Sample analyzer and cleaning control method

Abstract

The embodiment of the invention provides a sample analyzer and a cleaning control method. The sample analyzer controls a first power mechanism through a controller to drive a pipetting needle to execute sample and / or reagent dispensing operation on a reaction container located at a sample adding position; in the dispensing operation process, the first power mechanism conveys the cleaning liquid into a needle tube of the pipetting needle; after the execution of the separate injection operation is completed, controlling a needle moving mechanism to drive the pipetting needle to move from the sample adding position to the cleaning position, and at least controlling a first power mechanism to drive the pipetting needle located at the cleaning position to discharge the cleaning liquid so as to clean the inner wall of the pipetting needle; wherein in the process that the pipetting needle moves from the sample adding position to the cleaning position, the needle moving mechanism at least drives the pipetting needle to do two times of variable motion of acceleration and then deceleration in the horizontal direction, disturbance of cleaning liquid in the needle tube is improved through the variable motion, and therefore the inner wall cleaning effect of the pipetting needle can be effectively enhanced.

Description

Technical Field

[0001] This application relates to the technical field of medical devices, and particularly to a sample analyzer and a cleaning control method thereof. Background Art

[0002] Sample analyzers are widely used in clinical examinations. In a sample analyzer, pipette needles are usually used to add quantitative samples or reagents. During the process of adding samples or reagents using a pipette needle, in order to reduce the probability of the pipette needle carrying pollution sources, the pipette needle needs to be cleaned.

[0003] However, in the related art, the cleaning effect of the pipette needle is not good, increasing the probability of cross - contamination during the process of transferring samples and / or reagents by the pipette needle, thereby reducing the accuracy and reliability of the detection results. Summary of the Invention

[0004] The main purpose of the embodiments of this application is to provide a sample analyzer and a cleaning control method thereof, aiming to improve the cleaning effect of the pipette needle, so as to reduce the probability of the pipette needle carrying pollution sources, and further improve the accuracy and reliability of the sample detection results.

[0005] In a first aspect, the embodiments of this application provide a sample analyzer, including:

[0006] A dispensing device for dispensing samples and / or reagents, and the dispensing device includes a pipette needle, a needle moving mechanism for driving the movement of the pipette needle, and a first power mechanism for providing power for the pipette needle to perform a liquid suction action and / or a liquid discharge action;

[0007] A reaction device provided with reaction positions for placing reaction vessels, and the reaction vessels are used to receive samples and reagents so that the samples and reagents are mixed to form a reaction solution;

[0008] A cleaning device provided with a cleaning position and used for receiving the waste liquid generated during the cleaning of the pipette needle;

[0009] A first cleaning container, which is connected to the first power mechanism and used for storing cleaning liquid;

[0010] A detection device for detecting the reaction solution to obtain detection data;

[0011] A controller, which is at least communicatively connected to the dispensing device and is used for:

[0012] Controlling the first power mechanism to drive the pipette needle to perform a dispensing operation of samples and / or reagents to a reaction vessel located at the sample addition position, and during the dispensing operation, the first power mechanism conveys the cleaning liquid into the needle tube of the pipette needle;

[0013] After the dispensing operation is completed, the needle moving mechanism drives the pipetting needle to move from the sample adding position to the cleaning position, and at least controls the first power mechanism to drive the pipetting needle at the cleaning position to discharge the cleaning liquid, so as to clean the inner wall of the pipetting needle;

[0014] Wherein, during the process of the pipetting needle moving from the sample adding position to the cleaning position, the needle moving mechanism drives the pipetting needle to perform at least two variable speed motions of accelerating first and then decelerating in the horizontal direction.

[0015] In a second aspect, an embodiment of the present application further provides a cleaning control method, which is applied to a sample analyzer. The cleaning control method includes:

[0016] Controlling the first power mechanism of the sample analyzer to drive the pipetting needle of the sample analyzer to perform a dispensing operation of a sample and / or a reagent to a reaction vessel located at the sample adding position, and during the dispensing operation, the first power mechanism conveys the cleaning liquid into the needle tube of the pipetting needle;

[0017] After the dispensing operation is completed, controlling the needle moving mechanism of the dispensing device to drive the pipetting needle of the dispensing device to move from the sample adding position to the cleaning position, and controlling the first power mechanism of the sample analyzer to drive the pipetting needle at the cleaning position to discharge the cleaning liquid, so as to clean the inner wall of the pipetting needle;

[0018] Wherein, during the process of the pipetting needle moving from the sample adding position to the cleaning position, the needle moving mechanism drives the pipetting needle to perform at least two variable speed motions of accelerating first and then decelerating in the horizontal direction.

[0019] In a third aspect, an embodiment of the present application further provides a sample analyzer, including:

[0020] A dispensing device for dispensing a sample and / or a reagent, and the dispensing device includes a pipetting needle, a needle moving mechanism for driving the pipetting needle to move, and a first power mechanism for providing power for the pipetting needle to perform a liquid suction action and / or a liquid discharge action;

[0021] A reaction device provided with a reaction position for placing a reaction vessel, and the reaction vessel is used for receiving a sample and a reagent so that the sample and the reagent are mixed to form a reaction liquid;

[0022] A cleaning device provided with a cleaning position and used for receiving the waste liquid generated during the process of cleaning the pipetting needle;

[0023] A cleaning container for storing the cleaning liquid;

[0024] A second power mechanism connected to the cleaning container and used for conveying the cleaning liquid in the cleaning container to the cleaning position;

[0025] A detection device for detecting the reaction liquid to obtain detection data;

[0026] A controller, at least communicatively connected to the dispensing device, and configured to:

[0027] Control the dispensing device to perform a sample and / or reagent dispensing operation on a reaction vessel located at the sampling position;

[0028] After the dispensing operation is completed, control the needle moving mechanism to drive the pipetting needle to move from the sampling position to the cleaning position;

[0029] After the pipetting needle reaches the cleaning position, control the needle moving mechanism to drive the pipetting needle to stay at the cleaning position, and control the second power mechanism to suck cleaning liquid from the cleaning container and deliver the cleaning liquid to the cleaning position to clean the outer wall of the pipetting needle located at the cleaning position;

[0030] Wherein, during the process of the pipetting needle moving from the sampling position to the cleaning position, the needle moving mechanism drives the pipetting needle to perform at least two variable-speed motions of accelerating first and then decelerating in the horizontal direction.

[0031] As can be seen from the technical solutions provided in the present application above, during the process of the sample analyzer performing sample dispensing or reagent dispensing by the dispensing device, the cleaning liquid will be delivered into the needle tube of the pipetting needle by the first power mechanism. Thus, after the pipetting needle completes the dispensing operation at the sampling position, during the process of moving the pipetting needle from the sampling position to the cleaning position, at least two variable-speed motions of accelerating first and then decelerating are performed, so that the cleaning liquid in the needle tube moves with the pipetting needle to disturb and wash the inner wall of the needle tube, effectively enhancing the exchange between the cleaning liquid and the pollutants attached to the inner wall of the needle tube, or enhancing the penetration effect of the cleaning liquid on the pollutants attached to the inner wall of the needle tube, thereby being beneficial to improving the cleaning effect of the inner wall of the needle tube of the pipetting needle, reducing the probability of the pipetting needle carrying pollution sources, and further improving the accuracy and reliability of the sample detection results.

[0032] Alternatively, based on the fact that the pipetting needle performs at least two variable-speed motions of accelerating first and then decelerating during the process of moving from the sampling position to the cleaning position, the liquid impurities on the outer wall of the pipetting needle tube can be better aggregated, so that when cleaning the outer wall, it is easier to clean the aggregated impurities, improving the cleaning effect of the outer wall of the pipetting needle, reducing the probability of the pipetting needle carrying pollution sources, and further improving the accuracy and reliability of the sample detection results.

[0033] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the disclosure of the embodiments of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for the description of the embodiments will be briefly introduced below. Obviously, the drawings in the following description are some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0035] Figure 1 is a schematic block diagram of a sample analyzer in one embodiment;

[0036] Figure 2 is a schematic layout diagram of a sample analyzer in one embodiment;

[0037] Figure 3 is a schematic diagram of the dispensing device of a sample analyzer in one embodiment;

[0038] Figure 4 is a schematic diagram of the structure for cleaning the pipetting needle by the cooperation of the power mechanism and the cleaning container of a sample analyzer in one embodiment;

[0039] Figure 5 is a schematic diagram of the state change of the pipetting needle of a sample analyzer from the state of performing reagent dispensing operation in one embodiment;

[0040] Figure 6 is a schematic diagram of the first moving mode of the pipetting needle of a sample analyzer moving from the sample adding position to the cleaning position in one embodiment;

[0041] Figure 7 is a schematic diagram of the second moving mode of the pipetting needle of a sample analyzer moving from the sample adding position to the cleaning position in one embodiment;

[0042] Figure 8 is a schematic diagram of the third moving mode of the pipetting needle of a sample analyzer moving from the sample adding position to the cleaning position in one embodiment;

[0043] Figure 9 is a schematic diagram of the state change of the pipetting needle of a sample analyzer for inner wall cleaning in one embodiment;

[0044] Figure 10 is a schematic diagram of the inner wall cleaning of the pipetting needle of a sample analyzer in another embodiment. Detailed implementation manners

[0045] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present application.

[0046] In the description of the present application, unless otherwise clearly defined and limited, the terms "installed", "connected", and "coupled" shall be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral connection; it may be a mechanical connection or an electrical connection; it may be directly connected or indirectly connected through an intermediate medium, and it may be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0047] The flowcharts shown in the accompanying drawings are only illustrative examples, and do not necessarily include all the contents and operations / steps, nor are they necessarily executed in the described order. For example, some operations / steps can also be decomposed, combined, or partially merged, so the actual execution order may be changed according to the actual situation.

[0048] The following will describe in detail some embodiments of the present application in conjunction with the accompanying drawings. Without conflict, the features in the following embodiments and implementation manners can be combined with each other.

[0049] Please refer to Figure 1 , the present application provides a sample analyzer for analyzing a sample to be tested to obtain corresponding analysis results.

[0050] As Figure 1 shown, the sample analyzer 100 includes a dispensing device 10, a sample supply device 20, a reagent supply device 30, a reaction device 40, and a detection device 60. The sample supply device 20 is used to provide the sample to be tested, and the reagent supply device 30 is used to provide a reagent that reacts with the sample. The reaction device 40 is provided with reaction positions for placing reaction vessels and is used to provide an incubation place for the reaction solution in the reaction vessels. The reaction vessel is used to receive the sample and the reagent and provide a reaction place for the sample and the reagent so that the sample and the reagent are mixed to form a reaction solution.

[0051] The dispensing device 10 is used to dispense the sample and / or the reagent. For example, the dispensing device 10 is used to dispense the sample provided by the sample supply device 20 and the reagent provided by the reagent supply device 30 into the reaction vessel placed at a preset operation position so that the sample and the reagent are mixed in the reaction vessel to form a reaction solution.

[0052] The detection device 60 is used to detect the reaction solution to obtain detection data. For example, the detection device 60 is used to measure the reaction solution in the reaction cup or the test sample incubated by the reaction solution to obtain the reaction data of the sample. Optionally, the detection device 60 includes a photometric mechanism, and the photometric mechanism is used to detect the luminescence intensity of the test sample and calculate the concentration of the component to be detected in the sample through a calibration curve. Optionally, the detection device 60 is separately arranged on the periphery of the reaction device 40.

[0053] In another embodiment, the detection device 60 includes an electrical detection mechanism (such as an impedance measurement mechanism) or a detection mechanism based on other principles (such as an imaging measurement mechanism).

[0054] Those skilled in the art should understand that Figure 1 merely an example of the sample analyzer 100, which does not constitute a limitation on the sample analyzer 100. The sample analyzer 100 may include more or fewer components than Figure 1 shown, or combine certain components, or different components. For example, the sample analyzer 100 may further include input / output devices, network access devices, etc.

[0055] Please refer to Figure 2 , in some embodiments, the reaction device 40 has a support portion 401, and at least one reaction site is provided on the support portion 401. The reaction site is used to place a reaction container (such as a reaction cup 4011). The reaction container is used to receive samples and reagents and provide a reaction site for the samples and reagents to mix and form a reaction solution. For example, the reaction container receives the sample obtained by the dispensing device 10 from the sample supply device 20 and the reagent obtained from the reagent supply device 30, so that the sample and the reagent react to form a reaction solution.

[0056] Optionally, the reaction device 40 is also used to incubate the reaction solution in the reaction container.

[0057] Optionally, the support portion 401 of the reaction device 40 may be a reaction disk. As Figure 2 shown, it is arranged as a disk-shaped component and has one or more reaction sites for placing reaction containers. The reaction disk can incubate the reaction solution in the reaction container and can rotate to drive the reaction container placed in the reaction site to rotate, realizing the scheduling of the reaction containers in the reaction disk within a preset area. For example, the reaction container located in the reaction site is scheduled to the position for reagent addition.

[0058] It can be understood that the reaction site for the reaction cup can be provided not only on the reaction disk of the reaction device 40 but also independently of the reaction disk of the reaction device 40. The reaction site being set independently of the reaction disk means that the setting of the reaction site does not interfere with the rotation of the reaction disk itself.

[0059] Please refer to Figures 2 to 3 , in some embodiments, the sample supply device 20 may include a sample distribution module (SDM, Sample Delivery Module) and a front-end track; the sample supply device 20 may also be a sample disk. The sample disk includes a plurality of sample positions for placing samples such as sample tubes. By rotating its disk-shaped component, the sample disk can schedule the sample to the corresponding position. For example, the sample is scheduled to the position where the dispensing device 10 aspirates the sample. The dispensing device 10 is used to aspirate the sample and discharge it into the reaction container to be loaded (such as the reaction cup 4011).

[0060] In some embodiments, the dispensing device 10 is configured to perform the dispensing operation of samples and / or reagents. For example, the dispensing device 10 aspirates the samples supplied by the sample supply device 20 and transfers the samples to the reaction vessels to be loaded with samples.

[0061] Optionally, the dispensing device 10 includes a pipetting needle 101, a needle moving mechanism 102, and a first power mechanism 103. The needle moving mechanism 102 is configured to support the pipetting needle 101 and drive the pipetting needle 101 to move. For example, the pipetting needle 101 performs two-dimensional or three-dimensional movement in space through the two-dimensional or three-dimensional needle moving mechanism 102, so that the pipetting needle 101 can move to aspirate the samples carried by the sample supply device 20 and / or move to aspirate the reagents carried by the reagent supply device 30.

[0062] Exemplarily, the dispensing device 10 has completed the reagent dispensing operation to the reaction vessels of the reaction device 40, that is, the dispensing device 10 has aspirated the reagents from the reagent supply device 30 and discharged at least part of the aspirated reagents into the reaction vessels of the reaction device 40. At this time, if the dispensing device 10 still needs to load samples into the reaction vessels, the pipetting needle 101 moves to the sample tube containing the samples to be tested carried on the sample supply device 20 under the drive of the needle moving mechanism 102, aspirates the samples to be tested under the drive of the first power mechanism 103, and transports the samples to be tested into the reaction vessels of the reaction device 40, so that the samples and reagents react in the reaction vessels to form a reaction solution.

[0063] As Figure 3 shown, in some embodiments, the needle moving mechanism 102 includes a support frame 1021, the support frame 1021 is fixed on a support rod 1022, the support rod 1022 can move vertically and rotate, and the support frame 1021 realizes vertical movement and horizontal rotation under the drive of the support rod 1022. The pipetting needle 101 is arranged on the support frame 1021 and can reach the target position under the drive of the support frame 1021. Exemplarily, the needle moving mechanism 102 further includes a driver 1023 for driving the movement of the support rod 1022, such as the driver is a stepper motor, but is not limited thereto. Optionally, the pipetting needle 101 is detachably connected or fixedly connected to the needle moving mechanism 102.

[0064] In some embodiments, the first power mechanism 103 includes a pipeline 1031 and a power component 1033. Among them, the pipeline 1031 is used to transport the fluid medium. One end of the pipeline 1031 is communicated with the pipetting needle 101, and the other end is communicated with the power component 1033, so as to change the flow direction of the fluid medium in the pipeline 1031 under the action of the power component 1033, so that the pipetting needle 101 can perform the transfer of samples and / or reagents. Among them, the power component 1033 includes but is not limited to syringes, pumps.

[0065] In some embodiments, the sample analyzer 100 further includes a scheduling device (not shown in the figure). The scheduling device is at least used to schedule reaction vessels. Specifically, the scheduling device can grasp the target object and drive the target object to move in a two-dimensional or three-dimensional space to achieve the scheduling of the target object. The target object includes, but is not limited to, reaction vessels. For example, the scheduling device schedules the reaction vessel to the sample position in the sample analyzer, so that the sample dispensing device 10 performs a sample adding operation on the reaction vessel placed at the sample position. Or, the scheduling device schedules the reaction vessel to the reagent position in the sample analyzer, so that the reagent dispensing device 10 performs a reagent adding operation on the reaction vessel placed at the reagent position.

[0066] In some embodiments, the sample analyzer 100 further includes a magnetic separation device 80, which is used to perform magnetic separation cleaning on the reaction solution to extract magnetic particles enriched with the analyte in the reaction solution and clean the impurities attached to the surface of the magnetic particles, so as to improve the purity of the analyte in the test sample and further improve the accuracy of the sample detection result.

[0067] After the sample and the reagent react to form a reaction solution, there are impurities and effective components such as the analyte in the reaction solution. The effective components in the reaction solution, that is, the analyte, can be extracted by performing magnetic separation on the reaction solution through the magnetic separation device 80. At the same time, in order to facilitate the understanding of the names of each stage of the sample and the reagent, the names of each stage of the sample and the reagent are described in detail here: the sample and the reagent in the reaction vessel after being mixed are called the reaction solution, also called the mixture. The reaction device 40 can perform an incubation operation on the reaction solution in the reaction vessel to enable the sample and the reagent to react fully. At this time, the reaction solution in the reaction vessel after full reaction includes the analyte and impurities. Among them, the reaction solution refers to the substance formed after the sample and the reagent are mixed, regardless of the ratio and concentration of the sample and the reagent, and is all called the reaction solution here. The incubated reaction solution presents in the reaction vessel in the form of the analyte and impurities. The impurities can be substances that have not reacted fully, by-products generated by side reactions, or other substances that affect the detection of the detection device 60, etc., or a combination of at least two of the above. The magnetic separation device 80 cleans the analyte and impurities in the reaction vessel to better remove the impurities in the reaction vessel and retain the analyte in the reaction vessel. The detection device 60 can detect the analyte in the reaction solution carried in the reaction vessel to obtain various parameters of the corresponding detection items of the sample.

[0068] Please refer to Figure 4, in some embodiments, the sample analyzer 100 further includes a cleaning device 50 and a cleaning container 90. The cleaning device 50 is provided with a cleaning position and is used to receive the waste liquid generated during the cleaning of the pipetting needle 101. The cleaning container 90 is used to store the cleaning liquid, and the cleaning container 90 is connected to the power mechanism to transport the cleaning liquid in the cleaning container 90 to clean the pipetting needle.

[0069] It can be understood that the cleaning container 90 can be one or more, and the power mechanism can also be one or more. Each power mechanism can correspond to one cleaning container 90, or multiple power mechanisms are connected to the same cleaning container 90 and share the same cleaning container 90.

[0070] For example, the cleaning container 90 includes a first cleaning container, and the power mechanism includes a first power mechanism 102. The first power mechanism 102 is connected to the first cleaning container and is used to drive the pipetting needle to perform sample and / or reagent dispensing, and is also used to transport the cleaning liquid in the cleaning container 90 to clean the pipetting needle.

[0071] For another example, the cleaning of the pipetting needle includes inner wall cleaning and outer wall cleaning. The cleaning container 90 includes a first cleaning container, and the power mechanism includes a first power mechanism 102 and a second power mechanism. Both the first power mechanism 102 and the second power mechanism are connected to the first cleaning container.

[0072] And the first power mechanism 102 is used to drive the pipetting needle to perform sample and / or reagent dispensing, and is also used to transport the cleaning liquid in the first cleaning container to clean the inner wall of the pipetting needle. The second power mechanism 102 is used to transport the cleaning liquid in the first cleaning container to clean the outer wall of the pipetting needle.

[0073] For yet another example, the cleaning container 90 includes a first cleaning container and a second cleaning container, and the power mechanism includes a first power mechanism 102 and a second power mechanism. The first power mechanism 102 is connected to the first cleaning container and is used to drive the pipetting needle to perform sample and / or reagent dispensing, and is also used to transport the cleaning liquid in the first cleaning container to clean the inner wall of the pipetting needle. The second power mechanism is connected to the second cleaning container and is used to transport the cleaning liquid in the second cleaning container to clean the outer wall of the pipetting needle.

[0074] It can be understood that the first cleaning container and the second cleaning container can be two different cleaning tanks in the cleaning container 90, or two independent containers, which are not limited herein.

[0075] Such as Figure 1As shown, in some embodiments, the sample analyzer 100 further includes a controller 70. The controller 70 is communicatively connected to the dispensing device 10, the sample supply device 20, the reagent supply device 30, the reaction device 40, and the detection device 60 to control at least one of the dispensing device 10, the sample supply device 20, the reagent supply device 30, the reaction device 40, and the detection device 60 to complete a preset operation. For example, controlling the dispensing device 10 to complete the dispensing operation of the sample and / or reagent, or controlling the sample supply device 20 to complete the sample supply, or controlling the magnetic separation device 80 to complete the magnetic separation and cleaning of the reaction solution.

[0076] It can be understood that there may be one or more controllers 70, and the controller 70 may be disposed in at least any one of the dispensing device 10, the sample supply device 20, the reagent supply device 30, the reaction device 40, and the detection device 60, or may be independently disposed, which is not limited herein.

[0077] In some embodiments, the controller 70 at least includes a processor 701, a memory 702, a communication interface (not shown in the figure), and an I / O interface (not shown in the figure). The processor 701, the memory 702, the communication interface, and the I / O interface communicate through a bus. The processor 701 may be a central processing unit (CPU), and the processor may also be other general-purpose processors, digital signal processors (DSPs), application-specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. Among them, the general-purpose processor may be a microprocessor or the processor may also be any conventional processor, etc.

[0078] The memory 702 stores various computer programs for the processor 701 to execute, such as operating systems and application programs, as well as the data required to execute these computer programs. During the analysis of the sample to be tested, any data that needs to be locally stored can be stored in the memory 702. The I / O interface includes, but is not limited to, serial interfaces such as USB, IEEE1394, or RS-232C, parallel interfaces such as SCSI, IDE, or IEEE1284, and analog signal interfaces composed of D / A converters and converters, etc. An input component is connected to the I / O interface. The user can directly input data to the controller 70 using the input component, and the input component includes, but is not limited to, a keyboard, a mouse, a touch screen, or control buttons. The display component can be communicatively connected to the controller 70 through the I / O interface for relevant information prompting. The communication interface can be an interface of any currently known communication protocol. The communication interface communicates with the outside world through a network, and the controller 70 can transmit data with any component connected through this network in a preset communication protocol.

[0079] In some embodiments, the controller 70 is at least used for:

[0080] Controlling the first power mechanism 103 to drive the pipetting needle 101 to perform the dispensing operation of the sample and / or reagent to the reaction vessel located at the sample addition position. During the dispensing operation, the first power mechanism 103 transports the cleaning liquid into the needle tube of the pipetting needle 101;

[0081] After the dispensing operation is completed, controlling the needle movement mechanism 102 to drive the pipetting needle 101 to move from the sample addition position to the cleaning position, and at least controlling the first power mechanism 103 to drive the pipetting needle 101 located at the cleaning position to discharge the cleaning liquid to clean the inner wall of the pipetting needle 101;

[0082] Wherein, during the process of the pipetting needle 101 moving from the sample addition position to the cleaning position, the needle movement mechanism 102 drives the pipetting needle 101 to perform at least two variable-speed movements of accelerating first and then decelerating in the horizontal direction.

[0083] It can be understood that during the process of the pipetting needle 101 moving from the sample addition position to the cleaning position, the movement trajectory of the pipetting needle 101 on the horizontal plane can be arc-shaped or linear, which is not limited herein.

[0084] Optionally, during the process of the pipetting needle 101 moving from the sample addition position to the cleaning position, the movement trajectory of the pipetting needle 101 on the horizontal plane is arc-shaped. By driving the pipetting needle 101 to move in an arc, a certain centripetal force is given to the cleaning liquid in the pipetting needle 101, so as to effectively enhance the disturbance effect of the cleaning liquid on the inner wall of the needle tube of the pipetting needle 101.

[0085] Exemplarily, the cleaning of the pipetting needle includes inner wall cleaning and outer wall cleaning. In this embodiment, after the pipetting needle 101 performs the sample dispensing operation, the cleaning of the inner wall of the pipetting needle is taken as an example at least at the cleaning position for illustration.

[0086] Before performing the reagent dispensing operation or during the execution of the reagent dispensing operation, the first power mechanism 103 sucks the cleaning liquid from the first cleaning container to inject and store the cleaning liquid into the pipeline and / or the power assembly connected to the pipetting needle 101. Thus, when the dispensing device 10 performs reagent dispensing, the needle moving mechanism 102 is controlled to drive the pipetting needle 101 to move to the corresponding operation position, and at the corresponding operation position, the first power mechanism 103 is controlled to change the flow direction of the cleaning liquid stored in the pipeline and / or the power assembly, so as to suck and discharge the reagent at the corresponding operation position, thereby completing the reagent dispensing operation.

[0087] Please refer to Figure 5 , the operation positions include a reagent suction position for performing reagent suction and a sample addition position for adding samples and / or reagents. During the reagent dispensing process, the needle moving mechanism 102 first drives the pipetting needle 101 to move to the reagent suction position, and controls the first power mechanism 103 to drive the cleaning liquid in the pipeline to flow away from one end of the pipetting needle 101, so as to drive the pipetting needle 101 to suck the reagent provided by the reagent supply device 30 at the reagent suction position. After the reagent suction is completed, the needle moving mechanism 102 first drives the pipetting needle 101 to move to the sample addition position, and controls the first power mechanism 103 to drive the cleaning liquid in the pipeline to flow towards one end of the pipetting needle 101, so as to drive the pipetting needle 101 to discharge the reagent to the reaction container at the sample addition position to complete the reagent dispensing. During the reagent discharge process at the sample addition position, the first power mechanism 103 drives the cleaning liquid in the pipeline to flow towards the pipetting needle 101, so as to transport the cleaning liquid into the needle tube of the pipetting needle 101.

[0088] After completing the reagent dispensing operation, the needle moving mechanism 102 drives the pipetting needle 101 to move from the sample addition position to the cleaning position. During the movement, the moving mechanism 102 drives the pipetting needle 101 to perform at least two variable speed motions of accelerating first and then decelerating in the horizontal direction. After reaching the cleaning position, at least the first power mechanism 103 is controlled to suck the cleaning liquid from the first cleaning container and discharge the cleaning liquid to the pipetting needle 101 located at the cleaning position to clean the inner wall of the pipetting needle 101.

[0089] During the process of sample dispensing or reagent dispensing by the sample analyzer 100 in the dispensing device 10, the cleaning liquid is conveyed into the syringe of the pipetting needle 101. After the pipetting needle 101 completes the dispensing operation at the sample addition position, during the process of moving the pipetting needle from the sample addition position to the cleaning position, it undergoes at least two variable-speed motions of accelerating first and then decelerating. As a result, the cleaning liquid in the syringe of the pipetting needle 101 undergoes variable-speed motion along with the pipetting needle 101 to disturb and wash the inner wall of the syringe, effectively enhancing the exchange between the cleaning liquid and the contaminants adhering to the inner wall of the syringe, or enhancing the penetration effect of the cleaning liquid on the contaminants adhering to the inner wall of the syringe. This is conducive to improving the cleaning effect of the inner wall of the pipetting needle, reducing the probability of the pipetting needle 101 carrying pollution sources, and further improving the accuracy and reliability of the sample detection results.

[0090] It can be understood that during the horizontal movement of the pipetting needle 101 from the sample addition position to the cleaning position, during the process of at least two variable-speed motions of accelerating first and then decelerating, it can stay once in the horizontal direction or not stay, which is not limited here.

[0091] In some embodiments, during the process of the pipetting needle 101 moving from the sample addition position to the cleaning position, the controller 70 is further configured to: control the needle moving mechanism 102 to drive the pipetting needle 101 to stay at least once in the horizontal direction, that is, the pipetting needle 101 has at least one stop position during the process of moving from the sample addition position to the cleaning position, and when the pipetting needle 101 moves to the stop position, it stays at the stop position.

[0092] Optionally, during the process of the pipetting needle 101 moving from the sample addition position to the stop position, it undergoes at least one variable-speed motion of accelerating first and then decelerating in the horizontal direction, and during the process of moving from the stop position to the cleaning position, it undergoes at least one variable-speed motion of accelerating first and then decelerating in the horizontal direction.

[0093] In some embodiments, during the process of the controller 70 controlling the needle moving mechanism 102 to drive the pipetting needle 101 from the sample addition position to the cleaning position, it performs:

[0094] Control the needle moving mechanism 102 to drive the pipetting needle 101 to move from the sample addition position along the first direction on the horizontal plane through the cleaning position to the first stop position, and stay at the first stop position;

[0095] After the staying time of the pipetting needle 101 reaches the first preset duration, control the needle moving mechanism 102 to drive the pipetting needle 101 to move from the first stop position along the second direction opposite to the first direction to the cleaning position on the horizontal plane.

[0096] Please refer to Figure 6, Exemplarily, taking the movement trajectory of the pipetting needle 101 as an arc trajectory as an example for illustration, there is a first stop position on the movement trajectory of the pipetting needle 101 from the sample addition position to the cleaning position. Among them, the horizontal distance between the sample addition position and the stop position is the first distance, and the horizontal distance between the sample addition position and the cleaning position is the second distance, and the first distance is greater than the second distance.

[0097] During the process of the pipetting needle 101 moving from the sample addition position to the cleaning position, the pipetting needle 101 moves on the horizontal plane from the sample addition position along the first direction, passes through the cleaning position, reaches the first stop position farther away from the sample addition position, and stays at the first stop position to increase the disturbance contact time between the cleaning liquid and impurities in the pipetting needle 101 and improve the inner wall cleaning effect of the pipetting needle. After the residence time of the pipetting needle 101 reaches the first preset duration, the control needle movement mechanism 102 is controlled to drive the pipetting needle 101 to move on the horizontal plane from the first stop position along the second direction opposite to the first direction to the cleaning position, so as to perform inner wall cleaning at the cleaning position.

[0098] In some embodiments, the sample analyzer 100 further includes a second power mechanism, which is connected to the first cleaning container and is used to transport the cleaning liquid in the first cleaning container to perform outer wall cleaning on the pipetting needle 101 located at the cleaning position.

[0099] Optionally, the sample analyzer 100 further includes a second power mechanism and a second cleaning container. The second cleaning container is used to store the cleaning liquid. The second power mechanism is connected to the second cleaning container and is used to transport the cleaning liquid in the second cleaning container to perform outer wall cleaning on the pipetting needle 101 located at the cleaning position.

[0100] Exemplarily, the cleaning of the pipetting needle 101 includes inner wall cleaning and outer wall cleaning. In this embodiment, the inner wall cleaning and outer wall cleaning of the pipetting needle 101 are powered by two different power mechanisms. These two power mechanisms can be connected to the same cleaning container to provide cleaning liquid through the same cleaning container, or two different power mechanisms can be respectively connected to different cleaning containers to provide cleaning liquid through different cleaning containers respectively.

[0101] In some embodiments, the controller 70 is further used to: control the needle movement mechanism 102 to drive the pipetting needle 101 to move on the horizontal plane along the first direction from the sample addition position through the cleaning position to the first transfer position;

[0102] After the pipetting needle 101 moves to the first transfer position, the control needle movement mechanism 102 drives the pipetting needle 101 to stay at the first transfer position, and controls the first power mechanism 103 to transport the cleaning liquid to the first transfer position and / or controls the second power mechanism to transport the cleaning liquid to the first transfer position to perform the first cleaning operation on the pipetting needle 101;

[0103] After the first cleaning operation is completed, the control needle moving mechanism 102 drives the pipetting needle 101 to move from the first transfer position to the cleaning position in the horizontal plane along a second direction opposite to the first direction;

[0104] After the pipetting needle 101 moves to the cleaning position, the control needle moving mechanism 102 drives the pipetting needle 101 to stay at the cleaning position, and at least controls the first power mechanism 103 to convey cleaning liquid to the cleaning position to perform a second cleaning operation on the pipetting needle 101.

[0105] Please refer to Figure 7 , for example, taking the movement trajectory of the pipetting needle 101 as an arc trajectory for illustration, there is a first transfer position on the movement trajectory of the pipetting needle 101 from the sample addition position to the cleaning position. Among them, the horizontal distance between the sample addition position and the transfer position is the third distance, the horizontal distance between the sample addition position and the cleaning position is the fourth distance, and the third distance is greater than the fourth distance.

[0106] The needle moving mechanism 102 drives the pipetting needle 101 to perform at least one variable speed movement of accelerating first and then decelerating along the first direction from the sample addition position in the horizontal plane, passing through the cleaning position and moving to the first transfer position, and staying at the first transfer position.

[0107] After the pipetting needle 101 stays at the first transfer position, control the first power mechanism 103 to suck cleaning liquid from the corresponding cleaning container and convey the cleaning liquid to the first transfer position to clean the inner wall of the pipetting needle 101, and / or control the second power mechanism to suck cleaning liquid from the corresponding cleaning container and convey the cleaning liquid to the first transfer position to clean the outer wall of the pipetting needle 101.

[0108] By staying at the first transfer position, the variable speed effect of the pipetting needle is improved, making the disturbance effect of the cleaning liquid in the needle tube of the pipetting needle 101 on the inner wall of the pipetting needle better. At the same time, during the variable speed movement of the pipetting needle 101, the fluid impurities on the outer wall of the pipetting needle can be aggregated, facilitating the cleaning of the outer wall.

[0109] After the pipetting needle 101 is cleaned at the first transfer position, the needle moving mechanism 102 drives the pipetting needle 101 to perform at least one variable speed movement of accelerating first and then decelerating along a second direction opposite to the first direction from the first transfer position to the cleaning position, and stay at the cleaning position, and at least control the first power mechanism 103 to convey cleaning liquid to the cleaning position to clean the inner wall of the pipetting needle 101. Through at least two cleanings, the cleaning effect of the pipetting needle can be effectively improved.

[0110] Optionally, after the pipetting needle reaches the cleaning position, the second power mechanism is also controlled to convey cleaning liquid to the cleaning position to clean the outer wall of the pipetting needle 101.

[0111] In some embodiments, during the process of the controller controlling the needle moving mechanism 102 to drive the pipetting needle 101 to move from the sample addition position to the cleaning position, the following operations are performed:

[0112] The needle moving mechanism 102 drives the pipetting needle 101 to perform a variable-speed motion of accelerating first and then decelerating at least once along a preset direction on a horizontal plane from the sample addition position until the pipetting needle 101 moves to the second transfer position;

[0113] After the pipetting needle 101 reaches the second transfer position, the needle moving mechanism 102 drives the pipetting needle 101 to continue to perform a variable-speed motion of accelerating first and then decelerating at least once along the preset direction from the second transfer position until the pipetting needle 101 moves to the cleaning position.

[0114] Please refer to Figure 8 , taking the moving trajectory of the pipetting needle 101 as an arc trajectory as an example for illustration. There is a second transfer position on the moving trajectory of the pipetting needle 101 from the sample addition position to the cleaning position. The second transfer position is located between the sample addition position and the cleaning position. During the process of the pipetting needle 101 moving from the sample addition position to the cleaning position, it first moves from the sample addition position to the second transfer position, and during the moving process, it performs a variable-speed motion of accelerating first and then decelerating at least once along a preset direction on a horizontal plane from the sample addition position until the pipetting needle 101 moves to the second transfer position. After the pipetting needle 101 reaches the second transfer position, the needle moving mechanism 102 drives the pipetting needle 101 to continue to perform a variable-speed motion of accelerating first and then decelerating at least once in the same direction from the second transfer position until the pipetting needle 101 moves to the cleaning position, so as to at least clean the inner wall of the pipetting needle at the cleaning position.

[0115] Among them, the pipetting needle 101 may or may not stay at the second transfer position, and this is not limited herein.

[0116] Optionally, the controller 70 is further configured to: after the pipetting needle 101 moves to the second transfer position, control the needle moving mechanism 102 to drive the pipetting needle 101 to stay at the second transfer position;

[0117] After the residence time of the pipetting needle 101 reaches the second preset time period, control the needle moving mechanism 102 to drive the pipetting needle 101 to move from the second transfer position in the same direction to the cleaning position.

[0118] Exemplarily, by staying at the second transfer position, the variable-speed effect of the pipetting needle is improved, so that the cleaning liquid in the needle tube of the pipetting needle 101 has a better disturbing effect on the inner wall of the pipetting needle. At the same time, during the variable-speed movement of the pipetting needle 101, the fluid impurities on the outer wall of the pipetting needle can be aggregated, which is convenient for cleaning the outer wall.

[0119] Optionally, the controller 70 is further configured to: after the pipetting needle 101 stays at the second transfer position, control the first power mechanism 103 to convey cleaning liquid to the second transfer position and / or control the second power mechanism to convey cleaning liquid to the second transfer position, so as to perform a third cleaning operation on the pipetting needle 101;

[0120] After the third cleaning operation is completed, control the needle moving mechanism 102 to drive the pipetting needle 101 to move from the second transfer position to the cleaning position along a first direction on a horizontal plane;

[0121] After the pipetting needle 101 moves to the cleaning position, at least control the first power mechanism 103 to convey cleaning liquid to the cleaning position, so as to perform a fourth cleaning operation on the pipetting needle 101.

[0122] Exemplarily, by staying at the second transfer position, the speed change effect of the pipetting needle is improved, so that the cleaning liquid in the needle tube of the pipetting needle 101 has a better disturbing effect on the inner wall of the pipetting needle. At the same time, during the variable-speed movement of the pipetting needle 101, fluid impurities on the outer wall of the pipetting needle can be aggregated, which is convenient for cleaning the outer wall.

[0123] After the pipetting needle 101 stays at the second transfer position, control the first power mechanism 103 to suck cleaning liquid from the corresponding cleaning container and convey the cleaning liquid to the second transfer position to clean the inner wall of the pipetting needle 101, and / or control the second power mechanism to suck cleaning liquid from the corresponding cleaning container and convey the cleaning liquid to the second transfer position to clean the outer wall of the pipetting needle 101.

[0124] After the pipetting needle 101 stays at the cleaning position, at least control the first power mechanism 103 to suck cleaning liquid from the corresponding cleaning container and convey the cleaning liquid to the cleaning position to clean the inner wall of the pipetting needle 101. Optionally, it may also be that after the pipetting needle 101 stays at the cleaning position, control the second power mechanism to suck cleaning liquid from the corresponding cleaning container and convey the cleaning liquid to the cleaning position to clean the outer wall of the pipetting needle 101. By performing cleaning multiple times, the cleaning effect of the pipetting needle 101 can be better.

[0125] In some embodiments, the cleaning device 50 holds cleaning liquid. During the process of the controller 70 controlling the first power mechanism 103 to drive the pipetting needle 101 located at the cleaning position to discharge the cleaning liquid, the following operations are performed:

[0126] Control the first power mechanism 103 to drive the pipetting needle 101 located at the cleaning position to perform a liquid suction action to suck the cleaning liquid held by the cleaning device 50;

[0127] After the liquid suction action is completed, control the first power mechanism 103 to drive the pipetting needle 101 to perform a liquid discharge action to discharge at least part of the cleaning liquid sucked by the liquid suction action.

[0128] Please refer toFigure 9 When the cleaning device 50 holds the cleaning liquid, discharging the cleaning liquid to clean the inner wall of the pipetting needle 101 can be achieved by driving the pipetting needle 101 at the cleaning position to perform a liquid suction action through the first power mechanism 103 to suck the cleaning liquid held in the cleaning device 50. After the liquid suction ends, the first power mechanism 103 is controlled to drive the pipetting needle 101 to perform a liquid discharge action to discharge at least part of the cleaning liquid sucked by the liquid suction action, so that the cleaning liquid held in the cleaning device 50 cleans the inner wall of the pipetting needle 101.

[0129] In some embodiments, during the process of the controller 70 controlling the first power mechanism 103 to drive the pipetting needle 101 at the cleaning position to discharge the cleaning liquid, the following operations are performed:

[0130] Control the first power mechanism 103 to suck the cleaning liquid from the first cleaning liquid container and convey the cleaning liquid to the pipetting needle 101, so as to discharge the cleaning liquid through the pipetting needle 101.

[0131] Please refer to Figure 10 For cleaning the inner wall of the pipetting needle, it can also be achieved by the first power mechanism 103 sucking the cleaning liquid from the first cleaning liquid container and conveying the cleaning liquid to the pipetting needle 101, so as to discharge the cleaning liquid through the pipetting needle 101, thereby using the cleaning liquid in the first cleaning liquid container to clean the inner wall of the pipetting needle 101.

[0132] In some embodiments, the controller 70 is used for: controlling the dispensing device 10 to perform the dispensing operation of the sample and / or reagent to the reaction container at the sample adding position; after the dispensing operation is completed, controlling the needle moving mechanism 102 to drive the pipetting needle 101 to move from the sample adding position to the cleaning position; after the pipetting needle reaches the cleaning position, controlling the needle moving mechanism 102 to drive the pipetting needle 101 to stay at the cleaning position, and controlling the second power mechanism to suck the cleaning liquid from the cleaning container 90 and convey the cleaning liquid to the cleaning position to perform external wall cleaning on the pipetting needle 101 at the cleaning position; wherein, during the process of the pipetting needle 101 moving from the sample adding position to the cleaning position, the needle moving mechanism 102 at least drives the pipetting needle 101 to perform two variable speed motions of accelerating first and then decelerating in the horizontal direction.

[0133] Please refer to Figure 4 Exemplarily, the cleaning of the pipetting needle includes inner wall cleaning and outer wall cleaning. In this embodiment, taking the case where the pipetting needle 101 performs the dispensing operation of the sample and at least performs external wall cleaning of the pipetting needle at the cleaning position as an example for illustration.

[0134] After the pipetting needle 101 completes the dispensing operation, the needle moving mechanism 102 drives the pipetting needle 101 to move from the sampling position to the cleaning position and stay at the cleaning position. During the outer wall cleaning process, the controller 70 controls the second power mechanism to suck the cleaning liquid from the cleaning container 90 and transport the cleaning liquid to the cleaning position of the cleaning device 50 to clean the outer wall of the pipetting needle 101 located at the cleaning position; wherein, during the process of the pipetting needle 101 moving from the sampling position to the cleaning position, the needle moving mechanism 102 drives the pipetting needle 101 to perform at least two variable speed motions of accelerating first and then decelerating in the horizontal direction.

[0135] Based on the fact that the pipetting needle makes at least two variable speed motions of accelerating first and then decelerating during the process of moving from the sampling position to the cleaning position, the liquid impurities on the outer wall of the needle tube of the pipetting needle 101 can be better aggregated. Therefore, during the outer wall cleaning, it is easier to clean the aggregated impurities, improving the outer wall cleaning effect of the pipetting needle 101, reducing the probability of the pipetting needle 101 carrying pollution sources, and further improving the accuracy and reliability of the sample detection results.

[0136] The following will describe the cleaning control method provided by the embodiments of the present application in combination with the working principle of the sample analyzer 100.

[0137] The embodiments of the present application also provide a cleaning control method applied to the aforementioned sample analyzer 100, and the method includes:

[0138] Controlling the first power mechanism of the sample analyzer to drive the pipetting needle of the sample analyzer to perform the dispensing operation of the sample and / or reagent to the reaction container located at the sampling position, and during the dispensing operation, the first power mechanism transports the cleaning liquid into the needle tube of the pipetting needle;

[0139] After the dispensing operation is completed, controlling the needle moving mechanism of the dispensing device to drive the pipetting needle of the dispensing device to move from the sampling position to the cleaning position, and controlling the first power mechanism of the sample analyzer to drive the pipetting needle located at the cleaning position to discharge the cleaning liquid to clean the inner wall of the pipetting needle;

[0140] Wherein, during the process of the pipetting needle moving from the sampling position to the cleaning position, the needle moving mechanism drives the pipetting needle to perform at least two variable speed motions of accelerating first and then decelerating in the horizontal direction.

[0141] In some embodiments, during the process of the pipetting needle moving from the sampling position to the cleaning position, the method further includes: controlling the needle moving mechanism to drive the pipetting needle to stay at least once in the horizontal direction.

[0142] In some embodiments, during the process of controlling the needle moving mechanism to drive the pipetting needle to move from the sampling position to the cleaning position, the method further includes:

[0143] Control the needle moving mechanism to drive the pipetting needle to move on a horizontal plane from the sample adding position along a first direction through the cleaning position to a first stop position, and stop at the first stop position;

[0144] After the residence time of the pipetting needle reaches a first preset time, control the needle moving mechanism to drive the pipetting needle to move on a horizontal plane from the first stop position along a second direction opposite to the first direction to the cleaning position.

[0145] In some embodiments, the sample analyzer further includes a second power mechanism, the second power mechanism is connected to the first cleaning container, and is used to transport the cleaning liquid in the first cleaning container to perform an outer wall cleaning on the pipetting needle located at the cleaning position;

[0146] Alternatively, the sample analyzer further includes a second power mechanism and a second cleaning container, the second cleaning container is used to store the cleaning liquid, the second power mechanism is connected to the second cleaning container, and is used to transport the cleaning liquid in the second cleaning container to perform an outer wall cleaning on the pipetting needle located at the cleaning position.

[0147] In some embodiments, during the process of the pipetting needle moving from the sample adding position to the cleaning position, the method further includes:

[0148] Control the needle moving mechanism to drive the pipetting needle to move on a horizontal plane along a first direction from the sample adding position through the cleaning position to a first transfer position;

[0149] After the pipetting needle moves to the first transfer position, control the needle moving mechanism to drive the pipetting needle to stay at the first transfer position, and control the first power mechanism to transport the cleaning liquid to the first transfer position and / or control the second power mechanism to transport the cleaning liquid to the first transfer position, so as to perform a first cleaning operation on the pipetting needle;

[0150] After the first cleaning operation is completed, control the needle moving mechanism to drive the pipetting needle to move on a horizontal plane along a second direction opposite to the first direction from the first transfer position to the cleaning position;

[0151] After the pipetting needle moves to the cleaning position, control the needle moving mechanism to drive the pipetting needle to stay at the cleaning position, and at least control the first power mechanism to transport the cleaning liquid to the cleaning position, so as to perform a second cleaning operation on the pipetting needle.

[0152] In some embodiments, the control of the needle moving mechanism to drive the pipetting needle to move from the sample adding position to the cleaning position includes:

[0153] Control the needle moving mechanism to drive the pipetting needle to perform at least one variable-speed motion of accelerating first and then decelerating along a preset direction on a horizontal plane from the sample adding position until the pipetting needle moves to the second transfer position;

[0154] After the pipetting needle reaches the second transfer position, control the needle moving mechanism to drive the pipetting needle to continue to perform at least one variable-speed motion of accelerating first and then decelerating along the preset direction from the second transfer position until the pipetting needle moves to the cleaning position.

[0155] In some embodiments, the method further includes: after the pipetting needle moves to the second transfer position, controlling the needle moving mechanism to drive the pipetting needle to stay at the second transfer position;

[0156] After the residence time of the pipetting needle reaches a second preset time length, control the needle moving mechanism to drive the pipetting needle to move from the second transfer position in the same direction to the cleaning position.

[0157] In some embodiments, the method further includes: after the pipetting needle stays at the second transfer position, and controlling the first power mechanism to convey cleaning liquid to the second transfer position and / or controlling the second power mechanism to convey cleaning liquid to the second transfer position to perform a third cleaning operation on the pipetting needle;

[0158] After the third cleaning operation is completed, control the needle moving mechanism to drive the pipetting needle to move from the second transfer position to the cleaning position along the first direction on a horizontal plane;

[0159] After the pipetting needle moves to the cleaning position, at least control the first power mechanism to convey cleaning liquid to the cleaning position to perform a fourth cleaning operation on the pipetting needle.

[0160] In some embodiments, the cleaning device holds cleaning liquid, and the controlling the first power mechanism to drive the pipetting needle located at the cleaning position to discharge the cleaning liquid includes:

[0161] Control the first power mechanism to drive the pipetting needle located at the cleaning position to perform a liquid suction action to suck the cleaning liquid held by the cleaning device;

[0162] After the liquid suction action is completed, control the first power mechanism to drive the pipetting needle to perform a liquid discharge action to discharge at least part of the cleaning liquid sucked by the liquid suction action.

[0163] In some embodiments, the controlling the first power mechanism to drive the pipetting needle located at the cleaning position to discharge the cleaning liquid includes:

[0164] Control the first power mechanism to suck cleaning liquid from the first cleaning liquid container and convey the cleaning liquid to the pipetting needle, so as to discharge the cleaning liquid through the pipetting needle.

[0165] In some embodiments, during the process of the pipetting needle moving from the sample adding position to the cleaning position, the moving trajectory of the pipetting needle on the horizontal plane is arc-shaped.

[0166] It should be noted that those skilled in the art can clearly understand that for the convenience and brevity of description, the specific working process of the above-described cleaning control method can refer to the corresponding working process of the foregoing sample analyzer, and will not be elaborated herein.

[0167] It should be understood that the terms used in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application. As used in the specification of this application and the appended claims, unless the context clearly indicates otherwise, the singular forms "a", "an" and "the" are intended to include the plural forms.

[0168] It should also be understood that the term "and / or" used in the specification of this application and the appended claims refers to any combination and all possible combinations of one or more of the related listed items, and includes these combinations. It should be noted that in this article, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or system including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or system. Without further limitation, an element defined by the statement "including a..." does not exclude the existence of additional identical elements in the process, method, article or system including that element.

[0169] The serial numbers of the embodiments of the present application above are only for description and do not represent the advantages or disadvantages of the embodiments. The above are only specific embodiments of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art can easily think of various equivalent modifications or substitutions within the technical scope disclosed by the present application, and these modifications or substitutions should all be covered by the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A sample analyzer, characterized in that, Comprising: A dispensing device for dispensing samples and / or reagents, and the dispensing device includes a pipetting needle, a needle moving mechanism for driving the movement of the pipetting needle, and a first power mechanism for providing power for the pipetting needle to perform a liquid suction action and / or a liquid discharge action; A reaction device provided with reaction positions for placing reaction vessels, and the reaction vessels are used to receive the samples and the reagents so that the samples and the reagents are mixed to form a reaction solution; A cleaning device provided with a cleaning position and used to receive the waste liquid generated during the cleaning of the pipetting needle; A first cleaning container connected to the first power mechanism and used to store the cleaning liquid; A detection device for detecting the reaction solution to obtain detection data; A controller communicatively connected to at least the dispensing device and used for: Controlling the first power mechanism to drive the pipetting needle to perform the dispensing operation of the sample and / or the reagent to the reaction vessel located at the sample addition position, and during the dispensing operation, the first power mechanism transports the cleaning liquid into the needle tube of the pipetting needle; After the dispensing operation is completed, controlling the needle moving mechanism to drive the pipetting needle to move from the sample addition position to the cleaning position, and at least controlling the first power mechanism to drive the pipetting needle located at the cleaning position to discharge the cleaning liquid to clean the inner wall of the pipetting needle; Wherein, during the process of the pipetting needle moving from the sample addition position to the cleaning position, the needle moving mechanism drives the pipetting needle to perform at least two variable speed movements of accelerating first and then decelerating in the horizontal direction.

2. The sample analyzer according to claim 1, characterized in that During the process of the pipetting needle moving from the sample addition position to the cleaning position, the controller is further used for: Controlling the needle moving mechanism to drive the pipetting needle to stay at least once in the horizontal direction.

3. The sample analyzer according to claim 1, characterized in that, During the process of the controller controlling the needle moving mechanism to drive the pipetting needle to move from the sample addition position to the cleaning position, the following is executed: Controlling the needle moving mechanism to drive the pipetting needle to move in the horizontal plane from the sample addition position along a first direction through the cleaning position to a first stop position and stay at the first stop position; After the residence time of the pipetting needle reaches a first preset duration, controlling the needle moving mechanism to drive the pipetting needle to move in the horizontal plane from the first stop position along a second direction opposite to the first direction to the cleaning position.

4. The sample analyzer according to claim 1, the sample analyzer further includes a second power mechanism, the second power mechanism is connected to the first cleaning container and used to transport the cleaning liquid in the first cleaning container to clean the outer wall of the pipetting needle located at the cleaning position; Alternatively, the sample analyzer further includes a second power mechanism and a second cleaning container, the second cleaning container is used to store the cleaning liquid, the second power mechanism is connected to the second cleaning container and used to transport the cleaning liquid in the second cleaning container to clean the outer wall of the pipetting needle located at the cleaning position.

5. The sample analyzer according to claim 4, wherein, The controller is further used for: Controlling the needle moving mechanism to drive the pipetting needle to move in the horizontal plane along the first direction from the sample addition position through the cleaning position to a first transfer position; After the pipetting needle moves to the first transfer position, control the needle moving mechanism to drive the pipetting needle to stay at the first transfer position, and control the first power mechanism to deliver cleaning liquid to the first transfer position and / or control the second power mechanism to deliver cleaning liquid to the first transfer position, so as to perform a first cleaning operation on the pipetting needle; After the first cleaning operation is completed, control the needle moving mechanism to drive the pipetting needle to move from the first transfer position to the cleaning position in a second direction opposite to the first direction on a horizontal plane; After the pipetting needle moves to the cleaning position, control the needle moving mechanism to drive the pipetting needle to stay at the cleaning position, and at least control the first power mechanism to deliver cleaning liquid to the cleaning position, so as to perform a second cleaning operation on the pipetting needle.

6. The sample analyzer according to claim 4, wherein During the process of the controller controlling the needle moving mechanism to drive the pipetting needle to move from the sample adding position to the cleaning position, the following is executed: Control the needle moving mechanism to drive the pipetting needle to perform at least one variable speed motion of accelerating first and then decelerating along a preset direction on a horizontal plane from the sample adding position until the pipetting needle moves to the second transfer position; After the pipetting needle reaches the second transfer position, control the needle moving mechanism to drive the pipetting needle to continue to perform at least one variable speed motion of accelerating first and then decelerating along the preset direction from the second transfer position until the pipetting needle moves to the cleaning position.

7. The sample analyzer according to claim 6, wherein, The controller is further configured to: After the pipetting needle moves to the second transfer position, control the needle moving mechanism to drive the pipetting needle to stay at the second transfer position; After the residence time of the pipetting needle reaches a second preset duration, control the needle moving mechanism to drive the pipetting needle to move from the second transfer position to the cleaning position in the same direction.

8. The sample analyzer according to claim 7, characterized in that, The controller is further configured to: After the pipetting needle stays at the second transfer position, control the first power mechanism to deliver cleaning liquid to the second transfer position and / or control the second power mechanism to deliver cleaning liquid to the second transfer position, so as to perform a third cleaning operation on the pipetting needle; After the third cleaning operation is completed, control the needle moving mechanism to drive the pipetting needle to move from the second transfer position to the cleaning position in the first direction on a horizontal plane; After the pipetting needle moves to the cleaning position, at least control the first power mechanism to deliver cleaning liquid to the cleaning position, so as to perform a fourth cleaning operation on the pipetting needle.

9. The sample analyzer according to any one of claims 1-8, characterized in that, The cleaning device holds cleaning liquid. During the process of the controller controlling the first power mechanism to drive the pipetting needle located at the cleaning position to discharge the cleaning liquid, the following is executed: Control the first power mechanism to drive the pipetting needle located at the cleaning position to perform a liquid suction action to suck the cleaning liquid held by the cleaning device; After the liquid suction action is completed, control the first power mechanism to drive the pipetting needle to perform a liquid discharge action to discharge at least part of the cleaning liquid sucked by the liquid suction action.

10. The sample analyzer according to any one of claims 1-8, characterized in that, During the process of the controller controlling the first power mechanism to drive the pipetting needle located at the cleaning position to discharge the cleaning liquid, the following is executed: The first power mechanism is controlled to absorb cleaning liquid into the first cleaning liquid container and transport the cleaning liquid to the pipetting needle so as to discharge the cleaning liquid through the pipetting needle.

11. The sample analyzer according to any one of claims 1-8, characterized in that, When the pipetting needle moves from the sample adding position to the cleaning position, the moving track of the pipetting needle on the horizontal plane is arc-shaped.

12. A cleaning control method, applied to a sample analyzer, the cleaning control method comprising: Controlling the first power mechanism of the sample analyzer to drive the pipette needle of the sample analyzer to perform a sample and / or reagent dispensing operation on a reaction container located at a sample adding position, wherein the first power mechanism delivers a cleaning solution into the needle tube of the pipette needle during the dispensing operation; After the dispensing operation is completed, the needle moving mechanism of the dispensing device is controlled to drive the pipetting needle of the dispensing device to move from the sample loading position to the cleaning position, and the first power mechanism of the sample analyzer is controlled to drive the pipetting needle located at the cleaning position to discharge the cleaning liquid to clean the inner wall of the pipetting needle; Wherein, during the process of the pipetting needle moving from the sample loading position to the cleaning position, the needle moving mechanism drives the pipetting needle to perform at least two speed-changing movements in the horizontal direction, namely, accelerating first and then decelerating.

13. A sample analyzer, characterized in that, include: A dispensing device, used for dispensing samples and / or reagents, and comprising a pipette needle, a needle moving mechanism for driving the pipette needle to move, and a first power mechanism for providing power for the pipette needle to perform aspiration and / or discharge actions; A reaction device, provided with a reaction position for placing a reaction container, wherein the reaction container is used to receive the sample and the reagent so that the sample and the reagent are mixed to form a reaction solution; a cleaning device, provided with a cleaning position, and used to receive waste liquid generated during the cleaning of the pipette needle; A cleaning container for storing cleaning fluid; A second power mechanism is connected to the cleaning container and is used to transport the cleaning liquid in the cleaning container to the cleaning position; A detection device, used to detect the reaction liquid and obtain detection data; A controller is at least in communication with the dispensing device and is used to: Controlling the dispensing device to perform the dispensing operation of the sample and / or the reagent into the reaction container located at the sample loading position; After the dispensing operation is completed, controlling the needle moving mechanism to drive the pipetting needle to move from the sample loading position to the cleaning position; After the pipetting needle reaches the cleaning position, the needle moving mechanism is controlled to drive the pipetting needle to stay at the cleaning position, and the second power mechanism is controlled to absorb cleaning liquid from the cleaning container and transport the cleaning liquid to the cleaning position, so as to clean the outer wall of the pipetting needle located at the cleaning position; Wherein, during the process of the pipetting needle moving from the sample loading position to the cleaning position, the needle moving mechanism at least drives the pipetting needle to perform two speed-changing movements in the horizontal direction, namely, accelerating first and then decelerating.

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