Preparation method, delivery system and application of skin care composition

Abstract

The invention relates to a preparation method of a skin care composition and a delivery system and application of the skin care composition. The method comprises the following steps: preparing a nano-emulsion carrier containing phospholipid-amine bond-polyethylene glycol, chitosan and the like; mixing the phytoestrogen powder, the humectant, the whitening component and the like to obtain an active component mixture; and integrating the two components, and adding a penetration enhancer to form the skin care product composition. The composition shows excellent active ingredient transmittance in an in-vitro transdermal absorption test, and is good in stability; the water content of the skin is stably kept above 60% after 4 hours; the skin brightness change advantage in a whitening test is obvious; in an anti-aging performance test, the reduction rate of facial wrinkles can reach about 40% after the facial mask is used for 3 months, and the facial mask is good in use experience, free of uncomfortable reaction and wide in market application prospect.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and particularly relates to a preparation method of a skin care composition, its delivery system and application, aiming to enhance the moisturizing, whitening and anti-wrinkle effects, and at the same time solve the problems of the stability of active ingredients and skin permeability. Background Art

[0002] With the increasing emphasis on skin care by people, the quality requirements for cosmetics and skin care products are also constantly improving. At present, the quality of anti-aging cosmetics on the market is uneven. In most anti-aging cosmetics, the active ingredients are usually polyphenols, vitamins or polypeptide compounds. These active ingredients are relatively sensitive to environmental factors such as light, heat and pH value. When directly added to the product formula, the active ingredients are easily degraded and inactivated due to environmental influences. In addition, the stratum corneum of the skin has a strong barrier function, and many active molecules, such as active peptides, are difficult to penetrate in the stratum corneum and cannot effectively reach the target site, thus greatly weakening the skin care effect and making the anti-aging effect not obvious. Moreover, since skin aging is a complex physiological process involving multiple mechanisms, active substances with different action mechanisms need to cooperate with each other to fully achieve the anti-aging effect. However, most of the current anti-aging skin care products on the market only start from antioxidant to deal with skin aging problems, lacking a diversified anti-aging strategy, and ultimately resulting in unsatisfactory anti-aging effects.

[0003] As a natural active ingredient, phytoestrogens have attracted much attention due to their various skin-beneficial effects such as whitening, moisturizing and anti-aging. For example, estrogen mimics (such as soy isoflavones, red clover extract) can activate skin estrogen receptors, promote collagen synthesis, improve barrier function and inhibit melanin production. However, in practical applications, phytoestrogens have some problems that need to be solved urgently: on the one hand, the stability of their active ingredients is poor and they are easily inactivated by environmental factors; on the other hand, the penetration efficiency of phytoestrogens in the skin barrier is low and it is difficult to penetrate deep into the skin to play a role. These factors have greatly limited the wide application of phytoestrogens in cosmetics and skin care products.

[0004] The prior art has proposed various solutions to the above problems: (1) Carrier encapsulation technology: Microencapsulation (such as cyclodextrin inclusion), liposomes or nanoemulsion systems are used to reduce the degradation of phytoestrogens by environmental factors through physical isolation. For example, the encapsulation efficiency of soy isoflavones is increased to 85% using a lecithin-cholesterol composite carrier, and the stability during storage at room temperature is extended to 12 months. However, the particle sizes of such carriers are mostly in the range of 100 - 500 nm. Although they can improve the retention in the epidermis, it is difficult to achieve dermal delivery, and high concentrations of surfactants may cause skin irritation. (2) Chemical modification strategies: The molecular stability is enhanced through glycosylation, esterification or polymer grafting (such as polyethylene glycolylation), but skin allergies or discomfort symptoms may be caused after chemical modification. (3) Transdermal penetration enhancement technology: Co-use of penetration enhancers such as alcohols (such as ethanol), fatty acids or physical penetration enhancement (microneedles, iontophoresis) is used to promote the penetration of phytoestrogen active ingredients into the deep layer of the skin. As reported in relevant literature, the transdermal amount of puerarin is significantly increased through an ethanol-menthol co-solvent system, but long-term use is likely to damage the skin barrier and cause sensitivity reactions.

[0005] Despite the certain progress made in the prior art, the following key problems still need to be urgently addressed: First, it is difficult to synergistically achieve enhanced stability and improved transdermal efficiency. Most carrier systems reduce the transdermal efficiency due to excessive particle size or inappropriate surface charge while improving stability; Second, the contradiction between the biocompatibility of the carrier material and the controllable release of the active ingredient is prominent. For example, although chitosan-based carriers have pH-responsive release characteristics, their cationic properties are likely to interact with the lipids in the stratum corneum, causing a sense of skin tightness and triggering skin discomfort reactions, etc.

[0006] Therefore, on the premise of not damaging the skin barrier function, developing a skin care composition that not only has high efficient stabilization characteristics, can deeply penetrate the skin, but also has good skin adaptability has become the key to breaking through the application of phytoestrogen skin care products. Summary of the Invention

[0007] The purpose of the present invention is to overcome the defects existing in the above prior art and provide a preparation method, delivery system and application of a skin care composition based on phytoestrogens. A system that effectively delivers phytoestrogens to the deep layer of the skin and exerts various functions through a specific method well solves the problems such as poor stability of phytoestrogen active ingredients and low penetration efficiency in the skin barrier, and significantly improves the efficacy in aspects such as whitening the skin, moisturizing the skin, improving complexion and anti-aging.

[0008] The present invention relates to a preparation method of a skin care composition, comprising the following steps:

[0009] (1)Preparation of nanoemulsion carrier: Phospholipid-hydrazone bond-polyethylene glycol, chitosan, ceramide, emulsifier and an appropriate amount of water are mixed, and then subjected to high-speed shearing and homogenization treatment to form a nanoemulsion carrier;

[0010] (2)Mixing of active ingredients: Phytoestrogen powder, humectant, and whitening ingredient are separately dispersed in water and mixed evenly to obtain a mixture of active ingredients;

[0011] (3)Integrated system: The mixture obtained in step (2) is added to the nanoemulsion carrier prepared in step (1), stirred evenly, and a penetration enhancer is added, and stirring is continued until completely dispersed to form a uniform skin care composition.

[0012] Preferably, the high-speed shearing is carried out at 7000-10000 r / min for 1-15 min; the homogenization treatment is carried out at 10-100 Mpa for 1-10 times.

[0013] Preferably, the phytoestrogen powder includes any one of soy isoflavones, resveratrol, and puerarin, and further preferably is a compound of soy isoflavones, resveratrol, and puerarin in a mass ratio of 5-15:3-10:2-8.

[0014] Preferably, the number-average molecular weight of the chitosan is 1000-5000 Da, and the degree of deacetylation > 90%.

[0015] Preferably, the emulsifier is at least one of polyoxyethylene castor oil emulsifiers, polyoxyethylene hydrogenated castor oil emulsifiers, polyglycerol emulsifiers, and glucoside emulsifiers.

[0016] Preferably, the humectant includes at least one of hyaluronic acid, glycerol, and butanediol.

[0017] Preferably, the whitening ingredient includes at least one of niacinamide, sialic acid, vitamin C, carnosine, and ellagic acid.

[0018] Preferably, the penetration enhancer is a natural penetration enhancer, and the natural penetration enhancer is at least one of tea tree oil and lauryl alcohol derivatives. The lauryl alcohol derivatives are at least one of laurocapram, menthyl laurate, and polyethylene glycol laurate.

[0019] Preferably, the skin care composition further contains one or more additives selected from the group consisting of emollients, thickeners, plant extracts, pH regulators, fragrances, and combinations thereof.

[0020] Preferably, the emollient is at least one of squalane, jojoba oil, caprylic / capric triglyceride, polydimethylsiloxane, polydimethylsiloxanol, and hydrogenated polyisobutene.

[0021] Preferably, the thickening agent is at least one of xanthan gum, carbomer, sodium polyacrylate, and sodium carboxymethyl cellulose.

[0022] Preferably, the plant extract is at least one of licorice extract, aloe extract, dendrobium officinale extract, and centella asiatica extract.

[0023] Preferably, the pH regulator is at least one of disodium ethylenediaminetetraacetate, triethanolamine, and sodium citrate.

[0024] Preferably, the flavoring agent is selected from at least one of vanillin, menthol, rose essential oil, jasmine essential oil, carnation essential oil, gardenia essential oil, and violet essential oil.

[0025] The nanoemulsion carrier of the present invention is a skin delivery body of ceramide and phospholipid having a structure similar to skin lipids. On the one hand, the multi-effect skin delivery system can promote or improve the skin absorption of active ingredients such as phytoestrogen powder. In addition, the multi-effect skin delivery system containing the nanoemulsion carrier can enhance skin affinity and moisturizing power by forming a lamellar structure similar to the skin cutin layer structure, thereby improving the skin barrier function.

[0026] Preferably, in step (1), the particle size of the nanoemulsion carrier is between 50 - 300 nm, preferably 100 - 300 nm, and particularly preferably 150 - 200 nm. The particle size in this range can improve the stability of active ingredients such as phytoestrogen and promote its skin penetration. When the particle size exceeds the above range, the stability of the nanoparticle delivery carrier decreases. When the particle size is lower than the above range, interparticle aggregation is likely to occur, which is not conducive to promoting the penetration of active ingredients, and the skin absorption of active ingredients such as phytohormones decreases.

[0027] Preferably, relative to the total weight of the skin care product composition, the content of phospholipid - hydrazone bond - polyethylene glycol is 0.01 - 3 wt%, and preferably, the content of phospholipid - hydrazone bond - polyethylene glycol is 0.5 - 1.5 wt%.

[0028] Preferably, relative to the total weight of the skin care product composition, the ceramide content is 0.05 - 1.5 wt%, and preferably, the ceramide content is 0.1 - 0.5 wt%.

[0029] Preferably, relative to the total weight of the skin care product composition, the content of phytoestrogen powder is 1 - 10 wt%.

[0030] Preferably, relative to the total weight of the skin care product composition, the chitosan content is 0.01 - 0.5 wt%.

[0031] Preferably, relative to the total weight of the skin care product composition, the emulsifier content is 0.5 - 5.0 wt%.

[0032] Preferably, relative to the total weight of the skin care product composition, the content of the humectant is 1-5 wt%.

[0033] Preferably, relative to the total weight of the skin care product composition, the content of the whitening ingredient is 0.5-2 wt%.

[0034] Preferably, relative to the total weight of the skin care product composition, the content of the penetration enhancer is 0.1-5 wt%.

[0035] The phospholipid-hydrazone bond-polyethylene glycol system used in the present invention combines the biocompatibility of phospholipids, the pH sensitivity of hydrazone bonds, and the stability and hydrophilicity of PEG, and can effectively improve the permeability and stability of active ingredients. This carrier system can not only protect active ingredients from degradation, but also enhance their effects in the skin through precise release and sustained release mechanisms. Phospholipids are one of the main components of cell membranes and have good biocompatibility and affinity. Phospholipids can form a stable bilayer structure, in which active ingredients can be encapsulated to form a structure similar to the cell membrane, which is beneficial to protecting active ingredients from the influence of the external environment and enhancing their stability during storage and use. The hydrazone bond is a pH-sensitive chemical bond that is stable in a neutral pH environment but undergoes hydrolysis cleavage under acidic conditions (such as the skin surface or follicular microenvironment), thereby releasing the encapsulated active ingredients and increasing the local concentration and penetration efficiency. This property enables active ingredients to be precisely released at the site where they need to exert their effects, improving their permeability and utilization rate in the skin. The hydrophilicity of PEG can reduce the interfacial tension between the skin surface and active ingredients, making it easier for active ingredients to penetrate deep into the skin.

[0036] Furthermore, the present invention combines chitosan and ceramide as carriers for phytoestrogenic active ingredients to synergistically enhance the permeability and stability of active ingredients. Ceramide is similar to the natural lipid structure of the skin, repairs the stratum corneum barrier and forms a lipid channel to promote the penetration of lipophilic components; in addition, ceramide and phospholipid-hydrazone bond-polyethylene glycol construct a lipid bilayer membrane to isolate easily oxidized active substances, synergistically antioxidant and stabilize the emulsion system, significantly enhancing the chemical stability of active ingredients. Chitosan forms a semi-permeable membrane on the skin surface, which can prolong the residence time of active ingredients, enhance ingredient penetration, and further improve skin care effects such as moisturization. Therefore, when the three are used in combination, a "phospholipid-lipid-polysaccharide composite carrier" is formed, combining the physical barrier of chitosan and the chemical protection of ceramide to achieve improved transdermal absorption efficiency and high-efficiency protection of photosensitive components, and optimizing the delivery system with technologies such as nanostructuring and biomimetic liposomes. Finally, by enhancing the penetration depth, prolonging the action time, and maintaining the activity stability, the skin care efficacy is comprehensively improved.

[0037] Furthermore, the natural penetration enhancers tea tree oil (containing terpenoid compounds) and lauryl alcohol derivatives (such as laurocapron) used in the present invention are derived from plant extraction, are similar to the lipid structure of the skin, can reduce damage to the skin barrier, reduce the risk of allergies or irritation, and also have antibacterial, antioxidant, repair and other multifunctional properties, further improving the skin's moisturizing, whitening and other properties.

[0038] The present invention also relates to a phytoestrogen-based skin care composition, which is prepared by the preparation method of the present invention.

[0039] The present invention provides an application of a phytoestrogen-based skin care composition in skin care products, wherein the composition is added to the skin care products, and the skin care products include any one of creams, emulsions, lotions, facial masks or lotions.

[0040] The present invention also relates to a delivery system of a phytoestrogen-based skin care composition, and the composition is prepared by the preparation method of the present invention.

[0041] The advantages or beneficial effects of the above technical solution include at least:

[0042] The delivery system of the present invention innovatively uses phospholipid-hydrazone bond-polyethylene glycol, chitosan, and ceramide as nanoemulsion carriers, and contains active ingredients of various functional ingredients such as phytoestrogen powder, moisturizers, whitening ingredients, and penetration enhancers, achieving efficient and stable delivery of phytoestrogen active ingredients, while showing synergistic effects in moisturizing, whitening, and anti-wrinkle. The skin care composition contained in the delivery system has a simple preparation process and high stability, and the product is light, easy to absorb, non-irritating, suitable for all skin types, and has significant market competitiveness and application prospects. DETAILED DESCRIPTION

[0043] In order to more clearly illustrate the purpose, technical solutions and advantages of the present invention, the technical solutions of the present invention will be described in detail through specific embodiments below. It should be pointed out that these embodiments are only used to illustrate the present invention, rather than to limit its protection scope. The actual protection scope of the present invention shall be based on the definition of the claims.

[0044] The materials and reagents used in the following examples and comparative examples are commercially available unless otherwise specified. The amounts of the components in the following examples are 1 g per part by weight or per portion unless otherwise specified.

[0045] Experimental Materials:

[0046] Phospholipid-hydrazone bond-polyethylene glycol 1#, DSPE-HYD-PEG, Xi'an Qiyue Biological, catalog number Q-0094638.

[0047] Phospholipid-hydrazone bond-polyethylene glycol 2#, DSPE-HYD-PEG2000, Guangzhou Weihua Biotechnology Co., Ltd., product number WH00164004.

[0048] Resveratrol was purchased from Shaanxi Angxu Biotechnology Co., Ltd., and its resveratrol purity was 98%.

[0049] Puerarin was purchased from Chengdu Pus Biotechnology Co., Ltd., and its puerarin product number was PS0180-5000, with a purity of 98%.

[0050] Soybean isoflavones were purchased from Hubei Jianchu Biopharmaceutical Co., Ltd., and the purity of soybean isoflavones was 98%, with the product number 964158. Example

[0051] An emulsion of a skin care composition comprising phytoestrogens, and its preparation method comprises the following steps:

[0052] (1) Preparation of the nanoemulsion carrier: According to the components and contents of the nanoemulsion carrier in Table 1, use a high-speed shearing machine to shear at 8000 r / min for 6 min, and then homogenize at 50 Mpa for 5 times to form the nanoemulsion carrier;

[0053] (2) Mixing of active ingredients: According to the components and contents of the active ingredients in Table 1, stir and mix evenly at 70 °C to obtain a mixture;

[0054] (3) Integration system: Add the mixture obtained in step (2) to the nanoemulsion carrier prepared in step (1), stir at 200 rpm and 70 °C for 1 h, add a penetration enhancer, and continue to stir for 1 h until completely dispersed to form a uniform skin care composition;

[0055] (4) Mix the emollient, thickener, plant extract, fragrance with the skin care composition in step (3) to obtain the emulsion.

[0056] Table 1: The mass parts (g) of each component in Examples 1-8 are as follows:

[0057]

[0058] Table 2: The mass parts (g) of each component in Comparative Examples 1-5 are as follows:

[0059] 。

[0060] Comparative Example 6

[0061] The raw material composition and mass parts are the same as those in Example 2. The difference from Example 2 is that in step (1), it is not subjected to high-speed shearing and homogenization treatment, and each component is stirred and evenly mixed to prepare an emulsion, and other conditions are the same as those in Example 2.

[0062] Performance evaluation:

[0063] 1. Transdermal penetration experiment of the sample

[0064] Using pig skin to simulate human epidermal skin, cut the pig skin into pieces of 5 cm * 5 cm with scissors, and then soak it in physiological saline for 30 min as the transdermal barrier. Use the Franz diffusion cell as a static diffusion cell, with the tested cosmetic as the transdermal release solution and 30% physiological saline as the transdermal absorption solution, and conduct the transdermal absorption test under the conditions of constant temperature of 36 °C and constant speed of 600 r / min. At the sampling point after 24 h, use a clean syringe to separately transfer 5 mL of the permeate, and then use a clean syringe to supplement 5 mL of 30% physiological saline. Determine the resveratrol content in the sample by high performance liquid chromatography.

[0065] Resveratrol permeation rate = (amount of resveratrol in the receiving pool / amount of resveratrol in the emulsion) × 100%.

[0066] Table 3: Results of in vitro transdermal absorption test

[0067] .

[0068] From the test results in Table 3, it can be found that the skin care product emulsion prepared in Example 2 of the present invention shows significantly higher in vitro transdermal permeation amount than that of the comparative example. It shows that in the present invention, the phospholipid-hydrazone bond-polyethylene glycol, chitosan, and ceramide form a nanoemulsion carrier, which is beneficial to the loading of active ingredients such as phytoestrogens. High-speed shearing and homogenization treatment are beneficial to the dispersion of the nanoemulsion carrier, effectively improving the skin penetration performance of phytoestrogen active ingredients, and then penetrating deep into the skin to fully exert their efficacy.

[0069] 2. Stability of the nanoemulsion carrier

[0070] In order to verify the influence of the nanoemulsion carrier on the stability of the skin care product emulsion, 50 ml of the emulsions of the examples and the comparative examples were placed in transparent glass bottles and placed under the conditions of 50 °C and 550 Lux. The appearance of the emulsion was inspected every week. Observe the color, transparency, layering, flocculation and other phenomena of the emulsion.

[0071] The test results are as follows. After 16 weeks of continuous observation, the skin care emulsions of Examples 1-8 and the emulsion of Comparative Example 5 did not show layering, flocculation or color change; the emulsion of Comparative Example 1 began to show slight flocculation at the 12th week and severe layering after 16 weeks; slight flocculation and a decrease in transparency also occurred in Comparative Examples 2-4 and 6 after the 16th week. This shows that the skin care combination of the present invention has better stability.

[0072] 3. Determination of long-acting moisturizing performance

[0073] Healthy female volunteers aged 35 to 55 years old were selected to use the skin care lotions provided by the examples and comparative examples respectively, with 5 people in each group. At 0 h, 1 h, and 4 h, a skin moisture tester (Corneometer CM825) was used to quantitatively detect the water content of the facial skin. By comparing the moisture changes before and after use, the long-term moisturizing ability of the product was evaluated to characterize whether phytoestrogens penetrated through the skin barrier and entered the deep layer of the skin. The moisture content and moisturizing rate were the average values of each group of subjects. Moisturizing rate after 1 h / % = water content at 1 h / water content at 0 h * 100; Moisturizing rate after 4 h / % = water content at 4 h / water content at 0 h * 100.

[0074] Table 4: Moisturizing performance test

[0075]

[0076] According to the test data in Table 4, the skin moisturizing rates of the skin care lotions of the examples and comparative examples were similar after 1 hour of use. However, after 4 hours of use, the lotion of the example could keep the skin water content stably above 60%, while the lotion of the comparative example led to a significant decrease in the skin water content. This may be because the penetration enhancer used in the example promoted the phytoestrogens to penetrate deep into the skin layer and continuously released active ingredients on the skin surface, thus achieving a long-term skin care effect.

[0077] 4. Whitening test

[0078] Experimental method: Healthy female volunteers aged 35 - 55 years old were selected to use the skin care products of the examples and comparative examples respectively, and used continuously for 30 days, once in the morning and once in the evening for each person in each group. A color difference meter was used to test and calculate the average value of the skin brightness change (△L) before and after use. The results are shown in Table 5.

[0079] Table 5: Whitening test results

[0080]

[0081] As shown in Table 5, the skin care lotions prepared in Examples 1 - 8 showed significant advantages in terms of skin brightness change (△L), had good whitening effects, and could promote the entry of phytoestrogen-like active ingredients into the basal layer of the skin, thus achieving the whitening effect. In contrast, less phytoestrogen active ingredients in Comparative Examples 1 - 6 entered the deep layer of the skin, and the long-term skin care effect provided on the skin surface was worse, resulting in a decrease in whitening performance.

[0082] 5. Anti-aging test

[0083] In this study, volunteers aged 30 - 50 were recruited as subjects and used the emulsions of the embodiments and comparative examples of the present invention respectively. There were 5 people in each group. Before the test started, the face was cleaned, and then the facial wrinkles were preliminarily tested using the American VISIA facial image analyzer. After that, the subjects in each group used the assigned product once every night. After continuously using the product for 1 month, 2 months, and 3 months, the VISIA facial image analyzer was used again to test the facial wrinkles, and the reduction effect of skin wrinkles was analyzed to evaluate the wrinkle removal effect of the products in each test group and calculate the reduction rate of facial wrinkles. The results of the wrinkle reduction rate for the anti-aging performance test of the products in each test group are as described in Table 6 below.

[0084] Table 6 Anti-aging performance test

[0085]

[0086] According to the anti-aging performance test results in Table 6, the emulsion prepared by the present invention performs excellently in anti-aging and reducing wrinkles. After continuous use for three months, the wrinkles on the facial skin are reduced by 40%, which is significantly better than Comparative Examples 1 - 6. It can be seen that the phospholipid-hydrazone bond-polyethylene glycol, chitosan, and ceramide form a nanoemulsion carrier, which is beneficial to the loading of active ingredients such as phytoestrogens, can promote the entry of phytoestrogen-like active ingredients into the basal layer of the skin, achieve a more long-lasting effect of repairing the skin, and significantly improve the wrinkle reduction rate.

[0087] 6. Evaluation of usage experience

[0088] To evaluate the experience of the product, a questionnaire survey was conducted on healthy female volunteers aged 35 - 55 after use. Each group was scored on a 5-point scale. The volunteers in each group used the emulsions of the embodiments and comparative examples respectively, continuously for 30 days, once in the morning and once in the evening every day. The volunteers recorded whether there were any discomfort symptoms such as itching, burning, or persistent skin redness.

[0089] According to the test results, none of the volunteers in the embodiments and comparative examples had discomfort or allergic reactions such as itching, burning, or persistent skin redness during use. At the same time, they generally reported that the product was gentle and comfortable, had a long-lasting moisturizing effect, could effectively brighten the skin tone and remove freckles, and the overall usage experience was very good.

[0090] The above embodiments are only examples provided to illustrate the present invention and are not limitations on the possible implementation manners of the present invention. Based on the content disclosed in the present invention, those skilled in the relevant art can make various forms of modifications and adjustments. It is impossible and unnecessary to list all possible implementation manners. Any modification, equivalent substitution, or improvement made within the basic principles and scope of the present invention shall be regarded as belonging to the protection scope of the present invention.

Claims

1. A method for preparing a skin care composition, characterized in that, Comprising the following steps: (1) Preparation of nanoemulsion carrier: Mix phospholipid-hydrazone bond-polyethylene glycol, chitosan, ceramide, emulsifier and an appropriate amount of water, and form a nanoemulsion carrier through high-speed shearing and homogenization treatment; (2) Active ingredient mixing: Disperse phytoestrogen powder, humectant, and whitening ingredient in water respectively, mix evenly to obtain a mixture of active ingredients; (3) Integrating the system: Add the mixture obtained in step (2) to the nanoemulsion carrier prepared in step (1), stir evenly, add a penetration enhancer, and continue to stir until completely dispersed to form a uniform skin care product composition; The high-speed shearing is carried out at 7000 - 10000 r / min for 1 - 15 min; the homogenization treatment is carried out at 10 - 100 Mpa for 1 - 10 times; The phytoestrogen powder includes any one of soy isoflavones, resveratrol, and puerarin.

2. The preparation method of the skin care composition according to claim 1, characterized in that, The phytoestrogen powder is a compound prepared from soy isoflavones, resveratrol, and puerarin in a mass ratio of 5 - 15:3 - 10:2 - 8.

3. The preparation method of the skin care composition according to claim 1, characterized in that, The number average molecular weight of the chitosan is 1000 - 5000 Da, and the degree of deacetylation > 90%; the emulsifier is at least one of polyoxyethylene castor oil emulsifiers, polyoxyethylene hydrogenated castor oil emulsifiers, polyglycerol emulsifiers, and glucoside emulsifiers.

4. The preparation method of the skin care composition according to claim 1, characterized in that, The humectant includes at least one of hyaluronic acid, glycerol, and butanediol; the whitening ingredient includes at least one of niacinamide, sialic acid, vitamin C, carnosine, and ellagic acid; the penetration enhancer is a natural penetration enhancer, and the natural penetration enhancer is at least one of tea tree oil and lauryl alcohol derivatives; the lauryl alcohol derivative is at least one of laurocapram, menthyl laurate, and polyethylene glycol laurate.

5. The preparation method of the skin care composition according to claim 1, characterized in that, The skin care composition further contains one or more additives selected from the group consisting of emollients, thickeners, plant extracts, pH regulators, fragrances, and combinations thereof.

6. The preparation method of the skin care composition according to claim 5, characterized in that, The emollient is at least one of squalane, jojoba oil, caprylic / capric triglyceride, polydimethylsiloxane, polydimethylsiloxanol, and hydrogenated polyisobutene; the thickener is at least one of xanthan gum, carbomer, sodium polyacrylate, and sodium carboxymethyl cellulose; the plant extract is at least one of licorice extract, aloe extract, dendrobium officinale extract, and centella asiatica extract; the pH regulator is at least one of disodium ethylenediaminetetraacetate, triethanolamine, and sodium citrate; the fragrance is selected from at least one of vanillin, menthol, rose essential oil, jasmine essential oil, carnation essential oil, gardenia essential oil, and violet essential oil.

7. The preparation method of the skin care composition according to claim 1, characterized in that, Relative to the total weight of the skin care composition, the content of the phospholipid-hydrazone bond-polyethylene glycol is 0.01-3 wt%, the content of the ceramide is 0.05-1.5 wt%; the content of the phytoestrogen powder is 1-10 wt%, the content of the chitosan is 0.01-0.5 wt%, the content of the emulsifier is 0.5-5.0 wt%, the content of the humectant is 1-5 wt%, the content of the whitening ingredient is 0.5-2 wt%, and the content of the penetration enhancer is 0.1-5 wt%.

8. A skin care composition, characterized in that, This skin care composition is prepared by the preparation method of the skin care composition according to any one of claims 1-7.

9. Use of the skin care composition according to claim 8 in skin care products, characterized in that, The skin care product includes any one of creams, lotions, aqueous solutions, facial masks or lotions.

10. A delivery system for a skin care composition, characterized in that, The delivery system includes the skin care composition according to claim 8 or the skin care composition prepared by the preparation method of the skin care composition according to any one of claims 1-7.

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