Sample analyzer and control method of sample analyzer

Abstract

The invention is applicable to the field, and discloses a sample analyzer and a control method thereof, the sample analyzer controls a first power mechanism through a control device to drive a pipetting needle to suck a sample or a reagent, and performs sample or reagent discharge operation to a reaction container at a sample adding position; in the discharging operation process, the first power mechanism conveys at least part of the cleaning liquid into a needle tube of the pipetting needle; after the pipetting needle finishes discharging the sample or the reagent, the needle moving mechanism is controlled to drive the pipetting needle to move to a cleaning position, the pipetting device is controlled to perform cleaning operation, and the cleaning operation comprises the steps of controlling the first power mechanism to drive the pipetting needle to suck air, controlling the first power mechanism to drive the pipetting needle to discharge air and cleaning liquid, and controlling the first power mechanism to drive the pipetting needle to discharge the cleaning liquid. A residual liquid film on the inner wall of a needle tube of the pipetting needle is damaged by sucking air, so that the substance exchange efficiency of foreign matters and cleaning liquid during subsequent discharge of the air and the cleaning liquid is improved, and the cleaning effect of the inner wall of the needle tube of the pipetting needle is improved.

Description

Technical Field

[0001] The present invention relates to the field of sample analysis, and particularly to a sample analyzer and a control method thereof. Background Art

[0002] A sample analyzer is an analytical instrument that measures a certain parameter of a sample by measuring a mixture made of at least a sample and a reagent. Before preparing the mixture, a pipetting needle is used to transfer the sample or the reagent into a reaction vessel to obtain the mixture. After the transfer is completed, part of the sample or the reagent will remain on the inner wall of the pipetting needle. In order not to affect the measurement result of the next sample, after the pipetting needle completes the transfer of a sample or a reagent, the inner wall of the pipetting needle needs to be cleaned. The existing cleaning method is to discharge the cleaning liquid from the needle tube of the pipetting needle for flushing. The foreign matter remaining on the inner wall of the pipetting needle exchanges substances with the cleaning liquid by diffusion, so as to complete the cleaning of the inner wall of the pipetting needle. This cleaning method has low efficiency of substance exchange between the foreign matter and the cleaning liquid and poor cleaning effect. Summary of the Invention

[0003] The first object of the present invention is to provide a sample analyzer, which aims to solve the technical problem of low efficiency of substance exchange between foreign matter and cleaning liquid during the cleaning of the inner wall of the pipetting needle.

[0004] To achieve the above object, the solution provided by the present invention is: A sample analyzer, characterized by comprising:

[0005] A pipetting device for sucking and injecting a sample and / or a reagent, the pipetting device comprising a pipetting needle, a needle moving mechanism for driving the movement of the pipetting needle, a first power mechanism, a first cleaning liquid supply mechanism for providing a cleaning liquid, and a pipeline, the pipeline connecting the first cleaning liquid supply mechanism, the first power mechanism and the pipetting needle, and the first power mechanism being used to provide power for the pipetting needle to perform liquid suction and liquid discharge operations;

[0006] A measuring device for measuring a reaction solution made of at least a mixture of a sample and a reagent;

[0007] A cleaning device provided with a cleaning position for collecting waste liquid generated by cleaning the pipetting needle;

[0008] A control device is at least communicatively connected to the pipetting device, and the control device is configured to: control the first power mechanism to drive the pipetting needle to aspirate a sample or a reagent, perform a discharging operation of the sample or the reagent to a reaction vessel located at a sample adding position, and during the discharging operation, the first power mechanism conveys at least part of a cleaning liquid into the needle tube of the pipetting needle; after the sample or the reagent is discharged by the pipetting needle, control the needle moving mechanism to drive the pipetting needle to move to a cleaning position, and control the pipetting device to perform a cleaning operation, where the cleaning operation includes: controlling the first power mechanism to drive the pipetting needle to aspirate air, and controlling the first power mechanism to drive the pipetting needle to discharge the air and the cleaning liquid.

[0009] As an implementation manner, the control device is further configured to: after the pipetting needle finishes discharging the sample or the reagent and before the pipetting needle aspirates air, control the first power mechanism to drive the pipetting needle to discharge the cleaning liquid.

[0010] As an implementation manner, the control device is further configured to: after the pipetting needle aspirates air and before the pipetting needle discharges the air and the cleaning liquid, control the first power mechanism to stop driving for a first preset time.

[0011] As an implementation manner, the control device is further configured to: after the pipetting needle finishes discharging the sample or the reagent and before the pipetting needle aspirates air, when controlling the first power mechanism to drive the pipetting needle to discharge the cleaning liquid, perform: discharging a first part of the cleaning liquid, controlling the first power mechanism to stop driving for a second preset time, and after finishing the second preset time of stopping driving, controlling the first power mechanism to drive the pipetting needle to discharge a second part of the cleaning liquid.

[0012] As an implementation manner, during the process of the pipetting needle discharging the air and the cleaning liquid, the volume of the cleaning liquid discharged by the pipetting needle is greater than the volume of the air discharged by the pipetting needle.

[0013] As an implementation manner, the sample analyzer includes a cleaning operation in a first cleaning mode and a cleaning operation in a second cleaning mode, and in the cleaning operation in the first cleaning mode and the cleaning operation in the second cleaning mode, the volume of the cleaning liquid discharged by the pipetting needle and / or the volume of the air aspirated are different. The control device is further configured to: after the pipetting needle discharges a first sample or a first reagent, control to perform the cleaning operation in the first cleaning mode on the pipetting needle; after the pipetting needle discharges a second sample or a second reagent, control to perform the cleaning operation in the second cleaning mode on the pipetting needle; where the types of the first sample and the second sample are different, or the types of the first reagent and the second reagent are different.

[0014] As an implementation manner, the cleaning operation further includes: after the pipetting needle finishes discharging air and cleaning liquid, controlling the first power mechanism to drive the pipetting needle to perform air suction, air discharge, and cleaning liquid discharge again.

[0015] As an implementation manner, the cleaning device further includes an outer wall cleaning mechanism, a second power mechanism, and a second cleaning liquid supply mechanism connected by pipelines. The outer wall cleaning mechanism is used to spray cleaning liquid to clean the outer wall of the pipetting needle. The second cleaning liquid supply mechanism is used to supply cleaning liquid. The second power mechanism provides the power to drive the cleaning liquid for the outer wall cleaning of the outer wall cleaning mechanism. The control device is further configured to, when controlling the pipetting device to perform a cleaning operation, control the second power mechanism to drive the outer wall cleaning mechanism to spray cleaning liquid to clean the outer wall of the pipetting needle.

[0016] The second object of the present invention is to provide a sample analyzer, which is characterized by including:

[0017] A pipetting device for aspirating and dispensing samples and / or reagents. The pipetting device includes a pipetting needle, a needle moving mechanism for driving the movement of the pipetting needle, and a first power mechanism for providing power for the pipetting needle to perform sample and / or reagent aspiration and dispensing operations;

[0018] A measuring device for measuring a reaction solution made of at least a mixture of a sample and a reagent;

[0019] A cleaning device provided with a cleaning liquid supply position for providing cleaning liquid;

[0020] A control device is at least communicatively connected to the pipetting device. The control device is configured to: control the first power mechanism to drive the pipetting needle to aspirate a sample or a reagent, perform a discharging operation of the sample or the reagent to a reaction container located at the sample adding position, control the needle moving mechanism to drive the pipetting needle to move to the cleaning device, and control the pipetting needle to perform a cleaning operation. The cleaning operation includes controlling the needle moving mechanism to drive the pipetting needle to move to the cleaning liquid supply position, controlling the first power mechanism to drive the pipetting needle to aspirate the cleaning liquid provided by the cleaning liquid supply position, controlling the first power mechanism to drive the pipetting needle to aspirate air, and controlling the first power mechanism to drive the pipetting needle to discharge the air and the cleaning liquid.

[0021] As an implementation manner, the control device is further configured to, after the pipetting needle finishes aspirating the cleaning liquid and before the pipetting needle aspirates air, control the first power mechanism to drive the pipetting needle to discharge a part of the cleaning liquid in the pipetting needle.

[0022] As an implementation manner, the control device is further configured to control the first power mechanism to stop driving for a first preset time after the pipetting needle aspirates air and before the pipetting needle discharges the air and the cleaning liquid.

[0023] The third object of the present invention is to provide a control method for a sample analyzer, which is characterized by including:

[0024] Controlling the first power mechanism of the sample analyzer to drive the pipetting needle of the sample analyzer to perform an operation of aspirating a sample or a reagent, controlling the first power mechanism of the sample analyzer to drive the pipetting needle of the sample analyzer to perform an operation of discharging the sample or the reagent to a reaction vessel located at the sample addition position, and during the process of performing the operation of aspirating a sample or a reagent or the discharging operation, the first power mechanism conveys at least part of the cleaning liquid into the needle tube of the pipetting needle;

[0025] After the pipetting needle completes the discharge of the sample or the reagent, controlling the needle moving mechanism to drive the pipetting needle to move to the cleaning position, and controlling the pipetting needle to perform a cleaning operation, where the cleaning operation includes: controlling the first power mechanism to drive the pipetting needle to aspirate air, and controlling the first power mechanism to drive the pipetting needle to discharge the air and the cleaning liquid.

[0026] The fourth object of the present invention is to provide a control method for a sample analyzer, which is characterized by including:

[0027] Controlling the first power mechanism of the sample analyzer to drive the pipetting needle of the sample analyzer to perform an operation of aspirating a sample or a reagent, and controlling the first power mechanism to drive the pipetting needle to perform an operation of discharging the sample or the reagent to a reaction vessel located at the sample addition position;

[0028] Controlling the needle moving mechanism to drive the pipetting needle to move to the cleaning liquid supply position, controlling the first power mechanism to drive the pipetting needle to aspirate the cleaning liquid provided at the cleaning liquid supply position, controlling the first power mechanism to drive the pipetting needle to aspirate air, and controlling the first power mechanism to drive the pipetting needle to discharge the air and the cleaning liquid at the cleaning position.

[0029] The sample analyzer provided by the present invention adds operations of aspirating air and discharging air to the cleaning method of the inner wall of the pipetting needle in the sample analyzer in the related art by discharging the cleaning liquid through the needle tube of the pipetting needle. By aspirating a section of air to break the liquid film remaining on the inner wall of the needle tube of the pipetting needle, and then when discharging the air and the cleaning liquid, it is more conducive to the mass exchange between the cleaning liquid and the foreign matter on the inner wall of the needle tube of the pipetting needle, achieving the purpose of strengthening the cleaning and improving the cleaning effect. Description of the Drawings

[0030] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on the structures shown in these drawings.

[0031] Figure 1 is a block diagrammatic structural schematic diagram of a sample analyzer provided by an embodiment of the present invention;

[0032] Figure 2 is a structural schematic diagram of a pipetting device of a sample analyzer provided by an embodiment of the present invention;

[0033] Figure 3 is a liquid path diagram of a pipetting device and a cleaning device of a sample analyzer provided by an embodiment of the present invention;

[0034] Figure 4 is a liquid path diagram of a pipetting device and a cleaning device of another sample analyzer provided by an embodiment of the present invention;

[0035] Figure 5 is a step flow chart of a control method for a sample analyzer provided by an embodiment of the present invention;

[0036] Figure 6 is a step flow chart of a control method for another sample analyzer provided by an embodiment of the present invention.

[0037] Explanation of the reference numerals in the drawings: Sample analyzer 100, Pipetting device 10, Pipetting needle 11, Needle moving mechanism 12, First power mechanism 13, Cleaning liquid supply mechanism 14, Pipeline 15, Sample supply device 20, Sample supply position 21, Reagent supply device 30, Reagent supply position 31, Reaction device 40, Cleaning device 50, Outer wall cleaning mechanism 51, Cleaning pool 52, Waste liquid tank 53, Second power mechanism 54, Cleaning liquid supply position 55, Measuring device 60. Detailed implementation manners

[0038] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

[0039] It should be noted that all the directional indications (such as up, down, left, right, front, back...) in the embodiments of the present invention are only used to explain the relative positional relationship and movement conditions between components in a specific posture. If this specific posture changes, the directional indication will also change accordingly.

[0040] It should also be noted that when an element is referred to as "fixed to" or "disposed on" another element, it can be directly on the other element or there may be an intermediate element at the same time. When an element is referred to as "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element through an intermediate element.

[0041] In addition, the descriptions involving "first", "second", etc. in the present invention are only for descriptive purposes and should not be construed as indicating or implying their relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement it. When the combination of technical solutions results in contradictions or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0042] Embodiment 1:

[0043] Please refer to Figure 1 , this application provides a sample analyzer 100 for analyzing a sample to be tested to obtain a corresponding analysis result. In some embodiments, the sample analyzer 100 includes but is not limited to at least one of the following: biochemical analyzer, immunoassay analyzer, coagulation analyzer, urine analyzer. In some embodiments, the sample includes but is not limited to body fluids such as blood and urine.

[0044] As Figure 1 shown, the sample analyzer 100 includes a pipetting device 10, a sample supply device 20, a reagent supply device 30, a reaction device 40, a cleaning device 50, a measuring device 60, and a control device (not shown).

[0045] The sample supply device 20 includes a sample supply position 21 for providing a sample. The reagent supply device 30 includes a reagent supply position 31 for providing a reagent.

[0046] In some embodiments, as Figure 1As shown, the number of pipetting devices 10 is two sets. One pipetting device is a sample pipetting device and the other pipetting device is a reagent pipetting device. The sample pipetting device can move between the sample supply position 21 and the sample injection position. The sample pipetting device can aspirate the sample at the sample supply position 21 and discharge the sample into the reaction vessel located at the sample injection position. The reagent pipetting device can move between the reagent supply position 31 and the reagent injection position. The reagent pipetting device can aspirate the reagent at the reagent supply position 31 and discharge the reagent into the reaction vessel located at the reagent injection position. Those skilled in the art are familiar that the sample injection position and the reagent injection position can be the same injection position or different injection positions. When the injection positions are different, the reaction cup transfer mechanism transfers the reaction cup between different injection positions.

[0047] Please refer to Figure 2 、 Figure 3 Figure, the pipetting device 10 includes a pipetting needle 11, a needle moving mechanism 12 for driving the movement of the pipetting needle, a first power mechanism 13, a first cleaning liquid supply mechanism 14 for providing cleaning liquid, and a pipeline 15. The pipeline 15 connects the first cleaning liquid supply mechanism 14, the first power mechanism 13, and the pipetting needle 11. The first power mechanism 13 is used to provide power for the pipetting needle 11 to perform liquid aspiration and discharge operations.

[0048] The needle moving mechanism 12 of the sample pipetting device can drive the pipetting needle 11 of the sample pipetting device to perform horizontal and / or vertical movements, so that the pipetting needle 11 of the sample pipetting device can perform horizontal movement between the sample supply position 21 and the sample injection position. After being in the above positions, the height of the pipetting needle 11 is vertically lowered, and then the sample discharge or aspiration operation is performed. After completing the sample discharge or aspiration operation, the pipetting needle 11 is vertically raised, and then the pipetting needle 11 is driven to perform horizontal movement between the above positions. Similarly, the pipetting needle 11 of the reagent pipetting device can move between the reagent supply position 31 and the reagent injection position.

[0049] In some embodiments, the number of pipetting devices 10 is one set, that is, the pipetting device 10 has the functions of aspirating and discharging samples and aspirating and discharging reagents. The pipetting device 10 includes a pipetting needle 11, a needle moving mechanism 12 for driving the movement of the pipetting needle, a first power mechanism 13, a first cleaning liquid supply mechanism 14 for providing cleaning liquid, and a pipeline 15. The pipeline 15 connects the first cleaning liquid supply mechanism 14, the first power mechanism 13, and the pipetting needle 11. The first power mechanism 13 is used to provide power for the pipetting needle 11 to perform liquid aspiration and discharge operations.

[0050] The pipetting device 10 is used for aspirating and dispensing samples and / or reagents. The pipetting device 10 can move between a sample supply position 21, a reagent supply position 31, a sample dispensing position, and a reagent dispensing position. After aspirating a sample at the sample supply position 21, the pipetting device 10 discharges the sample into a reaction vessel located at the sample dispensing position. After aspirating a reagent at the reagent supply position 31, the pipetting device 10 discharges the reagent into the reaction vessel located at the reagent dispensing position. The needle moving mechanism 12 can drive the pipetting needle 11 to move horizontally and / or vertically. Horizontally, it drives the pipetting needle 11 to move between the sample supply position 21, the reagent supply position 31, the sample dispensing position, and the reagent dispensing position. After reaching the above positions, it vertically lowers the height of the pipetting needle, and then performs a liquid discharging or aspirating operation. After completing the liquid discharging or aspirating operation, it vertically raises the pipetting needle, and then drives the pipetting needle to move horizontally between the above positions. The pipetting needle 11 in the pipetting device 10 aspirates and discharges both samples and reagents. After aspirating and discharging a sample, the pipetting needle 11 is cleaned and then used to aspirate and discharge a reagent. The order of aspirating and discharging samples and reagents is not limited.

[0051] In some embodiments, the cleaning device 50 is provided with a cleaning position for collecting the waste liquid generated from cleaning the pipetting needle.

[0052] In some embodiments, the reaction device 40 has a support portion, and the support portion has at least one placement position for placing a reaction vessel. The reaction vessel receives a blood sample to be tested supplied by the sample supply device 20 and a reagent supplied by the reagent supply device 30 to form a sample liquid to be tested by mixing. For example, the reaction device 40 can be a reaction disk. For example Figure 1 as shown, it is arranged in a disk-like structure and has one or more placement positions for placing reaction vessels. The reaction disk can rotate and drive the reaction vessels in its placement positions to rotate, for scheduling the reaction vessels within the reaction disk and incubating the sample liquid to be tested in the reaction vessels.

[0053] It can be understood that the reaction device 40 can also be a fixed reaction vessel placement position, and the reaction vessel is placed at this position for a predetermined time to complete incubation and / or other operations (such as mixing).

[0054] The measuring device 60 is used for optically measuring the reaction liquid formed after the incubation of the sample liquid to be tested to obtain the reaction data of the sample. For example, the measuring device 60 detects the reaction liquid formed after the incubation of the sample liquid to be tested, and calculates the concentration of the component to be tested in the sample through a calibration curve, etc. In some embodiments, the measuring device 60 is separately arranged outside the reaction device.

[0055] In some embodiments, the measuring device 60 can also be an electrical measuring device (such as an impedance measuring mechanism) or a measuring device based on other principles (such as an imaging measuring mechanism).

[0056] The control device is communicatively connected to the pipetting device 10, the sample supply device 20, the reagent supply device 30, the reaction device 40, and the measurement device 60, and is configured to control the pipetting device 10, the sample supply device 20, the reagent supply device 30, the reaction device 40, and the measurement device 60 to perform related operations to complete sample measurement.

[0057] In some embodiments, the control device 60 controls the needle moving mechanism 12 to drive the pipetting needle 11 to move horizontally to the sample supply position 21, and then controls the needle moving mechanism 12 to drive the pipetting needle 11 to descend vertically to a height at which the pipetting needle 11 can aspirate the sample. The control device controls the first power mechanism 13 to drive the pipetting needle 11 to aspirate the sample. After the sample aspiration is completed, the control device controls the pipetting needle 11 to rise vertically and then move horizontally to the sample addition position, and controls the first power mechanism 13 to drive the pipetting needle 11 to discharge the sample into the reaction vessel located at the sample addition position.

[0058] In some embodiments, the control device controls the needle moving mechanism 12 to drive the pipetting needle 11 to move horizontally to the reagent supply position 31, and then controls the needle moving mechanism 12 to drive the pipetting needle 11 to descend vertically to a height at which the pipetting needle can aspirate the reagent. The control device controls the first power mechanism 13 to drive the pipetting needle 11 to aspirate the reagent. After the reagent aspiration is completed, the control device controls the pipetting needle to rise vertically and then move horizontally to the reagent addition position, and controls the first power mechanism 13 to drive the pipetting needle 11 to discharge the reagent into the reaction vessel located at the reagent addition position.

[0059] In some embodiments, the cleaning liquid fills the entire pipeline 15 and a part of the needle tube of the pipetting needle 11. During the above-described discharging operations of discharging the sample and discharging the reagent, the control device controls the first power mechanism 13 to convey at least a part of the cleaning liquid into the needle tube of the pipetting needle 11 to provide a liquid discharging power for the pipetting needle 11; during the above-described liquid aspiration operations of aspirating the sample and aspirating the reagent, the control device controls the first power mechanism 13 to withdraw the cleaning liquid from the needle tube of the pipetting needle 11, so that the needle tube of the pipetting needle 11 has a suction power to complete the liquid aspiration operation of aspirating the sample or the reagent.

[0060] In some embodiments, after completing the above-described operation of discharging the sample or reagent, the control device controls the needle moving mechanism 12 to drive the pipetting needle 11 to move to the cleaning position, and controls the pipetting device to perform a cleaning operation. The cleaning operation includes controlling the first power mechanism 13 to drive the pipetting needle 11 to aspirate air, and after completing the aspiration of air, controlling the first power mechanism 13 to drive the pipetting needle 11 to discharge air and cleaning liquid. In the prior art, when cleaning the pipetting needle 11, the cleaning liquid is continuously discharged from the needle tube of the pipetting needle 11 by the first power mechanism 13, and the purpose of cleaning is achieved by the mass exchange between the cleaning liquid and the foreign matter remaining on the inner wall of the needle tube of the pipetting needle 11. In the present invention, a section of air is aspirated to break the liquid film remaining on the inner wall of the needle tube of the pipetting needle 11, and then when discharging air and cleaning liquid subsequently, it is more conducive to the mass exchange between the cleaning liquid and the foreign matter on the inner wall of the needle tube of the pipetting needle 11, achieving the purpose of strengthening the cleaning and improving the cleaning effect.

[0061] In some embodiments, the control device is further configured to: after the pipetting needle 11 completes discharging the sample or reagent and before the pipetting needle 11 aspirates air, control the first power mechanism 13 to drive the pipetting needle 11 to discharge the cleaning liquid. In this embodiment, since after discharging the reagent or sample, a section of cleaning liquid is discharged first and then air is aspirated. Since after discharging the reagent or sample, the content of foreign matter on the inner wall of the needle tube of the pipetting needle 11 is relatively high, if air is directly aspirated at this time, it is easy to bring foreign matter into the inside of the needle tube and cause contamination; at this time, the concentration of foreign matter on the inner wall of the needle tube is first reduced by discharging the cleaning liquid, preparing for subsequent aspiration of air to break the remaining liquid film, because the reduction of the foreign matter on the inner wall of the needle tube from a high concentration to a low concentration can be quickly completed by the operation of discharging the cleaning liquid, and further reducing the concentration from a low concentration to a concentration meeting the cleaning requirements by discharging the cleaning liquid is relatively difficult compared to reducing the concentration from a high concentration to a low concentration. After reducing the high concentration on the inner wall of the needle tube to a low concentration, the cleaning efficiency can be improved by aspirating air and discharging air and cleaning liquid.

[0062] In some embodiments, the control device is further configured to: after the pipetting needle 11 aspirates air and before the pipetting needle 11 discharges air and cleaning liquid, control the first power mechanism 13 to stop driving for a first preset time. After the first power mechanism 13 stops driving for the first preset time, the air and cleaning liquid in the pipetting needle 11 will change from a fluctuating state to a stable state, which is conducive to the aggregation of foreign matter in the needle tube at this time, and is more conducive to discharging the foreign matter from the needle tube when discharging air and cleaning liquid subsequently, so as to improve the cleaning effect of the inner wall of the needle tube.

[0063] In some embodiments, the control device is further configured to: after the pipette needle 11 completes the discharge of the sample or reagent and before the pipette needle 11 sucks air, when the first power mechanism 13 is controlled to drive the pipette needle 11 to discharge the cleaning liquid, execute: discharge the first part of the cleaning liquid, control the first power mechanism 13 to stop driving for the second preset time, and control the first power mechanism 13 to drive the pipette needle 11 to discharge the second part of the cleaning liquid after the second preset time of stopping driving is completed. After the pipette needle 11 completes the discharge of the sample or reagent and before the pipette needle 11 sucks air, the control device controls the first power mechanism 13 to drive the pipette needle 11 to discharge the cleaning liquid. In the process of discharging the cleaning liquid, the first power mechanism 13 is first controlled to discharge the first part of the cleaning liquid, and then the first power mechanism 13 is controlled to stop driving for the second preset time. After the first power mechanism 13 is controlled to stop driving for the second preset time, the first power mechanism 13 is controlled to drive the pipette needle 11 to discharge the second part of the cleaning liquid. In general, the cleaning liquid that was originally discharged once is divided into two discharges, and a period of time is separated between the first discharge and the second discharge of the cleaning liquid. Of course, those skilled in the art will know that the process of discharging the cleaning liquid can be divided into multiple discharges, not just two. Discharging the cleaning liquid at intervals during the process of discharging the cleaning liquid is conducive to turning the cleaning liquid in the needle tube from a fluctuating state to a stable state, thereby facilitating the aggregation of foreign matter, and improving the efficiency of discharging foreign matter when discharging the cleaning liquid, thereby reducing the concentration of foreign matter in the needle tube.

[0064] In some embodiments, during the process of the pipette needle 11 discharging air and cleaning liquid, the volume of the cleaning liquid discharged by the pipette needle 11 is greater than the volume of air discharged by the pipette needle 11. After the pipette needle 11 absorbs the reagent or sample, a sample section or a reagent section is formed in the needle tube. After discharging this section of reagent or sample, the reagent or sample may form a residue after contacting the inner wall of the needle tube, and the residue contacts the cleaning liquid to form a contaminated cleaning liquid section. When the pipette needle 11 draws air, the contaminated cleaning liquid section will rise inside the pipette needle 11; in order to ensure the cleaning effect, the discharged cleaning liquid must be greater than the air volume in order to achieve the cleaning of the inner wall contaminated by the contaminated cleaning liquid section.

[0065] In some embodiments, the sample analyzer 100 includes a cleaning operation in a first cleaning mode and a cleaning operation in a second cleaning mode, and the volume of the cleaning liquid discharged by the pipetting needle 11 and / or the volume of the aspirated air are different in the cleaning operation in the first cleaning mode and the cleaning operation in the second cleaning mode. The control device is further configured to: after the pipetting needle 11 discharges the first sample or the first reagent, control the cleaning operation of the first cleaning mode to be performed on the pipetting needle 11; after the pipetting needle 11 discharges the second sample or the second reagent, control the cleaning operation of the second cleaning mode to be performed on the pipetting needle 11; wherein the types of the first sample and the second sample are different, or the types of the first reagent and the second reagent are different. Here, taking the sample as an example, the degree of attachment of the sample to the inner wall of the needle tube of the pipetting needle 11 is different, and thus the efficiency of the material exchange between the foreign matter generated by the sample and the cleaning liquid is also different. By setting different cleaning modes, it is beneficial to more precisely clean the inner wall of the pipetting needle. Preferably, for samples or reagents with high material exchange efficiency, a small volume of aspirated air is used; for samples or reagents with low material exchange efficiency, a large volume of aspirated air is used.

[0066] In some embodiments, the cleaning operation further includes that after the pipetting needle 11 finishes discharging air and the cleaning liquid, the control device controls the first power mechanism 13 to drive the pipetting needle 11 to aspirate air, discharge air and the cleaning liquid again. In this embodiment, after the control device controls the first power mechanism 13 to complete driving the pipetting needle 11 to aspirate air, discharge air and the cleaning liquid, aspirating air, discharging air and the cleaning liquid are performed again at the same cleaning position, which is beneficial to fully clean the foreign matter on the inner wall of the needle tube of the pipetting needle 11.

[0067] In some embodiments, the cleaning device 50 further includes an outer wall cleaning mechanism 51 connected by a pipeline, a second power mechanism 54, and a second cleaning liquid supply mechanism 14. The outer wall cleaning mechanism 51 is used to spray the cleaning liquid to clean the outer wall of the pipetting needle 11, the second cleaning liquid supply mechanism 14 is used to supply the cleaning liquid, and the second power mechanism 54 provides the power to drive the cleaning liquid for the outer wall cleaning mechanism 51 to perform the outer wall cleaning. The control device is further configured to, when controlling the pipetting device to perform the cleaning operation, control the second power mechanism 54 to drive the outer wall cleaning mechanism 51 to spray the cleaning liquid to clean the outer wall of the pipetting needle 11. Since the outer wall of the pipetting needle 11 is cleaned while the inner wall of the pipetting needle 11 is being cleaned, cleaning the inner wall and the outer wall of the pipetting needle 11 simultaneously is beneficial to saving the cleaning time of the pipetting needle.

[0068] In some embodiments, the outer wall cleaning mechanism 51 includes at least two liquid outlets, and the at least two liquid outlets are arranged at the same height at annular intervals, and the cleaning position is located inside the annulus, so that the cleaning liquid sprayed from the liquid outlets can contact the outer wall of the pipetting needle 11 when the pipetting needle 11 is located at the cleaning position. By setting two liquid outlets at the same height, the cleaning efficiency of the outer wall of the pipetting needle 11 is improved.

[0069] In some embodiments, the second cleaning liquid supply mechanism 14 and the first cleaning liquid supply mechanism 14 are the same cleaning liquid supply mechanism. The cleaning liquid supply mechanism is respectively connected to the pipetting needle 11 and the outer wall cleaning mechanism 51 through pipelines, and the valves provided on the pipelines are used to control the supply of cleaning liquid from the cleaning liquid supply mechanism to the pipetting needle 11 and the outer wall cleaning mechanism 51. Combining the two cleaning liquid supply mechanisms into one is beneficial to the compact structure of the liquid path system and also beneficial for users to replace the cleaning liquid. At the same time, in some embodiments, the second cleaning liquid supply mechanism 14 and the first cleaning liquid supply mechanism 14 can also be two different cleaning liquid supply mechanisms.

[0070] In some embodiments, the cleaning device 50 further includes a cleaning pool 52 and a waste liquid tank 53. The cleaning liquid discharged from the outer wall cleaning mechanism 51 and the pipetting needle 11 is collected in the cleaning pool 52. A liquid discharge port is provided at the bottom of the cleaning pool 52, and the cleaning device further includes a waste liquid tank 53 connected to the liquid discharge port.

[0071] Embodiment 2:

[0072] The main difference between the sample analyzer provided in this embodiment and that in Embodiment 1 lies in the different ways of providing the cleaning liquid during the cleaning operation, specifically: in Embodiment 1, the cleaning liquid for the cleaning operation comes from inside the needle tube of the pipetting needle 11, while in this embodiment, the cleaning liquid for the cleaning operation is obtained by the pipetting needle 11 sucking from the cleaning liquid supply position 55 into the needle tube of the pipetting needle 11.

[0073] Specifically, in this embodiment, please refer to Figure 4, the sample analyzer 100 includes a pipetting device 10 for aspirating and dispensing samples and / or reagents. The pipetting device 10 includes a pipetting needle 11, a needle moving mechanism 12 for driving the movement of the pipetting needle, and a first power mechanism 13 for providing power for the sample and / or reagent aspiration operation of the pipetting needle 11; a measuring device 60 for measuring a reaction solution made at least of a mixture of a sample and a reagent; a cleaning device 50 provided with a cleaning liquid supply position 55 for providing a cleaning liquid; and a control device communicatively connected at least to the pipetting device 10. The control device is configured to: control the first power mechanism 13 to drive the pipetting needle 11 to aspirate a sample or a reagent and perform a discharging operation of the sample or the reagent to a reaction vessel located at the sample adding position, control the needle moving mechanism 12 to drive the pipetting needle 11 to move to the cleaning device 50, and control the pipetting needle 11 to perform a cleaning operation. The cleaning operation includes controlling the needle moving mechanism 12 to drive the pipetting needle 11 to move to the cleaning liquid supply position 55, controlling the first power mechanism 13 to drive the pipetting needle 11 to aspirate the cleaning liquid provided by the cleaning liquid supply position 55, after the first power mechanism 13 drives the pipetting needle 11 to complete aspirating the cleaning liquid, controlling the first power mechanism 13 to drive the pipetting needle 11 to aspirate air, and after the pipetting needle 11 completes aspirating air, controlling the first power mechanism 13 to drive the pipetting needle 11 to discharge the air and the cleaning liquid. In the present invention, a section of air is aspirated to break the liquid film remaining on the inner wall of the needle tube of the pipetting needle 11, and then when discharging the air and the cleaning liquid, it is more conducive to the mass exchange between the cleaning liquid and foreign matters on the inner wall of the pipetting needle tube, achieving the purpose of strengthening cleaning and improving the cleaning effect.

[0074] In some embodiments, the pipetting device 10 further includes a deionized water supply device and a pipeline. The pipeline connects the deionized water supply device, the first power mechanism 13, and the pipetting needle 11. When performing a liquid aspiration and dispensing operation, the control device controls the first power mechanism 13 to drive the deionized water to move so as to enable the pipetting needle to generate the power for liquid aspiration or discharge. The cleaning liquid provided by the cleaning liquid supply position 55 may be different from or the same as the deionized water. Preferably, the cleaning liquid is different from the deionized water and is an alkaline cleaning agent, which is more conducive to cleaning the inner wall of the pipetting needle tube.

[0075] In some embodiments, the control device is further configured to: after the pipetting needle 11 completes aspirating the cleaning liquid and before the pipetting needle 11 aspirates air, control the needle moving mechanism 12 to move the pipetting needle 11 to a cleaning position, and control the first power mechanism 13 to drive the pipetting needle 11 to discharge a part of the cleaning liquid in the pipetting needle 11.

[0076] In some embodiments, the control device is further configured to control the first power mechanism 13 to stop driving within a first preset time after the pipette needle 11 draws air and before the pipette needle 11 discharges air and cleaning liquid. After the first power mechanism 13 is controlled to stop driving for the first preset time, the air and cleaning liquid in the pipette needle 11 will change from the previous fluctuating state to a stable state, which is conducive to the accumulation of foreign matter in the needle tube, and is more conducive to discharging foreign matter from the needle tube when the air and cleaning liquid are subsequently discharged, so as to improve the cleaning effect of the inner wall of the needle tube.

[0077] In some embodiments, the control device is further configured to: after the pipette needle 11 completes the discharge of the sample or reagent and before the pipette needle 11 draws air, when controlling the first power mechanism 13 to drive the pipette needle to discharge the cleaning liquid, execute: discharge the first part of the cleaning liquid, control the first power mechanism 13 to stop driving within a second preset time, and control the first power mechanism 13 to drive the pipette needle 11 to discharge the second part of the cleaning liquid after completing the second preset time of stopping driving. After the pipette needle 11 has completed the discharge of the sample or reagent and before the pipette needle 11 has sucked air, the control device controls the first power mechanism 13 to drive the pipette needle 11 to discharge the cleaning liquid. In the process of discharging the cleaning liquid, the first power mechanism 13 is first controlled to discharge the first part of the cleaning liquid, and then the first power mechanism 13 is controlled to stop driving for the second preset time. After the first power mechanism 13 is controlled to stop driving for the second preset time, the first power mechanism 13 is controlled to drive the pipette needle 11 to discharge the second part of the cleaning liquid. In general, the cleaning liquid that was originally discharged once is divided into two discharges, and a period of time is separated between the first discharge and the second discharge of the cleaning liquid. Of course, those skilled in the art will know that this process of discharging the cleaning liquid can also be divided into multiple discharges, not limited to two times. Discharging at intervals during the process of discharging the cleaning liquid is conducive to turning the cleaning liquid in the needle tube from a fluctuating state to a stable state, thereby facilitating the aggregation of foreign matter, and is conducive to improving the efficiency of discharging foreign matter when discharging the cleaning liquid, thereby reducing the concentration of foreign matter in the needle tube.

[0078] In addition to the above differences, other parts of the sample analyzer 100 provided in this embodiment can be optimized and designed with reference to the first embodiment, and will not be described in detail here.

[0079] Embodiment three:

[0080] This embodiment provides a control method of a sample analyzer 100 , including steps S10 to S14 .

[0081] like Figure 5 As shown, step S10: controlling the first power mechanism 13 of the sample analyzer 100 to drive the pipette needle 11 of the sample analyzer 100 to perform an operation of aspirating a sample or a reagent;

[0082] Execute step S11: Control the first power mechanism 13 of the sample analyzer 100 to drive the pipetting needle 11 of the sample analyzer 100 to perform the discharge operation of the sample or reagent into the reaction vessel located at the sample addition position.

[0083] In some embodiments, during the operation of aspirating the sample or reagent or the discharge operation, the first power mechanism 13 delivers at least a portion of the cleaning liquid into the needle tube of the pipetting needle 11.

[0084] After the pipetting needle 11 completes the discharge of the sample or the reagent, execute step S12: Control the needle movement mechanism 12 to drive the pipetting needle 11 to move to the cleaning position.

[0085] Control the pipetting needle 11 to perform a cleaning operation, wherein the cleaning operation includes: execute step S13: Control the first power mechanism 13 to drive the pipetting needle 11 to aspirate air.

[0086] Execute step S14: Control the first power mechanism 13 to drive the pipetting needle 11 to discharge air and the cleaning liquid.

[0087] Example 4:

[0088] The main difference between this embodiment and Embodiment 3 lies in the different ways of providing the cleaning liquid during the cleaning operation, specifically: In Embodiment 3, the cleaning liquid for the cleaning operation comes from inside the needle tube of the pipetting needle 11, while in this embodiment, the cleaning liquid for the cleaning operation is obtained by the pipetting needle 11 aspirating the cleaning liquid from the cleaning liquid supply position into the needle tube of the pipetting needle 11.

[0089] Specifically, this embodiment provides a control method for a sample analyzer 100, including steps S20 to S25.

[0090] As Figure 6 shown, step S20: Control the first power mechanism 13 of the sample analyzer 100 to drive the pipetting needle 11 of the sample analyzer 100 to perform the operation of aspirating the sample or reagent.

[0091] Execute step S21: Control the first power mechanism 13 to drive the pipetting needle 11 to perform the discharge operation of the sample or reagent into the reaction vessel located at the sample addition position.

[0092] Execute step S22: Control the needle movement mechanism 12 to drive the pipetting needle 11 to move to the cleaning liquid supply position.

[0093] Execute step S23: Control the first power mechanism 13 to drive the pipetting needle 11 to aspirate the cleaning liquid provided at the cleaning liquid supply position.

[0094] Execute step S24: Control the first power mechanism 13 to drive the pipetting needle to aspirate air.

[0095] Execute step S25: Control the first power mechanism 13 to drive the pipetting needle 11 to discharge air and cleaning liquid at the cleaning position.

[0096] The above are only the preferred embodiments of the present invention, and do not limit the patent scope of the present invention accordingly. Any equivalent structural transformation made by using the content of the specification and drawings of the present invention under the inventive concept of the present invention, or direct / indirect application in other related technical fields is included in the patent protection scope of the present invention.

Claims

1. A sample analyzer, characterized in that, Comprising: A pipetting device for aspirating and dispensing samples and / or reagents, the pipetting device including a pipetting needle, a needle movement mechanism for driving the movement of the pipetting needle, a first power mechanism, a first cleaning liquid supply mechanism for providing cleaning liquid, and a pipeline, the pipeline connecting the first cleaning liquid supply mechanism, the first power mechanism and the pipetting needle, the first power mechanism being used to provide power for the pipetting needle to perform liquid aspiration and liquid discharge operations; A measuring device for measuring a reaction liquid made at least of a mixture of a sample and a reagent; A cleaning device provided with a cleaning position for collecting waste liquid generated by cleaning the pipetting needle; A control device communicatively connected at least to the pipetting device, the control device being configured to: control the first power mechanism to drive the pipetting needle to aspirate a sample or a reagent, perform a discharging operation of the sample or the reagent to a reaction vessel located at a sample addition position, and during the discharging operation, the first power mechanism conveys at least part of the cleaning liquid into the needle tube of the pipetting needle; after the pipetting needle finishes discharging the sample or the reagent, control the needle movement mechanism to drive the pipetting needle to move to the cleaning position, and control the pipetting device to perform a cleaning operation, the cleaning operation including: controlling the first power mechanism to drive the pipetting needle to aspirate air, and controlling the first power mechanism to drive the pipetting needle to discharge the air and the cleaning liquid.

2. The sample analyzer according to claim 1, wherein The control device is further configured to: after the pipetting needle finishes discharging the sample or the reagent and before the pipetting needle aspirates air, control the first power mechanism to drive the pipetting needle to discharge the cleaning liquid.

3. The sample analyzer according to claim 2, wherein The control device is further configured to: after the pipetting needle aspirates air and before the pipetting needle discharges the air and the cleaning liquid, control the first power mechanism to stop driving for a first preset time.

4. The sample analyzer according to claim 2, wherein, The control device is further configured to: when, after the pipetting needle finishes discharging the sample or the reagent and before the pipetting needle aspirates air, control the first power mechanism to drive the pipetting needle to discharge the cleaning liquid, perform: discharging a first part of the cleaning liquid, controlling the first power mechanism to stop driving for a second preset time, and after finishing stopping driving for the second preset time, controlling the first power mechanism to drive the pipetting needle to discharge a second part of the cleaning liquid.

5. The sample analyzer according to claim 1, characterized in that, During the process of the pipetting needle discharging the air and the cleaning liquid, the volume of the cleaning liquid discharged by the pipetting needle is greater than the volume of the air discharged by the pipetting needle.

6. The sample analyzer according to claim 1, wherein The sample analyzer includes a cleaning operation in a first cleaning mode and a cleaning operation in a second cleaning mode, in which the volume of the cleaning liquid discharged by the pipetting needle and / or the volume of the aspirated air are different, the control device is further configured to: after the pipetting needle discharges a first sample or a first reagent, control to perform the cleaning operation in the first cleaning mode on the pipetting needle; after the pipetting needle discharges a second sample or a second reagent, control to perform the cleaning operation in the second cleaning mode on the pipetting needle; wherein the types of the first sample and the second sample are different, or the types of the first reagent and the second reagent are different.

7. The sample analyzer according to any one of claims 1-6, characterized in that, The cleaning operation further includes: after the pipetting needle has completed exhausting air and cleaning liquid, controlling the first power mechanism to drive the pipetting needle to perform air suction, air exhaustion, and cleaning liquid discharge again.

8. The sample analyzer according to any one of claims 1-6, characterized in that, The cleaning device further includes an outer wall cleaning mechanism, a second power mechanism, and a second cleaning liquid supply mechanism connected by pipelines. The outer wall cleaning mechanism is used to spray cleaning liquid to clean the outer wall of the pipetting needle. The second cleaning liquid supply mechanism is used to supply cleaning liquid. The second power mechanism provides the power to drive the cleaning liquid for the outer wall cleaning of the outer wall cleaning mechanism. The control device is further configured to, when controlling the pipetting device to perform a cleaning operation, control the second power mechanism to drive the outer wall cleaning mechanism to spray cleaning liquid to clean the outer wall of the pipetting needle.

9. A sample analyzer, characterized in that, Including: A pipetting device for aspirating and injecting samples and / or reagents. The pipetting device includes a pipetting needle, a needle moving mechanism for driving the movement of the pipetting needle, and a first power mechanism for providing power for the pipetting needle to perform sample and / or reagent aspiration and injection operations. A measuring device for measuring a reaction liquid made of at least a mixture of a sample and a reagent. A cleaning device provided with a cleaning liquid supply position for providing cleaning liquid. A control device communicatively connected to at least the pipetting device. The control device is configured to: control the first power mechanism to drive the pipetting needle to aspirate a sample or a reagent, perform a discharge operation of the sample or the reagent to a reaction container located at a sample addition position, control the needle moving mechanism to drive the pipetting needle to move to the cleaning device, and control the pipetting needle to perform a cleaning operation. The cleaning operation includes controlling the needle moving mechanism to drive the pipetting needle to move to the cleaning liquid supply position, controlling the first power mechanism to drive the pipetting needle to aspirate the cleaning liquid provided by the cleaning liquid supply position, controlling the first power mechanism to drive the pipetting needle to aspirate air, and controlling the first power mechanism to drive the pipetting needle to discharge the air and the cleaning liquid.

10. The sample analyzer according to claim 9, characterized in that, The control device is further configured to, after the pipetting needle has completed aspirating the cleaning liquid and before the pipetting needle aspirates air, control the first power mechanism to drive the pipetting needle to discharge a part of the cleaning liquid in the pipetting needle.

11. The sample analyzer according to claim 10, characterized in that, The control device is further configured to, after the pipetting needle aspirates air and before the pipetting needle discharges the air and the cleaning liquid, control the first power mechanism to stop driving for a first preset time.

12. A control method for a sample analyzer, characterized in that, Including: Controlling the first power mechanism of the sample analyzer to drive the pipetting needle of the sample analyzer to perform an operation of aspirating a sample or a reagent, controlling the first power mechanism of the sample analyzer to drive the pipetting needle of the sample analyzer to perform a discharge operation of the sample or the reagent to a reaction container located at a sample addition position. During the operation of aspirating a sample or a reagent or the discharge operation, the first power mechanism conveys at least part of the cleaning liquid into the needle tube of the pipetting needle. After the pipetting needle has discharged the sample or the reagent, the needle movement mechanism is controlled to drive the pipetting needle to move to the cleaning position, and the pipetting needle is controlled to perform a cleaning operation, which includes: controlling the first power mechanism to drive the pipetting needle to aspirate air, and controlling the first power mechanism to drive the pipetting needle to discharge the air and the cleaning liquid.

13. A control method for a sample analyzer, characterized in that, Including: Controlling the first power mechanism of the sample analyzer to drive the pipetting needle of the sample analyzer to perform an operation of aspirating a sample or a reagent, and controlling the first power mechanism to drive the pipetting needle to perform an operation of discharging the sample or the reagent to a reaction container located at the sample addition position; Controlling the needle movement mechanism to drive the pipetting needle to move to the cleaning liquid supply position, controlling the first power mechanism to drive the pipetting needle to aspirate the cleaning liquid provided at the cleaning liquid supply position, controlling the first power mechanism to drive the pipetting needle to aspirate air, and controlling the first power mechanism to drive the pipetting needle to discharge the air and the cleaning liquid at the cleaning position.

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