Composition containing multiple plant extracts

Abstract

The invention relates to a composition containing various plant extracts, and belongs to the field of cosmetics. According to the composition provided by the invention, various plant extracts are compounded with various components such as other conditioners, humectants and antioxidants, so that the synergistic effect of the various components can be exerted, and the composition is safe, stable and capable of well removing acnes, improving the skin barrier function and repairing damaged skin.

Description

Technical Field

[0001] The present invention relates to a composition containing multiple plant extracts, and particularly to a composition containing multiple plant extracts for treating acne, belonging to the field of cosmetics. Background Art

[0002] Acne, also known as pimples, is a common chronic follicular and sebaceous gland inflammatory skin disease caused by multiple factors, which mostly occurs in areas with strong sebum secretion such as the face. Clinical symptoms include comedones, papules, nodules, cysts and scars. Acne not only causes damage to appearance but also affects mental health.

[0003] The mechanism of acne occurrence mainly involves the following aspects: abnormal androgen regulation and excessive sebum secretion; abnormal keratinization of the sebaceous gland duct, the duct orifice becomes smaller, and the hair follicle orifice is blocked; overgrowth and infection of bacteria such as Propionibacterium acnes; inflammatory immune response, which aggravates the symptoms (externally showing pustules, cysts, etc. visually, and causing pigmentation, scars, etc.). Some studies have shown that the content of squalene in the sebum of acne patients' skin is higher than that of normal healthy people. Squalene is oxidized to peroxides under physiological and external conditions, which promotes the release of more inflammatory factors in keratinocytes, promotes the inflammatory response, and induces the occurrence of acne; Propionibacterium acnes secretes porphyrin during metabolism. Under conditions such as ultraviolet light and visible light, porphyrin can cause blockage of the hair follicle orifice and abnormal keratinization of the sebaceous gland duct through complex reactions, forming comedones, blackheads and acne; moreover, a large number of bacteria such as Propionibacterium acnes multiply, and the lipase produced decomposes sebum to generate free fatty acids, while chemotactic inflammatory cells and mediators, inducing and aggravating the inflammatory response. From the mechanism of acne formation and the resulting consequences, treating and eliminating acne and improving the skin health status can start from aspects such as inhibiting sebum synthesis and secretion, removing keratin, antibacterial, anti-inflammatory and enhancing the barrier function.

[0004] At present, there are already a variety of drugs, cosmetics, etc. for treating acne on the market, but most of them start from a single angle and have deficiencies such as being prone to recurrence after discontinuation, causing skin sensitivity and flushing, and damage to the barrier function. Summary of the Invention

[0005] The present invention aims to provide a composition containing multiple plant extracts. The composition can be used as a dressing, facial mask liquid, etc., and is externally applied to the skin. It can inhibit bacteria, reduce inflammation, repair pigmentation and scars caused by acne, effectively repair and improve the skin barrier function, can efficiently remove acne, improve acne-prone skin and restore it to health, and help the skin maintain a healthy state for a long time.

[0006] In the first aspect, the present invention provides a composition.

[0007] The composition provided by the present invention, or its raw materials for preparation, includes: a conditioner, a humectant, an antioxidant, a surfactant, a thickener, 1,3-butanediol, 1,2-hexanediol, and water.

[0008] In some embodiments, the composition provided by the present invention, or its raw materials for preparation, consists of: a conditioner, a humectant, an antioxidant, a surfactant, a thickener, 1,3-butanediol, 1,2-hexanediol, and water.

[0009] The conditioner includes: Citrus reticulata fruit extract, Panax ginseng root extract, Lonicera confusa extract, Sophora flavescens extract, Centella asiatica extract, and Camellia sinensis leaf extract.

[0010] According to the present invention, the conditioner further includes: dipotassium glycyrrhizinate, hydroxyethyl cellulose, and allantoin.

[0011] The conditioner prepared by compounding the aforementioned plant extracts with dipotassium glycyrrhizinate, hydroxyethyl cellulose, allantoin, etc. can exert the synergistic effects of various components. Compared with a single component, it helps to remove acne, regulate the cell microenvironment, repair damaged skin, enhance the skin barrier function, restore the healthy state of acne-prone skin, and helps the skin maintain a healthy and stable state for a relatively long time.

[0012] In some embodiments, the conditioner may further include one or both of Taraxacum mongolicum extract and Lophatherum gracile extract.

[0013] In some embodiments, the conditioner is preferably: Citrus reticulata fruit extract, Panax ginseng root extract, Lonicera confusa extract, Sophora flavescens extract, Centella asiatica extract, Camellia sinensis leaf extract, dipotassium glycyrrhizinate, hydroxyethyl cellulose, and allantoin.

[0014] According to the present invention, based on the total mass of the composition, the content of the conditioner can be 3.8% - 15%. In some embodiments, based on the total mass of the composition, the content of the conditioner is 4% - 15%. In some embodiments, based on the total mass of the composition, the content of the conditioner is 4% - 12%. In some embodiments, based on the total mass of the composition, the content of the conditioner is 5% - 10%. In some embodiments, based on the total mass of the composition, the content of the conditioner is 6% - 8%.

[0015] The fruit extract of Citrus reticulata has multiple functions such as good anti - inflammation, antibacterial, balancing oil, inhibiting acne, and moisturizing the skin. According to the present invention, based on the total mass of the composition, the content of the fruit extract of Citrus reticulata in the composition can be 1% - 5%. In some embodiments, based on the total mass of the composition, the content of the fruit extract of Citrus reticulata is 1.2% - 5%. In some embodiments, based on the total mass of the composition, the content of the fruit extract of Citrus reticulata is 1.2% - 3%, which is beneficial to obtaining a composition suitable for use and having good efficacy. In some embodiments, based on the total mass of the composition, the content of the fruit extract of Citrus reticulata is 1.2% - 2.5%, which is beneficial to obtaining a composition suitable for use and having good efficacy. In some embodiments, based on the total mass of the composition, the content of the fruit extract of Citrus reticulata is 1.5% - 2%, which is more beneficial to obtaining a composition suitable for use and having good efficacy. In some embodiments, based on the total mass of the composition, the content of the fruit extract of Citrus reticulata is 1.8%.

[0016] The root extract of Panax ginseng can stimulate collagen proliferation and has a good effect on moisturizing the skin and repairing damaged skin. According to the present invention, based on the total mass of the composition, the content of the root extract of Panax ginseng in the composition can be 0.3% - 2.5%. In some embodiments, based on the total mass of the composition, the content of the root extract of Panax ginseng is 0.5% - 1.5%. In some embodiments, based on the total mass of the composition, the content of the root extract of Panax ginseng is 0.5% - 1.2%, which is beneficial to obtaining a composition suitable for use and having good efficacy. In some embodiments, based on the total mass of the composition, the content of the root extract of Panax ginseng is 0.6% - 1%, which is beneficial to obtaining a composition suitable for use and having good efficacy. In some embodiments, based on the total mass of the composition, the content of the root extract of Panax ginseng is 0.8%.

[0017] Extracts of Lonicera confusa, Sophora flavescens, and Camellia sinensis leaves all have certain anti-inflammatory, antibacterial, and oil balance improving effects, which are beneficial for highly efficient acne treatment.

[0018] According to the present invention, based on the total mass of the composition, the content of the extract of Lonicera confusa in the composition can be 0.2% - 2%. In some embodiments, based on the total mass of the composition, the content of the extract of Lonicera confusa is 0.4% - 2%. In some embodiments, based on the total mass of the composition, the content of the extract of Lonicera confusa is 0.5% - 1.5%. In some embodiments, based on the total mass of the composition, the content of the extract of Lonicera confusa is 0.8% - 1.2%. In some embodiments, based on the total mass of the composition, the content of the extract of Lonicera confusa is 1%, which is beneficial to obtaining a composition suitable for use and having good efficacy.

[0019] According to the present invention, based on the total mass of the composition, the content of Sophora flavescens extract in the composition can be 0.3% - 5%. In some embodiments, based on the total mass of the composition, the content of Sophora flavescens extract is 0.5% - 2%. In some embodiments, based on the total mass of the composition, the content of Sophora flavescens extract is 0.5% - 1.8%. In some embodiments, based on the total mass of the composition, the content of Sophora flavescens extract is 1% - 1.4%, which is beneficial to obtaining a composition suitable for use and having good efficacy. In some embodiments, based on the total mass of the composition, the content of Sophora flavescens extract is 1.2%.

[0020] Centella asiatica extract has the effects of anti - inflammation, antioxidant and repairing damaged skin. According to the present invention, based on the total mass of the composition, the content of Centella asiatica extract in the composition can be 0.2% - 3%. In some embodiments, based on the total mass of the composition, the content of Centella asiatica extract is 0.5% - 3%. In some embodiments, based on the total mass of the composition, the content of Centella asiatica extract is 0.5% - 2%. In some embodiments, based on the total mass of the composition, the content of Centella asiatica extract is 0.8% - 1.8%. In some embodiments, based on the total mass of the composition, the content of Centella asiatica extract is 1.2% - 1.8%, which is beneficial to obtaining a composition suitable for use and having good efficacy. In some embodiments, based on the total mass of the composition, the content of Centella asiatica extract is 1.5%.

[0021] According to the present invention, in some embodiments, calculated based on the total mass of the composition, the composition contains cyclodextrin, and the content of cyclodextrin is 0.8% - 18%. According to the present invention, in some embodiments, calculated based on the total mass of the composition, the composition contains cyclodextrin, and the mass ratio of cyclodextrin to the Centella asiatica extract can be 4:1 - 8:1. In some embodiments, calculated based on the total mass of the composition, the content of cyclodextrin in the composition is 2% - 12%. In some embodiments, calculated based on the total mass of the composition, the content of cyclodextrin in the composition is 3.2% - 10.8%. In some embodiments, calculated based on the total mass of the composition, the content of cyclodextrin in the composition is 4% - 10.8%. In some embodiments, calculated based on the total mass of the composition, the content of cyclodextrin in the composition is 6% - 9.6%.

[0022] According to the present invention, the Centella asiatica extract is preferably an inclusion complex formed with cyclodextrin, and the mass ratio of the Centella asiatica extract to cyclodextrin can be 1:4 - 1:6, preferably 1:5 - 1:6.

[0023] The Camellia sinensis leaf extract has certain anti - inflammatory and oil - balance - improving effects, which is beneficial for highly effective acne treatment. According to the present invention, calculated based on the total mass of the composition, the content of the Camellia sinensis leaf extract in the composition can be 0.1% - 2%. In some embodiments, calculated based on the total mass of the composition, the content of the Camellia sinensis leaf extract is 0.4% - 2%. In some embodiments, calculated based on the total mass of the composition, the content of the Camellia sinensis leaf extract is 0.4% - 1.2%. In some embodiments, calculated based on the total mass of the composition, the content of the Camellia sinensis leaf extract is 0.6% - 1%, which is beneficial for obtaining a composition suitable for use and having good efficacy. In some embodiments, calculated based on the total mass of the composition, the content of the Camellia sinensis leaf extract is 0.8%.

[0024] According to the present invention, based on the total mass of the composition, the content of dipotassium glycyrrhizinate in the composition may be 0.05% - 0.5%. In some embodiments, based on the total mass of the composition, the content of dipotassium glycyrrhizinate is 0.1% - 0.3%. In some embodiments, based on the total mass of the composition, the content of dipotassium glycyrrhizinate is 0.12% - 0.3%. In some embodiments, based on the total mass of the composition, the content of dipotassium glycyrrhizinate is 0.12% - 0.2%. In some embodiments, based on the total mass of the composition, the content of dipotassium glycyrrhizinate is 0.15%.

[0025] According to the present invention, based on the total mass of the composition, the content of hydroxyethyl cellulose in the composition may be 0.01% - 0.2%. In some embodiments, based on the total mass of the composition, the content of hydroxyethyl cellulose is 0.03% - 0.15%. In some embodiments, based on the total mass of the composition, the content of hydroxyethyl cellulose is 0.03% - 0.12%. In some embodiments, based on the total mass of the composition, the content of hydroxyethyl cellulose is 0.03% - 0.08%. In some embodiments, based on the total mass of the composition, the content of hydroxyethyl cellulose is 0.05% - 0.1%. In some embodiments, based on the total mass of the composition, the content of hydroxyethyl cellulose is 0.05%.

[0026] According to the present invention, based on the total mass of the composition, the content of allantoin in the composition may be 0.1% - 1%. In some embodiments, based on the total mass of the composition, the content of allantoin is 0.2% - 0.5%. In some embodiments, based on the total mass of the composition, the content of allantoin is 0.2% - 0.4%. In some embodiments, based on the total mass of the composition, the content of allantoin is 0.3%.

[0027] In some embodiments, based on the total mass of the composition, in the composition, the content of dipotassium glycyrrhizinate is 0.1% - 0.3%, the content of hydroxyethyl cellulose is 0.03% - 0.15%, and / or the content of allantoin is 0.2% - 0.5%. In some embodiments, based on the total mass of the composition, in the composition, the content of dipotassium glycyrrhizinate is 0.12% - 0.3%, the content of hydroxyethyl cellulose is 0.03% - 0.12%, and / or the content of allantoin is 0.2% - 0.4%. In some embodiments, based on the total mass of the composition, in the composition, the content of dipotassium glycyrrhizinate is 0.15% - 0.3%, the content of hydroxyethyl cellulose is 0.05% - 0.1%, and / or the content of allantoin is 0.2% - 0.5%.

[0028] In some embodiments, based on the total mass of the composition, the content of dipotassium glycyrrhizinate in the composition is 0.12% - 0.2%, the content of hydroxyethyl cellulose is 0.03% - 0.08%, and / or the content of allantoin is 0.2% - 0.4%. In some embodiments, based on the total mass of the composition, the content of dipotassium glycyrrhizinate in the composition is 0.12% - 0.2%, the content of hydroxyethyl cellulose is 0.05% - 0.08%, and / or the content of allantoin is 0.2% - 0.4%.

[0029] In some embodiments, the composition may contain Taraxacum mongolicum extract; based on the total mass of the composition, the content of Taraxacum mongolicum extract may be 0.1% - 0.5%, or 0.2% - 0.4%.

[0030] In some embodiments, the composition may contain Lophatherum gracile extract; based on the total mass of the composition, the content of Lophatherum gracile extract may be 0.1% - 0.5%, or 0.2% - 0.3%.

[0031] In some embodiments, based on the total mass of the composition, the content of Citrus reticulata fruit extract in the composition is 1.2% - 3%, the content of Panax ginseng root extract is 0.5% - 1.5%, the content of Lonicera confusa extract is 0.4% - 2%, the content of Sophora flavescens extract is 0.5% - 2%, the content of Centella asiatica extract is 0.5% - 2%, the mass ratio of cyclodextrin to Centella asiatica extract is 4:1 - 6:1, and the content of Camellia sinensis leaf extract is 0.4% - 2%.

[0032] In some embodiments, based on the total mass of the composition, the content of Citrus reticulata fruit extract in the composition is 1.2% - 3%, the content of Panax ginseng root extract is 0.5% - 1.5%, the content of Lonicera confusa extract is 0.5% - 2%, the content of Sophora flavescens extract is 0.5% - 2%, the content of Centella asiatica extract is 0.5% - 2%, the mass ratio of cyclodextrin to Centella asiatica extract is 4:1 - 6:1, the content of Camellia sinensis leaf extract is 0.4% - 2%, the content of dipotassium glycyrrhizinate is 0.1% - 0.3%, the content of hydroxyethyl cellulose is 0.03% - 0.12% and the content of allantoin is 0.2% - 0.5%.

[0033] In some embodiments, based on the total mass of the composition, the content of Citrus reticulata fruit extract in the composition is 1.5% - 2%, the content of Panax ginseng root extract is 0.6% - 1%, the content of Lonicera confusa extract is 0.8% - 1.2%, the content of Sophora flavescens extract is 1% - 1.4%, the content of Centella asiatica extract is 1.2% - 1.8%, the mass ratio of cyclodextrin to Centella asiatica extract is 4:1 - 6:1, the content of Camellia sinensis leaf extract is 0.6% - 1%, the content of dipotassium glycyrrhizinate is 0.12% - 0.2%, the content of hydroxyethyl cellulose is 0.03% - 0.08% and the content of allantoin is 0.2% - 0.4%.

[0034] In some embodiments, based on the total mass of the composition, the content of Citrus reticulata fruit extract in the composition is 1.8%, the content of Panax ginseng root extract is 0.8%, the content of Lonicera confusa extract is 1%, the content of Sophora flavescens extract is 1.2%, the content of Centella asiatica extract is 1.5%, the mass ratio of cyclodextrin to Centella asiatica extract is 5:1 - 6:1, the content of Camellia sinensis leaf extract is 0.8%, the content of dipotassium glycyrrhizinate is 0.15%, the content of hydroxyethyl cellulose is 0.05% and the content of allantoin is 0.3%, which is beneficial to obtaining a composition suitable for use and having good efficacy.

[0035] By compounding the above conditioning agents, the composition can have better anti-inflammatory, antibacterial, antioxidant, sebum-balancing and damaged skin-repairing effects, which is beneficial to acne removal and improving the skin barrier function, and making the skin recover and maintain a healthy state.

[0036] The compound conditioning agent provided by the present invention can regulate the water-oil balance of the skin, remove acne, improve the skin's moisturizing ability and barrier function, weaken the inflammatory state of the skin, repair damaged skin, and maintain the stability of the healthy microenvironment of skin cells, which is beneficial to removing acne, eliminating pigmentation and / or scars caused by acne, making the damaged skin recover to health and maintaining the healthy state of the skin for a relatively long time.

[0037] According to the present invention, the moisturizer includes or is one or more of glycerol, trehalose and sodium hyaluronate. In some embodiments, the moisturizer includes or is glycerol, trehalose and sodium hyaluronate.

[0038] According to the present invention, based on the total mass of the composition, the content of the moisturizer in the composition can be 3% - 15%. In some embodiments, based on the total mass of the composition, the content of the moisturizer is 5% - 10%. In some embodiments, based on the total mass of the composition, the content of the moisturizer is 6% - 9%. In some embodiments, based on the total mass of the composition, the content of the moisturizer is 5% - 7%.

[0039] In some embodiments, based on the total mass of the composition, the content of glycerol in the composition can be 2% - 12%. In some embodiments, based on the total mass of the composition, the content of glycerol is 3% - 12%, or 3% - 10%, or 5% - 10%, or 5% - 8%. In some embodiments, based on the total mass of the composition, the content of glycerol is 5% - 6%.

[0040] In some embodiments, based on the total mass of the composition, the content of trehalose in the composition can be 0.1% - 2%. In some embodiments, based on the total mass of the composition, the content of trehalose is 0.2% - 0.8%. In some embodiments, based on the total mass of the composition, the content of trehalose is 0.3% - 0.6%. In some embodiments, based on the total mass of the composition, the content of trehalose is 0.4% - 0.6%. In some embodiments, based on the total mass of the composition, the content of trehalose is 0.5%.

[0041] According to the present invention, the molecular weight of the sodium hyaluronate can be between 10,000 Daltons and 1.3 million Daltons. In some embodiments, the molecular weight of the sodium hyaluronate is between 300,000 Daltons and 1.1 million Daltons. In some embodiments, the molecular weight of the sodium hyaluronate is between 800,000 Daltons and 1 million Daltons.

[0042] In some embodiments, based on the total mass of the composition, the content of sodium hyaluronate in the composition can be 0.05% - 2%. In some embodiments, based on the total mass of the composition, the content of sodium hyaluronate is 0.05% - 1%. In some embodiments, based on the total mass of the composition, the content of sodium hyaluronate is 0.05% - 0.5%. In some embodiments, based on the total mass of the composition, the content of sodium hyaluronate is 0.05% - 0.2%. In some embodiments, based on the total mass of the composition, the content of sodium hyaluronate is 0.05% - 0.15%. In some embodiments, based on the total mass of the composition, the content of sodium hyaluronate is 0.08% - 0.15%. In some embodiments, based on the total mass of the composition, the content of sodium hyaluronate is 0.08%, 0.1%, 0.12%, 0.13% or 0.15%.

[0043] In some embodiments, based on the total mass of the composition, in the composition, preferably, the content of glycerol is 5% - 10%, the content of trehalose is 0.2% - 0.8%, and / or the content of sodium hyaluronate is 0.05% - 1%. In some embodiments, based on the total mass of the composition, in the composition, the content of glycerol is 5% - 8%, the content of trehalose is 0.3% - 0.6%, and / or the content of sodium hyaluronate is 0.05% - 0.5%. In some embodiments, based on the total mass of the composition, in the composition, preferably, the content of glycerol is 5% - 8%, the content of trehalose is 0.3% - 0.6%, and / or the content of sodium hyaluronate is 0.05% - 0.2%. In some embodiments, based on the total mass of the composition, in the composition, preferably, the content of glycerol is 5% - 8%, the content of trehalose is 0.3% - 0.6%, and / or the content of sodium hyaluronate is 0.08% - 0.15%. In some embodiments, based on the total mass of the composition, in the composition, preferably, the content of glycerol is 5% - 6%, the content of trehalose is 0.3% - 0.6%, and / or the content of sodium hyaluronate is 0.08% - 0.15%.

[0044] In some embodiments, based on the total mass of the composition, in the composition, preferably, the content of glycerol is 5.5%, the content of trehalose is 0.5% and the content of sodium hyaluronate is 0.12%.

[0045] The aforementioned humectants help to promote the water - oil balance of the skin, reduce skin moisture loss, maintain an appropriate moist state and promote the absorption and utilization of conditioning agents, etc.

[0046] According to the present invention, the antioxidant may include or be p - hydroxyacetophenone.

[0047] According to the present invention, based on the total mass of the composition, the content of the antioxidant may be 0.1% - 1.5%. In some embodiments, based on the total mass of the composition, the content of the antioxidant is 0.4% - 1%. In some embodiments, based on the total mass of the composition, the content of the antioxidant is 0.5% - 1%. In some embodiments, based on the total mass of the composition, the content of the antioxidant is 0.5% - 0.6%.

[0048] In some embodiments, based on the total mass of the composition, the content of p - hydroxyacetophenone in the composition is 0.1% - 1.5%. In some embodiments, based on the total mass of the composition, the content of p - hydroxyacetophenone in the composition is 0.4% - 1%. In some embodiments, based on the total mass of the composition, the content of p - hydroxyacetophenone in the composition is 0.5% - 1%. In some embodiments, based on the total mass of the composition, the content of p - hydroxyacetophenone in the composition is 0.5% - 0.7%. In some embodiments, based on the total mass of the composition, the content of p - hydroxyacetophenone in the composition is 0.6%.

[0049] According to the present invention, the surfactant may include or be betaine.

[0050] According to the present invention, based on the total mass of the composition, the content of the surfactant may be 0.5% - 5%. In some embodiments, based on the total mass of the composition, the content of the surfactant is 0.5% - 3%. In some embodiments, based on the total mass of the composition, the content of the surfactant is 1% - 3%.

[0051] In some embodiments, based on the total mass of the composition, the content of betaine in the composition is 0.5% - 5%. In some embodiments, based on the total mass of the composition, the content of betaine in the composition is 0.5% - 3%. In some embodiments, based on the total mass of the composition, the content of betaine in the composition is 1% - 3%. In some embodiments, based on the total mass of the composition, the content of betaine in the composition is 1.5% - 2.5%. In some embodiments, based on the total mass of the composition, the content of betaine in the composition is 2%.

[0052] According to the present invention, the thickener may include: xanthan gum, carbomer, or a combination thereof. In some embodiments, the thickener is xanthan gum.

[0053] According to the present invention, based on the total mass of the composition, the content of the thickener can be 0.05% - 1%. In some embodiments, based on the total mass of the composition, the content of the thickener is 0.05% - 0.8%. In some embodiments, based on the total mass of the composition, the content of the thickener is 0.05% - 0.5%. In some embodiments, based on the total mass of the composition, the content of the thickener is 0.1% - 0.5%. In some embodiments, based on the total mass of the composition, the content of the thickener is 0.1% - 0.2%. In some embodiments, based on the total mass of the composition, the content of the thickener is 0.2% - 0.4%. In some embodiments, based on the total mass of the composition, the content of the thickener is 0.1% or 0.2%.

[0054] In some embodiments, based on the total mass of the composition, in the composition, the content of xanthan gum is 0.05% - 1.5%, 0.05% - 1%, 0.05% - 0.5%, or 0.05% - 0.2%, or 0.08% - 0.2%, or 0.1% - 0.2%. In some embodiments, based on the total mass of the composition, in the composition, the content of xanthan gum is 0.1%.

[0055] In some embodiments, based on the total mass of the composition, in the composition, the content of carbomer is 0.05% - 1%, or 0.1% - 0.5%, or 0.1% - 0.2%. In some embodiments, based on the total mass of the composition, in the composition, the content of xanthan gum is 0.05% - 1%, and the content of carbomer is 0.05% - 0.2%. In some embodiments, based on the total mass of the composition, in the composition, the content of xanthan gum is 0.05% - 0.15%, and the content of carbomer is 0.05% - 0.2%.

[0056] In some embodiments, based on the total mass of the composition, in the composition, the content of p-hydroxyacetophenone is 0.1% - 1.5%, the content of betaine is 0.5% - 5%, and / or the content of xanthan gum is 0.05% - 1%. In some embodiments, based on the total mass of the composition, in the composition, the content of p-hydroxyacetophenone is 0.5% - 1%, the content of betaine is 0.5% - 3%, and / or the content of xanthan gum is 0.05% - 0.8%. In some embodiments, based on the total mass of the composition, in the composition, the content of p-hydroxyacetophenone is 0.5% - 0.7%, the content of betaine is 1% - 3%, and / or the content of xanthan gum is 0.05% - 0.2%. In some embodiments, based on the total mass of the composition, in the composition, the content of p-hydroxyacetophenone is 0.5% - 0.7%, the content of betaine is 1% - 3%, and / or the content of xanthan gum is 0.1% - 0.2%.

[0057] In some embodiments, based on the total mass of the composition, in the composition, the content of p-hydroxyacetophenone is 0.6%, the content of betaine is 2%, and / or the content of xanthan gum is 0.1%.

[0058] In some embodiments, based on the total mass of the composition, in the composition, preferably the content of glycerol is 5% - 6%, the content of trehalose is 0.3% - 0.6%, and the content of sodium hyaluronate is 0.08% - 0.15%; the content of p-hydroxyacetophenone is 0.5% - 0.7%, the content of betaine is 1% - 3% and the content of xanthan gum is 0.1% - 0.2%.

[0059] According to the present invention, based on the total mass of the composition, the total content of 1,3-butanediol in the composition can be 2% - 10%. In some embodiments, based on the total mass of the composition, the total content of 1,3-butanediol in the composition is 3% - 10%. In some embodiments, based on the total mass of the composition, the total content of 1,3-butanediol in the composition is 3% - 7%. In some embodiments, based on the total mass of the composition, the total content of 1,3-butanediol in the composition is 3% - 5%, which is beneficial to obtaining a composition suitable for use. In some embodiments, based on the total mass of the composition, the total content of 1,3-butanediol in the composition is 5%.

[0060] According to the present invention, based on the total mass of the composition, the total content of 1,2-hexanediol in the composition may be 0.3%-2%. In some embodiments, based on the total mass of the composition, the total content of 1,2-hexanediol in the composition is 0.3%-1%. In some embodiments, based on the total mass of the composition, the total content of 1,2-hexanediol in the composition is 0.5%-1%. In some embodiments, based on the total mass of the composition, the total content of 1,2-hexanediol in the composition is 0.8%, which is conducive to obtaining a composition suitable for use.

[0061] According to the present invention, the composition may contain 1,3-propylene glycol or may not contain 1,3-propylene glycol. In some embodiments, based on the total mass of the composition, the total content of 1,3-propylene glycol in the composition is 0.1%-5%. In some embodiments, based on the total mass of the composition, the content of 1,3-propylene glycol in the composition is 0.1%-1%. In some embodiments, based on the mass of the composition, the content of 1,3-propylene glycol in the composition is 0.1%-0.5%.

[0062] In some embodiments, based on the total mass of the composition, the total content of 1,3-butanediol in the composition is 2%-10%, and the total content of 1,2-hexanediol is 0.3%-2%. In some embodiments, based on the total mass of the composition, the total content of 1,3-butanediol in the composition is 3%-7%, and the total content of 1,2-hexanediol is 0.5%-1%. In some embodiments, based on the total mass of the composition, the total content of 1,3-butanediol in the composition is 5%, and the total content of 1,2-hexanediol is 0.8%.

[0063] According to the present invention, the composition may not include a fragrance, or may include a fragrance, and the fragrance may be a daily fragrance. According to the present invention, in some embodiments, the content of the fragrance may be 0.01%-0.06% based on the total mass of the composition.

[0064] In some embodiments, based on the total mass of the composition, in the composition, the content of the conditioner is 3.8% - 15%, the content of the humectant is 3% - 15%, the content of the antioxidant is 0.1% - 1.5%, the content of the surfactant is 0.5% - 5%, the content of the thickener is 0.05% - 1%, the total content of 1,3 - butanediol is 2% - 10%, and the total content of 1,2 - hexanediol is 0.3% - 2%; wherein, the mass ratio of Centella asiatica extract to cyclodextrin is 1:4 - 1:6. In some embodiments, based on the total mass of the composition, in the aforementioned composition, the content of the conditioner is 4% - 12%, the content of the humectant is 5% - 10%, the content of the antioxidant is 0.4% - 1%, the content of the surfactant is 0.5% - 3%, and the content of the thickener is 0.05% - 0.8%.

[0065] In some embodiments, based on the total mass of the composition, in the composition, the content of the conditioner is 3.8% - 15%, the content of the humectant is 3% - 15%, the content of the antioxidant is 0.1% - 1.5%, the content of the surfactant is 0.5% - 5%, the content of the thickener is 0.05% - 1%, the total content of 1,3 - butanediol is 2% - 10%, and the total content of 1,2 - hexanediol is 0.3% - 2%; wherein, the mass ratio of Centella asiatica extract to cyclodextrin is 1:4 - 1:6; the balance is water.

[0066] In some embodiments, based on the total mass of the composition, in the composition, the content of the conditioner is 5% - 10%, the content of the humectant is 5% - 10%, the content of the antioxidant is 0.4% - 1%, the content of the surfactant is 0.5% - 3%, and the content of the thickener is 0.05% - 0.8%; the total content of 1,3 - butanediol is 2% - 10%, and the total content of 1,2 - hexanediol is 0.3% - 2%; wherein, the mass ratio of Centella asiatica extract to cyclodextrin is 1:4 - 1:6; the balance is water.

[0067] In some embodiments, based on the total mass of the composition, in the composition, the content of the conditioner is 5% - 10%, the content of the humectant is 5% - 10%, the content of the antioxidant is 0.4% - 1%, the content of the surfactant is 0.5% - 3%, and the content of the thickener is 0.1% - 0.5%; the total content of 1,3 - butanediol is 3% - 7%, the total content of 1,2 - hexanediol is 0.5% - 1%; wherein, the mass ratio of Centella asiatica extract to cyclodextrin is 1:4 - 1:6; the balance is water.

[0068] In some embodiments, based on the total mass of the composition, in the composition, the content of the conditioner is 4% - 11%, the content of the humectant is 5% - 10%, the content of the antioxidant is 0.4% - 1%, the content of the surfactant is 0.5% - 3%, and the content of the thickener is 0.1% - 0.5%; the total content of 1,3 - butanediol is 3% - 7%, and the total content of 1,2 - hexanediol is 0.5% - 1%; the content of cyclodextrin is 2% - 12%; the balance is water.

[0069] In some embodiments, based on the total mass of the composition, in the composition, the content of Citrus reticulata fruit extract is 1.2% - 5%, the content of Panax ginseng root extract is 0.3% - 2.5%, the content of Lonicera confusa extract is 0.2% - 2%, the content of Sophora flavescens extract is 0.3% - 5%, the content of Centella asiatica extract is 0.5% - 3%, the content of Camellia sinensis leaf extract is 0.1% - 2%, the content of dipotassium glycyrrhizinate is 0.05% - 0.5%, the content of hydroxyethyl cellulose is 0.01% - 0.2%, and the content of allantoin is 0.1% - 1%; the content of glycerol is 2% - 12%, the content of trehalose is 0.1% - 2%, and the content of sodium hyaluronate is 0.05% - 2%; the content of p - hydroxyacetophenone is 0.1% - 1.5%; the content of betaine is 0.5% - 5%; and the content of xanthan gum is 0.05% - 1%; the total content of 1,3 - butanediol is 2% - 10%, and the total content of 1,2 - hexanediol is 0.3% - 2%; wherein, the mass ratio of Centella asiatica extract to cyclodextrin is 1:4 - 1:6; the balance is water.

[0070] In some embodiments, based on the total mass of the composition, in the composition, the content of Citrus reticulata fruit extract is 1.2% - 5%, the content of Panax ginseng root extract is 0.5% - 2.5%, the content of Lonicera confusa extract is 0.2% - 2%, the content of Sophora flavescens extract is 0.3% - 5%, the content of Centella asiatica extract is 0.5% - 3%, the content of Camellia sinensis leaf extract is 0.1% - 2%, the content of dipotassium glycyrrhizinate is 0.05% - 0.5%, the content of hydroxyethyl cellulose is 0.01% - 0.2%, and the content of allantoin is 0.1% - 1%; the content of glycerol is 2% - 10%, the content of trehalose is 0.1% - 2%, and the content of sodium hyaluronate is 0.05% - 2%; the content of p - hydroxyacetophenone is 0.1% - 1.5%; the content of betaine is 0.5% - 5%; and the content of xanthan gum is 0.05% - 1%; the total content of 1,3 - butanediol is 2% - 10%, and the total content of 1,2 - hexanediol is 0.3% - 2%; the mass ratio of the Centella asiatica extract to cyclodextrin is 1:4 - 1:6; the balance is water.

[0071] In some embodiments, based on the total mass of the composition, in the composition, the content of Citrus reticulata fruit extract is 1.2% - 3%, the content of Panax ginseng root extract is 0.5% - 1.5%, the content of Lonicera confusa extract is 0.4% - 2%, the content of Sophora flavescens extract is 0.5% - 2%, the content of Camellia sinensis leaf extract is 0.4% - 2%, the content of Centella asiatica extract is 0.5% - 2%, the content of cyclodextrin is 2% - 12%, the content of dipotassium glycyrrhizinate is 0.1% - 0.3%, the content of hydroxyethyl cellulose is 0.03% - 0.15%, and the content of allantoin is 0.2% - 0.5%; the content of glycerol is 5% - 10%, the content of trehalose is 0.2% - 0.8%, and the content of sodium hyaluronate is 0.05% - 0.5%; the content of p - hydroxyacetophenone is 0.4% - 1%; the content of betaine is 0.5% - 3%; the content of xanthan gum is 0.05% - 0.5%; the total content of 1,3 - butanediol is 3% - 10%, and the total content of 1,2 - hexanediol is 0.3% - 1%; the balance is water.

[0072] In some embodiments, based on the total mass of the composition, in the composition, the content of Citrus reticulata fruit extract is 1.2% - 3%, the content of Panax ginseng root extract is 0.5% - 1.5%, the content of Lonicera confusa extract is 0.4% - 2%, the content of Sophora flavescens extract is 0.5% - 2%, the content of Camellia sinensis leaf extract is 0.4% - 2%, the content of Centella asiatica extract is 0.5% - 2%, the content of cyclodextrin is 2% - 12%, the content of dipotassium glycyrrhizinate is 0.1% - 0.3%, the content of hydroxyethyl cellulose is 0.03% - 0.12%, and the content of allantoin is 0.2% - 0.4%; the content of glycerol is 5% - 8%, the content of trehalose is 0.2% - 0.8%, and the content of sodium hyaluronate is 0.05% - 0.2%; the content of p - hydroxyacetophenone is 0.5% - 1%; the content of betaine is 1% - 3%; the content of xanthan gum is 0.1% - 0.2%; the total content of 1,3 - butanediol is 3% - 7%, and the total content of 1,2 - hexanediol is 0.5% - 1%; the balance is water.

[0073] In some embodiments, based on the total mass of the composition, in the composition, the content of Citrus reticulata fruit extract is 1.5% - 2%, the content of Panax ginseng root extract is 0.6% - 1%, the content of Lonicera confusa extract is 0.8% - 1.2%, the content of Sophora flavescens extract is 1% - 1.4%, the content of Centella asiatica extract is 1.2% - 1.6%, the mass ratio of the Centella asiatica extract to cyclodextrin is 1:5 - 1:6, the content of Camellia sinensis leaf extract is 0.6% - 1%, the content of dipotassium glycyrrhizinate is 0.12% - 0.2%, the content of hydroxyethyl cellulose is 0.03% - 0.08%, the content of allantoin is 0.2% - 0.4%; the content of glycerol is 5% - 6%, the content of trehalose is 0.4% - 0.6%, and the content of sodium hyaluronate is 0.08% - 0.15%; the content of p - hydroxyacetophenone is 0.5% - 0.7%, the content of betaine is 1% - 3%, the content of xanthan gum is 0.1% - 0.2%; the total content of 1,3 - butanediol is 3% - 7%, the total content of 1,2 - hexanediol is 0.5% - 1%; the balance is water.

[0074] According to the research of the present invention, the foregoing various components and the combination of the various components in the said content have excellent safety and stability, can exert the combined effects of each component, efficiently remove acne, repair the water-oil balance and barrier function of the skin, and improve skin health. The foregoing composition, by compounding a variety of plant ingredients, can not only exert the effects of a variety of plant ingredients in removing acne, improving the water-oil balance and microenvironment, repairing and enhancing the skin barrier function, reducing / eliminating the skin inflammatory state, etc., but also has low irritation, has a good skin feel during use, and can maintain the stable state after the repair of acne skin for a long time; and through the compounding of a variety of ingredients and the control of the content of various ingredients, the efficacy of the combined ingredients can be better exerted, it is easily absorbed by the skin, helps to remove acne without adverse sensations such as irritation and stinging, soothes the skin, can make the skin enhance the hydration effect, is beneficial to skin moisturization, has extremely strong antioxidant and cell proliferation promoting effects, can scavenge free radicals, relieve and reduce inflammation, repair damaged skin, enhance the skin barrier function, repair skin health, improve the health condition of damaged skin and enable it to maintain a healthy state for a relatively long time.

[0075] On the other hand, the present invention provides a method for preparing the foregoing composition.

[0076] A method for preparing the foregoing composition, comprising: Mix a part of 1,3-butanediol, a part of 1,2-hexanediol and part or all of the antioxidant, heat and stir to dissolve to obtain Liquid A; Add a part of 1,3-butanediol, a part of water, a thickening agent, a part of a humectant and a part of a conditioner into a container, heat and stir to mix evenly to obtain Liquid B; Mix the Centella asiatica extract, cyclodextrin and a part of water, stir to mix evenly to form Liquid C; or mix the inclusion complex of Centella asiatica extract and cyclodextrin with a part of water, stir to mix evenly to obtain Liquid C; Under the condition of heating and stirring, add the foregoing Liquid A to Liquid B and mix evenly; control the temperature below 45°C, add the foregoing Liquid C, a surfactant, the remaining humectant, and a part of the conditioner, and stir to mix evenly; control the temperature below 35°C, add all the remaining materials, stir evenly; filter and discharge to obtain the composition.

[0077] In some embodiments, heat to 50°C - 85°C or 60°C - 70°C, stir until completely dissolved to obtain Liquid A.

[0078] In some embodiments, heat to 70°C - 85°C, stir and mix evenly to obtain Liquid B.

[0079] According to the present invention, stirring can be carried out under the condition of 200 rpm - 2000 rpm (revolutions per minute). In some embodiments, stirring is carried out under the condition of 200 rpm - 1500 rpm. In some embodiments, stirring is carried out under the condition of 500 rpm - 1500 rpm.

[0080] According to the present invention, filtering can be carried out using a sieve mesh of 150 mesh - 300 mesh. In some embodiments of the method, filtering is carried out using a 200 - mesh sieve mesh.

[0081] In some embodiments, a method for preparing the aforementioned composition comprises: Mix a portion of 1,3 - butanediol, a portion of 1,2 - hexanediol and an antioxidant, heat at 60°C - 70°C and stir under the condition of 500 rpm - 1500 rpm until dissolved to obtain Liquid A; Add a portion of 1,3 - butanediol, a portion of water, glycerol, sodium hyaluronate, hydroxyethyl cellulose and a thickening agent into a container, heat at 50°C - 60°C and stir under the condition of 500 rpm - 1500 rpm until evenly mixed to obtain Liquid B; Mix the Centella asiatica extract, cyclodextrin and a portion of water, stir and mix evenly under the condition of 500 rpm - 1500 rpm to form Liquid C; or mix the inclusion complex of Centella asiatica extract and cyclodextrin with a portion of water, stir under the condition of 500 rpm - 1500 rpm and mix evenly to obtain Liquid C; Heat at 70°C - 85°C and under the condition of 500 rpm - 1500 rpm, add the aforementioned Liquid A into Liquid B and mix evenly; control the temperature below 45°C, add the aforementioned Liquid C, allantoin, dipotassium glycyrrhizinate, a surfactant and the remaining humectant (trehalose), stir and mix evenly at 500 rpm - 1500 rpm; control the temperature below 35°C, add all the remaining materials, stir and mix evenly at 500 rpm - 1500 rpm; filter through a 150 - mesh - 300 - mesh sieve mesh, discharge to obtain the composition.

[0082] In some embodiments, the remaining materials include a conditioning agent, an antioxidant and a solvent; the solvent includes water, 1,3 - butanediol, and / or 1,2 - hexanediol. In some embodiments, the remaining materials include a conditioning agent, an antioxidant and a solvent; the solvent includes water, 1,3 - butanediol and 1,2 - hexanediol. In some embodiments, the remaining materials include the remaining extract conditioning agent, an antioxidant, water, 1,3 - butanediol and 1,2 - hexanediol.

[0083] In the method, when preparing Liquid A, Liquid B or Liquid C, the amount of water used can be selected according to the amount of raw materials fed, so as to obtain a homogeneous mixture, such as one-fifth, one-fourth, one-third, or one-half of the total amount of water, etc.

[0084] The composition can be directly applied to the skin surface for use, or it can be used together with a mask cloth after soaking the mask cloth.

[0085] According to the formula and method provided by the present invention, a stable and safe composition for acne-prone skin / acne skin that can effectively remove acne and moisturize can be simply, controllably and feasibly prepared. Description of the Drawings

[0086] Figure 1 Show the lipid droplet staining results of each test group in Example 5. Detailed Embodiments

[0087] The term "comprising" or "including" is an open expression, that is, it includes the content specified by the present invention, but does not exclude other aspects.

[0088] In the present invention, "optionally" means that it may or may not be present. For example, "optionally containing" means that it may or may not contain.

[0089] The term "a variety of" means two or more than two, such as two, three, four or five, etc.

[0090] In the description of this specification, the description with reference to terms such as "one embodiment", "some embodiments", "some embodiments", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0091] In the present invention, room temperature is the ambient temperature, at 20°C - 30°C, or 22°C - 28°C, or 25°C.

[0092] In the present invention, the content or concentration is in terms of mass fraction.

[0093] In order to enable those skilled in the art to better understand the technical solutions of the present invention, some non-limiting embodiments are further disclosed below to further elaborate on the present invention.

[0094] Example 1 Formulation table: Preparation method: According to the formulation, obtain each material (which can be directly purchased from the market or prepared from individual materials according to the ratio of the formulation), and then: According to the formulation table, mix 1,3 - butanediol, 1,2 - hexanediol and p - hydroxyacetophenone, stir at 1000 rpm, heat to 60°C - 70°C, and stir until completely dissolved to obtain Liquid A; According to the formulation table, mix 1,3 - butanediol, glycerol, sodium hyaluronate, xanthan gum, hydroxyethyl cellulose and part of water (about one - quarter of the amount used in No. 1, which can be appropriately increased or decreased according to the dissolution situation), stir at 1200 rpm, heat to 75°C - 85°C, and stir and mix evenly to obtain Liquid B; Mix the extract of Centella asiatica, cyclodextrin and part of water (about one - third of the amount used in No. 1, which can be appropriately increased or decreased according to the dissolution situation), stir at 1000 rpm, and mix evenly to obtain Liquid C; Add the aforementioned Liquid A to Liquid B, stir at 75°C - 85°C and 1000 rpm for 30 minutes - 40 minutes; then cool down to 35°C - 45°C, add the aforementioned Liquid C and the materials numbered 2 - 5, and stir evenly at 1000 rpm; then control the temperature at 35°C - 20°C, add the material numbered 6 and the remaining water, and stir evenly at 800 rpm; filter through a 200 - mesh sieve, discharge, fill, and obtain a light - yellow liquid composition.

[0095] Use experience test and results: Apply the compositions obtained from each formulation to the back of the palm, and record the usage feelings; it is found that: Formulation 1 and Formulation 2: smooth to apply, fast absorption, high fluidity (the liquid drops fall quickly); Formulation 3: smooth to apply, fast absorption, slightly lower fluidity (the liquid drops fall slower than Formulation 1); Formulation 4: relatively sticky, lower fluidity (the liquid drops are not easy to drop), slightly slower absorption after application, and relatively slightly worse comfort, but still acceptable; 1 hour after application, no discomfort such as stinging or itching is observed.

[0096] Example 2: Chicken embryo chorioallantoic membrane (CAM membrane) test Positive control: 0.1 mol / L NaOH solution; Blank control: 0.9% NaCl aqueous solution; Sample: The composition obtained from Formulation 4 in Example 1, prepared with water to 100 mg / mL; Method: Under the conditions of an incubator temperature of 37°C - 38°C and a relative humidity of 55% - 70%, when the chicken embryos are hatched to 9 days old, check and discard the defective chicken embryos; mark the position of the air chamber on the surface of the normal chicken embryo eggshell, remove part of the eggshell to expose the white egg membrane; carefully remove the inner membrane with forceps to ensure that the vascular membrane is not damaged; drip a small amount of physiological saline on the surface of the eggshell membrane to fully moisten it, pour it out, and carefully remove the eggshell membrane with forceps to ensure that the exposed chorioallantoic membrane is intact without any damage; directly drop 0.3 mL of the test substance onto the surface of the chorioallantoic membrane, observe the reaction, and record the time (s, seconds) when each toxic effect appears within 5 minutes, and calculate the irritation score (obtain the score according to the observed chorioallantoic membrane toxic effect indicators such as bleeding, coagulation, and vascular lysis). Irritation scoring criteria: The results are shown in the following table.

[0097] According to the results, it can be seen that the test sample has no irritation.

[0098] Example 3: Safety and stability test Referring to the methods disclosed in GB / T 29665 - 2013 and "Technical Specifications for Cosmetics Safety" (2015 edition, Chapters 4 and 5), test the heat resistance, cold resistance, and centrifugal stability of the composition obtained from Formulation 3 in Example 1. The specific conditions and results are shown in the following table.

[0099] According to the test results, it can be seen that the composition provided by the present invention has good safety and stability and is suitable for daily use.

[0100] Example 4: Hyaluronidase inhibition test Principle: Hyaluronidase is strongly correlated with inflammation and allergy, and hyaluronic acid can inhibit the inflammatory response; hyaluronidase is a specific lyase of hyaluronic acid, and inhibiting the activity of hyaluronidase can ensure the normal content and function of hyaluronic acid. Therefore, the anti-inflammatory activity of a substance can be evaluated by the hyaluronidase inhibition rate. The greater the hyaluronic acid inhibition rate, the stronger the anti-inflammatory activity; inhibiting hyaluronidase can reduce the damage of skin inflammatory reactions to the skin barrier structure and nerve endings.

[0101] Positive control group: Sodium cromoglycate aqueous solution, the test concentration is 20 mg / mL; blank control group: PBS buffer solution; Sample group: The compositions obtained from each formulation in Example 1 are respectively prepared into 100 mg / mL with water; Method: Take 200 μL each of the test solution, hyaluronidase solution (500 U / mL), and sodium hyaluronate (0.5 mg / mL), mix them, incubate at 37 °C for 20 min, and then add 200 μL of CTAB solution (cetyltrimethylammonium bromide, 5 mg / mL); Pipette 200 μL of each reaction solution into a 96-well microplate, and measure the absorbance at 600 nm; Calculate the effect of each test product on the activity of hyaluronidase and calculate the statistical difference P value; The results are shown in the following table.

[0102] Note: p < 0.05 indicates a significant difference; According to the results, the composition provided by the present invention has an inhibitory effect on hyaluronidase (and within a certain content range, the inhibitory effect is higher), and has an anti-inflammatory and soothing effect on the skin. Among them, the content of the conditioner in Formula 4 is higher than that in Formulas 1 - 3, and the inhibition rate is relatively higher. The content of the plant extract conditioner in Formula 1 is relatively the lowest, and the inhibitory effect is relatively the weakest, but still has an inhibitory effect.

[0103] Example 5: Oil Control Test Reagents: MEM medium, phosphate buffer solution, Oil Red O solution; Inducers: 5α-DHT (5α-dihydrotestosterone), linoleic acid; Grouping: Blank control group; Negative control group; Sample group: obtained from Formula 3 in Example 1, made into 0.25 mg / mL with phosphate buffer solution; Based on human immortalized sebaceous gland cells SZ95 for evaluation, stimulated with 5α-DHT and linoleic acid to establish an in vitro oil secretion model. After applying the sample for treatment, evaluate the oil control efficacy of the test sample by evaluating the trend of lipid droplet synthesis.

[0104] Cell seeding: Dilute the cells with MEM medium to the seeding density, and then seed them into a 96-well microplate, 2*10 5 cells / well, and the liquid addition volume per well is 200 μL; After the seeding is completed, place it in a CO2 incubator and culture for 24 h ± 2 h; Application of sample treatment: After the cells in the 96-well microplate reach the appropriate confluence, perform the operation of applying the sample according to the grouping; Discard the medium in the 96-well microplate, add MEM medium containing the sample, 5α-DHT, and linoleic acid to the sample wells; Add MEM medium to the blank control wells, and add MEM medium containing 5α-DHT and linoleic acid to the negative control wells. The liquid addition volume per well is 200 μL, and each group has 3 replicate wells; After the drug administration is completed, place the 96-well microplate in a CO2 incubator and culture for 24 h ± 2 h; Staining: Discard the old liquid in the 96-well plate, wash the plate twice with phosphate buffer solution, add 100 μL of paraformaldehyde to each well to fix the cells; discard the fixing solution, add Oil Red O solution and stain at 37 °C for 30 min; then discard the Oil Red O solution, add an appropriate amount of ultrapure water and wash for 5 min; repeat 2 - 3 times; Result processing: Take pictures under the microscope and record the staining results, use image analysis software to calculate the percentage of stained area "%Area"; use SPSS analysis software, and perform independent sample t-test for data statistical analysis between groups. p < 0.05 indicates statistical difference; p > 0.05 indicates no statistical difference.

[0105] Result: See the appendix for the staining results Figure 1 ; The %Area of the blank control group was 6.9, that of the negative control group was 17.7, and that of the sample group was 8.9; compared with the blank group, the amount of lipid droplet synthesis in the negative control group increased extremely significantly, indicating that the inducer stimulation in this experiment was effective; when the dosing concentration of the sample group was 0.25 mg / mL, compared with the negative control group, the amount of lipid droplet synthesis in the sample group decreased, with statistical difference (p < 0.05), indicating that the sample had the ability to inhibit lipid droplet synthesis at this tested concentration, and had the effect of regulating oil secretion and adjusting the water-oil balance; see the appendix for the results Figure 1 .

[0106] Example 6: Human test Subject information: Select 30 Chinese healthy male / female subjects (8 males and 22 females) with a certain number of acne and acne on the facial skin (no birthmarks, scratches, white spots, pigmented moles, etc. on the face), no allergic diseases, no history of allergy to cosmetics or other topical preparations, and an age range of 18 - 40 years old, with an average age of 30 years old.

[0107] During the test, temperature: 20 °C - 22 °C; relative humidity: 50% ± 10%.

[0108] Instruments: Skin moisture tester Corneometer CM825, facial image analyzer VISIA (Canfield, USA).

[0109] Product and usage method: The product obtained from Formula 3 in Example 1; after cleansing the face every evening, take an appropriate amount of the product obtained from Formula 3 and apply it on the face, gently massage and absorb, and wipe off the residue after 15 minutes.

[0110] Test method: Adopt the method of self-control before and after: Count the acne / acne on the subjects' faces. The smaller the value, the fewer the acne / acne, and vice versa; measure the skin stratum corneum moisture content (cheek) and skin a* value of the subjects; The subjects cleaned their faces and dried their skin with a dry facial tissue. They sat quietly in a laboratory at a temperature of 21°C ± 1°C and a humidity of 50%RH ± 10%RH for 30 minutes; the instrument was operated to statistically analyze and measure the baseline values of relevant indicators of the test sites of the subjects; the subjects used the product according to the product usage requirements and provided a product usage diary; after continuous use for the specified time, the subjects were visited. The subjects cleaned their faces and dried their skin with a dry facial tissue. They sat quietly in a laboratory at a temperature of 21°C ± 1°C and a humidity of 50%RH ± 10%RH for 30 minutes; the instrument was used to statistically analyze and measure the relevant indicators of the test sites of the subjects; the staff checked and retrieved the product usage diaries of the subjects and statistically retrieved the products. The experimental results were compared by statistical test methods to determine whether there were statistical differences; the data were statistically analyzed using SPSS 26.0. If the data were normally distributed, the T-test method was used for statistical analysis; if the data were non-normally distributed, the rank sum test method was used for statistical analysis; the statistical methods all used two-tailed tests, and the significance level α = 0.05.

[0111] The calculation formula for the change rate is as follows: The change rate after using the product for X days = (the average value after X days - the average value before use) / the average value before use * 100%, and the positive value is taken to obtain the improvement rate; among them, the average value before use is the baseline value of the parameter measured before using the product, and the average value is taken; the average value after X days is the numerical value of the parameter measured after using the product for X days, and the average value is taken.

[0112] Results: No adverse reactions occurred in all subjects; some test results are shown in the following table; Note: p < 0.05 indicates a significant difference.

[0113] After 14 days of use, the subjects filled out a questionnaire, and the results were summarized. The percentage of those who indicated agreement with a certain answer was marked. For details, see the following table.

[0114] According to the above results, it can be seen that the composition provided by the present invention has a good effect of improving skin water content, controlling oil, reducing inflammation and enhancing skin barrier function. It can increase skin water content, inhibit skin oil secretion, regulate the water-oil balance, reduce inflammatory symptoms, reduce the number of acne, reduce the scars caused by acne, can effectively remove acne, improve skin health conditions, and has no adverse stimulation effects, and is safe and stable.

[0115] The solution of the present invention has been described through preferred embodiments. It is obvious that relevant personnel can make changes or appropriate modifications and combinations to the solution or application described herein within the content and scope of the present invention to implement and apply the technology of the present invention. Those skilled in the art can draw on the content of this article and appropriately improve the conditions / parameters to implement and / or apply the technology of the present invention. It should be particularly noted that all such similar substitutions and modifications are obvious to those skilled in the art, and they are all regarded as being included in the present invention.

Claims

1. A composition, the composition or the raw materials for its preparation comprising: a conditioner, a humectant, an antioxidant, a surfactant, a thickener, 1,3 - butanediol, 1,2 - hexanediol and water; wherein, The conditioner comprises: Citrus reticulata fruit extract, Panax ginseng root extract, Lonicera confusa extract, Sophora flavescens extract, Centella asiatica extract, Camellia sinensis leaf extract, dipotassium glycyrrhizinate, hydroxyethyl cellulose and allantoin; calculated based on the total mass of the composition, the content of Citrus reticulata fruit extract is 1% - 5%; The humectant comprises: glycerin, trehalose and sodium hyaluronate; The antioxidant comprises: p - hydroxyacetophenone; The surfactant comprises: betaine; The thickener comprises: xanthan gum, carbomer, or a combination thereof.

2. The composition according to claim 1, calculated based on the total mass of the composition, the content of the conditioner is 3.8% - 15%, the content of the humectant is 3% - 15%, the content of the antioxidant is 0.1% - 1.5%, the content of the surfactant is 0.5% - 5%, and the content of the thickener is 0.05% - 1%.

3. The composition according to claim 1, calculated based on the total mass of the composition, wherein, The total content of 1,3 - butanediol is 2% - 10%, and the total content of 1,2 - hexanediol is 0.3% - 2%; the composition optionally comprises 1,3 - butanediol.

4. The composition according to claim 1, the Centella asiatica extract forms an inclusion complex with cyclodextrin, and the mass ratio of Centella asiatica extract to cyclodextrin is 1:4 - 1:

6.

5. The composition according to claim 1, calculated based on the total mass of the composition, the content of the conditioner is 4% - 12%, the content of the humectant is 5% - 10%, the content of the antioxidant is 0.4% - 1%, the content of the surfactant is 0.5% - 3%, and the content of the thickener is 0.05% - 0.8%.

6. The composition according to any one of claims 4-5, calculated based on the total mass of the composition, wherein, The total content of 1,3 - butanediol is 3% - 7%, the total content of 1,2 - hexanediol is 0.5% - 1%; the mass ratio of Centella asiatica extract to cyclodextrin is 1:5 - 1:6; the balance is water.

7. The composition according to any one of claims 1-5, based on the total mass of the composition, in the composition, the content of Citrus reticulata fruit extract is 1.2%-5%, the content of Panax ginseng root extract is 0.5%-2.5%, the content of Lonicera confusa extract is 0.2%-2%, the content of Sophora flavescens extract is 0.3%-5%, the content of Centella asiatica extract is 0.5%-3%, the content of Camellia sinensis leaf extract is 0.1%-2%, the content of dipotassium glycyrrhizinate is 0.05%-0.5%, the content of hydroxyethyl cellulose is 0.01%-0.2%, and the content of allantoin is 0.1%-1%; the content of glycerol is 2%-12%, the content of trehalose is 0.1%-2%, and the content of sodium hyaluronate is 0.05%-2%; the content of p-hydroxyacetophenone is 0.1%-1.5%; the content of betaine is 0.5%-5%; and the content of xanthan gum is 0.05%-1%.

8. The composition according to any one of claims 1-5, based on the total mass of the composition, in the composition, the content of Citrus reticulata fruit extract is 1.2%-3%, the content of Panax ginseng root extract is 0.5%-1.5%, the content of Lonicera confusa extract is 0.4%-2%, the content of Sophora flavescens extract is 0.5%-2%, the content of Camellia sinensis leaf extract is 0.4%-2%, the content of Centella asiatica extract is 0.5%-2%, the content of cyclodextrin is 2%-12%, the content of dipotassium glycyrrhizinate is 0.1%-0.3%, the content of hydroxyethyl cellulose is 0.03%-0.12%, and the content of allantoin is 0.2%-0.5%; the content of glycerol is 5%-8%, the content of trehalose is 0.2%-0.8%, and the content of sodium hyaluronate is 0.05%-0.2%; the content of p-hydroxyacetophenone is 0.5%-1%; the content of betaine is 1%-3%; the content of xanthan gum is 0.1%-0.2%; the total content of 1,3-butanediol is 3%-7%, and the total content of 1,2-hexanediol is 0.5%-1%; the balance is water.

9. The composition according to claim 4, based on the total mass of the composition, in the composition, the content of Citrus reticulata fruit extract is 1.5% - 2%, the content of Panax ginseng root extract is 0.6% - 1%, the content of Lonicera confusa extract is 0.8% - 1.2%, the content of Sophora flavescens extract is 1% - 1.4%, the content of Centella asiatica extract is 1.2% - 1.6%, the content of cyclodextrin is 6% - 9.6%, the content of Camellia sinensis leaf extract is 0.6% - 1%, the content of dipotassium glycyrrhizinate is 0.12% - 0.2%, the content of hydroxyethyl cellulose is 0.03% - 0.08%, and the content of allantoin is 0.2% - 0.4%; the content of glycerol is 5% - 6%, the content of trehalose is 0.4% - 0.6%, and the content of sodium hyaluronate is 0.08% - 0.15%; the content of p-hydroxyacetophenone is 0.5% - 0.7%, the content of betaine is 1% - 3%, and the content of xanthan gum is 0.1% - 0.2%; the total content of 1,3-butanediol is 3% - 7%, and the total content of 1,2-hexanediol is 0.5% - 1%; the balance is water.

10. A method for preparing the composition according to any one of claims 1 - 9, comprising: Mixing part of 1,3-butanediol, part of 1,2-hexanediol and part or all of the antioxidant, heating at 60°C - 70°C and stirring at 500 rpm - 1500 rpm to dissolve, obtaining liquid A; Adding part of 1,3-butanediol, part of water, glycerol, sodium hyaluronate, hydroxyethyl cellulose and the thickening agent into a container, heating at 70°C - 85°C and stirring at 500 rpm - 1500 rpm to mix evenly, obtaining liquid B; Mixing the Centella asiatica extract, cyclodextrin and part of water, stirring at 500 rpm - 1500 rpm to mix evenly to form liquid C; or mixing the inclusion complex of Centella asiatica extract and cyclodextrin with part of water, stirring at 500 rpm - 1500 rpm to mix evenly, obtaining liquid C; Heating at 70°C - 85°C and under the condition of 500 rpm - 1500 rpm, adding the aforementioned liquid A into liquid B and mixing evenly; controlling the temperature below 45°C, adding the aforementioned liquid C, allantoin, dipotassium glycyrrhizinate, surfactant and the remaining humectant, stirring at 500 rpm - 1500 rpm to mix evenly; controlling the temperature below 35°C, adding all the remaining materials, stirring at 500 rpm - 1500 rpm to mix evenly; filtering through a 150 - 300 mesh sieve, discharging, obtaining the composition.

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