Skin care product containing tea tree oil compound bacteriostatic essential oil and preparation method and device thereof

Abstract

The invention relates to a skin care product containing tea tree oil compound bacteriostatic essential oil and a preparation method and device thereof, the skin care product is specifically a skin care gel patch, and comprises a silica gel layer and a microneedle base material; the silica gel layer is prepared from the following components in percentage by weight: 6 to 10 percent of salvianolic acid, 6 to 12 percent of sodium hyaluronate, 8 to 12 percent of tea tree oil compound bacteriostatic essential oil and 70 to 80 percent of organic silicon polymer; the tea tree oil compound bacteriostatic essential oil comprises the following components: tea tree oil, citronella essential oil and clove essential oil. According to the invention, the tea tree oil compound bacteriostatic essential oil is applied to the skin-care gel patch, and efficacy test verification shows that the skin-care gel patch provided by the invention has an exact inhibition effect on acne pathogenic bacteria-propionibacterium acnes, and in addition, the skin-care gel patch can also significantly inhibit skin scar cell proliferation and effectively remove scars.

Description

Technical Field

[0001] The invention belongs to the technical field of external skin care products, and in particular relates to a skin care product containing tea tree oil compound antibacterial essential oil and a preparation method and a device thereof. Background Art

[0002] Acne, also known as pimples, is a chronic inflammatory disease of the sebaceous glands of the hair follicles caused by a combination of factors. It is closely related to factors such as bacterial infection, inflammatory response, incomplete cleaning leading to blocked hair follicles and excessive sebum secretion. It is prone to recurrence. In severe cases, pigmented red marks or concave scars are left after healing. Acne removal and anti-scar treatment have always been important research topics in the field of skin care products.

[0003] Essential oil products extracted from natural plants are widely used in the field of skin care products. Tea tree essential oil is extracted from the leaves and twigs of the Myrtaceae plant Melaleuca alternifolia. Its main components include terpenes, such as eucalyptol and pinolene. Its common effects include antibacterial, anti-inflammatory and soothing. Citronella essential oil is extracted from the leaves and stems of citronella. Its main components include citronellal, citronellol, geraniol, etc. Its common effects include insect repellent, antibacterial and soothing. Clove essential oil is extracted from the buds of cloves. Its main component is eugenol. Its common effects include antibacterial, anti-inflammatory and analgesic.

[0004] It can be seen that plant essential oils all have good antibacterial properties, and antibacterial and anti-inflammatory properties are one of the effects that acne-removing products need to have. Whether the antibacterial properties of tea tree oil, citronella essential oil and clove essential oil have good antibacterial properties against the main pathogenic bacteria of acne-Propionibacterium acnes, and the anti-scar effect of the three combinations, there are few reports in the existing technology. To this end, the present invention is based on the combination of tea tree oil, citronella essential oil and clove essential oil, and proposes a skin care product containing tea tree oil compound antibacterial essential oil and a preparation method and device. Summary of the invention

[0005] The purpose of the present invention is to provide a skin care product containing tea tree oil compound antibacterial essential oil and a preparation method and device in order to solve the above problems.

[0006] The present invention achieves the above-mentioned purpose through the following technical solutions:

[0007] The first aspect of the present invention provides a skin care product containing tea tree oil compound antibacterial essential oil, specifically a skin care gel patch, comprising a silicone gel layer and a microneedle substrate, wherein the silicone gel layer contains 6-10% salvianolic acid, 6-12% sodium hyaluronate, 8-12% tea tree oil compound antibacterial essential oil and 70-80% silicone polymer by weight percentage; the ingredients of the tea tree oil compound antibacterial essential oil include tea tree oil, citronella essential oil and clove essential oil.

[0008] As a further optimized solution of the present invention, the microneedle substrate includes a polyamide textile layer and a microneedle matrix disposed on the polyamide textile layer.

[0009] As a further optimized solution of the present invention, the silicone polymer is a mixture of polydimethylsiloxane and vinyl polydimethylsiloxane.

[0010] As a further optimized solution of the present invention, the compound volume ratio of tea tree oil, citronella essential oil and clove essential oil is 2:0.4 - 1.2:1.

[0011] In the second aspect of the present invention, there is also provided a preparation method of a skin care product containing the tea tree oil compound antibacterial essential oil as described in any one of the above, including the following steps:

[0012] (1) Prepare the tea tree oil compound antibacterial essential oil: Dissolve tea tree oil, citronella essential oil and clove essential oil in ethanol, and stir at 45 - 60 °C for 0.5 - 1 h to obtain the tea tree oil compound antibacterial essential oil;

[0013] (2) According to the formula amount, mix salvianolic acid, sodium hyaluronate, the tea tree oil compound antibacterial essential oil and the silicone polymer, and stir evenly in vacuum to obtain a silicone gel matrix;

[0014] (3) First, send the silicone gel matrix obtained in step (2) into a plasma device for gas filling treatment. After the gas filling treatment is completed, subject the silicone gel matrix to a primary curing treatment and then coat it on a release substrate to obtain a silicone gel layer;

[0015] (4) Cover the microneedle substrate on the side of the silicone gel layer obtained in step (2) that is different from the release substrate. After natural standing, subject the silicone gel matrix to a secondary curing treatment to obtain a skin care gel patch.

[0016] As a further optimized solution, in step (3), the process parameters for gas filling treatment in the plasma device are: set the power to 50 - 100 W, the pressure to 10 - 15 Pa, perform oxygen gas filling treatment for 60 - 120 s, and the oxygen flow rate is 2 - 4 m / s.

[0017] In the third aspect of the present invention, there is also provided a preparation device for implementing the preparation method as described in any one of the above, including a silicone gel matrix preparation tank and an essential oil preparation tank, and further including a plasma gas filling unit whose feeding end is connected to the discharging end of the silicone gel matrix preparation tank through a pumping pipeline. The intake end of the plasma gas filling unit is connected to a gas supply unit, and the gas supply unit supplies oxygen to the plasma gas filling unit to fill the silicone gel matrix. The discharging end of the plasma gas filling unit is connected to an injection unit through a pumping pipeline;

[0018] A forming roller for receiving the silicone gel matrix conveyed by the injection unit;

[0019] A heat conduction circulation unit connected to a forming roller, which supplies heat to a silicone gel matrix for primary curing by the heat conduction circulation unit;

[0020] A release substrate roller for conveying a release substrate, and the forming roller conveys the primary-cured silicone gel matrix onto the release substrate;

[0021] A microneedle substrate roller for conveying a microneedle substrate and covering the side of the silicone gel layer different from the release substrate;

[0022] And a drying unit for secondary curing of the silicone gel matrix.

[0023] As a further optimized solution of the present invention, one end of the drying unit close to the discharge port of the forming roller is connected with a negative pressure air extraction unit through a pipeline, and the other end far from the discharge port of the forming roller is connected with a heater through a pipeline. The liquid inlet end of the heater is connected with the heat conduction circulation unit through a pipeline, and the gas inlet end of the heater is connected with the outlet end of the air supply unit through a pipeline.

[0024] As a further optimized solution of the present invention, the forming roller includes a roller body, limit plates arranged at both ends of the roller body, and a hollow shaft penetrating through the inside of the roller body. Forming molds are oppositely arranged on the outer side of the roller body, and a fine pore net is arranged at the position corresponding to the forming molds on the outer side of the roller body. The diameter of the limit plates near the two forming molds exceeds the diameter of the roller body.

[0025] As a further optimized solution of the present invention, a vibration assembly is arranged on the limit plate. The vibration assembly includes a vibration block sleeved on the hollow shaft and an elastic member arranged on the side of the vibration block corresponding to the forming mold. One end of the elastic member not connected to the vibration block is provided with a fixing block connected to the limit plate.

[0026] Therefore, the beneficial effects of the present invention are as follows:

[0027] (1) The present invention applies the compound antibacterial essential oil prepared by compounding tea tree oil, citronella essential oil and clove essential oil to the silicone gel to make a skin care gel patch. Through comparative experiments, it is found that the tea tree oil compound antibacterial essential oil has good antibacterial effects, and its anti-scar effect is also relatively prominent. And there is a synergistic effect with salvianolic acid in the anti-scar effect, which can significantly inhibit the proliferation of skin scar cells and effectively remove scars.

[0028] (2) In the preparation process of the silicone gel layer of the present invention, a plasma inflation treatment step is added to the silicone gel matrix. Through experimental comparison, it is found that the skin care gel patch made by plasma inflation treatment has good air permeability, which helps to improve the use comfort of the gel patch and also helps to exert the antibacterial, anti-acne and anti-scar effects.

[0029] (3) The present invention further provides a preparation device for a skin care gel patch. Through the design of the device structure, the device can complete the continuous processing of inflating, primary curing, and secondary curing of the silicone gel matrix, and enable the silicone gel matrix to be well compounded in the release substrate and the microneedle substrate. In addition, compared with the traditional process of coating and then cutting, the present invention can reduce the loss rate of the silicone gel matrix and save costs. Description of the Drawings

[0030] Figure 1 is the process flow chart of the preparation of the skin care coagulation patch provided by the present invention;

[0031] Figure 2 is the layout schematic diagram of the preparation device of the skin care gel patch provided by the present invention;

[0032] Figure 3 is the three-dimensional structure schematic diagram of the forming roller provided by the present invention;

[0033] Figure 4 is the cross-sectional structure diagram of the limit plate provided by the present invention.

[0034] In the figure: 1, silicone gel matrix preparation tank; 2, essential oil preparation tank; 3, plasma inflation unit; 4, injection unit; 5, forming roller; 51, roller body; 52, limit plate; 53, hollow shaft; 54, forming die; 55, fine pore net; 56, vibration assembly; 561, vibration block; 562, fixed block; 563, elastic member; 6, release substrate roller; 7, microneedle substrate roller; 8, heat conduction circulation unit; 9, gas supply unit; 10, drying unit; 11, heater; 12, negative pressure air extraction unit. Detailed Embodiments

[0035] The following further describes the present application in detail with reference to the drawings. It is necessary to point out here that the following detailed embodiments are only used to further illustrate the present application and cannot be understood as limiting the protection scope of the present application. Those skilled in the art can make some non-essential improvements and adjustments to the present application based on the above application content.

[0036] The materials and reagents used in the following examples are all commercially available products unless otherwise specified, and the methods used are all conventional methods known to those skilled in the art unless otherwise specified.

[0037] In the following examples:

[0038] The silicone polymer is a mixture of polydimethylsiloxane and vinyl polydimethylsiloxane; among them, the number-average molecular weight of polydimethylsiloxane is 6,000 - 8,000, and the viscosity at 25°C is 7,000 cp; the number-average molecular weight of vinyl polydimethylsiloxane is 60,000 - 80,000, the vinyl content is 4 - 8%, and the viscosity at 25°C is 50,000 cp, but not limited to this.

[0039] Salvianolic acid, specifically Salvianolic Acid C is used, with the CAS number 115841 - 09 - 3 and the molecular formula C 26 H 20 O 10 。

[0040] The microneedle substrate includes a polyamide textile layer and a microneedle matrix provided on the polyamide textile layer.

[0041] The process flow chart for preparing the skin care coagulation patch provided by the present invention is as Figure 1 shown.

[0042] Example 1 Preparation of the silicone gel matrix

[0043] The silicone gel layer in this example, calculated by weight percentage, contains 6 - 10% salvianolic acid, 6 - 12% sodium hyaluronate, 8 - 12% tea tree oil compound antibacterial essential oil, and 70 - 80% silicone polymer; the components of the tea tree oil compound antibacterial essential oil include tea tree oil, citronella essential oil, and clove essential oil, and the compounding volume ratio is 2:0.4 - 1.2:1.

[0044] Dissolve tea tree oil, citronella essential oil, and clove essential oil in ethanol according to the formula amount, and stir at 45°C for 1 h to obtain the tea tree oil compound antibacterial essential oil, or stir at 60°C for 30 min. In this example, the former is used.

[0045] According to the formula amount, mix salvianolic acid, sodium hyaluronate, tea tree oil compound antibacterial essential oil, and silicone polymer, and stir evenly under vacuum to obtain the silicone gel matrix.

[0046] First, to explore the influence of the components and ratios of the silicone gel matrix on its efficacy, within the formula range given above, adjust the components and ratios of the silicone gel matrix according to Table 1, and limit the compounding volume ratio of tea tree oil, citronella essential oil, and clove essential oil in the tea tree oil compound antibacterial essential oil to 2:0.8:1.

[0047] Table 1 Components and ratios of the silicone gel matrix Unit: weight percentage %.

[0048]

[0049]

[0050] According to the components and ratios of the silicone gel matrix given in Table 1, samples A-1 to A-5 and control sample 1-2 were prepared. The following efficacy tests were carried out on the above samples:

[0051] (1) Antibacterial test

[0052] The test bacteria were Propionibacterium acnes ATCC 6919, Staphylococcus aureus ATCC 6538, and Micrococcus luteus ATCC 4698.

[0053] Pick 1-2 colonies of the test bacteria and inoculate them on the LB plate medium. Culture for 24 h under their respective suitable culture conditions, rinse with sterile normal saline, put the rinse solution into a sterile test tube, and use the McFarland turbidity method for turbidity measurement. The turbidity tube needs to be shaken 10-12 times before use. First, make the turbidity reach 3×10 8 / mL, and then dilute it to 10 5 -10 6 / mL for standby.

[0054] Then, dip a sterilized cotton swab into the bacterial liquid, squeeze out the excess bacterial liquid on the tube wall, evenly coat it on the LB plate medium, and sweep around the edge of the petri dish once. Cover the petri dish and dry for 2-3 min. Gently place a sterile steel cup (diameter 6 mm) on the plate medium, add the sample, and place it in an incubator at 37°C for 24 h. It is found that there is no bacterial growth in the petri dish. After continuing to culture at 37°C for 24 h, an inhibition zone is formed. Measure the diameter of the inhibition zone (Propionibacterium acnes is cultured under low oxygen, and Staphylococcus aureus and Micrococcus luteus are cultured under aerobic conditions). For each test bacterium, set 3 groups in parallel, and the antibacterial test results are averaged from the 3 inhibition zone diameter values. In addition, for each test bacterium, set a blank control group without adding the sample, and also set 3 groups in parallel.

[0055] Classification of antibacterial drug sensitivity: An inhibition zone diameter greater than 20 mm indicates high sensitivity, 10-20 mm indicates medium sensitivity, and less than 10 mm indicates drug resistance. The antibacterial test results are shown in Table 2.

[0056] Table 2 Antibacterial test results

[0057]

[0058]

[0059] It can be seen from Table 2 that the silicone gel matrix has a definite inhibitory effect on Propionibacterium acnes, Staphylococcus aureus, and Micrococcus luteus.

[0060] For Staphylococcus aureus and Micrococcus luteus, on the premise of a certain dosage of the compound antibacterial essential oil of sodium hyaluronate and tea tree oil, as the weight percentage of salvianolic acid increases, the antibacterial effect of the silicone gel matrix on Staphylococcus aureus and Micrococcus luteus is not significant. However, on the premise of a certain dosage of salvianolic acid and sodium hyaluronate, as the dosage of the compound antibacterial essential oil of tea tree oil increases, the antibacterial effect of the silicone gel matrix on Staphylococcus aureus and Micrococcus luteus is improved to a certain extent.

[0061] For Propionibacterium acnes, on the premise of a certain dosage of sodium hyaluronate and the compound antibacterial essential oil of tea tree oil, as the weight percentage of salvianolic acid increases, the inhibitory effect of the silicone gel matrix on Propionibacterium acnes is enhanced. When the weight percentage of the compound antibacterial essential oil of tea tree oil exceeds 8%, the anti-acne Propionibacterium effect of the silicone gel matrix can be greatly improved, and the antibacterial drug sensitivity level reaches high sensitivity, and the antibacterial effect is better than that against Staphylococcus aureus and Micrococcus luteus.

[0062] (2) Efficacy observation of silicone gel matrix in the treatment of rabbit ear hypertrophic scars

[0063] A. Experimental animals and establishment of rabbit ear scar models

[0064] Forty healthy and clean Japanese white rabbits with intact ears, aged 10 - 12 months and weighing about 2.5 kg were selected. According to the conventional design method for establishing rabbit ear scar models, scar formation could be seen at the 4th week after surgery, and the scar tissue did not exceed the surgical area.

[0065] B. Animal grouping, medication method and specimen processing

[0066] Forty rabbit ear scar models were divided into 8 groups, with 5 in each group, corresponding to A-1 to A-5, control 1-2, and the blank control group respectively.

[0067] After the formation of rabbit ear scars on the 28th day after surgery, the scar wounds of 10 ears of 5 rabbits in group A-1 were externally applied with silicone gel matrix, and applied for 12 hours every day. The same was done for groups A-2 to A-5, and the blank control group was not treated with anything.

[0068] On the 40th day of the experiment, the experimental rabbits were sacrificed by air embolism method. Under sterile conditions, rabbit ear specimens were excised, with some normal skin soft tissue and perichondrium around the scar, and embedded in paraffin for HE staining.

[0069] Scar hyperplasia index HI: It was calculated according to the formula HI = a / b, where a was the vertical distance from the highest point of the scar bulge to the surface of the rabbit ear cartilage, and b was the vertical distance from the edge of the normal skin at the scar periphery to the surface of the rabbit ear cartilage.

[0070] Fibroblast count FBI: First, find the area in the HE-stained specimen that is clearly shown and has the largest number of fibroblasts under a low-power microscope. Then, observe and count 4 different areas under a high-power microscope, and take the average of the results. This number is the number of fibroblasts in the experimental animal.

[0071] The results are shown in Table 3.

[0072] Table 3 Test Results

[0073]

[0074] As can be seen from Table 3, the silicone gel patch matrix has an obvious inhibitory effect on scar hyperplasia in rabbit ears, can significantly reduce the scar area, effectively inhibit the proliferation of fibroblasts in scar tissue, and significantly degrade the collagen fibers in the hypertrophic scar tissue of rabbit ears. Through the comparative experiment, it can be known that the compound antibacterial essential oil of tea tree oil has a greater impact on the anti-scar effect of the silicone gel patch matrix, and is positively correlated with the addition amount. The addition amount of salvianolic acid between 6-10% has no significant impact on the anti-scar effect of the silicone gel patch matrix. However, by comparing Control 1 and Group A-2, it can be seen that salvianolic acid can promote the anti-scar effect of the compound antibacterial essential oil of tea tree oil.

[0075] According to the data comparison in Tables 2-3, it can be seen that the addition of the compound antibacterial essential oil of tea tree oil has a positive effect on the antibacterial performance and anti-scar effect of the silicone gel matrix. On the basis of the components and ratios of the silicone gel matrix defined in Group A-5, the composition and ratio of the compound antibacterial essential oil of tea tree oil were further explored for their influence on the above-mentioned effects of the silicone gel matrix. The composition and ratio of the compound antibacterial essential oil of tea tree oil and the results of the antibacterial effect are shown in Table 4-1, and the results of the anti-scar effect are shown in Table 4-2.

[0076] Table 4-1 Test Results of Antibacterial Effect

[0077]

[0078]

[0079] Table 4-2 Results of Anti-scar Effect

[0080]

[0081] As shown in Table 4-1, different components and ratios of the compound antibacterial essential oil of tea tree oil have no significant impact on the antibacterial property of the silicone gel matrix, and all can play a good antibacterial role.

[0082] As shown in Table 4-2, by comparing groups B-1 to B-3, it was found that as the proportion of citronella essential oil in the tea tree oil compound antibacterial essential oil increased, the anti-scar effect on the silicone gel matrix changed accordingly. An excessive proportion of citronella essential oil would have an adverse effect on the anti-scar effect. Different from group B-2, in groups B-4 and B-5, citronella essential oil and clove essential oil were removed respectively while maintaining their original proportions. It can be seen from this that the synergistic cooperation between citronella essential oil and clove essential oil is the key factor for the tea tree oil compound antibacterial essential oil to exert an excellent anti-scar effect.

[0083] Preparation of the skin care gel patch in Example 2

[0084] The sample A-5 prepared in Example 1 was sent into a plasma device for inflation treatment. After the silicone gel matrix was subjected to a primary curing treatment, it was coated onto a release substrate to obtain a silicone gel layer, and the thickness of the silicone gel layer was controlled to be 2 mm. Among them, the process parameters for inflation treatment in the plasma device were: the set power was 50 W, the pressure was 15 Pa, the oxygen inflation treatment was 120 s, and the oxygen flow rate was 3 m / s. The prepared silicone gel layer was denoted as sample C-1.

[0085] A microneedle substrate was covered on the side of the silicone gel layer (sample C-1) different from the release substrate. After natural standing, the silicone gel matrix was subjected to a secondary curing treatment to obtain the skin care gel patch.

[0086] To explore the influence of the preparation process on the performance of the obtained silicone gel layer, the following further comparisons were made in this example:

[0087] Sample C-2: The difference from sample C-1 was only that it was placed in the plasma device for 120 s but no inflation treatment was carried out.

[0088] Sample C-3: The difference from sample C-1 was only that sample A-5 was not sent into the plasma device for inflation treatment.

[0089] Samples C-1, C-2 and C-3 were tested for air permeability using an air permeability tester. Three parallels were set for each treatment group, and the results were averaged. For the requirements of the air permeability rate of medical dressings, it is stipulated in YY / T 1627-2018 General Requirements for Dressings and Plasters for Acute Wounds that for dressings claiming to be "breathable", the water vapor penetration per 24 h should be not less than 500 g / m 2 . The results are shown in Table 5.

[0090] Table 5 Air permeability test results

[0091]

[0092] As can be seen from Table 5, inflating the silicone gel matrix in a plasma device can significantly improve the air permeability of the finally prepared skin care gel patch before and after the treatment. The improvement of air permeability helps to enhance the comfort of using the gel patch and also contributes to the antibacterial, acne-removing and scar-removing effects.

[0093] Example 3

[0094] As Figure 2 shown, this example provides a device for preparing a skin care gel patch as in Example 2. The structure includes a silicone gel matrix preparation tank 1 and an essential oil preparation tank 2. Tea tree oil, citronella essential oil, clove essential oil and ethanol are put into the essential oil preparation tank 2 to prepare a tea tree oil compound antibacterial essential oil. The tea tree oil compound antibacterial essential oil is sent to the silicone gel matrix preparation tank 1 through a pumping pipeline. Salvianolic acid, sodium hyaluronate and organosilicon polymer are sequentially put into the preparation tank to prepare a silicone gel matrix.

[0095] The device further includes a plasma inflation unit 3 whose feed end is connected to the discharge end of the silicone gel matrix preparation tank 1 through a pumping pipeline. The intake end of the plasma inflation unit 3 is connected to a gas supply unit 9. The gas supply unit 9 supplies oxygen to the plasma inflation unit 3 to perform oxygen inflation treatment on the silicone gel matrix transported to the plasma inflation unit 3. The control of parameters such as the flow rate of oxygen and the treatment time is controlled by the plasma inflation unit 3. The silicone gel matrix is subjected to oxygen inflation treatment in a plasma environment. On the one hand, bubbles are generated in the structure of the silicone gel matrix to optimize the internal structure of the gel matrix and increase its air permeability. On the other hand, after plasma treatment, active functional groups such as hydroxyl groups are generated in the structure of the silicone gel matrix, and the skin-friendly feeling is improved.

[0096] The discharge end of the plasma inflation unit 3 is provided with an injection unit 4 through a pumping pipeline. The injection unit 4 can select common injection nozzles in the cosmetics field and other devices that can inject the inflated silicone gel matrix to the forming roller 5 for forming.

[0097] In the device, the forming roller 5 is used to receive the silicone gel matrix conveyed by the injection unit 4. The heat-conducting circulation unit 8 is connected to the forming roller 5, and the silicone gel matrix is thermally cured for the first time by the heat provided by the heat-conducting circulation unit 8. Driven by an external driving mechanism, such as a motor, the release substrate roller 6 conveys the release substrate. The forming roller 5 conveys the once-cured silicone gel matrix onto the release substrate. After the first thermal curing treatment, the silicone gel matrix is initially formed. As the external driving mechanism drives the forming roller 5 to rotate, the once-thermally cured and formed silicone gel matrix can be covered on the release substrate. Subsequently, the microneedle substrate roller 7 conveys the microneedle substrate and covers it on the side of the silicone gel layer different from the release substrate. The gel patch obtained through the above lamination passes through the drying unit 10, and the silicone gel matrix is secondarily cured to finally obtain the finished skin care gel patch. The forming structure of the forming roller 5 is selected according to the shape of the skin care gel patch to realize the preparation of the coagulation patch with a fixed external structure. Compared with the traditional process of coating and then cutting, the loss rate of the silicone gel matrix can be reduced and the cost can be saved.

[0098] Furthermore, in order to facilitate the once-cured and formed silicone gel matrix to fall onto the release substrate, one end of the drying unit 10 close to the discharge port of the forming roller 5 is connected with a negative pressure air extraction unit 12 through a pipeline. The negative pressure air extraction unit 12 provides suction from one side of the release substrate, so that the once-cured silicone gel matrix quickly detaches from the forming roller 5 and covers the release substrate. In addition, the end far from the discharge port of the forming roller 5 is connected with a heater 11 through a pipeline. The liquid inlet end of the heater 11 is connected with the heat-conducting circulation unit 8 through a pipeline, and the gas inlet end of the heater 11 is connected with the outlet end of the gas supply unit 9 through a pipeline. After being heated by the heat provided by the heat-conducting circulation unit 8 to increase the temperature, the gas provided by the gas supply unit 9 is further heated and then conveyed to the end of the drying unit 10 far from the discharge port of the forming roller 5 to complete the secondary curing of the silicone gel matrix. The optimal curing temperature for the secondary curing is 60 °C.

[0099] Furthermore, as Figures 3 - 4As shown in the figure, the forming roller 5 includes a roller body 51, limiting plates 52 provided at both ends of the roller body 51, and a hollow shaft 53 penetrating through the interior of the roller body 51. Forming molds 54 are oppositely arranged on the outer side of the roller body 51. The shape of the forming molds 54 can be set according to the shape required for the gel patch, such as circular, oval, matrix, etc. Fine pore nets 55 are provided at the positions on the outer side of the roller body 51 corresponding to the forming molds 54. The diameter of the limiting plates 52 near the two forming molds 54 exceeds the diameter of the roller body 51. The limiting plates 52 can contact the release substrate, making the silicone gel matrix close to the negative pressure suction station on the drying unit 10. In addition, vibration components 56 are provided on the limiting plates 52. The vibration components 56 include vibration blocks 561 sleeved on the hollow shaft 53 and elastic members 563 provided on one side of the vibration blocks 561 corresponding to the forming molds 54. One end of the elastic member 563 that is not connected to the vibration block 561 is provided with a fixing block 562 connected to the limiting plate 52. By vibrating the vibration block 561 and transmitting the vibration through the elastic member 563 to the fixing block 562, the fixing block 562 pulls the limiting plate 52 to generate micro-vibrations, achieving the purpose of promoting the feeding of the silicone gel matrix through the structural micro-vibrations when the silicone gel matrix is fed from the forming molds 54.

[0100] In specific applications, the forming roller 5 is driven by a driving mechanism, such as a motor, to rotate slowly. The injection unit 4 injects the silicone gel into the forming molds 54 on the roller body 51. As the forming roller 5 rotates, the silicone gel matrix is evenly coated in the forming molds 54. The heat-conducting medium in the heat-conducting circulation unit 8 is transported through a pipeline into the roller body 51 to heat the roller body 51. After the roller body 51 is heated, a primary curing treatment is performed on the silicone gel matrix in the forming molds 54, enabling the silicone gel matrix to be formed. As the roller body 51 rotates, the forming molds 54 are flipped to be close to the release substrate. At this time, the limiting plates 52 on the roller body 51 abut against the release substrate, making the release substrate closely adhere to the negative pressure pumping station of the drying unit 10. At this time, the negative pressure pumping unit 12 provides suction, and the silicone gel matrix falls onto the release substrate and completely detaches from the forming molds 54 as the release substrate is transported. The silicone gel matrix is transported with the release substrate until it is combined with the microneedle substrate to obtain a gel patch. The gel patch then completes the secondary curing treatment of the silicone gel matrix at the drying station of the drying unit 10, and finally, a skin care gel patch can be obtained through subsequent processing.

[0101] The above embodiments only represent several implementation manners of the present invention. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the patent of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several deformations and improvements can still be made, and these all belong to the protection scope of the present invention.

Claims

1. A skin care product containing a compound antibacterial essential oil of tea tree oil, specifically a skin care gel patch, characterized in that, It includes a silicone gel layer and a microneedle substrate; by weight percentage, the silicone gel layer contains 6-10% salvianolic acid, 6-12% sodium hyaluronate, 8-12% tea tree oil compound antibacterial essential oil, and 70-80% silicone polymer; the components of the tea tree oil compound antibacterial essential oil include tea tree oil, citronella essential oil, and clove essential oil.

2. The skin care product containing the compound bacteriostatic essential oil of tea tree oil according to claim 1, characterized in that, The microneedle substrate includes a polyamide textile layer and a microneedle matrix provided on the polyamide textile layer.

3. The skin care product containing the compound bacteriostatic essential oil with tea tree oil according to claim 1, characterized in that, The silicone polymer is a mixture of polydimethylsiloxane and vinyl polydimethylsiloxane.

4. The skin care product containing the compound bacteriostatic essential oil with tea tree oil according to claim 1, characterized in that The compound volume ratio of the tea tree oil, citronella essential oil, and clove essential oil is 2:0.4-1.2:

1.

5. A preparation method of a skin care product containing a compound antibacterial essential oil with tea tree oil as described in any one of claims 1-4, characterized in that, It includes the following steps: (1) Prepare the tea tree oil compound antibacterial essential oil: Dissolve the tea tree oil, citronella essential oil, and clove essential oil in ethanol, and stir at 45-60 °C for 0.5-1 h to obtain the tea tree oil compound antibacterial essential oil; (2) According to the formula amount, mix the salvianolic acid, sodium hyaluronate, tea tree oil compound antibacterial essential oil, and silicone polymer, and stir evenly under vacuum to obtain a silicone gel matrix; (3) First, send the silicone gel matrix obtained in step (2) into a plasma device for gas filling treatment. After the gas filling treatment is completed, subject the silicone gel matrix to a primary curing treatment and then coat it on a release substrate to obtain a silicone gel layer; (4) Cover the side of the silicone gel layer obtained in step (2) different from the release substrate with the microneedle substrate. After natural standing, subject the silicone gel matrix to a secondary curing treatment to obtain a skin care gel patch.

6. The preparation method of the skin care product containing the compound bacteriostatic essential oil of tea tree oil according to claim 5, characterized in that, In step (3), the process parameters for the gas filling treatment in the plasma device are: set the power to 50-100 W, the pressure to 10-15 Pa, the oxygen gas filling treatment for 60-120 s, and the oxygen flow rate to 2-4 m / s.

7. A preparation device for performing the preparation method according to any one of claims 5-6, comprising a silicone gel matrix preparation tank (1) and an essential oil preparation tank (2), characterized in that, It also includes a plasma gas filling unit (3) whose feed end is connected to the discharge end of a silicone gel matrix preparation tank (1) through a pumping pipeline. The intake end of the plasma gas filling unit (3) is connected to a gas supply unit (9). The gas supply unit (9) supplies oxygen to the plasma gas filling unit (3) to fill the silicone gel matrix with gas. The discharge end of the plasma gas filling unit (3) is connected to an injection unit (4) through a pumping pipeline; A forming roller (5) for receiving the silicone gel matrix transported by the injection unit (4); A heat conduction circulation unit (8) connected to the forming roller (5), which supplies heat through the heat conduction circulation unit (8) to perform a primary curing treatment on the silicone gel matrix; A release substrate roller (6) for transporting the release substrate, and the forming roller (5) transports the primary-cured silicone gel matrix onto the release substrate; A microneedle substrate roller (7) for transporting the microneedle substrate and covering it on the side of the silicone gel layer different from the release substrate; And a drying unit (10) for performing a secondary curing treatment on the silicone gel matrix.

8. The preparation device of a skin care product containing a compound bacteriostatic essential oil with tea tree oil according to claim 7, characterized in that, One end of the drying unit (10) close to the discharge port of the forming roller (5) is connected to a negative pressure air extraction unit (12) through a pipeline, and the other end far from the discharge port of the forming roller (5) is connected to a heater (11) through a pipeline. The liquid inlet end of the heater (11) is connected to the heat conduction circulation unit (8) through a pipeline, and the gas inlet end of the heater (11) is connected to the outlet end of the gas supply unit (9) through a pipeline.

9. The preparation device of a skin care product containing a compound antibacterial essential oil with tea tree oil according to claim 7, characterized in that, The forming roller (5) includes a roller body (51), limit plates (52) provided at both ends of the roller body (51), and a hollow shaft (53) penetrating through the interior of the roller body (51). Forming molds (54) are oppositely arranged on the outer side of the roller body (51), and a fine pore mesh (55) is provided at a position on the outer side of the roller body (51) corresponding to the forming molds (54). The diameter of the limit plates (52) near the two forming molds (54) exceeds the diameter of the roller body (51).

10. The preparation device of a skin care product containing a compound antibacterial essential oil with tea tree oil according to claim 7, characterized in that, A vibration assembly (56) is provided on the limit plates (52). The vibration assembly (56) includes a vibration block (561) sleeved on the hollow shaft (53), and an elastic member (563) provided on one side of the vibration block (561) corresponding to the forming mold (54). A fixing block (562) connected to the limit plate (52) is provided at one end of the elastic member (563) that is not connected to the vibration block (561).

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