Zinc-based antibacterial agent as well as preparation method and application thereof

Abstract

The invention discloses a zinc-based antibacterial agent as well as a preparation method and application thereof, and relates to the technical field of antibacterial agents. According to the zinc-based antibacterial agent, (Z)-octadecane-9-enol is used as a surfactant, zinc fumarate is used as a matrix raw material, an alcohol-water system is adopted for preparing the zinc-based antibacterial agent, and the product has good antibacterial property. No basic group is added in the preparation process, the problems of aggregation and poor dispersity of Zn particles are greatly solved, and the prepared antibacterial material is uniform in size distribution and small in particle size; the zinc-based antibacterial material prepared by the method has the advantages of high yield, high purity, simple process preparation means and no pollution to the environment, and can realize large-scale industrial production; the zinc-based antibacterial material obtained by the method can be applied to polyester, endows the polyester with excellent antibacterial performance, and does not generate rejection reaction with a polyester matrix.

Description

Technical Field

[0001] This application relates to the technical field of antibacterial agents, and particularly relates to a zinc-based antibacterial agent, a preparation method thereof, and an application thereof. Background Art

[0002] While bacteria, as decomposers, accelerate the material cycle in nature, they also bring troubles and even harms to people's lives. How to prepare materials with good antibacterial effects and no drug resistance to bacteria during long-term use has become an important research direction. Due to the safety, long-acting property, heat resistance, and excellent antibacterial properties of Zn particles, they have been widely used in the fields of food and drug packaging. The antibacterial mechanism of zinc-based antibacterial agents is similar to that of ordinary silver-based antibacterial materials, and the process is to directly contact with proteins to destroy cells. For Zn particles, Zn 2+ ion leaching destroys cell permeability and generates reactive oxygen species (ROS) to decompose nutrients. Zinc-based antibacterial materials are a broad-spectrum antibacterial substance and have an inhibitory effect on the growth of various bacteria. As antibacterial packaging materials, especially food packaging antibacterial materials, the selected antibacterial agents must be harmless to the human body. Zn particles are not only harmless to the human body, but also have good thermal stability, persistence, and bacteria have no drug resistance to them, and can be used as a new generation of inorganic antibacterial agents. Summary of the Invention

[0003] This application provides a zinc-based antibacterial agent, a preparation method thereof, and an application thereof to solve technical problems such as unstable size and poor antibacterial performance of existing zinc-based antibacterial agents.

[0004] In the first aspect, this application provides a zinc-based antibacterial agent, and the raw materials of the zinc-based antibacterial agent include: a surfactant and zinc fumarate.

[0005] Optionally, the surfactant is (Z)-octadec-9-enol.

[0006] Optionally, the molar ratio of the surfactant to zinc fumarate is 0.5-2:1.

[0007] In the second aspect, this application provides a preparation method of a zinc-based antibacterial agent, including the following steps:

[0008] Prepare a zinc fumarate solution and a surfactant solution respectively;

[0009] Heat the surfactant solution to a set temperature and add the zinc fumarate solution;

[0010] After reacting for a set time at the set temperature, separate and process the reaction product to obtain a zinc-based antibacterial agent.

[0011] Optionally, the molar ratio of zinc fumarate to the solution is 1:10.

[0012] Optionally, the solvent of the surfactant solution is ethanol.

[0013] Optionally, the mass concentration of the surfactant solution is 20% wt.

[0014] Optionally, the set temperature is 60°C to 80°C.

[0015] Optionally, the set time is 30 min to 60 min.

[0016] Optionally, separating the reaction product specifically includes: allowing the reaction product to stand for precipitation, washing the precipitate and then separating the product, and drying at room temperature.

[0017] In a third aspect, the present invention also provides the application of the zinc-based antibacterial agent in antibacterial drugs and antibacterial materials.

[0018] The above technical solution provided by the present invention has the following advantages compared with the prior art:

[0019] The present invention provides a zinc-based antibacterial agent, a preparation method and an application thereof. The present invention uses (Z)-octadec-9-enol as a surfactant and zinc fumarate as a matrix raw material, and prepares a zinc-based antibacterial agent by an alcohol-water system. The product has good antibacterial properties. During the preparation process, no base is added, which greatly solves the problems of Zn particle agglomeration and poor dispersion. The prepared antibacterial material has a uniform size distribution and small particle size; the zinc-based antibacterial material prepared by this method has a large yield, high purity, simple preparation means and no pollution to the environment, and can realize large-scale industrial production; the zinc-based antibacterial material obtained by this method can be applied to polyester, endows it with excellent antibacterial properties and does not produce a rejection reaction with the polyester matrix. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The drawings herein are incorporated into the specification and form a part of the specification, showing embodiments consistent with the present application, and are used together with the specification to explain the principles of the present application.

[0021] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, for those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0022] Figure 1 It is the XRD pattern of the zinc-based antibacterial agent provided in different embodiments of the present application.

[0023] Figure 2 It is the electron micrograph of the zinc-based antibacterial agent provided in Example 1, the molar ratio of (Z)-octadec-9-enol to zinc fumarate is 0.5:1, and the temperature is 60°C.

[0024] Figure 3 It is the electron micrograph of the zinc-based antibacterial agent provided in Example 2. The molar ratio of (Z)-octadec-9-enol to zinc fumarate is 1:1, and the temperature is 60 °C.

[0025] Figure 4 It is the electron micrograph of the zinc-based antibacterial agent provided in Example 3. The molar ratio of (Z)-octadec-9-enol to zinc fumarate is 2:1, and the temperature is 80 °C.

[0026] Figure 5 It is the electron micrograph of the zinc-based antibacterial agent provided in Example 4. The molar ratio of (Z)-octadec-9-enol to zinc fumarate is 2:1, and the temperature is 70 °C.

[0027] Figure 6 It is the electron micrograph of the zinc-based antibacterial agent provided in Example 5. The molar ratio of (Z)-octadec-9-enol to zinc fumarate is 2:1, and the temperature is 60 °C.

[0028] Figure 7 It is the antibacterial plate diagram of zinc-rich solutions with different concentrations against Staphylococcus aureus: There is no zinc-rich solution in Figure a, the zinc-rich solution is 2×10 -3 mol / L in Figure b, the zinc-rich solution is 4×10 -3 mol / L in Figure c, and the zinc-rich solution is 6×10 -3 mol / L in Figure d.

[0029] Figure 8 It is the antibacterial plate diagram of zinc-rich solutions with different concentrations against Escherichia coli: There is no zinc-rich solution in Figure a, the zinc-rich solution is 2×10 -3 mol / L in Figure b, the zinc-rich solution is 4×10 -3 mol / L in Figure c, and the zinc-rich solution is 6×10 -3 mol / L in Figure d. Detailed implementation manners

[0030] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions in the embodiments of this application will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of this application. Obviously, the described embodiments are part of the embodiments of this application, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in this application without creative efforts fall within the scope of protection of this application.

[0031] Various embodiments of the present application may exist in the form of a range; it should be understood that the description in the form of a range is only for convenience and brevity, and should not be construed as a rigid limitation on the scope of the present application; therefore, it should be considered that the described range description has specifically disclosed all possible sub-ranges and individual values within the range. For example, it should be considered that the range description from 1 to 6 has specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., and individual numbers within the range, such as 1, 2, 3, 4, 5, and 6, which applies regardless of the range. Additionally, whenever a numerical range is indicated herein, it means including any cited number (fraction or integer) within the indicated range.

[0032] In the present application, unless otherwise stated, terms including "comprising" etc. mean "including but not limited to". In this text, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. In this text, "and / or" describes the associated relationship of associated objects and indicates that three relationships can exist. For example, A and / or B can mean: A exists alone, A and B exist simultaneously, and B exists alone. Where A and B can be singular or plural. In this text, "at least one" means one or more, and "a plurality" means two or more. "At least one kind", "at least one (item) of the following" or similar expressions refer to any combination of these items, including any combination of single item (item) or plural items (items). For example, "at least one (item) of a, b, or c", or, "at least one (item) of a, b, and c" can both mean: a, b, c, a - b (i.e., a and b), a - c, b - c, or a - b - c, where a, b, and c can be single or multiple respectively.

[0033] Unless otherwise specifically stated, various raw materials, reagents, instruments, equipment, etc. used in the present application can be obtained through market purchase or can be prepared by existing methods.

[0034] In a first aspect, the present application provides a zinc - based antibacterial agent, and the raw materials of the zinc - based antibacterial agent include: a surfactant and zinc fumarate.

[0035] In an optional embodiment, the surfactant is (Z) - octadec - 9 - enol.

[0036] In an optional embodiment, the molar ratio of the surfactant to zinc fumarate is 0.5 - 2:1. For example, the molar ratio can be selected as 0.5:1, 1:1, 1.5:1, 2:1.

[0037] Second aspect, based on the same inventive concept, the present invention also provides a preparation method of the zinc-based antibacterial agent described in the first aspect, comprising the following steps:

[0038] Prepare a zinc fumarate solution and a surfactant solution respectively;

[0039] Heat the surfactant solution to a set temperature and add the zinc fumarate solution;

[0040] After reacting for a set time at the set temperature, separate and process the reaction product to obtain the zinc-based antibacterial agent.

[0041] In an optional embodiment, the molar ratio of zinc fumarate to the solution is 1:10.

[0042] In an optional embodiment, the mass concentration of the surfactant solution is 20% wt.

[0043] In an optional embodiment, the surfactant is (Z)-octadec-9-en-1-ol.

[0044] In an optional embodiment, the solvent of the surfactant solution is selected as ethanol.

[0045] In the above embodiment, using ethanol as the solvent of the surfactant helps to dissolve the surfactant while reducing the cost.

[0046] In an optional embodiment, the set temperature is 60°C to 80°C, and the heating temperature can be selected as 60°C, 65°C, 70°C, 75°C or 80°C.

[0047] In the above embodiment, the reaction is carried out in a thermostatic water bath, and other equipment with controllable temperature can also be selected as the reactor. Setting the reaction temperature can, on the one hand, accelerate the reaction, and on the other hand, increase the solubility of the surfactant.

[0048] In an optional embodiment, when adding the zinc fumarate solution, the zinc fumarate solution is added to the reaction system of the surfactant solution in a slow addition manner.

[0049] In an optional embodiment, the set time is 30 min to 60 min, for example, the reaction time can be 30 min, 35 min, 40 min, 45 min, 50 min, 55 min or 60 min.

[0050] In the above embodiment, the length of the reaction time is related to the amount, concentration of the reactants and the reaction temperature. Therefore, the reaction time varies. Usually, the end of the reaction can be marked by the fact that the precipitate product no longer increases, and generally the reaction time is between 30 min and 60 min.

[0051] In an alternative embodiment, the separation of the reaction product specifically includes: allowing the reaction product to stand for precipitation, washing the precipitate and then separating the product, and drying at room temperature.

[0052] In an alternative embodiment, a suspension containing a zinc-based antibacterial agent is poured into a beaker and allowed to stand for precipitation. After repeatedly washing the precipitate with ethanol and water respectively, the product is centrifuged and dried at room temperature to obtain a zinc-based antibacterial agent powder sample.

[0053] In the above embodiment, water and ethanol can effectively remove the impurities attached to the surface of the precipitate, including the surfactant and zinc fumarate that have not reacted completely.

[0054] In a third aspect, based on the same inventive concept, the present invention also provides the application of the zinc-based antibacterial agent described in the first aspect in antibacterial drugs and antibacterial materials.

[0055] As an alternative embodiment, the zinc-based antibacterial agent can be used to make antibacterial drugs.

[0056] As an alternative embodiment, the zinc-based antibacterial agent can be used to prepare antibacterial materials.

[0057] In the above embodiment, since no base is added in the preparation method of the present invention to prepare the zinc-based antibacterial material, the problems of Zn particle agglomeration and poor dispersibility are greatly solved. The prepared antibacterial material has a uniform size distribution and small particle size; the zinc-based antibacterial material prepared by this method has a large yield, high purity, simple preparation process and no pollution to the environment, and can realize large-scale industrial production.

[0058] In addition, applying the zinc-based antibacterial material obtained in this method to polyester materials can not only endow the polyester materials with antibacterial properties, but also the raw material will not cause a rejection reaction with the polyester matrix, ensuring the performance of the polyester materials.

[0059] The following further elaborates the present application with specific examples. It should be understood that these examples are only used to illustrate the present application and not to limit the scope of the present application. The experimental methods without specific conditions noted in the following examples are usually determined according to industry standards. If there is no corresponding industry standard, they are carried out according to general international standards, conventional conditions, or the conditions recommended by the manufacturer.

[0060] Example 1

[0061] This example provides a zinc-based antibacterial agent, the raw materials of which include (Z)-octadec-9-enol and zinc fumarate, and their molar ratio is 2:1. The preparation method includes the following steps:

[0062] Prepare zinc fumarate solution: Weigh a certain amount of zinc fumarate and add 10 ml of distilled water to dissolve it to obtain a zinc fumarate solution with a molar concentration of 20%;

[0063] Prepare surfactant solution: Mix a certain amount of surfactant (Z)-octadec-9-enol with 490 ml of ethanol solvent to obtain a surfactant ethanol solution with a mass concentration of 20%;

[0064] Add the surfactant ethanol solution to the microchannel reactor and heat it to the set temperature of 80 °C. After (Z)-octadec-9-enol is dissolved, slowly add the prepared precursor zinc fumarate aqueous solution to the reaction system and react at this temperature for 30 min.

[0065] After the reaction is completed, pour the suspension containing the zinc-based antibacterial agent into a beaker and let it stand for precipitation. After repeatedly washing the precipitate with ethanol and water, centrifuge the product and dry it at room temperature to obtain a zinc-based antibacterial agent powder sample.

[0066] Example 2

[0067] This example provides a zinc-based antibacterial agent, the raw materials of which include (Z)-octadec-9-enol and zinc fumarate, and their molar ratio is 2:1. Its preparation method includes the following steps:

[0068] Prepare zinc fumarate solution: Weigh a certain amount of zinc fumarate and add 10 ml of distilled water to dissolve it to obtain a zinc fumarate solution with a molar concentration of 20%;

[0069] Prepare surfactant solution: Mix a certain amount of surfactant (Z)-octadec-9-enol with 490 ml of ethanol solvent to obtain a surfactant ethanol solution with a mass concentration of 20%;

[0070] Add the surfactant ethanol solution to the microchannel reactor and heat it to the set temperature of 60 °C. After (Z)-octadec-9-enol is dissolved, slowly add the prepared precursor zinc fumarate aqueous solution to the reaction system and react at this temperature for 60 min.

[0071] After the reaction is completed, pour the suspension containing the zinc-based antibacterial agent into a beaker and let it stand for precipitation. After repeatedly washing the precipitate with ethanol and water, centrifuge the product and dry it at room temperature to obtain a zinc-based antibacterial agent powder sample.

[0072] Example 3

[0073] This example provides a zinc-based antibacterial agent, the raw materials of which include (Z)-octadec-9-enol and zinc fumarate, and their molar ratio is 2:1. Its preparation method includes the following steps:

[0074] Prepare zinc fumarate solution: Weigh a certain amount of zinc fumarate and add 10 ml of distilled water to dissolve it to obtain a zinc fumarate solution with a molar concentration of 20%;

[0075] Prepare surfactant solution: Mix a certain amount of surfactant (Z)-octadec-9-enol with 490 ml of ethanol solvent to obtain a surfactant ethanol solution with a mass concentration of 20%;

[0076] Add the surfactant ethanol solution to the microchannel reactor and heat it to the set temperature of 70 °C. After (Z)-octadec-9-enol is dissolved, slowly add the prepared aqueous solution of zinc fumarate precursor to the reaction system and react at this temperature for 40 min.

[0077] After the reaction is completed, pour the suspension containing the zinc-based antibacterial agent into a beaker and let it stand for precipitation. Wash the precipitate repeatedly with ethanol and water, then centrifuge the product and dry it at room temperature to obtain a zinc-based antibacterial agent powder sample.

[0078] Example 4

[0079] This example provides a zinc-based antibacterial agent, the raw materials of which include (Z)-octadec-9-enol and zinc fumarate, and their molar ratio is 1:1. The preparation method includes the following steps:

[0080] Prepare zinc fumarate solution: Weigh a certain amount of zinc fumarate and add 10 ml of distilled water to dissolve it to obtain a zinc fumarate solution with a molar concentration of 20%;

[0081] Prepare surfactant solution: Mix a certain amount of surfactant (Z)-octadec-9-enol with 490 ml of ethanol solvent to obtain a surfactant ethanol solution with a mass concentration of 20%;

[0082] Add the surfactant ethanol solution to the microchannel reactor and heat it to the set temperature of 70 °C. After (Z)-octadec-9-enol is dissolved, slowly add the prepared aqueous solution of zinc fumarate precursor to the reaction system and react at this temperature for 40 min.

[0083] After the reaction is completed, pour the suspension containing the zinc-based antibacterial agent into a beaker and let it stand for precipitation. Wash the precipitate repeatedly with ethanol and water, then centrifuge the product and dry it at room temperature to obtain a zinc-based antibacterial agent powder sample.

[0084] Example 5

[0085] This example provides a zinc-based antibacterial agent, the raw materials of which include (Z)-octadec-9-enol and zinc fumarate, and their molar ratio is 0.5:1. The preparation method includes the following steps:

[0086] Prepare zinc fumarate solution: Weigh a certain amount of zinc fumarate and add 10 ml of distilled water to dissolve it to obtain a zinc fumarate solution with a molar concentration of 20%;

[0087] Prepare surfactant solution: Mix a certain amount of surfactant (Z)-octadec-9-enol with 490 ml of ethanol solvent to obtain a surfactant ethanol solution with a mass concentration of 20%;

[0088] Add the surfactant ethanol solution to the microchannel reactor and heat it to the set temperature of 70 °C. After (Z)-octadec-9-enol is dissolved, slowly add the prepared precursor zinc fumarate aqueous solution to the reaction system and react at this temperature for 40 min.

[0089] After the reaction, pour the suspension containing the zinc-based antibacterial agent into a beaker and let it stand for precipitation. Wash the precipitate repeatedly with ethanol and water, then centrifuge the product and dry it at room temperature to obtain a zinc-based antibacterial agent powder sample.

[0090] In order to test the structure and antibacterial properties of the zinc-based antibacterial agents provided in Examples 1 to 3, the following experiments were conducted for testing:

[0091] Experimental Example 1

[0092] In this experimental example, X-ray diffraction was performed on the zinc-based antibacterial agents provided in Examples 1 to 5 respectively. The XRD curves of the antibacterial agents prepared with different parameters were plotted on one XRD pattern, as Figure 1 shown. It can be seen from the figure that all the curves have corresponding peaks, only with different intensities. It can be seen that zinc-based antibacterial agents were successfully prepared in each example.

[0093] Experimental Example 2

[0094] In this experimental example, scanning electron microscopy was performed on the zinc-based antibacterial agents provided in Examples 1 to 5 respectively to determine their morphological characteristics, as Figures 2 - 6 shown. It can be seen from the figure that all the zinc-based antibacterial agent products are spherical, only with different particle sizes. The particle sizes in each figure are uniform and the distribution range is narrow.

[0095] Experimental Example 3

[0096] Weigh appropriate amounts of Zn-based antibacterial agent powder, ultrasonicate it for 30 min at room temperature to prepare a zinc-rich solution with a certain concentration. Weigh 33 g of nutrient agar and pour it into a 1000 ml beaker, add 1000 ml of distilled water and heat and stir. When it is completely dissolved and the solution is transparent, stop stirring and heating. Adjust the pH with a 100 g / L NaOH solution until the pH value of the solution is 7.2 - 7.4. Subsequently, in a sterile environment, dilute the activated bacterial solution to 10- 4 Reserve it at a concentration of mol / L. Add 7.33 ml, 5.67 ml, and 4 ml of sterilized distilled water to 3 sterilized test tubes respectively, and add 1 ml of zinc-rich solution and 1 ml of bacterial solution to each of them. After shaking well, a solution with an antibacterial concentration of 2×10 -3 mol / L is obtained. Transfer 1 ml of the prepared antibacterial solution to a sterilized petri dish (3 parallel samples are made for each sample), pour in the culture medium, gently shake the petri dish to mix it evenly, and let the petri dish stand still to cool. When the culture medium solidifies, invert the petri dish and culture it in a constant temperature incubator at 37°C for 36 h and observe the colony growth situation.

[0097] The above-mentioned bacterial solutions respectively use Staphylococcus aureus and Escherichia coli, and the experimental results are as Figure 7 and 8 shown. Figure 7 The following is the antibacterial plate diagram of different concentrations of zinc-rich solutions against Staphylococcus aureus. It can be seen from the figure that Figure 7 (a) does not add zinc-rich solution, that is, no zinc-based antibacterial agent is added, and the number of Staphylococcus aureus is very large; Figure 7 (b)-(d) The concentration of zinc-rich solution gradually increases, that is, the content of zinc-based antibacterial agent increases. Compared with Figure 7 (a), it can be seen that the number of Staphylococcus aureus in the petri dish is significantly reduced, and with the increase of the antibacterial agent, the amount of Staphylococcus aureus becomes less and less. When the concentration of the zinc-rich solution is 6×10 -3 mol / L, as Figure 7 (d) shows, the number of Staphylococcus aureus is almost zero.

[0098] Figure 8 The following is the antibacterial plate diagram of different concentrations of zinc-rich solutions against Escherichia coli. It can be seen from the figure that Figure 8 (a) does not add zinc-rich solution, that is, no zinc-based antibacterial agent is added, and the number of Escherichia coli is very large; Figure 8 (b)-(d) The concentration of zinc-rich solution gradually increases, that is, the content of zinc-based antibacterial agent increases. Compared with Figure 8 (a), it can be seen that the number of Escherichia coli in the petri dish is significantly reduced, and with the increase of the antibacterial agent, the amount of Escherichia coli becomes less and less.

[0099] It can be seen that the zinc-based antibacterial agent provided in this application has certain antibacterial properties against both Staphylococcus aureus and Escherichia coli, and it can be applied in antibacterial drugs or antibacterial materials.

[0100] In summary, the performance test results of the zinc-based antibacterial agent provided in each embodiment of this application are summarized in Table 1 as follows:

[0101] Table 1 Performance test results of the zinc-based antibacterial agents provided in Examples 1 to 5

[0102] Zinc-based antibacterial agent (nano-ZnO) Example 1 Example 2 Example 3 Example 4 Example 5 Average particle size of nanoparticles (nm) 9.80 10.62 8.74 6.35 5.18 Morphology Spherical Spherical Spherical Spherical Spherical Average yield 76.1％ 83.4％ 91.2％ 93.4％ 94.6％ Purity ≥99.0 ≥99.0 ≥99.0 ≥99.0 ≥99.0 <![CDATA[Specific surface area m 2 / g]]> 112 103 120 125 131 Average antibacterial rate against Staphylococcus aureus 82.2％ 79.9％ 92.9％ 94.8％ 97.2％ Average antibacterial rate against Escherichia coli 81.3％ 74.5％ 84.3％ 88.2％ 92.5％ Average antibacterial activity of PET / n-ZnO composite against Staphylococcus aureus 80.6％ 79.2％ 89.6％ 95.6％ 98.6％ Average antibacterial rate of PET / n-ZnO composite against Escherichia coli 75.2％ 70.3％ 80.2％ 82.5％ 86.7％

[0103] As can be seen from the results in Table 1, the structures of the zinc-based antibacterial agents provided in each example are spherical, with stable sizes, certain antibacterial properties, and high yields, and they can be applied to the preparation of antibacterial drugs and antibacterial materials.

[0104] The above are only specific embodiments of the present application, enabling those skilled in the art to understand or implement the present application. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to these embodiments shown herein, but rather will conform to the widest scope consistent with the principles and novel features claimed herein.

Claims

1. A zinc-based antibacterial agent, characterized in that, The raw materials of the zinc-based antibacterial agent include: a surfactant and zinc fumarate.

2. The zinc-based antibacterial agent according to claim 1, wherein The surfactant is (Z)-octadec-9-en-1-ol.

3. The zinc-based antibacterial agent according to claim 1, characterized in that, The molar ratio of the surfactant to zinc fumarate is 0.5-2:

1.

4. A preparation method of the zinc-based antibacterial agent according to any one of claims 1 to 3, characterized in that, It includes the following steps: Prepare a zinc fumarate solution and a surfactant solution respectively; Heat the surfactant solution to a set temperature and add the zinc fumarate solution; After reacting for a set time at the set temperature, separate and process the reaction product to obtain the zinc-based antibacterial agent.

5. According to the preparation method described in claim 4, the molar concentration of the zinc fumarate solution is 20%.

6. The preparation method according to claim 4, wherein The mass concentration of the surfactant solution is 20% wt.

7. The preparation method according to claim 4, characterized in that, The set temperature is 60°C - 80°C.

8. The preparation method according to claim 4, characterized in that, The set time is 30 min - 60 min.

9. The preparation method according to claim 4, wherein The separation and treatment of the reaction product specifically include: allowing the reaction product to stand and precipitate, washing the precipitate and then separating the product, and drying at room temperature.

10. Use of the zinc-based antibacterial agent according to any one of claims 1 to 3 in antibacterial drugs and antibacterial materials.

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