Production process of packaging material of wound dressing product

Abstract

The invention relates to the technical field of medical packaging, in particular to a production process of a packaging material of a wound dressing product, which comprises the following steps: S1, selecting a polymer material with high barrier property, including purified terephthalic acid and ethylene glycol, and pretreating to obtain a processed material; s2, processing the processing material through an extrusion molding process to form a single-layer film; s3, the inner surface of the single-layer film is evenly coated with functional glue, and a packaging film is formed; s4, the packaging film is put into a drying machine for drying treatment; s5, taking out the dried packaging film, and slitting the packaging film into small rolls; s6, placing the wound dressing on the inner surface of the packaging film; according to the adhesive bandage disclosed by the invention, the nano-silver particles and the specific water blocking agent used in the functional glue enhance the antibacterial and moisture-proof capabilities of the package, so that the adhesive bandage can be kept in a sterile state even in a long-time storage process, and the service life of the product is effectively prolonged.

Description

Technical Field

[0001] The invention relates to the technical field of medical packaging, and in particular to a production process of packaging materials for wound dressing products. Background Art

[0002] With the development of the medical industry, the packaging requirements for medical drugs such as Band-Aids are becoming increasingly stringent. As a common topical drug, Band-Aids are usually used for the care and protection of small wounds. Therefore, their packaging not only needs to be moisture-proof and antibacterial, but also needs to ensure that the Band-Aids are not contaminated during long-term storage. Traditional Band-Aid packaging mostly uses paper boxes or ordinary plastic packaging. This type of packaging is easily affected by moisture in a high-humidity environment, especially in humid climatic conditions, such as the rainy season in the south. Moisture may penetrate into the packaging, causing the Band-Aid to lose its original sterile properties, affecting the use effect and safety. In addition, the sealing and airtightness inside the packaging are insufficient, and it is impossible to effectively prevent the invasion of external moisture and microorganisms, further affecting the preservation quality of the Band-Aid.

[0003] The packaging materials used for Band-Aids in the prior art still have deficiencies in terms of moisture-proof, antibacterial and airtightness. In particular, during long-term storage, the humidity control inside the package is difficult to maintain stability. The current packaging technology is difficult to ensure that the Band-Aids remain dry and sterile in a high-humidity environment, and the existing sealing process often cannot provide sufficient airtightness, resulting in the humidity level inside the package exceeding the safe range. Therefore, it is urgent to develop a new packaging process that can effectively solve the moisture-proof and antibacterial problems of Band-Aids during long-term storage and ensure their quality and safety under various environmental conditions. Summary of the invention

[0004] Based on the above purpose, the present invention provides a production process of packaging materials for wound dressing products.

[0005] A production process for packaging materials of wound dressing products, characterized in that it comprises the following steps: S1: Selecting polymer materials with high barrier properties, including purified terephthalic acid and ethylene glycol, and pre-treating them to obtain processed materials; S2: processing the processed material through an extrusion molding process to form a single-layer film; S3: evenly coating the inner surface of the single-layer film with functional glue to form a packaging film; S4: putting the packaging film into a dryer for drying; S5: taking out the dried packaging film and slitting it into small rolls; S6: placing the wound dressing on the inner surface of the packaging film; S7: rolling the packaging film of the wound dressing product so that the film covers the wound dressing to form a sealed package; S8: Conduct quality inspection on the sealed packaging to ensure that its sealing performance and moisture-proof performance meet the predetermined standards.

[0006] Preferably, the ratio of the polymer materials is that the molar ratio of purified terephthalic acid to ethylene glycol is 1:1.2.

[0007] Preferably, the specific steps of S1 include: S11: Mix purified terephthalic acid and ethylene glycol in a predetermined ratio, and simultaneously add a catalyst and a stabilizer to obtain mixture A; S12: Heat mixture A to 260 °C, with a pressure of 0.4 MPa and a heating time of 50 min to completely melt mixture A and carry out an esterification reaction to generate oligomers; S13: The oligomers carry out a polycondensation reaction under vacuum conditions to generate high molecular weight polyester resin.

[0008] Preferably, the specific steps of S2 include: S21: Feed the polyester resin into an extruder, and set the temperature of the extruder to 200 °C; S22: Control the extrusion pressure at 8 MPa; S23: Set the extrusion speed at 1.5 m / min; S24: Adjust the discharge thickness through a die head to finally form a single-layer film with a thickness of 75 μm; S25: After the film is formed, cool it to room temperature through a cooling roll; S26: Longitudinally stretch the preliminarily cooled film through a set of rollers to increase its length; S27: The film after longitudinal stretching is fed into a transverse stretching machine and transversely stretched by means of air pressure or mechanical means to increase its width; S28: The film after biaxial stretching enters a heat setting area, and the molecular chains are rearranged by high-temperature heating.

[0009] Preferably, in S5, the functional glue is composed of aqueous neoprene, nano silver particles, and a water blocking agent, where the mass ratio of aqueous neoprene, nano silver particles, and the water blocking agent is 98:0.5 - 1.5:0.5 - 1.5; the thickness of the functional glue is 3 mils; the water-based glue is coated, and the glue content is ≥ 4 g / m; the fluorescent substance is observed at wavelengths of 365 nm and 254 nm and shall not show strong blue fluorescence.

[0010] Preferably, in S11, the catalyst is antimony trioxide, and the mass of antimony trioxide is 0.01% - 0.05% of the mass of purified terephthalic acid, and the stabilizer is a phosphate ester, and the mass of the phosphate ester is 0.001% - 0.01% of the mass of purified terephthalic acid.

[0011] Advantages of the present invention: In the present invention, the nano-silver particles and specific water repellents used in the functional glue enhance the antibacterial and moisture-proof capabilities of the packaging, enabling the band-aid to maintain its sterile state even during long-term storage and effectively extending the service life of the product.

[0012] In the present invention, by adding a catalyst and setting the mass of the catalyst to 0.01% - 0.05% of the mass of purified terephthalic acid, it can promote the esterification reaction to be more complete, further improve the regularity of the polyester molecular chain, reduce the free volume, and increase the intrinsic barrier property by 15% - 20%. Further, by setting the temperature of the extruder to 200°C, the melt viscosity of the polyester resin is reduced by 12% - 15%, which is beneficial to eliminating the melt fracture phenomenon, and further reduces the surface porosity of the formed single-layer film.

[0013] The sealing and airtightness of the packaging are improved. This improved sealing technology not only ensures the stable preservation of the band-aid in a humid environment but also significantly reduces product waste caused by packaging failure, thereby enhancing the economic benefits and market competitiveness of the product. The comprehensive application of these technologies ensures the safe use of the band-aid under various climatic conditions and is of great significance for enhancing the user experience and trust of consumers. Brief Description of the Drawings

[0014] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only those of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0015] Figure 1 It is a schematic diagram of the process flow for the production and preparation of the packaging of the medicine of the present invention. Detailed Embodiments

[0016] The present invention will be described in detail below in conjunction with the drawings and specific embodiments. At the same time, it should be noted here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments. For some well-known technologies, those skilled in the art can also adopt other alternative methods for implementation; and the drawings are only for more specific description of the embodiments and are not intended to specifically limit the present invention.

[0017] It should be noted that in the specification, references to "one embodiment", "an embodiment", "exemplary embodiments", "some embodiments", etc. indicate that the described embodiments may include a particular feature, structure, or characteristic, but not necessarily every embodiment includes that particular feature, structure, or characteristic. Additionally, when combining an embodiment to describe a particular feature, structure, or characteristic, implementing such a feature, structure, or characteristic in combination with other embodiments (whether explicitly described or not) should be within the knowledge of those skilled in the relevant art.

[0018] Generally, terms can be understood at least in part from their use in context. For example, at least in part depending on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in a singular sense, or can be used to describe a combination of features, structures, or characteristics in a plural sense. Additionally, the term "based on" can be understood as not necessarily intended to convey a set of exclusive factors, but rather can alternatively, at least in part depending on the context, allow for the existence of other factors that are not necessarily explicitly described.

[0019] Embodiment 1 As Figure 1 shown, a production process for the packaging material of a wound dressing product includes the following steps: S1: Select a polymer material with high barrier properties, including purified terephthalic acid and ethylene glycol, and perform pretreatment to obtain a processed material; S2: Process the processed material through an extrusion molding process to form a single-layer film; S3: Uniformly coat a functional glue on the inner surface of the single-layer film to form a packaging film; S4: Place the packaging film in a dryer for drying treatment; S5: Take out the dried packaging film and slit it into small rolls; S6: Place the wound dressing on the inner surface of the packaging film; S7: Roll press the packaging film of the wound dressing product so that the film wraps the wound dressing to form a sealed package; S8: Conduct quality inspection on the sealed package to ensure that its sealing and moisture-proof performance meet the predetermined standards.

[0020] The ratio of the polymer materials is that the molar ratio of purified terephthalic acid to ethylene glycol is 1:1.2.

[0021] S1 specifically includes: S11: Mix purified terephthalic acid and ethylene glycol in a predetermined ratio, and simultaneously add a catalyst and a stabilizer to obtain mixture A; S12: Heat mixture A to 260 °C, with a pressure of 0.4 MPa and a heating time of 50 min, to completely melt mixture A and cause an esterification reaction to generate oligomers; S13: The oligomer undergoes a polycondensation reaction under vacuum conditions to produce a high molecular weight polyester resin.

[0022] S2 specifically includes: S21: Feed the polyester resin into an extruder, and set the extruder temperature to 200 °C; S22: Control the extrusion pressure at 8 MPa; S23: Set the extrusion speed to 1.5 m / min; S24: Adjust the discharge thickness through a die head to finally form a single-layer film with a thickness of 75 μm; S25: After the film is formed, cool it to room temperature through a cooling roller; S26: Pass the preliminarily cooled film through a set of rollers for longitudinal stretching to increase its length; S27: The longitudinally stretched film is fed into a transverse stretching machine and transversely stretched by pneumatic or mechanical means to increase its width; among them, through sufficient stretching, the polyester molecular chains are highly oriented along the biaxial direction, and then a denser lamellar crystal structure is formed.

[0023] S28: The film after biaxial stretching enters a heat setting zone, and the molecular chains are rearranged by high-temperature heating.

[0024] In S3, the functional glue is composed of aqueous neoprene, nano silver particles, and a water repellent. The mass ratio of aqueous neoprene, nano silver particles, and the water repellent is 98:0.5:1.5; the thickness of the functional glue is 3 mils; the water-based glue is coated, and the glue content is ≥ 4 g / m; the fluorescent substance is observed at wavelengths of 365 nm and 254 nm and shall not show strong blue fluorescence.

[0025] Furthermore, the above-mentioned functional glue is coated using gradient coating. First, the first layer is coated with aqueous neoprene as a primer to form an initial adhesion layer. Then, the second layer is coated with a composite layer formed by nano silver particles and a water repellent to enhance antibacterial and water repellent properties.

[0026] In S11, the catalyst is antimony trioxide, and the mass of antimony trioxide is 0.01% - 0.05% of the mass of purified terephthalic acid. The stabilizer is a phosphoric acid ester, and the mass of the phosphoric acid ester is 0.001% - 0.01% of the mass of purified terephthalic acid; Air tightness test: Place the packaged body after encapsulation in a sealing test device, set the test pressure to 80 kPa, and the duration is 10 minutes; during the test, the pressure difference is 0.2 kPa, meeting the air tightness standard ISO 11607-1; Moisture resistance test: Place the packaged body in an environment with a humidity controlled at 95% and store it for 48 hours, and test the change in its internal humidity. The specific humidity is 5%, meeting the moisture resistance requirements of ASTM D3079 standard.

[0027] Example 2 S1: Select a polymer material with high barrier properties, including purified terephthalic acid and ethylene glycol, and perform pretreatment to obtain a processing material; S2: Process the processing material through an extrusion molding process to form a single-layer film; S3: Uniformly coat a functional glue on the inner surface of the single-layer film to form a packaging film; S4: Place the packaging film in a dryer for drying treatment; S5: Take out the dried packaging film and cut it into small rolls; S6: Place the wound dressing on the inner surface of the packaging film; S7: Roll-press the packaging film of the wound dressing product so that the film wraps the wound dressing to form a sealed package; S8: Conduct quality inspection on the sealed package to ensure that its sealing and moisture-proof performance meet the predetermined standards.

[0028] The mixing ratio of the polymer material is that the molar ratio of purified terephthalic acid to ethylene glycol is 1:1.2.

[0029] S1 specifically includes: S11: Mix purified terephthalic acid and ethylene glycol in a predetermined ratio, and at the same time add a catalyst and a stabilizer to obtain a mixture A; S12: Heat the mixture A to 260 °C, with a pressure of 0.4 MPa and a heating time of 50 min, so that the mixture A is completely melted and an esterification reaction occurs to generate oligomers; S13: The oligomers undergo a polycondensation reaction under vacuum conditions to generate a high molecular weight polyester resin.

[0030] S2 specifically includes: S21: Put the polyester resin into an extruder, and set the temperature of the extruder to 200 °C; S22: Control the extrusion pressure at 8 MPa; S23: Set the extrusion speed at 1.5 m / min; S24: Adjust the discharge thickness through a die head to finally form a single-layer film with a thickness of 75 μm; S25: After the film is formed, cool it to room temperature through a cooling roll; S26: Pass the preliminarily cooled film through a set of rollers for longitudinal stretching to increase its length; S27: The longitudinally stretched film is sent into a transverse stretching machine and is transversely stretched by pneumatic or mechanical means to increase its width; S28: The film after biaxial stretching enters the heat setting zone, and the molecular chains are rearranged by high-temperature heating.

[0031] In S5, the functional glue is composed of aqueous neoprene, nano silver particles, and water repellent. The mass ratio of aqueous neoprene, nano silver particles, and water repellent is 98:1:1. The thickness of the functional glue is 3 mils. The coated water-based glue has a glue content of ≥ 4 g / m². The fluorescent substance is observed at wavelengths of 365 nm and 254 nm and shall not show strong blue fluorescence.

[0032] In S11, the catalyst is antimony trioxide, and the mass of antimony trioxide is 0.01% - 0.05% of the mass of purified terephthalic acid. The stabilizer is orthophosphate ester, and the mass of orthophosphate ester is 0.001% - 0.01% of the mass of purified terephthalic acid. For the airtightness test, the package is placed in a sealing test device, the test pressure is set at 80 kPa, the test time is 10 minutes, and the pressure difference during the process is 0.3 kPa. At the same time, for the moisture-proof performance test, the package is placed in an environment with 95% humidity for 48 hours, and the internal humidity change is measured. The specific humidity is 7% to ensure the moisture-proof property and long-term stability of the band-aid.

[0033] Example 3 S1: Select a high-barrier polymer material, including purified terephthalic acid and ethylene glycol, and perform pretreatment to obtain a processed material. S2: Process the processed material through an extrusion molding process to form a single-layer film. S3: Uniformly coat the inner surface of the single-layer film with a functional glue to form a packaging film. S4: Put the packaging film into a dryer for drying treatment. S5: Take out the dried packaging film and cut it into small rolls. S6: Place the wound dressing on the inner surface of the packaging film. S7: Roll-press the packaging film of the wound dressing product so that the film wraps the wound dressing to form a sealed package. S8: Conduct quality inspection on the sealed package to ensure that its airtightness and moisture-proof performance meet the predetermined standards.

[0034] The ratio of the polymer material is that the molar ratio of purified terephthalic acid to ethylene glycol is 1:1.2.

[0035] S1 specifically includes: S11: Mix purified terephthalic acid and ethylene glycol in a predetermined ratio, and at the same time add a catalyst and a stabilizer to obtain a mixture A. S12: Heat the mixture A to 260 °C, with a pressure of 0.4 MPa and a heating time of 50 min to completely melt the mixture A and cause an esterification reaction to generate oligomers. S13: The oligomers undergo a polycondensation reaction under vacuum conditions to produce a high molecular weight polyester resin.

[0036] S2 specifically includes: S21: Feed the polyester resin into an extruder, and set the extruder temperature to 200 °C; S22: Control the extrusion pressure at 8 MPa; S23: Set the extrusion speed to 1.5 m / min; S24: Adjust the discharge thickness through a die head to finally form a single-layer film with a thickness of 75 μm; S25: After the film is formed, cool it to room temperature through a cooling roll; S26: Pass the preliminarily cooled film through a set of rollers for longitudinal stretching to increase its length; S27: The longitudinally stretched film is fed into a transverse stretching machine and is transversely stretched by pneumatic or mechanical means to increase its width; S28: The film after biaxial stretching enters a heat setting zone, and the molecular chains are rearranged by high-temperature heating.

[0037] In S5, the functional glue is composed of aqueous neoprene, nano silver particles, and a water repellent. The mass ratio of aqueous neoprene, nano silver particles, and the water repellent is 98:1.5:0.5; the thickness of the functional glue is 3 mils; the coated water-based glue has a glue content of ≥4 g / m; the fluorescent substance is observed at wavelengths of 365 nm and 254 nm and shall not show strong blue fluorescence.

[0038] In S11, the catalyst is antimony trioxide, and the mass of antimony trioxide is 0.01% - 0.05% of the mass of purified terephthalic acid. The stabilizer is a phosphate ester, and the mass of the phosphate ester is 0.001% - 0.01% of the mass of purified terephthalic acid; For the airtightness test, place the package in a sealing test device, set the test pressure to 80 kPa, the test time to 10 minutes, and the pressure difference during the process to 0.5 kPa. At the same time, conduct a moisture-proof performance test. Place the package in an environment with a humidity of 95% for 48 hours, and test the internal humidity change. The specific humidity is 10% to ensure the moisture-proof property and long-term stability of the band-aid.

[0039] Table 1 Comparison of the performance parameters of the finished products of each example As can be seen from Table 1 above, Example 1 has the best air tightness, which is 99.5%, followed by Example 3 with 98%, while the standard package is 90%; Example 1 and Example 3 have similar moisture resistance, which are 95% and 94% respectively, while Example 2 is slightly lower at 92%, but both are significantly better than the standard package's 80%; Example 1 has the highest antibacterial property, which is 98%, while Example 2 and Example 3 are 95% and 96% respectively, which are also significantly better than the standard package's 85%; Material strength Example 1 has a material strength of 90%, Example 2 has a material strength of 88%, and Example 3 has a material strength of 96%. 89%, slightly higher than 85% of standard packaging; the packaging tightness of Example 1 and Example 3 is 97% and 96% respectively, and that of Example 2 is 95%, both better than 90% of standard packaging; the production cost of Example 1 is the highest, which is 85%, while that of Example 3 is 82%, that of Example 2 is 80%, and that of standard packaging is 70%, indicating that the cost of the new process is slightly higher; the service life of Example 1 is 24 months, that of Example 3 is 22 months, that of Example 2 is 20 months, and that of standard packaging is 12 months, which prolongs the shelf life of the product.

[0040] Table 2 Comparison of other performance parameters As can be seen from Table 2 above, the processing time of Example 1 is relatively long, which is 120 minutes, but compared with 90 minutes of the standard package, its processing technology is more complicated and the performance is significantly optimized; the energy consumption of Example 1 is 50 kWh, which is slightly higher than 40 kWh of the standard package, but considering its better performance, this energy consumption level is within an acceptable range; the material utilization rate of Example 1 is 95%, which is significantly better than 85% of the standard package, indicating that Example 1 is outstanding in the efficient utilization of materials and reduces waste; the waste generated by Example 1 is the least, only 0.5 kg, and the standard package is 1.0 kg, indicating that the new process is more environmentally friendly; the weight of the finished product of Example 1 is 10 g, which is slightly higher than 8 g of the standard package, which may be due to the additional weight brought by its composite structure, but it is also the result of improved performance; the production efficiency of Example 1 is 500 pieces / hour, compared with 460 pieces / hour of the standard package, although the process is complicated, it does not significantly reduce the production efficiency; the environmental protection index of Example 1 is 85%, which is significantly higher than 70% of the standard package, indicating that the process has advantages in reducing pollution and reducing carbon emissions.

[0041] In general, Example 1 shows better performance in many aspects, especially in terms of material utilization, waste generation and environmental protection index. Although the processing time and energy consumption are slightly higher, these efforts are exchanged for higher quality finished products and lower environmental impact, which is suitable for long-term promotion and application.

[0042] The present invention covers any alternatives, modifications, equivalent methods, and solutions made within the spirit and scope of the present invention. To enable the public to have a thorough understanding of the present invention, specific details are described in detail in the following preferred embodiments of the present invention. However, those skilled in the art can fully understand the present invention even without the description of these details. Additionally, well-known methods, processes, procedures, components, and circuits are not described in detail to avoid unnecessary confusion to the essence of the present invention.

[0043] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, several improvements and refinements can be made without departing from the principle of the present invention, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A production process for the packaging material of a wound dressing product, characterized in that, It includes the following steps: S1: Select a polymer material with high barrier properties, including purified terephthalic acid and ethylene glycol, perform pretreatment and obtain a processing material; S2: Process the processing material through an extrusion molding process to form a single-layer film from the processing material; S3: Uniformly coat a functional glue on the inner surface of the single-layer film to form a packaging film; S4: Place the packaging film in a dryer for drying treatment; S5: Take out the dried packaging film and slit it into small rolls; S6: Place the wound dressing on the inner surface of the packaging film; S7: Roll-press the packaging film of the wound dressing product so that the film wraps the wound dressing to form a sealed package; S8: Conduct quality inspection on the sealed package.

2. The production process of the packaging material for a wound dressing product according to claim 1, characterized in that, The ratio of the polymer materials is as follows: the molar ratio of purified terephthalic acid to ethylene glycol is 1:1.

2.

3. The production process of the packaging material for a wound dressing product according to claim 1, characterized in that, The specific steps of S1 include: S11: Mix purified terephthalic acid and ethylene glycol in a predetermined ratio, and at the same time add a catalyst and a stabilizer to obtain a mixture A; S12: Heat the mixture A to 260 °C, with a pressure of 0.4 MPa and a heating time of 50 min, to completely melt the mixture A and carry out an esterification reaction to generate oligomers; S13: The oligomers carry out a polycondensation reaction under vacuum conditions to generate a polyester resin with high molecular weight.

4. The production process of the packaging material for a wound dressing product according to claim 3, characterized in that, The specific steps of S2 include: S21: Put the polyester resin into an extruder, and set the temperature of the extruder to 200 °C; S22: Control the extrusion pressure at 8 MPa; S23: Set the extrusion speed at 1.5 m / min; S24: Adjust the discharge thickness through a die head to finally form a single-layer film with a thickness of 75 μm; S25: After the film is formed, cool it to room temperature through a cooling roll; S26: Pass the preliminarily cooled film through a set of rollers for longitudinal stretching to increase its length; S27: The longitudinally stretched film is fed into a transverse stretching machine and is transversely stretched by means of air pressure or mechanical means to increase its width; S28: The film after biaxial stretching enters a heat setting area, and the molecular chains are rearranged by high-temperature heating.

5. The production process of the packaging material for a wound dressing product according to claim 1, characterized in that, In S5, the functional glue is composed of aqueous neoprene, silver nanoparticles, and a water blocking agent, and the mass ratio of aqueous neoprene, silver nanoparticles, and the water blocking agent is 98:0.5 - 1.5:0.5 - 1.

5.

6. The production process of the packaging material for a wound dressing product according to claim 5, characterized in that, For the functional glue, the thickness is 3 mils; coat the water-based glue, with a glue content ≥ 4 g / m; when observed at wavelengths of 365 nm and 254 nm, the fluorescent substance shall not show strong blue fluorescence.

7. The production process of the packaging material for a wound dressing product according to claim 3, characterized in that, In S11, the catalyst is antimony trioxide, and the mass of antimony trioxide is 0.01% - 0.05% of the mass of purified terephthalic acid.

8. The production process of the packaging material for a wound dressing product according to claim 3, characterized in that, In S11, the stabilizer is a phosphoric acid ester, and the mass of the phosphoric acid ester is 0.001% - 0.01% of the mass of purified terephthalic acid.

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