Continuous production process method for preparing tyrosine

Abstract

The invention discloses a continuous production process method for tyrosine preparation, and relates to the field of tyrosine preparation, cystine refined water, liquid caustic soda, tyrosine, dilute acid, water, activated carbon, a pressing plate frame, a cystine workshop, filter residue waste activated carbon, a refined neutralization tank, a centrifugal machine, a dryer, molecular sieve cystine refined water, liquid caustic soda, a pressing plate frame, a cystine workshop, water, dilute acid and a molecular sieve. According to the method disclosed by the invention, the pH value of the refined cystine water is adjusted to 8.8 by using the caustic soda liquid, and the refined cystine water is cooled to 40 DEG C; a proper amount of water is added into a tyrosine primary crude product, the pH value is adjusted to 0.5 with dilute acid, the temperature is raised to 70 DEG C, a proper amount of molecular sieve and activated carbon are added for decoloration, filtrate is pumped into a fine neutralization tank, the filtrate tyrosine fine decoloration solution is neutralized to the pH value of 2.5, and the solution is cooled to 40 DEG C. A centrifugal machine is used for spin-drying to obtain a tyrosine fine product, so that the synthesis steps are reduced, and the production cost is reduced. And consumed raw materials are reduced.

Description

Technical Field

[0001] The present invention relates to a field, and specifically to a continuous production process method for preparing tyrosine. Background Art

[0002] Tyrosine is one of the basic units of protein synthesis. It, together with other amino acids, is connected by peptide bonds to form proteins with specific structures and functions. Tyrosine is a precursor substance for synthesizing catecholamine neurotransmitters (such as dopamine, norepinephrine, and epinephrine). In nerve cells, tyrosine is first converted into L-DOPA under the action of tyrosine hydroxylase, and then undergoes a series of enzymatic reactions to generate dopamine. Dopamine plays an important role in areas such as the nigrostriatal system in the brain and is closely related to the body's motor control, mood regulation, etc.

[0003] Existing methods for preparing tyrosine require more steps for neutralizing, filtering, and mixing the refined water of cystine, consume more raw materials for preparing tyrosine, and have a relatively low tyrosine yield. Summary of the Invention

[0004] The purpose of the present invention is to provide a continuous production process method for preparing tyrosine in order to solve the problems that more steps are required for neutralizing, filtering, and mixing the refined water of cystine, consume more raw materials for preparing tyrosine, and have a relatively low tyrosine yield.

[0005] To achieve the above purpose, the present invention provides the following technical solution: A continuous production process method for preparing tyrosine, and the formula for preparing tyrosine is as follows: 1 - 50 parts of refined water of cystine, 1 - 8 parts of liquid alkali, 1 - 7 parts of tyrosine, 1 - 5 parts of dilute acid, 1 - 5 parts of water, 1 - 8 parts of activated carbon, a pressing plate frame, a cystine workshop, filter residue waste activated carbon, a refined neutralization tank, a centrifuge, a dryer, and a molecular sieve.

[0006] Preferably, 40 parts of refined water of cystine, 8 parts of liquid alkali, a pressing plate frame, a cystine workshop, 3 parts of water, 5 parts of dilute acid, 4 parts of molecular sieve, 4 parts of activated carbon for decolorization, filter residue waste activated carbon, a refined neutralization tank, a centrifuge, and a dryer.

[0007] Preferably, 40 parts of refined water of cystine, 8 parts of liquid alkali, a pressing plate frame, a cystine workshop, 3 parts of water, 5 parts of dilute acid, 8 parts of activated carbon for decolorization, filter residue waste activated carbon, a refined neutralization tank, a centrifuge, and a dryer.

[0008] Preferably, 30 parts of refined water of cystine, 2 parts of liquid alkali, a pressing plate frame, a cystine workshop, 1 part of water, 1 part of dilute acid, 3 parts of dilute acid, 5 parts of activated carbon for decolorization, filter residue waste activated carbon, a refined neutralization tank, a centrifuge, and a dryer.

[0009] Preferably, the continuous production process method for preparing tyrosine is as follows:

[0010] S1: 40 parts of cystine refined water are adjusted to a pH of 8.8 with 8 parts of liquid caustic soda. After cooling it to 40°C, start the plate and frame press through the plate and frame to separate the liquid and solid, generating filter residue and filtrate. The filter residue is the primary crude product of tyrosine, and the filtrate is sent to the cystine workshop for reuse.

[0011] S2: Add 3 parts of appropriate water to the primary crude product of tyrosine, adjust the pH to 0.5 with 5 parts of dilute acid, then heat it to 70°C, and add 4 parts of appropriate molecular sieve and 4 parts of activated carbon for decolorization. Filter it again through the plate and frame press. Keep the filter residue, the waste activated carbon, for reuse in the cystine production, and send the filtrate to the refined neutralization tank.

[0012] S3: Neutralize the filtrate of refined and decolorized tyrosine to a pH value of 2.5, then cool it to 40°C. Centrifuge it to obtain the refined product of tyrosine, and then dry it.

[0013] Compared with the prior art, the beneficial effects of the present invention are:

[0014] 1. By adjusting the pH of cystine refined water to 8.8 with liquid caustic soda and cooling it to 40°C, then starting the plate and frame press through the plate and frame to separate the liquid and solid, generating filter residue and filtrate. The filter residue is the primary crude product of tyrosine, and the filtrate is sent to the cystine workshop for reuse. Add appropriate water to the primary crude product of tyrosine, adjust the pH to 0.5 with dilute acid, then heat it to 70°C, and add appropriate molecular sieve and activated carbon for decolorization. Filter it again through the plate and frame press. Keep the filter residue, the waste activated carbon, for reuse in the cystine production, and send the filtrate to the refined neutralization tank. Neutralize the filtrate of refined and decolorized tyrosine to a pH value of 2.5, then cool it to 40°C. Centrifuge it to obtain the refined product of tyrosine, thus reducing the synthesis steps and the consumption of raw materials.

[0015] 2. By adding appropriate molecular sieve and activated carbon, better filtration of the primary crude product of tyrosine can be achieved, eliminating the need for multiple filtrations. Detailed Embodiment

[0016] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0017] In an embodiment of the present invention, a continuous production process for preparing tyrosine, the formula for preparing tyrosine is as follows: 1-50 parts of refined cystine water, 1-8 parts of liquid alkali, 1-7 parts of tyrosine, 1-5 parts of dilute acid, 1-5 parts of water, 1-8 parts of activated carbon, a pressing plate frame, a cystine workshop, filter residue waste activated carbon, a refined neutralization tank, a centrifuge, a dryer, and molecular sieves.

[0018] 40 parts of refined cystine water, 8 parts of liquid alkali, a pressing plate frame, a cystine workshop, 3 parts of water, 5 parts of dilute acid, 4 molecular sieves, 4 parts of activated carbon for decolorization, filter residue waste activated carbon, a refined neutralization tank, a centrifuge, a dryer;

[0019] Adjust the pH of 40 parts of refined cystine water to 8.8 with 8 parts of liquid alkali. After cooling it to 40 °C, pass it through the pressing plate frame and start the pressing plate frame to separate the liquid and solid to produce filter residue and filtrate. The filter residue is the primary crude product of tyrosine, and the filtrate is sent to the cystine workshop for reuse. Put 3 parts of appropriate water into the primary crude product of tyrosine, adjust the pH to 0.5 with 5 parts of dilute acid, then heat it to 70 °C, and add 4 parts of appropriate molecular sieves and 4 parts of activated carbon for decolorization. Filter it again through the pressing plate frame, keep the filter residue waste activated carbon for reuse in cystine, send the filtrate to the refined neutralization tank, neutralize the refined decolorized tyrosine filtrate to a pH value of 2.5, then cool it to 40 °C. Spin-dry it with a centrifuge to obtain the refined tyrosine product, and then dry it;

[0020] In this embodiment: for the preparation of tyrosine, by adding appropriate molecular sieves and activated carbon, better filtration of the primary crude product of tyrosine can be achieved, without the need for multiple filtrations, and the consumption of synthesis and filtration raw materials is significantly reduced, and the tyrosine yield is also high.

[0021] 40 parts of refined cystine water, 8 parts of liquid alkali, a pressing plate frame, a cystine workshop, 3 parts of water, 5 parts of dilute acid, 8 parts of activated carbon for decolorization, filter residue waste activated carbon, a refined neutralization tank, a centrifuge, a dryer;

[0022] Adjust the pH of 40 parts of refined cystine water to 8.8 with 8 parts of liquid alkali. After cooling it to 40 °C, pass it through the pressing plate frame and start the pressing plate frame to separate the liquid and solid to produce filter residue and filtrate. The filter residue is the primary crude product of tyrosine, and the filtrate is sent to the cystine workshop for reuse. Put 3 parts of appropriate water into the primary crude product of tyrosine, adjust the pH to 0.5 with 5 parts of dilute acid, then heat it to 70 °C, and use 8 parts of activated carbon for decolorization. Filter it again through the pressing plate frame, keep the filter residue waste activated carbon for reuse in cystine, send the filtrate to the refined neutralization tank, neutralize the refined decolorized tyrosine filtrate to a pH value of 2.5, then cool it to 40 °C. Spin-dry it with a centrifuge to obtain the refined tyrosine product, and then dry it;

[0023] In this embodiment: for the preparation of tyrosine, by adjustment, the synthesis steps are reduced, and the consumption of raw materials is reduced.

[0024] 30 parts of refined cystine water, 2 parts of liquid caustic soda, plate and frame press, cystine workshop, 1 part of water, 1 part of dilute acid 1, 3 parts of dilute acid 3, 5 parts of activated carbon for decolorization, filter residue waste activated carbon, refined neutralization tank, centrifuge, dryer;

[0025] Adjust the pH of 30 parts of refined cystine water to 4.8 with 2 parts of liquid caustic soda. After cooling it to 40 °C, start the plate and frame press through the plate and frame press to separate the liquid and solid to produce filter residue and filtrate. The filter residue is the first crude product of tyrosine, and the filtrate is sent to the cystine workshop for reuse. Adjust the pH value of the first crude product of tyrosine to 1.0 with 1 part of dilute acid and start the plate and frame press. The filter residue is the second crude product of tyrosine, and the filtrate is sent to the cystine workshop for reuse. Add 1 part of appropriate water to the first crude product of tyrosine, adjust the pH value to 12 with 2 parts of liquid caustic soda, and add waste activated carbon for decolorization. Cool and filter. The filter residue waste activated carbon is sent to the cystine workshop for reuse, and the filtrate enters the acid neutralization tank. Adjust the pH of the filtrate to 8.8 with 3 parts of dilute acid, cool to 40 °C and start the plate and frame press. The filter residue is the third crude product of tyrosine, and the filtrate is sent to the cystine workshop for reuse. Add 1 part of appropriate water to the third crude product of tyrosine, neutralize it to pH 0.5 with dilute acid 1, then heat it to 70 °C, add 4 parts of appropriate activated carbon for decolorization, and the filtrate enters the refined neutralization tank of tyrosine. The filter residue waste activated carbon is reserved for reuse. Neutralize the refined decolorized liquid of tyrosine in the filtrate to pH 2.5, cool to 40 °C, and then cool it to 40 °C again. Spin-dry it with a centrifuge to obtain the refined product of tyrosine, and then dry it;

[0026] In this embodiment: The preparation of tyrosine requires too many steps, consumes more raw materials, and has a lower yield.

[0027] The above-mentioned is only the preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and should be covered within the protection scope of the present invention.

Claims

1. A method for preparing tyrosine, characterized in that, The preparation formula of tyrosine is as follows: 1-50 parts of refined cystine water, 1-8 parts of liquid caustic soda, 1-7 parts of tyrosine, 1-5 parts of dilute acid, 1-5 parts of water, 1-8 parts of activated carbon, filter press frame, cystine workshop, filter residue waste activated carbon, refined neutralization tank, centrifuge, dryer, molecular sieve.

2. The preparation of tyrosine according to claim 1, characterized in that: 40 parts of refined cystine water, 8 parts of liquid caustic soda, filter press frame, cystine workshop, 3 parts of water, 5 parts of dilute acid, 4 parts of molecular sieve, 4 parts of activated carbon for decolorization, filter residue waste activated carbon, refined neutralization tank, centrifuge, dryer.

3. A method for preparing tyrosine according to claim 1, characterized in that: 40 parts of refined cystine water, 8 parts of liquid caustic soda, filter press frame, cystine workshop, 3 parts of water, 5 parts of dilute acid, 8 parts of activated carbon for decolorization, filter residue waste activated carbon, refined neutralization tank, centrifuge, dryer.

4. A method for preparing tyrosine according to claim 1, characterized in that, 30 parts of refined cystine water, 2 parts of liquid caustic soda, filter press frame, cystine workshop, 1 part of water, 1 part of dilute acid, 3 parts of dilute acid, 5 parts of activated carbon for decolorization, filter residue waste activated carbon, refined neutralization tank, centrifuge, dryer.

5. A continuous production process method for preparing tyrosine according to claim 1, characterized in that, The continuous production process method for preparing tyrosine is as follows: S1: 40 parts of refined cystine water is adjusted to pH 8.8 with 8 parts of liquid caustic soda, and after cooling it to 40 degrees. Through the filter press frame, start the filter press frame to separate the liquid and solid to produce filter residue and filtrate. The filter residue is the first crude product of tyrosine, and the filtrate is sent to the cystine workshop for reuse. S2: Add an appropriate amount of 3 parts of water to the first crude product of tyrosine, adjust the pH to 0.5 with 5 parts of dilute acid, then heat it to 70 degrees, and add an appropriate amount of 4 parts of molecular sieve and 4 parts of activated carbon for decolorization. Filter again through the filter press frame, and keep the filter residue waste activated carbon for reuse in cystine, and send the filtrate to the refined neutralization tank. S3: Neutralize the filtrate tyrosine refined decolorized liquid to pH 2.5, and then cool it to 40 degrees. Spin-dry it with a centrifuge to obtain the tyrosine product, and then dry it.