Filtering device for hepatitis B virus in blood

Abstract

The invention relates to the technical field of blood filtration, in particular to a filtering device for hepatitis B virus in blood, which comprises a main body shell, a first empty slot is formed in the end part of the main body shell, a fixed shell is arranged in the first empty slot in a matched manner, and an enrichment adsorption mechanism is arranged on the inner side of the fixed shell; the enrichment adsorption mechanism comprises a placement groove formed in the end surface of the main body shell, a motor is fixedly connected to the main body shell in the placement groove, a third through hole is formed in the lower end of the fixed shell in a penetrating manner, a fixed rod is arranged at the transmission shaft end of the motor in the third through hole, and a matching ring is fixedly connected to the inner side surface of the fixed shell. The liquid in the third empty groove is pushed upwards, so that the pushed liquid passes through the aperture of the filtering membrane, blocked impurities are pushed out, the filtering efficiency is improved, meanwhile, the pushed liquid can drive hepatitis B viruses above the filtering membrane to move into the second empty groove, and the adsorption speed of the adsorption column is further increased.

Description

Technical Field

[0001] The present invention relates to the technical field of blood filtration, and particularly to a filtration device for hepatitis B virus in blood. Background Art

[0002] In bioengineering, filtering hepatitis B virus in blood is an important means to ensure blood transfusion safety and prevent the spread of hepatitis B virus. Hemodialysis is based on the principle of a semipermeable membrane. The patient's blood is drawn out of the body and passed through the semipermeable membrane of a dialyzer to remove metabolic wastes (such as urea, creatinine, etc.) in the blood and supplement necessary substances at the same time. For patients with hepatitis B virus in their blood, during dialysis, hepatitis B virus (HBV) is a DNA virus with a diameter of about 42 nanometers. This size exceeds the range of substances that can be filtered by a conventional hemodialysis semipermeable membrane. The pore size of the semipermeable membrane used in hemodialysis is usually small. Therefore, patients with hepatitis B virus in their blood need to filter the hepatitis B virus with a larger diameter in the blood before dialysis, and then perform dialysis on the blood to ensure that the blood after dialysis is completely clean. When transfusing blood, in order to improve the utilization rate of blood, for blood containing hepatitis B virus, it can be used normally after complete filtration treatment.

[0003] There are mainly two methods for removing hepatitis B virus from blood, namely immunoadsorption technology and membrane filtration technology. When treating with membrane filtration technology, the blood is treated with filtration membranes of multiple pore sizes, that is, substances with a diameter larger than that of hepatitis B virus are filtered out through a large-pore filtration membrane, and then the hepatitis B virus is filtered out through a small-pore filtration membrane, and then the filtered blood is mixed with the impurities filtered out by the large-pore filtration membrane before. The operation is very cumbersome. Immunoadsorption technology utilizes the principle of specific binding of antigen-antibody. Antibodies that can specifically bind to hepatitis B virus are fixed on the adsorption material. The adsorption column may adsorb other antigens when adsorbing hepatitis B virus. For blood with a low content of hepatitis B virus, the adsorption effect of the adsorption column is low. Summary of the Invention

[0004] The purpose of the present invention is to propose a filtration device for hepatitis B virus in blood to solve the drawbacks existing in the background art.

[0005] To achieve the above object, the technical solution adopted by the present invention is as follows: a filtering device for hepatitis B virus in blood, including a main body shell. A first empty slot is opened at the end of the main body shell. A fixed shell is arranged in cooperation in the first empty slot. An enrichment adsorption mechanism is arranged inside the fixed shell. The enrichment adsorption mechanism includes a placement slot opened on the end face of the main body shell. A motor is fixedly connected in the placement slot of the main body shell. A third through hole is penetrated and opened at the lower end of the fixed shell. A fixed rod is arranged at the end of the transmission shaft of the motor in the third through hole. A cooperation ring is fixedly connected to the inner side face of the fixed shell. A filter membrane is connected to the inner side of the cooperation ring. The inner side of the filter membrane is closely attached to the side face of the fixed rod. A collection mechanism is arranged at one end of the main body shell, and a feeding mechanism is arranged at the other end of the main body shell.

[0006] Preferably, a first fixing body is fixedly connected to the side face of the fixed rod above the filter membrane by bolts. A second empty slot is opened at the lower end of the first fixing body. An adsorption column is fixedly connected in the second empty slot. An annular track is fixedly connected to the upper end of the cooperation ring.

[0007] Preferably, a connecting rod is rotatably connected to the end face of the first fixing body. A roller is fixedly connected to the end of the connecting rod. The side face of the roller is closely attached to the annular track. A first gear is connected in the second empty slot. The end of the first gear is fixedly connected to the connecting rod. A second gear is rotatably connected in the second empty slot of the first fixing body. The second gear is meshed with the first gear. Brushes are fixedly connected to the ends of the second gear and the first gear respectively.

[0008] Preferably, a second fixing body corresponding to the position of the first fixing body is fixedly connected to the side face of the fixed rod below the filter membrane. An annular limiting slot is opened at the upper end of the second fixing body. A flexible ring is fixedly connected in the limiting slot of the second fixing body.

[0009] Preferably, a third empty slot is opened at the upper end of the second fixing body. A plurality of equally spaced electric telescopic rods are fixedly connected in the third empty slot of the second fixing body. The telescopic ends of several electric telescopic rods are fixedly connected to a guide plate slidably matched with the third empty slot. A plurality of second through holes are penetrated and opened at the lower end of the second fixing body. A one-way valve is penetrated and arranged at the end of the guide plate. A first cavity is opened at the upper end of the fixed rod. The lower end of the first cavity is communicated with the first empty slot. A solenoid valve is fixedly connected in the first cavity.

[0010] Preferably, a square cooperation slot is opened at the telescopic end of the motor. A limiting block is slidably matched in the cooperation slot. A rotating slot is opened at a position of the enrichment adsorption mechanism close to the fixed rod. A rotating plate is rotatably connected in the rotating slot. The lower end of the rotating plate is fixedly connected to the upper end of the limiting block. The upper end of the rotating plate is fixedly connected to the lower end of the fixed rod.

[0011] Preferably, the collecting mechanism includes a second cavity opened at the end of the main body shell. A plurality of first through holes are penetrated and opened at the lower ends of the main body shell and the fixed shell. A first connecting plate is fixedly connected in the second cavity of the main body shell by bolts. A first transfer ring is fixedly connected to the inner side of the first connecting plate. A liquid outlet pipe is fixedly connected to the inner side of the first transfer ring.

[0012] Preferably, the feeding mechanism includes a plurality of limiting rings opened at the end of the fixed shell. A limiting column is slidably connected in each of the plurality of limiting rings. A protection plate is fixedly connected to the ends of the plurality of limiting columns. A second transfer ring is fixedly connected to the inner side of the protection plate. A liquid inlet pipe is fixedly connected to the inner side of the second transfer ring.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] 1. The motor drives the limiting block to rotate, the limiting block drives the rotating plate to rotate, and the rotating plate drives the first fixing body and the second fixing body to rotate through the fixing rod. At this time, the device is placed with the collecting mechanism facing downwards. At this time, under the action of gravity, blood passes through the filter membrane, and hepatitis B virus and substances with a radius larger than that of the hepatitis B virus can be collected on the filter membrane. At this time, the content of hepatitis B virus in the area above the filter membrane in the fixed shell is relatively high. The fixing rod drives the adsorption column in the first fixing body to rotate, so that the hepatitis B virus above the filter membrane can be adsorbed and removed. Since the content of hepatitis B virus is relatively high, the efficiency of the device for adsorbing hepatitis B virus can be improved;

[0015] 2. When the guide plate moves upward, the liquid in the third empty groove can be pushed upward, so that the pushed liquid passes through the pore diameter of the filter membrane, and the blocked impurities are pushed out, improving the filtering efficiency. At the same time, the pushed liquid can drive the hepatitis B virus above the filter membrane to move into the second empty groove, thereby further accelerating the adsorption speed of the adsorption column. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a schematic diagram of the overall structure of the present invention;

[0017] Figure 2 is a cross-section of the whole of the present invention Figure 1 ;

[0018] Figure 3 is a cross-section of the whole of the present invention Figure 2 ;

[0019] Figure 4 is a schematic diagram of a partial structure of the present invention;

[0020] Figure 5 is the present invention Figure 2 enlarged view of part A;

[0021] Figure 6 For the present invention Figure 3 an enlarged view of part B;

[0022] Figure 7 For the present invention Figure 3 an enlarged view of part C;

[0023] Figure 8 For the present invention Figure 3 an enlarged view of part D;

[0024] Figure 9 For the present invention Figure 4 an enlarged view of part E.

[0025] 1. Main body shell; 2. Collection mechanism; 3. Feeding mechanism; 4. Enrichment adsorption mechanism; 5. First cavity; 6. Solenoid valve; 11. First empty slot; 12. Fixed shell; 13. Third through hole; 21. First through hole; 22. Liquid outlet pipe; 23. Second cavity; 24. First connecting plate; 25. First adapter ring; 31. Protection plate; 32. Liquid inlet pipe; 33. Second adapter ring; 34. Limit ring; 35. Limit post; 41. Placing groove; 42. Filter membrane; 43. Fixed rod; 44. First fixing body; 45. Annular track; 46. Roller; 47. Connecting rod; 48. First gear; 49. Brush; 410. Adsorption column; 411. Second empty slot; 412. Fitting ring; 413. Second fixing body; 414. Limit slot; 415. Flexible ring; 416. Third empty slot; 417. Guide plate; 418. Electric telescopic rod; 420. Check valve; 421. Second through hole; 422. Rotating slot; 423. Rotating plate; 424. Limit block; 425. Fitting groove; 426. Motor; 427. Second gear. Detailed implementation manners

[0026] The following description is used to disclose the present invention so that those skilled in the art can implement the present invention. The preferred embodiments in the following description are only examples, and those skilled in the art can think of other obvious variations.

[0027] Please refer to Figure 1 - Figure 9 , a filtering device for hepatitis B virus in blood, including a main body shell 1, wherein a first empty slot 11 is opened at an end of the main body shell 1, a fixed shell 12 is cooperatively arranged in the first empty slot 11, and an enrichment adsorption mechanism 4 is arranged inside the fixed shell 12.

[0028] In this embodiment, the enrichment adsorption mechanism 4 includes a placement groove 41 formed on the end face of the main body shell 1. A motor 426 is fixedly connected in the placement groove 41 of the main body shell 1. A third through hole 13 is formed through the lower end of the fixed shell 12. A fixed rod 43 is arranged in the third through hole 13 at the transmission shaft end of the motor 426. A matching ring 412 is fixedly connected to the inner side surface of the fixed shell 12. A filter membrane 42 is connected to the inner side of the matching ring 412. The inner side of the filter membrane 42 is closely attached to the side surface of the fixed rod 43.

[0029] A first fixing body 44 is fixedly connected to the side surface of the fixed rod 43 above the filter membrane 42 by bolts. A second empty groove 411 is formed at the lower end of the first fixing body 44. An adsorption column 410 is fixedly connected in the second empty groove 411. An annular track 45 is fixedly connected to the upper end of the matching ring 412.

[0030] A connecting rod 47 is rotatably connected to the end face of the first fixing body 44. A roller 46 is fixedly connected to the end of the connecting rod 47. The side surface of the roller 46 is closely attached to the annular track 45. A first gear 48 is connected in the second empty groove 411. The end of the first gear 48 is fixedly connected to the connecting rod 47. A second gear 427 is rotatably connected in the second empty groove 411 of the first fixing body 44. The second gear 427 is engaged with the first gear 48. Brushes 49 are respectively fixedly connected to the ends of the second gear 427 and the first gear 48.

[0031] A second fixing body 413 corresponding to the position of the first fixing body 44 is fixedly connected to the side surface of the fixed rod 43 below the filter membrane 42. An annular limiting groove 414 is formed at the upper end of the second fixing body 413. A flexible ring 415 is fixedly connected in the limiting groove 414 of the second fixing body 413.

[0032] A third empty groove 416 is formed at the upper end of the second fixing body 413. A plurality of equally spaced electric telescopic rods 418 are fixedly connected in the third empty groove 416 of the second fixing body 413. The telescopic ends of several electric telescopic rods 418 are fixedly connected to a guide plate 417 that is slidably matched with the third empty groove 416. A plurality of second through holes 421 are formed through the lower end of the second fixing body 413. A one-way valve 420 is arranged through the end of the guide plate 417. A first cavity 5 is formed at the upper end of the fixed rod 43. The lower end of the first cavity 5 is communicated with the first empty groove 11. A solenoid valve 6 is fixedly connected in the first cavity 5.

[0033] The telescopic end of the motor 426 is provided with a square fitting groove 425. A limiting block 424 is slidably fitted in the fitting groove 425. The enrichment adsorption mechanism 4 is provided with a rotating groove 422 near the fixed rod 43. A rotating plate 423 is rotatably connected in the rotating groove 422. The lower end of the rotating plate 423 is fixedly connected to the upper end of the limiting block 424, and the upper end of the rotating plate 423 is fixedly connected to the lower end of the fixed rod 43.

[0034] Specifically, under the action of gravity, blood passes through the filter membrane 42, and hepatitis B virus and substances with a radius larger than that of the hepatitis B virus can be collected on the filter membrane 42. At this time, the hepatitis B virus content in the area above the filter membrane 42 in the fixed shell 12 is relatively high. The fixed rod 43 drives the adsorption column 410 in the first fixing body 44 to rotate, so that the hepatitis B virus above the filter membrane 42 can be adsorbed and removed. Since the hepatitis B virus content is relatively high, the adsorption efficiency of the device for hepatitis B virus can be improved.

[0035] In this embodiment, a collection mechanism 2 is provided at one end of the main body shell 1.

[0036] The collection mechanism 2 includes a second cavity 23 opened at the end of the main body shell 1. A plurality of first through holes 21 are formed through the lower ends of the main body shell 1 and the fixed shell 12. The main body shell 1 is fixedly connected to a first connecting plate 24 by bolts in the second cavity 23. The inner side of the first connecting plate 24 is fixedly connected to a first adapter ring 25, and the inner side of the first adapter ring 25 is fixedly connected to a liquid outlet pipe 22.

[0037] Specifically, when the electromagnetic valve 6 is started, the liquid outlet pipe 22 is loosened at the same time, so that the final blood enters the second cavity 23 through the first cavity 5 and is finally discharged through the liquid outlet pipe 22, which can ensure that only the hepatitis B virus in the blood is removed by this device.

[0038] In this embodiment, a feeding mechanism 3 is provided at the other end of the main body shell 1.

[0039] The feeding mechanism 3 includes a plurality of limiting rings 34 opened at the end of the fixed shell 12. A plurality of limiting columns 35 are respectively slidably connected in the limiting rings 34. The ends of the plurality of limiting columns 35 are fixedly connected to a protection plate 31. The inner side of the protection plate 31 is fixedly connected to a second adapter ring 33, and the inner side of the second adapter ring 33 is fixedly connected to a liquid inlet pipe 32.

[0040] Specifically, the protection plate 31 is placed according to the sliding fit between the limiting columns 35 and the limiting rings 34, and then the protection plate 31 and the main body shell 1 are fixed by bolts. At this time, the blood to be filtered is continuously introduced into the first empty groove 11 through the liquid inlet pipe 32.

[0041] During use, first completely disinfect the parts in this device. Then place the fixed shell 12 in the first empty slot 11, and at the same time ensure that the limiting block 424 at the lower end of the rotating plate 423 in the fixed shell 12 is in sliding fit with the mating groove 425 at the telescopic end of the motor 426. Then place the protective plate 31 according to the sliding fit between the limiting posts 35 and the limiting ring 34, and then fix the protective plate 31 and the main body shell 1 with bolts. At this time, continuously introduce the blood to be filtered into the first empty slot 11 through the liquid inlet pipe 32. Then start the motor 426. The motor 426 drives the limiting block 424 to rotate, the limiting block 424 drives the rotating plate 423 to rotate, and the rotating plate 423 drives the first fixing body 44 and the second fixing body 413 to rotate through the fixing rod 43. At this time, place the device with the collecting mechanism 2 facing downwards. At this time, under the action of gravity, the blood passes through the filter membrane 42, and hepatitis B virus and substances with a radius larger than that of the hepatitis B virus can be collected on the filter membrane 42. At this time, the content of hepatitis B virus in the area above the filter membrane 42 in the fixed shell 12 is relatively high. The fixing rod 43 drives the adsorption column 410 in the first fixing body 44 to rotate, so as to adsorb and remove the hepatitis B virus above the filter membrane 42. Since the content of hepatitis B virus is relatively high, the adsorption efficiency of the device for hepatitis B virus can be improved.

[0042] At this time, the first fixing body 44 drives the roller 46 to rotate along the annular track 45 through the connecting rod 47. At this time, the first gear 48 and the second gear 427 in the first fixing body 44 rotate under the drive of the connecting rod 47, and the first gear 48 and the second gear 427 drive the brush 49 to rotate in the reverse direction, so as to drive the substances below the first fixing body 44 into the second empty slot 411, which can accelerate the contact speed between the hepatitis B virus in the blood and the adsorption column 410, thereby improving the adsorption efficiency. At this time, the electric telescopic rod 418 in the second fixing body 413 continuously reciprocates and stretches. The telescopic end of the electric telescopic rod 418 drives the guide plate 417 to move along the third empty slot 416. When the guide plate 417 moves upward, it can push the liquid in the third empty slot 416 upward, so that the pushed liquid passes through the pore diameter of the filter membrane 42 to push out the blocked impurities, improving the filtering efficiency. At the same time, the pushed liquid can drive the hepatitis B virus above the filter membrane 42 to move into the second empty slot 411, thereby further accelerating the adsorption speed of the adsorption column 410. The main body shell 1 and the fixed shell 12 are made of transparent materials. When a batch of blood to be filtered is almost purified, at this time, squeeze and seal the liquid outlet pipe 22, so that the hepatitis B virus in the blood in the fixed shell 12 is completely adsorbed by the adsorption column 410 under the action of gravity. After adsorption for a period of time, start the solenoid valve 6 and at the same time loosen the liquid outlet pipe 22. Finally, the purified blood drives the substances with a radius larger than that of the hepatitis B virus to enter the second cavity 23 through the first cavity 5, and finally is discharged through the liquid outlet pipe 22, which can ensure that this device only removes the hepatitis B virus in the blood and keeps other components in the blood unchanged after removal.

[0043] The foregoing has shown and described the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments, and what is described in the above embodiments and the specification is only the principle of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of protection required by the present invention is defined by the appended claims and their equivalents.

Claims

1. A device for filtering hepatitis B virus in blood, comprising a main body shell (1), characterized in that: The end of the main shell (1) is provided with a first empty groove (11), a fixed shell (12) is arranged in the first empty groove (11), an enrichment adsorption mechanism (4) is arranged on the inner side of the fixed shell (12), the enrichment adsorption mechanism (4) comprises a placement groove (41) provided on the end surface of the main shell (1), the main shell (1) is fixedly connected with a motor (426) in the placement groove (41), and a third through hole (13) is penetrated through the lower end of the fixed shell (12). A fixed rod (43) is arranged at the transmission shaft end of the motor (426) in the third through hole (13); a matching ring (412) is fixedly connected to the inner side of the fixed shell (12); a filter membrane (42) is connected to the inner side of the matching ring (412); the inner side of the filter membrane (42) is tightly fitted with the side of the fixed rod (43); a collecting mechanism (2) is arranged at one end of the main shell (1); and a feeding mechanism (3) is arranged at the other end of the main shell (1).

2. The filtering device for hepatitis B virus in blood according to claim 1, characterized in that: The side surface of the fixing rod (43) is fixedly connected to a first fixing body (44) above the filter membrane (42) by means of bolts, a second empty groove (411) is provided at the lower end of the first fixing body (44), an adsorption column (410) is fixedly connected in the second empty groove (411), and an annular ring track (45) is fixedly connected to the upper end of the matching ring (412).

3. The filtering device for hepatitis B virus in blood according to claim 2, characterized in that: The end surface of the first fixed body (44) is rotatably connected to a connecting rod (47), the end of the connecting rod (47) is fixedly connected to a roller (46), the side of the roller (46) is arranged in close contact with the annular track (45), the second empty groove (411) is connected to a first gear (48), the end of the first gear (48) is fixedly connected to the connecting rod (47), the first fixed body (44) is rotatably connected to a second gear (427) in the second empty groove (411), the second gear (427) is meshed with the first gear (48), and the ends of the second gear (427) and the first gear (48) are respectively fixedly connected to brushes (49).

4. The filtering device for hepatitis B virus in blood according to claim 2, characterized in that: A second fixing body (413) corresponding to the position of the first fixing body (44) is fixedly connected to the side of the fixing rod (43) below the filter membrane (42); an annular limiting groove (414) is provided at the upper end of the second fixing body (413); and a flexible ring (415) is fixedly connected to the second fixing body (413) in the limiting groove (414).

5. The filtering device for hepatitis B virus in blood according to claim 4, characterized in that: A third slot (416) is provided at the upper end of the second fixed body (413); a plurality of equally spaced electric telescopic rods (418) are fixedly connected to the second fixed body (413) in the third slot (416); the telescopic ends of a plurality of the electric telescopic rods (418) are fixedly connected to guide plates (417) that are slidably matched with the third slot (416); a plurality of second through holes (421) are penetrated through the lower end of the second fixed body (413); a one-way valve (420) is penetrated through the end of the guide plate (417); a first cavity (5) is provided at the upper end of the fixed rod (43); the lower end of the first cavity (5) is communicated with the first slot (11); and a solenoid valve (6) is fixedly connected to the first cavity (5).

6. The filtering device for hepatitis B virus in blood according to claim 1, characterized in that: The telescopic end of the motor (426) is provided with a square matching groove (425), and a limit block (424) is slidably matched in the matching groove (425). The enrichment and adsorption mechanism (4) is provided with a rotating groove (422) at a position close to the fixed rod (43), and a rotating plate (423) is rotatably connected in the rotating groove (422). The lower end of the rotating plate (423) is fixedly connected to the upper end of the limit block (424), and the upper end of the rotating plate (423) is fixedly connected to the lower end of the fixed rod (43).

7. The filtering device for hepatitis B virus in blood according to claim 1, characterized in that: The collecting mechanism (2) comprises a second cavity (23) opened at the end of the main shell (1); a plurality of first through holes (21) are penetrated through the lower ends of the main shell (1) and the fixed shell (12); the main shell (1) is fixedly connected to a first connecting plate (24) in the second cavity (23) by bolts; a first adapter ring (25) is fixedly connected to the inner side of the first connecting plate (24); and a liquid outlet pipe (22) is fixedly connected to the inner side of the first adapter ring (25).

8. The filtering device for hepatitis B virus in blood according to claim 1, characterized in that: The feeding mechanism (3) comprises a plurality of limiting rings (34) opened at the end of the fixed shell (12), the limiting pillars (35) are slidably connected in the plurality of limiting rings (34), the ends of the plurality of limiting pillars (35) are fixedly connected with a protective plate (31), the inner side of the protective plate (31) is fixedly connected with a second adapter ring (33), and the inner side of the second adapter ring (33) is fixedly connected with a liquid inlet pipe (32).

Images