Pseudo-ginseng composition with facial itching relieving and moisturizing effects

Abstract

In order to solve the problems existing in the prior art, the invention provides a pseudo-ginseng composition with facial itching relieving and moisturizing effects, which comprises the following components in parts by mass: 100 parts of a matrix component, 0.1-0.5 part of sodium hyaluronate and / or hyaluronic acid and 1-3 parts of an additive component. The matrix component is a mixture of 5-10wt% of glycerol and the balance of water in percentage by mass. The additive is prepared from the following components in parts by mass: 10 to 100 parts of radix notoginseng extract, 10 to 60 parts of radix ginseng extract, 10 to 60 parts of radix ophiopogonis extract and 10 to 50 parts of apple extract. According to the invention, the additive components are added, so that the lasting moisturizing capacity of a classical moisturizing agent such as glycerol, sodium hyaluronate and / or hyaluronic acid and water on the face can be remarkably improved. The addition of the additive components can also play a very good role in relieving itching caused by dry skin or skin inflammation.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and particularly relates to a notoginseng composition with facial itching-relieving and moisturizing effects. Background Art

[0002] The skin is the largest organ of the human body. It not only plays a role in protecting internal organs but also participates in important functions such as body temperature regulation and sensory transmission. If the skin lacks moisture, problems such as dryness, roughness, and even peeling and cracking will occur. Moreover, dry skin will also lead to a thinner stratum corneum, making nerve endings more easily stimulated and causing itching, and in severe cases, skin chapping and other problems will occur. In addition, moisturizing is also one of the important measures to prevent skin aging.

[0003] Using cosmetics with moisturizing functions is a very common moisturizing method nowadays. Among them, preparations obtained by compounding glycerol, hyaluronic acid or sodium hyaluronate with water are the most common moisturizers. However, this classic formulation has a relatively obvious problem of short moisturizing duration when moisturizing the face. The main reason is that compared with the hands, the face is exposed to the external environment for a long time over a large area, which is more likely to cause the volatilization of skin moisture. And due to less movement on the face, the ability to maintain the skin moisture content through its own metabolism is also significantly weaker than that of the hands that often move. Summary of the Invention

[0004] To solve the problem of relatively short facial moisturizing time of existing moisturizers in the prior art, the present invention provides a notoginseng composition with facial itching-relieving and moisturizing effects. Calculated by mass parts, it includes: 100 parts of a matrix component, 0.1 - 0.5 part of sodium hyaluronate and / or hyaluronic acid, and 1 - 3 parts of an additive component. Calculated by mass percentage, the matrix component is a mixture of 5 - 10 wt.% of glycerol and the balance of water.

[0005] Calculated by mass parts, the additive component includes: 10 - 100 parts of notoginseng extract, 10 - 60 parts of ginseng extract, 10 - 60 parts of ophiopogon japonicus extract, and 10 - 50 parts of apple extract.

[0006] Further, calculated by mass parts, the additive component includes: 40 - 50 parts of notoginseng extract, 30 - 40 parts of ginseng extract, 15 - 20 parts of ophiopogon japonicus extract, and 20 - 25 parts of apple extract.

[0007] Further, the apple extract is prepared by the following method: First, wash fresh apples with skins, cut them into pieces, and immerse them in absolute ethanol with a mass 4 times that of the apples.

[0008] Then, perform cyclic extraction at a temperature of 35 - 45 °C for 40 - 80 minutes.

[0009] Finally, perform filtration and separation, take the filtrate part, dry it under negative pressure at 30 - 40 °C, and then crush the dried product to a particle size less than or equal to 200 mesh to obtain the apple extract.

[0010] Furthermore, the particle sizes of the notoginseng extract, ginseng extract, and ophiopogon japonicus extract are all less than or equal to 300 mesh.

[0011] Furthermore, the additive component further includes: 1 - 20 parts of a composite component. The composite component at least includes at least one of cinnamon extract and schisandra chinensis extract.

[0012] Furthermore, the composite component includes: 6 parts of cinnamon extract and 4 parts of schisandra chinensis extract, and the addition amount of the composite component is 40 - 55% of the mass of the apple extract.

[0013] Furthermore, the particle sizes of the cinnamon extract and the schisandra chinensis extract are less than or equal to 300 mesh.

[0014] Furthermore, the composition is prepared by the following method: Step 1 Add the formulated amount of the additive component to the formulated amount of water, stir at room temperature for 20 minutes to obtain mixture A. Add the formulated amount of sodium hyaluronate and / or hyaluronic acid to the formulated amount of glycerol, and stir well to obtain mixture B.

[0015] Step 2 Gradually add mixture B to mixture A under stirring.

[0016] Step 3 After the addition, stir until evenly mixed to obtain the notoginseng composition with the facial antipruritic and moisturizing effects.

[0017] Furthermore, after adding the formulated amount of the additive component to the formulated amount of water in Step 1, stir and process for 3 minutes in a 2450 MHz microwave field at 25 - 30 °C to obtain mixture A.

[0018] Furthermore, it also includes 0.1 - 0.3 parts of phenoxyethanol and 0.1 - 1.0 parts of aroma components.

[0019] The beneficial effects of the present invention are as follows: 1. By adding the additive component, the present invention can significantly improve the long - term moisturizing ability of the classic moisturizers such as glycerol, sodium hyaluronate and / or hyaluronic acid, and water on the face.

[0020] 2. The addition of the additive component of the present invention can also play a very good antipruritic role against itching caused by skin dryness or skin inflammation. Description of the Drawings

[0021] Figure 1The line graph shows the test results of the moisturizing time of the composition with different addition amounts of apple extract, quercetin, apple peel extract, onion outer skin extract, and blueberry extract added to the additive of the present invention.

[0022] Figure 2 The line graph shows the test results of the moisturizing time of the composition with different addition amounts of apple extract added to the additive of the present invention.

[0023] Figure 3 The line graph shows the test results of the moisturizing time of the composition with different addition amounts of quercetin added to the additive of the present invention.

[0024] Figure 4 The line graph shows the test results of the moisturizing time of the composition with different addition amounts of apple peel extract added to the additive of the present invention.

[0025] Figure 5 The line graph shows the test results of the moisturizing time of the composition with different addition amounts of onion outer skin extract added to the additive of the present invention.

[0026] Figure 6 The line graph shows the test results of the moisturizing time of the composition with different addition amounts of blueberry extract added to the additive of the present invention.

[0027] Figure 7 The line graph shows the test results of the itching relief onset time of the composition with different addition amounts of schisandra chinensis extract, cinnamon extract, or a mixture of schisandra chinensis extract and cinnamon extract in equal mass ratio added to the additive of the present invention.

[0028] Figure 8 The line graph shows the test results of the itching relief onset time of the composition with different addition amounts when the cinnamon extract in the mixture of schisandra chinensis extract and cinnamon extract in equal mass ratio is replaced with mugwort leaf extract in equal mass in the additive of the invention.

[0029] Figure 9 The line graph shows the test results of the itching relief onset time of the composition with different addition amounts when the schisandra chinensis extract in the mixture of schisandra chinensis extract and cinnamon extract in equal mass ratio is replaced with mugwort leaf extract in equal mass in the additive of the invention.

[0030] Figure 10 The line graph shows the test results of the moisturizing time of the composition with schisandra chinensis extract, cinnamon extract, or a mixture of schisandra chinensis extract and cinnamon extract in equal mass ratio added to the additive of the present invention. Detailed implementation manners

[0031] Exemplary embodiments will be described in detail herein. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. On the contrary, they are merely examples of apparatuses and methods consistent with some aspects of the present application as detailed in the appended claims.

[0032] The terms used in the present application are for the purpose of describing particular embodiments only and are not intended to limit the present application. The singular forms "a", "the", and "said" used in the present application and the appended claims are also intended to include the plural forms unless the context clearly dictates otherwise. It should also be understood that the term "and / or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.

[0033] It should be understood that although the terms first, second, third, etc. may be used in the present application to describe various information, such information should not be limited to these terms. These terms are only used to distinguish the same type of information from each other. For example, without departing from the scope of the present application, the first information may also be referred to as the second information, and similarly, the second information may also be referred to as the first information. Depending on the context, the word "if" as used herein may be interpreted as "when" or "while" or "in response to a determination".

[0034] The present invention will be described in detail below. Without conflict, the features in the following embodiments and implementation manners may be combined with each other.

[0035] The present invention exemplarily provides a notoginseng composition having the efficacy of relieving itching and moisturizing the face. Calculated by mass parts, it includes: 100 parts of a matrix component, 0.1 - 0.5 part of sodium hyaluronate and / or hyaluronic acid, and 1 - 3 parts of an additive component. Calculated by mass percentage, the matrix component is a mixture of 5 - 10 wt.% of glycerol and the balance of water.

[0036] Calculated by mass parts, the additive component includes: 10 - 100 parts of notoginseng extract, 10 - 60 parts of ginseng extract, 10 - 60 parts of ophiopogon japonicus extract, and 10 - 50 parts of apple extract.

[0037] The present invention exemplarily provides an apple extract, and the apple extract is prepared by the following method: First, wash the fresh apples with the skin on, cut them into pieces, and immerse them in 4 times the mass of absolute ethanol.

[0038] Then, perform cyclic extraction at a temperature of 35 - 45 °C for 40 - 80 minutes.

[0039] Finally, filter and separate, take the filtrate part, perform negative pressure drying at 30 - 40 °C, and then crush the dried product to a particle size less than or equal to 200 mesh to obtain the apple extract.

[0040] Glycerin, water, sodium hyaluronate and / or hyaluronic acid are a very classic moisturizing formula. Most of the current cosmetics with moisturizing effects adopt this classic formula. Among them, glycerin has multiple hydroxyl functional groups in its molecular structure, and the hydroxyl functional groups can adsorb water molecules to form hydrogen bonds. Therefore, glycerin can absorb moisture in the air on the one hand and prevent the evaporation of moisture in the skin on the other hand. The moisturizing principle of sodium hyaluronate and hyaluronic acid mainly lies in that they belong to mucopolysaccharide substances and have very strong water absorption ability. Among them, sodium hyaluronate is more stable than hyaluronic acid. The acidity of hyaluronic acid can dissolve the stratum corneum. The molecular weight of sodium hyaluronate is generally smaller and it is easier to penetrate into the deep layer of the skin. This classic formula has a good moisturizing effect, but the moisturizing time is relatively short, generally not exceeding 4 hours. Especially when used for facial moisturizing, the moisturizing time will be shorter, generally not exceeding 3 hours.

[0041] Wenshan City, Yunnan Province is the main planting area of Panax notoginseng. It is reported that when Panax notoginseng is used externally, it has the effects of stopping bleeding, dispersing stasis, detumescence and relieving pain. The extracts of Panax notoginseng contain active ingredients such as saponins and flavonoids, and these substances have the effects of anti-inflammatory, antioxidant and promoting cell repair, thus alleviating the symptoms of skin itching.

[0042] It is reported that ginseng extract has: Moisturizing: The active ingredients in ginseng can promote the hydration of the skin, increase the water content of the skin, and thus achieve a moisturizing effect.

[0043] Antioxidation: Components such as polysaccharides and saponins in ginseng have antioxidant effects, can neutralize free radicals, and protect the skin from oxidative damage.

[0044] Promoting skin repair: Ginsenosides in ginseng have anti-inflammatory and cell protection effects, can reduce inflammatory reactions, and thus promote skin repair.

[0045] Anti-aging: Multiple active ingredients in ginseng such as ginsenosides and polysaccharides can inhibit the generation of free radicals, improve the antioxidant capacity of the skin, and delay the aging process.

[0046] Whitening: Some studies believe that certain components in ginseng may have the effect of inhibiting melanin synthesis, and thus achieve a certain whitening effect.

[0047] Improving uneven skin tone: Certain compounds in ginseng can regulate epidermal pigment metabolism and effectively relieve the phenomenon of uneven skin tone caused by reasons such as endocrine disorders.

[0048] Enhancing the water retention ability of the skin: Amino acids and trace elements in ginseng can promote the formation of the stratum corneum, enhance the skin barrier function, and thus improve the water retention ability of the skin.

[0049] It is reported that the extracts of Ophiopogon japonicus have the following effects: Moisturizing: The extracts of Ophiopogon japonicus can penetrate deep into the skin, increase the water content of the stratum corneum, form a protective film to lock in moisture, and keep the skin moisturized and plump.

[0050] Antioxidation: It has strong antioxidant ability, can effectively fight against the damage of free radicals to the skin, delay skin aging, and maintain youthful vitality.

[0051] Anti-aging: The extracts of Ophiopogon japonicus can promote the synthesis of collagen and cell regeneration, significantly improve the elasticity and gloss of the skin, and make the skin glow with healthy luster.

[0052] Whitening: The flavonoid compounds contained in Ophiopogon japonicus can inhibit the synthesis of melanin, thus achieving the effect of whitening the skin.

[0053] Soothe and anti-allergy: It has the ability to soothe skin inflammation, relieve skin discomfort, and provide gentle care for the skin.

[0054] The applicant added the extracts of Panax notoginseng, Panax ginseng, and Ophiopogon japonicus to the classic formula of glycerin, water, sodium hyaluronate, and / or hyaluronic acid to obtain a Panax notoginseng composition with moisturizing and antipruritic effects. At this time, glycerin, water, sodium hyaluronate, and / or hyaluronic acid in the composition mainly play a moisturizing role, the extract of Panax notoginseng mainly has an antipruritic effect, and the extracts of Panax ginseng and Ophiopogon japonicus improve the moisturizing effect of the composition, but the improvement effect on the facial moisturizing time is not obvious.

[0055] Accidentally, the applicant found that adding apple puree would significantly increase the moisturizing time of the above-mentioned Panax notoginseng composition with moisturizing and antipruritic effects. However, the addition of apple puree would affect the feel when applying the composition. Therefore, the applicant separately tried to extract apples using water and ethanol as solvents and found through separate experiments that compared with the water extract of apples, the ethanol extract of apples had a very significant promoting effect on the moisturizing time of the Panax notoginseng composition of the present invention. This may be because the ethanol extract of apples is rich in quercetin. It is reported that about 20 mg of quercetin is contained in every 100 g of apple peel, and quercetin has good moisturizing and anti-inflammatory effects when used externally. The reasons are as follows: 1. The molecular structure of quercetin contains multiple hydroxyl groups, so quercetin has good water absorption, and thus can lock in the moisture in the skin well.

[0056] 2. The molecular structure of quercetin is stable. When used for facial moisturizing, it can effectively resist the complex external environment that the face contacts for a long time, thereby prolonging the moisturizing time.

[0057] 3. Quercetin can relieve skin inflammatory reactions by regulating the release of inflammatory mediators, thus playing a certain role in reducing inflammation and itching.

[0058] Therefore, the applicant conducted tests by substituting quercetin with an equal amount of apple additive and found that in most cases, adding quercetin did improve the moisturizing time of the Panax notoginseng composition of the present invention, but the effect was weaker than that of adding apple extract. It can be seen that the addition of apple additive does not simply improve the moisturizing time by increasing the moisturizing component quercetin. Moreover, the price of quercetin is much higher than that of apple extract. Therefore, using apple extract can not only improve the efficacy of the composition but also significantly reduce the preparation cost.

[0059] In addition, the applicant also tried: adding only apple extract without adding Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract. The moisturizing time of the composition was slightly longer than that of the composition without other additives, but significantly weaker than that of the composition adding only quercetin. Adding only ginseng extract and apple extract, compared with adding only ginseng extract, the moisturizing time of the composition was slightly improved, but significantly weaker than that of the composition adding quercetin and ginseng extract. Adding only Ophiopogon japonicus and apple extract, compared with adding only Ophiopogon japonicus, the moisturizing time of the composition was slightly improved, but significantly weaker than that of the composition adding quercetin and Ophiopogon japonicus. Only when adding Panax notoginseng extract, ginseng extract, Ophiopogon japonicus extract, and apple extract simultaneously, a relatively obvious increase in moisturizing time would occur. It can be seen that the addition of apple extract mainly improves the moisturizing time of the Panax notoginseng composition of the present invention through the synergistic effect with Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract.

[0060] The present invention exemplarily provides an additive component, in parts by mass, including: 40 - 50 parts of Panax notoginseng extract, 30 - 40 parts of ginseng extract, 15 - 20 parts of Ophiopogon japonicus extract, and 20 - 25 parts of apple extract.

[0061] The applicant found through research that in a specific ratio, the effect of adding apple extract would show an unexpected surge, while this phenomenon did not occur when directly adding quercetin. This also shows that the substances playing a synergistic role in apple extract are not only quercetin but also other component substances. However, due to the complex components in apple extract, it is impossible to clarify which specific extract takes effect. Therefore, the applicant extracted and compared other plants rich in quercetin to further determine whether this phenomenon exists only in apple extract.

[0062] It is reported that quercetin in apples is mainly enriched in the peel. In addition, the plant with the highest quercetin content is the outer skin of onions, and the quercetin content in blueberries is also very high. Therefore, the applicant used equal masses of apple peel, onion outer skin, and blueberries as extraction targets, and obtained extracts by the same alcohol extraction method as the apple extract of the present invention, and added them to the notoginseng composition of the present invention. It was found that the improvement effect of the moisturizing time of the apple peel extract, onion outer skin extract, and blueberry extract was weaker than that of the same amount of quercetin additive, and there was no phenomenon of a sharp increase in the effect without specific components. This also reversely proves that a certain alcohol-extracted biological substance in apples, together with quercetin, has a synergistic effect with the notoginseng composition of the present invention, resulting in a significant improvement in the moisturizing time of the notoginseng composition.

[0063] The present invention exemplarily provides a notoginseng extract, a ginseng extract, and an ophiopogon japonicus extract, and the particle sizes of the notoginseng extract, ginseng extract, and ophiopogon japonicus extract are less than or equal to 300 mesh. At this particle size, there is no obvious foreign matter or granular feeling when the composition is applied, and notoginseng, ginseng, and ophiopogon japonicus achieve a cell wall-breaking effect, enabling the human skin to better absorb their active ingredients.

[0064] The present invention exemplarily provides an additive component, further comprising: 1-20 parts of a composite component. The composite component at least comprises: at least one of a cinnamon extract and a schisandra chinensis extract.

[0065] When the schisandra chinensis extract is used externally, it has the effects of hemostasis, antibacterial and anti-inflammatory, clearing heat and detoxifying, and detumescence and pain relief. When the cinnamon extract is used externally, it has the effects of clearing heat and detoxifying, and dispersing wind and heat. Therefore, when at least one of the cinnamon extract and the schisandra chinensis extract is added to the notoginseng composition of the present invention, the itching relief effect of the composition can be effectively improved, especially the onset time of itching relief can be significantly shortened.

[0066] The present invention exemplarily provides a composite component, the composite component comprises: 6 parts of a cinnamon extract and 4 parts of a schisandra chinensis extract, and the addition amount of the composite component is 40-55% of the mass of the apple extract.

[0067] The applicant's research found that when the cinnamon extract and the schisandra chinensis extract are added as an itching relief complex to the notoginseng composition containing the apple extract, the itching relief effect of the composition is improved, but the moisturizing time decreases to a certain extent. This may be because the added cinnamon extract and schisandra chinensis extract affect the synergistic effect between the apple extract and the notoginseng and ginseng extracts, resulting in a weakened improvement effect on the moisturizing time. However, under the specific addition amount and components of the composite component exemplified in the present invention, the added cinnamon extract and schisandra chinensis extract not only retain the improvement effect on itching relief, but also no longer have a negative impact on the moisturizing effect.

[0068] The present invention exemplarily provides a cinnamon extract and a schisandra chinensis extract, and the particle sizes of the cinnamon extract and the schisandra chinensis extract are less than or equal to 300 mesh. At this particle size, there is no obvious foreign matter or granular feeling when the composition is applied, and the cinnamon extract and the schisandra chinensis extract achieve a cell wall breaking effect, enabling the human skin to better absorb their active ingredients.

[0069] The present invention exemplarily provides a preparation method of the composition of the present invention, including: Step 1: Add the additive components in the formula amount to the water in the formula amount, and stir at room temperature for 20 minutes to obtain a mixed solution A. Add the sodium hyaluronate and / or hyaluronic acid in the formula amount to the glycerol in the formula amount, and stir well to obtain a mixed solution B.

[0070] Step 2: Gradually add the mixed solution B to the mixed solution A under stirring.

[0071] Step 3: After the addition is completed, stir until evenly mixed to obtain the panax notoginseng composition with the facial itching-relieving and moisturizing effects.

[0072] The composition obtained by this method has the components evenly mixed, and the product has good stability, and can effectively achieve the effects of the composition of the present invention.

[0073] The present invention exemplarily provides an improved preparation method of the composition of the present invention. In step 1, after adding the additive components in the formula amount to the water in the formula amount, stir and process in a 2450 MHz microwave field at 25 - 30 °C for 3 minutes to obtain a mixed solution A.

[0074] Using this method can significantly shorten the stirring time of step 1, and after microwave treatment, the active substances of each component additive are fully released into the water solvent, thereby significantly improving the onset time of the composition of the present invention.

[0075] The present invention exemplarily provides a panax notoginseng composition with the facial itching-relieving and moisturizing effects. In addition to the above components, it further includes 0.1 - 0.3 parts of phenoxyethanol and 0.1 - 1.0 part of an aroma component. Among them, phenoxyethanol is mainly used as a preservative, and the aroma component is mainly used to adjust the aroma of the composition.

[0076] The following further illustrates the technical effects of the present invention in combination with specific embodiments.

[0077] The present invention uses the following method to detect the moisturizing performance of the composition product: With reference to QB / T 4256-2011 "Guidelines for Evaluation of Moisturizing Efficacy of Cosmetics", 20 testers were selected for each sample, aged 22-40 years old, half male and half female, and the test was conducted on the day of the test and in the next 24 hours when the weather forecast environment basically met the test environment requirements. During the test, the sample was evenly applied to the face, and the Real BubeeRB-916 skin moisture tester was used to regularly detect the skin moisture content of 10 different sites on the face of the subject, and the average was taken, retaining one decimal place. The skin moisture content of the 20 subjects at 0h, 1h, 2h, 3h...12h was averaged, retaining one decimal place.

[0078] Regarding the determination of moisturizing time: when the skin moisture content is lower than 30% or lower than the skin moisture content before applying the sample + 0.2% (+0.2% is the preset correction parameter), moisturizing is considered to fail. If moisturizing fails within the 12h test time, the moisturizing time is the time point when the most recent test is still effective. If moisturizing is still effective during the 12h test, the moisturizing time is calculated by constructing the least squares method using the data of the 10h, 11h, and 12h test points. When calculating the least squares method, if the subject's skin moisture content is higher than 30% before the test, the subject's skin moisture content before the test is used as the critical point of moisturizing time. If the subject's skin moisture content is lower than 30% before the test, the skin moisture content of 30% is used as the critical point of moisturizing time.

[0079] The present invention adopts the following method to detect the antipruritic performance of the composition product: For each sample, 10 subjects with skin itching symptoms were selected as subjects, aged 18-60 years old, regardless of gender. The subjects applied the sample evenly on the itchy skin once in the morning and evening for 5 consecutive days. The time when the itching disappeared or was significantly alleviated after the first application of the sample was taken as the sample onset time. If the itching did not disappear or was not significantly alleviated more than 3 hours after the first application of the sample, it was recorded as invalid. And the number of people who had recurrent itching at the same location during the test was recorded. Example

[0080] A notoginseng composition with facial itching and moisturizing effects comprises, by weight: 100 parts of a matrix component, 0.3 parts of sodium hyaluronate and / or hyaluronic acid, and 2 parts of an additive component. By weight percentage, the matrix component is a mixture of 8 wt.% glycerol and the remainder water.

[0081] In terms of mass, the additive components include: 45 parts of Panax notoginseng extract, 32 parts of ginseng extract, 18 parts of Ophiopogon japonicus extract, and 22 parts of apple extract. The Panax notoginseng extract is 500 mesh powder, the ginseng extract is 500 mesh powder, and the apple extract is 300 mesh powder.

[0082] The apple extract is prepared by the following method: First, wash the fresh apples with skin, cut them into pieces, and immerse them in absolute ethanol with a mass 4 times that of the apples.

[0083] Then, perform cyclic extraction at 40 °C for 60 minutes.

[0084] Finally, filter and separate, take the filtrate part, dry it under negative pressure at 35 °C, and then crush the dried product to a particle size less than or equal to 300 mesh to obtain the apple extract.

[0085] The composition is prepared by the following method: Step 1: Add the additive components in the formulated amounts to the water in the formulated amount, and stir at room temperature for 20 minutes to obtain a mixed solution A. Add the formulated amount of sodium hyaluronate and / or hyaluronic acid to the formulated amount of glycerol, and stir well to obtain a mixed solution B.

[0086] Step 2: Gradually add the mixed solution B to the mixed solution A under stirring.

[0087] Step 3: After the addition is completed, stir until evenly mixed to obtain the Panax notoginseng composition with the efficacy of relieving facial itching and moisturizing.

[0088] The applicant confirms the appropriate addition amounts of Panax notoginseng extract, ginseng extract, Ophiopogon japonicus extract, and apple extract in the additives based on the cost-effectiveness ratio. The cost-effectiveness ratio calculation formula adopted in the present invention is: F = Cn / B Among them, F is the calculated cost-effectiveness ratio. B is the selling price of the additive, and the calculation method is: B = D * M, where D is the number of grams of the additive and M is the unit price per gram of the additive. Cn is the effect score of the additive, including the moisturizing effect score Cs and the itching relief effect score Cy. When examining the moisturizing cost-effectiveness ratio, Cn = Cs; when examining the itching relief cost-effectiveness ratio, Cn = Cy.

[0089] The moisturizing effect score Cs is obtained by the following formula: Cs = 0.2 * H + 0.8 * Ts Among them, Cs is the moisturizing effect score, H is the moisture content score at 4 h, and Ts is the moisturizing effective time score.

[0090] The score table of H is as follows: Score, H Moisture content, % (4h) 1 25 - 35 (excluding 35) 2 35 - 40 (excluding 40) 3 40 - 42 (excluding 42) 4 42 - 44 (excluding 44) 5 44 - 46 (excluding 46) 6 46 - 47 (excluding 47) 7 47 - 48 (excluding 48) 8 48 - 49 (excluding 49) 9 49 - 50 (excluding 50) 10 ≥50 The score of Ts is the number of hours of the moisturizing time. For example, the moisturizing time of 1 hour is recorded as 1 point, the moisturizing time of 10 hours is recorded as 10 points, and the moisturizing time exceeding 24 hours is all recorded as 24 points.

[0091] The itching relief effect score Cy is determined by the following table: Score, Cy Itching relief onset time, min 0 ≥180 1 120-180 2 90-120 3 60-90 4 50-60 5 40-50 6 30-40 7 20-30 8 15-20 9 10-15 10 ＜10 Based on adding only Panax notoginseng extract, or only ginseng extract, or only Ophiopogon japonicus extract, the applicant determined by adjusting the addition amounts of Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract respectively that: 1. When the addition amount of Panax notoginseng in the composition exceeds 100 parts, the cost-effectiveness ratio decreases significantly; when the addition amount of ginseng extract exceeds 60 parts, the cost-effectiveness ratio decreases significantly; when the addition amount of Ophiopogon japonicus extract exceeds 60 parts, the cost-effectiveness ratio decreases significantly.

[0092] 2. The preferred cost-effectiveness addition amount ranges of Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract in the composition are: 40 - 50 parts of Panax notoginseng extract, 30 - 40 parts of ginseng extract, and 15 - 20 parts of Ophiopogon japonicus extract. The optimal cost-effectiveness addition amounts are: 45 parts of Panax notoginseng extract, 32 parts of ginseng extract, and 18 parts of Ophiopogon japonicus extract.

[0093] Based on the optimal cost-effectiveness addition amounts of Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract: 45 parts of Panax notoginseng extract, 32 parts of ginseng extract, and 18 parts of Ophiopogon japonicus extract, the applicant obtained the relationship diagrams of moisturizing time and the addition amount of apple extract as shown in Figure 1 and Figure 2 , where the X-axis is the addition amount and the Y-axis is the moisturizing time. From Figure 1 and Figure 2 , it can be seen that on the basis of the optimal cost-effectiveness addition amounts of Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract, when the addition amount of apple extract is 20 - 25 parts, the moisturizing time shows an abnormal increase, and the maximum value point is 22 parts.

[0094] In addition, the applicant replaced the apple extract with commercially available quercetin and obtained the relationship diagrams of moisturizing time and the addition amount of quercetin as shown in Figure 1 and Figure 3 , where the X-axis is the addition amount and the Y-axis is the moisturizing time. When replacing the apple extract with apple peel extract and adjusting the addition amount of apple peel extract, the relationship diagrams of moisturizing time and the addition amount of apple peel extract as shown in Figure 1 and Figure 4 were obtained, where the X-axis is the addition amount and the Y-axis is the moisturizing time. When replacing the apple extract with onion outer skin extract and adjusting the addition amount of onion outer skin extract, the relationship diagrams of moisturizing time and the addition amount of onion outer skin extract as shown in Figure 1 and Figure 5 were obtained, where the X-axis is the addition amount and the Y-axis is the moisturizing time. When replacing the apple extract with blueberry extract and adjusting the addition amount of blueberry extract, the relationship diagrams of moisturizing time and the addition amount of blueberry extract as shown in Figure 1 and Figure 6The relationship diagram between the moisturizing time and the addition amount of blueberry extract is shown, where the X-axis is the addition amount and the Y-axis is the moisturizing time. Among them, the apple peel extract, onion outer skin extract, and blueberry extract are all obtained by the extraction method of the apple extract described in Example 2.

[0095] From Figure 1 , Figure 2 , Figure 3 It can be seen that when quercetin is added, as the content of quercetin increases, the moisturizing time of the composition is correspondingly extended, indicating that quercetin has a beneficial effect on promoting the extension of the moisturizing time of the composition of the present invention. However, under specific ratio conditions, the effect of adding apple extract will show an unexpected surge, while this phenomenon does not occur when quercetin is directly added. This shows that the substances that play a synergistic role in the apple extract are not only quercetin but also other components, so that when adding apple extract, the effect of adding 34 parts of quercetin can be achieved with a smaller addition amount (20 - 25 parts), or the effect of adding 36 parts of apple extract can be achieved.

[0096] From Figure 1 , Figure 2 , Figure 4 It can be seen that the biomass substances that play a synergistic role in the apple extract are not concentrated in the apple peel, but should be concentrated in the apple pulp and can be extracted by ethanol. Therefore, when adding apple peel extract, the moisturizing time increases with the increase of the addition amount, and there is no surge at a specific addition amount.

[0097] From Figure 1 , Figure 2 , Figure 5 , Figure 6 It can be seen that when adding onion outer skin extract or blueberry extract, the moisturizing time increases with the increase of the addition amount, and there is no surge at a specific addition amount, that is, this biomass substance that produces a synergistic effect with the composition of the present invention is not widely present.

[0098] Comparative Example 1.1 The remaining ratios and steps are the same as those in Example 1, except that: the apple extract is prepared by the following method: First, wash the fresh apples with skin and cut them into pieces, then immerse them in 4 times the mass of deionized water.

[0099] Then, perform cyclic extraction at 40 °C for 60 minutes.

[0100] Finally, filter and separate, take the filtrate part, dry it under negative pressure at 35 °C, and then crush the dried product to a particle size less than or equal to 300 mesh to obtain the apple extract.

[0101] Comparative Example 1.2 The remaining ratios and steps are the same as those in Example 1, except that: commercially available quercetin powder (300 mesh) of equal mass is used instead of the apple extract.

[0102] Comparative Example 1.3 The remaining ratios and steps are the same as those in Example 1, except that: only the apple extract is added, and the notoginseng extract, ginseng extract, and ophiopogon japonicus extract are not added.

[0103] Comparative Example 1.4 The remaining ratios and steps are the same as those in Example 1, except that: the notoginseng extract, ginseng extract, and ophiopogon japonicus extract are added, and the apple extract is not added.

[0104] Comparative Example 1.5 The remaining ratios and steps are the same as those in Example 1, except that: only the notoginseng extract is added, and the apple extract, ginseng extract, and ophiopogon japonicus extract are not added.

[0105] Comparative Example 1.6 The remaining ratios and steps are the same as those in Example 1, except that: only the ginseng extract and ophiopogon japonicus extract are added, and the apple extract and notoginseng extract are not added.

[0106] Comparative Example 1.7 The remaining ratios and steps are the same as those in Example 1, except that: the apple extract and notoginseng extract are added, and the ginseng extract and ophiopogon japonicus extract are not added.

[0107] Comparative Example 1.8 The remaining ratios and steps are the same as those in Example 1, except that: the apple extract, ginseng extract, and ophiopogon japonicus extract are added, and the notoginseng extract is not added.

[0108] Comparative Example 1.9 The remaining ratios and steps are the same as those in Example 1, except that: quercetin and notoginseng extract are added, and the ginseng extract and ophiopogon japonicus extract are not added.

[0109] Comparative Example 1.10 The remaining ratios and steps are the same as those in Example 1, except that: quercetin, ginseng extract, and ophiopogon japonicus extract are added, and the notoginseng extract is not added.

[0110] Comparative Example 1.11 The remaining ratios and steps are the same as those in Example 1, except that: the extract is peeled apples.

[0111] Comparative Example 1.12 The remaining ratios and steps are the same as those in Example 1, except that: the notoginseng extract is replaced with an equal amount of safflower powder.

[0112] Comparative Example 1.13 The remaining ratios and steps are the same as those in Example 1, except that: 32 parts of ginseng extract and 18 parts of ophiopogon japonicus extract are replaced with: 50 parts of ginseng extract.

[0113] Control Example 1.14 The remaining ratios and steps are the same as those in Example 1, except that: 32 parts of ginseng extract and 18 parts of ophiopogon japonicus extract are replaced with: 50 parts of ophiopogon japonicus extract.

[0114] Reference Group 1 The remaining ratios and steps are the same as those in Example 1, except that: the additive components of the present invention are not added.

[0115] The samples obtained from Example 1, Control Examples 1.1 to 1.14 and Reference Group 1 were tested for moisturizing effect together, and the results are shown in Table 1.

[0116] Table 1. Moisturizing effect test table of the samples obtained from Example 1, Control Examples 1.1 to 1.13 and Reference Group 1

[0117] As can be seen from the above table: 1. From the comparison between Example 1, Control Example 1.1 and Control Example 1.4, it can be seen that the water extract of apple did not significantly change the moisturizing time efficacy of the composition of the present invention, while the alcohol extract of apple can significantly change the moisturizing time of the composition of the present invention. 2. From the comparison between Example 1, Control Examples 1.2, 1.4, 1.11, it can be seen that the alcohol extract of peeled apple has a certain improvement effect on the moisturizing time of the composition of the present invention, but this improvement effect is significantly weaker than the effect of adding quercetin, and the improvement effect of adding only quercetin alone is weaker than that of adding the apple extract of the present invention (containing both quercetin and apple biomass). It can be seen that the improvement effect of the apple extract of the present invention on the moisturizing time of the composition of the present invention not only comes from the moisturizing improvement effect of quercetin, but also comes from the synergistic effect of apple biomass.

[0118] 3. It can be seen from the comparison between Example 1 and Comparative Examples 1.3, 1.4, and Control Group 1 that adding only the apple extract of the present invention or only adding Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract can all improve the moisturizing time of the matrix components of the present invention to a certain extent, but the effect is significantly weaker than that when adding the additives of the present invention simultaneously. Without considering the factor that the longer the moisturizing time, the greater the difficulty of moisturization, only comparing the absolute increase in moisturizing time shows that adding only the apple extract of the present invention can increase the moisturizing time by 2 hours, and adding only Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract can increase the moisturizing time by 3 hours. When adding apple extract, Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract simultaneously, the moisturizing time increased by 10 hours, exceeding the theoretical increase time of 5 hours. Therefore, a synergistic effect occurred between the apple extract of the present invention and Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract, resulting in a significant increase in the moisturizing time of the composition beyond the theory.

[0119] 4. It can be seen from Example 1 and Comparative Examples 1.4 to 1.14 that adding only ginseng extract, Ophiopogon japonicus extract, and apple extract slightly improves the moisturizing time of the composition compared to adding only ginseng extract and Ophiopogon japonicus extract, but it is significantly weaker than the composition adding quercetin, ginseng extract, and Ophiopogon japonicus extract. Adding only Panax notoginseng extract and apple extract slightly improves the moisturizing time of the composition compared to adding only Panax notoginseng extract, but it is significantly weaker than the composition adding quercetin and Panax notoginseng. Only when adding Panax notoginseng extract, ginseng extract, Ophiopogon japonicus extract, and apple extract simultaneously will there be a relatively obvious increase in the moisturizing time. Combining Comparative Example 1.12 (replacing Panax notoginseng extract with safflower powder with similar medicinal properties), Comparative Example 1.13 (only ginseng extract), and Comparative Example 1.14 (only Ophiopogon japonicus extract), it can be seen that the addition of apple extract mainly enhances the moisturizing time of the Panax notoginseng composition of the present invention through synergistic action with Panax notoginseng extract, ginseng extract, and Ophiopogon japonicus extract.

[0120] Example 2 Based on the Panax notoginseng composition with facial itching-relieving and moisturizing effects in Example 1, the additive components further include cinnamon extract or schisandra chinensis extract or a mixture of cinnamon extract and schisandra chinensis extract, and the addition amount of cinnamon extract or schisandra chinensis extract or a mixture of cinnamon extract and schisandra chinensis extract is 1 - 20 parts.

[0121] In order to further enhance the itching-relieving effect of the composition of the present invention, the applicant added schisandra chinensis extract, cinnamon extract, and an equimass ratio mixture of schisandra chinensis extract and cinnamon extract to the composition in Example 1 respectively, and tested their itching-relieving effects. Taking the addition amount as the X-axis and the average onset time of the subjects as the Y-axis, we obtained Figure 7 , where there are no invalid cases.

[0122] From Figure 7 It can be seen that as the addition amount of cinnamon extract or schisandra chinensis extract or the mixture of cinnamon extract and schisandra chinensis extract increases, the antipruritic effect of the composition of the present invention can be improved. However, at the same addition amount, the effect of the equal mass ratio mixture of schisandra chinensis extract and cinnamon extract is significantly better than that of adding schisandra chinensis extract or cinnamon extract alone. It can be seen that the combination of schisandra chinensis extract and cinnamon extract has a synergistic effect on the composition of the present invention, significantly improving the antipruritic effect.

[0123] In addition, when the schisandra chinensis extract, cinnamon extract and the equal mass ratio mixture of schisandra chinensis extract and cinnamon extract are not added, there are 13 person-times of recurrent itching during the antipruritic performance test of the composition of the present invention. When the schisandra chinensis extract is added alone, the number of person-times of recurrent itching drops below 8 person-times. When the cinnamon extract is added alone, the number of person-times of recurrent itching drops below 9 person-times. When the equal mass ratio mixture of schisandra chinensis extract and cinnamon extract is added, the number of person-times of recurrent itching drops below 5 person-times. At the same addition amount, the number of person-times of recurrent itching of the equal mass ratio mixture of schisandra chinensis extract and cinnamon extract is better than that of adding schisandra chinensis extract or cinnamon extract alone.

[0124] Comparative Example 2.1 Based on the panax notoginseng composition with facial antipruritic and moisturizing effects in Example 1, the additive components further include artemisia argyi extract and the equal mass ratio mixture with schisandra chinensis extract.

[0125] Comparative Example 2.2 Based on the panax notoginseng composition with facial antipruritic and moisturizing effects in Example 1, the additive components further include artemisia argyi extract and the equal mass ratio mixture with cinnamon extract.

[0126] After the applicant replaces the schisandra chinensis extract or cinnamon extract in the equal mass ratio mixture of schisandra chinensis extract and cinnamon extract in Example 2 with artemisia argyi extract, the antipruritic effect is tested as shown in Figure 8. Figure 9 as shown.

[0127] From Figure 8 It can be seen that after replacing the cinnamon extract with an equal amount of artemisia argyi extract, there is a relatively obvious deterioration in the antipruritic effect of the present invention, which is not only significantly weaker than the mixture of schisandra chinensis extract and cinnamon extract, but even weaker than the effect of using schisandra chinensis extract alone.

[0128] From Figure 9 It can be seen that after replacing the schisandra chinensis extract with an equal amount of artemisia argyi extract, there is a relatively obvious deterioration in the antipruritic effect of the present invention, which is not only significantly weaker than the mixture of schisandra chinensis extract and cinnamon extract, but even weaker than the effect of using cinnamon extract alone.

[0129] It can be seen that when the Schisandra chinensis extract and the Cinnamomum cassia extract are added simultaneously to the composition of the present invention, a synergistic effect of relieving itching can be produced, and the itching-relieving effect is significantly improved.

[0130] Example 3 Based on the Panax notoginseng composition with facial itching-relieving and moisturizing effects in Example 1, the additive components further include 6 parts of Cinnamomum cassia extract with a mesh size of 300 and 4 parts of Schisandra chinensis extract with a mesh size of 300. At this time, the addition amounts of the Cinnamomum cassia extract and the Schisandra chinensis extract are 45.45% of the addition amount of the apple extract.

[0131] In order to verify the influence of the Cinnamomum cassia extract and the Schisandra chinensis extract on the moisturizing effect of the composition of the present invention, the applicant added the Schisandra chinensis extract, the Cinnamomum cassia extract and an equimass ratio mixture of the Schisandra chinensis extract and the Cinnamomum cassia extract to the composition in Example 1 respectively, and conducted a moisturizing performance test. With the addition amount as the X-axis and the moisturizing time as the Y-axis, the following was obtained Figure 10 .

[0132] From Figure 10 It can be seen that when only the Schisandra chinensis extract or the Cinnamomum cassia extract is added, basically as the addition amount increases, the moisturizing time gradually decreases. The possible reason is that when the Schisandra chinensis extract or the Cinnamomum cassia extract is added alone, it affects the synergistic effect of the apple extract of the present invention on the moisturizing effect of the composition of the present invention, resulting in different degrees of decrease in the moisturizing time. And as the addition amount of the Schisandra chinensis extract or the Cinnamomum cassia extract increases, this influencing effect intensifies, thus causing the moisturizing time to gradually decrease.

[0133] However, when the Schisandra chinensis extract and the Cinnamomum cassia extract are added in the same ratio, when the addition amount is 9 - 12 parts, compared with adding the Schisandra chinensis extract or the Cinnamomum cassia extract alone, there is no further weakening of the moisturizing effect. It may be that when the Schisandra chinensis extract and the Cinnamomum cassia extract are added simultaneously, at this addition amount, the influence on the synergistic effect of the apple extract is weakened, or a certain synergistic effect appears, counteracting the coordinated weakening effect on the apple extract.

[0134] Therefore, through further research, the applicant found that when there are 6 parts of Cinnamomum cassia extract, 4 parts of Schisandra chinensis extract, and the addition amount of apple extract is 22 parts, the moisturizing time of the composition is further increased to the original 13 hours, and the itching-relieving effect still remains at the effect when the addition amount of the additive is 10 parts.

[0135] Example 4 Based on the Panax notoginseng composition with facial itching-relieving and moisturizing effects in Example 3, after adding the additive components in the formula amount to the water in the formula amount in step 1, it was stirred and processed for 3 minutes in a 2450 MHz microwave field at an environment of 25 - 30 °C to obtain a mixed solution A.

[0136] After the moisturizing and antipruritic performance tests, the moisturizing time is still 13 hours at this time, but the antipruritic onset time is reduced from 15 minutes at the corresponding addition amount in Example 3 to 11 minutes, that is, the antipruritic onset time is significantly improved. This is because after microwave treatment, the effective substances of each component additive are fully released into the aqueous solvent, thereby significantly improving the onset time of the composition of the present invention.

[0137] Inspired by the ideal embodiments of the present invention described above, through the above description, relevant staff can make various changes and modifications completely within the scope not deviating from the technical idea of the present invention. The technical scope of the present invention is not limited to the content in the specification, and its technical scope must be determined according to the scope of the claims.

Claims

1. A Panax notoginseng composition with the efficacy of relieving facial itching and moisturizing, characterized in that, By mass parts, it includes: 100 parts of matrix component, 0.1 - 0.5 part of sodium hyaluronate and / or hyaluronic acid, and 1 - 3 parts of additive component; by mass percentage, the matrix component is a mixture of 5 - 10 wt.% of glycerol and the balance of water. By mass parts, the additive component includes: 10 - 100 parts of Panax notoginseng extract, 10 - 60 parts of ginseng extract, 10 - 60 parts of Ophiopogon japonicus extract, and 10 - 50 parts of apple extract.

2. The notoginseng composition with facial itching-relieving and moisturizing effects according to claim 1, wherein By mass parts, the additive component includes: 40 - 50 parts of Panax notoginseng extract, 30 - 40 parts of ginseng extract, 15 - 20 parts of Ophiopogon japonicus extract, and 20 - 25 parts of apple extract.

3. The Panax notoginseng composition with the efficacy of relieving facial itching and moisturizing according to any one of claims 1 or 2, characterized in that, The apple extract is prepared by the following method: First, wash the fresh apples with skin, cut them into pieces, and immerse them in absolute ethanol with a mass 4 times that of the apples. Then, perform cyclic extraction at a temperature of 35 - 45 °C for 40 - 80 minutes. Finally, filter and separate, take the filtrate part, perform negative pressure drying at 30 - 40 °C, and then crush the dried product to a particle size less than or equal to 200 mesh to obtain the apple extract.

4. The notoginseng composition with the efficacy of relieving facial itching and moisturizing according to any one of claims 1 or 2, characterized in that, The apple extract is prepared by the following method: First, wash the fresh apples with skin, cut them into pieces, and immerse them in absolute ethanol with a mass 4 times that of the apples. Then, perform cyclic extraction at a temperature of 35 - 45 °C for 40 - 80 minutes. Finally, filter and separate, take the filtrate part, perform negative pressure drying at 30 - 40 °C, and then crush the dried product to a particle size less than or equal to 200 mesh to obtain the apple extract.

5. The Panax notoginseng composition with facial itching relief and moisturizing effects according to claim 1, characterized in that, By mass parts, the additive component further includes: 1 - 20 parts of composite component; the composite component at least includes at least one of cinnamon extract and Schisandra chinensis extract.

6. The Panax notoginseng composition with facial itching relief and moisturizing effects according to claim 4, characterized in that By mass parts, the composite component includes: 6 parts of cinnamon extract and 4 parts of Schisandra chinensis extract; the addition amount of the composite component is 40 - 55% of the mass of the apple extract.

7. The notoginseng composition with facial itching-relieving and moisturizing effects according to any one of claims 5 or 6, characterized in that, The particle size of the cinnamon extract and the Schisandra chinensis extract is less than or equal to 300 mesh.

8. The Panax notoginseng composition with the efficacy of relieving facial itching and moisturizing according to claim 1, wherein The composition is prepared by the following method: Step 1: Add the formulated amount of additive component to the formulated amount of water, stir at room temperature for 20 minutes to obtain mixture A; add the formulated amount of sodium hyaluronate and / or hyaluronic acid to the formulated amount of glycerol, stir well to obtain mixture B. Step 2: Gradually add mixture B to mixture A under stirring. Step 3: After the addition is completed, stir until evenly mixed to obtain the Panax notoginseng composition with the efficacy of relieving itching and moisturizing the face.

9. The notoginseng composition with facial itching-relieving and moisturizing effects according to claim 8, characterized in that, In Step 1, after adding the formulated amount of additive component to the formulated amount of water, perform stirring treatment in a 2450 MHz microwave field at 25 - 30 °C for 3 minutes to obtain mixture A.

10. The notoginseng composition with the efficacy of relieving facial itching and moisturizing according to claim 1, wherein, It also includes 0.1 - 0.3 part of phenoxyethanol and 0.1 - 1.0 part of aroma component.

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