Device and method for detecting blockage and emptying of reaction cup of blood analyzer

Abstract

The invention relates to the technical field of blood detection and analysis, in particular to a blood analyzer reaction cup blocking and emptying detection device and method.The blood analyzer reaction cup blocking and emptying detection device comprises a reaction cup, a pressure sensor, a two-way electromagnetic valve, a first isolation tank, a second isolation tank and a pump body; small negative pressure is produced in the first isolation tank and the second isolation tank, the two-way electromagnetic valve is opened, the pump body is closed after the two-way electromagnetic valve is opened for a period of time, the two-way electromagnetic valve is closed after waiting for a period of time, the negative pressure in the second isolation tank can extract liquid in the reaction cup, and if the liquid is completely pumped, the isolation cup is in direct contact with the atmosphere. The pressure sensor detects the pressure in the first isolation tank, and if the detected pressure is smaller than a pressure threshold value, the reaction cup is slightly blocked or blocked. If the detection pressure is larger than the pressure threshold value, it is considered that instrument emptying is normal, sample separation testing can be continued, cup emptying detection is conducted again after testing is finished, and it is ensured that the instrument is normal.

Description

Technical Field

[0001] The present invention relates to the technical field of blood test analysis, and particularly to a detection device and method for clogging and emptying of reaction cups of a hematology analyzer. Background Art

[0002] A hematology analyzer measures the content of cells in blood to provide clinical guidance for doctors. During the test process, the blood sample and reagents are mixed, incubated and tested in a reaction cup. After the test is completed, the instrument will clean and empty the reaction cup. Then continue with the next test. Since there are a large number of platelets and proteins in the blood, they will gradually coagulate over time. If the instrument is not cleaned thoroughly enough, or as the sample volume is continuously tested and the reaction cup ages and wears, there may be protein residues inside the reaction cup. As the amount of protein residue accumulates, it will eventually cause the reaction cup or pipeline to be blocked, resulting in instrument failure and liquid overflow and leakage of the instrument.

[0003] The common way to discharge the waste liquid from the reaction cup is to directly extract it using a pump, turn on the pump for a certain period of time and then turn off the pump, and estimate the completion of the waste liquid discharge through time. If only the pump is turned on and off, it cannot be confirmed whether the waste liquid in the reaction cup has been emptied. Under normal conditions of the instrument, turning on the pump for 1 second can empty the reaction cup. In the case of slight blockage of the instrument, it may take 2 seconds or longer to empty the reaction cup by turning on the pump. If the abnormality of the reaction cup and its pipeline cannot be identified. If this hidden danger cannot be identified in advance and the instrument continues to work, it will exacerbate the degree of blockage of the reaction cup of the instrument, and will also lead to incorrect clinical result information being provided to the doctor, bringing unnecessary troubles to the doctor's work. Summary of the Invention

[0004] The purpose of the present invention is to provide a detection device and method for clogging and emptying of reaction cups of a hematology analyzer, aiming to detect abnormal liquid discharge or blockage of the reaction cup through the change of pressure, prevent the instrument from performing sample tests in the case of abnormal discharge of the reaction cup, waste reagents, and cause other fault problems of the instrument.

[0005] To achieve the above object, in a first aspect, the present invention provides a detection device for clogging and emptying of reaction cups of a hematology analyzer, including a reaction cup, a pressure sensor, a two-way solenoid valve, a first isolation tank, a second isolation tank and a pump body; the two-way solenoid valve is respectively connected to the reaction cup, the pump body and the second isolation tank, and the pressure sensor, the first isolation tank and the second isolation tank are connected in sequence.

[0006] Wherein, the first isolation tank has an upper interface and a lower interface, the upper interface is located at the top of the first isolation tank, the lower interface is located at the bottom of the first isolation tank, and the first isolation tank and the second isolation tank have the same structure.

[0007] Among them, the volumes of the first isolation tank and the second isolation tank are 4 ml.

[0008] In a second aspect, the present invention also provides a method for detecting clogging and emptying of reaction cups of a hematology analyzer, which is applied to the device for detecting clogging and emptying of reaction cups of a hematology analyzer as described in the first aspect above, and includes the following steps;

[0009] Open the pump body to create a small negative pressure in the first isolation tank and the second isolation tank, and detect the negative pressure in the first isolation tank and the second isolation tank through a pressure sensor;

[0010] Open the two-way solenoid valve for 1 second, close the pump body, wait for 0.5 s, and then close the two-way solenoid valve, and detect the pressure in the first isolation tank through a pressure sensor;

[0011] Compare the pressure value of the first isolation tank with a pressure threshold. If the pressure value of the first isolation tank is less than the pressure threshold, the reaction cup is slightly clogged or blocked. At this time, the instrument gives an alarm prompt and stops counting.

[0012] Among them, the pressure threshold is defined as relative atmospheric pressure - 5 kPa.

[0013] A device for detecting blockage and emptying of reaction cups in a hematology analyzer. The bottom of the reaction cup is connected to one section of the two-way valve through a liquid path pipeline. The pipeline then extends from the other end of the two-way valve and is branched into two paths. One path is connected to the pump body, and waste liquid is discharged through the pump body. The other path is connected to the second isolation tank. The second isolation tank is connected to the first isolation tank, and the first isolation tank is connected to the pressure sensor. When the hematology analyzer performs a sample test, before the sample is added to the reaction cup, the pump body is turned on in advance to create a small negative pressure in the first isolation tank and the second isolation tank. Then, the two-way solenoid valve is opened. After a period of time, for example, 1 second, the pump body is turned off. After waiting for a period of time, for example, 0.5 s, the two-way solenoid valve is turned off. Since the two-way solenoid valve is not immediately turned off when the pump body is turned off, the negative pressure in the second isolation tank will continue to extract the liquid in the reaction cup. Assuming the liquid has been drained, at this time, the first isolation tank and the second isolation tank are in direct contact with the atmosphere, and the negative pressure in the first isolation tank and the second isolation tank will be released to the atmospheric pressure. The pressure in the first isolation tank is detected by the pressure sensor, which is theoretically the atmospheric pressure. The pressure threshold is defined as relative atmospheric pressure - 5 kPa. If the pressure detected in the first isolation tank is less than - 5 kPa at this time, the reaction cup is slightly blocked or blocked, and the instrument will alarm and stop counting. If the pressure in the first isolation tank is greater than - 5 kPa, close to or equal to the atmospheric pressure, it is considered that the instrument is emptied normally. At this time, the sample can be further divided and tested. After the test is completed, an emptying detection of another cup is performed again to ensure the normal operation of the instrument. This device can improve the reliability of the instrument, timely identify abnormal drainage of the reaction cup, stop losses, prevent other fault problems from occurring, save costs, stop the test in time during abnormalities, save reagents and reduce the use cost. The pump body is turned on in advance before discharging waste liquid to create a negative pressure in the first isolation tank and the second isolation tank in advance, which improves the efficiency and speed of waste liquid discharge. The first isolation tank and the second isolation tank are small in volume and fast in pressure building time. The negative pressure formed promotes the pumping and discharging of waste liquid in the cup, making the waste liquid discharge more thoroughly and faster. The second isolation tank is connected to the waste liquid pipeline, and the first isolation tank is connected to the pressure sensor. The first isolation tank plays a role in gas-liquid isolation to prevent waste liquid from directly entering the pressure sensor through the pipeline and protects the pressure sensor. Brief Description of the Drawings

[0014] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0015] Figure 1 It is a connection schematic diagram of a detection device for reaction cup blockage and emptying in a hematology analyzer provided by the present invention.

[0016] Figure 2 It is a structural schematic diagram of the first isolation tank.

[0017] Figure 3 It is an assembly schematic diagram of a detection device for reaction cup blockage and emptying in a hematology analyzer provided by the present invention.

[0018] Figure 4 It is a block flow chart of a method for detecting reaction cup blockage and emptying in a hematology analyzer provided by the present invention.

[0019] Figure 5 It is a flow chart of a method for detecting reaction cup blockage and emptying in a hematology analyzer provided by the present invention.

[0020] In the figure: 1 - reaction cup, 2 - pressure sensor, 3 - two - way solenoid valve, 4 - first isolation tank, 5 - second isolation tank, 6 - pump body, 7 - upper interface, 8 - lower interface. Detailed implementation manners

[0021] The embodiments of the present invention will be described in detail below. The examples of the embodiments are shown in the accompanying drawings, where the same or similar reference numerals denote the same or similar elements or elements with the same or similar functions from beginning to end. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to explain the present invention, and should not be construed as a limitation of the present invention.

[0022] Please refer to Figures 1 to 3 , in the first aspect, the present invention provides a detection device for reaction cup blockage and emptying in a hematology analyzer, including a reaction cup 1, a pressure sensor 2, a two - way solenoid valve 3, a first isolation tank 4, a second isolation tank 5 and a pump body 6; the two - way solenoid valve 3 is respectively communicated with the reaction cup 1, the pump body 6 and the second isolation tank 5, and the pressure sensor 2, the first isolation tank 4 and the second isolation tank 5 are connected in sequence.

[0023] In an embodiment of the present invention, the bottom of the reaction cup 1 is connected to one section of the two-way valve 3 through a liquid path pipeline. The pipeline then extends from the other end of the two-way valve 3 and is branched into two paths. One path is connected to the pump body 6, and waste liquid is discharged through the pump body 6. The other path is connected to the second isolation tank 5. The second isolation tank 5 is connected to the first isolation tank 4, and the first isolation tank 4 is connected to the pressure sensor 2. When the blood analyzer performs a sample test, before the sample is added to the reaction cup 1, the pump body 6 is turned on in advance to create a small negative pressure in the first isolation tank 4 and the second isolation tank 5. Then the two-way solenoid valve 3 is opened. After a period of time, assuming 1 second, the pump body 6 is turned off. After waiting for a period of time, assuming 0.5 s, the two-way solenoid valve 3 is turned off. Since the two-way solenoid valve 3 is not immediately turned off when the pump body 6 is turned off, the negative pressure in the second isolation tank 5 will continue to extract the liquid in the reaction cup 1. Assuming the liquid has been drained, at this time, the first isolation tank 4 and the second isolation tank 5 are in direct contact with the atmosphere, and the negative pressure in the first isolation tank 4 and the second isolation tank 5 will be released to the atmospheric pressure. The pressure in the first isolation tank 4 is detected by the pressure sensor 2, which is theoretically the atmospheric pressure. The pressure threshold is defined as relative atmospheric pressure - 5 kPa. If the pressure detected in the first isolation tank 4 is less than - 5 kPa at this time, the reaction cup 1 is slightly blocked or blocked. At this time, the instrument alarms and stops counting. If the pressure in the first isolation tank 4 is greater than - 5 kPa, close to or equal to the atmospheric pressure, it is considered that the instrument is emptied normally. At this time, the sample can be further divided and tested. After the test is completed, an emptying detection of another cup is performed again to ensure the normal operation of the instrument. This device can improve the reliability of the instrument, timely identify when the liquid discharge of the reaction cup 1 is abnormal, stop losses, prevent other fault problems from occurring, save costs, stop the test in time when abnormal, save reagents and reduce the use cost. Before discharging the waste liquid, the pump body 6 is turned on in advance to create a negative pressure in the first isolation tank 4 and the second isolation tank 5 in advance, which improves the efficiency and speed of waste liquid discharge. The first isolation tank 4 and the second isolation tank 5 are small in volume and fast in pressure building time. The negative pressure formed promotes the pumping and discharging of the waste liquid in the cup, making the waste liquid discharge more thoroughly and faster. The second isolation tank 5 is connected to the waste liquid pipeline, and the first isolation tank 4 is connected to the pressure sensor 2. The first isolation tank 4 plays a role in gas-liquid isolation to prevent waste liquid from directly entering the pressure sensor 2 through the pipeline, protecting the pressure sensor 2.

[0024] Further, the first isolation tank 4 has an upper interface 7 and a lower interface 8. The upper interface 7 is located at the top of the first isolation tank 4, and the lower interface 8 is located at the bottom of the first isolation tank 4. The first isolation tank 4 and the second isolation tank 5 have the same structure.

[0025] In the embodiment of the present invention, the lower interface 8 is flush with the bottom of the first isolation tank 4, and the upper interface 7 has a certain distance from the top of the first isolation tank 4. The pipeline is then led out from the other end of the two-way solenoid valve 3 and bifurcated. One path is connected to the pump body 6, and the waste liquid is discharged through the pump body 6. The other path is connected to the lower interface 8 of the second isolation tank 5. The upper interface 7 of the second isolation tank 5 is connected to the lower interface 8 of the first isolation tank 4. The upper interface 7 of the first isolation tank 4 is connected to the pressure sensor 2. The volumes of the first isolation tank 4 and the second isolation tank 5 are 4 ml.

[0026] Please refer to Figures 4 to 5 , secondly, the present invention also provides a method for detecting the blockage and evacuation of reaction cups in a blood analyzer, which is applied to the device for detecting the blockage and evacuation of reaction cups in a blood analyzer as described in the first aspect above, and includes the following steps;

[0027] S1: Turn on the pump body 6 to create a small negative pressure in the first isolation tank 4 and the second isolation tank 5, and detect the negative pressure in the first isolation tank 4 and the second isolation tank 5 through the pressure sensor.

[0028] S2: Open the two-way solenoid valve 3 for 1 second, turn off the pump body 6, wait for 0.5 s, and then turn off the two-way solenoid valve 3. Detect the pressure in the first isolation tank 4 through the pressure sensor 2.

[0029] S3: Compare the pressure value of the first isolation tank 4 with the pressure threshold. If the pressure value of the first isolation tank 4 is less than the pressure threshold, the reaction cup 1 is slightly blocked or blocked. At this time, the instrument alarms and stops counting.

[0030] In the embodiment of the present invention, if it is detected that the pressure in the first isolation tank 4 is less than -5 kPa, the reaction cup 1 is slightly blocked or blocked. At this time, the instrument alarms and stops counting. If the pressure in the first isolation tank 4 is greater than -5 kPa, close to or equal to the atmospheric pressure, it is considered that the evacuation of the instrument is normal. At this time, the sample can be further divided and tested. After the test is completed, the evacuation detection of a cup is carried out again to ensure the normal operation of the instrument.

[0031] The above-disclosed is only a preferred embodiment of a device and method for detecting the blockage and evacuation of reaction cups in a blood analyzer of the present invention. Of course, the scope of the rights of the present invention cannot be limited by this. Those of ordinary skill in the art can understand all or part of the processes of implementing the above embodiments, and the equivalent changes made according to the claims of the present invention still fall within the scope covered by the present invention.

Claims

1. A detection device for clogging and emptying of reaction cups in a blood analyzer, characterized in that it includes a reaction cup, a pressure sensor, a two-way solenoid valve, a first isolation tank, a second isolation tank and a pump body; the two-way solenoid valve is respectively connected to the reaction cup, the pump body and the second isolation tank, and the pressure sensor, the first isolation tank and the second isolation tank are connected in sequence.

2. The detection device for clogging and emptying of reaction cups of a hematology analyzer according to claim 1, It is characterized in that; the first isolation tank has an upper interface and a lower interface, the upper interface is located at the top of the first isolation tank, the lower interface is located at the bottom of the first isolation tank, and the first isolation tank and the second isolation tank have the same structure.

3. The detection device for clogging and emptying of reaction cups in a hematology analyzer according to claim 1, characterized in that ； The volume of the first isolation tank and the second isolation tank is 4 ml.

4. A method for detecting clogging and emptying of reaction cups in a hematology analyzer, applied to the device for detecting clogging and emptying of reaction cups in a hematology analyzer according to any one of claims 1-3, characterized in that, It includes the following steps; Turn on the pump body to create a small negative pressure in the first isolation tank and the second isolation tank, and detect the negative pressure in the first isolation tank and the second isolation tank through the pressure sensor; Open the two-way solenoid valve for 1 second, turn off the pump body, wait for 0.5 s, then close the two-way solenoid valve, and detect the pressure in the first isolation tank through the pressure sensor; Compare the pressure value of the first isolation tank with the pressure threshold. If the pressure value of the first isolation tank is less than the pressure threshold, the reaction cup is slightly clogged or blocked. At this time, the instrument gives an alarm prompt and stops counting.

5. The method for detecting clogging and emptying of reaction cups in a hematology analyzer according to claim 4, characterized in that ； The pressure threshold is defined as relative atmospheric pressure - 5 kPa.

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