Fixing and locking assembly and fixing device of kit

Abstract

The invention provides a fixing and locking assembly which is used for locking and fixing a kit placed on a base and comprises a positioning part, a connecting rod, a rotary fixing part and a pushing part, one end of the connecting rod is rotationally connected with the pushing part, and the other end of the connecting rod is rotationally connected with the rotary fixing part; the positioning part is fixed on the base; the rotary fixing part sleeves the positioning part and can be driven by the connecting rod to rotate on the positioning part; when the pushing part pushes the connecting rod, the connecting rod drives the rotary fixing part to rotate to a proper position to be separated from the kit, and when the pushing part drives the connecting rod to reset, the connecting rod drives the rotary fixing part to rotate to a proper position to abut against the kit. The invention also provides a fixing device and purification equipment. According to the kit locking device, the kit can be fixed and locked without being pressed down by a large force, and the situation that the kit is displaced or even taken up in the purification working process is avoided.

Description

Technical Field

[0001] The present invention relates to the field of limiting a kit, and particularly to a fixing and locking assembly and a fixing device for a kit. Background Art

[0002] At present, the magnetic bead purification method based on magnetic particles not only meets the high-quality requirements of scientific researchers for target biomolecules such as nucleic acids and proteins, but also improves the work efficiency of scientific researchers with its characteristics of automation, high throughput, high speed, and high sensitivity.

[0003] In existing magnetic bead purification equipment, there is a phenomenon that the kit moves or even deviates from its original set position during the working process. In actual use, there is still an unstable positioning problem of the kit. During the purification process, the kit may be lifted because it cannot be positioned. Moreover, the kit is often fixed by clamping, which makes it inconvenient to place and take the kit during use.

[0004] Therefore, it is urgent to solve the above technical problems. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a fixing and locking assembly and a fixing device for a kit, which can realize the fixing and locking of the kit without the need to press down forcefully, ensure that the kit does not move or even be lifted during the purification process, and is convenient to use.

[0006] To this end, a fixing and locking assembly provided by the present invention is used to lock and fix a kit placed on a base, and includes: a positioning part, a connecting rod, a rotary fixing part, and a pushing part. One end of the connecting rod is rotatably connected to the pushing part, and the other end is rotatably connected to the rotary fixing part; the positioning part is used to be fixed on the base; the rotary fixing part is sleeved on the positioning part and can be driven by the connecting rod to rotate on the positioning part; the pushing part is used to push the connecting rod to drive the rotary fixing part:

[0007] When the pushing part pushes the connecting rod, the connecting rod drives the rotary fixing part to rotate to an appropriate position to separate from the kit.

[0008] When the pushing part drives the connecting rod to reset, the connecting rod drives the rotary fixing part to rotate to an appropriate position to abut against the kit.

[0009] Specifically, the pushing part has a pushing member and an elastic member. When the pushing is performed, the pushing member is pushed and the elastic member is compressed. When the pushing is cancelled, the pushing member drives the connecting rod to perform the reset under the elastic rebound of the elastic member. Preferably, the elastic member is a spring. More preferably, the pushing member is a push rod, and the spring is sleeved on the push rod. Further preferably, the push rod and the connecting rod are rotatably connected by a pin.

[0010] Specifically, the rotating and fixing part is sleeved on the positioning part through a bearing. Preferably, the bearing is a double-row bearing.

[0011] Specifically, the fixing and locking assembly further includes: a limiting main body fixed on the base. A through hole is provided on the limiting main body. One end of the push rod extends out from the first opening of the through hole and is rotatably connected to the connecting rod. The other end of the push rod remains outside the second opening of the through hole. The spring is limited in the through hole to be compressed or rebound.

[0012] Preferably, the limiting main body is provided with a first limiting structure and / or a second limiting structure:

[0013] The first limiting structure is used to limit the moving distance of the push rod during the reset. Further preferably, the first limiting structure is arranged as follows: there is a protrusion below the first opening, and a limiting groove is provided on the protrusion. The limiting groove is used to limit the pin to limit the moving distance.

[0014] The second limiting structure is used to limit the rotation angle of the rotating and fixing part when the pushing is performed. Further, the limiting structure is a limiting block arranged on the limiting main body, which is used to limit the position of the connecting rod when it is pushed to limit the rotation angle.

[0015] Specifically, the limiting main body is provided with an opening groove facing the base. The opening groove has two front and rear inner walls and a top wall connecting the two inner walls. The through hole penetrates the rear inner side wall of the opening groove from one end of the limiting main body close to the push rod. The first limiting structure is arranged on the rear inner wall, and the second limiting structure is arranged on a part near the front inner wall of the opening groove. The positioning part is arranged in the opening of the groove. The rotating and fixing part has at least one abutting part. When the rotating and fixing part is pushed, the abutting part is separated from the kit and is located in the opening groove. When the connecting rod is reset, the abutting part extends out of the opening groove and abuts against the kit. Preferably, the overall shape of the limiting main body is a cuboid.

[0016] Specifically, the rotation fixing part has two symmetric abutting parts in its length direction, and the two abutting parts respectively correspond to two of the reagent kits arranged side by side.

[0017] When the rotation fixing part is pushed, the two abutting parts are separated from the adjacent reagent kits respectively and are located in the opening groove. Further, the straight line connecting the centers of the two abutting parts is parallel to the length direction of the top wall. When the connecting rod resets, the two abutting parts abut against the adjacent reagent kits respectively and are located outside the opening groove. Further, the straight line connecting the centers of the two abutting parts is perpendicular to the length direction of the top wall.

[0018] More preferably, the opening groove is rectangular. Further, the overall width of the rotation fixing part is less than or equal to the width of the top wall.

[0019] Specifically, a button for pushing the push rod is also sleeved on the push rod remaining outside the second opening. Preferably, when the button is driven by the connecting rod to reset, it is flush with the edge of the base.

[0020] Specifically, the fixing and locking assembly further includes a first stop strip and / or a second stop strip respectively fixed on the base. Among them, the first stop strip is arranged opposite to the limiting body, and the second stop strip is perpendicular to the first stop strip and is located outside one end of the first stop strip away from the push rod. The first stop strip, the limiting body and the second stop strip enclose a fixing groove opening towards the user to accommodate the placement of the reagent kit.

[0021] Preferably:

[0022] The first stop strip, the second stop strip and the limiting body have the same height and width, and / or

[0023] The unilateral distance between the fixing groove and the reagent kit is not greater than 0.7 mm.

[0024] Specifically, at least one elastic clamping part installation groove is further provided on the side of the first stop strip close to the reagent kit to install an elastic clamping part. The elastic clamping part is used for clamping the reagent kit. Preferably, the elastic clamping part is a marble.

[0025] The present invention also provides a fixing device for a reagent kit, which has any one of the fixing and locking assemblies and a base as described in the foregoing technical solutions. The base is used for placing the reagent kit and fixing the fixing and locking assembly.

[0026] The present invention also provides a purification device, which has any one of the fixing and locking assemblies as described in the foregoing technical solutions or has the fixing device as described in the foregoing technical solutions.

[0027] Specifically, the purification device further includes any one or more of the following:

[0028] (1) A magnetic bar assembly, including a magnetic bar holder for mounting the magnetic bar;

[0029] (2) A magnetic bar sleeve assembly, including a magnetic bar sleeve holder for mounting the magnetic bar sleeve, the magnetic bar sleeve holder being located below the magnetic bar holder, and each magnetic bar can correspondingly enter the corresponding magnetic bar sleeve;

[0030] (3) A working chamber for arranging the magnetic bar assembly, the magnetic bar sleeve assembly and the placement assembly;

[0031] (4) A moving mechanism for driving the magnetic bar sleeve holder and / or the magnetic bar holder to move vertically and / or horizontally. Further, the moving mechanism includes a horizontal moving mechanism and a vertical moving mechanism. Further, the moving mechanism includes a horizontal moving mechanism for driving the magnetic bar assembly and the magnetic bar sleeve assembly to move horizontally, a first vertical moving mechanism for driving the magnetic bar assembly to move vertically, and a second vertical moving mechanism for driving the magnetic bar sleeve assembly to move vertically;

[0032] (5) A circuit structure, including an integrated circuit board for controlling the purification device to perform purification operations;

[0033] (6) A heat dissipation device for dissipating heat from the working chamber;

[0034] (7) A disinfection device for disinfecting the working chamber.

[0035] The beneficial effects of the present invention are as follows:

[0036] (1) The fixed locking assembly provided by the present invention stably and firmly positions and abuts against the reagent kit by rotating the fixing part, and the reagent kit does not shift or even be lifted during the purification process;

[0037] (2) It is simple to put the reagent kit in, and it is not necessary to use a very large force to fix and position the reagent kit, which is convenient to use;

[0038] (3) Adjacent reagent kits share the same fixed locking assembly. The user presses the button, and the fixing part can be rotated to lock adjacent reagent kits simultaneously on the left and right;

[0039] (4) It can be judged whether the reagent kit is locked after being placed by whether the button is flush with the edge of the base. If the button is flush with the edge of the base, the reagent kit is locked; if the button is not flush with the edge of the base, the reagent kit is not locked. Through visual judgment, the situation that the reagent kit is not locked can be detected in time;

[0040] (5) The abutting portion has a larger size than the position-limiting size for the marbles, and it can be used compatibly when there are dimensional errors or certain deformations at the edge of the reagent kit. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] In order to more clearly illustrate the technical solutions of the present invention, the drawings required for the present invention will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0042] Figure 1 is a schematic structural view of an embodiment of the fixed locking assembly;

[0043] Figure 2 is a schematic structural view of another perspective of an embodiment of the fixed locking assembly;

[0044] Figure 3 is a schematic structural view of the positioning portion and the rotation fixing portion of an embodiment of the fixed locking assembly;

[0045] Figure 4 is a schematic structural view of the button of an embodiment of the fixed locking assembly;

[0046] Figure 5 is a schematic structural view of another embodiment of the fixed locking assembly;

[0047] Figure 6 is a schematic structural view of the limit main body of another embodiment of the fixed locking assembly;

[0048] Figure 7 is a schematic view of the button being flush with the edge of the base in an embodiment of the fixing device;

[0049] Figure 8 is a top view of the button being flush with the edge of the base in an embodiment of the fixing device;

[0050] Figure 9 is a schematic view of the rotation fixing portion abutting against the reagent kit in an embodiment of the fixing device;

[0051] Figure 10 is a schematic view of the button not being flush with the edge of the base in an embodiment of the fixing device;

[0052] Figure 11 is a schematic view of the assembly of the fixed locking assembly or the fixing device with the magnetic rod assembly and the magnetic rod sleeve assembly in an embodiment of the purification equipment;

[0053] Figure 12 is a schematic structural view of the moving mechanism in an embodiment of the purification equipment.

[0054] Among them, each reference numeral in the figure: 1. positioning part; 2. rotation fixing part; 21. abutting part; 3. connecting rod; 31. pin; 4. pushing part; 41. pushing member; 42. elastic member; 43. button; 5. limiting main body; 51. opening groove; 511. front inner wall; 513. top wall (L is the length of the top wall); 52. through hole; 522. second opening; 53. first limiting structure; 54. second limiting structure; 6. fixing groove; 61. first stop bar; 62. second stop bar; 7. base; 8. reagent kit; 9. magnetic bar assembly; 10. magnetic bar sleeve assembly; 11. moving mechanism.

[0055] 512: rear inner wall (not shown in the figure). For the convenience of description, the rear inner wall is labeled "512" hereinafter;

[0056] 521: first opening (not shown in the figure). For the convenience of description, the first opening is labeled "521" hereinafter; Detailed implementation manners

[0057] Next, the technical solutions in the present invention will be clearly and completely described in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0058] In the present invention, "front" and "rear" extend in the longitudinal axis (Y-axis) direction with the user as the zero point of the coordinate axis. Closer to "front" means farther from the user, and closer to "rear" means closer to the user.

[0059] A fixing and locking assembly provided by the present invention is used to lock and fix a reagent kit 8 placed on a base 7, and includes: a positioning part 1, a connecting rod 3, a rotation fixing part 2, and a pushing part 4, wherein;

[0060] One end of the connecting rod 3 is rotatably connected to the pushing part 4, and the other end is rotatably connected to the rotation fixing part 2;

[0061] The positioning part 1 is used to be fixed on the base 7; the rotation fixing part 2 is sleeved on the positioning part 1 and can be driven by the connecting rod 3 to rotate on the positioning part 1; the pushing part 4 is used to push the connecting rod 3 to drive the rotation fixing part 2:

[0062] When the pushing part 4 pushes the connecting rod 3, the connecting rod 3 drives the rotation fixing part 2 to rotate to an appropriate position to separate from the reagent kit 8, thereby realizing the fixing and unlocking of the reagent kit;

[0063] When the pushing part 4 drives the connecting rod 3 to reset, the connecting rod 3 drives the rotation fixing part 2 to rotate to an appropriate position to abut against the reagent kit 8, thereby realizing the locking and fixing of the reagent kit.

[0064] Specifically: The base 7 in this text refers to any plane used to place the kit during use, not limited to the base of the device, such as a desktop, a laboratory bench, etc.; the pushing in this text refers to moving the pushing part 4 forward compared to its starting position. At this time, the connecting rod 3 is driven by the pushing part 4 and also deviates from its initial position. The reset refers to the connecting rod 3 returning to its initial position driven by the backward movement of the pushing part 4.

[0065] The fixed locking assembly provided by the present invention stably and firmly abuts and positions the kit 8 by rotating the fixing part 2. The kit 8 does not displace or even be lifted during the purification process. The kit 8 is simple to put in and take out, and there is no need to use a very large force to complete the taking, fixing, and positioning of the kit 8, which is convenient to use.

[0066] In one embodiment, as Figure 1-2 shown, the pushing part 4 has a pushing member 41 and an elastic member 42. When pushing is performed, the pushing member 41 is pushed and the elastic member 42 is compressed. When the pushing is cancelled, the pushing member 41 drives the connecting rod 3 to reset under the elastic return of the elastic member 42. In a specific example, the elastic member 42 is a spring. The elastic member can be connected between the elastic member and the connecting rod, or can be sleeved on the pushing member. In a specific example, the pushing member 41 is a push rod, and the spring is sleeved on the push rod.

[0067] In one embodiment, the push rod and the connecting rod 3 are rotatably connected by a pin 31. This can enable: when the pushing part 4 is pushed, it moves forward, and when the pushing is cancelled, it can move backward and drive the connecting rod 3 to reset.

[0068] In one embodiment, as Figure 3 shown, the rotating fixing part 2 is sleeved on the positioning part 1 through a bearing. Rotating through the bearing can increase the smoothness and service life. In a specific example, the bearing is a double-row bearing. A double-row bearing is two bearings sleeved together, which is thicker than a single bearing and has better rotational stability. Specifically, the rotating fixing part 2 rotates around the positioning part 1 as the axis, that is, although the rotating fixing part 2 rotates, it does not displace itself, further limiting the moving position of the connecting rod 3.

[0069] In one embodiment, the fixed locking assembly further includes: a limiting body 5 fixed on the base 7. A through hole 52 is provided on the limiting body 5. One end of the push rod extends out from the first opening 521 of the through hole 52 and is rotatably connected to the connecting rod 3. The other end of the push rod remains outside the second opening 522 of the through hole 52. The spring is limited in the through hole 52 to be compressed or rebound. The beneficial effect is that the forward and backward movement of the pushing member 41 is further limited by the through hole 52, which can ensure linear movement. The elastic member 42 is also limited within the through hole 52, further limiting the movement of the pushing portion 4 and reducing the movement deviation of the pushing portion 4.

[0070] In one embodiment, the limiting body 5 is provided with a first limiting structure 53 and / or a second limiting structure 54: The first limiting structure 53 is used to limit the moving distance of the push rod during reset. In a specific example, the first limiting structure 53 is arranged as follows: There is a protrusion below the first opening 521, and a limiting groove is provided on the protrusion. The limiting groove is used to limit the insertion pin 31 to limit the moving distance; In another specific example, the second limiting structure 54 is used to limit the rotation angle of the rotation fixing portion 2 during pushing; In another embodiment, the limiting structure is a limiting block provided on the limiting body 5, which is used to limit the position of the connecting rod 3 when it is pushed to limit the rotation angle. The beneficial effect is that by setting the first limiting structure 53 to limit the reset and the second limiting structure 54 to limit the pushing, the forward and backward movement of the pushing portion 4 is more precisely limited.

[0071] In one embodiment, as Figure 5-6 shown, the limiting body 5 is provided with an opening groove 51 facing the base 7. The opening groove 51 has two front and rear inner walls and a top wall 513 connecting the two inner walls. The through hole 52 penetrates the rear inner wall 512 of the opening groove 51 from one end of the limiting body 5 close to the push rod (that is, the first opening 521 is located on the rear inner wall 512). The first limiting structure 53 is provided on the rear inner wall 512, and the second limiting structure is provided on a part near the front inner wall 511 of the opening groove 51. The positioning portion 1 is arranged in the opening slot. The rotation fixing portion 2 has at least one abutting portion 21. When the rotation fixing portion 2 is pushed, the abutting portion 21 is separated from the kit 8 and is located within the opening groove 51. When the connecting rod 3 is reset, the abutting portion 21 extends out of the opening groove 51 and abuts against the kit 8: When there are multiple abutting portions 21, at least two of the multiple abutting portions 21 can correspond to one kit 8 at the same time, that is, it can abut against and separate from one side of a kit 8 to achieve locking and taking; It is also possible that at least two of the multiple abutting portions 21 respectively correspond to the adjacent kits 8, that is, it can respectively abut against and separate from the sides of the adjacent kits to achieve locking and taking. At this time, the positioning portion 1, the connecting rod 3, the rotation fixing portion 2 and the pushing portion 4 are located between the positions where the adjacent kits 8 are placed.

[0072] Specifically, the limiting main body 5 is provided with an opening groove 51. The positioning portion 1, the first limiting structure 53 and the second limiting structure 54 are all arranged in the opening groove 51. The rear inner wall 512 of the opening groove 51 is penetrated by a through-hole 52. The limiting main body 5 integrally accommodates the fixing and locking assembly, making the structure more compact and the limiting more reliable. The abutting portion 21 can be abutted against or separated from the reagent kit 8 by rotation so as to achieve the purpose of fixing or leaving the reagent kit. Moreover, when the abutting portion 21 leaves the reagent kit 8, it is received in the opening groove 51. When the abutting portion 21 abuts against the reagent kit 8, due to its relatively large clamping size, it can be compatibly used when there are dimensional errors or certain deformations at the edge of the reagent kit 8.

[0073] In one example, the overall shape of the limiting main body 5 is a cuboid.

[0074] In one embodiment, the rotating fixing portion 2 has two symmetric abutting portions 21 in its length direction. The two abutting portions 21 respectively correspond to two reagent kits 8 arranged side by side. At this time, as Figure 7 shown, the positioning portion 1, the connecting rod 3, the rotating fixing portion 2 and the pushing portion 4 are arranged between the placement positions of the two reagent kits 8.

[0075] When the rotating fixing portion 2 is pushed, the two abutting portions 21 are separated from the respective adjacent reagent kits 8 and are located in the opening groove 51. In one example, the straight line connecting the centers of the two abutting portions 21 is parallel to the length direction of the top wall 513. At this time, the rotating fixing portion 2 rotates to the maximum rotatable angle, and the reagent kit 8 is completely locked;

[0076] When the connecting rod 3 is reset, the two abutting portions 21 abut against the respective adjacent reagent kits 8 and are located outside the opening groove 51. In one example, the straight line connecting the centers of the two abutting portions 21 is perpendicular to the length direction of the top wall 513. At this time, the rotating fixing portion 2 is driven to its starting position, and the reagent kit 8 is released by the abutting portion 21. Specifically, the adjacent reagent kits 8 share the same fixing and locking assembly. When the user presses the button 43, the rotating fixing portion 2 can lock the adjacent reagent kits 8 simultaneously to the left and right. As Figure 6-7 shown, the direction of the length (L) of the top wall 513 is the front-back direction of the present application.

[0077] In another embodiment, the opening groove 51 is rectangular. Further, the overall width of the rotating fixing portion 2 is less than or equal to the width of the top wall 513. Specifically, the width of the top wall 513 is the direction perpendicular to the length direction (L) in the plane of the top wall 513. After the rotating fixing portion 2 rotates away from the reagent kit 8, it is entirely covered by the top wall 513.

[0078] In one embodiment, as Figure 4As shown, a button 43 for pushing the push rod is also sleeved on the push rod remaining outside the second opening 522. The button 43 helps the user to push the pushing portion 4. In one example, as Figure 7-9 shown, when the button 43 is driven by the connecting rod 3 to reset, it is flush with the edge of the base 7. Specifically, it can be judged whether the kit 8 is locked after being placed by whether the button 43 is flush with the edge of the base 7. If the button 43 is flush with the edge of the base 7, the kit 8 is locked. If the button 43 is not flush with the edge of the base 7, the kit 8 is not locked. Through visual judgment, the situation that the kit 8 is not locked can be detected in time.

[0079] In one embodiment, the base 7 is used to place a plurality of kits 8 side by side, and adjacent kits 8 share a fixed locking component. Specifically, adjacent kits 8 share the same fixed locking component. The user pushes the button 43 and rotates the fixing portion 2 to lock adjacent kits 8 simultaneously left and right.

[0080] In one embodiment, the fixed locking component further includes a first stop bar 61 and / or a second stop bar 62 respectively fixed on the base 7. Among them, the first stop bar 61 is arranged relative to the limiting body 5, and the second stop bar 62 is perpendicular to the first stop bar 61 and is located outside one end of the first stop bar 61 away from the push rod. As Figure 7-10 shown, the first stop bar 61, the limiting body 5 and the second stop bar 62 enclose a fixing groove 6 opening towards the user to accommodate the placement of the kit 8. Specifically, when the first stop bar 61, the limiting body 5 and the second stop bar 62 are completely attached, they all catch the edge of the kit 8, so that the kit 8 cannot move up and down, and the kit 8 will not be displaced or even lifted during the purification process.

[0081] In one example, the first stop bar 61, the second stop bar 62 and the limiting body 5 have the same height and width.

[0082] In another example, the unilateral distance between the fixing groove and the kit 8 is not greater than 0.7 mm. Specifically, the unilateral distance between the fixing groove and the kit 8 is not greater than 0.7 mm, which not only takes into account the dimensional tolerance of the kit, but also limits the size range of the gap between the fixing groove and the kit 8, ensuring the friction force between the fixing groove and the kit 8, thereby preventing the kit 8 from being displaced or even lifted during the purification process.

[0083] In one embodiment, at least one elastic clamping member mounting groove is further provided on the side of the first stop bar close to the kit 8 to mount an elastic clamping member. The elastic clamping member is used to clamp the kit. In one example, the elastic clamping member is a ball. Specifically, an elastic clamping member for clamping the kit 8 is provided on the first stop bar 61, increasing the friction force on the kit to prevent the kit 8 from being displaced or even lifted during the purification process.

[0084] As Figure 7-10 shown, the present invention further provides a fixing device for a kit 8, which has any one of the fixing and locking components and a base 7 in the foregoing technical solutions. The base 7 is used to place the kit 8 and fix the fixing and locking components.

[0085] As Figure 11-12 shown, the present invention further provides a purification device, which has any one of the fixing and locking components in the foregoing technical solutions or has the fixing device in the foregoing technical solutions.

[0086] In one embodiment, the purification device further includes any one or more of the following:

[0087] (1) A magnetic rod assembly 9, including a magnetic rod holder for magnetic rod installation;

[0088] (2) A magnetic rod sleeve assembly 10, including a magnetic rod sleeve holder for magnetic rod sleeve installation. The magnetic rod sleeve holder is located below the magnetic rod holder, and each magnetic rod can enter the corresponding magnetic rod sleeve;

[0089] (3) A working chamber, which is used to arrange the magnetic rod assembly 9, the magnetic rod sleeve assembly 10 and a placing assembly;

[0090] (4) A moving mechanism 11, which is used to drive the magnetic rod sleeve holder and / or the magnetic rod holder to move vertically and / or horizontally. Further, the moving mechanism includes a horizontal moving mechanism and a vertical moving mechanism. Further, the moving mechanism includes a horizontal moving mechanism for driving the magnetic rod assembly 9 and the magnetic rod sleeve assembly 10 to move horizontally, a first vertical moving mechanism for driving the magnetic rod assembly 9 to move vertically, and a second vertical moving mechanism for driving the magnetic rod sleeve assembly to move vertically;

[0091] (5) A circuit structure, including an integrated circuit board for controlling the purification device to perform purification operations;

[0092] (6) A heat dissipation device, which is used to dissipate heat from the working chamber;

[0093] (7) A disinfection device, which is used to disinfect the working chamber.

[0094] "Purification" in the present application is to extract or separate target biomolecules by using the magnetic bead purification method to obtain purified target biomolecules. The purified target biomolecules include but are not limited to nucleic acids and proteins. Purifying nucleic acids and purifying proteins have the same semantics as the common expressions "nucleic acid extraction" and "protein purification". In addition, the "purification" process may include a process of extracting from, for example, cell lysate and then purifying by magnetic bead adsorption, or may only be a process of purifying by magnetic bead adsorption.

[0095] In the above embodiments, the purification device is used for the purification of nucleic acids, proteins and genomes, immune cell sorting and bacterial enrichment, and / or the device is suitable for but not limited to porous reagent kits, large-capacity porous reagent kits, reagent kits for the extraction and purification of biomolecules, and reagent kits for the purification of biomolecules. The porous reagent kit and the reagent kit have the same meaning and are not particularly limited. Any commercially available porous reagent kit can be used, such as 24-well, 48-well, 96-well, 192-well, 384-well, 768-well or 1536-well; the large-capacity porous reagent kit refers to increasing the length of the processing wells and the processing volume on the basis of the standard porous reagent kit. For example, the sample addition plate disclosed in CN218491693 U contains at least one large-capacity well and at least two standard wells; the reagent kit for the extraction and purification of biomolecules and the reagent kit for the purification of biomolecules refer to the purification reagent kit designed with any set number of sample addition wells according to the purification requirements. Further, the purification reagent kit is added with purification reagents such as magnetic bead suspension, buffer solution, cleaning solution, elution solution, etc. before use.

[0096] The above are only the preferred embodiments of the present invention and are not intended to limit the protection scope of the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A fixing and locking assembly for a kit, which is used to lock and fix the kit placed on a base, and is characterized in that, Comprising: A positioning part, a connecting rod, a rotary fixing part and a pushing part, wherein, One end of the connecting rod is rotatably connected to the pushing part, and the other end is rotatably connected to the rotary fixing part; The positioning part is used to be fixed on the base; The rotary fixing part is sleeved on the positioning part and can be driven by the connecting rod to rotate on the positioning part; The pushing part is used to push the connecting rod to drive the rotary fixing part: When the pushing part pushes the connecting rod, the connecting rod drives the rotary fixing part to rotate to a suitable position to separate from the reagent kit, When the pushing part drives the connecting rod to reset, the connecting rod drives the rotary fixing part to rotate to a suitable position to abut against the reagent kit.

2. The fixed locking assembly according to claim 1, wherein: The pushing part has a pushing member and an elastic member, When the pushing is performed, the pushing member is pushed and the elastic member is compressed, When the pushing is cancelled, the pushing member drives the connecting rod to perform the reset under the rebound of the elastic member, Preferably, the elastic member is a spring. More preferably, the pushing member is a push rod, the spring is sleeved on the push rod. Further preferably, the push rod and the connecting rod are rotatably connected by a pin.

3. The fixed locking assembly according to claim 1, wherein: The rotary fixing part is sleeved on the positioning part through a bearing. Preferably, the bearing is a double-row bearing.

4. The fixed locking assembly according to claim 2, wherein: Further comprising: A limiting main body fixed on the base. The limiting main body is provided with a through hole. One end of the push rod extends out from the first opening of the through hole and is rotatably connected to the connecting rod. The other end of the push rod remains outside the second opening of the through hole. The spring is limited in the through hole to be compressed or rebound; Preferably, the limiting main body is provided with a first limiting structure and / or a second limiting structure: The first limiting structure is used to limit the moving distance of the push rod during the reset. Further preferably, the setting of the first limiting structure is: there is a protrusion below the first opening, and a limiting groove is opened on the protrusion. The limiting groove is used to limit the pin to limit the moving distance; The second limiting structure is used to limit the rotation angle of the rotary fixing part when the pushing is performed; Further, the limiting structure is a limiting block provided on the limiting main body, which is used to limit the position of the connecting rod when it is pushed to limit the rotation angle.

5. The fixed locking assembly according to claim 4, wherein: The limiting main body is provided with an opening groove facing the base. The opening groove has two inner walls in the front and back and a top wall connecting the two inner walls, The through hole penetrates the rear inner side wall of the opening groove from one end of the limiting main body close to the push rod, The first limiting structure is arranged on the rear inner wall, the second limiting structure is arranged on a part near the front inner wall of the opening groove, and the positioning part is arranged in the opening groove, The rotary fixing part has at least one abutting part. When the rotary fixing part is pushed, the abutting part separates from the reagent kit and is located in the opening groove. When the connecting rod resets, the abutting part extends out of the opening groove and abuts against the reagent kit; Preferably, the overall shape of the limiting main body is a cuboid.

6. The fixed locking assembly according to claim 5, wherein: The rotating fixing part has two symmetric abutting parts in its length direction, and the two abutting parts respectively correspond to two of the reagent kits arranged side by side. When the rotating fixing part is pushed, the two abutting parts are separated from the respective adjacent reagent kits and are located in the opening groove. Further, the straight line connecting the centers of the two abutting parts is parallel to the length direction of the top wall. When the connecting rod is reset, the two abutting parts abut against the respective adjacent reagent kits and are located outside the opening groove. Further, the straight line connecting the centers of the two abutting parts is perpendicular to the length direction of the top wall. Preferably, the opening groove is rectangular. Further, the overall width of the rotating fixing part is less than or equal to the width of the top wall.

7. The fixed locking assembly according to claim 4, wherein: A button for pushing the push rod is also sleeved on the push rod remaining outside the second opening. Preferably, when the button is driven by the connecting rod to be reset, it is flush with the edge of the base.

8. The fixed locking assembly according to any one of claims 1-7, characterized in that: It further includes a first stop strip and / or a second stop strip respectively fixed on the base. Wherein, the first stop strip is arranged opposite to the limiting body, the second stop strip is perpendicular to the first stop strip and is located outside one end of the first stop strip away from the push rod. The first stop strip, the limiting body and the second stop strip enclose a fixing groove opening towards the user to accommodate the placement of the reagent kit. Preferably: The first stop strip, the second stop strip and the limiting body have the same height and width, and / or The unilateral distance between the fixing groove and the reagent kit is not greater than 0.7 mm.

9. The fixed and tightened locking assembly according to claim 8, characterized in that: At least one elastic clamping part installation groove is further arranged on the side of the first stop strip close to the reagent kit to install an elastic clamping part. The elastic clamping part is used for clamping the reagent kit. Preferably, the elastic clamping part is a ball.

10. A fixing device for a kit, characterized in that: It has any one of the fixing and locking assemblies as claimed in claims 1-9 and a base, and the base is used for placing the reagent kit and fixing the fixing and locking assembly.

11. A purification device, characterized in that: It has any one of the fixing and locking assemblies as claimed in claims 1-9 or has the fixing device as claimed in claim 10.

12. The purification device according to claim 11, wherein, It further includes any one or more of the following: (1) A magnetic rod assembly, including a magnetic rod holder for magnetic rod installation; (2) A magnetic rod sleeve assembly, including a magnetic rod sleeve holder for magnetic rod sleeve installation. The magnetic rod sleeve holder is located below the magnetic rod holder, and each magnetic rod can correspondingly enter the corresponding magnetic rod sleeve; (3) A working chamber, used for arranging the magnetic rod assembly, the magnetic rod sleeve assembly and the placement assembly; (4) A moving mechanism, used for driving the magnetic rod sleeve holder and / or the magnetic rod holder to move vertically and / or horizontally. Further, the moving mechanism includes a horizontal moving mechanism and a vertical moving mechanism. Further, the moving mechanism includes a horizontal moving mechanism for driving the magnetic rod assembly and the magnetic rod sleeve assembly to move horizontally, a first vertical moving mechanism for driving the magnetic rod assembly to move vertically, and a second vertical moving mechanism for driving the magnetic rod sleeve assembly to move vertically; (5) A circuit structure, including an integrated circuit board for controlling the purification equipment to perform purification operations; (6) A heat dissipation device, used for dissipating heat from the working chamber; (7) Disinfection device, used for disinfecting the said working chamber.

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