Tendon-dredging and bone-penetrating pyretic moxibustion health-care cream and preparation method thereof

Abstract

The invention discloses a tendon-dredging and bone-penetrating pyretic moxibustion health-care paste and a preparation method thereof. According to the preparation, 32 traditional Chinese medicines such as radix clematidis, flos carthami, frankincense and the like are in a specific proportion, a beewax-microcrystalline wax matrix is combined to form a microporous slow release system, and the synergistic infiltration promotion effect of turpentine and borneol is matched, so that the transdermal rate of tanshinone IIA is greater than or equal to 5.0 mu g / cm < 2 > / h. Animal experiments prove that the analgesic onset time is shortened by 50% compared with that of a traditional plaster, and the total clinical effective rate is 89.2%. The preparation process adopts gradient extraction and low-temperature emulsification technologies, and effectively retains the activity of volatile components. The product is suitable for conditioning sub-health states of bone joints such as neck-shoulder pain and lumbocrural pain.

Description

Technical Field

[0002] The present invention belongs to the technical field of traditional Chinese medicine external preparations, and particularly relates to a Tongjin Tougu health care plaster that realizes synergistic transdermal absorption and continuous heat moxibustion effect through a specific component combination and preparation process. Background Art

[0003] Existing plasters generally have the following defects:

[0004] 1. Low transdermal efficiency: The penetration rate of alkaloid components in traditional black plasters is less than 30%.

[0005] 2. Single function: Most commercially available products focus on a single function of analgesia or promoting blood circulation.

[0006] 3. Uncontrollable heat effect: There is a compatibility taboo between the heating material and the drug active ingredient. Summary of the Invention

[0007] Innovation Points of the Technical Solution

[0008] 1. Component Synergy System:

[0009] Penetration-enhancing group: Turpentine (lipid-soluble carrier) + Menthol-Borneol (opening the stratum corneum channel).

[0010] Heat effect group: Dry Ginger + Asarum produce a continuous heat of 42 - 45 °C for 6 - 8 hours.

[0011] Efficacy group: Frankincense-Myrobalan-Triple-Nine Ginseng form "three-stage pain relief" (rapid analgesia + medium-term anti-inflammatory + long-term repair).

[0012] 2. Process Innovation:

[0013] Gradient extraction: Alcohol extraction of rhizome and root parts retains saponins, and water extraction of leaf parts obtains polysaccharides.

[0014] Temperature-controlled emulsification: The matrix forms a honeycomb structure at 50 - 55 °C.

[0015] Experimental Verification

[0016] 1. Transdermal Kinetics:

[0017] Component Q24 (μg / cm 2 ) of the present invention Q24 of traditional plaster Promotion rate Tanshinone IIA 132.7 ± 9.1

[0018] Safflower Yellow Pigment 89.4 ± 7.8

[0019] 2. Analgesic Timeliness (adjuvant arthritis model in rats):

[0020] At 2 hours, the VAS reduction rate of the present invention was 34.2%, and that of the control was 18.7%, P < 0.01. At 24 hours, the VAS reduction rate of the present invention was 67.5%, and that of the control was 49.8%, P < 0.05 BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 is a process flow chart of a Tongjin Tougu Heat Moxibustion Health Care Paste DETAILED DESCRIPTION OF THE INVENTION

[0022] Example 1 (optimal ratio):

[0023] 12 parts of Clematis chinensis, 10 parts of safflower, 8 parts of frankincense, 8 parts of myrrh, 15 parts of Ligusticum wallichii, 12 parts of Zanthoxylum nitidum, 20 parts of Spatholobus suberectus, 18 parts of Tinospora sinensis, 8 parts of turpentine, 12 parts of Epimedium brevicornu, 20 parts of Speranskia tuberculata, 15 parts of Phellodendron amurense, 10 parts of dried ginger, 12 parts of Herba Geranii, 15 parts of Angelica pubescens, 12 parts of Angelica sinensis, 18 parts of Acanthopanax gracilistylus, 15 parts of Achyranthes bidentata, 12 parts of Dipsacus asperoides, 25 parts of Salvia miltiorrhiza, 30 parts of Astragalus membranaceus, 25 parts of Pueraria lobata, 12 parts of Saposhnikovia divaricata, 6 parts of Asarum sieboldii, 10 parts of Acorus tatarinowii, 1.2 parts of menthol, 1.5 parts of borneol, 12 parts of Curcuma zedoaria, 10 parts of Psoralea corylifolia, 10 parts of Panax notoginseng. Key preparation parameters:

[0024] Alcohol extraction temperature: 62 ± 2°C, vacuum concentration pressure: -0.08 MPa

[0025] Homogenization speed: 2000 rpm, emulsification time: 22 minutes

[0026] Quality inspection:

[0027] 1. TLC identification:

[0028] For Salvia miltiorrhiza: Using tanshinone IIA as the reference substance, silica gel G plate, developing solvent: petroleum ether - ethyl acetate (8:2)

[0029] Spot Rf value: 0.35 ± 0.02 (examined under 365 nm ultraviolet light)

[0030] 2. Content determination:

[0031] Determination of safflower yellow pigment by HPLC method ≥ 1.2 mg / g (chromatographic conditions: C18 column, gradient elution with acetonitrile - 0.1% phosphoric acid)

Claims

1. A muscle-opening and bone-penetrating hot moxibustion health-care ointment, characterized in that Made from the following raw materials in parts by weight: 5-15 parts of clematis, 8-12 parts of safflower, 6-10 parts of frankincense, 6-10 parts of myrrh, 10-15 parts of chuanxiong, 8-12 parts of lianmianzhen, 15-20 parts of millettia, 10-18 parts of kudzuvine, 3-8 parts of turpentine, 5-12 parts of epimedium, 10-20 parts of radix schoenopraeviae, 8-15 parts of phellodendron, 5-10 parts of dried ginger, 6-12 parts of crane grass, 10-15 parts of angelica, 8-12 parts of acanthopanax bark, 10 -18 parts, Achyranthes bidentata 10-15 parts, Dipsacus asper 8-12 parts, Salvia miltiorrhiza 15-25 parts, Astragalus 20-30 parts, Pueraria lobata 15-25 parts, Saposhnikovia divaricata 8-12 parts, Asarum 3-6 parts, Acorus calamus 5-10 parts, menthol 0.5-1.2 parts, borneol 0.8-1.5 parts, Curcuma 8-12 parts, Psoralea corylifolia 6-10 parts, Panax notoginseng 5-10 parts, the matrix is ​​a mixture of beeswax and microcrystalline wax in the ratio of (2-4): 1; The health cream meets the following technical indicators: The transdermal rate of Tanshinone IIA is ≥5.0 μ g / cm 2 / h (Franz diffusion cell method, 32°C) Hot plate method pain threshold increase rate ≥ 120% (0.5g dose, 60min) The median onset time for clinical pain relief was ≤40 minutes.

2. The health cream according to claim 1, characterized in that: The melting temperature of the beeswax and microcrystalline wax in the matrix is ​​65-70° C., and after cooling, a microporous structure with a porosity of 15-20% is formed.

3. The health cream according to claim 1, characterized in that: The volatile components (menthol + borneol) account for 0.8-1.5% of the total weight and form a co-permeation-promoting system with turpentine oil, and the permeation-promoting factor PE value is 4.2-5.

6.

4. A method for preparing the health cream according to claim 1, characterized in that The following steps are involved: (1) Raw material pretreatment: Soak rhizomes of Achyranthes bidentata and Dipsacus asper in 40% ethanol for 2 hours and then slice them. The volatile components (menthol, borneol) are stored separately and sealed. (2) Step-by-step extraction: Water extraction group (15 herbs including Astragalus and Millettia reticulata): decocted twice (the first time with 8 times the amount of water, extracted at 90℃ for 2h, and the second time with 6 times the amount of water, extracted for 1.5h). Alcohol extraction group (8 herbs including Salvia miltiorrhiza and Psoralea corylifolia): 60% ethanol reflux extraction for 3 times (1.5 h each time). (3) Directed concentration: The extracts were combined and concentrated under reduced pressure to a relative density of 1.28-1.32 (measured at 60°C). Add beeswax-microcrystalline wax base and homogenize and emulsify at 50-55°C for 20 minutes. (4) Post-processing: When the temperature drops to 45°C, add the volatile ingredients and stir until the solidification point before filling.

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