Non-irritant skin care composition for repairing skin barrier and gently relieving as well as preparation method and application of skin care composition

Abstract

The invention provides a skin care composition capable of repairing a skin barrier, mildly relieving and non-irritating as well as a preparation method and application of the skin care composition. The skin care composition is prepared from the following raw materials: a plant extract, euglena gracilis polysaccharide, xylitol-based glucoside, hydrolyzed glucosaminoglycan, acetyl dipeptide-1 cetyl ester, ascorbic acid polypeptide, dipropylene glycol, acetyl hexapeptide-8, glyceryl polyether-26, alanine, caprylic / capric triglyceride, hydroxypropyl cyclodextrin, xanthan gum and water. The skin care composition disclosed by the invention can form a protective film, enhance the water locking capacity, protect the stability of various active ingredients, continuously release the active ingredients during use, permeate into skin, supplement intercellular lipid in the inner layer of the skin, effectively inhibit release of inflammatory factors, promote metabolism and renewal of skin cells, and improve the skin care effect. The effects of effectively prolonging and repairing the skin barrier and relieving the skin are achieved, and the effect is mild and non-irritant.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care, and particularly relates to a skin care composition for repairing skin barrier, being mild, soothing and non-irritating, and a preparation method and application thereof. Background Art

[0002] As the largest organ of the human body, the skin is the first line of defense against external environmental stimuli and the invasion of harmful substances. Its barrier function is mainly maintained by the stratum corneum and lipid bilayer structure of the epidermis. In daily life, due to exposure to ultraviolet rays, use of irritating cosmetics, over-cleaning, and environmental pollution, etc., the skin barrier is often damaged, resulting in problems such as skin dryness, desquamation, itching, sensitivity, and flushing, which seriously affect the health and beauty of the skin.

[0003] At present, there are a wide variety of skin care products for repairing skin barrier on the market. However, most of these products still have some deficiencies. On the one hand, in order to pursue quick results, some products add some irritating ingredients such as alcohol. Although it can improve skin symptoms in a short time, long-term use will further damage the skin barrier and aggravate skin problems. In addition, the ingredients of some repair and soothing products are single, relying only on one or two ingredients to play a role, and unable to form a synergistic effect, resulting in poor effect and being difficult to fundamentally improve the skin barrier function. Moreover, although some products are rich in various repair ingredients, the formula design lacks rationality, resulting in possible interactions between ingredients, having a negative impact on the stability and bioavailability of the active ingredients, and thus weakening the expected efficacy of the products. Summary of the Invention

[0004] In view of this, the present invention provides a skin care composition for repairing skin barrier, being mild, soothing and non-irritating, and a preparation method and application thereof. The composition of the present invention contains a variety of natural active ingredients. Through the synergistic effect of each ingredient, it replenishes the moisture and lipid components required by the skin, enhances the skin barrier function, and at the same time adds mild soothing ingredients to reduce skin inflammation and irritation, so as to achieve the repair and care of damaged skin.

[0005] The technical solution of the present invention is realized as follows:

[0006] A skin care composition for repairing skin barrier, mild soothing and non-irritating, comprising the following raw materials in parts by weight: 43-50 parts of plant extract, 3-9 parts of Euglena gracilis polysaccharide, 5-10 parts of xylitol glucoside, 12-18 parts of hydrolyzed glucosaminoglycan, 0.5-1 part of acetyl dipeptide-1 cetyl ester, 0.5-1 part of ascorbic acid polypeptide, 23-30 parts of dipropylene glycol, 5-9 parts of acetyl hexapeptide-8, 7-12 parts of glycerol polyether-26, 1-3 parts of alanine, 10-17 parts of caprylic / capric triglyceride, 3-7 parts of hydroxypropyl cyclodextrin, 4-9 parts of xanthan gum, 180-250 parts of water; the plant extract is one or more of evening primrose extract, scrophularia extract, peony root extract, lotus seed extract, citrus fruit extract, and panax japonicus extract.

[0007] Furthermore, a skin care composition for repairing skin barrier, mild soothing and non-irritating, comprising the following raw materials in parts by weight: 47 parts of plant extract, 8 parts of Euglena gracilis polysaccharide, 10 parts of xylitol glucoside, 14 parts of hydrolyzed glucosaminoglycan, 0.8 part of acetyl dipeptide-1 cetyl ester, 0.6 part of ascorbic acid polypeptide, 27 parts of dipropylene glycol, 8 parts of acetyl hexapeptide-8, 10 parts of glycerol polyether-26, 2 parts of alanine, 16 parts of caprylic / capric triglyceride, 7 parts of hydroxypropyl cyclodextrin, 6 parts of xanthan gum, 180 parts of water.

[0008] Furthermore, the plant extract comprises the following raw materials in parts by weight: 20-27 parts of evening primrose extract, 18-22 parts of scrophularia extract, 14-17 parts of peony root extract, 9-13 parts of lotus seed extract, 9-15 parts of citrus fruit extract, 20-26 parts of panax japonicus extract.

[0009] Furthermore, the plant extract comprises the following raw materials in parts by weight: 25 parts of evening primrose extract, 22 parts of scrophularia extract, 14 parts of peony root extract, 12 parts of lotus seed extract, 14 parts of citrus fruit extract, 23 parts of panax japonicus extract.

[0010] A preparation method of a skin care composition for repairing skin barrier, mild soothing and non-irritating, comprising the following steps:

[0011] S1. Add dipropylene glycol and xanthan gum to water, stir and mix evenly to obtain mixture A;

[0012] S2. Stir and mix evenly acetyl dipeptide-1 cetyl ester, glycerol polyether-26, caprylic / capric triglyceride, and hydroxypropyl cyclodextrin to obtain mixture B;

[0013] S3. Slowly add mixture B to mixture A, then stir and mix evenly. Next, add plant extract, Euglena gracilis polysaccharide, xylitol glucoside, hydrolyzed glucosaminoglycan, ascorbic acid polypeptide, acetyl hexapeptide-8, and alanine, and stir and mix evenly again. After homogenization, cool to room temperature to obtain a skin care composition that can repair the skin barrier, is mild, soothing, and non-irritating.

[0014] Further, in step S1, the temperature of the stirring and mixing is 40 - 50 °C, the stirring speed is 200 - 300 r / min, and the stirring time is 15 - 20 min.

[0015] Further, in step S2, the stirring and mixing is carried out at 40 - 50 °C at a speed of 300 - 400 r / min for 10 - 15 min.

[0016] Further, in step S3, the stirring and mixing is carried out at 40 - 50 °C at a speed of 500 - 600 r / min for 12 - 16 min; the homogenization is carried out at a rotational speed of 2000 - 3000 r / min for 8 - 12 min.

[0017] Use of the skin care composition of the present invention in the preparation of a skin care product for repairing the skin barrier, being mild, soothing, and non-irritating.

[0018] Further, the skin care product includes toner, essence, body lotion, facial cleanser, cream, sunscreen, and facial mask.

[0019] Compared with the prior art, the beneficial effects of the present invention are:

[0020] The skin care composition of the present invention uses plant extracts such as evening primrose extract, scrophularia extract, peony root extract, lotus seed extract, citrus fruit extract, and panax japonicus extract as raw materials, and in combination with raw materials such as Euglena gracilis polysaccharide, xylitol glucoside, hydrolyzed glucosaminoglycan, acetyl dipeptide-1 cetyl ester, ascorbic acid polypeptide, acetyl hexapeptide-8, glycerol polyether-26, and alanine, can form a protective film, enhance the water-locking ability, while protecting the stability of various active ingredients, continuously release active ingredients during use, and can penetrate into the skin, supplement the intercellular lipids in the inner layer of the skin, and can also effectively inhibit the release of inflammatory factors, promote the metabolism and renewal of skin cells, effectively extend the effect of repairing the skin barrier and soothing the skin, and has a mild and non-irritating effect.

[0021] In the present invention, through the synergistic effect of raw materials such as plant extracts, Euglena gracilis polysaccharide, xylitol glucoside, hydrolyzed glucosaminoglycan, ascorbic acid polypeptide, acetyl hexapeptide-8, etc., it can effectively inhibit the excessive release of inflammatory factors, promote the metabolism and renewal of skin cells, relieve sensitive symptoms such as flushing and itching caused by external stimuli, and effectively repair the skin barrier; through the synergistic effect of raw materials such as ascorbic acid polypeptide, dipropylene glycol, glycerol polyether-26, hydroxypropyl cyclodextrin, caprylic / capric triglyceride, etc., the active ingredients in the skin care composition of the present invention can be slowly released and can better penetrate into the skin, so as to achieve the effect of efficiently and durably repairing the skin barrier. Detailed implementation manners

[0022] To better understand the technical content of the present invention, specific examples are provided below to further illustrate the present invention.

[0023] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0024] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can all be obtained from commercial channels.

[0025] The plant extracts of the present invention are as follows: Oenothera biennis extract, Scrophularia ningpoensis extract, Paeonia suffruticosa root extract, Nelumbo nucifera seed extract, Citrus reticulata fruit extract, Panax japonicus extract.

[0026] Example 1

[0027] The skin care composition for repairing the skin barrier, being mild, soothing and non-irritating in this example, comprises the following raw materials in parts by weight: 47 parts of plant extracts, 8 parts of Euglena gracilis polysaccharide, 10 parts of xylitol glucoside, 14 parts of hydrolyzed glucosaminoglycan, 0.8 part of acetyl dipeptide-1 cetyl ester, 0.6 part of ascorbic acid polypeptide, 27 parts of dipropylene glycol, 8 parts of acetyl hexapeptide-8, 10 parts of glycerol polyether-26, 2 parts of alanine, 16 parts of caprylic / capric triglyceride, 7 parts of hydroxypropyl cyclodextrin, 6 parts of xanthan gum, 180 parts of water; the plant extracts are composed of the following raw materials in parts by weight: 25 parts of Oenothera biennis extract, 22 parts of Scrophularia ningpoensis extract, 14 parts of Paeonia suffruticosa root extract, 12 parts of Nelumbo nucifera seed extract, 14 parts of Citrus reticulata fruit extract, 23 parts of Panax japonicus extract.

[0028] The preparation method of the skin care composition for repairing the skin barrier, being mild, soothing and non-irritating in this example, comprises the following steps:

[0029] S1. Add dipropylene glycol and xanthan gum to water, stir at a temperature of 50 °C and a stirring speed of 250 r / min for 16 min to mix evenly, obtaining mixture A;

[0030] S2. Add acetyl dipeptide-1 cetyl ester, glycerol polyether-26, caprylic / capric triglyceride, and hydroxypropyl cyclodextrin, stir at a temperature of 50 °C and a stirring speed of 400 r / min for 12 min to mix evenly, obtaining mixture B;

[0031] S3. Slowly add mixture B to mixture A, then stir at a temperature of 50 °C and a stirring speed of 600 r / min for 15 min to mix evenly, add plant extract, Euglena gracilis polysaccharide, xylitol glucoside, hydrolyzed glucosaminoglycan, ascorbic acid polypeptide, acetyl hexapeptide-8, and alanine, stir at a temperature of 50 °C and a stirring speed of 600 r / min for 12 min to mix evenly again, and then homogenize at a rotation speed of 3000 r / min for 10 min and cool to room temperature, thus obtaining a skin care composition for repairing skin barrier, being mild, soothing and non-irritating.

[0032] Example 2

[0033] The skin care composition for repairing skin barrier, being mild, soothing and non-irritating in this example comprises the following raw materials in parts by weight: 43 parts of plant extract, 6 parts of Euglena gracilis polysaccharide, 9 parts of xylitol glucoside, 16 parts of hydrolyzed glucosaminoglycan, 1 part of acetyl dipeptide-1 cetyl ester, 0.5 part of ascorbic acid polypeptide, 30 parts of dipropylene glycol, 5 parts of acetyl hexapeptide-8, 7 parts of glycerol polyether-26, 3 parts of alanine, 12 parts of caprylic / capric triglyceride, 3 parts of hydroxypropyl cyclodextrin, 9 parts of xanthan gum, and 200 parts of water; the plant extract comprises peony root extract and lotus seed extract in a mass ratio of 3:2.

[0034] The preparation method of the skin care composition for repairing skin barrier, being mild, soothing and non-irritating in this example comprises the following steps:

[0035] S1. Add dipropylene glycol and xanthan gum to water, stir at a temperature of 40 °C and a stirring speed of 300 r / min for 18 min to mix evenly, obtaining mixture A;

[0036] S2. Add acetyl dipeptide-1 cetyl ester, glycerol polyether-26, caprylic / capric triglyceride, and hydroxypropyl cyclodextrin, stir at a temperature of 45 °C and a stirring speed of 350 r / min for 10 min to mix evenly, obtaining mixture B;

[0037] S3. Slowly add mixture B to mixture A, then stir at a temperature of 50 °C and a stirring speed of 500 r / min for 16 min until evenly mixed. Then add plant extract, Euglena gracilis polysaccharide, xylitol glucoside, hydrolyzed glucosaminoglycan, ascorbic acid polypeptide, acetyl hexapeptide-8, and alanine, and stir at a temperature of 50 °C and a stirring speed of 500 r / min for 13 min to mix evenly again. Then homogenize at a rotation speed of 2500 r / min for 12 min and cool to room temperature to obtain a skin care composition for repairing the skin barrier, which is mild, soothing and non-irritating.

[0038] Example 3

[0039] The skin care composition for repairing the skin barrier, which is mild, soothing and non-irritating in this example, comprises the following raw materials in parts by weight: 50 parts of plant extract, 7 parts of Euglena gracilis polysaccharide, 6 parts of xylitol glucoside, 18 parts of hydrolyzed glucosaminoglycan, 0.6 part of acetyl dipeptide-1 cetyl ester, 0.7 part of ascorbic acid polypeptide, 23 parts of dipropylene glycol, 6 parts of acetyl hexapeptide-8, 9 parts of glycerol polyether-26, 1 part of alanine, 14 parts of caprylic / capric triglyceride, 5 parts of hydroxypropyl cyclodextrin, 7 parts of xanthan gum, and 250 parts of water; the plant extract is composed of the following raw materials in parts by weight: 20 parts of evening primrose extract, 18 parts of scrophularia extract, 17 parts of peony root extract, 10 parts of lotus seed extract, 13 parts of citrus fruit extract, and 26 parts of panax japonicus torr. extract.

[0040] The preparation method of the skin care composition for repairing the skin barrier, which is mild, soothing and non-irritating in this example, comprises the following steps:

[0041] S1. Add dipropylene glycol and xanthan gum to water, and stir at a temperature of 45 °C and a stirring speed of 260 r / min for 15 min until evenly mixed to obtain mixture A;

[0042] S2. Add acetyl dipeptide-1 cetyl ester, glycerol polyether-26, caprylic / capric triglyceride, and hydroxypropyl cyclodextrin, and stir at a temperature of 40 °C and a stirring speed of 300 r / min for 14 min until evenly mixed to obtain mixture B;

[0043] S3. Slowly add mixture B to mixture A, then stir at a temperature of 45 °C and a stirring speed of 550 r / min for 15 min until evenly mixed. Then add plant extract, Euglena gracilis polysaccharide, xylitol glucoside, hydrolyzed glucosaminoglycan, ascorbic acid polypeptide, acetyl hexapeptide-8, and alanine, and stir at a temperature of 45 °C and a stirring speed of 550 r / min for 12 min to mix evenly again. Then homogenize at a rotation speed of 2800 r / min for 12 min and cool to room temperature to obtain a skin care composition for repairing the skin barrier, which is mild, soothing and non-irritating.

[0044] Example 4

[0045] The skin care composition for repairing skin barrier, with mild soothing and no irritation, comprises the following raw materials in parts by weight: 45 parts of plant extract, 9 parts of Euglena gracilis polysaccharide, 7 parts of xylitol glucoside, 12 parts of hydrolyzed glucosaminoglycan, 0.7 part of acetyl dipeptide-1 cetyl ester, 1 part of ascorbic acid polypeptide, 28 parts of dipropylene glycol, 9 parts of acetyl hexapeptide-8, 8 parts of glycerol polyether-26, 2.5 parts of alanine, 10 parts of caprylic / capric triglyceride, 6 parts of hydroxypropyl cyclodextrin, 5 parts of xanthan gum, 230 parts of water; the plant extract comprises evening primrose extract, scrophularia extract and citrus fruit extract in a mass ratio of 1:1:1.

[0046] The preparation method of the skin care composition for repairing skin barrier, with mild soothing and no irritation, comprises the following steps:

[0047] S1. Add dipropylene glycol and xanthan gum into water, stir at a temperature of 50 °C and a stirring speed of 280 r / min for 20 min to mix evenly, obtaining mixture A;

[0048] S2. Add acetyl dipeptide-1 cetyl ester, glycerol polyether-26, caprylic / capric triglyceride and hydroxypropyl cyclodextrin, stir at a temperature of 50 °C and a stirring speed of 400 r / min for 15 min to mix evenly, obtaining mixture B;

[0049] S3. Slowly add mixture B into mixture A, then stir at a temperature of 50 °C and a stirring speed of 560 r / min for 14 min to mix evenly, add plant extract, Euglena gracilis polysaccharide, xylitol glucoside, hydrolyzed glucosaminoglycan, ascorbic acid polypeptide, acetyl hexapeptide-8 and alanine, stir at a temperature of 50 °C and a stirring speed of 560 r / min for 16 min to mix evenly again, then homogenize at a rotation speed of 2000 r / min for 8 min and cool to room temperature, thus obtaining the skin care composition for repairing skin barrier, with mild soothing and no irritation.

[0050] Comparative Example 1

[0051] The difference between this comparative example and Example 1 is that the raw material ratio of the target skin care composition is changed, and the rest is the same as that of Example 1.

[0052] The skin care composition for repairing skin barrier, being mild, soothing and non-irritating in this comparative example comprises raw materials in the following parts by weight: 21 parts of plant extract, 8 parts of Euglena gracilis polysaccharide, 9 parts of xylitol glucoside, 23 parts of hydrolyzed glucosaminoglycan, 2 parts of acetyl dipeptide-1 cetyl ester, 3 parts of ascorbic acid polypeptide, 18 parts of dipropylene glycol, 2 parts of acetyl hexapeptide-8, 30 parts of glycerol polyether-26, 9 parts of alanine, 12.4 parts of caprylic / capric triglyceride, 9 parts of hydroxypropyl cyclodextrin, 10 parts of xanthan gum, 180 parts of water.

[0053] Comparative Example 2

[0054] The difference between this comparative example and Example 1 lies in that the raw materials of the target skin care composition do not contain plant extract, and the rest are the same as those in Example 1.

[0055] The skin care composition for repairing skin barrier, being mild, soothing and non-irritating in this comparative example comprises raw materials in the following parts by weight: 8 parts of Euglena gracilis polysaccharide, 10 parts of xylitol glucoside, 20 parts of hydrolyzed glucosaminoglycan, 0.8 part of acetyl dipeptide-1 cetyl ester, 0.6 part of ascorbic acid polypeptide, 32 parts of dipropylene glycol, 14 parts of acetyl hexapeptide-8, 16 parts of glycerol polyether-26, 8 parts of alanine, 22 parts of caprylic / capric triglyceride, 13 parts of hydroxypropyl cyclodextrin, 12 parts of xanthan gum, 180 parts of water.

[0056] Comparative Example 3

[0057] The difference between this comparative example and Example 1 lies in that the raw materials of the target skin care composition do not contain Euglena gracilis polysaccharide and xylitol glucoside, and the rest are the same as those in Example 1.

[0058] The skin care composition for repairing skin barrier, being mild, soothing and non-irritating in this comparative example comprises raw materials in the following parts by weight: 47 parts of plant extract, 24 parts of hydrolyzed glucosaminoglycan, 0.8 part of acetyl dipeptide-1 cetyl ester, 0.6 part of ascorbic acid polypeptide, 27 parts of dipropylene glycol, 4 parts of acetyl hexapeptide-8, 14 parts of glycerol polyether-26, 2 parts of alanine, 16 parts of caprylic / capric triglyceride, 7 parts of hydroxypropyl cyclodextrin, 6 parts of xanthan gum, 180 parts of water.

[0059] Comparative Example 4

[0060] The difference between this comparative example and Example 1 lies in that the raw materials of the target skin care composition do not contain hydrolyzed glucosaminoglycan, and the rest are the same as those in Example 1.

[0061] The skin care composition for repairing skin barrier, being mild, soothing and non-irritating in this comparative example comprises raw materials in the following parts by weight: 47 parts of plant extract, 8 parts of euglena gracilis polysaccharide, 10 parts of xylitol glucoside, 0.8 part of acetyl dipeptide-1 cetyl ester, 0.6 part of ascorbic acid polypeptide, 29 parts of dipropylene glycol, 10 parts of acetyl hexapeptide-8, 12 parts of glycerol polyether-26, 4 parts of alanine, 18 parts of caprylic / capric triglyceride, 9 parts of hydroxypropyl cyclodextrin, 8 parts of xanthan gum, and 180 parts of water.

[0062] Comparative Example 5

[0063] The difference between this comparative example and Example 1 lies in that the raw materials of the target skin care composition do not contain ascorbic acid polypeptide and dipropylene glycol, and the rest are the same as those in Example 1.

[0064] The skin care composition for repairing skin barrier, being mild, soothing and non-irritating in this comparative example comprises raw materials in the following parts by weight: 52 parts of plant extract, 8 parts of euglena gracilis polysaccharide, 10 parts of xylitol glucoside, 19 parts of hydrolyzed glucosaminoglycan, 1.4 parts of acetyl dipeptide-1 cetyl ester, 15 parts of glycerol polyether-26, 7 parts of alanine, 21 parts of caprylic / capric triglyceride, 12 parts of hydroxypropyl cyclodextrin, 11 parts of xanthan gum, and 180 parts of water.

[0065] Test Example

[0066] Performance effect tests were conducted on the skin care compositions for repairing skin barrier, being mild, soothing and non-irritating prepared in the above Examples 1-4 and Comparative Examples 1-5.

[0067] Sixty ICR mice, half male and half female, of SPF grade with a body weight of 20±2 g were taken and divided into a normal group of 6 mice and a model group of 54 mice. The back hair of the mice in the normal group and the model group was removed. Except for the normal group, the mice in the model group were used to replicate the skin mechanical barrier function damage model by the tape method, that is, medical tape was closely attached to the back skin of the mice with the back hair shaved off, and then quickly torn off for modeling stimulation. This was done 2 times a day, and each stimulation repeated the steps of "tape sticking - tearing off" 5 times. The time interval between the two modeling stimulations was 8 h, and the modeling was carried out continuously for 3 days. After modeling, the back skin of the mice showed a state of skin swelling and obvious bleeding.

[0068] The model group mice after modeling were randomly divided into 9 groups, with 6 mice in each group. The mice in the 1st - 9th groups after modeling were respectively applied with the skin care compositions for repairing skin barrier, being mild, soothing and non-irritating prepared in Examples 1-4 and Comparative Examples 1-5 on the damaged parts of the skin mechanical barrier function of the mice, with a dosage of 0.3 g / mouse, and gently massaged until absorbed. After continuous use for 5 days, 24 h after the last application, the skin moisture condition and the epidermal thickness condition of the mice in each group were measured.

[0069] Skin moisture measurement: 24 hours after the last application of the skin care composition, under the conditions of a room temperature of 22 - 25°C and a relative air humidity of 50% - 60%, the skin hydration content of the back skin of mice was measured using a MoistureMeter SC Compact measuring instrument. During the detection process, the instrument was in full contact with the skin and kept in a vertical state. The same measurement site was measured 3 times, and the results were averaged. The results are shown in Table 1 below.

[0070] Epidermal thickness: 24 hours after the last application of the skin care composition, the back skin of mice in each group was taken, fixed with formalin, and then the skin tissue was fixed, sectioned, and stained. The sections were placed under an upright microscope, and a field of view was randomly selected to measure the epidermal thickness. The measurement was repeated 3 times, and the results were averaged. The results are shown in Table 1 below.

[0071] Skin tissue morphology: 24 hours after the last application of the skin care composition, the tissue states of the modeled mice in each group were observed and recorded. The results are shown in Table 1 below.

[0072] Table 1 Effects of the skin care composition on the damage of the mechanical barrier function of mouse skin

[0073] Skin hydration degree (unit) Epidermal thickness / (μm) Example 1 40.13 36.49 Example 2 38.65 37.10 Example 3 39.82 36.59 Example 4 38.39 37.24 Comparative Example 1 35.80 40.48 Comparative Example 2 29.47 47.36 Comparative Example 3 32.43 43.79 Comparative Example 4 31.86 42.52 Comparative Example 5 30.27 45.16 Normal group 63.85 12.37

[0074] From the above results, it can be seen that compared with Example 1, the unreasonable raw material ratio of the skin care composition in Comparative Example 1 led to a weakening of the synergistic effect between the active ingredients, and the effects of maintaining skin moisture content and promoting wound healing were reduced. Compared with Example 1, Comparative Example 2 did not contain plant extracts, Comparative Example 3 did not contain Euglena gracilis polysaccharide and xylitol glucoside, Comparative Example 4 did not contain hydrolyzed glucosaminoglycan, and Comparative Example 5 did not contain ascorbic acid polypeptide and dipropylene glycol, resulting in a reduced effect of promoting the repair of the skin barrier. The above results show that the skin care compositions prepared in Examples 1 - 4 of the present invention, through the combined use of raw materials such as plant extracts, Euglena gracilis polysaccharide, xylitol glucoside, hydrolyzed glucosaminoglycan, ascorbic acid polypeptide, and dipropylene glycol, can protect the stability of various active ingredients, enable the active ingredients to penetrate deep into the skin and be continuously released, supplement the intercellular lipids in the inner layer of the skin, enhance the water-locking ability, promote the better absorption and utilization of the active ingredients by the skin, effectively promote the metabolism and renewal of skin cells, relieve sensitive symptoms such as flushing and itching caused by external stimuli, improve the repair effect of the damaged skin barrier, and also effectively promote the healing of damaged skin, resulting in a decrease in skin thickness.

[0075] Take HaCaT cells at a density of 3.0×10 5Inoculate into a 12-well plate at a density of

[0076] Table 2 Effects of the skin care composition on inflammatory factors

[0077]

[0078]

[0079] The above results show that, compared with the skin care compositions of Comparative Examples 1-5, the skin care compositions prepared in Examples 1-4 of the present invention exhibit good effects in reducing inflammatory factors IL-6 and IL-8. It shows that through the reasonable raw material ratio and the combined use of active substances such as plant extracts, Euglena gracilis polysaccharide, xylitol glucoside, hydrolyzed glucosaminoglycan, ascorbic acid polypeptide, and dipropylene glycol in the present invention, the production of inflammatory factors can be effectively inhibited, the skin inflammation can be effectively alleviated, and thus the repair of the skin barrier can be effectively promoted.

[0080] In addition, when the skin care compositions prepared in Examples 1-4 of the present invention are used in the sensitization experiment of albino guinea pigs, there are no obvious changes in the guinea pigs, and no erythema or edema is found in the guinea pigs, indicating that the skin care composition of the present invention can soothe damaged skin while being mild and non-irritating.

[0081] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A skin care composition for repairing skin barrier, which is mild, soothing and non-irritating, characterized in that, It comprises the following raw materials in parts by weight: 43 - 50 parts of plant extract, 3 - 9 parts of euglena gracilis polysaccharide, 5 - 10 parts of xylitol glucoside, 12 - 18 parts of hydrolyzed glucosaminoglycan, 0.5 - 1 part of acetyl dipeptide - 1 cetyl ester, 0.5 - 1 part of ascorbic acid polypeptide, 23 - 30 parts of dipropylene glycol, 5 - 9 parts of acetyl hexapeptide - 8, 7 - 12 parts of glycerol polyether - 26, 1 - 3 parts of alanine, 10 - 17 parts of caprylic / capric triglyceride, 3 - 7 parts of hydroxypropyl cyclodextrin, 4 - 9 parts of xanthan gum, 180 - 250 parts of water; the plant extract is one or more of evening primrose extract, scrophularia extract, peony root extract, lotus seed extract, citrus fruit extract, and panax japonicus extract.

2. The skin care composition for repairing skin barrier, being mild, soothing and non-irritating according to claim 1, wherein It comprises the following raw materials in parts by weight: 47 parts of plant extract, 8 parts of euglena gracilis polysaccharide, 10 parts of xylitol glucoside, 14 parts of hydrolyzed glucosaminoglycan, 0.8 part of acetyl dipeptide - 1 cetyl ester, 0.6 part of ascorbic acid polypeptide, 27 parts of dipropylene glycol, 8 parts of acetyl hexapeptide - 8, 10 parts of glycerol polyether - 26, 2 parts of alanine, 16 parts of caprylic / capric triglyceride, 7 parts of hydroxypropyl cyclodextrin, 6 parts of xanthan gum, 180 parts of water.

3. The skin care composition for repairing skin barrier, which is mild, soothing and non-irritating according to claim 1, is characterized in that, The plant extract comprises the following raw materials in parts by weight: 20 - 27 parts of evening primrose extract, 18 - 22 parts of scrophularia extract, 14 - 17 parts of peony root extract, 9 - 13 parts of lotus seed extract, 9 - 15 parts of citrus fruit extract, 20 - 26 parts of panax japonicus extract.

4. The skin care composition for repairing skin barrier, which is mild, soothing and non-irritating according to claim 1, is characterized in that, The plant extract comprises the following raw materials in parts by weight: 25 parts of evening primrose extract, 22 parts of scrophularia extract, 14 parts of peony root extract, 12 parts of lotus seed extract, 14 parts of citrus fruit extract, 23 parts of panax japonicus extract.

5. A method for preparing the skin care composition for repairing skin barrier, being mild, soothing and non-irritating according to any one of claims 1-4, characterized in that, It comprises the following steps: S1. Add dipropylene glycol and xanthan gum to water, stir and mix evenly to obtain mixture A. S2. Stir and mix acetyl dipeptide - 1 cetyl ester, glycerol polyether - 26, caprylic / capric triglyceride, and hydroxypropyl cyclodextrin evenly to obtain mixture B. S3. Slowly add mixture B to mixture A, then stir and mix evenly, and then add plant extract, euglena gracilis polysaccharide, xylitol glucoside, hydrolyzed glucosaminoglycan, ascorbic acid polypeptide, acetyl hexapeptide - 8, and alanine and stir and mix evenly again. After homogenization, cool to room temperature to obtain a skin care composition for repairing skin barrier, which is mild, soothing and non - irritating.

6. The preparation method of the skin care composition for repairing skin barrier, being mild, soothing and non-irritating according to claim 1, characterized in that In step S1, the temperature of the stirring and mixing is 40 - 50 °C, the stirring speed is 200 - 300 r / min, and the stirring time is 15 - 20 min.

7. The preparation method of the skin care composition for repairing skin barrier, being mild, soothing and non-irritating according to claim 1, characterized in that In step S2, the stirring and mixing is carried out at 40 - 50 °C at a speed of 300 - 400 r / min for 10 - 15 min.

8. The preparation method of the skin care composition for repairing skin barrier, being mild, soothing and non-irritating according to claim 1, characterized in that In step S3, the stirring and mixing is carried out at 40 - 50 °C at a speed of 500 - 600 r / min for 12 - 16 min; the homogenization is carried out at a rotation speed of 2000 - 3000 r / min for 8 - 12 min.

9. Use of the skin care composition according to any one of claims 1-4 or the skin care composition prepared by the preparation method according to any one of claims 5-8 in the preparation of a skin care product for repairing the skin barrier, being mild, soothing and non-irritating.

10. The application according to claim 9, wherein The skin care products include toner, essence, body lotion, sunscreen, and facial mask.

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