Defecating composition and application thereof

Abstract

The invention provides a bowel-relaxing composition and application thereof, the bowel-relaxing composition comprises the following components in parts by weight: 5-10 parts of enzyme powder, 68.5-84.5 parts of dietary fiber and 9-15 parts of a traditional Chinese medicine mixture, and the traditional Chinese medicine mixture comprises the following components in parts by weight: 3-5 parts of an astragalus extract, 3-5 parts of a codonopsis pilosula extract and 3-5 parts of a cistanche extract. Experiments show that the bowel-relaxing composition not only can quickly relieve constipation, but also can effectively improve the relative abundance of beneficial bacteria and repair damaged intestinal functions, and adverse reactions are effectively improved, so that the dependency risk of traditional laxative is avoided.

Description

Technical Field

[0001] The present invention relates to the field of biomedical technologies, and particularly relates to a laxative composition and its application. Background Art

[0002] Currently, commercially available laxative products mainly focus on two directions: drug intervention and functional ingredient regulation, but both have significant limitations. Drug-based laxatives act directly on the intestine by relying on stimulatory ingredients or creating a hypertonic environment. For example, stimulant laxatives (such as bisacodyl, senna leaf, rhubarb, etc.) accelerate peristalsis by stimulating intestinal nerves, but long-term use can lead to intestinal melanosis and irreversible nerve damage; osmotic laxatives (such as polyethylene glycol, lactulose, etc.) create a hypertonic environment in the intestine, absorb water, and increase the volume of feces, but are prone to causing abdominal distension, nausea, etc., and overuse can also lead to imbalance of water and electrolytes in the body, triggering adverse reactions such as headache and dehydration; bulk-forming laxatives (such as wheat cellulose, psyllium, etc.) stimulate intestinal peristalsis by increasing the water content and volume of feces, but have a slow onset, usually require a large amount of water intake, and have poor effects on patients with slow intestinal motility, and may also cause discomfort such as abdominal distension and flatulence. Rare serious adverse reactions include intestinal obstruction. Lubricant laxatives (such as glycerin suppository, docusate sodium, etc.) lubricate the intestinal wall and soften feces, but long-term use poses risks such as poor absorption of fat-soluble vitamins and perianal pruritus. Although these drugs have significant effects in the short term, they generally have a risk of dependence and side effects, and it is difficult to meet the safety requirements for long-term use.

[0003] In the field of natural ingredients, prebiotics (such as dietary fibers like fructooligosaccharide, polydextrose, resistant dextrin, etc.) soften feces by absorbing water and swelling, directly stimulating the intestinal wall, and on the other hand, regulate intestinal function by improving the abundance of beneficial bacteria, but have a slow onset and require a relatively large daily intake to take effect, while high doses are prone to causing side effects such as abdominal distension and diarrhea. Insoluble dietary fibers (such as psyllium husk) promote defecation by physically absorbing water and swelling, but cannot regulate the balance of the flora, and the high fiber content results in poor taste, inconvenient administration, and is prone to causing abdominal distension. Enzyme products can assist in decomposing food residues, but are prone to tolerance and lack the function of directly promoting intestinal motility, so other ingredients that promote intestinal peristalsis need to be compounded. Probiotics (such as Bifidobacterium, Lactobacillus, etc.) regulate the balance of the intestinal flora by supplementing probiotics, but the colonization of probiotics is difficult, the onset is slow, and it is easily affected by living habits, drugs, etc.

[0004] To solve the problems existing in single natural components and achieve rapid efficacy and safety, some laxative compositions have also been disclosed in the prior art. For example, Patent CN119177198B uses five probiotics, namely Lactobacillus reuteri HBM11-69, Pediococcus pentosaceus MPL5, Lactobacillus plantarum La-10, Lactobacillus rhamnosus HBM11-35, and Lactobacillus casei C7-2, which cooperate with each other and synergistically enhance the effect. By increasing the small intestine propulsion rate and reducing the number of diarrhea episodes, etc., it can effectively restore the balance of the intestinal flora structure. Patent CN116019226A uses prebiotics such as isomaltooligosaccharide in combination with marine prebiotic chitosan oligosaccharide and comprehensive fruit and vegetable fermentation powder, which can jointly promote intestinal health and improve immunity. Patent CN114794485A uses a nutritional product made of probiotics, prebiotics, fruit and vegetable plant enzyme powder, glutamine, betaine hydrochloride, and β-carotene, which has the effects of regulating the intestines and improving immunity. However, these studies mainly focus on simple compounding. For example, the compounding of laxative oligosaccharides and probiotics is limited by the low survival rate of live bacteria, and the mixing of dietary fiber and irritant components, although shortening the onset time, cannot avoid side effects such as abdominal pain and diarrhea. These technical bottlenecks expose the core contradictions in the current laxative field: the opposition between rapid efficacy and safety, the imbalance between dosage and side effects, and the difficulty of a single mechanism of action to cover complex etiologies. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a laxative composition and its application.

[0006] The first aspect of the present invention provides a laxative composition, comprising the following components by weight: 5 parts to 10 parts of enzyme powder, 68.5 parts to 84.5 parts of dietary fiber, and 9 parts to 15 parts of traditional Chinese medicine mixture, wherein the traditional Chinese medicine mixture comprises the following components by weight: 3 parts to 5 parts of astragalus extract, 3 parts to 5 parts of codonopsis pilosula extract, and 3 parts to 5 parts of cistanche deserticola extract.

[0007] Further, the dietary fiber comprises oligosaccharides and polysaccharides.

[0008] Furthermore, the oligosaccharides are the following components by weight: 10 parts to 12 parts of xylooligosaccharide, 20 parts to 25 parts of fructooligosaccharide, and 8 parts to 12 parts of isomaltooligosaccharide.

[0009] Furthermore, the polysaccharides are the following components by weight: 1 part to 1.5 parts of aloe polysaccharide, 8 parts to 10 parts of galactomannan, and 21.5 parts to 24 parts of resistant dextrin.

[0010] Furthermore, the preparation method of the traditional Chinese medicine mixture comprises: Putting codonopsis pilosula, astragalus, and cistanche deserticola into an extraction tank loaded with an extraction solvent respectively, and performing decoction treatment and filtration treatment to obtain codonopsis pilosula filtrate, astragalus filtrate, and cistanche deserticola filtrate; The dangshen filtrate, the astragalus membranaceus filtrate and the cistanche deserticola filtrate are respectively concentrated and dried to obtain dangshen extract, astragalus membranaceus extract and cistanche deserticola extract; The dangshen extract, the astragalus membranaceus extract and the cistanche deserticola extract are mixed to form a traditional Chinese medicine mixture.

[0011] In a second aspect, the present invention provides an application of the laxative composition as described in the first aspect above in the preparation of a product for relieving constipation and repairing intestinal function.

[0012] Furthermore, the product is a food or a medicine.

[0013] Compared with the prior art, the beneficial effects of the present invention are as follows: First, rapid promotion of defecation is achieved through the synergistic effect of enzymes and water-soluble polysaccharide dietary fiber. Enzymes can efficiently decompose food residues, reducing the volume of food residues and making it easier to pass through the narrow intestinal space; while water-soluble polysaccharide dietary fiber can absorb water, making the feces softer, further reducing the difficulty of passing through the intestine, and it also has a laxative effect to avoid intestinal dryness. Second, the water-soluble dietary fiber with the compound of oligosaccharides and polysaccharides has good gastrointestinal digestion resistance characteristics, can improve the relative abundance of probiotics, and promote the restoration of the intestinal microecological balance. Finally, by adding medicinal and edible homologous ingredients such as dangshen, astragalus membranaceus, and cistanche deserticola, it can invigorate qi and strengthen the spleen, repair the intestinal barrier, promote intestinal function health, ensure long-term effects, and prevent recurrence. The laxative composition in this application takes effect within 2 hours to 12 hours, achieving a lasting laxative effect by rapidly relieving constipation, improving the relative abundance of beneficial bacteria, and repairing damaged intestines, and can also avoid the risk of dependence on traditional laxatives. Description of the Drawings

[0014] Figure 1 It is a diagram of the enzyme activity detection result of the laxative composition in Example 1 of the present invention; The following specific embodiments will further illustrate the present invention in conjunction with the above-mentioned drawings. Specific Embodiments

[0015] To facilitate the understanding of the present invention, the present invention will be described more comprehensively below with reference to the relevant drawings. Several embodiments of the present invention are given in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0016] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly on the other element or there can also be an intermediate element. When an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used in this article are only for the purpose of illustration.

[0017] Unless otherwise defined, all technical and scientific terms used in this article have the same meaning as commonly understood by those skilled in the technical field to which this invention belongs. The terms used in the specification of this invention are only for the purpose of describing specific embodiments and are not intended to limit this invention. The term "and / or" used in this article includes any and all combinations of one or more of the related listed items.

[0018] In a first aspect, Embodiment 1 of the present invention provides a laxative composition, comprising the following components by weight: 5 parts of enzyme powder, 68.5 parts of dietary fiber, and 9 parts of traditional Chinese medicine mixture. In this embodiment, the enzyme powder is purchased from Qingdao Huibaicui Biotechnology Co., Ltd., and the traditional Chinese medicine mixture includes astragalus extract, codonopsis extract, and cistanche extract. Preferably, the dietary fiber is water-soluble dietary fiber.

[0019] Among them, the preparation method of the traditional Chinese medicine mixture includes: putting codonopsis, astragalus, and cistanche into an extraction tank loaded with an extraction solvent, and performing decoction treatment and filtration treatment to obtain codonopsis filtrate, astragalus filtrate, and cistanche filtrate; preferably, the number of times of the decoction treatment is greater than or equal to two, and the number of times of the decoction treatment is the same as that of the filtration treatment. The temperature of the decoction treatment is 90°C to 100°C, and the time of the decoction treatment is 1h to 3h. In this embodiment, the number of times of the decoction treatment is two, the number of times of the filtration treatment is two, the temperature of the decoction treatment is 100°C, the time of the first decoction treatment is 2h, the time of the second decoction treatment is 1.5h, and the extraction solvent is water. Specifically, taking codonopsis as an example, after putting codonopsis into an extraction tank loaded with water for one decoction, the first codonopsis decoction liquid is obtained. After filtering the first codonopsis decoction liquid once, the first filtrate and the first filter residue are obtained. After decocting the first filter residue for the second time, the second codonopsis decoction liquid is obtained. After filtering the second codonopsis decoction liquid twice, the second filtrate and the second filter residue are obtained. The first filtrate and the second filtrate are combined into the codonopsis filtrate. The obtaining methods of the astragalus filtrate and the cistanche filtrate are the same and will not be elaborated here.

[0020] The Codonopsis pilosula filtrate, the Astragalus membranaceus filtrate, and the Cistanche deserticola filtrate are respectively concentrated and dried to obtain Codonopsis pilosula extract, Astragalus membranaceus extract, and Cistanche deserticola extract; preferably, the temperature of the concentration treatment is 50°C to 70°C. In this embodiment, the temperature of the concentration treatment is 60°C. Tonify the middle-Jiao and replenish qi with the Astragalus membranaceus extract, enhance the transportation and transformation functions of the spleen and stomach, and improve insufficient intestinal motility. Invigorate qi and strengthen the spleen with the Codonopsis pilosula extract, synergistically enhance the qi-tonifying effect with the Astragalus membranaceus extract, and promote intestinal peristalsis ability. Tonify the kidney yang, benefit essence and blood, moisten the intestines and relieve constipation with the Cistanche deserticola extract, provide a mild laxative effect for intestinal dryness or weak peristalsis. The three form a synergistic mechanism to solve the problem of insufficient intestinal propulsion force and can directly soften the feces. Moreover, the three are all mild medicinal and edible herbs. The Astragalus membranaceus extract and the Codonopsis pilosula extract are tonifying herbs with high safety. The Cistanche deserticola extract belongs to the moistening laxative herbs without the harm of severe purgation to healthy qi.

[0021] Mix the Codonopsis pilosula extract, the Astragalus membranaceus extract, and the Cistanche deserticola extract to form a traditional Chinese medicine mixture. In this embodiment, the Codonopsis pilosula extract, the Astragalus membranaceus extract, and the Cistanche deserticola extract are mixed into the traditional Chinese medicine mixture according to the following weight parts: 3 parts of the Astragalus membranaceus extract, 3 parts of the Codonopsis pilosula extract, and 3 parts of the Cistanche deserticola extract.

[0022] Preferably, the dietary fiber includes oligosaccharides and polysaccharides. The oligosaccharides are xylooligosaccharide, fructooligosaccharide, and isomaltooligosaccharide, and the polysaccharides are aloe polysaccharide, galactomannan, and resistant dextrin. Further, in this embodiment, the oligosaccharides are the following components by weight: 10 parts of xylooligosaccharide, 20 parts of fructooligosaccharide, and 8 parts of isomaltooligosaccharide, and the polysaccharides are the following components by weight: 1 part of aloe polysaccharide, 8 parts of galactomannan, and 21.5 parts of resistant dextrin. It can be understood that after mixing the xylooligosaccharide, the fructooligosaccharide, the isomaltooligosaccharide, the aloe polysaccharide, the galactomannan, and the resistant dextrin into the dietary fiber according to the above weight parts, mix the enzyme powder, the dietary fiber, and the traditional Chinese medicine mixture to form the laxative composition.

[0023] Please refer to Figure 1, after obtaining the laxative composition, its enzyme activity was detected. A sodium phosphate buffer solution with a concentration of 0.1 M and a pH of 7.4 containing 300 μM of NBT (nitroblue tetrazolium) and 0.5 units / mL of XOD (xanthine oxidase) was prepared. At 25 °C, 100 μL of the sample to be tested was added to 100 μL of NBT and 40 μL of XOD, and the reaction was carried out for 6 minutes. The rate of inhibition of superoxide anion generation per minute by the sample was measured at a wavelength of 560 nm. A 0.1 M sodium phosphate buffer solution with a pH of 7.4 was used to replace the sample as a blank control. The lower the absorbance value, the higher the SOD enzyme activity. The results showed that at 60 °C, the SOD enzyme activity of the laxative composition was 90.5%. The enzymes in the enzyme powder are easily inactivated under storage and processing conditions. Compared with the control group, in this application, the enzyme activity can still be maintained at 90.5% at 60 °C, which indicates that through the combination method of this application, the laxative composition can have good processing and thermal stability, is not easily inactivated during the processing process, and thus maintains good efficacy.

[0024] Example 2 of the present invention provides a laxative composition, which is different from the laxative composition described in Example 1 in that: The laxative composition comprises the following components in parts by weight: 10 parts of enzyme powder, 84.5 parts of dietary fiber, and 15 parts of traditional Chinese medicine mixture. In this embodiment, the traditional Chinese medicine mixture comprises the following components in parts by weight: 5 parts of astragalus extract, 5 parts of codonopsis pilosula extract, and 5 parts of cistanche deserticola extract. The oligosaccharides are the following components in parts by weight: 12 parts of xylooligosaccharide, 25 parts of fructooligosaccharide, and 12 parts of isomaltooligosaccharide. The polysaccharides are the following components in parts by weight: 1.5 parts of aloe polysaccharide, 10 parts of galactomannan, and 24 parts of resistant dextrin.

[0025] Example 3 of the present invention provides a laxative composition, which is different from the laxative composition described in Example 1 in that: The laxative composition comprises the following components in parts by weight: 8 parts of enzyme powder, 78 parts of dietary fiber, and 12 parts of traditional Chinese medicine mixture. In this embodiment, the traditional Chinese medicine mixture comprises the following components in parts by weight: 4 parts of astragalus extract, 4 parts of codonopsis pilosula extract, and 4 parts of cistanche deserticola extract. The oligosaccharides are the following components in parts by weight: 12 parts of xylooligosaccharide, 25 parts of fructooligosaccharide, and 8 parts of isomaltooligosaccharide. The polysaccharides are the following components in parts by weight: 1.5 parts of aloe polysaccharide, 8 parts of galactomannan, and 23.5 parts of resistant dextrin.

[0026] Comparative Example 1 of the present invention provides a laxative composition, which is different from the laxative composition described in Example 1 in that: The laxative composition comprises the following components by weight: 2 parts of enzyme powder, 48 parts of dietary fiber, and 6 parts of traditional Chinese medicine mixture. In this comparative example, the traditional Chinese medicine mixture comprises the following components by weight: 2 parts of astragalus extract, 2 parts of codonopsis pilosula extract, and 2 parts of cistanche deserticola extract; the oligosaccharide comprises the following components by weight: 5 parts of xylooligosaccharide, 18 parts of fructooligosaccharide, and 3 parts of isomaltooligosaccharide; the polysaccharide comprises the following components by weight: 0.5 part of aloe polysaccharide, 3 parts of galactomannan, and 18.5 parts of resistant dextrin.

[0027] Comparative Example 2 of the present invention provides a laxative composition, which is different from the laxative composition described in Example 1 in that: The laxative composition comprises the following components by weight: 68.5 parts of dietary fiber and 9 parts of traditional Chinese medicine mixture. That is, in this comparative example, the enzyme powder is not added.

[0028] Comparative Example 3 of the present invention provides a laxative composition, which is different from the laxative composition described in Example 1 in that: The laxative composition comprises the following components by weight: 5 parts of enzyme powder and 9 parts of traditional Chinese medicine mixture. That is, in this comparative example, the dietary fiber is not added.

[0029] Comparative Example 4 of the present invention provides a laxative composition, which is different from the laxative composition described in Example 1 in that: The laxative composition comprises the following components by weight: 5 parts of enzyme powder and 68.5 parts of dietary fiber. That is, in this comparative example, the traditional Chinese medicine composition is not added.

[0030] Comparative Example 5 of the present invention provides a laxative composition, which is different from the laxative composition described in Example 1 in that: The laxative composition comprises the following components by weight: 5 parts of enzyme powder. That is, in this comparative example, the dietary fiber and the traditional Chinese medicine composition are not added.

[0031] Comparative Example 6 of the present invention provides a laxative composition, which is different from the laxative composition described in Example 1 in that: The laxative composition comprises the following components by weight: 68.5 parts of dietary fiber. That is, in this comparative example, the enzyme powder and the traditional Chinese medicine composition are not added.

[0032] Comparative Example 7 of the present invention provides a laxative composition, which is different from the laxative composition described in Example 1 in that: The laxative composition comprises the following components by weight: 9 parts of traditional Chinese medicine mixture. That is, in this comparative example, the enzyme powder and the dietary fiber are not added.

[0033] Comparative Example 8 of the present invention provides a laxative composition, which is different from the laxative composition described in Example 1 in that: The laxative composition in this comparative example is a commercially available laxative product in a certain city, which specifically includes: water, sorbitol, lactitol, inulin, fructooligosaccharide, resistant dextrin, concentrated prune juice, concentrated lemon juice, xylooligosaccharide powder, probiotic fermentation powder, Opuntia ficus-indica, yeast β-glucan, comprehensive fruit and vegetable fermentation broth (banana, grape, persimmon, lemon, grapefruit, litchi, apple, pineapple, Chinese cabbage, balsam pear, kale, eggplant, crown daisy, sweet potato, beet, radish, broccoli, tomato, wax gourd, burdock root, houttuynia cordata, pumpkin seed, semen raphani, polygonatum sibiricum, fructooligosaccharide, yeast, lactobacillus plantarum, acetic acid bacteria), semen cassiae powder, semen cannabis powder, wolfberry powder, kudzu root powder, licorice powder, instant tangerine peel powder, cinnamon powder, turmeric, DL-malic acid, citric acid, food flavor.

[0034] Verify the laxative effect and side effects of the laxative compositions described in Examples 1-3 and Comparative Examples 1-8 of the present invention: Selection criteria for testers: Aged between 18 and 65 years old, gender is not limited; meeting the diagnosis of chronic functional constipation in the Rome IV standard: defecation frequency ≤ 2 times / week, ≥ 25% of defecations require straining, ≥ 25% of defecations are hard stools (Bristol stool type 1-2), and the symptoms persist for ≥ 6 months; being able to cooperate to maintain the regularity of life during the test; being able to read and understand all the contents of the informed consent form and voluntarily sign the informed consent form; agreeing not to use any foods, drugs, and health products that have an impact on the results during the test; the number of people is 220, evenly divided into 11 groups, corresponding to the examples and comparative examples respectively.

[0035] Exclusion criteria for testers: Secondary constipation (such as intestinal obstruction, diabetic neuropathy, hypothyroidism); having used laxatives, probiotics, or antibiotics within the past 1 month; having severe heart, liver, and kidney insufficiency; being pregnant or lactating women; being allergic to the test components.

[0036] Observation indicators and evaluation methods: Onset time: The time (hours) from the first intervention to the first spontaneous defecation; Defecation frequency: The number of spontaneous defecations per week (during the pre-intervention baseline period, the 1st-7th day of intervention, and the 8th-14th day after discontinuation); Safety: The incidence of adverse events such as abdominal distension, abdominal pain, and diarrhea (NCI-CTCAE 5.0 standard); Defecation maintenance after discontinuation: The proportion (%) of patients with ≥ 3 defecations per week within 4 weeks after discontinuation (the 8th-28th day). Based on the above, the verification of the laxative effect and side effects is shown in Table 1 below: Table 1

[0037] Perform statistical analysis on the above results, and the results are shown in Table 2: Table 2

[0038] , as can be seen from the above table, compared with Comparative Examples 2 to 8, Examples 1 to 3 have significant advantages in terms of onset time, defecation frequency, side effects and long-term effects. This shows that the enzyme promotes defecation, dietary fiber regulates the flora, and traditional Chinese medicine repairs the intestinal barrier, and the combination of all components has a synergistic effect. Through the synergistic effect of the enzyme and water-soluble polysaccharide dietary fiber, rapid defecation promotion is achieved. The enzyme can efficiently decompose food residues, reducing the volume of food residues and making it easier to pass through the narrow intestinal space; while water-soluble polysaccharide dietary fiber can absorb water, making the feces softer, further reducing the difficulty of passing through the intestine, and it also has a laxative effect to avoid intestinal dryness; secondly, the water-soluble dietary fiber compounded with oligosaccharides and polysaccharides has good gastrointestinal digestion resistance characteristics, can improve the relative abundance of probiotics, and promote the restoration of the intestinal microecological balance; finally, by adding medicinal and edible homologous ingredients such as Codonopsis pilosula, Astragalus membranaceus, and Cistanche deserticola, through invigorating qi and strengthening the spleen, repairing the intestinal barrier, promoting intestinal function health, ensuring long-term effects, and preventing recurrence. The laxative composition in the present application takes effect within 2 hours to 12 hours, achieves a lasting laxative effect by quickly relieving constipation, improving the relative abundance of beneficial flora and repairing damaged intestines, and can also avoid the risk of dependence on traditional laxatives.

[0039] Compared with Comparative Example 2, the onset time of Examples 1 to 3 in the present application is faster. Through statistical analysis of Example 3 and Comparative Example 2, there is a significant difference in the onset time, which proves that the addition of enzyme powder can decompose food residues, directly accelerate intestinal emptying, and improve the onset speed. After long-term administration, the defecation frequency in Comparative Example 2 began to decrease. Through statistical analysis of Example 3 and Comparative Example 2, there are significant differences in the defecation frequency in the first week and the second week, indicating that the enzyme powder cannot maintain a good defecation effect. Through the combination of the components of Examples 1 to 3 in the present application, the effect of continuously maintaining the defecation frequency can be achieved.

[0040] Compared with Comparative Example 3, the onset time of Examples 1 to 3 in the present application is faster, proving that dietary fiber has a water absorption and swelling effect and can cooperate with the enzyme to shorten the onset time. Through statistical analysis and comparison of Comparative Example 3 and Example 3, there are significant differences in the defecation frequency in the first week and the second week, and the maintenance effect of the defecation frequency has decreased significantly, indicating the irreplaceability of dietary fiber in regulating the flora and physically promoting defecation by water absorption and swelling. However, the side effects in Comparative Example 3 are significantly lower than those in Comparative Example 2 and Comparative Example 4, indicating that dietary fiber is one of the reasons for the generation of side effects.

[0041] Compared with Comparative Example 4, Examples 1 to 3 in this application have a faster onset time, significantly reduced side effects, and significantly improved long-term maintenance effects, which indicates that the addition of the Chinese medicine composition can not only enhance intestinal motility and accelerate the onset of effect by replenishing qi and strengthening the spleen, but also improve the function of the flora by repairing the intestinal barrier. After adding the Chinese medicine composition, its anti-inflammatory effect can reduce side effects such as abdominal distension caused by gas production caused by dietary fiber fermentation and diarrhea caused by oligosaccharides affecting intestinal osmotic pressure, proving the durability of the Chinese medicine composition in repairing intestinal function.

[0042] Compared with Comparative Examples 5 to 7, the indicators of Examples 1 to 3 in the present application are improved in all aspects. Statistical analysis was performed with Example 3, and there were significant differences in the onset time, the frequency of bowel movements in the first week and the second week, which proved that the use of enzyme powder, dietary fiber or Chinese medicine composition alone could not achieve a good effect on the improvement and sustained improvement of laxative effect.

[0043] In Comparative Example 8, after the first dose, defecation will continue to be promoted, but as time goes by and the number of doses increases, the defecation effect will gradually be lost. At the same time, in Comparative Example 8, side effects such as abdominal pain and diarrhea are likely to occur during defecation.

[0044] The laxative compositions described in Examples 1 to 3 of the present invention and Comparative Examples 1 to 8 were subjected to intestinal flora abundance detection. Specifically, the stomach action was first simulated: 37°C, pepsin (pH 2.0) treatment for 2 hours; then the intestinal action was simulated: pancreatic enzyme + bile salt (pH 6.8) treatment for 4 hours; and then digestion was terminated by 80°C water bath for 10 minutes. Healthy fecal flora was inoculated, fermented under anaerobic conditions at 37°C for 48 hours, and samples were taken. The relative abundance of bifidobacteria and lactobacilli was quantitatively determined by qPCR. The test results are shown in Table 3 below: Table 3 , As can be seen from the above table, compared with comparative examples 1 to 8, the laxative compositions described in Examples 1 to 3 of the present invention can continuously improve the intestinal environment and the relative abundance of beneficial bacteria, which proves the laxative effect of the laxative compositions described in Examples 1 to 3 of the present application.

[0045] In a second aspect, Example 4 of the present invention provides a use of the laxative composition described in Examples 1 to 3 above in the preparation of a product for relieving constipation and repairing intestinal function.

[0046] Preferably, the product is food or medicine, and the food is functional food or health food.

[0047] In the description of this specification, the description referring to terms such as "one embodiment", "some embodiments", "examples", "specific examples", or "some examples", etc. means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0048] The above-described embodiments merely represent several implementation manners of the present invention. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the patent for the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention shall be subject to the appended claims.

Claims

1. A laxative composition, characterized in that, Comprising the following components by weight parts: 5 parts to 10 parts of enzyme powder, 68.5 parts to 84.5 parts of dietary fiber, and 9 parts to 15 parts of traditional Chinese medicine mixture, wherein the traditional Chinese medicine mixture comprises the following components by weight parts: 3 parts to 5 parts of astragalus extract, 3 parts to 5 parts of codonopsis pilosula extract, and 3 parts to 5 parts of cistanche deserticola extract.

2. The laxative composition according to claim 1, characterized in that, The dietary fiber includes oligosaccharides and polysaccharides.

3. The laxative composition according to claim 2, wherein The oligosaccharides are the following components by weight parts: 10 parts to 12 parts of xylooligosaccharide, 20 parts to 25 parts of fructooligosaccharide, and 8 parts to 12 parts of isomaltooligosaccharide.

4. The laxative composition according to claim 2, characterized in that, The polysaccharides are the following components by weight parts: 1 part to 1.5 parts of aloe polysaccharide, 8 parts to 10 parts of galactomannan, and 21.5 parts to 24 parts of resistant dextrin.

5. The laxative composition according to claim 1, wherein The preparation method of the traditional Chinese medicine mixture includes: Putting codonopsis pilosula, astragalus, and cistanche deserticola into an extraction tank loaded with an extraction solvent respectively, and performing decoction treatment and filtration treatment to obtain codonopsis pilosula filtrate, astragalus filtrate, and cistanche deserticola filtrate; Concentrating and drying the codonopsis pilosula filtrate, the astragalus filtrate, and the cistanche deserticola filtrate respectively to obtain codonopsis pilosula extract, astragalus extract, and cistanche deserticola extract; Mixing the codonopsis pilosula extract, the astragalus extract, and the cistanche deserticola extract to form a traditional Chinese medicine mixture.

6. Use of the laxative composition according to any one of claims 1 to 4 in the preparation of a product for relieving constipation and repairing intestinal function.

7. The application according to claim 6, wherein The product is a food or a medicine.

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