Acaricide preparation and application thereof

Abstract

The invention belongs to the field of acaricides, and relates to a preparation of an acaricide and application thereof. The acaricide preparation comprises an active component, an agriculturally acceptable auxiliary agent and a carrier, the active component is an active component A and / or an active component B, the active component accounts for 1-70% of the weight of the preparation, the active component A is selected from compounds A1-A10, the active component B is flumetofen, and the weight ratio of the active component A to the active component B is 50: 1-1: 50. According to the preparation method, antimony trioxide serving as a suspending aid is added into a proper wetting dispersant system in the preparation under the condition of selecting and matching a proper auxiliary agent system, and a specific addition amount is given, so that the suspension rate of the preparation can be effectively improved; when the active substance particles are mixed with water and finally applied, the interaction of the two compounds can be effectively blocked, so that the self defect that the active substance particles with two different structures are incompatible is inhibited.

Description

Technical Field

[0001] The invention belongs to the field of acaricides and relates to a preparation of acaricides and application thereof. Background Art

[0002] The top ten miticides in China account for 70% of the total market share. The top five crops in China's miticide application fields are citrus, apples, vegetables, cotton, and potatoes. The largest application crop field is citrus, accounting for 52% of the total miticide market share. The application of miticides plays a key role in the growth of crops. At present, miticides include ethoxachlor (SYP-9625), spirotetramat, etoxazole, spirocyclopentane, cypermethrin, bifenazate, pyridaben, avermectin, hexathiapyr, fluazifop, etc.

[0003] If the above-mentioned compounds with acaricidal activity want to truly exert their efficacy, they must rely on pesticide formulation technology to give the compounds an applicatable formulation. At present, the technology for preparing compounds into applicatable formulations has been popularized, but the improvement of key performance in the formulation is still in the research stage, such as the improvement of formulation stability, the control of formulation particle size, the improvement of formulation suspension performance, etc., and the ultimate goal of these performance improvements is to make the biological activity of the compounds better exerted. For the suspension performance of pesticide formulations, it is one of the most important indicators affecting the activity of compounds, because after the compounds are prepared into formulations, they are diluted into liquid medicines for spraying to exert their efficacy. The suspension performance is the embodiment of the uniformity and effectiveness of the diluted liquid medicine. At present, the relevant standards of the pesticide industry include many product standards that require the suspension rate to be greater than or equal to 90%. This data is a threshold value. In the study, it was found that, especially for the current acaricides with severe resistance, a slight improvement in efficacy will also have a significant improvement in efficacy. Therefore, for the improvement of suspension performance, such as the suspension rate from greater than or equal to 90% to greater than or equal to 98%, it will be a very significant improvement.

[0004] During our research on mixed formulations, we found that when compound A1-A10 or A1-A10 is mixed with fluazifop to prepare a formulation, the suspension rate of the product will drop significantly, and such problems will occur during the shelf life of the product. In addition, the above problems will also occur when other miticides other than fluazifop, such as ethoclofen, spirotetramat, etoxazole, spirodiclofen, propargite, bifenazate, pyridaben, avermectin, and hexythiazox are mixed with compound A1-A10.

[0005] In the actual application process of most pesticide formulations, water is used for dilution. The active ingredients are dispersed and dissolved in water and suspended in water to exert their pesticidal effects. In compound formulations, the requirements for such suspension performance are even more stringent. If the diluted liquid of the product is not evenly dispersed and the suspension performance is poor, the suspension rate will be unqualified. According to the current suspension rate standard for formulations, the suspension rate should not be lower than 90% to indicate the successful development of the formulation. The detection method for the suspension rate of the formulation needs to be carried out according to the national standard GB / T14825.

[0006] Due to the introduction of compounding or solid-liquid dispersion systems, the suspension rate of the formulation will decrease significantly, resulting in an unqualified suspension rate and ultimately affecting the use of the formulation. Therefore, at present, there is an urgent need for a type of formulation and a matching system that can solve the problem of low suspension rate. Summary of the Invention

[0007] The purpose of the present invention is to provide a miticide formulation.

[0008] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0009] A miticide formulation includes active ingredients, agriculturally acceptable auxiliaries and carriers. The active ingredients are active component A and / or active component B. The active ingredients account for 1%-70% of the weight of the formulation. Among them, active component A is selected from compounds A1-A10, active component B is flubenzimine, and the weight ratio of active component A to active component B is 50:1-1:50; the active component A is one or more of the compounds with the following structures:

[0010]

[0011] The pesticide formulation is a granule, wettable powder, water dispersible granule, suspension, dispersible oil suspension, microcapsule suspension, suspension emulsion, soluble solution, emulsion in water, microemulsion, emulsifiable concentrate, dry suspension, water dispersible tablet, soluble granule, soluble powder, emulsifiable powder or emulsifiable granule.

[0012] The auxiliaries are one or more of a wetting and dispersing agent, a solvent, an oil base, a carrier, a capsule material, and a suspending agent.

[0013] The suspending agent is antimony trioxide, and the addition amount is 0%-5% of the mass of the formulation.

[0014] The auxiliaries are a wetting and dispersing agent and a suspending agent and one or more of a solvent, an oil base, a carrier, and a capsule material.

[0015] The wetting and dispersing agent is one or more of lignosulfonate, polyacrylate, polycarboxylate, carboxylate, carboxylic acid-based polymer copolymer, sulfonate, sulfate, phosphate, aryl ether phosphate, gemini-like amphiphilic surfactant complex, compounding aid of polyacrylate copolymer, polymer surfactant with special structure, EO / PO block polyether, polymer, block copolymer, single comb polymer, sodium salt of alkylnaphthalenesulfonic acid condensate + block copolymer, agricultural emulsifier T-20, agricultural emulsifier 0201B, agricultural emulsifier 0203B, agricultural emulsifier 1601, naphthalenesulfonate formaldehyde condensate, sodium salt of methylnaphthalenesulfonate formaldehyde condensate, polyvinyl alcohol, chitosan.

[0016] The wetting and dispersing agent is a mixture of lignosulfonate and one or more of the following substances; the following substances are polyacrylate, polycarboxylate, carboxylate, carboxylic acid-based polymer copolymer, sulfonate, sulfate, phosphate, aryl ether phosphate, gemini-like amphiphilic surfactant complex, compounding aid of polyacrylate copolymer, polymer surfactant with special structure, EO / PO block polyether, polymer, block copolymer, single comb polymer, sodium salt of alkylnaphthalenesulfonic acid condensate + block copolymer, agricultural emulsifier T-20, agricultural emulsifier 0201B, agricultural emulsifier 0203B, agricultural emulsifier 1601, naphthalenesulfonate formaldehyde condensate, sodium salt of methylnaphthalenesulfonate formaldehyde condensate, polyvinyl alcohol, chitosan.

[0017] When the wetting and dispersing agent contains lignosulfonate, a suspending agent is added, and the mass ratio of the suspending agent to the wetting and dispersing agent is 1:1.

[0018] An application of the acaricide preparation in the field of agricultural acaricides.

[0019] For the granule, by weight percentage, active ingredient A is 0.5% - 70%, active ingredient B is 0.5% - 70%, the wetting and dispersing agent is 1 - 15%, the suspending agent is 0% - 5%, and the balance is the carrier;

[0020] For the wettable powder, by weight percentage, active ingredient A is 0.5% - 70%, active ingredient B is 0.5% - 70%, the wetting and dispersing agent is 1 - 20%, the suspending agent is 0% - 5%, and the balance is the carrier;

[0021] For the water dispersible granule, by weight percentage, active ingredient A is 0.5% - 70%, active ingredient B is 0.5% - 70%, the wetting and dispersing agent is 1 - 20%, the suspending agent is 0% - 5%, and the balance is the carrier;

[0022] For the suspension concentrate, by weight percentage, active ingredient A is 0.5% - 70%, active ingredient B is 0.5% - 70%, the wetting and dispersing agent is 1% - 30%, the suspending agent is 0% - 5%, and the balance is deionized water.

[0023] For the dispersible oil suspension, by weight percentage, the active ingredient A is 0.5% - 70%, the active ingredient B is 0.5% - 70%, the wetting and dispersing agent is 1% - 30%, the suspending agent is 0% - 5%, and the balance is the dispersed phase oil base.

[0024] For the microcapsule suspension, by weight percentage, the active ingredient A is 0.5% - 70%, the active ingredient B is 0.5% - 70%, the wetting and dispersing agent is 1% - 20%, the capsule material is 1% - 5%, the suspending agent is 0% - 5%, and the balance is the dispersed phase oil base.

[0025] For the suspo-emulsion, by weight percentage, the active ingredient A is 0.5% - 70%, the active ingredient B is 0.5% - 70%, the solvent is 2% - 30%, the wetting and dispersing agent is 1% - 30%, the suspending agent is 0% - 5%, and the balance is deionized water.

[0026] For the soluble concentrate, by weight percentage, the active ingredient A is 0.5% - 70%, the active ingredient B is 0.5% - 70%, the wetting and dispersing agent is 1% - 30%, the suspending agent is 0% - 5%, and the balance is the solvent.

[0027] For the emulsion in water, by weight percentage, the active ingredient A is 0.5% - 70%, the active ingredient B is 0.5% - 70%, the solvent is 2% - 30%, the wetting and dispersing agent is 1% - 30%, the suspending agent is 0% - 5%, and the balance is deionized water.

[0028] For the microemulsion, by weight percentage, the active ingredient A is 0.5% - 70%, the active ingredient B is 0.5% - 70%, the solvent is 2% - 30%, the wetting and dispersing agent is 1% - 30%, the suspending agent is 0% - 5%, and the balance is deionized water.

[0029] For the emulsifiable concentrate, by weight percentage, the active ingredient A is 0.5% - 70%, the active ingredient B is 0.5% - 70%, the wetting and dispersing agent is 1% - 30%, the suspending agent is 0% - 5%, and the balance is the solvent.

[0030] For the dry flowable, by weight percentage, the active ingredient A is 0.5% - 70%, the active ingredient B is 0.5% - 70%, the wetting and dispersing agent is 5 - 70%, the suspending aid is 0.01 - 5%, the suspending agent is 0% - 5%, and the balance is the carrier;

[0031] For the water dispersible tablet, by weight percentage, the active ingredient A is 0.5% - 70%, the active ingredient B is 0.5% - 70%, the wetting and dispersing agent is 1 - 20%, the suspending aid is 0.01 - 5%, the tablet forming aid is 2 - 20%, the suspending agent is 0% - 5%, and the balance is the carrier;

[0032] For the soluble granule, by weight percentage, the active ingredient A is 0.5%-70%, the active ingredient B is 0.5%-70%, the wetting and dispersing agent is 1%-20%, the auxiliary suspending agent is 0.01%-5%, the suspending agent is 0%-5%, and the balance is the carrier;

[0033] For the soluble powder, by weight percentage, the active ingredient A is 0.5%-70%, the active ingredient B is 0.5%-70%, the wetting and dispersing agent is 1%-20%, the auxiliary suspending agent is 0.01%-5%, the suspending agent is 0%-5%, and the balance is the carrier;

[0034] For the emulsifiable powder, by weight percentage, the active ingredient A is 0.5%-70%, the active ingredient B is 0.5%-70%, the wetting and dispersing agent is 1%-40%, the auxiliary suspending agent is 0.01%-5%, the suspending agent is 0%-5%, and the balance is the carrier;

[0035] For the emulsifiable granule, by weight percentage, the active ingredient A is 0.5%-70%, the active ingredient B is 0.5%-70%, the wetting and dispersing agent is 1%-40%, the auxiliary suspending agent is 0.01%-5%, the suspending agent is 0%-5%, and the balance is the carrier.

[0036] Preferably,

[0037] For the granule, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 1%-15%, the suspending agent is 0.2%-5%, and the balance is the carrier;

[0038] For the wettable powder, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 1%-15%, the suspending agent is 0.2%-5%, and the balance is the carrier;

[0039] For the water dispersible granule, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 1%-15%, the suspending agent is 0.2%-5%, and the balance is the carrier;

[0040] For the suspending agent, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 1%-30%, the suspending agent is 0.2%-5%, and the balance is deionized water.

[0041] For the dispersible oil suspending agent, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 1%-30%, the suspending agent is 0.2%-5%, and the balance is the dispersed phase oil base.

[0042] For the microcapsule suspension, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 1%-20%, the capsule material is 1%-5%, the suspending agent is 0.2%-5%, and the balance is the dispersed phase oil base.

[0043] For the suspo-emulsion, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the solvent is 2%-30%, the wetting and dispersing agent is 1%-30%, the suspending agent is 0.2%-5%, and the balance is deionized water.

[0044] For the soluble concentrate, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 1%-30%, the suspending agent is 0.2%-5%, and the balance is the solvent.

[0045] For the emulsion in water, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the solvent is 2%-30%, the wetting and dispersing agent is 1%-30%, the suspending agent is 0.2%-5%, and the balance is deionized water.

[0046] For the microemulsion, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the solvent is 2%-30%, the wetting and dispersing agent is 1%-30%, the suspending agent is 0.2%-5%, and the balance is deionized water.

[0047] For the emulsifiable concentrate, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 1%-30%, the suspending agent is 0.2%-5%, and the balance is the solvent.

[0048] For the dry flowable, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 5-70%, the auxiliary suspending agent is 0.01-5%, the suspending agent is 0.2%-5%, and the balance is the carrier;

[0049] For the water dispersible tablet, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 1-20%, the auxiliary suspending agent is 0.01-5%, the tablet forming aid is 2-20%, the suspending agent is 0.2%-5%, and the balance is the carrier;

[0050] For the soluble granule, by weight percentage, the active ingredient A is 5%-40%, the active ingredient B is 5%-40%, the wetting and dispersing agent is 1-20%, the auxiliary suspending agent is 0.01-5%, the suspending agent is 0.2%-5%, and the balance is the carrier;

[0051] The soluble powder contains, by weight percentage, 5%-40% of active ingredient A, 5%-40% of active ingredient B, 1%-20% of wetting and dispersing agent, 0.01%-5% of auxiliary suspending agent, 0.2%-5% of suspending agent, and the balance is carrier;

[0052] The emulsifiable powder contains, by weight percentage, 5%-40% of active ingredient A, 5%-40% of active ingredient B, 1%-40% of wetting and dispersing agent, 0.01%-5% of auxiliary suspending agent, 0.2%-5% of suspending agent, and the balance is carrier;

[0053] The emulsifiable granule contains, by weight percentage, 5%-40% of active ingredient A, 5%-40% of active ingredient B, 1%-40% of wetting and dispersing agent, 0.01%-5% of auxiliary suspending agent, 0.2%-5% of suspending agent, and the balance is carrier.

[0054] Application of the preparation in the field of agricultural acaricides.

[0055] The wetting and dispersing agent is one or more of various salt surfactants, polymer copolymers, polyether surfactants, modified surfactants, polyvinyl alcohol, and chitosan; specifically including but not limited to lignosulfonate (SK-24N), polyacrylate (SD-811), polycarboxylate (SD816, SD819, Emulson 14105, SP-2750, D800, ULTRASURF 7023A, D-205 or D-305), carboxylate (SD815, SK-25CH or TANEMUL DA2880), carboxylic acid polymer copolymer (Atlox 4913), sulfonate (SK-20TX, SK-24R), sulfate (YUS-FS7PG), phosphate (YUS-FS3000), aryl ether phosphate (SK-33SC), gemini-like amphiphilic surfactant complex (SP-SC3 or SP-SC29), natural polymer modifier (Lamfix SO), compounding aid of polyacrylate copolymer (FS981), special structure polymer surfactant (SP-27001), EO / PO block polyether (D800 or Atlas G5000), polymer (PVA), block copolymer (DB08, AMS303 or XA265), polymer surfactant with "ABA" regular structure (SP-2836), TWEEN L 1505-LQ-(AP), TWEEN L0515-LQ-(AP), TWEEN L 1010-LQ-(AP), ATPLUS245-LQ-(TH), ATPLUS UEP 100LQ(CQ), Greenwet 7600, hydroxy polyoxyethylene block copolymer (Agrilan 788 or Ethylan NS-500LQ), single comb polymer (Agrilan 755), sodium salt of alkyl naphthalene sulfonic acid condensate + block copolymer (Morwet D500), agricultural emulsion T-20, agricultural emulsion 0201B, agricultural emulsion 0203B, agricultural emulsion 1601, naphthalene sulfonate formaldehyde condensate, sodium salt of methyl naphthalene sulfonate formaldehyde condensate, etc. One or more of them.

[0056] The solvent is one or more of toluene, xylene, solvent oil, fatty acid methyl ester, methyl oleate, liquid paraffin, epoxidized soybean oil, N,N-dimethylformamide, N,N-dimethyldecanamide, sec-butyl acetate, cyclohexanone, and dimethyl sulfoxide.

[0057] The oil base is one or more of mineral oils, vegetable oils and their esters.

[0058] The carrier can be, but is not limited to, one or more of clay, rock powder, chalk, quartz, clay, montmorillonite, sodium sulfate, silica, diatomaceous earth, pumice, gypsum, talc, bentonite, kaolin, attapulgite, light calcium carbonate, pottery clay, montmorillonite, magnesium aluminum silicate, activated clay, silica white, ammonium sulfate, benzofuran resin, superphosphate, alumina, calcite, marble, pumice, etc. Preferably, it is one or several of clay, rock powder, diatomaceous earth, bentonite, kaolin, attapulgite, light calcium carbonate, montmorillonite, activated clay, silica white.

[0059] It may also include thickening substances, which can be one or several of xanthan gum, gelatin, gum arabic, polyvinyl acetate, polyvinylpyrrolidone, magnesium aluminum silicate, polyethylene glycol, phenolic resin, sodium polyacrylate, polyurea prepolymer, styrene maleic anhydride copolymer, shellac, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, and sodium alginate, which can improve the stability of the preparation to a certain extent.

[0060] If required by the application, defoamers can also be added. The defoamers can be one or several of SAG1522, silicone, C8 - 10 fatty alcohols, phosphate esters, C10 - 20 saturated fatty acids (such as capric acid) and amides, or others.

[0061] If long - term storage is needed, preservatives can be added, which can be one or several of sodium benzoate, Kathon (2 - methyl - 4 - isothiazolin - 3 - one and (B) 5 - chloro - 2 - methyl - 4 - isothiazolin - 3 - one), potassium sorbate, sodium dehydroacetate, or others.

[0062] The capsule material for preparing the microcapsule suspension can be, but is not limited to, urea - formaldehyde prepolymer.

[0063] The tablet - forming aids can be starch, modified starch, cellulose, modified cellulose, various resins, polyvinylpyrrolidone, etc. The filler refers to a mixture of one or more fillers.

[0064] The pesticide preparation also includes some commonly known substances in the industry, such as pH regulators, antifreeze agents, preservatives, quartz sand, polyvinyl alcohol, glucose, ammonium sulfate, etc. And the preparation process of the preparation can be a conventional method.

[0065] Compound A or / and Compound B can also be prepared into other applicable preparation dosage forms besides the above - mentioned dosage forms, such as, but not limited to, microcapsule suspension - suspension agent, microcapsule suspension - emulsion in water, microcapsule suspension - suspo - emulsion.

[0066] Before use, the acaricide preparation of the present invention can be diluted by the user or directly sprayed after adding water.

[0067] The advantages of the present invention:

[0068] The present invention uses a compound as active substance A or / and active substance B as the active ingredient, and prepares it into a pesticide formulation, which relates to a dosage form applicable to the pesticide formulation that can be prepared. The obtained various types of pesticide formulations solve the problems that in the existing dosage forms, under the conditions specified by the national standards during the shelf life, the active substances are non-uniform in various forms of particles in the solid-liquid dispersion system, and the suspension rate of the active substances decreases when diluted in water for application. On the one hand, this problem will make the preparation product not meet the national standards and be an unqualified product. Furthermore, under the condition of selecting a suitable adjuvant system, the present invention adds a suitable wetting and dispersing agent system as a suspending agent - antimony trioxide in the preparation and gives a specific addition amount, which can effectively improve the suspension rate of the preparation. When antimony trioxide is added to the system and finally applied after mixing with water, it can effectively block the interaction between the two types of compounds, thereby inhibiting the self-defects of the incompatible particles of the two types of active substances with different structures, solving the problem of low suspension rate of the mixed preparation in the prior art, making the suspension rate of the preparation qualified, ensuring the product performance, and achieving unexpected effects. Specific Embodiments

[0069] The following specific examples are used to further illustrate the present invention in detail, but the present invention is by no means limited to these examples, and the methods well known to those skilled in the art are all included in the scope of the present invention.

[0070] The acaricide formulation of the present invention uses an adjuvant system combination and the interaction of two active substances, so that during the conventional shelf life, through the compatibility of the adjuvant system and the addition of stabilizing substances, the suspension performance of the active components is greatly improved and the suspension rate is qualified.

[0071] In the following formulations, the percentages and parts are all by weight. The active ingredients are added according to the dose after converting to 100% purity prepared according to the records of the prior art. Specifically, compound A1 can be prepared according to the records of WO2022166837A1, compound A2 can be prepared according to the records of WO2021056922A1, compound A3 can be prepared according to the records of WO2022179501A1, compound A4 can be prepared according to the records of CN104350039B, compound A5 can be prepared according to the records of CN108276358B, compound A6 can be prepared according to the records of CN114853647A, compound A7 can be prepared according to the records of CN102770430 B, compound A9 can be prepared according to the records of WO2007026965(A1), and compound A10 can be prepared according to the records of CN102639529B. Compound B is flubenzolate, a biphenyl compound disclosed in Chinese invention patent CN105541682A. The proportions of each component are by weight percentage, and all other raw materials are commercially available products.

[0072] Formulation Examples

[0073] The following examples are only representative. According to the above technical solutions, for other formulations with different contents and ratios, as long as they are introduced according to the following formulation and process, the corresponding applicable formulations and technical effects can also be obtained.

[0074] Comparative Example 1. 20% Compound A1·Flubenzimine Suspension Concentrate

[0075] According to the formulation requirements, 10% of Compound A1, 10% of flubenzimine, 10% of SK-20TX, 10% of SP27001, 0.12% of xanthan gum, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 20% Compound A1·Flubenzimine Suspension Concentrate.

[0076] Example 1-1. 20% Compound A1·Flubenzimine Suspension Concentrate

[0077] According to the formulation requirements, 10% of Compound A1, 10% of flubenzimine, 10% of SK-20TX, 10% of SP27001, 0.12% of xanthan gum, 0.3% of antimony trioxide, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 20% Compound A1·Flubenzimine Suspension Concentrate.

[0078] Example 1-2. 20% Compound A1·Flubenzimine Suspension Concentrate

[0079] According to the formulation requirements, 10% of Compound A1, 10% of flubenzimine, 10% of SK-20TX, 10% of SP27001, 0.12% of xanthan gum, 0.3% of antimony trioxide, 0.3% of SK-24N, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 20% Compound A1·Flubenzimine Suspension Concentrate.

[0080] Comparative Example 2. 30% Compound A2·Flubenzimine Suspension Concentrate

[0081] According to the formulation requirements, 15% of Compound A2, 15% of flubenzimine, 10% of SP-27001, 10% of AMS303, 0.10% of xanthan gum, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 30% Compound A2·Flubenzimine Suspension Concentrate.

[0082] Example 2-1. 30% Compound A2·Flubenzimine Suspension Concentrate

[0083] According to the formulation requirements, 15% of Compound A2, 15% of flubenzimine, 10% of SP-27001, 10% of AMS303, 0.10% of xanthan gum, 0.4% of antimony trioxide, 0.4% of SK-24N, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 30% Compound A2·Flubenzimine Suspension Concentrate.

[0084] Example 2-2. 30% Compound A2·Flubenzimine Suspension Concentrate

[0085] According to the formulation requirements, 15% of Compound A2, 15% of flubenzimine, 10% of SP-27001, 10% of AMS303, 0.10% of xanthan gum, 0.4% of antimony trioxide, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 30% Compound A2·Flubenzimine Suspension Concentrate.

[0086] Comparative Example 3. 35% Compound A3·Flubenzimine Suspension Concentrate

[0087] According to the formulation requirements, 25% of Compound A3, 10% of flubenzimine, 10% of SD-811, 10% of YUS-FS7PG, 0.10% of xanthan gum, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 35% Compound A3·Flubenzimine Suspension Concentrate.

[0088] Example 3-1. 35% Compound A3·Flubenzimine Suspension Concentrate

[0089] According to the formulation requirements, 25% of Compound A3, 10% of flubenzimine, 10% of SD-811, 10% of YUS-FS7PG, 0.10% of xanthan gum, 1% of antimony trioxide, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 35% Compound A3·Flubenzimine Suspension Concentrate.

[0090] Example 3-2. 35% Compound A3·Flubenzimine Suspension Concentrate

[0091] According to the formula requirements, 25% of compound A3, 10% of flubenzimine, 10% of SD-811, 10% of YUS-FS7PG, 0.10% of xanthan gum, 1% of antimony trioxide, 1% of SK-24N, and water are added to make up 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 35% compound A3·flubenzimine suspension concentrate.

[0092] Comparative Example 4. 30% compound A4·flubenzimine suspension concentrate

[0093] According to the formula requirements, 15% of compound A4, 15% of flubenzimine, 10% of SD816, 10% of Morwet D500, 0.08% of xanthan gum, 2% of antimony trioxide, 2% of SK-24N, and water are added to make up 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 30% compound A4·flubenzimine suspension concentrate.

[0094] Example 4-1. 30% compound A4·flubenzimine suspension concentrate

[0095] According to the formula requirements, 15% of compound A4, 15% of flubenzimine, 10% of SD816, 10% of Morwet D500, 0.08% of xanthan gum, 2% of antimony trioxide, and water are added to make up 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 30% compound A4·flubenzimine suspension concentrate.

[0096] Example 4-2. 30% compound A4·flubenzimine suspension concentrate

[0097] According to the formula requirements, 15% of compound A4, 15% of flubenzimine, 10% of SD816, 10% of Morwet D500, 0.08% of xanthan gum, 2% of antimony trioxide, 2% of SK-24N, and water are added to make up 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 30% compound A4·flubenzimine suspension concentrate.

[0098] Comparative Example 5. 40% compound A5·flubenzimine suspension concentrate

[0099] According to the formulation requirements, 20% of compound A5, 20% of flubenzimine, 10% of DB08, 10% of SP-SC3, 0.06% of xanthan gum, and the balance of water to 100% are successively added to a mixing tank for mixing. First, it is subjected to high-shear for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain a 40% suspension concentrate of compound A5·flubenzimine.

[0100] Example 5-1. 40% suspension concentrate of compound A5·flubenzimine

[0101] According to the formulation requirements, 20% of compound A5, 20% of flubenzimine, 10% of DB08, 10% of SP-SC3, 0.06% of xanthan gum, 2% of antimony trioxide, and the balance of water to 100% are successively added to a mixing tank for mixing. First, it is subjected to high-shear for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain a 40% suspension concentrate of compound A5·flubenzimine.

[0102] Example 5-2. 40% suspension concentrate of compound A5·flubenzimine

[0103] According to the formulation requirements, 20% of compound A5, 20% of flubenzimine, 10% of DB08, 10% of SP-SC3, 0.06% of xanthan gum, 2% of antimony trioxide, 2% of SK-24N, and the balance of water to 100% are successively added to a mixing tank for mixing. First, it is subjected to high-shear for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain a 40% suspension concentrate of compound A5·flubenzimine.

[0104] Comparative Example 6. 20% suspension concentrate of compound A6·flubenzimine

[0105] According to the formulation requirements, 10% of compound A6, 10% of flubenzimine, 10% of agricultural emulsifier 0201B, 10% of SP-SC29, 0.16% of xanthan gum, and the balance of water to 100% are successively added to a mixing tank for mixing. First, it is subjected to high-shear for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain a 20% suspension concentrate of compound A6·flubenzimine.

[0106] Example 6-1. 20% suspension concentrate of compound A6·flubenzimine

[0107] According to the formulation requirements, 10% of compound A6, 10% of flubenzimine, 10% of agricultural emulsifier 0201B, 10% of SP-SC29, 0.16% of xanthan gum, 4% of antimony trioxide, and the balance of water to 100% are successively added to a mixing tank for mixing. First, it is subjected to high-shear for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain a 20% suspension concentrate of compound A6·flubenzimine.

[0108] Example 6 - 2. 20% Compound A6·Flubenzimine Suspension Concentrate

[0109] According to the formulation requirements, 10% of Compound A6, 10% of flubenzimine, 10% of agricultural emulsifier 0201B, 10% of SP - SC29, 0.16% of xanthan gum, 4% of antimony trioxide, 4% of SK - 24N, and water are added up to 100% and successively added to a mixing tank for mixing. First, it is coarsely pulverized and homogenized by high - shear, and then pumped into a sand mill for fine grinding to obtain 20% Compound A6·Flubenzimine Suspension Concentrate.

[0110] Comparative Example 7. 40% Compound A7·Flubenzimine Suspension Concentrate

[0111] According to the formulation requirements, 20% of Compound A7, 20% of flubenzimine, 10% of Emulson 14105, 10% of D800, 0.06% of xanthan gum, and water are added up to 100%. They are successively added to a mixing tank for mixing. First, it is coarsely pulverized and homogenized by high - shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A7·Flubenzimine Suspension Concentrate.

[0112] Example 7 - 1. 40% Compound A7·Flubenzimine Suspension Concentrate

[0113] According to the formulation requirements, 20% of Compound A7, 20% of flubenzimine, 10% of Emulson 14105, 10% of D800, 0.06% of xanthan gum, 5% of antimony trioxide, and water are added up to 100%. They are successively added to a mixing tank for mixing. First, it is coarsely pulverized and homogenized by high - shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A7·Flubenzimine Suspension Concentrate.

[0114] Example 7 - 2. 40% Compound A7·Flubenzimine Suspension Concentrate

[0115] According to the formulation requirements, 20% of Compound A7, 20% of flubenzimine, 10% of Emulson 14105, 10% of D800, 0.06% of xanthan gum, 5% of antimony trioxide, 5% of SK - 24N, and water are added up to 100%. They are successively added to a mixing tank for mixing. First, it is coarsely pulverized and homogenized by high - shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A7·Flubenzimine Suspension Concentrate.

[0116] Comparative Example 8. 40% Compound A8·Flubenzimine Suspension Concentrate

[0117] According to the formulation requirements, 20% of Compound A8, 20% of pyridalyl, 10% of SK-20TX, 10% of YUS-FS3000, 0.04% of xanthan gum, and water are added up to 100%. They are added to the mixing tank in sequence and mixed. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A8·pyridalyl suspension concentrate.

[0118] Example 8-1. 40% Compound A8·pyridalyl suspension concentrate

[0119] According to the formulation requirements, 20% of Compound A8, 20% of pyridalyl, 10% of SK-20TX, 10% of YUS-FS3000, 0.04% of xanthan gum, 2% of antimony trioxide, and water are added up to 100%. They are added to the mixing tank in sequence and mixed. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A8·pyridalyl suspension concentrate.

[0120] Example 8-2. 40% Compound A8·pyridalyl suspension concentrate

[0121] According to the formulation requirements, 20% of Compound A8, 20% of pyridalyl, 10% of SK-20TX, 10% of YUS-FS3000, 0.04% of xanthan gum, 2% of antimony trioxide, 2% of SK-24N, and water are added up to 100%. They are added to the mixing tank in sequence and mixed. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A8·pyridalyl suspension concentrate.

[0122] Comparative Example 9. 40% Compound A9·pyridalyl suspension concentrate

[0123] According to the formulation requirements, 20% of Compound A9, 20% of pyridalyl, 10% of XA265, 10% of Agrilan755, 0.04% of xanthan gum, and water are added up to 100%. They are added to the mixing tank in sequence and mixed. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A9·pyridalyl suspension concentrate.

[0124] Example 9-1. 40% Compound A9·pyridalyl suspension concentrate

[0125] According to the formulation requirements, 20% of Compound A9, 20% of pyridalyl, 10% of XA265, 10% of Agrilan755, 0.04% of xanthan gum, 2% of antimony trioxide, and water are added up to 100%. They are added to the mixing tank in sequence and mixed. First, they are coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A9·pyridalyl suspension concentrate.

[0126] Example 9 - 2. 40% Compound A9·Halfenprox Suspension Concentrate

[0127] According to the formulation requirements, 20% of Compound A9, 20% of halfenprox, 10% of XA265, 10% of Agrilan755, 0.04% of xanthan gum, 2% of antimony trioxide, 2% of SK - 24N, and the balance made up with water to 100% were successively added to a mixing tank for mixing. First, it was roughly crushed and homogenized by high - shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A9·Halfenprox Suspension Concentrate.

[0128] Comparative Example 10. 40% Compound A10·Halfenprox Suspension Concentrate

[0129] According to the formulation requirements, 20% of Compound A10, 20% of halfenprox, 10% of SP - 27001, 10% of AMS303, 0.10% of xanthan gum, and the balance made up with water to 100% were successively added to a mixing tank for mixing. First, it was roughly crushed and homogenized by high - shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A10·Halfenprox Suspension Concentrate.

[0130] Example 10 - 1. 40% Compound A10·Halfenprox Suspension Concentrate

[0131] According to the formulation requirements, 20% of Compound A10, 20% of halfenprox, 10% of SP - 27001, 10% of AMS303, 0.10% of xanthan gum, 1% of antimony trioxide, and the balance made up with water to 100% were successively added to a mixing tank for mixing. First, it was roughly crushed and homogenized by high - shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A10·Halfenprox Suspension Concentrate.

[0132] Example 10 - 2. 40% Compound A10·Halfenprox Suspension Concentrate

[0133] According to the formulation requirements, 20% of Compound A10, 20% of halfenprox, 10% of SP - 27001, 10% of AMS303, 0.10% of xanthan gum, 1% of antimony trioxide, 1% of SK - 24N, and the balance made up with water to 100% were successively added to a mixing tank for mixing. First, it was roughly crushed and homogenized by high - shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A10·Halfenprox Suspension Concentrate.

[0134] Comparative Example 11. 10% Compound A1·Halfenprox Emulsion in Water

[0135] According to the formulation requirements, 5% of compound A1, 5% of flubenzimine, 30% of S200, 20% of D-205, 20% of DB08, and water are added to make up 100%. Stir and mix evenly to obtain 10% compound A1·flubenzimine aqueous emulsion.

[0136] Example 11. 10% compound A1·flubenzimine aqueous emulsion

[0137] According to the formulation requirements, 5% of compound A1, 5% of flubenzimine, 30% of S200, 20% of D-205, 20% of DB08, 0.5% of antimony trioxide, 0.5% of SK-24N, and water are added to make up 100%. Stir and mix evenly to obtain 10% compound A1·flubenzimine aqueous emulsion.

[0138] Comparative Example 12. 30% compound A2·flubenzimine dispersible oil suspension concentrate

[0139] According to the formulation requirements, 15% of compound A2, 15% of flubenzimine, 10% of agricultural emulsifier T-20, 10% of Ethylan NS-500LQ, 1% of white carbon black, and methyl oleate are added to make up 100%. Add them to the mixing tank in sequence and mix. First, conduct coarse crushing and homogenization through high shear, and then pump them into a sand mill for fine grinding to obtain 30% compound A2·flubenzimine dispersible oil suspension concentrate.

[0140] Example 12. 30% compound A2·flubenzimine dispersible oil suspension concentrate

[0141] According to the formulation requirements, 15% of compound A2, 15% of flubenzimine, 10% of agricultural emulsifier T-20, 10% of Ethylan NS-500LQ, 2% of antimony trioxide, 2% of SK-24N, 1% of white carbon black, and methyl oleate are added to make up 100%. Add them to the mixing tank in sequence and mix. First, conduct coarse crushing and homogenization through high shear, and then pump them into a sand mill for fine grinding to obtain 30% compound A2·flubenzimine dispersible oil suspension concentrate.

[0142] Comparative Example 13. 15% compound A3·flubenzimine microemulsion

[0143] According to the formulation requirements, 5% of compound A3, 10% of flubenzimine, 30% of S150, 20% of agricultural emulsifier 0201B, 20% of D800, and water are added to make up 100%. Stir and mix evenly to obtain 15% compound A3·flubenzimine microemulsion.

[0144] Example 13. 15% compound A3·flubenzimine microemulsion

[0145] According to the formulation requirements, 35% of compound A3, 10% of flubenzimine, 30% of S150, 20% of agricultural emulsifier 0201B, 20% of D800, 1% of antimony trioxide, 1% of SK-24N, and water are added to make up to 100%. After stirring and mixing evenly, 15% compound A3·flubenzimine microemulsion can be obtained.

[0146] Comparative Example 14. 20% compound A4·flubenzimine dispersible concentrate

[0147] According to the formulation requirements, 10% of compound A4, 10% of flubenzimine, 30% of methyl oleate, 10% of agricultural emulsifier 1601, 10% of D800 are stirred and mixed evenly, and 20% compound A4·flubenzimine dispersible concentrate can be obtained.

[0148] Example 14. 20% compound A4·flubenzimine dispersible concentrate

[0149] According to the formulation requirements, 10% of compound A4, 10% of flubenzimine, 30% of methyl oleate, 10% of agricultural emulsifier 1601, 10% of D800, 0.5% of antimony trioxide are stirred and mixed evenly, and 20% compound A4·flubenzimine dispersible concentrate can be obtained.

[0150] Comparative Example 15. 20% compound A5·flubenzimine microcapsule suspension

[0151] According to the formulation requirements, 10% of compound A5, 10% of flubenzimine, 20% of S200 are stirred evenly. An aqueous solution containing 10% of YUS-FS3000 is added thereto, and 0.5% of SK-24N is added and stirred to obtain an O / W stable emulsion. The capsule material urea-formaldehyde prepolymer is added thereto to wrap the oil-phase substances, and 20% compound A5·flubenzimine microcapsule suspension can be obtained.

[0152] Example 15. 20% compound A5·flubenzimine microcapsule suspension

[0153] According to the formulation requirements, 10% of compound A5, 10% of flubenzimine, 20% of S200 are stirred evenly. An aqueous solution containing 10% of YUS-FS3000 is added thereto, and 0.5% of antimony trioxide and 0.5% of SK-24N are added and stirred to obtain an O / W stable emulsion. The capsule material urea-formaldehyde prepolymer is added thereto to wrap the oil-phase substances, and 20% compound A5·flubenzimine microcapsule suspension can be obtained.

[0154] Comparative Example 16. 16% compound A6·flubenzimine emulsifiable concentrate

[0155] According to the formulation requirements, 68% of compound A6, 8% of flubenzolate, 10% of agricultural emulsifier 1601, 10% of D800, and S200 is added to make up to 100%. Stir and mix evenly. If necessary, heat and dissolve using a hot water bath to obtain 16% compound A6·flubenzolate emulsifiable concentrate.

[0156] Example 16. 16% compound A6·flubenzolate emulsifiable concentrate

[0157] According to the formulation requirements, 68% of compound A6, 8% of flubenzolate, 10% of agricultural emulsifier 1601, 10% of D800, 0.5% of antimony trioxide, 0.5% of SK-24N, and S200 is added to make up to 100%. Stir and mix evenly. If necessary, heat and dissolve using a hot water bath to obtain 16% compound A6·flubenzolate emulsifiable concentrate.

[0158] Comparative Example 17. 40% compound A7·flubenzolate suspo-emulsion

[0159] According to the formulation requirements, 20% of compound A7, 20% of flubenzolate, 10% of SP27001, 10% of SD-811, 0.1% of xanthan gum, and water is added to make up to 100%. Add them to the mixing tank in sequence and mix. First, carry out coarse crushing and homogenization through high shear, and then pump it into a sand mill for fine grinding to obtain 40% compound A7·flubenzolate suspo-emulsion.

[0160] Example 17. 40% compound A7·flubenzolate suspo-emulsion

[0161] According to the formulation requirements, 20% of compound A7, 20% of flubenzolate, 10% of SP27001, 10% of SD-811, 0.6% of antimony trioxide, 0.6% of SK-24N, 0.1% of xanthan gum, and water is added to make up to 100%. Add them to the mixing tank in sequence and mix. First, carry out coarse crushing and homogenization through high shear, and then pump it into a sand mill for fine grinding to obtain 40% compound A7·flubenzolate suspo-emulsion.

[0162] Comparative Example 18. 20% compound A8·flubenzolate soluble concentrate

[0163] According to the formulation requirements, 10% of compound A8, 10% of flubenzolate, 10% of 14105, 10% of agricultural emulsifier 0201B, and S200 is added to make up to 100%. Stir and mix evenly to obtain 10% compound A8·flubenzolate soluble concentrate.

[0164] Example 18. 20% compound A8·flubenzolate soluble concentrate

[0165] According to the formulation requirements, 10% of compound A8, 10% of pyridalyl, 10% of 14105, 10% of agricultural emulsifier 0201B, 0.2% of antimony trioxide, and S200 is added to make up 100%. Stir and mix evenly to obtain 10% compound A8·pyridalyl soluble concentrate.

[0166] Comparative Example 1: 9.50% compound A9·pyridalyl granule

[0167] According to the formulation requirements, 25% of compound A9, 25% of pyridalyl, 5% of SK-24N, and 8% of diatomaceous earth are mixed to obtain a mother powder, and then 5% of PVA and quartz sand are added and mixed to obtain 50% compound A9·pyridalyl granule with good physical properties.

[0168] Example 1: 9.50% compound A9·pyridalyl granule

[0169] According to the formulation requirements, 25% of compound A9, 25% of pyridalyl, 5% of antimony trioxide, 5% of SK-24N, and 8% of diatomaceous earth are mixed to obtain a mother powder, and then 5% of PVA and quartz sand are added and mixed to obtain 50% compound A9·pyridalyl granule with good physical properties.

[0170] Comparative Example 2: 10.60% compound A10·pyridalyl water dispersible granule

[0171] According to the formulation requirements, 30% of compound A10, 30% of pyridalyl, 2% of Agrilan 755, 3% of SK-24N, 10% of soluble starch, 8% of sodium sulfate, and bentonite is added to make up 100% to obtain 60% compound A·pyridalyl water dispersible granule.

[0172] Example 2: 10.60% compound A10·pyridalyl water dispersible granule

[0173] According to the formulation requirements, 30% of compound A10, 30% of pyridalyl, 2% of Agrilan 755, 3% of SK-24N, 10% of soluble starch, 8% of sodium sulfate, 3% of antimony trioxide, and bentonite is added to make up 100% to obtain 60% compound A·pyridalyl water dispersible granule.

[0174] Comparative Example 3: 20% compound A1 suspension concentrate

[0175] According to the formulation requirements, 20% of compound A1, 10% of SK-20TX, 10% of SP27001, 0.12% of xanthan gum, and water is added to make up 100% are successively added to a mixing tank and mixed. First, it is coarsely pulverized and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain 20% compound A1 suspension concentrate.

[0176] Example 21-1. 20% Suspension Concentrate of Compound A1

[0177] According to the formulation requirements, 20% of Compound A1, 10% of SK-20TX, 10% of SP27001, 0.12% of xanthan gum, 0.3% of antimony trioxide, and the balance of water to 100% are added to the mixing tank in sequence for mixing. First, it is subjected to high-shear for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain 20% suspension concentrate of Compound A1.

[0178] Example 21-2. 20% Suspension Concentrate of Compound A1

[0179] According to the formulation requirements, 20% of Compound A1, 10% of SK-20TX, 10% of SP27001, 0.12% of xanthan gum, 0.3% of antimony trioxide, 0.3% of SK-24N, and the balance of water to 100% are added to the mixing tank in sequence for mixing. First, it is subjected to high-shear for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain 20% suspension concentrate of Compound A1.

[0180] Comparative Example 22. 30% Suspension Concentrate of Compound A2

[0181] According to the formulation requirements, 15% of Compound A2, 10% of SP-27001, 10% of AMS303, 0.10% of xanthan gum, and the balance of water to 100% are added to the mixing tank in sequence for mixing. First, it is subjected to high-shear for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain 30% suspension concentrate of Compound A2.

[0182] Example 22-1. 30% Suspension Concentrate of Compound A2

[0183] According to the formulation requirements, 15% of Compound A2, 10% of SP-27001, 10% of AMS303, 0.10% of xanthan gum, 0.4% of antimony trioxide, and the balance of water to 100% are added to the mixing tank in sequence for mixing. First, it is subjected to high-shear for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain 30% suspension concentrate of Compound A2.

[0184] Example 22-2. 30% Suspension Concentrate of Compound A2

[0185] According to the formulation requirements, 15% of Compound A2, 10% of SP-27001, 10% of AMS303, 0.10% of xanthan gum, 0.4% of antimony trioxide, 0.4% of SK-24N, and the balance of water to 100% are added to the mixing tank in sequence for mixing. First, it is subjected to high-shear for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain 30% suspension concentrate of Compound A2.

[0186] Comparative Example 2. 35% Compound A3 Suspension Concentrate

[0187] According to the formulation requirements, 35% of Compound A3, 10% of SD-811, 10% of YUS-FS7PG, 0.10% of xanthan gum, and water was added to make up to 100%. They were successively added to a mixing tank for mixing. First, high-shear was carried out for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain 35% Compound A2 suspension concentrate.

[0188] Example 23-1. 35% Compound A3 Suspension Concentrate

[0189] According to the formulation requirements, 35% of Compound A3, 10% of SD-811, 10% of YUS-FS7PG, 0.10% of xanthan gum, 1% of antimony trioxide, and water was added to make up to 100%. They were successively added to a mixing tank for mixing. First, high-shear was carried out for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain 35% Compound A2 suspension concentrate.

[0190] Example 23-2. 35% Compound A3 Suspension Concentrate

[0191] According to the formulation requirements, 35% of Compound A3, 10% of SD-811, 10% of YUS-FS7PG, 0.10% of xanthan gum, 1% of antimony trioxide, 1% of SK-24N, and water was added to make up to 100%. They were successively added to a mixing tank for mixing. First, high-shear was carried out for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain 35% Compound A2 suspension concentrate.

[0192] Comparative Example 24. 30% Compound A4 Suspension Concentrate

[0193] According to the formulation requirements, 30% of Compound A4, 10% of SD816, 10% of Morwet D500, 0.08% of xanthan gum, and water was added to make up to 100%. They were successively added to a mixing tank for mixing. First, high-shear was carried out for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain 30% Compound A4 suspension concentrate.

[0194] Example 24-1. 30% Compound A4 Suspension Concentrate

[0195] According to the formulation requirements, 30% of Compound A4, 10% of SD816, 10% of Morwet D500, 0.08% of xanthan gum, 2% of antimony trioxide, and water was added to make up to 100%. They were successively added to a mixing tank for mixing. First, high-shear was carried out for coarse crushing and homogenization, and then pumped into a sand mill for fine grinding to obtain 30% Compound A4 suspension concentrate.

[0196] Example 24 - 2. 30% Compound A4 Suspension Concentrate

[0197] According to the formulation requirements, 30% of Compound A4, 10% of SD816, 10% of Morwet D500, 0.08% of xanthan gum, 2% of antimony trioxide, 2% of SK - 24N, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized through high - shear, and then pumped into a sand mill for fine grinding to obtain 30% Compound A4 Suspension Concentrate.

[0198] Comparative Example 25. 40% Compound A5 Suspension Concentrate

[0199] According to the formulation requirements, 40% of Compound A5, 10% of DB08, 10% of SP - SC3, 0.06% of xanthan gum, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized through high - shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A5 Suspension Concentrate.

[0200] Example 25 - 1. 40% Compound A5 Suspension Concentrate

[0201] According to the formulation requirements, 40% of Compound A5, 10% of DB08, 10% of SP - SC3, 0.06% of xanthan gum, 2% of antimony trioxide, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized through high - shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A5 Suspension Concentrate.

[0202] Example 25 - 2. 40% Compound A5 Suspension Concentrate

[0203] According to the formulation requirements, 40% of Compound A5, 10% of DB08, 10% of SP - SC3, 0.06% of xanthan gum, 2% of antimony trioxide, 2% of SK - 24N, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized through high - shear, and then pumped into a sand mill for fine grinding to obtain 40% Compound A5 Suspension Concentrate.

[0204] Comparative Example 26. 20% Compound A6 Suspension Concentrate

[0205] According to the formulation requirements, 20% of Compound A6, 10% of agricultural emulsion 0201B, 10% of SP - SC29, 0.16% of xanthan gum, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized through high - shear, and then pumped into a sand mill for fine grinding to obtain 20% Compound A6 Suspension Concentrate.

[0206] Example 26 - 1. 20% Compound A6 Suspension Concentrate

[0207] According to the formulation requirements, 20% of Compound A6, 10% of agricultural emulsifier 0201B, 10% of SP-SC29, 0.16% of xanthan gum, 4% of antimony trioxide, and water are added to make up to 100%. They are added to the mixing tank in sequence and mixed. First, they are coarsely crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain a 20% suspension of Compound A6.

[0208] Example 26-2. 20% Suspension of Compound A6

[0209] According to the formulation requirements, 20% of Compound A6, 10% of agricultural emulsifier 0201B, 10% of SP-SC29, 0.16% of xanthan gum, 4% of antimony trioxide, 4% of SK-24N, and water are added to make up to 100%. They are added to the mixing tank in sequence and mixed. First, they are coarsely crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain a 20% suspension of Compound A6.

[0210] Comparative Example 27. 40% Suspension of Compound A7

[0211] According to the formulation requirements, 40% of Compound A7, 10% of Emulson 14105, 10% of D800, 0.06% of xanthan gum, 5% of antimony trioxide, 5% of SK-24N, and water are added to make up to 100%. They are added to the mixing tank in sequence and mixed. First, they are coarsely crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of Compound A7.

[0212] Example 27-1. 40% Suspension of Compound A7

[0213] According to the formulation requirements, 40% of Compound A7, 10% of Emulson 14105, 10% of D800, 0.06% of xanthan gum, 5% of antimony trioxide, and water are added to make up to 100%. They are added to the mixing tank in sequence and mixed. First, they are coarsely crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of Compound A7.

[0214] Example 27-2. 40% Suspension of Compound A7

[0215] According to the formulation requirements, 40% of Compound A7, 10% of Emulson 14105, 10% of D800, 0.06% of xanthan gum, 5% of antimony trioxide, 5% of SK-24N, and water are added to make up to 100%. They are added to the mixing tank in sequence and mixed. First, they are coarsely crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of Compound A7.

[0216] Comparative Example 28. 40% Suspension of Compound A8

[0217] According to the formulation requirements, 40% of compound A8, 10% of SK-20TX, 10% of YUS-FS3000, 0.04% of xanthan gum, and water are added up to 100%. They are added into the mixing tank in sequence for mixing. First, they are roughly crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of compound A8.

[0218] Example 28-1. 40% suspension of compound A8

[0219] According to the formulation requirements, 40% of compound A8, 10% of SK-20TX, 10% of YUS-FS3000, 0.04% of xanthan gum, 2% of antimony trioxide, and water are added up to 100%. They are added into the mixing tank in sequence for mixing. First, they are roughly crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of compound A8.

[0220] Example 28-2. 40% suspension of compound A8

[0221] According to the formulation requirements, 40% of compound A8, 10% of SK-20TX, 10% of YUS-FS3000, 0.04% of xanthan gum, 2% of antimony trioxide, 2% of SK-24N, and water are added up to 100%. They are added into the mixing tank in sequence for mixing. First, they are roughly crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of compound A8.

[0222] Comparative Example 29. 40% suspension of compound A9

[0223] According to the formulation requirements, 40% of compound A9, 10% of XA265, 10% of Agrilan 755, 0.04% of xanthan gum, and water are added up to 100%. They are added into the mixing tank in sequence for mixing. First, they are roughly crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of compound A9.

[0224] Example 29-1. 40% suspension of compound A9

[0225] According to the formulation requirements, 40% of compound A9, 10% of XA265, 10% of Agrilan 755, 0.04% of xanthan gum, 2% of antimony trioxide, and water are added up to 100%. They are added into the mixing tank in sequence for mixing. First, they are roughly crushed and homogenized by high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of compound A9.

[0226] Example 29-2. 40% suspension of compound A9

[0227] According to the formulation requirements, 40% of compound A9, 10% of XA265, 10% of Agrilan 755, 0.04% of xanthan gum, 2% of antimony trioxide, 2% of SK-24N, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized through high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of compound A9.

[0228] Comparative Example 30. 40% suspension of compound A10

[0229] According to the formulation requirements, 40% of compound A10, 10% of SP-27001, 10% of AMS303, 0.10% of xanthan gum, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized through high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of compound A10.

[0230] Example 30-1. 40% suspension of compound A10

[0231] According to the formulation requirements, 40% of compound A10, 10% of SP-27001, 10% of AMS303, 0.10% of xanthan gum, 1% of antimony trioxide, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized through high

[0232] shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of compound A10.

[0233] Example 30-2. 40% suspension of compound A10

[0234] According to the formulation requirements, 40% of compound A10, 10% of SP-27001, 10% of AMS303, 0.10% of xanthan gum, 1% of antimony trioxide, 1% of SK-24N, and water are added up to 100%. They are added to the mixing tank in sequence for mixing. First, they are coarsely crushed and homogenized through high shear, and then pumped into a sand mill for fine grinding to obtain a 40% suspension of compound A10.

[0235] The suspension rate of the above-mentioned examples was measured according to the method mentioned in the national standard GB / T 14825. The specific method was to accurately weigh 1.5 g of the preparation sample (accurate to 0.0002 g) and perform the measurement according to "Method 1" in GB / T 14825. The remaining 25 mL of the suspension and the precipitate were transferred into a 100 mL volumetric flask, washed twice with 10 mL of methanol each time, and the washing solution was incorporated into the volumetric flask. Then, it was made up to the mark with methanol, degassed in an ultrasonic bath for 10 min, and cooled until the liquid level returned to the scale. After centrifugal separation, the supernatant was taken, and the mass of the active ingredient was determined by high-performance liquid chromatography. The suspension rate X was calculated (see Table 2). The formula for the suspension rate is as follows:

[0236]

[0237] In the formula, m1 is the mass of the active ingredient in the sample taken for preparing the suspension, in g;

[0238] m2 is the mass of the active ingredient in the 25 mL of the suspension remaining at the bottom of the measuring cylinder, in g;

[0239] Table 1 Results of suspension rate measurement

[0240]

[0241]

[0242] As can be seen from Table 1, there are problems such as a decrease in the suspension rate when the active ingredient is diluted and applied in water. Antimony trioxide was added separately in the comparative examples, and it was found that the suspension rate was significantly improved. Especially under the condition of adding the lignosulfonate auxiliary agent SK-24N and compounding it with antimony trioxide, that is, under the compounding of a suitable wetting and dispersing agent, the suspension rate was greatly improved, and this problem could be effectively solved, which could effectively solve the compatibility problem in the dilution and application link of pesticide formulation mixing and bring practical application significance.

Claims

1. A miticide preparation, comprising an active ingredient and agriculturally acceptable auxiliaries and carriers, characterized in that: The active ingredient is active component A and / or active component B, and the active ingredient accounts for 1%-70% of the weight of the preparation. Among them, active component A is selected from compounds A1-A10, active component B is pyridalyl, and the weight ratio of active component A to active component B is 50:1-1:50; the active component A is one or more of the compounds with the following structures:

2. The acaricide preparation according to claim 1, characterized in that: The pesticide preparation is a granule, wettable powder, water dispersible granule, suspension, dispersible oil suspension, microcapsule suspension, suspension emulsion, soluble solution, emulsion in water, microemulsion, emulsifiable concentrate, dry suspension, water dispersible tablet, soluble granule, soluble powder, emulsifiable powder or emulsifiable granule.

3. The acaricide preparation according to claim 1 or 2, characterized in that: The auxiliary agent is one or more of a wetting and dispersing agent, a solvent, an oil base, a carrier, a capsule material, and a suspending agent.

4. The acaricide preparation according to claim 3, characterized in that: The suspending agent is antimony trioxide, and the addition amount is 0%-5% of the quality of the preparation.

5. The acaricide preparation according to claim 4, characterized in that: The auxiliary agent is a wetting and dispersing agent and a suspending agent and one or more of a solvent, an oil base, a carrier, and a capsule material.

6. The acaricide formulation according to claim 3, characterized in that: The wetting and dispersing agent is one or more of lignosulfonate, polyacrylate, polycarboxylate, carboxylate, carboxylic acid polymer copolymer, sulfonate, sulfate, phosphate, aryl ether phosphate, gemini-like amphiphilic surfactant complex, compound auxiliary agent of polyacrylate copolymer, special structure polymer surfactant, EO / PO block polyether, polymer, block copolymer, single comb polymer, sodium salt of alkyl naphthalene sulfonic acid condensate + block copolymer, agricultural emulsion T-20, agricultural emulsion 0201B, agricultural emulsion 0203B, agricultural emulsion 1601, naphthalene sulfonate formaldehyde condensate, sodium salt of methyl naphthalene sulfonate formaldehyde condensate, polyvinyl alcohol, chitosan.

7. The acaricide preparation according to claim 6, characterized in that: The wetting and dispersing agent is a mixture of lignosulfonate and one or more of the following substances; among them, the following substances are polyacrylate, polycarboxylate, carboxylate, carboxylic acid polymer copolymer, sulfonate, sulfate, phosphate, aryl ether phosphate, gemini-like amphiphilic surfactant complex, compound auxiliary agent of polyacrylate copolymer, special structure polymer surfactant, EO / PO block polyether, polymer, block copolymer, single comb polymer, sodium salt of alkyl naphthalene sulfonic acid condensate + block copolymer, agricultural emulsion T-20, agricultural emulsion 0201B, agricultural emulsion 0203B, agricultural emulsion 1601, naphthalene sulfonate formaldehyde condensate, sodium salt of methyl naphthalene sulfonate formaldehyde condensate, polyvinyl alcohol, chitosan.

8. The acaricide preparation according to any one of claims 3-7, characterized in that: When the wetting and dispersing agent contains lignosulfonate, a suspending agent is added, and the mass ratio of the suspending agent to the wetting and dispersing agent is 1:

1.

9. The acaricide preparation according to claim 1, characterized in that, The application of the preparation in the field of agricultural acaricides.

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