.

[0099] In this embodiment, the steam can be water vapor or the like.

[0100] In this embodiment, during the crystallization process, the gas at an appropriate temperature can be introduced into the tank body 11 through the air inlet joint 131, so that the temperature in the tank body 11 is maintained at the temperature required for crystallization.

[0101] In this embodiment, after the crystallization is completed, steam can be introduced into the tank body 11 to dry the crystals in the tank body 11.

[0102] In this embodiment, the air outlet joint 132 can ensure that the gas can be discharged from the air outlet joint 132 when the gas is introduced into the tank body 11, avoiding excessive pressure in the tank body 11.

[0103] In the present embodiment, part of the steam in the drying process will enter the sleeve 21 and then pass through the filter bag 24 into the inner pipe 331, at this time the gas in the chamber 333 will be repeatedly pumped out, after the gas in the chamber 333 is pumped out, the pressure in the chamber 333 decreases, and the temperature in the chamber 333 will decrease due to the decrease in air pressure, at this time the steam will condense and adhere to the inner wall of the inner pipe 331 after contacting the inner wall of the inner pipe 331, the crystals that were precipitated and adhered to the inner wall of the inner pipe 331 will be redissolved and then drip to remove the crystals on the inner wall of the inner pipe 331; After the gas in the chamber 333 is pumped out by the air pump 334, the air pump 334 stops pumping, at this time the gas outside the chamber 333 with lower temperature than the steam will enter the chamber 333, reducing the temperature of the inner pipe 331, increasing the temperature difference between the inner pipe 331 and the steam, so that the steam contacting the inner pipe 331 can condense smoothly, and the air pump 334 repeatedly stops working, so that the external air can repeatedly enter the chamber 333, ensuring the condensation effect of the steam, and further ensuring the effect of removing the precipitated crystals.

[0104] In an alternative embodiment, the bottom of the tank body 11 is provided with a liquid outlet 14; the tank body 11 is provided with a discharge port, and the discharge port is provided with a baffle 15.

[0105] In the present embodiment, a filter screen can be provided in the liquid outlet 14, and after the crystallization is completed, the residual solution in the tank body 11 is discharged by opening the liquid outlet 14, and the precipitated crystals are retained in the tank body 11.

[0106] In the present embodiment, after the drying is completed, the baffle 15 can be opened and then the dried crystals are taken out of the tank body 11.

[0107] At least one other disclosed embodiment also provides a working method of the above-mentioned terramycin hydrochloride crystallization device, comprising: the raw material enters the crystallization mechanism 1 through the feeding mechanism 2, and the crystals are precipitated and dried in the crystallization mechanism 1; the cleaning assembly 33 blows the impurities on the inner bottom surface of the filter bag 24, and the cleaning assembly 33 avoids blocking the air outlet thereof.

[0108] In summary, the crystallization device of terramycin hydrochloride, comprising: a crystallization mechanism 1 and a feeding mechanism 2; the feeding mechanism 2 is arranged on the crystallization mechanism 1, the feeding mechanism 2 is communicated with the crystallization mechanism 1, and the raw material is crystallized in the crystallization mechanism 1 after entering the crystallization mechanism 1 through the feeding mechanism 2; a plurality of feeding flow channels 22 are arranged in the feeding mechanism 2, the feeding flow channels 22 are communicated with the crystallization mechanism 1, and a filter bag 24 is arranged in the feeding flow channel 22; a cleaning mechanism 3 is arranged outside the feeding mechanism 2 and extends into the feeding mechanism 2, the cleaning mechanism 3 comprises a cleaning assembly 33 corresponding to the filter bag 24, the air outlet of the cleaning assembly 33 is located above the inner bottom surface of the corresponding filter bag 24, the cleaning assembly 33 is suitable for blowing the impurities on the inner bottom surface of the filter bag 24, and the cleaning assembly 33 avoids that the air outlet is blocked, the inner diameter of the inner pipeline 331 is reduced or blocked, the air volume and the air range are affected, the impurities on the inner bottom surface of the filter bag 24 are blown away in the process of filtering the raw material, the inner bottom surface of the filter bag 24 is prevented from being blocked by the impurities, the raw material can pass through the filter bag 24, the raw material cannot enter the crystallization mechanism 1 due to the blockage of the filter bag 24, the speed of the raw material entering the crystallization mechanism 1 is ensured, the crystallization time is prevented from being increased, and the crystallization efficiency is ensured.

[0109] In the description of the embodiments of the present application, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connecting" should be understood in a broad sense, for example, can be fixed connection, can also be detachable connection, or integrally connected; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0110] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, therefore cannot be understood as a limitation on the present application. In addition, terms such as "first", "second" and other numerical terms are used herein without implying a sequence or order, unless the context clearly indicates otherwise. Therefore, the first element, component, region, layer or section discussed above can be referred to as the second element, component, region, layer or section without departing from the teachings of the example embodiments.

[0111] Spatially relative terms, such as "inner," "outer," "beneath," "below," "lower," "above," "upper," and the like, can be used herein for ease of description to describe one element or feature's relationship to another element(s) or feature(s) as illustrated in the figures. Spatially relative terms can be intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" the other elements or features. Thus, the example term "below" can encompass both an orientation of above and below. The device can be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

[0112] With the above ideal embodiments according to the present application as the inspiration, through the above description, relevant workers can certainly make various changes and modifications within the scope of not deviating from the technical idea of the present application. The technical scope of the present application is not limited to the content in the specification, and must be determined according to the scope of claims.

Claims

1. A crystallization apparatus for terramycin hydrochloride, characterized by, The crystallization device comprises a crystallization mechanism (1) and a feeding mechanism (2). The feeding mechanism (2) is arranged on the crystallization mechanism (1) and communicates with the crystallization mechanism (1), and raw materials enter the crystallization mechanism (1) through the feeding mechanism (2) and are crystallized in the crystallization mechanism (1). The feeding mechanism (2) is provided with a plurality of feeding flow channels (22) which communicate with the crystallization mechanism (1) and are provided with filter bags (24) inside. The feeding mechanism (2) is provided with a cleaning mechanism (3) which extends into the feeding mechanism (2), and the cleaning mechanism (3) comprises cleaning assemblies (33) corresponding to the filter bags (24), the gas outlet of the inner pipeline (331) of the cleaning assembly (33) is located above the inner bottom surface of the corresponding filter bag (24), and the inner pipeline (331) is increased in inner diameter to avoid blockage of the gas outlet of the inner pipeline (331). The cleaning assembly (33) comprises an inner pipeline (331) and an outer pipeline (332) which are sleeved with each other. A chamber (333) is formed between the inner pipeline (331) and the outer pipeline (332), the bottom surface of the chamber (333) is in a sealed state, and the sealing is close to the bottom end of the inner pipeline (331). The air pump (334) is electrically connected with a control module, the control module controls the air pump (334) to exhaust the gas in the chamber (333), so that the air pressure in the chamber (333) decreases, and the inner diameter of the inner pipeline (331) is increased to avoid blockage of the gas outlet of the inner pipeline (331).

2. The crystallization device of terramycin hydrochloride according to claim 1, wherein the cleaning mechanism (3) comprises a gas tank (31) and a plurality of gas conveying pipes (32). The gas tank (31) is arranged outside the feeding mechanism (2), and the gas tank (31) stores gas. The gas conveying pipes (32) are arranged on the gas tank (31) and extend into the feeding mechanism (2). The gas conveying pipes (32) communicate with the gas tank (31). The cleaning assembly (33) is connected with and communicates with the gas conveying pipes (32), and the cleaning assembly (33) is located in the feeding mechanism (2).

3. The crystallization device of terramycin hydrochloride according to claim 2, wherein the bottom end of the inner pipeline (331) is a gas outlet which is located above the inner bottom surface of the corresponding filter bag (24). The inner pipeline (331) and the outer pipeline (332) are connected with the gas conveying pipes (32). The top of the inner pipeline (331) communicates with a first gas passage (321) in the gas conveying pipe (32), and the first gas passage (321) communicates with the gas tank (31). The top of the chamber (333) communicates with a second gas passage (322) in the gas conveying pipe (32), and the second gas passage (322) is connected with the air pump (334) through an air pump (335). The inner pipeline (331) is made of a flexible material. ​ ​ ​ The gas in the gas tank (31) is blown to the inner bottom surface of the filter bag (24) through the inner pipeline (331), and the impurities on the inner bottom surface of the filter bag (24) are blown away.

4. The crystallization device of terramycin hydrochloride according to claim 2, characterized in that: A valve (34) is arranged between the gas tank (31) and the gas conveying pipe (32), the valve (34) is electrically connected with the control module, and the control module is configured to control the valve (34) to open to introduce gas into the gas conveying pipe (32); A gas supplementing opening (35) is arranged on the gas tank (31).

5. The crystallization device of terramycin hydrochloride according to claim 1, characterized in that: The feeding mechanism (2) comprises a sleeve (21); The sleeve (21) is connected with the tank body (11) in the crystallization mechanism (1); A plurality of feeding flow channels (22) are vertically arranged in the sleeve (21), and the bottom of the feeding flow channel (22) is communicated with the tank body (11); A feeding opening (23) is arranged on the side wall of the sleeve (21) and is above the top surface of the feeding flow channel (22); A filter bag (24) is arranged in the feeding flow channel (22), and the gas outlet of the cleaning assembly (33) is located in the filter bag (24) and above the inner bottom surface of the filter bag (24); A cover body (25) is arranged on the top surface of the sleeve (21).

6. The crystallization device of terramycin hydrochloride according to claim 1, characterized in that: The crystallization mechanism (1) comprises a tank body (11); The tank body (11) is horizontally arranged, a stirring mechanism (12) is arranged in the tank body (11), and the stirring mechanism (12) is suitable for stirring the raw material entering the tank body (11); A heating mechanism (13) is arranged on the tank body (11), the heating mechanism (13) introduces hot gas into the tank body (11) to dry the crystallization precipitated in the tank body (11); An outlet (14) is arranged at the bottom of the tank body (11); A discharge opening is arranged on the tank body (11), and a baffle (15) is arranged on the discharge opening.

7. The crystallization device of terramycin hydrochloride according to claim 6, characterized in that: The stirring mechanism (12) comprises a stirring shaft (121) and a stirring blade (122); The stirring shaft (121) is horizontally arranged in the tank body (11); The stirring blade (122) is arranged on the stirring shaft (121); A driving motor (123) is arranged outside the tank body (11), and the stirring shaft (121) is connected with the driving motor (123); The driving motor (123) is electrically connected with the control module, and the control module is configured to control the driving motor (123) to drive the stirring shaft (121) to rotate.

8. The crystallization device of terramycin hydrochloride according to claim 6, characterized in that: The heating mechanism (13) comprises an air inlet joint (131) and an air outlet joint (132); The air inlet joint (131) and the air outlet joint (132) are arranged on the outer wall of the tank body (11). Steam is introduced into the tank (11) through the gas inlet joint (131), and the gas in the tank (11) is discharged through the gas outlet joint (132); When the steam enters the inner pipeline (331) of the cleaning assembly (33), the gas in the chamber (333) between the inner pipeline (331) and the outer pipeline (332) of the cleaning assembly (33) is pumped out by the air pump (334), so that the steam condenses and adheres to the inner wall of the inner pipeline (331), and the crystals on the inner wall of the inner pipeline (331) are melted, avoiding the blockage of the gas outlet of the inner pipeline (331).

9. A method of operating a crystallization apparatus employing terramycin hydrochloride according to any one of claims 1-8, characterized in that, The application relates to a crystallization device and a crystallization method. After raw materials enter the crystallization mechanism (1) through the feeding mechanism (2), crystals are separated out in the crystallization mechanism (1) and dried; The cleaning assembly (33) blows the impurities on the inner bottom surface of the filter bag (24), and the cleaning assembly (33) avoids the blockage of the gas outlet thereof.

Images