Skin care cream with dynamic viscosity regulation and control function and preparation method thereof

Abstract

The invention relates to the technical field of skin care products, and discloses skin care cream with a dynamic viscosity regulation function and a preparation method thereof.The skin care cream comprises a solid grease component, a liquid oil phase component, a hydrophilic phase component and an active ingredient, and the dynamic viscosity regulation function is achieved by optimizing the proportion and combining rheological parameter regulation. And the paste can maintain stable viscosity characteristics at different temperatures and under different shearing conditions. The preparation method comprises the steps of homogeneous phase preparation of an oil phase and a water phase, high-speed emulsification, dynamic viscosity regulation and control, functional component addition and final quality control detection, the rheological property of the paste is calculated through the shearing rate and the temperature, the viscosity is high at the low shearing rate, the skin barrier repair effect is improved, the viscosity is low at the high shearing rate, and the use experience is improved. The method ensures the stability and curative effect of the nursing cream, and is suitable for relieving and nursing skin problems such as psoriasis, atopic dermatitis and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products, and more particularly, to a skin care cream with a dynamic viscosity regulation function and a preparation method thereof. Background Art

[0002] The impairment of the skin barrier function can lead to serious skin problems such as severe dryness, chapping, and stinging, especially prominent in chronic inflammatory skin diseases such as psoriasis and atopic dermatitis. Most of the current skin care creams on the market are mainly for simple moisturizing or repair, and fail to adjust according to the dynamic changes of the skin barrier, making it difficult to adapt to the changes in environmental temperature and humidity and skin conditions. In addition, the rheological properties of traditional skin care creams are relatively fixed, and they may become hard at low temperatures and too thin at high temperatures, thus affecting the use experience and absorption effect. Therefore, it is of great significance to develop a skin care cream with a dynamic viscosity regulation function and ensure the stability and efficacy of the product through a standardized preparation method to improve the practical application value of the skin care cream. Summary of the Invention

[0003] In view of this, the present invention provides a skin care cream with a dynamic viscosity regulation function and a preparation method thereof, aiming to achieve the dynamic viscosity regulation of the skin care cream through specific formulations and preparation processes, enabling it to automatically adjust the viscosity according to environmental changes and different skin conditions, and providing more accurate and efficient skin care effects.

[0004] The present invention provides a preparation method of a skin care cream with a dynamic viscosity regulation function, comprising:

[0005] The raw materials of the skin care cream include a solid oil component, a liquid oil phase component, a hydrophilic phase component, an active ingredient component, and an additive; the solid oil component includes microcrystalline wax, petrolatum, synthetic wax, beeswax, and cetearyl alcohol, the liquid oil phase includes liquid paraffin, evening primrose oil, polydimethylsiloxane, isocetane, lanolin, shea butter, 4-tert-butylcyclohexanol, and cyclopentasiloxane, the hydrophilic phase component includes water, glycerol, 1,2-pentanediol, panthenol, propylparaben, and methylparaben; the active ingredient component includes tocopherol; the additive includes acrylate / carbamate copolymer, PEG-30 dipolyhydroxystearate, aluminum distearate, and magnesium stearate;

[0006] Heat and dissolve the solid oil component in the range of 80 - 90°C, record the melting time Tm and the complete melting temperature Tc; add the liquid oil phase to the dissolved solid oil component, maintain a constant temperature of 85°C, and set the stirring rate Rs between 200 - 500 rpm to make the initial viscosity value η0 within a preset range;

[0007] During the stirring process, the dynamic viscosity η(t) of the system is detected in real time, and the stirring rate Rs is adjusted according to the following formula:

[0008]

[0009] where k1 and k2 represent empirical coefficients; ηt represents the target viscosity;

[0010] When the system temperature drops to 55 - 65 °C, the hydrophilic phase component, active ingredient component and additive are added, and stirring is continued to ensure uniform dispersion;

[0011] The shear viscosities η25 and η40 of the final product are detected at 25 °C and 40 °C respectively, and the stability factor S is calculated:

[0012]

[0013] If S is between 80% - 120%, it is considered that the preparation is successful; the qualified nursing cream is cooled to room temperature, packaged and stored.

[0014] Preferably, the temperature adjustment during the melting process follows the following heat balance equation:

[0015] Q = mC p ΔT;

[0016] where Q represents the heat energy input; m represents the sample mass; Cp represents the specific heat capacity; ΔT represents the temperature change, which is used to determine the melting rate.

[0017] Preferably, during the emulsification and mixing process, the addition rate Vo of the liquid oil phase satisfies the following optimization formula:

[0018]

[0019] where Mo represents the total mass of the liquid phase components; τo represents the optimal addition time to ensure emulsification uniformity.

[0020] Preferably, during the dynamic viscosity regulation process, the real-time change rate of the viscosity satisfies:

[0021]

[0022] where α and β represent viscosity adjustment coefficients, which are used to ensure reasonable adjustment of the stirring rate.

[0023] Preferably, the stability of the emulsification and mixing system is measured by the Zeta potential ζ, and the Zeta potential is calculated as follows:

[0024]

[0025] where η rη represents the relative viscosity; U represents the electrophoretic mobility; ε represents the dielectric constant; the emulsion system is relatively stable when the Zeta potential is above ±30 mV.

[0026] Preferably, during the cooling process, the cooling rate Rc of the system is calculated as follows:

[0027]

[0028] where Tf represents the final cooling temperature; Ti represents the initial temperature; τc represents the cooling time; Rc is controlled between 0.5 - 1.5 °C / min to avoid emulsion breakage.

[0029] Preferably, the calculation of the stability factor S further takes into account the influence of storage time:

[0030] S t = S × e -λt ;

[0031] where St represents the stability factor after storage time t; λ represents the decay coefficient to ensure long-term storage stability.

[0032] Preferably, the dynamic rheological properties of the final product are characterized by the Herschel - Bulkley model:

[0033]

[0034] where τ represents the shear stress; τ0 represents the yield stress; k represents the consistency index; represents the shear rate; n represents the rheological index to evaluate the thixotropy of the nursing cream.

[0035] Preferably, the viscosity of the final product conforms to the following standardized range:

[0036] η final = η0 × f(T, t, p);

[0037] where f(T, t, p) represents the influence function of temperature T, time t, and pressure p, and ηfinal represents the viscosity of the final product, which needs to meet the clinical application standard range to ensure the texture and usage experience of the nursing cream.

[0038] The present invention also provides a skin nursing cream with a dynamic viscosity regulation function, which is prepared according to the preparation method of the skin nursing cream with a dynamic viscosity regulation function described above.

[0039] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0040] By optimizing the compatibility of the oil phase, water phase and active ingredients, and adjusting the dynamic viscosity of the paste by combining the shear rate and temperature changes, the paste can maintain good spreadability and permeability in different environments. Through rheological analysis, it is ensured that the paste maintains a high viscosity at low shear rates to improve film-forming properties, while reducing the viscosity at high shear rates to enhance ductility and improve the comfort of use. The preparation method of the present invention adopts precise emulsification control and parameterized viscosity adjustment to achieve a standardized and quantifiable production process and ensure the stability of the product. In addition, through the study of effector cells for special skin lesions, the formula is optimized to reduce neutrophil-mediated skin discomfort, effectively relieve dryness, chapping and stinging caused by skin diseases such as psoriasis and atopic dermatitis, and improve skin repair ability. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] By reading the following detailed description of the preferred embodiments, various other advantages and benefits will become clear to those of ordinary skill in the art. The drawings are only for the purpose of showing the preferred embodiments and are not considered to be a limitation of the present invention. Moreover, throughout the drawings, the same reference numerals are used to represent the same components. In the drawings:

[0042] Figure 1 It is a schematic flow chart of the preparation method of the skin care paste with dynamic viscosity regulation function of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0043] The exemplary embodiments of the present disclosure will be described in more detail below with reference to the drawings. Although the exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided so that the present disclosure can be more thoroughly understood and the scope of the present disclosure can be fully conveyed to those skilled in the art. It should be noted that, without conflict, the embodiments in the present invention and the features in the embodiments can be combined with each other. The present invention will be described in detail below with reference to the drawings and in combination with the embodiments.

[0044] As Figure 1 shown, this embodiment provides a preparation method of a skin care paste with dynamic viscosity regulation function, including:

[0045] The raw materials of the skin care cream include a solid oil component, a liquid oil phase component, a hydrophilic phase component, an active ingredient component, and an additive; the solid oil component includes microcrystalline wax, petrolatum, synthetic wax, beeswax, and cetearyl alcohol, the liquid oil phase includes liquid paraffin, evening primrose oil, polydimethylsiloxane, isocetane, lanolin, shea butter, 4-tert-butylcyclohexanol, and cyclopentasiloxane, the hydrophilic phase component includes water, glycerol, 1,2-pentanediol, panthenol, propylparaben, and methylparaben; the active ingredient component includes tocopherol; the additive includes acrylate / carbamate copolymer, PEG-30 dipolyhydroxystearate, aluminum distearate, and magnesium stearate;

[0046] Heat and dissolve the solid oil component within the range of 80 - 90 °C, and record the melting time Tm and the complete melting temperature Tc; add the liquid oil phase to the dissolved solid oil component, maintain a constant temperature of 85 °C, and set the stirring rate Rs between 200 - 500 rpm so that the initial viscosity value η0 is within the preset range;

[0047] During the stirring process, continuously detect the dynamic viscosity η(t) of the system, and adjust the stirring rate Rs according to the following formula:

[0048]

[0049] where k1 and k2 represent empirical coefficients; ηt represents the target viscosity;

[0050] When the system temperature drops to 55 - 65 °C, add the hydrophilic phase component, the active ingredient component, and the additive, and continue stirring to ensure uniform dispersion;

[0051] Detect the shear viscosities η25 and η40 of the final product at 25 °C and 40 °C respectively, and calculate the stability factor S:

[0052]

[0053] If S is between 80% - 120%, it is considered that the preparation is successful; cool the qualified skin care cream to room temperature, package it, and store it.

[0054] It can be seen that the preparation method in this embodiment is realized based on specific raw material ratios and process steps, and each step is carefully designed to ensure the performance and quality of the final product. Among them, the heating and dissolution of the solid oil component is the basis of the preparation process, which provides a stable matrix for subsequent mixing and emulsification. The addition of the liquid oil phase further enriches the texture of the cream, and also helps to improve the moisturizing performance and skin permeability of the product.

[0055] During the stirring process, by detecting the dynamic viscosity of the system in real time and adjusting the stirring rate, the rheological properties of the paste can be precisely controlled, thus meeting different usage requirements. This step not only reflects the flexibility of the preparation method but also ensures the stability and uniformity of the final product.

[0056] When the temperature drops to an appropriate range, hydrophilic phase components, active ingredient components, and additives are added. These components can endow the skin care paste with various skin care effects, such as moisturizing, antioxidant, soothing, etc. Continuing to stir to ensure the uniform dispersion of these components in the system is the key to obtaining a high-quality product.

[0057] Finally, by detecting the shear viscosity of the final product at different temperatures and calculating the stability factor, the stability and applicability of the product can be evaluated. Only the skin care paste that meets specific standards can be considered successfully prepared and then undergo subsequent cooling, packaging, and storage.

[0058] It can be understood that the preparation method of this embodiment is based on an in-depth understanding and precise control of the raw material characteristics, aiming to provide a skin care paste with dynamic viscosity regulation function. Through the carefully designed preparation steps, it is ensured that the final product not only has excellent texture and stability but also can meet the needs of different skin types and usage environments. In addition, this method also fully considers the safety and effectiveness of the raw materials, providing consumers with a trustworthy skin care option. In practical applications, this preparation method can be adjusted and optimized according to specific needs to meet the requirements of different markets and consumers.

[0059] In some embodiments of the present application, the adjustment of the temperature during the melting process follows the following heat balance equation:

[0060] Q = mC p ΔT;

[0061] Wherein, Q represents the heat energy input; m represents the sample mass; Cp represents the specific heat capacity; ΔT represents the temperature change amount, which is used to determine the melting rate.

[0062] It is understandable that in the preparation method of this embodiment, during the melting process, not only the influence of temperature on the melting state of raw materials is considered, but also the heat energy input is precisely controlled through the heat balance equation to ensure the stability and controllability of the melting rate. The addition of this step further improves the accuracy and scientific nature of the preparation method, providing a strong guarantee for the performance and quality of the final product. At the same time, this preparation method also fully considers the interaction and compatibility between raw materials, ensuring the rationality and effectiveness of each step. In actual operation, operators need to strictly follow the preparation steps to ensure the stability and uniformity of the final product. In addition, this preparation method can also be adjusted and optimized according to specific requirements, such as adjusting the raw material ratio, changing parameters such as stirring rate or temperature, to meet the needs of different markets and consumers. Generally speaking, this embodiment provides a skin care cream with dynamic viscosity regulation function and its preparation method. This method is based on specific raw material ratios and process steps, and by precisely controlling the conditions and parameters of each step, it ensures the performance and quality of the final product. At the same time, this method also fully considers the safety and effectiveness of raw materials, providing consumers with a trustworthy skin care option.

[0063] In some embodiments of the present application, during the emulsification mixing process, the addition rate Vo of the liquid oil phase satisfies the following optimization formula:

[0064]

[0065] Where Mo represents the total mass of the liquid phase components; τo represents the optimal addition time to ensure emulsification uniformity.

[0066] It is understandable that in the preparation method of this embodiment, the addition rate of the liquid oil phase is precisely controlled during the emulsification mixing process. By introducing the optimization formula to determine the optimal addition rate, the uniformity during the emulsification process can be ensured, thereby improving the texture and stability of the final product. The addition of this step not only reflects the refinement and scientific nature of the preparation method, but also further guarantees the product quality and user experience.

[0067] In addition, this preparation method also fully considers various problems that may occur during the emulsification process, such as oil-water separation and uneven emulsification, and takes corresponding measures for prevention and solution. For example, by precisely controlling parameters such as stirring rate and temperature, the occurrence of oil-water separation can be effectively avoided; at the same time, by selecting appropriate emulsifiers and stabilizers, the stability and uniformity of the emulsification system can be further improved.

[0068] In actual operation, the operator needs to strictly follow the preparation steps and closely monitor the conditions and parameters of each step. If any abnormal situation or deviation from the expected results is found, the operation should be stopped immediately and inspected and analyzed. Only by ensuring that each step meets the preset standards and requirements can a high-quality skin care cream product be obtained.

[0069] Generally speaking, the skin care cream with dynamic viscosity regulation function and its preparation method provided by this embodiment not only have excellent texture and stability, but also can meet the needs of different skin types and usage environments. At the same time, this method also fully considers the safety and effectiveness of raw materials, as well as various factors and details in the preparation process, providing consumers with a trustworthy skin care option. In the future, with the continuous improvement and diversification of people's skin care needs, this preparation method can also be adjusted and optimized according to specific requirements to meet the needs of different markets and consumers.

[0070] In some embodiments of the present application, during the dynamic viscosity regulation process, the real-time change rate of the viscosity satisfies:

[0071]

[0072] where α and β represent viscosity adjustment coefficients, which are used to ensure reasonable adjustment of the stirring rate.

[0073] It can be understood that in the preparation method of this embodiment, during the dynamic viscosity regulation process, by precisely controlling the real-time change rate of the viscosity, the rheological properties of the paste are further ensured to meet the preset requirements. By introducing the viscosity adjustment coefficients α and β, reasonable adjustment of the stirring rate can be achieved, thus ensuring the stability and uniformity of the paste while ensuring the emulsification uniformity. The addition of this step not only improves the flexibility and scientific nature of the preparation method, but also provides a strong guarantee for the performance and quality of the final product.

[0074] In actual operation, the operator needs to closely monitor the real-time change rate of the viscosity and make timely adjustments according to the preset viscosity adjustment coefficients. At the same time, it is also necessary to pay attention to the coordinated control of parameters such as the stirring rate and temperature to ensure the stability and controllability of the entire preparation process. If any abnormal situation or deviation from the expected results is found, the operation should be stopped immediately and inspected and analyzed to avoid adverse effects on the performance and quality of the final product.

[0075] In addition, the preparation method of this embodiment also fully considers the interactions and compatibility between raw materials, as well as various factors and details during the preparation process. Through carefully designed preparation steps and precise control of the conditions and parameters of each step, it is ensured that the final product not only has excellent texture and stability, but also can meet the needs of different skin types and usage environments. At the same time, this method also fully considers the safety and effectiveness of raw materials, providing consumers with a trustworthy skin care option.

[0076] In summary, the skin care cream with dynamic viscosity regulation function and its preparation method provided by this embodiment not only have scientific nature and precision, but also fully consider the safety and effectiveness of raw materials, as well as various factors and details during the preparation process. This method can provide consumers with a trustworthy skin care option and is expected to be adjusted and optimized according to specific needs in the future to meet the needs of different markets and consumers.

[0077] In some embodiments of the present application, the stability of the emulsifying mixing system is measured by the Zeta potential ζ, and the Zeta potential is calculated as follows:

[0078]

[0079] where η r represents the relative viscosity; U represents the electrophoretic mobility; ε represents the dielectric constant; the emulsifying system is relatively stable when the Zeta potential range is above ±30 mV.

[0080] It can be understood that when evaluating the stability of the emulsifying mixing system in the preparation method of this embodiment, the Zeta potential ζ is introduced as a key index. By accurately calculating the Zeta potential, the stability of the emulsifying system can be judged, thereby ensuring the performance and quality of the final product. When the Zeta potential range is above ±30 mV, the emulsifying system is considered relatively stable, which helps to obtain a skin care cream product with uniform texture and good stability.

[0081] In actual operation, the operator needs to accurately measure the Zeta potential of the emulsifying system using professional measuring equipment and evaluate the stability of the system according to the measurement results. If it is found that the Zeta potential is lower than the preset range, measures should be taken immediately for adjustment, such as increasing the dosage of emulsifier, changing the stirring conditions, etc., to improve the stability of the emulsifying system.

[0082] In addition, the preparation method of this embodiment also fully considers the interaction and compatibility between raw materials, as well as various factors and details in the preparation process. Through carefully designed preparation steps and precise control of the conditions and parameters of each step, it is ensured that the final product not only has excellent texture and stability, but also can meet the needs of different skin types and usage environments. At the same time, this method also fully considers the safety and effectiveness of raw materials, providing consumers with a trustworthy skin care option.

[0083] In summary, the skin care cream with dynamic viscosity regulation function and its preparation method provided by this embodiment not only have scientificity and precision, but also fully consider the safety and effectiveness of raw materials, as well as various factors and details in the preparation process. This method realizes the precise regulation of the rheological properties of the paste by precisely controlling the raw material ratio, process steps and parameter settings, thus obtaining a product with uniform texture, good stability and remarkable skin care effect.

[0084] In some embodiments of the present application, during the cooling process, the cooling rate Rc of the system is calculated as follows:

[0085]

[0086] where, Tf represents the final cooling temperature; Ti represents the initial temperature; τc represents the cooling time; Rc is controlled between 0.5 - 1.5 °C / min to avoid emulsion breakage.

[0087] It can be understood that in the preparation method of this embodiment, the cooling rate of the system is strictly controlled during the cooling process. By precisely calculating the cooling rate Rc and controlling it within the range of 0.5 - 1.5 °C / min, adverse situations such as emulsion breakage can be effectively avoided, thus ensuring the texture and stability of the final product. The addition of this step further improves the scientificity and precision of the preparation method.

[0088] In actual operation, the operator needs to closely monitor the temperature change of the system and make timely adjustments according to the preset cooling rate. At the same time, other parameters during the cooling process, such as stirring rate, environmental humidity, etc., also need to be noted to ensure the stability and controllability of the entire cooling process. If any abnormal situation or result deviating from the expectation is found, the operation should be stopped immediately for inspection and analysis to avoid adverse effects on the performance and quality of the final product.

[0089] In addition, during the cooling process of the preparation method of this embodiment, the interactions and compatibility between raw materials, as well as various factors and details during the cooling process, are fully considered. Through the carefully designed cooling steps and precise control of the conditions and parameters of each step, it is ensured that the final product not only has excellent texture and stability but also can meet the needs of different skin types and usage environments. At the same time, this method also fully considers the safety and effectiveness of raw materials, providing consumers with a trustworthy skin care option.

[0090] In summary, the skin care cream with dynamic viscosity regulation function and its preparation method provided by this embodiment also demonstrate a high degree of scientificity and precision during the cooling process. By strictly controlling the cooling rate and other related parameters, this method ensures that the final product has a uniform texture, good stability, and excellent skin care efficacy.

[0091] In some embodiments of the present application, the calculation of the stability factor S further incorporates the influence of storage time:

[0092] S t = S × e -λt ;

[0093] where St represents the stability factor after storage time t; λ represents the attenuation coefficient to ensure long-term storage stability.

[0094] It can be understood that when evaluating the long-term storage stability of the preparation method of this embodiment, the stability factor S is introduced as a key indicator, and the influence of storage time is further considered. By accurately calculating the stability factor S and combining it with the attenuation coefficient λ, the stability of the skin care cream during long-term storage can be comprehensively evaluated. The addition of this step not only improves the evaluation accuracy of product stability but also provides strong support for ensuring the long-term quality of the final product.

[0095] In actual operation, the operator needs to regularly take samples and measure the stability factor S after different storage times. By comparing the S values at different storage times and combining them with the attenuation coefficient λ, the trend of stability change of the product during long-term storage can be judged. If it is found that the S value significantly decreases or deviates from the expected range, measures should be immediately taken for improvement, such as adjusting the formula, optimizing the preparation process, etc., to improve the long-term storage stability of the product.

[0096] In addition, the preparation method of this embodiment also fully considers the interaction and compatibility between raw materials, as well as various factors and details during the preparation and storage processes. Through carefully designed preparation steps, precise control of the conditions and parameters of each step, and scientific long-term stability evaluation methods, it is ensured that the final product not only has excellent texture and stability but also can meet the needs of different skin types and usage environments. At the same time, this method also fully considers the safety and effectiveness of raw materials, providing consumers with a trustworthy skin care option that can maintain excellent performance for a long time.

[0097] In some embodiments of the present application, the dynamic rheological properties of the final product are characterized by the Herschel-Bulkley model:

[0098]

[0099] where τ represents the shear stress; τ0 represents the yield stress; k represents the consistency index; represents the shear rate; n represents the rheological index to evaluate the thixotropy of the nursing cream.

[0100] It can be understood that when evaluating the dynamic rheological properties of the final product, the preparation method of this embodiment uses the Herschel-Bulkley model for characterization. This is a widely recognized method that can accurately describe the rheological behavior of materials, especially for skin care cream products with yield stress and non-Newtonian fluid characteristics. By precisely measuring the shear stress τ, yield stress τ0, consistency index k, shear rate, and rheological index n, the thixotropy of the nursing cream, that is, its flow and deformation characteristics under the action of force, can be comprehensively evaluated.

[0101] In actual operation, the operator needs to use a professional rheometer to test the dynamic rheological properties of the final product. By setting different shear rates, measuring the corresponding shear stresses, and calculating in combination with the Herschel-Bulkley model, a series of key rheological parameters can be obtained. These parameters not only reflect the texture and fluidity of the nursing cream but also are closely related to its touch and effect in actual use.

[0102] In addition, the preparation method of this embodiment also fully considers the interaction and compatibility between raw materials, as well as various factors and details during the preparation process. Through carefully designed preparation steps and precise control of the conditions and parameters of each step, it is ensured that the final product not only has excellent dynamic rheological properties but also can meet the needs of different skin types and usage environments. At the same time, this method also fully considers the safety and effectiveness of raw materials, providing consumers with a trustworthy skin care option with excellent performance.

[0103] In summary, the skin care cream with dynamic viscosity regulation function and its preparation method provided in this embodiment also demonstrate high scientificity and accuracy in the evaluation and characterization of dynamic rheological properties. By using the Herschel-Bulkley model for characterization and combining professional rheological testing techniques, this method can accurately evaluate the thixotropy of the care cream, providing consumers with a product with uniform texture, good fluidity, comfortable touch and significant skin care effects.

[0104] In some embodiments of the present application, the viscosity of the final product meets the following standardized range:

[0105] η final = η0 × f(T, t, p);

[0106] wherein, f(T, t, p) represents the influence function of temperature T, time t and pressure p, and ηfinal represents that the viscosity of the final product meets the clinical application standard range to ensure the texture and use experience of the care cream.

[0107] Among them,

[0108] In the temperature influence term T0 is the standard temperature (such as room temperature 25°C). α is the temperature sensitivity coefficient, usually positive, indicating the trend of viscosity decrease with increasing temperature (negative exponential relationship). This term shows that as the temperature increases, the viscosity index decays, conforming to the physical law of viscosity decrease at high temperatures in rheology.

[0109] In the time influence term (1 + βt), β is the time influence coefficient, characterizing the influence of storage time on viscosity. When the time t increases, the viscosity may increase due to oxidation, solvent evaporation or polymerization reaction (increasing trend). This term conforms to the trend that the skin care cream may thicken during storage.

[0110] In the pressure influence term (1 + γp), γ is the pressure influence coefficient, usually positively correlated, characterizing the gain influence of pressure on viscosity.

[0111] At higher pressures, the molecular spacing of the material decreases, and the rheological properties may change, thereby affecting the viscosity.

[0112] It can be understood that when controlling the viscosity of the final product in the preparation method of this embodiment, the influences of various factors such as temperature T, time t and pressure p are fully considered. These factors may have important impacts on the viscosity of the product during preparation and storage, and thus affect its texture and use experience. By introducing the influence function f(T, t, p) and combining the clinical application standard range, the viscosity of the final product can be accurately controlled to ensure that the care cream has an appropriate texture and can meet the usage requirements of consumers.

[0113] In actual operation, the operator needs to strictly control conditions such as temperature, time, and pressure during the preparation process to ensure the accuracy of the influence function f(T, t, p). At the same time, it is also necessary to regularly conduct viscosity tests on the final product to verify whether it meets the clinical application standard range. If it is found that the viscosity deviates from the expected range, measures should be taken immediately for adjustment, such as optimizing the preparation process, adjusting the raw material ratio, etc., to improve the quality and stability of the product.

[0114] In addition, the preparation method of this embodiment also fully considers the interaction and compatibility between raw materials, as well as various factors and details during the preparation process. Through carefully designed preparation steps and precise control of the conditions and parameters of each step, it is ensured that the final product not only has an appropriate viscosity but also has good stability and safety. These advantages make the skin care cream provided by this embodiment a trustworthy and excellent-performing choice that can meet the needs of different skin types and usage environments.

[0115] In summary, the skin care cream with dynamic viscosity regulation function and its preparation method provided by this embodiment also show a high degree of scientificity and precision in viscosity control. By introducing the influence function f(T, t, p) and combining it with the clinical application standard range, this method can precisely control the viscosity of the final product, providing consumers with a product with an appropriate texture, good user experience, and significant skin care effects.

[0116] Those skilled in the art should understand that the embodiments of the present application can be provided as methods, systems, or computer program products. Therefore, the present application can take the form of a complete hardware embodiment, a complete software embodiment, or an embodiment combining software and hardware aspects. Moreover, the present application can take the form of a computer program product implemented on one or more computer-usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) containing computer-usable program code.

[0117] The present application is described with reference to the flowcharts and / or block diagrams of methods, devices (systems), and computer program products according to the embodiments of the present application. It should be understood that each flow and / or block in the flowchart and / or block diagram can be implemented by computer program instructions, and the combination of the flows and / or blocks in the flowchart and / or block diagram can also be implemented by computer program instructions. These computer program instructions can be provided to the processor of a general-purpose computer, a special-purpose computer, an embedded processor, or other programmable data processing devices to generate a machine, so that the instructions executed by the processor of the computer or other programmable data processing devices generate means for implementing the functions specified in one Figure 1 one flow or multiple flows and / or blocks Figure 1 one block or multiple blocks.

[0118] These computer program instructions can also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to work in a particular manner, such that the instructions stored in the computer-readable memory produce a manufacture including an instruction device that implements the functions specified in one or more of the processes and / or blocks Figure 1 in one or more of the processes and / or blocks Figure 1 specified in the function.

[0119] These computer program instructions can also be loaded onto a computer or other programmable data processing apparatus, such that a series of operation steps are performed on the computer or other programmable apparatus to produce a computer-implemented process, so that the instructions executed on the computer or other programmable apparatus provide steps for implementing the functions specified in one or more of the processes and / or blocks Figure 1 in one or more of the processes and / or blocks Figure 1 specified in the function.

[0120] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit them. Although the present invention has been described in detail with reference to the above embodiments, those of ordinary skill in the art should understand that: the specific implementation manners of the present invention can still be modified or equivalently replaced, and any modification or equivalent replacement without departing from the spirit and scope of the present invention shall be covered by the protection scope of the claims of the present invention.

Claims

1. A preparation method of a skin care cream with a dynamic viscosity regulation function, characterized in that, Comprising: The raw materials of the skin care cream include a solid oil component, a liquid oil phase component, a hydrophilic phase component, an active ingredient component, and an additive; the solid oil component includes microcrystalline wax, petrolatum, synthetic wax, beeswax, and cetearyl alcohol, the liquid oil phase includes liquid paraffin, evening primrose oil, polydimethylsiloxane, isocetane, lanolin, shea butter, 4-tert-butylcyclohexanol, and cyclopentasiloxane, the hydrophilic phase component includes water, glycerin, 1,2-pentanediol, panthenol, propylparaben, and methylparaben; the active ingredient component includes tocopherol; the additive includes acrylate / carbamate copolymer, PEG-30 dipolyhydroxystearate, aluminum distearate, and magnesium stearate; Heat and dissolve the solid oil component within the range of 80 - 90 °C, record the melting time Tm and the complete melting temperature Tc; add the liquid oil phase to the dissolved solid oil component, maintain a constant temperature of 85 °C, and set the stirring rate Rs between 200 - 500 rpm, so that the initial viscosity value η0 is within the preset range; During the stirring process, real-time detect the dynamic viscosity η(t) of the system, and adjust the stirring rate Rs according to the following formula: where k1 and k2 represent empirical coefficients; ηt represents the target viscosity; When the system temperature drops to 55 - 65 °C, add the hydrophilic phase component, the active ingredient component, and the additive, and continue stirring to ensure uniform dispersion; Respectively detect the shear viscosities η25 and η40 of the final product at 25 °C and 40 °C, and calculate the stability factor S: If S is between 80% - 120%, it is considered that the preparation is successful; cool the qualified skin care cream to room temperature, package it, and store it.

2. The preparation method of the skin care cream with dynamic viscosity regulation function according to claim 1, characterized in that, The adjustment of the temperature during the melting process follows the following heat balance equation: Q = mC p ΔT; where Q represents the heat energy input; m represents the sample mass; Cp represents the specific heat capacity; ΔT represents the temperature change amount, which is used to determine the melting rate.

3. The preparation method of the skin care cream with dynamic viscosity regulation function according to claim 1, characterized in that, During the emulsification and mixing process, the addition rate Vo of the liquid oil phase satisfies the following optimization formula: where Mo represents the total mass of the liquid phase component; τo represents the optimal addition time to ensure emulsification uniformity.

4. The preparation method of the skin care cream with dynamic viscosity regulation function according to claim 1, characterized in that, During the dynamic viscosity regulation process, the real-time change rate of the viscosity satisfies: where α and β represent viscosity adjustment coefficients, which are used to ensure reasonable adjustment of the stirring rate.

5. The preparation method of the skin care cream with the function of dynamically regulating viscosity according to claim 1, characterized in that, The stability of the emulsification mixing system is measured by the Zeta potential ζ, and the Zeta potential is calculated as follows: Among them, η r represents the relative viscosity; U represents the electrophoretic mobility; ε represents the dielectric constant; the emulsion system is relatively stable when the Zeta potential ranges above ±30 mV.

6. The preparation method of the skin care cream with the function of dynamically regulating viscosity according to claim 1, characterized in that, During the cooling process, the cooling rate Rc of the system is calculated as follows: where Tf represents the final cooling temperature; Ti represents the initial temperature; τc represents the cooling time; Rc is controlled between 0.5 - 1.5 °C / min to avoid emulsion breakage.

7. The preparation method of the skin care cream with dynamic viscosity regulation function according to claim 1, characterized in that, The calculation of the stability factor S further introduces the influence of storage time: S t = S × e -λt ; where St represents the stability factor after storage time t; λ represents the attenuation coefficient to ensure long-term storage stability.

8. The preparation method of the skin care cream with dynamic viscosity regulation function according to claim 1, characterized in that, The dynamic rheological properties of the final product are characterized by the Herschel-Bulkley model: Among them, τ represents shear stress; τ0 represents yield stress; k represents consistency index; represents shear rate; n represents rheological index to evaluate the thixotropy of the nursing cream.

9. The preparation method of the skin care cream with the function of dynamically regulating viscosity according to claim 1, characterized in that, The viscosity of the final product conforms to the following standardized range: η final = η0 × f(T, t, p); Among them, f(T, t, p) represents the influence function of temperature T, time t, and pressure p, and ηfinal represents the viscosity compliance of the final product, which needs to meet the standard range of clinical application to ensure the texture and usage experience of the nursing cream.

10. A skin care cream with a dynamic viscosity regulation function, characterized in that, It is obtained by preparing the skin care cream with dynamic viscosity regulation function according to any one of claims 1-9.

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