Preparation method and application of composition with sarcopenia resisting effect

Abstract

The invention relates to the technical field of pharmaceutical compositions, and particularly discloses a preparation method and application of a composition with an anti-sarcopenia effect, and the composition is prepared from radix astragali extract, rhizoma atractylodis macrocephalae extract, vitamin D and lecithin. According to the invention, the astragalus extract is used for enhancing the mitochondrial function, the bighead atractylodes rhizome extract is used for improving muscle nutrition, the vitamin D is used for promoting protein synthesis, and the lecithin is used for repairing cell membranes, so that the astragalus extract, the bighead atractylodes rhizome extract, the vitamin D and the lecithin cooperate to resist sarcopenia from energy metabolism and structure repair to function enhancement in multiple dimensions.

Description

Technical Field

[0001] The present invention belongs to the technical field of pharmaceutical compositions, and particularly relates to a preparation method and application of a composition with the efficacy of anti-sarcopenia. Background Art

[0002] Sarcopenia is a syndrome characterized by the progressive decline of skeletal muscle mass, strength, and function related to age, which seriously affects the quality of life and independent activity ability of the elderly. Its pathological mechanisms involve multiple factors such as mitochondrial dysfunction, reduced protein synthesis, increased oxidative stress, and decreased muscle cell membrane repair ability. Currently, the main intervention methods for sarcopenia include nutritional supplementation and resistance training, but there are problems such as poor compliance and limited effects.

[0003] In the prior art, skin care products mostly focus on moisturizing, anti-wrinkle, or antioxidant functions. Although some studies have attempted to use traditional Chinese medicine extracts for anti-aging, their mechanism of action leads to a single curative effect and it is difficult to comprehensively delay muscle aging. Summary of the Invention

[0004] The purpose of the present invention is to provide a preparation method and application of a composition with the efficacy of anti-sarcopenia to solve the problems raised in the above background art.

[0005] To achieve the above purpose, the present invention provides the following technical solutions:

[0006] A composition with the efficacy of anti-sarcopenia, comprising the following components in parts by weight:

[0007] 100 parts of astragalus extract, 60 parts of atractylodes macrocephala extract, 1 part of vitamin D, and 20 parts of lecithin.

[0008] Preferably, the astragalus extract is prepared by the following steps:

[0009] After washing, drying, and pulverizing raw astragalus, it is soaked in 8 times the volume of distilled water at room temperature for 4 hours, heated and steamed for 1 hour, and the extract is filtered; the steaming and extraction are repeated 3 times, the three extracts are combined, distilled and concentrated, then precipitated with ethanol, allowed to stand, and filtered to obtain an astragalus extract paste with a specific gravity of 1.2 - 1.25.

[0010] Preferably, the atractylodes macrocephala extract is prepared by the following steps:

[0011] After washing, drying, and pulverizing raw atractylodes macrocephala, it is soaked in 8 times the volume of distilled water at room temperature for 4 hours, heated and steamed for 1 hour, and the extract is filtered; the steaming and extraction are repeated 3 times, the three extracts are combined, distilled and concentrated, then precipitated with ethanol and evaporated to obtain an atractylodes macrocephala extract paste with a specific gravity of 1.2 - 1.25.

[0012] Preferably, the vitamin D is fat-soluble vitamin D.

[0013] A preparation method of a composition with anti-sarcopenia efficacy, comprising the following steps:

[0014] Weigh astragalus extract, atractylodes macrocephala extract, vitamin D and lecithin in proportion, and mix them evenly to form a compound composition.

[0015] Preferably, the compound composition is further used to prepare body lotion or body essential oil.

[0016] A body care product with anti-sarcopenia, comprising the composition described in any one of the above, and the body care product is body lotion or body essential oil.

[0017] Preferably, the mass percentage of the composition in the body lotion or body essential oil is 5%-30%.

[0018] Use of the composition described in any one of the above in the preparation of a medicament or health product for preventing or treating sarcopenia.

[0019] Compared with the prior art, the beneficial effects of the present invention are:

[0020] (1) By enhancing mitochondrial function with astragalus extract, improving muscle nutrition with atractylodes macrocephala extract, promoting protein synthesis with vitamin D, and repairing cell membranes with lecithin, the four work together to combat sarcopenia from multiple dimensions including energy metabolism, structural repair to functional enhancement.

[0021] (2) The components of the present invention are safe and non-toxic, can be made into external body lotion / essential oil, are convenient to use, integrate the theory of traditional Chinese medicine for invigorating qi and strengthening the spleen with modern nutrition, take into account "treating both the symptoms and the root causes", and have a simple preparation process and easily available raw materials. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a process flow chart of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0023] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0024] Example 1:

[0025] Please refer to Figure 1 as shown, a preparation method of a composition with anti-sarcopenia efficacy, comprising:

[0026] Preparation of Astragalus membranaceus extract: Take 1000 grams of raw Astragalus membranaceus, wash it, dry it to constant weight, crush it into coarse powder, add 8 times the volume of distilled water (8000 mL), soak it at room temperature for 4 hours, heat it to boiling, keep it boiling gently for 1 hour, filter to collect the extract, repeat the boiling extraction 3 times, combine the three extracts, concentrate the extract by reduced pressure distillation to 1 / 5 of the original volume, add 95% ethanol until the ethanol concentration is 70%, let it stand for 24 hours, filter to remove the precipitate, and continue to concentrate the filtrate to an extract with a specific gravity of 1.2 - 1.25, then the Astragalus membranaceus extract is obtained;

[0027] Preparation of Atractylodes macrocephala extract: Take 600 grams of raw Atractylodes macrocephala, wash it, dry it to constant weight, crush it into coarse powder, add 8 times the volume of distilled water (4800 mL), soak it at room temperature for 4 hours, heat it to boiling, keep it boiling gently for 1 hour, filter to collect the extract, repeat the boiling extraction 3 times, combine the three extracts, concentrate the extract by reduced pressure distillation to 1 / 5 of the original volume, add 95% ethanol until the ethanol concentration is 70%, let it stand for 24 hours, filter and then concentrate it to an extract with a specific gravity of 1.2 - 1.25, then the Atractylodes macrocephala extract is obtained;

[0028] Compound preparation of the composition: Weigh by weight: 100 grams of Astragalus membranaceus extract, 60 grams of Atractylodes macrocephala extract, 1 gram of fat-soluble vitamin D, and 20 grams of pharmaceutical-grade lecithin. Mix the above components under sterile conditions and stir evenly to obtain the compound composition for preventing sarcopenia.

[0029] Example 2: Preparation of body lotion for preventing sarcopenia

[0030] Preparation of the basic cream matrix: Take 10 grams of glyceryl stearate, 5 grams of glycerol, and 70 grams of distilled water, heat it to 75 °C and stir until completely dissolved, and cool it to 40 °C for standby;

[0031] Add the composition: Add 15 grams (accounting for 15% of the final product) of the compound composition prepared in Example 1 to the above cream matrix, add 2 grams of emulsifier (Tween - 80), stir with a homogenizer for 20 minutes until uniform, adjust the pH to 6.0 - 6.5, and fill it to obtain the body lotion for preventing sarcopenia.

[0032] Example 3: Preparation of body essential oil for preventing sarcopenia

[0033] Preparation of the base oil: Take 50 grams of jojoba oil, 30 grams of sweet almond oil, and 5 grams of vitamin E oil, and mix them evenly.

[0034] Add the composition: Add 10 grams (accounting for 10% of the final product) of the compound composition prepared in Example 1 to the base oil, add 2 grams of lavender essential oil (for flavoring), stir until completely dissolved, filter and divide it into portions to obtain the body essential oil for preventing sarcopenia.

[0035] Although embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A composition with anti-sarcopenia effect, characterized in that: The composition comprises the following components in parts by weight: 100 parts of astragalus extract, 60 parts of atractylodes macrocephala extract, 1 part of vitamin D, and 20 parts of lecithin.

2. The anti-sarcopenia composition according to claim 1, characterized in that: The astragalus extract is prepared by the following steps: Wash, dry and crush the raw Astragalus, soak it in 8 times the volume of distilled water at room temperature for 4 hours, heat and steam for 1 hour, and filter to obtain the extract; repeat the steaming and extraction 3 times, combine the three extracts, distill and concentrate, precipitate with ethanol, let stand and filter to obtain an Astragalus extract with a specific gravity of 1.2-1.

25.

3. The anti-sarcopenia composition according to claim 1, characterized in that: The Atractylodes macrocephala extract is prepared by the following steps: Wash, dry and crush the raw Atractylodes macrocephala, soak it in 8 times the volume of distilled water at room temperature for 4 hours, heat and steam for 1 hour, and filter to obtain the extract; repeat the steaming and extraction 3 times, combine the three extracts, distill and concentrate, and then evaporate through alcohol precipitation to obtain an Atractylodes macrocephala extract with a specific gravity of 1.2-1.

25.

4. The anti-sarcopenia composition according to claim 1, characterized in that: The vitamin D is fat-soluble vitamin D.

5. A method for preparing a composition having anti-sarcopenia efficacy, characterized in that: The following steps are involved: Astragalus extract, Atractylodes macrocephala extract, vitamin D and lecithin are weighed in proportion and mixed evenly to form a composite composition.

6. The method for preparing a composition with anti-sarcopenia efficacy according to claim 5, characterized in that: The compound composition is further used for preparing body lotion or body essential oil.

7. A body care product for combating sarcopenia, characterized in that: The body care product comprises the composition according to any one of claims 1 to 4, wherein the body care product is a body lotion or a body essential oil.

8. The body care product according to claim 7, characterized in that: The mass percentage of the composition in body lotion or body essential oil is 5%-30%.

9. Use of the composition according to any one of claims 1 to 4 in the preparation of medicines or health products for preventing or treating sarcopenia.

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