Composition containing powder raw materials for dispelling effects of alcohol and improving liver function and preparation method thereof

Abstract

The present invention relates to a composition for alleviating hangover and improving liver function containing L-ornithine, and a preparation method therefor, according to the present invention, the composition has a small burden on the human body while exhibiting a sufficient hangover alleviating effect. Thus, embodiments of the present invention provide effects of understanding alcohol and improving liver function.

Description

Technical Field

[0001] The following examples relate to a composition for relieving hangover and improving liver function containing powder raw materials and a method for preparing the same. Background Art

[0002] Approximately 10% of the ethanol absorbed by drinking is excreted from the body through respiration or urine, and the remaining 90% is metabolized in the digestive tract or the liver. Alcohol metabolism occurs in the liver, where ethanol is oxidized to acetaldehyde by alcohol dehydrogenase (ADH), and the acetaldehyde is oxidized to acetic acid by aldehyde dehydrogenase (ALDH). All these oxidation processes require NAD (nicotinamide adenine dinucleotide). The resulting acetic acid is converted to carbon dioxide and water through acetyl coenzyme A. The carbon dioxide is excreted from the lungs, and the water is excreted from the body through urine. Excessive drinking can cause a hangover, which causes alcohol and acetaldehyde to accumulate in the human body and act as the main toxic substances in various organs, leading to headaches, fatigue, sensitivity to light and sound, muscle pain, bloodshot eyes, thirst, chills, vomiting, and stomachaches, etc., which will have a negative impact on the human body.

[0003] To relieve this hangover, functional beverages or compositions have been developed in Korean Patent Publication No. 10-0853078, especially functional beverages containing ingredients extracted from natural ingredients, and these functional beverages can be consumed alone after drinking or added to high-alcohol-content alcohol before drinking. However, the hangover-relieving effect is still not very good. In addition, beverages containing certain herbs may cause symptoms such as abdominal distension and abdominal pain, so there is a controversy about whether they are harmful to the human body. Therefore, it is necessary to develop a composition with less burden on the human body and sufficient hangover-relieving effect at the same time.

[0004] [Prior Art Documents]

[0005] [Patent Documents]

[0006] [Patent Document 1] Korean Patent Publication No. 10-0853078. Summary of the Invention

[0007] Technical Problem to be Solved

[0008] In view of the above-mentioned many problems, the present invention is proposed, and its purpose is to provide a composition for relieving hangover and improving liver function with less burden on the human body and a method for preparing the same.

[0009] Technical Solution

[0010] To achieve the above object, an embodiment of the present invention provides a food composition for relieving hangover and improving liver function, which is selected from one or more lactic acid bacteria of L-ornithine, potassium citrate, cabbage powder, non-skin polyporus, and Lactobacillus, and a method for preparing the same.

[0011] An embodiment of the present invention provides a method for preparing a food composition for relieving a hangover and improving liver function, which includes: a step of extracting and drying cabbage to prepare cabbage powder; and a step of mixing one or more lactic acid bacteria selected from L-ornithine, potassium citrate, Phellinus linteus, and Lactobacillus into the cabbage powder.

[0012] Advantageous effects

[0013] According to the present invention, it has the advantages of imposing a small burden on the human body and simultaneously exerting a sufficient hangover effect. Therefore, the embodiments of the present invention provide the effects of relieving a hangover and improving liver function. Detailed description of specific embodiments

[0014] Hereinafter, embodiments will be described in detail with reference to the accompanying drawings. However, various changes can be made to the embodiments, so the scope of the patent application is not limited or restricted by these embodiments. All changes, equivalents, or substitutions to the embodiments should be understood to be included within the scope of the rights.

[0015] The specific structural or functional description of the embodiments is disclosed only for the purpose of example and can be changed and implemented in various forms. Therefore, the embodiments are not limited to the specific forms disclosed, and the scope of this specification includes variations, equivalents, or substitutes included in the technical idea.

[0016] Although terms such as first or second can be used to describe various components, these terms should only be interpreted as distinguishing one component from another. For example, the first component can be named the second component, and similarly, the second component can also be named the first component.

[0017] When it is mentioned that one component is "connected" to another component, it should be understood as being directly connected to or connected to another component, but there may be another component in the middle.

[0018] The terms used in the embodiments are only for the purpose of description and should not be construed as being intended to limit. Singular expressions include plural expressions unless the context clearly indicates otherwise. In this specification, the terms "include" or "have" are intended to specify the presence of the features, numbers, steps, actions, components, parts, or combinations thereof listed in the specification, and should not be construed as precluding the possibility of the existence or addition of one or more other features, numbers, steps, actions, components, parts, or combinations thereof.

[0019] Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by those of ordinary skill in the technical field to which the embodiments belong. Unless clearly defined in this application, terms defined in a common dictionary should be interpreted as having a meaning consistent with the context of the related art and should not be interpreted as ideal or overly formal meanings.

[0020] Advantages, features, and implementation methods of the present invention will become clear by referring to the embodiments described in detail below in conjunction with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below, but will be implemented in various different forms, and only these embodiments ensure that the disclosure of the present invention is complete, and in the technical field to which the present invention belongs, the present invention is provided to fully inform a person with common sense of the category of the present invention, and the present invention is only defined by the category of the claims.

[0021] In embodiments of the present invention, unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by those of ordinary skill in the technical field to which the present invention belongs. Terms defined in a common dictionary should be interpreted as having a meaning consistent with the meaning in the relevant technical context unless explicitly defined in embodiments of the present invention, and should not be interpreted as ideal or overly formal meanings.

[0022] To illustrate embodiments of the present invention, the shapes, sizes, proportions, angles, quantities, etc. disclosed in the accompanying drawings are exemplary, and thus the present invention is not limited to what is shown. In addition, when explaining the present invention, if it is determined that a detailed description of related publicly known technologies may unnecessarily obscure the gist of the present invention, the detailed description thereof is omitted. When using "comprising", "having", "accomplishing", etc. mentioned in this specification, other parts may be added unless "only" is used. If a component is expressed in the singular, it includes the case of including a plural number unless otherwise clearly stated.

[0023] When interpreting components, even if there is no separate explicit record, they are interpreted as including an error range.

[0024] The sizes and thicknesses of each structure shown in the accompanying drawings are shown for convenience of description, and the present invention is not necessarily limited to the sizes and thicknesses of the structures shown.

[0025] Each feature of multiple embodiments of the present invention can be partially or fully combined with each other or combined, and as can be fully understood by those skilled in the art, various interconnections and drivings are possible technically, and each embodiment can be implemented independently of each other or implemented together in a related relationship.

[0026] Hereinafter, the present invention will be described in detail with reference to embodiments and the accompanying drawings. However, it is obvious that the present invention is not limited by the following embodiments and the accompanying drawings.

[0027] Hangover relief and liver function improvement

[0028] Existing hangover remedies mainly consist of substances that assist liver metabolism. However, there is a problem in that substances corresponding to chronic reactions caused by alcohol consumption often have insignificant effects during the acute phase and relatively small effects. Therefore, the present inventors have invented the present invention which is necessary to eliminate the main factors causing hangovers from a medical perspective by analyzing the acute reactions of the liver, gastrointestinal tract, and blood during heavy drinking, and to minimize the effects of alcohol absorption in the order of gastrointestinal tract - liver - blood. More specifically, in the process of inhibiting absorption - promoting metabolism (decomposition) - alleviating systemic symptoms - promoting excretion, 1) strengthen the decomposition of alcohol in the gastrointestinal tract, 2) inhibit the absorption of alcohol in the gastrointestinal tract, 3) the alcohol metabolism efficiency in the liver and inhibit hangover-inducing substances, and 4) minimize the effects of alcohol in the blood on the whole body.

[0029] Approximately 10% of the ethanol (full name ethanol) absorbed from drinking is excreted from the body through respiration or urine, and of the remaining 90%, 20% is absorbed from the stomach and 80% is absorbed from the small intestine. Alcohol absorbed from the gastrointestinal mucosa does not require a special receptor, so it can be quickly absorbed into the liver through the blood. When it mixes with the blood in the portal vein and hepatic arteriole, it is exposed to hepatocytes, undergoes metabolism, and is absorbed by the central artery. The alcohol passing through this pathway is oxidized in the hepatocytes and converted into non-toxic acetate and used as energy (about 7.1 calories per gram of alcohol). Due to the limited metabolic rate of hepatocytes, the remaining unmetabolized alcohol enters the blood, resulting in an increase in blood alcohol concentration. The remaining unoxidized alcohol enters the blood, circulates throughout the body, and then is metabolized in the liver again, so excessive drinking leads to an increase in blood alcohol concentration. Alcohol easily crosses cell membranes and mixes well with cell lipid membranes, so it interferes with normal cell signal transmission. In addition, alcohol diffuses to multiple organs through the systemic circulation, manifesting as systemic symptoms. More than 90% of the absorbed alcohol is metabolized to acetaldehyde in the liver, and the processing rate is about one glass per hour.

[0030] In alcohol metabolism, the primary metabolic process mainly involves 1) the alcohol dehydrogenase (antidiuretic hormone) system, 2) the microsomal ethanol oxidizing system (MEOS), and 3) the catalase system. Among them, the clinically important pathways are 1) and 2). Pathway 1) is the main pathway for alcohol decomposition, corresponding to the pathway in which ethanol is oxidized to acetaldehyde by alcohol dehydrogenase present in the cytoplasm of hepatocytes. The intermediate acetaldehyde is a very unstable and highly toxic substance and is one of the main factors causing liver damage (resulting in hangovers such as flushing or varicose veins on the face, headache, and vomiting). The acetaldehyde is rapidly converted to acetic acid by aldehyde dehydrogenase (ALDH) present in the mitochondria (secondary metabolic process). The metabolism of acetaldehyde occurring in the mitochondria is rapid, but it occurs more slowly in Asians with a relatively high number of aldehyde dehydrogenase mutations, leading to the accumulation of acetaldehyde, which is considered the main cause of hangovers. When the concentration of acetaldehyde increases, various hangover symptoms and inflammatory reactions occur. Pathway 2) accounts for 10% to 20% of alcohol metabolism and is a pathway for metabolizing various drugs. When alcohol is not sufficiently metabolized through the alcohol dehydrogenase pathway and ethanol is oxidized to acetaldehyde, the above-mentioned pathway 2) occurs. With long-term repeated drinking, the ability of the enzyme increases by 5 to 10 times, and one may feel that their alcohol tolerance has increased. More specifically, two electrons in reduced coenzyme II are transferred to the membrane protein CYP2E1 (cytochrome P450) located on the cytoplasmic membrane of hepatocytes, and ethanol attaches to CYP2E1 and is oxidized to acetaldehyde. During this process, reactive oxygen species (ROS) are generated. The reactive oxygen species are converted to hydrogen peroxide (H2O2) which attacks the cell membrane (lipids), inhibits the electron transport system and the process of oxidative phosphorylation. Therefore, the cells undergo inflammatory reactions and die, and long-term exposure to reactive oxygen species can lead to diseases such as cirrhosis. In the secondary metabolic process of alcohol metabolism, if a large amount of the intermediate acetaldehyde accumulates, it cannot be converted to acetic acid at a rate exceeding a certain level, so it diffuses into the blood and systemic symptoms (hangover symptoms such as vomiting, flushing, nausea, etc.) appear. Acetaldehyde is metabolized to the final oxide acetate by aldehyde dehydrogenase in the mitochondria.

[0031] In the primary / secondary metabolic process, the reduced form of coenzyme I (NADH) increases, thus increasing the ratio of NADH / NAD + The increase in the reduced form of coenzyme I leads to metabolic disorders. In the normal aerobic metabolic process, carbohydrates / fats / proteins are metabolized in the tricarboxylic acid cycle to produce the reduced form of coenzyme I, which is then converted to adenosine triphosphate to generate energy. When drinking alcohol causes an increase in the reduced form of coenzyme I, the normal aerobic metabolic process is inhibited in the opposite direction. Due to the abundance of the reduced form of coenzyme I, the metabolic processes (glycolysis / gluconeogenesis / tricarboxylic acid cycle (energy production) / fatty acid oxidation) proceed in the direction of inhibiting energy production. Therefore, energy production is inhibited and hypoglycemia occurs. Alcohol metabolism leads to the accumulation of acetic acid, thus causing the accumulation of fat, and the production of lactic acid, thus causing the accumulation of fatigue. Fasting blood glucose is lower than or maintained at a level lower than normal, and postprandial blood glucose increases.

[0032] In addition, alcohol consumption has a diuretic effect, leading to potassium deficiency. As a result, the cell's response to reactive oxygen species decreases, and the decline in adenosine triphosphate (ATP) production is exacerbated. Due to potassium depletion, alcohol interferes with the secretion of antidiuretic hormone produced by the posterior pituitary gland and exacerbates hyponatremia. For example, the loss of potassium stimulates antidiuretic hormone activity, increasing the amount of body fluid reabsorbed and thus reducing the sodium concentration in the body. In addition, the loss of potassium also increases thirst through hormonal mechanisms, thereby increasing water intake. When extracellular fluid (ECF) is potassium-deficient, potassium moves from intracellular fluid (ICF) to extracellular fluid due to the concentration difference. Therefore, the potassium in the cytoplasm decreases. At the same time, the inner mitochondrial membrane is not very permeable to cations, but a certain amount of potassium flows into the mitochondrial matrix depending on the concentration difference. The influx of potassium keeps the mitochondria in volume, keeps the membrane tight and maintains the potential difference. When cytoplasmic potassium decreases, the outward flow of K + out of the mitochondria decreases, resulting in insufficient mitochondrial potassium. This often leads to an overall decline in mitochondrial functions including energy production. In this way, poor ATP synthesis and poor cell respiration are likely to form reactive oxygen species. In the N-antidiuretic hormone / NAD + highly reduced state, excess electrons are easily transferred to and combined with oxygen, making it more likely to produce reactive oxygen species. In addition, a large amount of reactive oxygen species is also produced during the decomposition of alcohol through the microsomal ethanol oxidizing system (MEOS) caused by excessive alcohol consumption. Reactive oxygen species can cause inflammation, aging, cancer and degenerative diseases. Under stress conditions that produce reactive oxygen species, the mitochondrial ATP-dependent potassium channel is activated, introducing potassium into the mitochondrial matrix. This reduces the membrane potential difference and the production of superoxide anions, thus inhibiting the production of reactive oxygen species. Therefore, maintaining the potassium concentration in the cytoplasm is expected to inhibit the production of reactive oxygen species, thereby inhibiting the inflammatory response and restoring normal mitochondrial function. Since acetaldehyde is decomposed by aldehyde dehydrogenase in the mitochondria, it is also expected to become active. Supplementation with potassium is expected to inhibit the inflammatory response and the production of acetaldehyde, which are considered the main causes of hangover.

[0033] Therefore, the present inventors found that: 1) the blood ethanol concentration reaches its maximum value 60 to 90 minutes after drinking and decreases over time; 2) the blood acetaldehyde reaches its maximum concentration within 1 hour after drinking; 3) the hangover reaches its maximum value 12 to 14 hours after drinking (at this time, alcohol and acetaldehyde are almost metabolized), and the direct cause of the hangover is cytokines in the blood rather than alcohol and acetaldehyde. In particular, the present inventors found that the expression time of cytokines after alcohol stimulation is consistent with the expression time of the hangover, and healthy people will show hangover-like symptoms such as gastrointestinal disorders, headache, chill, fatigue and vomiting after injection of cytokines. Therefore, the present inventors hypothesized that the main factors of the hangover are IL-10 and IL-12-mediated immunosuppression of cellular immunity (IL-10, IL-12).

[0034] Fatigue recovery

[0035] On the one hand, the present invention provides a food composition for restoring fatigue. Ammonia well reflects the fatigue during exercise. The central fatigue mechanism of ammonia means that when a large amount of toxic ammonia accumulates, motor dysfunctions such as sleep, convulsions, movement disorders, coma, etc. will occur. The peripheral fatigue mechanism is that the accumulation of ammonia in muscles will stimulate the centripetal nerve related to muscle pain perception, thus leading to fatigue. The composition of the present invention can reduce the concentrations of fatigue substances such as ammonia, cortisol and lactic acid in the blood, and rapidly increase the concentration of hydrogen ions pH, so it can show the effect of rapidly improving post-exercise fatigue.

[0036] Food composition for hangover relief and liver function improvement

[0037] In one aspect, the present invention provides a food composition for relieving a hangover and improving liver function, which is selected from one or more of L-ornithine, potassium citrate, cabbage powder, and lactic acid bacteria including Pediococcus pentosaceus and Lactobacillus.

[0038] In particular, when the above components are included as active ingredients in the composition, the present inventors have completed the present invention with less burden on the human body and at the same time showing a sufficient hangover relief effect, and by applying safe substances approved as foods, a method for solving a hangover from a medical perspective has been found. The composition of the present invention can be used for relieving a hangover and improving liver function.

[0039] In the present invention, the term "extract" refers to an active ingredient separated from natural products, which can be obtained through an extraction process using water, an organic solvent or a mixed solvent thereof, including an extract, its dry powder or any form formulated with it. The extracted liquid can be used immediately, or concentrated and / or dried and used as a "powder". When extracting with an organic solvent, methanol, ethanol, isopropanol, butanol, ethylene, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate, dichloromethane, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), 1,3-butanediol, propylene glycol or a mixed solvent thereof can be used. Under the condition that the active ingredient is not damaged or minimized, extraction can be carried out at room temperature or with heating. The extraction degree and loss degree of the active ingredient of the medicinal material may vary depending on the organic solvent used for extraction, so please select and use a suitable organic solvent. The extraction method is not particularly limited, such as hot water extraction, cold soaking extraction, ultrasonic extraction and reflux extraction.

[0040] The solvent extract may further include the step of filtering the extract to remove floating solid particles. Cotton, nylon, etc. can be used to filter the particles, and ultrafiltration, freeze filtration, centrifugation, etc. can also be used, but are not limited thereto. When concentrating the extract, methods such as vacuum concentration and reverse osmosis concentration can be adopted. The drying step after concentration includes, but is not limited to, freeze drying, vacuum drying, hot air drying, spray drying, vacuum drying, foam drying, high-frequency drying, infrared drying, etc.

[0041] The composition according to the present invention: 1) inhibits the absorption of alcohol, 2) activates the decomposition of alcohol and its by-products, and 3) inhibits the inflammatory response caused by alcohol and its by-products. More specifically, the composition of the present invention inhibits the absorption of the gastrointestinal tract when drinking excessively, promotes the decomposition of the liver, inhibits the production of pro-inflammatory substances, maintains the liver function in the best state, and has the effect of promoting metabolism. Since the composition of the present invention is taken during or immediately after drinking, it has particularly excellent short-term effects in solving the phenomena occurring in the acute phase.

[0042] The inventor named the composition of the present invention with the effects of relieving hangover and liver function "Morning WOW".

[0043] * The "active ingredient" refers to an ingredient that exhibits the expected activity or an ingredient that can exhibit activity together with a carrier that is inactive by itself.

[0044] The "L-ornithine" is an alkaline amino acid that plays an important role in the urea cycle. In the elemental circuit, L-ornithine flows from the cytoplasm into the mitochondria, captures ammonia in the mitochondria, synthesizes L-citrulline, and then is released into the cytoplasm to become arginine. This plays a role in removing nitrogen from the mitochondria. Arginine receives the second amino group of the element from aspartic acid. The carbonyl group of aspartic acid disappears as fumaric acid, and the amino group is transferred to arginine to synthesize harmless elements. After that, the elements are excreted through the kidneys. The two representative circuits that function in the body include the citric acid cycle (tricarboxylic acid cycle) that generates energy and the elemental circuit that processes ammonia. The citric acid cycle occurs inside the mitochondria, and the elemental circuit occurs on the cytoplasm + mitochondria. These two circuits share intermediate metabolites (argininosuccinate shunt) and use part of the adenosine triphosphate (4 adenosine triphosphate) generated by the citric acid cycle in the urea cycle. Amino acids produce toxic substances ammonia (nitrogen compounds) as metabolites, and ammonia is converted into harmless elements through the elemental circuit and excreted through the kidneys.

[0045] Under drinking conditions, antidiuretic hormone preferentially decomposes alcohol over the mitochondrial metabolism of other nutrients, resulting in the accumulation of N antidiuretic hormone, and the ratio of N antidiuretic hormone / NAD + increases. This slows down the conversion of NAD +The tricarboxylic acid cycle that is converted to N-vasopressin. Oxaloacetate in the tricarboxylic acid cycle accepts the amino group of glutamate, becomes aspartate, and transfers the amino group to the urea cycle through argininosuccinate. However, in the case of drinking alcohol, the N-vasopressin / NAD + level is high, so aspartate produces acetate through oxalic acid to reduce N-vasopressin. As a result, the amino group of aspartate cannot be transferred to the urea cycle, but is transferred to α-ketoglutarate, resulting in the production of glutamate. Therefore, the clearance of amino groups in hepatocytes is reduced, and ammonium ions are expected to accumulate, which is related to mitochondrial dysfunction. The present invention supplements ornithine that enters the mitochondria and captures nitrogen.

[0046] The L-ornithine directly enters the mitochondria, captures ammonia nitrogen, is converted into citrulline, and is excreted outside the mitochondria. That is, the function is to extract it into the cytoplasm. In the case of reduced ammonia clearance due to an increase in blood alcohol concentration, L-ornithine has a direct effect on ammonia clearance. In addition, by supplying carbon dioxide required for carbamoyl phosphate generated during the transfer of ammonia to ornithine into the mitochondria, it is expected to maximize the denitrification effect of ornithine. The focus of the present invention is to normalize the mitochondria by preventing the accumulation of amino groups in the mitochondria. For this purpose, potassium citrate is supplemented to supplement the carbon dioxide generated due to the slowdown of the tricarboxylic acid cycle. With the effective removal of ammonia in the mitochondria, the decomposition of acetaldehyde in the mitochondria is normalized, resulting in a reduction in the production of reactive oxygen species, a virtuous cycle, normalization of the mitochondria, and finally, the decomposition of acetaldehyde by acetaldehyde dehydrogenase in the mitochondria plays out.

[0047] The "potassium citrate" is an alkaline organic salt compound used as an alkalizing agent. Potassium citrate has a buffering effect on gastric acid, which is considered to be manifested in carbonic acid after being absorbed by chloride ions. The potassium citrate is 90% ionized at physiological pH, and the ionized citric acid acts as a trivalent anion. In our body, carbonate ions (HCO3-) and hydrogen ions (H + ) in the blood are converted into water and carbon dioxide to form an equilibrium (HCO3- + H + <-> H2O + CO2). Citric acid released into the blood exhibits the effect of combining with H + and releasing HCO3- released into the blood, so it acts as a base. This can prevent lactic acidosis in the blood, which is caused by the production of lactic acid after excessive drinking, and thus is expected to prevent one of the causes of hangovers. Potassium citrate is rapidly absorbed through the gastrointestinal tract. Substances absorbed from the gastrointestinal tract directly enter the liver and enter hepatocytes. In the case of excessive drinking, near hepatocytes where the production of lactic acid makes it acidic, citric acid is better ionized and captures H +, releases HCO3−, increases the blood pH value, and normalizes the blood pH value. At the same time, due to the good gas permeability of the inner mitochondrial membrane, the CO2 generated during this process can diffuse smoothly into the inner part of the inner mitochondrial membrane. Potassium citrate directly supplies carbon dioxide and potassium to hepatocytes. In order to convert nitrogen into elements in the elemental circuit, NH 4+ and carbon dioxide must react in the mitochondria to form carbamoyl phosphate. Since the tricarboxylic acid circuit does not operate smoothly when drinking alcohol excessively and less CO2 is generated, it can be predicted that a smooth supply of external CO2 is required to activate the elemental circuit. At this time, the citric acid in potassium citrate reacts with H + to generate water and carbon dioxide, and the carbon dioxide flows into the cell and temporarily forms hypercapnia. Therefore, carbon dioxide smoothly passes through the inner mitochondrial membrane and provides the carbon dioxide required for the formation of carbamoyl phosphate. Therefore, potassium citrate activates the metabolic process in which L-ornithine captures ammonia in the mitochondria and is converted into citrulline. Thus, it can be expected to have the effects of preventing ammonia accumulation in hepatocytes, normalizing mitochondria, and promoting the clearance of acetaldehyde.

[0048] Potassium is excreted in large amounts due to drinking. Since the potassium in the extracellular fluid decreases and extracellular shift occurs, the cell introduces potassium into the cell through Na / K ATPase, and the cell uses more ATP. Hepatocytes require K + to cope with the reactive oxygen species generated during the alcohol decomposition process, but potassium is secreted when drinking alcohol, so it faces a lack.

[0049] For hepatocytes that are more difficult in the reactive oxygen species reaction due to potassium deficiency, hepatocyte activation can be achieved by supplementing potassium. The potassium citrate is absorbed faster through the gastrointestinal tract than other potassium-containing preparations, so it is absorbed within a few hours and has the effect of quickly reaching hepatocytes and directly supplying potassium to hepatocytes. The supply of potassium can reduce the reactive oxygen species generated in the mitochondria, thereby reducing the future inflammatory reaction caused by reactive oxygen species. Therefore, it can be expected to help relieve the hangover after drinking. At the same time, due to the characteristic that citric acid reacts with H + at a lower pH value, it can also be expected to increase the pH value of the stomach by reacting with H + in the stomach. When drinking alcohol, too much gastric acid is secreted, and neutralizing gastric acid is expected to relieve symptoms such as stomachache, shivering, and vomiting that appear immediately after drinking.

[0050] The present inventor uses potassium citrate as an active ingredient to directly introduce K + to prevent the depletion of hepatocyte K + . At the same time, citrate can also activate the elemental circuit by providing carbon dioxide, thereby acting together with the L-ornithine. In particular, the potassium citrate is absorbed faster through the gastrointestinal tract than other components, so it can quickly reach hepatocytes, so it is very helpful for alcohol decomposition.

[0051] The above-mentioned "cabbage powder" is a component that protects the stomach when drinking alcohol. It can be obtained by chopping, drying, removing moisture from cabbage, and then pulverizing it. The cabbage powder is a natural anti-ulcer food, containing components that protect and strengthen the gastric mucosa, effective in preventing cancers such as gastric cancer and colon cancer. It is also rich in dietary fiber, low in calories, helpful for dieting, preventing constipation, and preventing skin aging. The present inventor uses cabbage powder as an active ingredient, which not only has the effect of protecting the gastric mucosa, but also has the effects of inhibiting alcohol absorption of dietary fiber, antioxidant / anti-inflammatory effects, and promoting acetaldehyde decomposition. In addition, sulforaphane contained in the cabbage powder has excellent antioxidant effects, alleviating cell stress effects, and anti-inflammatory effects when inducing cellular oxidative stress. In addition, sulfadiazine induces the decomposition of acetaldehyde by activating the subtype serum lactate dehydrogenase of acetaldehyde dehydrogenase that is usually inactivated in the salivary gland, so it helps those who have difficulty decomposing acetaldehyde due to acetaldehyde dehydrogenase gene mutation. The acetaldehyde dehydrogenase mutation in Koreans is estimated to account for about 30% of the population. Therefore, it can effectively reduce the oxidative stress of hepatocytes caused by reactive oxygen species during excessive drinking and reduce the resulting inflammation by promoting acetaldehyde decomposition.

[0052] Alcohol flows through the blood to the large intestine, making the alcohol concentration in the blood equal to that in the large intestine. That is, 30 to 90 minutes after drinking, when the alcohol concentration in the blood reaches its maximum value, the alcohol concentration in the intestine also reaches its maximum value. In the colon, the antidiuretic hormone of Escherichia coli undergoes alcohol-acetaldehyde metabolism and produces acetaldehyde. Among the total number of intestinal bacteria, the activity of acetaldehyde dehydrogenase is very low compared to the antidiuretic hormone, so the acetaldehyde concentration in the intestine is the highest in the body. It takes more than 9 hours for the generally ingested food to reach the large intestine, and acetaldehyde is produced before lactic acid bacteria are transmitted to the large intestine along with the food. It can be expected that the elimination of acetaldehyde on the day of drinking will not be greatly affected by the lactic acid bacteria ingested before drinking. Therefore, cabbage is a kind of dietary fiber that can activate the overall intestinal movement, accelerate the intestinal movement speed, speed up the defecation speed, reduce the absorption of the already produced acetaldehyde into the blood, form a volume, and promote intestinal movement. Cabbage containing a large amount of fiber is very useful. In particular, heat-treated cabbage powder effectively treats hepatitis inflammation by reducing the expression of the inflammatory mediators inducible nitric oxide synthase and cyclooxygenase-2 and the pro-inflammatory cytokine IL-1β, which are involved in the acute inflammatory response accompanying liver injury. The cabbage powder used in the present invention is used after heat treatment at about 121°C. In addition, the representative anti-peptic ulcer factor MMSC (s-methylmethionine chlorosulfonate) in cabbage promotes the production of the local hormone prostaglandin secreted by the gastric mucosa and secretes it into the gastric cavity, endowing the gastric mucosa with the ability to resist gastric acid or other attacking factors.

[0053] As described above, the cabbage powder used in the present invention is heat-treated cabbage powder, rather than the juice obtained from freeze-dried cabbage, and contains insoluble dietary fiber. Therefore, in addition to the effect of cabbage in inhibiting acute gastritis, the insoluble dietary fiber can also play the roles of absorbing water, increasing the fecal volume, shortening the transit time through the intestine, preventing constipation and enteritis. Since the lactic acid bacteria used in the present patent material are mixed with dietary fiber, the initial alcohol decomposition caused by the antidiuretic hormone of lactic acid bacteria can also be expected. Therefore, alcohol does not produce an anti-inflammatory effect in the stomach, but is absorbed in the small intestine, which is the main absorption site of alcohol, thereby reducing the alcohol absorption rate, and is expected to decompose the alcohol of lactic acid bacteria mixed with cabbage and promote the excretion effect. It also has the effects of reducing reactive oxygen species generated in the liver, promoting the decomposition of acetaldehyde, and reducing the inflammatory response, so it is expected to help relieve a hangover.

[0054] Almost all strains of the "Bifidobacterium" and "Lactobacillus" have the ability to decompose alcohol and / or acetaldehyde. Therefore, when taken together with dietary fiber cabbage, the alcohol decomposition effect in the initial stage of drinking can be achieved by decomposing the alcohol absorbed by cabbage.

[0055] The "Bifidobacterium" is Gram-positive, non-motile, and is generally classified as an anaerobic bacterium. It is present in the gastrointestinal tract, vagina and oral cavity of mammals. Bifidobacterium is one of the main bacterial genera that make up the mammalian colonic flora. Bifidobacterium organisms are commercially available and sold as probiotics for human consumption. For example, Dr. 's Complete Probiotic Capsules contain 70 billion organisms, including three Bifidobacterium. Other commercially available Bifidobacterium are also commercially available (e.g., Bifidobacterium infantis 35624). Any Bifidobacterium species that can be used in the present invention may be suitable. These species are known to live and function in the human digestive system and are known to be safe for human consumption. The systems used in the methods and compositions of the present invention include, without limitation, Bifidobacterium infantis, Bifidobacterium breve, Bifidobacterium adolescentis, Bifidobacterium animalis, Bifidobacterium pseudolongum, Bifidobacterium thermophilum, Bifidobacterium indicum, Bifidobacterium asteroides, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium coagulans, Bifidobacterium dentium, Bifidobacterium infantis, Bifidobacterium animalis subsp. lactis, and Bifidobacterium.

[0056] The "Lactobacillus" is a Gram-positive facultatively anaerobic or microaerophilic rod-shaped bacterium. This genus constitutes the main part of the group of bacteria (lactic acid bacteria) that convert lactose and other sugars into lactic acid. It is present in the human gastrointestinal tract and vagina. Certain Lactobacillus strains have potential therapeutic properties, including anti-inflammatory and anti-cancer abilities. In addition, the Lactobacillus promotes the healing of gastric ulcers. There are various commercial sources of lactic acid bacteria (e.g., from Cromwell, Connecticut Healthcare 30-Count Capsules or Digestive Health 30-Count Capsules for sale; GNC's Nutrition Sutang tablets of Lactobacillus; From Fumengte (Lactobacillus acidophilus capsules). Any species of Lactobacillus that can be used in the present invention may be suitable because strains of this genus are known to live and function in the human digestive system and are known to be edible by humans. The strains used in the methods and compositions of the present invention include, without limitation, Lactobacillus acidophilus (e.g., Lactobacillus acidophilus DDS-1, Lactobacillus acidophilus LA-5, Lactobacillus acidophilus NCFM), Lactobacillus bulgaricus, Lactobacillus jugurti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus casei, Lactobacillus plantarum, Lactobacillus salivarius, Lactobacillus rhamnosus (e.g., Lactobacillus rhamnosus A), L. paracasei, Lactobacillus lactis, Lactobacillus infantis, and Lactobacillus brevis.

[0057] The "Bifidobacterium" and "Lactobacillus" are representative genera used as probiotic lactic acid bacteria. The strength of the acid, the time of exposure to the acid, and the strain type are the main factors affecting the survival of lactic acid bacteria in the gastrointestinal tract, among which "non-Pidotia" and "Lactobacillus" survive in an acidic environment and are thus widely used in lactic acid bacteria products. In particular, Lactobacillus acidophilus and Bifidobacterium longum survive better in the stomach and adhere better to the gastric mucosa.

[0058] Alcohol is mainly absorbed in the small intestine, causing barrier damage. Lactobacilli can improve barrier damage, reduce endotoxin absorption, and thus alleviate liver injury. Oxidative stress induced by alcohol in the intestine disrupts the tight junctions of intestinal epithelial cells and increases intestinal permeability. Acetaldehyde also damages the microvessels within intestinal epithelial cells and increases intestinal permeability. When intestinal permeability increases, endotoxin in the cell walls of Gram-negative bacteria present in the intestine enters the bloodstream, promoting the secretion of inflammatory cytokines such as TNF-a, IL-1, and IL-6, leading to hepatocyte injury (https: / / koreascience.kr / article / JAKO201409649928775.pdf). Such inflammatory cytokines are also present in alcohol metabolism, and it is expected that increased intestinal permeability caused by alcohol consumption will lead to aggravated liver injury. Therefore, the lactic acid produced by lactobacilli proliferates intestinal stem cells and regenerates intestinal mucosal epithelial cells. "Pediococcus pentosaceus" and "Lactobacillus" used as ingredients in this patent have excellent gastric acid tolerance, so they can produce lactic acid in the small intestine, proliferate intestinal stem cells, and restore the intestinal mucosa damaged by alcohol consumption. Therefore, it can be expected to help reduce liver injury caused by excessive alcohol consumption and relieve a hangover. It takes time for food to reach the large intestine. Acetaldehyde is produced immediately after drinking in the large intestine and reaches its maximum concentration before the food reaches the large intestine. The degree of alcohol decomposition in the initial stage of drinking determines the degree of hangover the next day. Therefore, the lactobacilli used in this invention focus on contributing to the repair of small intestine injury, rather than mainly decomposing acetaldehyde by lactobacilli that occurs in the later stage of drinking, such as "Lactobacillus" with good gastric acid tolerance and a large amount of "Pediococcus pentosaceus" in the large intestine. Therefore, the combination of the above-mentioned "Pediococcus pentosaceus" and "Lactobacillus" lactobacilli can play a role in reducing the irritation of alcohol to the stomach, while relieving erosive gastritis, stomachache, and nausea. In addition, since the above-mentioned lactobacilli promote proliferation in the presence of dietary fiber, they show effects such as enhancing the healing effect of gastric ulcers when combined with cabbage powder.

[0059] In one embodiment, in the food composition, the content of L-ornithine is 15 to 30% by weight based on the total weight of the composition, the content of potassium citrate is 2 to 12% by weight based on the total weight of the composition, the content of cabbage powder is 30 to 50% by weight based on the total weight of the composition, and the content of lactobacilli is 2 to 14% by weight based on the total weight of the composition.

[0060] More specifically, based on the total weight of the composition, the content of L-ornithine is 15% by weight or more, 16% by weight or more, 17% by weight or more, 18% by weight or more, 19% by weight or more, 20% by weight or more, 21% by weight or more, 22% by weight or more, 23% by weight or more; its content is 30% by weight or less, 29% by weight or less, 28% by weight or less, 27% by weight or less, 26% by weight or less, 25% by weight or less, 24% by weight or less, 23% by weight or less.

[0061] In one embodiment, based on the total weight of the composition, the content of potassium citrate is 2 to 12% by weight. More specifically, based on the total weight of the composition, the content of potassium citrate is more than 2% by weight, more than 3% by weight, more than 4% by weight, more than 5% by weight, more than 6% by weight, more than 6.7% by weight; and its content is less than 12% by weight, less than 11% by weight, less than 10% by weight, less than 9% by weight, less than 8% by weight, less than 7% by weight, less than 6.7% by weight.

[0062] More specifically, the content of the cabbage powder is more than 30% by weight, more than 31% by weight, more than 32% by weight, more than 33% by weight, more than 34% by weight, more than 35% by weight, more than 36% by weight, more than 37% by weight, more than 38% by weight, more than 39% by weight, more than 40% by weight based on the total weight of the composition; and it is 50% by weight or less, 49% by weight or less, 48% by weight or less, 47% by weight or less, 46% by weight or less, 45% by weight or less, 44% by weight or less, 43% by weight or less, 42% by weight or less, 41% by weight or less, 40% by weight or less.

[0063] More specifically, based on the total weight of the composition, the content of the lactic acid bacteria is more than 2% by weight, more than 3% by weight, more than 4% by weight, more than 5% by weight, more than 6% by weight, more than 7% by weight; and the content is less than 14% by weight, less than 13% by weight, less than 12% by weight, less than 11% by weight, less than 10% by weight, less than 9% by weight, less than 8% by weight, less than 7% by weight, less than 6% by weight.

[0064] In one embodiment, in the food composition, the weight ratio of L-ornithine, potassium citrate, cabbage powder and lactic acid bacteria is 2 to 5: 1 to 2 to 2: 4 to 10: 1 to 2, or 3 to 4: 1 to 2: 5 to 8: 1 to 2, or 3 to 4: 1 to 2: 5 to 7: 1 to 2: 2.

[0065] In one embodiment, the food composition further comprises celery powder.

[0066] The "water celery powder" contains persicarin that activates enzymes related to alcohol metabolism. Water celery is a perennial herb of the Apiaceae family, growing throughout Korea, widely distributed in regions from Asia to the tropics such as China and Japan, and is cultivated for consumption.

[0067] The content of the water dropwort powder is 3 to 13% by weight of the total weight of the composition. More specifically, the content of the dropwort powder is more than 3% by weight, more than 4% by weight, more than 5% by weight, more than 6% by weight, more than 7% by weight, more than 8% by weight, more than 8.14% by weight of the total weight of the composition; its content is less than 13% by weight, less than 12% by weight, less than 11% by weight, less than 10% by weight, less than 9% by weight and less than 8.14% by weight.

[0068] In one embodiment, the food composition further comprises a turmeric extract.

[0069] The pharmacological effects of the above-mentioned "turmeric extract" include cholagogic effect, uterine excitatory effect, blood pressure lowering effect, analgesic effect, etc. It has the effect of inhibiting the growth of Staphylococcus aureus, fungi, etc., and has been proven to have the effect of reducing hyperlipidemia

Korean Compendium of Materia Medica, written by An Dejun

[0070] Based on the total weight of the composition, the content of the turmeric extract is 3 to 13% by weight. More specifically, the content of the turmeric extract is more than 3% by weight, more than 4% by weight, more than 5% by weight, more than 6% by weight, more than 7% by weight, more than 8% by weight of the total weight of the composition; its content is less than 13% by weight, less than 12% by weight, less than 11% by weight, less than 10% by weight, less than 9% by weight and less than 8% by weight.

[0071] According to an embodiment of the present invention, the composition is a health functional food composition. In one embodiment, the above food composition can be made into a health food in the form of powder, granule, pill, bolus, capsule or beverage. The manufacturing methods can be baking method and far-infrared method, but are not limited thereto.

[0072] The "health food" refers to a food prepared and processed by methods such as extraction, concentration, refining, mixing, etc. using specific ingredients as raw materials, or specific ingredients in the raw materials, and is designed and processed to fully exert biological regulatory functions such as biological defense on organisms through the above ingredients, and refers to a food that can exert functions related to preventing, improving diseases or restoring health.

[0073] There is no particular limitation on the types of health foods that can use the extract of the present invention. For example, dairy products, including ramen, other noodles, beverages, tea, drinks, alcoholic beverages, various soups, meats, sausages, bread, chocolate, candies, cookies, pizza, chewing gum, ice cream, or vitamin complexes. In addition, the health food includes powder, granule, pill, capsule or beverage form, preferably beverage form. In addition, when the extract according to the present invention is used as a health food, it can be added alone or used together with other foods or food ingredients, and can be selected and appropriately used as needed. In addition, in addition to the extract according to the present disclosure, appropriate other auxiliary ingredients and disclosed additives that are usually included in health functional foods can be mixed according to the selection of those skilled in the art.

[0074] Preparation method of food composition for hangover relief and liver function improvement

[0075] On the other hand, the present invention provides a method for preparing a food composition for relieving hangover and improving liver function, comprising: a step of mixing a powder raw material of lactic acid bacteria containing one or more selected from L-ornithine, potassium citrate, cabbage powder, and non-skin bacteria and Lactobacillus with water to prepare a mixture; a step of preparing a ring precursor by cyclizing the mixture; a step of shaping the spherical ring precursor into a smooth surface; and a step of manufacturing a ring by drying the ring precursor having a smooth surface.

[0076] In another aspect, the present invention provides a method for preparing a food composition for relieving hangover and improving liver function, comprising: a step of extracting and drying cabbage to prepare cabbage powder; and a step of mixing one or more lactic acid bacteria selected from L-ornithine, potassium citrate, and non-skin bacteria and Lactobacillus into the cabbage powder.

[0077] In the preparation method according to an embodiment of the present invention, the extraction may pulverize the freeze-dried raw material, then add distilled water, and extract at 75-85 °C for 2 to 4 hours. Preferably, distilled water is added to the freeze-dried raw material and extracted repeatedly 3 times at 80 °C for 3 hours each time.

[0078] According to an embodiment of the present invention, the step of preparing the powder may be performed before the mixing step, may be performed after the mixing step, or may be performed simultaneously.

[0079] In one embodiment, the powder raw material and water are mixed at a weight ratio of 1 to 3:1. More specifically, they are mixed at a weight ratio of 7:3.

[0080] In one embodiment, the diameter of the ring precursor is 4 to 6 mm. More specifically, it is 5 mm.

[0081] In one embodiment, it further includes the step of packing the ring in a four-sided packaging container in a square or rectangular shape.

[0082] In one embodiment, the drying is carried out at 35°C - 37°C for 60 to 72 hours.

[0083] In one embodiment, the preparation method includes: the step of mixing various powder raw materials; the step of putting the mixed raw materials and water into a blender for stirring; the step of putting the dough into a forming machine to form it into a ring shape; the step of putting the formed ring into a shaping machine to shape the surface of the ring; the step of putting the shaped ring into a dryer for drying; the step of putting the dried pills into a pill sorting machine to screen out defective pills; and the step of inner-packaging the screened pills in four-sided packaging paper; the step of moving the semi-finished product of the inner-packaging to a packaging room for individual boxing for factory shipment; and the step of moving the boxed finished product to the location for shipment.

[0084]

Embodiment

[0085] Hereinafter, the present invention will be described in detail through embodiments. However, the following embodiments are only examples to help understand the whole disclosure, and the content of the present disclosure is not limited to the following embodiments.

[0086] <Manufacturing Example 1> Manufacturing of food composition for hangover relief and liver function improvement

[0087] According to the compositions shown in Table 1 and Table 2 below, food compositions for relieving hangover and improving liver function according to Embodiments 1 to 4 of the present invention were prepared.

[0088]

Table 1

[0089]

[0090]

Table 2

[0091]

[0092]

Table 3

[0093]

[0094]

[0095]

Table 4

[0096]

[0097] <Reference Example 1> Preparation of composition according to comparative example

[0098] Except for not containing L-ornithine, not containing potassium citrate, not containing cabbage powder, and not containing lactic acid bacteria, the compositions according to Comparative Examples 1 to 4 were prepared in the same manner as in Example 1, respectively.

[0099] <Experimental Example 1> Evaluation of inhibition of increase in blood alcohol concentration

[0100] The subjects were aged 30 - 40 years old, weighed 65 - 75 kg, with 10 males and 10 females each, and the alcohol consumption was 400 ml (alcohol content 19.5%). The experiment measured the initial alcohol concentration 30 minutes after drinking, and then 5 g of the health foods prepared in the examples and comparative examples were consumed. The alcohol concentration (unit: mg / L) was measured with an alcohol tester 90 minutes after drinking. The differences in alcohol concentration 30 minutes after drinking and 90 minutes after drinking are shown in Table 5 below.

[0101]

Table 5

[0102]

[0103]

[0104] <Experimental Example 2> Assessment using Alcohol Hangover Severity Scale (AHSS)

[0105] The subjects were aged 30 - 50 years old, weighed 65 - 75 kg, with 10 males and 10 females each, and the alcohol consumption was 400 ml (alcohol content 19.5%). This experiment evaluated the symptoms before and after drinking (0 = none, 10 = extreme). The results are shown in Table 6 below (after taking: before taking).

[0106]

Table 6

[0107]

[0108]

[0109] As can be seen from Table 6, after taking the health food of the present invention, the severity of alcohol hangover has been improved.

[0110] <Formulation Example 1> Preparation of pills

[0111] Pills were prepared by a conventional method according to the composition shown in Table 7 below.

[0112]

Table 7

[0113]

[0114]

[0115] <Formulation Example 2> Preparation of pills Pills were prepared by a conventional method according to the composition shown in Table 8 below.

[0116]

Table 8

[0117]

[0118]

[0119] <Formulation Example 9> Preparation of pills

[0120] Prepare a health functional beverage by the conventional method according to the composition shown in Table 9 below.

[0121] [Table 9]

[0122]

[0123] Although the present invention has been described in connection with the above preferred embodiments, various modifications or variations can be made without departing from the gist and scope of the present invention. Therefore, the scope of the appended claims will cover these modifications or variations as long as they fall within the scope of the present invention.

Claims

1. A food composition for relieving a hangover and improving liver function, wherein, Lactic acid bacteria including one or more selected from L-ornithine, potassium citrate, cabbage powder, and non-pidotrichum and lactobacillus.

2. The food composition according to claim 1, wherein Based on the total weight of the composition, the content of L-ornithine is 15 to 30% by weight, Based on the total weight of the composition, the content of potassium citrate is 2 to 12% by weight, The content of the cabbage powder is 30 to 50% by weight of the total weight of the composition, Based on the total weight of the composition, the content of lactic acid bacteria is 2 to 12% by weight.

3. A method for preparing a food composition for relieving hangover and improving liver function, comprising: A step of mixing a powder raw material of lactic acid bacteria including one or more selected from L-ornithine, potassium citrate, cabbage powder, and non-pidotrichum and lactobacillus with water to prepare a mixture; A step of preparing a cyclic precursor by cyclizing the mixture; A step of shaping the cyclic precursor into a smooth surface; And A step of manufacturing a ring by drying the cyclic precursor having a smooth surface.

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