Biomacromolecule detection device

Abstract

The invention discloses a biomacromolecule detection device which is characterized by comprising a detection base, a sample loading and positioning mechanism, a sample image capturing mechanism and a light source mechanism are arranged on the detection base, and a biomacromolecule sample to be detected is positioned through the sample loading and positioning mechanism; the light source mechanism is used for providing a lighting source for a biomacromolecule sample to be detected which is positioned and mounted on the sample loading and positioning mechanism, and the sample image capturing mechanism is used for capturing image information of the biomacromolecule sample to be detected. The method has the advantages that the core pain points of inaccurate manual interpretation and low efficiency in the traditional biomacromolecule detection are effectively solved, and the method has the advantages of high precision, flexibility and low cost.

Description

Technical Field

[0001] The present invention relates to the field of biological detection technologies, and particularly to a detection device for biological macromolecules. Background Art

[0002] In existing biological detection technologies, there are many detection products with convenient operations, such as colloidal gold test strips, non-fluorescently labeled biochips, etc. For the detection results of visible biological macromolecules to the naked eye, currently, they are basically judged manually. Manual judgment often cannot perform accurate quantitative judgment. Especially when the result shows a weak positive, due to the error of manual judgment, it is easy to lead to inconsistent results. In addition, using manual judgment is time-consuming and laborious, and the efficiency is also relatively low. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide a detection device for biological macromolecules that can reduce the error of manual judgment and provide fast and accurate detection results.

[0004] The technical solution adopted by the present invention to solve the above technical problems is as follows: A detection device for biological macromolecules includes a detection base. A sample loading and positioning mechanism, a sample image capturing mechanism, and a light source mechanism are provided on the detection base. The sample to be detected is positioned by the sample loading and positioning mechanism. The light source mechanism provides an illumination light source for the sample positioned on the sample loading and positioning mechanism, and the image information of the sample is captured by the sample image capturing mechanism; The sample loading and positioning mechanism includes a loading carrier and a positioning seat. The positioning seat has an inner cavity and an image information capturing port provided at the front end and communicating with the inner cavity. The loading carrier is inserted into the inner cavity to align the sample with the image information capturing port. The light source mechanism is provided in the inner cavity and is located in front of the loading carrier; The sample image capturing mechanism includes a mobile phone with detection software and a mobile phone positioning bracket. The mobile phone positioning bracket includes a shooting calibration frame detachably provided on the positioning seat. The shooting calibration frame has a through cavity, and left and right framing pieces are slidably provided in the through cavity to form an adjustable image capturing hole; A limiting mechanism for limiting the left and right framing pieces is provided on the positioning seat to align the image capturing hole with the image information capturing port.

[0005] A positioning slot for positioning and installing the loading carrier into the inner cavity is provided on the positioning seat. The loading carrier is inserted into the positioning seat through the positioning slot to align the sample to be detected with the image information capturing port.

[0006] A filter is detachably provided on the image information capture port.

[0007] The filter has a mounting frame. The filter is installed within the mounting frame. The mounting frame is detachably embedded within the image information capture port. The area corresponding to the filter is the image information capture area. The loading carrier is inserted into the positioning seat through the positioning slot to align the sample to be detected with the image information capture area.

[0008] Positioning mounting posts with internal threaded holes are provided within the image information capture port. The filter is detachably mounted on the image information capture port by screwing a positioning screw, which passes through a corresponding mounting hole provided on the mounting frame, onto the positioning mounting post.

[0009] The light source mechanism is a multi-wavelength LED light bar.

[0010] Various LED patch lamp beads with different wavelengths are provided within the LED light bar. Different lamp beads can be controlled to emit light through a control circuit as needed to emit light of a fixed wavelength for exciting different fluorescent substances in the biological macromolecule sample to be detected. For example, light with wavelengths of 375nm and 480nm can correspondingly excite SYBR Green I fluorescent substances.

[0011] The mobile phone positioning bracket further includes a supporting bracket. The shooting calibration frame is used to align the camera of the mobile phone with the image information capture port. The supporting bracket is used to support the bottom of the mobile phone. The supporting bracket is adjustably arranged up and down on the detection base.

[0012] The limiting mechanism includes a left limiting tab protruding from the front end face of the positioning seat for limiting the left framing piece and a right limiting tab for limiting the right framing piece. The image information capture port is located between the left limiting tab and the right limiting tab. An upper limiting plate for upper limiting installation of the shooting calibration frame and a lower limiting plate for lower limiting installation of the shooting calibration frame are protruding from the front end face of the positioning seat. After installation, the shooting calibration frame is embedded between the upper limiting plate and the lower limiting plate. The left framing piece is attached to the outer side of the left limiting tab, and the right framing piece is attached to the outer side of the right limiting tab.

[0013] The middle parts of the left framing piece and the right framing piece respectively bulge outwards to form arc-shaped protruding parts. The two protruding parts are arranged in mirror symmetry. The left limiting tab and the right limiting tab are arc-shaped pieces that cooperate with each other.

[0014] The upper inner end face and the lower inner end face of the through cavity are respectively provided with sliding grooves in the left - right direction. The upper and lower ends of the left framing piece and the right framing piece are respectively slidably installed in the corresponding sliding grooves. At least one of the sliding grooves is detachably provided with locking buckles for respectively locking the sliding positions of the left framing piece and the right framing piece. After installation, the inner and outer sides of the left framing piece are respectively limited by the corresponding locking buckles and the left limiting tabs, and the inner and outer sides of the right framing piece are respectively limited by the corresponding locking buckles and the right limiting tabs.

[0015] The shooting calibration frame is composed of two relatively movable clamping arms in the left - right direction. An elastic reset element is arranged between the two clamping arms, and a clamping cavity for clamping the mobile phone is formed between the two clamping arms.

[0016] The elastic reset element is a reset spring.

[0017] A guide rod is arranged on the detection base, and a matching guide hole is arranged on the support bracket. Through the cooperation of the guide hole and the guide rod, the up - and - down height position adjustment installation of the support bracket on the detection base is realized. A locking mechanism for locking the position of the support bracket is arranged between the support bracket and the detection base.

[0018] The locking mechanism includes a locking bolt and a locking plate. The locking plate is arranged in the detection base. A matching sliding groove for slidably installing the locking plate is arranged in the detection base along the moving direction of the support bracket. The locking plate is slidably arranged in the sliding groove and can move synchronously with the support bracket. A locking screw hole for cooperating with the locking bolt is arranged on the locking plate. A guide groove communicating with the sliding groove is arranged on the front end face of the detection base along the moving direction of the support bracket. The locking bolt is arranged on the support bracket, and the rod part of the locking bolt passes through the guide groove and is screwed on the locking plate. In the locked state, the locking bolt is in a tightened state, so that the head of the locking bolt presses on the front end face of the support bracket, and the rear end face of the support bracket abuts against the detection base.

[0019] A concave cavity is recessed backward at the front part of the detection base, and the guide rod is installed in the concave cavity.

[0020] The positioning seat is obliquely supported on the detection base. The guide rod is obliquely arranged on the detection base, and the inclination installation angles of the positioning seat and the guide rod are the same.

[0021] A rechargeable battery is provided inside the detection base, and a charging interface adapted thereto is provided on the detection base.

[0022] A lighting control circuit is provided inside the detection base, and a lighting control switch electrically connected to the lighting control circuit is provided on the detection base.

[0023] Compared with the prior art, the advantages of the present invention are as follows: This device effectively solves the core pain points of inaccurate manual interpretation and low efficiency in traditional biological macromolecule detection, and has the advantages of high precision, flexibility, and low cost, specifically manifested as follows: (1) By combining the image capture mechanism (mobile phone camera) with the detection software to replace manual interpretation, the problem of difficult quantification of weak positive results is solved, and human error is significantly reduced; (2) The light source mechanism adopts multi-wavelength LED light strips (such as 375nm, 480nm), which can be adapted to different fluorescent markers (such as SYBR Green I) to achieve specific excitation and improve the detection sensitivity and accuracy; (3) The filter is detachably installed in the image information capture port through the installation frame, and can be adapted to different fluorescence detection requirements to achieve rapid replacement of the adapted filter; (4) By combining the positioning slot and the image information capture port with the shooting calibration frame, they cooperate with each other to ensure that the sample to be tested is aligned with the mobile phone camera, avoiding operation deviation; (5) Using the mobile phone camera as the core of image capture, through the shooting calibration frame (including a slidable clamping arm and an elastic reset spring), it is adapted to the clamping of mobile phones of different sizes to ensure stable shooting; (6) The mobile phone is installed with a compatible detection software to realize the automation of image analysis and improve efficiency; (7) The support bracket realizes fine height adjustment through the guide rod and the locking bolt, adapting to different mobile phone sizes and user operation habits; (8) The positioning seat is inclined at the same angle as the guide rod, which is convenient for observation and operation; (9) It is equipped with a rechargeable battery and a lighting control circuit inside, supporting use in outdoor or power-free environments, enhancing practicality; (10) The light source mechanism is placed in the front, suitable for use in fluorescence detection scenarios, optimizing the fluorescence signal; (11) The design of the limit tab and the split frame provides multi-dimensional calibration (left and right, up and down), significantly improving the alignment accuracy between the mobile phone camera and the sample plane. It is possible to relatively quickly determine the position of the camera of the mobile phone to be used. After locking, then position and install the shooting calibration frame on the positioning seat. After such installation, there is no need to adjust the position when the mobile phone is placed on it. It is a visual adjustment and the adjustment is relatively fast. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 Schematic diagram of the three-dimensional structure of the present invention without a mobile phone installed and without a loading carrier inserted; Figure 2 Schematic diagram of the three-dimensional structure of the shooting calibration frame in the present invention; Figure 3 is Figure 1 Schematic diagram of the three-dimensional structure with the mobile phone positioning bracket removed; Figure 4 Schematic diagram of the three-dimensional structure of the support bracket in the present invention; Figure 5 Schematic cross-sectional structure diagram of the present invention without a mobile phone installed and with a loading carrier inserted; Figure 6 Schematic diagram of the three-dimensional structure of one of the loading carriers used in the present invention; Figure 7 Schematic rear view structure diagram of the present invention without a mobile phone installed and with a loading carrier inserted. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0025] The present invention will be further described in detail below with reference to the embodiments in the drawings.

[0026] As shown in the figure, a detection device for biological macromolecules includes a detection base 1. A sample loading and positioning mechanism, a sample image capturing mechanism, and a light source mechanism are provided on the detection base 1. The biological macromolecule sample to be detected is positioned by the sample loading and positioning mechanism, and the light source mechanism provides an illumination light source for the biological macromolecule sample to be detected positioned on the sample loading and positioning mechanism. The image information of the biological macromolecule sample to be detected is captured by the sample image capturing mechanism.

[0027] In this specific embodiment, the sample loading and positioning mechanism includes a loading carrier 21 for loading the biological macromolecule sample to be detected and a positioning seat 22 for realizing the positioning and installation of the loading carrier 21. The positioning seat 22 has an inner cavity 221. An image information capture port (not shown in the figure) communicating with the inner cavity 221 is provided on the front end face of the positioning seat 22. A positioning slot 223 is provided on the positioning seat 22 for the loading carrier 21 to be positioned and installed into the inner cavity 221. The loading carrier 21 is inserted into the positioning seat 22 through the positioning slot 223 to align the biological macromolecule sample to be detected with the image information capture port. The light source mechanism is arranged in the inner cavity 221 and irradiates backward onto the loading carrier 21 before the positioning slot 223. The structure is simple. The loading carrier 21 is used to load the biological macromolecule sample to be detected, which can be a colloidal gold test strip, a fluorescence-labeled chip, etc. The stable positioning and alignment installation of the loading carrier 21 are realized through the positioning slot 223, ensuring that the biological macromolecule sample to be detected can be aligned with the image information capture port, facilitating the sample image capture mechanism to accurately obtain the effective information of the biological macromolecule sample to be detected.

[0028] In this specific embodiment, a filter 5 is detachably arranged on the image information capture port. The filter 5 is used for selective light transmission to improve the specificity of detection. It is adapted to be used in the fluorescence detection scenario. When the sample to be detected is fluorescently labeled (such as SYBR Green I), the filter 5 allows the emission light of a specific wavelength to pass through, while blocking the excitation light and other stray light. For example: the excitation light wavelength is 375 nm (emitted by an LED strip), and the emission light wavelength is 480 nm (emitted by a fluorescent substance). Then the filter 5 (such as a 480 nm band-pass filter) will block the 375 nm excitation light and only allow the 480 nm fluorescence signal to enter the mobile phone camera, significantly improving the signal-to-noise ratio. It is adapted to be used in the colorimetric detection scenario. For example, in non-fluorescent detections such as colloidal gold test strips, the filter 5 can filter out environmental light interference (such as ultraviolet or infrared light) to ensure the true restoration of the color development result. The filter 5 is detachably installed, and the replacement of the filter 5 that is adaptively matched to different usage requirements can be quickly realized, avoiding problems such as cross-contamination or wavelength limitation caused by a fixed filter, thereby improving the versatility of the device.

[0029] In this specific embodiment, the filter 5 has an installation frame 51. The filter 5 is installed in the installation frame 51. The installation frame 51 is detachably embedded in the image information capture port. The area corresponding to the filter 5 is the image information capture area. The loading carrier 21 is inserted into the positioning seat 22 through the positioning slot 223 to align the biological macromolecule sample to be detected with the image information capture area. The accurate positioning of the filter 5 is ensured through the installation frame 51, avoiding light leakage or deviation from affecting the imaging quality; the detachable structure facilitates the cleaning or replacement of a damaged filter 5, reducing the maintenance cost.

[0030] In this specific embodiment, a positioning and mounting post 6 with an internal threaded hole is provided inside the image information capture port. The filter 5 is detachably mounted on the image information capture port by a mating positioning screw 7 passing through a corresponding mounting hole provided on the mounting frame 51 and being screwed onto the positioning and mounting post 6. The structure is simple and the disassembly and assembly are convenient.

[0031] In this specific embodiment, the light source mechanism is a multi-wavelength LED light bar 41 disposed in the inner cavity 221. Integrating multi-wavelength light sources (such as 375 nm, 480 nm) into a single light bar saves space and supports multi-mode detection (such as fluorescence / ultraviolet). Compared with traditional single-color light sources, it has higher flexibility and can be adapted to different markers (such as SYBR Green I, FITC).

[0032] In this specific embodiment, various LED patch lamp beads with different wavelengths are provided inside the LED light bar 41. Different lamp beads can be controlled to emit light through a control circuit as needed to emit light of a fixed wavelength for exciting different fluorescent substances in the biological macromolecule sample to be measured. Programmed control of different lamp beads to emit light realizes automatic wavelength switching, reduces manual intervention errors; precisely matches the excitation requirements of fluorescent substances (such as 375 nm for exciting SYBR Green I), and improves the signal-to-noise ratio.

[0033] In this specific embodiment, the sample image capture mechanism is a mobile phone (not shown in the figure) with a shooting function and equipped with a suitable detection software, and a mobile phone positioning bracket. The mobile phone positioning bracket includes a shooting calibration frame 321 for aligning the camera of the mobile phone (not shown in the figure) with the image information capture port and a supporting bracket 322 for supporting the bottom of the mobile phone (not shown in the figure). The shooting calibration frame 321 is detachably disposed on the positioning seat 22, and the supporting bracket 322 is adjustably disposed up and down on the detection base 1. Utilizing the mobile phone camera and computing resources reduces the hardware cost and is compatible with existing intelligent devices at the same time; the bracket design ensures that the camera is aligned with the sample, avoiding image blurring or angle deviation caused by hand-held shooting.

[0034] In this specific embodiment, the shooting calibration frame 321 has a through cavity 323 that penetrates from front to back. A left framing piece 324 and a right framing piece 325 are slidably arranged left and right in the through cavity 323. An image capture hole 326 is formed between the left framing piece 324 and the right framing piece 325. On the front end face of the positioning seat 22, a left limiting tab 327 for limiting the left framing piece 324 and a right limiting tab 328 for limiting the right framing piece 325 are convexly provided. The image information capture port is located between the left limiting tab 327 and the right limiting tab 328. On the front end face of the positioning seat 22, an upper limiting plate 329 for forming an upper limiting installation for the shooting calibration frame 321 and a lower limiting plate 330 for forming a lower limiting installation for the shooting calibration frame 321 are convexly provided; after installation, the shooting calibration frame 321 is embedded between the upper limiting plate 329 and the lower limiting plate 330. The left framing piece 324 is attached to the outer side of the left limiting tab 327, and the right framing piece 325 is attached to the outer side of the right limiting tab 328. The slidable left / right framing pieces are adapted to the positions of the cameras of different mobile phones to ensure that the capture area completely coincides with the sample detection area; the limiting tabs provide physical stops to prevent the frame from moving excessively and thus affecting the calibration accuracy.

[0035] In this specific embodiment, the middle parts of the left framing piece 324 and the right framing piece 325 respectively bulge outwards to form arc-shaped protruding parts 331. The two protruding parts 331 are arranged in mirror symmetry. The left limiting tab 327 and the right limiting tab 328 are arc-shaped sheet bodies that cooperate with each other. The arc-shaped structure fits the outer shape of the mobile phone camera, enhancing stability and avoiding scratching the device; the mirror symmetry design simplifies the operation process, and the left and right adjustment logics are the same.

[0036] In this specific embodiment, on the upper and lower inner end faces of the through cavity 323, chutes 332 are respectively arranged in the left-right direction. The upper and lower ends of the left framing piece 324 and the right framing piece 325 are respectively slidably installed in the corresponding chutes 332. In at least one chute 332, locking buckles 333 for respectively locking the sliding positions of the left framing piece 324 and the right framing piece 325 are detachably provided; after installation, the inner and outer sides of the left framing piece 324 are respectively limited by the corresponding locking buckles 333 and the left limiting tab 327, and the inner and outer sides of the right framing piece 325 are respectively limited by the corresponding locking buckles 333 and the right limiting tab 328. The chutes 332 enable stepless adjustment, and the locking buckles 333 provide quick fixation, taking into account flexibility and reliability; preventing the framing pieces from accidentally sliding during the detection process and ensuring the consistency of image acquisition.

[0037] In this specific embodiment, the photographing calibration frame 321 is composed of two clamping arms 334 that can move left and right relatively. An elastic reset element 335 is arranged between the two clamping arms 334, and a clamping cavity for clamping a mobile phone (not shown in the figure) is formed between the two clamping arms 334. Through the elastic reset element, it can automatically adapt to the widths of different mobile phones without manual adjustment of the clamping force; the design of the clamping cavity is compatible with the mainstream mobile phone sizes, improving the user experience.

[0038] In this specific embodiment, the elastic reset element is a reset spring. It has a simple structure, low cost, and stable use.

[0039] In this specific embodiment, a guide rod 8 is arranged on the detection base 1, and a matching guide hole 9 is arranged on the support bracket 322. The adjustment and installation of the vertical height position of the support bracket 322 on the detection base 1 are realized through the cooperation of the guide hole 9 and the guide rod 8. A locking mechanism for locking the position of the support bracket 322 is arranged between the support bracket 322 and the detection base 1. The cooperation of the guide rod 8 and the guide hole 9 realizes precise vertical adjustment and movement, ensuring the best focusing distance between the mobile phone camera and the sample plane.

[0040] In this specific embodiment, the locking mechanism includes a locking bolt 101 and a locking plate 102. The locking plate 102 is arranged inside the detection base 1. A matching sliding groove 103 for the sliding installation of the locking plate 102 is arranged inside the detection base 1 along the moving direction of the support bracket 322. The locking plate 102 is slidably arranged in the sliding groove 103 and can move synchronously with the support bracket 322. A locking screw hole (not shown in the figure) matching the locking bolt 101 is arranged on the locking plate 102. A guide groove 104 communicating with the sliding groove 103 is arranged on the front end face of the detection base 1 along the moving direction of the support bracket 322. The locking bolt 101 is arranged on the support bracket 322, and the rod portion of the locking bolt 101 passes through the guide groove 104 and is screwed onto the locking plate 102. In the locked state, the locking bolt 101 is in a tightened state, so that the head of the locking bolt 101 presses on the front end face of the support bracket 322, realizing that the rear end face of the support bracket 322 abuts against the detection base 1. The above-mentioned locking mechanism has a simple structure and is convenient to operate. The sliding groove 103 provides a stable installation and positioning for the locking plate 102 and plays a role of guiding the movement at the same time.

[0041] In this specific embodiment, a concave cavity 11 is recessed backward in the front part of the detection base 1, and the guide rod 8 is installed in the concave cavity 11. The space of the detection base 1 is reasonably utilized. The concave cavity 11 hides the guide rod 8, reduces external structural interference, and improves the overall aesthetics and safety of the device.

[0042] In this specific embodiment, the positioning seat 22 is obliquely supported on the detection base 1, and the guide rod 8 is obliquely arranged on the detection base 1. The positioning seat 22 and the guide rod 8 have the same inclined installation angle. A unified inclination angle (such as 60°) optimizes the user's perspective, reduces reflection interference and facilitates operation; the structural design logic is consistent, reducing the assembly complexity.

[0043] In this specific embodiment, a rechargeable battery 12 is arranged inside the detection base 1, and a charging interface 13 adapted thereto is arranged on the detection base 1. It gets rid of the limitation of external power supply and supports continuous use in the wild or mobile scenarios; the charging interface 13 is standardized (such as Type-C) and is compatible with common charging devices.

[0044] In this specific embodiment, a lighting control circuit is arranged inside the detection base 1, and a lighting control switch 15 electrically connected to the lighting control circuit is arranged on the detection base 1. The independent switch controls the LED light strip 41, avoiding accidental touch or standby power consumption, prolonging the battery life; a mode switching function (such as constant light / pulsed light source) can be integrated to adapt to different detection protocols.

[0045] The specific operation and use process of this device is as follows: (1) Device assembly: Place the detection base 1 on a stable tabletop to ensure that the light source mechanism (LED light strip 41) and the positioning seat 22 are firmly connected; If the filter 5 needs to be used, select a suitable filter 5 (suitable for different fluorescence detection requirements), align the mounting frame 51 of the filter 5 with the image information capture port, and fix it with the positioning screw 7 to install the filter 5 into the image information capture port; (2) Mobile phone installation: Place the mobile phone installed with the adapted detection software on the mobile phone positioning bracket, adjust the clamping arm 334 to clamp the mobile phone, adjust the height of the support bracket 322 (through the guide rod 8 and the locking bolt 101), and at the same time adapt to the camera positions of different mobile phones by sliding the left / right framing pieces. After the adjustment is completed, fix the position with the locking buckle 333 to ensure that the camera is aligned with the image information capture port; (3) Sample loading: Put the biological macromolecule sample to be detected into the adapted loading carrier 21 (such as colloidal gold test strip, fluorescence-labeled chip, etc.), and insert the loading carrier 21 into the corresponding positioning slot 223 to ensure that the sample detection area is facing the image information capture port; If the sample needs fluorescence excitation, select the LED lamp beads of the corresponding wavelength through the lighting control switch (such as 375nm to excite SYBR Green I); (4) Detection process: Start the detection software (pre-installed on the mobile phone side), and adjust the camera parameters (such as exposure, white balance); Turn on the light source, and the LED light bar irradiates the sample to excite the fluorescence signal (if applicable); Click the image capture button in the software to take a high-definition image of the sample detection area; (5)Data analysis: The detection software automatically analyzes the image: For colloidal gold test strips, identify the color development intensity of the T / C lines and calculate the concentration ratio; For fluorescently labeled samples, analyze the fluorescence signal intensity and generate a quantitative report; The software can save the detection results and support comparison or export of historical data.

[0046] (6)Equipment maintenance: After the detection is completed, take out the sample and clean the positioning slot 223 and the filter 5 (to avoid contamination); Turn off the LED light source and disconnect the power supply (if not used for a long time); Regularly check the battery power of the battery 12 and replenish the power through the charging interface 13.

Claims

1. A detection device for biological macromolecules, comprising a detection base, on which a sample loading and positioning mechanism, a sample image capturing mechanism and a light source mechanism are provided. The sample to be detected is positioned by the sample loading and positioning mechanism, the light source mechanism provides an illumination light source for the sample positioned on the sample loading and positioning mechanism, and the image information of the sample is captured by the sample image capturing mechanism. It is characterized in that: The sample loading and positioning mechanism includes a loading carrier and a positioning seat. The positioning seat has an inner cavity and an image information capturing port provided at the front end and communicating with the inner cavity. The loading carrier is inserted into the inner cavity so that the sample is aligned with the image information capturing port. The light source mechanism is arranged in the inner cavity and in front of the loading carrier; The sample image capturing mechanism includes a mobile phone with detection software and a mobile phone positioning bracket. The mobile phone positioning bracket includes a shooting calibration frame detachably arranged on the positioning seat. The shooting calibration frame has a through cavity, and left and right framing pieces are slidably arranged in the through cavity left and right to form an adjustable image capturing hole; A limiting mechanism is arranged on the positioning seat for limiting the left and right framing pieces so that the image capturing hole is aligned with the image information capturing port.

2. The detection device for a biological macromolecule according to claim 1, characterized in that A positioning slot is arranged on the positioning seat for the loading carrier to be positioned and installed into the inner cavity. The loading carrier is inserted into the positioning seat through the positioning slot so that the sample to be detected is aligned with the image information capturing port.

3. The detection device for a biological macromolecule according to claim 2, characterized in that A filter is detachably arranged on the image information capturing port.

4. The detection device for a biological macromolecule according to claim 3, characterized in that The filter has an installation frame. The filter is installed in the installation frame, and the installation frame is detachably embedded in the image information capturing port. The area corresponding to the filter is the image information capturing area. The loading carrier is inserted into the positioning seat through the positioning slot so that the sample to be detected is aligned with the image information capturing area.

5. The detection device for a biological macromolecule according to claim 1, characterized in that The light source mechanism is a multi-wavelength LED light bar.

6. The detection device for a biological macromolecule according to claim 1, characterized in that The mobile phone positioning bracket further includes a support bracket. The shooting calibration frame is used to align the camera of the mobile phone with the image information capturing port. The support bracket is used to support the bottom of the mobile phone, and the support bracket is adjustably arranged up and down on the detection base.

7. The detection device for a biological macromolecule according to claim 1, characterized in that The limiting mechanism includes a left limiting tab protruding from the front end face of the positioning seat for limiting the left framing piece and a right limiting tab for limiting the right framing piece. The image information capturing port is located between the left limiting tab and the right limiting tab. An upper limiting plate for forming an upper limit installation for the shooting calibration frame and a lower limiting plate for forming a lower limit installation for the shooting calibration frame are protrudingly arranged on the front end face of the positioning seat; after installation, the shooting calibration frame is embedded between the upper limiting plate and the lower limiting plate, the left framing piece is attached to the outer side of the left limiting tab, and the right framing piece is attached to the outer side of the right limiting tab.

8. The detection device for a biological macromolecule according to claim 7, characterized in that Upper and lower inner end faces of the through cavity are respectively provided with sliding grooves in the left-right direction. Upper and lower ends of the left framing piece and the right framing piece are respectively slidably installed in the corresponding sliding grooves. At least one of the sliding grooves is detachably provided with locking latches respectively for locking sliding positions of the left framing piece and the right framing piece. After installation, the inner and outer sides of the left framing piece are respectively limited by the corresponding locking latches and the left limiting tabs, and the inner and outer sides of the right framing piece are respectively limited by the corresponding locking latches and the right limiting tabs.

9. The detection device for a biological macromolecule according to claim 6, characterized in that The detection base is provided with guide rods, and the support bracket is provided with adaptively matched guide holes. Through the cooperation of the guide holes and the guide rods, the up-and-down height position of the support bracket on the detection base is adjusted and installed. A locking mechanism for locking the position of the support bracket is provided between the support bracket and the detection base.

10. The detection device for a biological macromolecule according to claim 9, characterized in that The locking mechanism includes a locking bolt and a locking plate. The locking plate is arranged in the detection base. A sliding groove adaptively matched for sliding installation of the locking plate is arranged in the detection base along the moving direction of the support bracket. The locking plate is slidably arranged in the sliding groove and can move synchronously with the support bracket. A locking screw hole matched with the locking bolt is arranged on the locking plate. A guide groove communicating with the sliding groove is arranged on the front end face of the detection base along the moving direction of the support bracket. The locking bolt is arranged on the support bracket, and the rod portion of the locking bolt passes through the guide groove and is screwed on the locking plate. In the locked state, the locking bolt is in a tightened state, so that the head of the locking bolt presses on the front end face of the support bracket, and the rear end face of the support bracket abuts against the detection base.

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