Cervical sampler, operation method thereof and suite

Abstract

The invention discloses a cervix sampler, an operation method thereof and a kit, the sampler comprises a shell, the shell comprises a shell side wall and a closed shell far-end wall, the shell side wall comprises a first notch, and the first notch is arranged close to the shell far-end wall; the sampling brush is configured to be accommodated in the shell, and at least one part of the sampling brush is exposed to the position of the first notch in at least one use state; the shaft comprises a shaft far end and a shaft near end, the shaft far end is connected with the sampling brush, the shaft near end further comprises an operator, and the operator drives the shaft and the sampling brush to rotate in the circumferential direction under the operation of external force, so that the sampling brush makes contact with a target sample near the first notch in the using state, and friction force is generated to obtain biological tissue. The sampler can be conveniently placed at a target position and sample tissue can be conveniently obtained. The collected biological tissues can be cervical cells, and can be used for double detection (PAP / HPV Co-Testing) of cervical smear (PAP) and human papilloma virus (HPV), and can be used for screening cervical cancer.

Description

Technical Field

[0001] The present invention relates to the technical field of cervical medical products, and in particular to a cervical sampler, an operating method thereof and a kit. Background Art

[0002] In the prior art, cervical sampling products are inconvenient to use. Sample collection requires special medical facilities, the sample collection experience is poor, samples are easily contaminated, and the collected samples are difficult to collect very conveniently. Summary of the invention

[0003] In view of this, the technical problem to be solved by the present invention is to provide a new cervical sampler to solve the problems that the existing cervical sampler has poor practical experience and is difficult to collect samples.

[0004] The present invention solves the above technical problems and provides a cervical sampler in one aspect, comprising:

[0005] The shell comprises a shell side wall and a closed shell distal wall, the shell side wall comprises a first notch, and the first notch is arranged near the shell distal wall; the sampling brush is configured to be accommodated in the shell and in at least one use state, at least a portion of the sampling brush is exposed to the position where the first notch is located; the shaft comprises a shaft distal end and a shaft proximal end, the shaft distal end is connected to the sampling brush, and the shaft proximal end also comprises an operator, the operator drives the shaft and the sampling brush to rotate circumferentially under external force operation, so that the sampling brush contacts the target sample near the first notch in the use state and generates friction to obtain biological tissue.

[0006] Another aspect of the present application provides an operating method of a cervical sampler, comprising:

[0007] A sampler according to any of the aforementioned embodiments is provided, wherein the retaining wall is set to a first use state; at least a portion of the sampler is placed at a target sample position; under the action of an external force, the retaining wall is set to a second use state, so that the sampling brush is exposed to the position where the first notch is located; under the action of the external force, the operator is rotated at least one circle, so that the operator drives the shaft and the sampling brush to rotate circumferentially, and the sampling brush contacts the target sample near the first notch and generates friction to obtain biological tissue.

[0008] Another aspect of the present application provides a cervical sampler kit, comprising:

[0009] The sampler of any of the preceding embodiments;

[0010] A container is configured and sized to accommodate at least the sampling brush therein.

[0011] Another aspect of the present application provides a self-operable cervical cancer cell sampler, comprising:

[0012] A shaft, including a distal end of the shaft and a proximal end of the shaft; a sampling brush for obtaining a sample; a circumferentially rotatable operator, the outer wall of which is provided with anti-slip lines, and when the operator rotates under an external force, the operator drives the shaft and the sampling brush to rotate in the same direction; a housing, including a housing side wall and a closed distal wall of the housing, the housing side wall includes a first notch, and the first notch is arranged near the distal wall of the housing; the housing side wall is configured to include a second notch, and the position of the second notch corresponds to the position of the operator, so that at least a part of the operator is exposed at the position where the second notch is located; an auxiliary plate fixedly connected to the housing; a retaining wall slidably connected to the auxiliary plate, so that the retaining wall realizes axial movement relative to the housing; the size and shape of the retaining wall are configured to at least cover the first notch, and the retaining wall is arranged to switch between a first use state and a second use state under an external force; the retaining wall is further configured to include a window, and the position of the window corresponds to the operator; wherein, the sampling brush is configured to be accommodated in the housing and at least in one use state, at least a part of the sampling brush is exposed at the position where the first notch is located; in the first use state, the retaining wall covers the first notch; in the second use state, the retaining wall is away from the first notch, so that the sampling brush is exposed at the position where the first notch is located; and at least a part of the operator is exposed from the window; wherein, the distal end of the shaft is connected to the sampling brush, and the proximal end of the shaft is connected to the operator; wherein, the operator drives the shaft and the sampling brush to rotate circumferentially for 5 turns under an external operation, so that the sampling brush contacts the target sample near the first notch in the use state and generates friction to obtain cervical cells.

[0013] Other example embodiments are discussed herein.

[0014] The present invention has many advantages. In some embodiments, the sampler provided by the present invention is characterized in that it can be easily pushed into the vaginal and cervical target positions; in some embodiments, the sampler provided by the present invention has the advantage that the sampling brush can obtain samples more easily and accurately; in some embodiments, the sampler provided by the present invention is characterized in that it is easier to push forward or pull backward; in some embodiments, the sampler provided by the present invention adopts an ergonomic design, has the advantages that samples can be collected more easily and it is easy to operate, is suitable for self-operation by the person to be sampled, and does not require additional medical training. In some embodiments, the biological tissue collected by the sampling device provided by the present invention is cervical cells, especially including those for dual detection of cervical smear (PAP) and human papillomavirus (HPV) (PAP / HPV Co-Testing), and is used for cervical cancer screening. The cervical sampler of the present application is suitable for use in medical places and is also suitable for self-use by the person to be sampled in non-medical places such as residences (for example, residences), making the sample collection process more flexible, better protecting the privacy and usage experience of the person to be sampled. The cervical sampler of the present application makes it easier to obtain only the required cervical cells during the sampling process, while avoiding obtaining other tissues or mucus, avoiding sample impurity or contamination, and making the screening result of cervical cancer more accurate. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 is an exploded schematic view of the structure of the cervical sampler according to an embodiment of the present invention;

[0016] Figure 2 is Figure 1 a schematic view of the shown embodiment in the first use state;

[0017] Figure 3 is Figure 1 a schematic view of the shown embodiment in the second use state;

[0018] Figure 4 is a partial structural schematic view of the sampling brush of one of the embodiments. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0019] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention clearer and more understandable, the present invention will be further described in detail below with reference to the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0020] In the present invention, the relative positions and directions such as above, below, top, bottom, inside and outside of the container are defined with reference to the state in which the cervical sampler is placed during normal use as the reference state.

[0021] In the present invention, the "outer shell" is at least a part of the outermost structure of the sampler, which is used to protect the content and provide a rigid shape for the sampler.

[0022] In the present invention, the "axial direction" refers to the direction of the axis of the cylinder in which the outer shell is located with the outer shell as a reference. In this application, the axial direction or the axial direction of the sampler refers to the same direction.

[0023] In this application, the "circumferential direction" refers to the circumferential direction of the cylinder in which the outer shell is located with the outer shell as a reference.

[0024] In this application, the "proximal end and distal end" are referenced based on the state of the sampler during use. The end closer to the operator's hand is the proximal end, and the opposite end away from the operator's hand is the distal end.

[0025] The cervical sampler of this application can also be used for sampling vaginal biological tissues.

[0026] In the present invention, "comprising" means including the following elements, but does not exclude other elements.

[0027] One aspect of this application provides a cervical sampler, comprising:

[0028] An outer shell, including an outer shell side wall and a closed outer shell distal wall. The outer shell side wall includes a first notch, and the first notch is provided near the outer shell distal wall; a sampling brush, which is configured to be accommodated in the outer shell and, in at least one use state, at least a part of the sampling brush is exposed at the position where the first notch is located; a shaft, including a shaft distal end and a shaft proximal end. The shaft distal end is connected to the sampling brush, and the shaft proximal end further includes an operator. The operator drives the shaft and the sampling brush to rotate circumferentially under an external force operation, so that the sampling brush contacts the target sample near the first notch in the use state and generates a frictional force to obtain biological tissue. The closed outer shell distal wall makes it easier for the sampler to move forward in the vagina under a thrust force. The sampling brush is also blocked during the movement into the vagina and will not hinder the movement, so the use experience of the sampling brush is better.

[0029] In at least one embodiment, the sampler further includes a retaining wall. The size and shape of the retaining wall are configured to at least cover the first notch. The retaining wall is arranged to switch between a first use state and a second use state under an external force; in the first use state, the retaining wall covers the first notch; in the second use state, the retaining wall is away from the first notch, so that the sampling brush is exposed at the position where the first notch is located. The sampling brush is exposed only after the sampler reaches the cervical target position, making the collected sample more accurate.

[0030] In at least one embodiment, the retaining wall of the sampler is arranged to move axially along the outer shell side wall.

[0031] In at least one embodiment, the baffle wall of the sampler is arranged to slide circumferentially along the side wall of the outer shell.

[0032] In at least one embodiment, the baffle wall of the sampler is configured to further include a protrusion. When the protrusion is operated by an external force, the baffle wall realizes the switching between the first use state and the second use state.

[0033] In at least one embodiment, the operator of the sampler is a rotary converter. The outer wall of the rotary converter is provided with anti-slip lines. When the rotary converter rotates under the action of an external force, the operator drives the shaft so that the sampling brush rotates in the same direction. In one embodiment, the rotary converter is a dial-type rotary converter.

[0034] In at least one embodiment, the side wall of the outer shell of the sampler is configured to include a second notch. The position of the second notch corresponds to the position of the operator, so that at least a part of the operator is exposed at the position where the second notch is located; the baffle wall is configured to further include a window. When the baffle wall is in the second use state, the position of the window corresponds to the operator, so that at least a part of the operator is exposed.

[0035] In at least one embodiment, a boosting wing is further provided at the proximal end of the baffle wall of the sampler, which is used to apply an axial thrust or pull force to the baffle wall through the boosting wing to realize the switching between the first use state and the second use state.

[0036] In at least one embodiment, a base is further provided at the proximal end of the outer shell of the sampler. One side of the base is rotatably connected to the proximal end of the shaft.

[0037] In at least one embodiment, the other side of the base of the sampler is configured to include a handle, which is used to apply an axial thrust or pull force to the sampler to insert or extract the sampler from the vagina.

[0038] In at least one embodiment, the distal end wall of the outer shell of the sampler is approximately arched.

[0039] In at least one embodiment, the sampling brush of the sampler is detachably connected to the distal end of the shaft. After the sampler completes sample collection, the entire sampling brush is removed and placed in a sample collection container, making it very fast and easy to obtain samples.

[0040] In at least one embodiment, the sampler further includes an auxiliary plate, which is fixedly connected to the outer shell; the auxiliary plate is slidably connected to the baffle wall, so that the baffle wall realizes axial movement relative to the outer shell.

[0041] In at least one embodiment, the biological tissue collected by the sampler is cervical cells. The cervical cells particularly include those for dual detection of Papanicolaou smear (PAP) and human papillomavirus (HPV) (PAP / HPV Co-Testing) and are used for cervical cancer screening.

[0042] Another aspect of the present application provides a method for operating a cervical sampler, including:

[0043] Providing the sampler of any of the foregoing embodiments, with the barrier wall set to the first use state; placing at least a part of the sampler at the target sample position; under an external force, setting the barrier wall to the second use state so that the sampling brush is exposed at the position where the first notch is located; rotating the operator at least one full turn under an external force, causing the operator to drive the shaft and the sampling brush to rotate circumferentially, and the sampling brush obtains biological tissue by contacting the target sample near the first notch and generating frictional force.

[0044] In at least one embodiment, the operation method further includes: setting the barrier wall to the first use state again, dragging the handle to withdraw the sampler from the vagina; setting the barrier wall to the second use state again, exposing the sampling brush from the first notch, and disassembling the sampling brush from the distal end of the shaft to obtain the collected biological tissue. In at least one embodiment, the operator rotates at least 5 turns to collect cervical cells.

[0045] Yet another aspect of the present application provides a cervical sampler kit, including:

[0046] The sampler of any of the foregoing embodiments;

[0047] A container, the size of the container being configured to accommodate at least the sampling brush therein.

[0048] In at least one embodiment, the kit further includes auxiliary tools, and the auxiliary tools are any one or more of lubricants, tweezers, and biological tissue preservation solutions. In one embodiment, the lubricant is applied to the distal wall of the outer shell to make it easy to push the sampler into the target position in the vagina; the biological tissue preservation solution is pre-placed in the container; tweezers are used to assist in disassembling the sampling brush including the sample and placing it in the container.

[0049] Another aspect of the present application provides an operable cervical cancer cell sampler, which includes: a shaft including a distal end and a proximal end; a sampling brush for obtaining a sample; a circumferentially rotatable operator with anti-slip patterns on the outer wall, when the operator rotates under an external force, the operator drives the shaft and the sampling brush to rotate in the same direction; a housing including a housing side wall and a closed distal wall of the housing, the housing side wall includes a first notch provided near the distal wall of the housing; the housing side wall is configured to include a second notch, and the position of the second notch corresponds to the position of the operator, so that at least a part of the operator is exposed at the position where the second notch is located; an auxiliary plate fixedly connected to the housing; a retaining wall slidably connected to the auxiliary plate to enable the retaining wall to move axially relative to the housing; the size and shape of the retaining wall are configured to at least cover the first notch, and the retaining wall is arranged to switch between a first use state and a second use state under an external force; the retaining wall is further configured to include a window, and the position of the window corresponds to the operator; wherein, the sampling brush is configured to be accommodated in the housing and at least in one use state, at least a part of the sampling brush is exposed at the position where the first notch is located; in the first use state, the retaining wall covers the first notch; in the second use state, the retaining wall is away from the first notch, so that the sampling brush is exposed at the position where the first notch is located; and at least a part of the operator is exposed from the window; wherein, the distal end of the shaft is connected to the sampling brush, and the proximal end of the shaft is connected to the operator; wherein, the operator drives the shaft and the sampling brush to rotate circumferentially for 5 turns under an external operation, so that the sampling brush contacts the target sample near the first notch in the use state and generates friction to obtain cervical cells.

[0050] The following further describes various aspects of the present invention with reference to the accompanying drawings:

[0051] As Figure 1Exploded schematic view of the structure of the exemplary cervical sampler 100; wherein, the cervical sampler 100 includes a housing 1, a retaining wall 2, a shaft 10, a sampling brush 5, a base 30, a handle 13, and an auxiliary plate 8; among them, the housing 1 includes a housing side wall 26 and a closed housing distal wall 25, the housing side wall 26 is generally in an arc-shaped surface as a whole, and the housing distal wall 25 is in a circular arch shape; the housing 1 has a first notch 16 and a second notch 27, the first notch 16 is provided at the distal end of the housing 1, and the second notch 27 is provided at the proximal end of the housing 1; a gasket ring 20 is provided on the inner wall of the housing side wall 26, the outer diameter of the gasket ring 20 is equivalent to the inner diameter of the corresponding position of the housing 1, and the center of the gasket ring 20 is a through hole 21 for the shaft 10 to pass through the gasket ring 20 and limit the position of the shaft 10 within the housing 1. A plurality of bayonets 19 are provided on the inner side of the edge of the housing side wall 26, and the inner side of the edge of the auxiliary plate 8 is provided with a corresponding number of buckles 18 as the bayonets 19. After the buckles 18 are combined with the bayonets 19, the auxiliary plate 8 is combined with the housing side wall 26 to form a generally cylindrical body; a flange 17 is provided on the top of the auxiliary plate 8, and a protrusion 7 is provided at the proximal end of the retaining wall 2. The space formed at the bottom of the protrusion 7, when the flange 17 is embedded in the space formed at the bottom of the protrusion 7, the auxiliary plate 8 and the retaining wall 2 form an integral body in the vertical direction. The flange 17 also forms an axial sliding track of the retaining wall 2 relative to the auxiliary plate 8, so that the retaining wall 2 can move forward or backward along the axis of the housing 1; the retaining wall 2 is configured to further include front and rear indicating arrows 14. When an external force drives the protrusion 7 according to the front and rear indicating arrows 14, the retaining wall 2 moves forward or backward along the housing 1. The shaft 10 includes a shaft proximal end and a shaft distal end. An operator 3 is fixedly provided at the shaft proximal end, and then the shaft proximal end forms a rotatable shaft connection with the base 30. Specifically, the base 30 is configured to include a shaft hole 22, and the shaft proximal end is inserted into the shaft hole 22 to form a rotatable shaft connection with the base 30; the shaft distal end is detachably connected to the sampling brush 5. The sampling brush 5 includes bristles 12, a shaft 11 for connecting the brush head, and a connector 6; the connector 6 is inserted into the shaft distal end of the shaft 10, that is, forms a connection with the shaft 10, and a certain external force needs to be applied to separate the connector 6 from the shaft 10. The outer shape of the operator 3 is a cylinder, and anti-slip patterns are provided on the outer wall of the operator 3. The position of the operator 3 corresponds to the position of the second notch 27 of the housing 1, and the position of the sampling brush 5 corresponds to the position of the first notch 16 of the housing 1. When an external force acts on the operator 3 to rotate it circumferentially, the operator 3 drives the shaft 10 and the sampling brush 5 to rotate in the same direction, and the bristles 12 form a frictional force with the cervical wall and obtain cells on the inner wall of the cervix. A clockwise or counterclockwise indicating arrow 15 is also provided at the proximal end of the retaining wall 2 for indicating the rotation direction of the operator 3. A window 9 is further included at the proximal end of the retaining wall 2; a pair of assisting wings 4 are also provided at the proximal end of the retaining wall 2, and the assisting wings 4 are provided on both sides of the proximal end of the retaining wall 2. The assisting wings 4 have two force-receiving surfaces, one force-receiving surface makes it convenient to apply a thrust force, and one force-receiving surface makes it convenient to apply a pulling force, so as to switch the retaining wall between the first use state and the second use state.The proximal end of the sampler 100 further includes a handle 13, which is connected to the sampler through a base 30. The handle 13 is used to push the entire sampler forward or pull it backward as a whole, so that the sampler is pushed in or pulled out of the vagina.

[0052] In one embodiment, during the process of rotating the manipulator 3 to obtain cervical cells, the manipulator 3 is rotated at least 5 turns.

[0053] Figure 2 FIG. 7 is a schematic diagram of the cervical sampler 100 in the first use state. The first use state is the state of the sampler before being pushed into the vagina and during the process of being pushed into the vagina, as well as the state during the process of pulling out the sampler from the vagina after completing the biological tissue collection; the sampler 100 includes a housing 1, and above the housing 1 is a retaining wall 2. The housing 1 and the retaining wall 2 form a generally smooth cylindrical shape in this first use state, and the retaining wall 2 closes the first notch 16 of the housing 1, so that the sampling brush is closed inside the retaining wall 2, and it also makes the sampler enter the vagina more smoothly. To make the sampler enter the vagina more smoothly, a lubricant can also be applied to the outside of the housing 1. After the sampler completes the sample collection, the sampler is switched back to the first use state and then taken out of the vagina to avoid contamination of the sample during the extraction process and affecting the test results.

[0054] As Figure 3 FIG. 12 shows a schematic diagram of the cervical sampler 100 in the second use state. The second use state is the state where the sampler 100 is in the vagina and is preparing to or is collecting biological tissue samples. Under the action of the pulling force applied to the protrusion 7, the retaining wall 2 moves proximally along the housing 1, so that the sampler is in the Figure 3 shown state; in this second use state, the sampling brush 5 is exposed from the first notch 16 on the housing. At the same time, the manipulator 3 is also exposed from the window 9 on the retaining wall 2. The operator then circumferentially drives or rotates the manipulator 3 several times, such as 5 times, in the direction indicated by the clockwise or counterclockwise indication arrow 15 through the window 9. The manipulator 3 drives the sampling brush 5 to rotate in the same direction, and the bristles 12 contact and rub the inner wall of the cervix from the space formed by the first notch, so as to collect sample tissues from the inner wall of the cervix. After the sample collection is completed, the sampler is switched back to the Figure 2 shown first use state, and then the sampler is taken out of the vagina.

[0055] As Figure 4The figure shows a partial structural schematic diagram of the connection between the sampling brush and the shaft. As shown in the figure, the sampling brush 5 is connected to the shaft 10 through the shaft 11 for brush head connection and the connector 6, that is, the connector 6 is inserted into the distal end of the shaft 10. After the sampling is completed, the operator uses tweezers to hold the shaft 11 and apply an external force to pull out the connector 6 from the distal end of the shaft 10, then the sampling brush can be removed. Then the whole sampling brush is placed into the sample collection container and immersed in the biological tissue preservation solution in the container, waiting for the next step of laboratory testing.

[0056] The cervical sampler of the present application adopts an ergonomic design, which is suitable not only for medical staff to use, but also for the self-operation of the sampled person. The cervical sampler of the present application is suitable for use in medical places, and also suitable for self-use by the sampled person in non-medical places such as residences, making the sample collection process more flexible and protecting the privacy and usage experience of the sampled person.

[0057] The preferred embodiments of the present invention have been described above with reference to the accompanying drawings, but this does not limit the scope of the rights of the present invention. Those skilled in the art can implement the present invention in various variant schemes without departing from the scope and essence of the present invention. For example, the features of one embodiment can be used in another embodiment to obtain another embodiment. Any modification, equivalent replacement, and improvement made within the technical concept of the present invention shall fall within the scope of the rights of the present invention.

Claims

1. A cervical sampler, characterized in that Comprising: A housing, including a housing sidewall and a closed housing distal wall, wherein a first notch is provided on the housing sidewall, and the first notch is disposed near the housing distal wall; A sampling brush, which is configured to be accommodated in the housing and at least in one use state, at least a part of the sampling brush is exposed at the position where the first notch is located; A shaft, including a shaft distal end and a shaft proximal end; Wherein, the shaft distal end is connected to the sampling brush, and the shaft proximal end further includes an operator, and the operator drives the shaft and the sampling brush to rotate circumferentially under an external force operation, so that the sampling brush contacts the target sample near the first notch in the use state and generates a frictional force to obtain biological tissue.

2. The sampler according to claim 1, wherein: It further includes a retaining wall, and the size and shape of the retaining wall are configured to at least cover the first notch, and the retaining wall is arranged to switch between a first use state and a second use state under an external force; In the first use state, the retaining wall covers the first notch; In the second use state, the retaining wall is away from the first notch, so that the sampling brush is exposed at the position where the first notch is located.

3. The sampler according to claim 2, wherein: The retaining wall is arranged to move axially along the housing sidewall.

4. The sampler according to claim 2, characterized in that: The retaining wall is arranged to slide circumferentially along the housing sidewall.

5. The sampler according to claim 2, wherein: The retaining wall is configured to further include a protrusion, and when the protrusion is operated by an external force, the retaining wall realizes the switching between the first use state and the second use state.

6. The sampler according to claim 1, wherein: The operator is a rotary converter, and the outer wall of the rotary converter is provided with anti-slip lines. When the rotary converter rotates circumferentially under an external force, the operator drives the shaft, so that the sampling brush rotates in the same direction.

7. The sampler according to claim 1, wherein: The housing sidewall is configured to include a second notch, and the position of the second notch corresponds to the position of the operator, so that at least a part of the operator is exposed at the position where the second notch is located; the retaining wall is configured to further include a window, and when the retaining wall is in the second use state, the position of the window corresponds to the operator, so that at least a part of the operator is exposed.

8. The sampler according to claim 2, wherein: A boosting wing is further provided at the proximal end of the retaining wall, and is used to apply an axial thrust or pull force to the retaining wall through the boosting wing, so that the retaining wall realizes the switching between the first use state and the second use state.

9. The sampler according to claim 1, characterized in that: A base is further provided at the proximal end of the housing, and one side of the base is rotatably connected to the shaft proximal end.

10. The sampler according to claim 9, characterized in that: The other side of the base is configured to include a handle, and the handle is used to apply an axial thrust or pull force to the sampler, so that the sampler is inserted into or withdrawn from the vagina.

11. The sampler according to claim 1, characterized in that: The housing distal wall is approximately arched.

12. The sampler according to claim 1, characterized in that: The sampling brush and the shaft distal end are detachably connected.

13. The sampler according to claim 2, characterized in that: It further includes an auxiliary plate, and the auxiliary plate is fixedly connected to the housing; the auxiliary plate is slidably connected to the retaining wall, so that the retaining wall realizes axial movement relative to the housing.

14. The sampler according to claim 1, wherein: The biological tissue is cervical cells.

15. An operation method of a cervical sampler, including: Providing the sampler according to any one of claims 1-14, and setting the retaining wall to the first use state; Placing at least a part of the sampler at the target sample position; Under the action of an external force, the retaining wall is set to a second use state, so that the sampling brush is exposed at the position where the first notch is located; Under the action of an external force, the operator is rotated at least one full turn, so that the operator drives the shaft and the sampling brush to rotate circumferentially. The sampling brush contacts the target sample near the first notch and generates frictional force to obtain biological tissue.

16. The operation method according to claim 15, further comprising: Setting the retaining wall to the first use state again, and dragging the handle to withdraw the sampler from the vagina; Setting the retaining wall to the second use state again, exposing the sampling brush from the first notch, and disassembling the sampling brush from the distal end of the shaft to obtain the collected biological tissue.

17. The operation method according to claim 15, characterized in that: The operator rotates at least 5 turns to collect cervical cells.

18. A cervical sampler kit, characterized in that Comprising: The sampler according to any one of claims 1-14; A container, the size of which is configured to accommodate at least the sampling brush therein.

19. The kit according to claim 18, wherein: It further includes auxiliary tools, and the auxiliary tools are any one or more of lubricants, tweezers, and biological tissue preservation solutions.

20. An operable cervical cancer cell sampler, characterized in that Comprising: A shaft, including a distal end of the shaft and a proximal end of the shaft; A sampling brush for obtaining samples; A circumferentially rotatable operator, the outer wall of which is provided with anti-slip lines. When the operator rotates under the action of an external force, the operator drives the shaft and the sampling brush to rotate in the same direction; A housing, including a housing side wall and a closed distal wall of the housing. The housing side wall includes a first notch, and the first notch is arranged near the distal wall of the housing; The housing side wall is configured to include a second notch, and the position of the second notch corresponds to the position of the operator, so that at least a part of the operator is exposed at the position where the second notch is located; An auxiliary plate fixedly connected to the housing; A retaining wall slidably connected to the auxiliary plate, so that the retaining wall realizes axial movement relative to the housing; the size and shape of the retaining wall are configured to at least cover the first notch, and the retaining wall is set to switch between a first use state and a second use state under the action of an external force; the retaining wall is further configured to include a window, and the position of the window corresponds to the operator; Wherein, the sampling brush is configured to be accommodated in the housing and in at least one use state, at least a part of the sampling brush is exposed at the position where the first notch is located; In the first use state, the retaining wall covers the first notch; In the second use state, the retaining wall is away from the first notch, so that the sampling brush is exposed at the position where the first notch is located; and at least a part of the operator is exposed from the window; Wherein, the distal end of the shaft is connected to the sampling brush, and the proximal end of the shaft is connected to the operator; Wherein, the operator drives the shaft and the sampling brush to rotate circumferentially 5 turns under the operation of an external force, so that the sampling brush contacts the target sample near the first notch in the use state and generates frictional force to obtain cervical cells.

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