Gel for repairing sensitive skin

Abstract

The invention discloses a gel for repairing sensitive skin, which comprises 0.2% of purslane extract, 0.5% of pseudo-ginseng extract, 0.5% of hamamelis virginiana extract, 0.5% of chamomile extract, 0.1% of cortex dictamni extract, 0.5% of cacumen biotae extract, 0.5% of acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer and purified water, and the pH value of the final product is about 6.5. By utilizing the synergistic effect of various natural plant extracts, the sensitive skin is comprehensively repaired from multiple aspects such as anti-inflammation, antibiosis, antioxidation, immunoregulation and skin barrier repair, 50 cases are clinically observed, the effective rate reaches 70%, and the traditional Chinese medicine composition is remarkably superior to similar products. Natural plant extracts are adopted, chemical components prone to allergy are not added, irritation is small, the allergy phenomenon does not occur through clinical observation at present, and the mask is suitable for being used by various people with sensitive skin. The gel is fresh and cool in texture and good in air permeability, compared with a traditional cream product, after the cream is smeared, the skin does not feel thick, the use experience is better, and the compliance of a patient is improved.

Description

Technical Field

[0001] The present invention relates to the technical fields of dermatosis treatment and medical cosmetology, and particularly relates to a gel for repairing sensitive skin. Background Art

[0002] Sensitive skin is a skin state with impaired skin barrier function and overreaction to external stimuli. Common symptoms include skin redness, itching, stinging, etc. In the fields of dermatosis treatment and medical cosmetology, the repair of sensitive skin has always been a research focus.

[0003] Currently, there are a wide variety of products on the market for repairing sensitive skin, but there are generally many problems. Most products are in the form of creams, with poor air permeability, a heavy feeling on the skin after application, and poor comfort. In terms of repair effects, there are significant differences among different products. Some products contain only a single active ingredient, but it is difficult to play a comprehensive repair role for various problems of sensitive skin, resulting in an unsatisfactory overall repair effect. For example, some products only focus on anti-inflammatory effects, but ignore the functions of antibacterial and skin barrier repair, and cannot fundamentally improve the state of sensitive skin.

[0004] In addition, the chemical components added in many products are prone to cause allergic reactions, further increasing the skin burden. Especially some synthetic preservatives, fragrances, etc. have a higher risk of allergy when used on sensitive skin, which makes consumers have many concerns when choosing repair products. Therefore, in view of the above deficiencies, the present invention proposes a gel for repairing sensitive skin. Summary of the Invention

[0005] The purpose of the present invention is to solve at least one of the technical problems existing in the prior art, and provide a gel for repairing sensitive skin. By using the synergistic effect of a variety of natural plant extracts, it comprehensively repairs sensitive skin from multiple aspects such as anti-inflammatory, antibacterial, antioxidant, immune regulation, and skin barrier repair. After 50 cases of clinical observation, the effective rate reaches 70%, which is significantly better than similar products. Using natural plant extracts, without adding easily allergic chemical components, it has little irritation. Currently, no allergic phenomena have been observed in clinical observations, and it is suitable for various sensitive skin populations. The gel has a fresh texture and good air permeability. Compared with traditional cream products, there is no heavy feeling on the skin after application, and the use experience is better, improving the compliance of patients.

[0006] The present invention also provides the above-mentioned gel for repairing sensitive skin, and the gel formula includes: purslane extract 0.2%, notoginseng extract 0.5%, witch hazel extract 0.5%, chamomile extract 0.5%, cortex dictamni radicis extract 0.1%, biota orientalis extract 0.5%, acrylate / C10-30 alkyl acrylate cross-linked polymer 0.5%, and purified water. The final finished product has a pH value of about 6.5;

[0007] The manufacturing process of the gel includes the following steps:

[0008] Step 1: Add water, propylene glycol, glycerin, hexylene glycol, hydroxyacetophenone, acrylate / C10-30 alkyl acrylate cross-linked polymer, and disodium EDTA into the water phase pot, heat to 70°C - 75°C, and stir until dissolved evenly.

[0009] Step 2: Pump the materials in the water phase pot into the main pot, and stir to cool down to below 40°C.

[0010] Step 3: Add the witch hazel water, chamomile extract, oriental arborvitae leaf extract, purslane extract, cortex dictamni extract, and notoginseng extract that have been dissolved evenly in advance into the main pot in sequence, and stir until dissolved evenly.

[0011] Step 4: Filter and discharge the materials, and conduct semi-finished product inspection.

[0012] Step 5: Fill and package, and store in the warehouse after passing the finished product inspection.

[0013] For a gel for sensitive skin repair provided by the present invention, the flavonoids in the purslane extract have antioxidant and anti-inflammatory activities, can inhibit the production and release of inflammatory cytokines, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), and inhibit the synthesis of inflammatory mediators histamine and prostaglandin; the alkaloids in the purslane extract have antibacterial effects and have inhibitory effects on various bacteria and fungi such as Staphylococcus aureus, Escherichia coli, and Candida albicans; the polysaccharides in the purslane extract participate in immune regulation, can regulate the body's immune function, and enhance skin immunity.

[0014] For a gel for sensitive skin repair provided by the present invention, the notoginsenosides in the notoginseng extract have anti-inflammatory effects and can inhibit the release of inflammatory cytokines; the notoginseng extract also has antibacterial activity and can inhibit the growth of bacteria such as Propionibacterium acnes; at the same time, the notoginseng extract can inhibit the excessive differentiation of sebaceous gland cells, reduce sebum secretion, and can also accelerate the proliferation of epidermal cells, reducing erythema and scar formation after skin injury.

[0015] For a gel for sensitive skin repair provided by the present invention, the witch hazel extract is rich in antioxidant components, can scavenge free radicals in the body, reduce the damage of oxidative stress to skin cells; at the same time, it has certain anti-inflammatory characteristics and can relieve skin inflammatory reactions.

[0016] For a gel for sensitive skin repair provided by the present invention, the chamomile extract has anti-inflammatory and soothing effects, can reduce skin inflammatory reactions, relieve symptoms such as skin redness, swelling, itching and discomfort; it also has certain antioxidant ability, which helps to protect skin cells from free radical damage.

[0017] A gel for sensitive skin repair provided by the present invention, the cortex dictamni extract has antibacterial and anti-inflammatory effects, can inhibit a variety of bacteria and fungi, reduce skin inflammation, and promote skin repair.

[0018] A gel for sensitive skin repair provided by the present invention, the platycladus orientalis leaf extract has antibacterial, anti-inflammatory and antioxidant properties, can inhibit the growth of bacteria and fungi, reduce the inflammatory response, scavenge free radicals, and protect skin cells.

[0019] A gel for sensitive skin repair provided by the present invention, the acrylate / C10-30 alkyl acrylate cross-linked polymer is used to adjust the texture and stability of the gel, so that the gel has appropriate consistency and morphology, which is convenient for spreading and use.

[0020] Compared with the prior art, a gel for sensitive skin repair of the present invention uses the synergistic effect of a variety of natural plant extracts to comprehensively repair sensitive skin from multiple aspects such as anti-inflammatory, antibacterial, antioxidant, immune regulation and skin barrier repair. The effective rate of 50 cases in clinical observation reaches 70%, which is significantly better than similar products. Natural plant extracts are used, and no easily allergic chemical components are added, with little irritation. At present, no allergic phenomena are found in clinical observation, and it is suitable for various sensitive skin populations. The gel has a fresh texture and good air permeability. Compared with traditional cream products, there is no heavy feeling on the skin after application, and the use experience is better, improving the compliance of patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The present invention will be further described below in conjunction with the drawings and embodiments;

[0022] Figure 1 It is a schematic diagram of the overall process of a gel for sensitive skin repair of the present invention;

[0023] Figure 2 It is a schematic diagram of the production process of Embodiment 1 of the present invention;

[0024] Figure 3 It is a schematic diagram of the production process of Embodiment 2 of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0025] This part will describe the specific embodiments of the present invention in detail. The preferred embodiments of the present invention are shown in the drawings. The function of the drawings is to supplement the description of the text part of the specification, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the present invention, but it cannot be understood as a limitation on the protection scope of the present invention.

[0026] Example 1, refer to Figure 1 、 2, an embodiment of the present invention provides a gel for sensitive skin repair, which comprises the following steps:

[0027] Step 1, raw material preparation: accurately weigh 0.2 g of purslane extract, 0.5 g of notoginseng extract, 0.5 g of witch hazel extract, 0.5 g of chamomile extract, 0.1 g of dictamnus root bark extract, 0.5 g of biota orientalis leaf extract, and 0.5 g of acrylate / C10-30 alkanol acrylate cross-linked polymer. Prepare 80 g of water, 5 g of propylene glycol, 3 g of glycerol, 2 g of hexylene glycol, 0.5 g of p-hydroxyacetophenone, and 0.1 g of disodium EDTA. All raw materials must ensure qualified quality and reliable sources. During the weighing process, use an electronic balance with a precision of 0.01 g to ensure accurate weighing.

[0028] Step 2, aqueous phase preparation: Add water, propylene glycol, glycerol, hexylene glycol, p-hydroxyacetophenone, acrylate / C10-30 alkanol acrylate cross-linked polymer, and disodium EDTA into a clean aqueous phase pot. Turn on the stirring device and stir at a speed of 200 r / min for 5 minutes to preliminarily mix the components. Then heat the aqueous phase pot to 72 °C, maintain this temperature and continue stirring for 30 minutes until all components are completely dissolved to form a uniform aqueous phase system. During the heating and stirring process, closely observe the state of the solution to ensure that there are no lumps or undissolved substances.

[0029] Step 3, mixing and adding: Slowly pump the liquid in the aqueous phase pot into the main pot through a pipeline, turn on the stirring device of the main pot, and set the stirring speed to 150 r / min to allow the liquid to cool naturally to below 40 °C. During the cooling process, dissolve the witch hazel extract, chamomile extract, biota orientalis leaf extract, purslane extract, dictamnus root bark extract, and notoginseng extract evenly with an appropriate amount of propylene glycol. When the temperature in the main pot drops below 40 °C, slowly add these dissolved extracts in the above order one by one. Stir for 5 minutes after each addition to ensure that all components are evenly dispersed. After all additions are completed, continue stirring for 20 minutes.

[0030] Step 4, filtering, discharging and inspection: Filter the mixed gel using a 100-mesh filter screen to remove possible impurities. Conduct a comprehensive inspection on the filtered semi-finished product, including checking its color, transparency, and uniformity in appearance, pH value detection using pH test paper or a pH meter to ensure that the pH value is between 6.3 and 6.7, and microbial limit detection to detect the number of microorganisms such as bacteria, molds, and yeasts according to relevant hygiene standards. If any of the indicators is unqualified, adjust or remanufacture the semi-finished product.

[0031] Step 5: Filling, Packaging, and Final Product Inspection: Fill the qualified semi-finished products into sterile plastic hoses at a specification of 10 g / each. Ensure accurate dosage and no leakage during the filling process. After filling, perform outer packaging, affix product labels, and indicate information such as product name, ingredients, usage method, and shelf life. Conduct a second random inspection of the final products with a sampling ratio of 10%. The inspection items include appearance. Check for liquid leakage by squeezing the hoses for seal integrity. For stability, place the final products in an environment of 40 °C for 7 days and observe for any phenomena of layering, color change, or taste change. After passing the random inspection, store the final products in the warehouse.

[0032] Example 2, referring to Figure 1 、 3 , a gel for sensitive skin repair according to an embodiment of the present invention, which comprises the following steps:

[0033] Step 1: Raw Material Preparation: Accurately weigh 0.2 g of purslane extract, 0.5 g of notoginseng extract, 0.5 g of witch hazel extract, 0.5 g of chamomile extract, 0.1 g of cortex dictamni root extract, 0.5 g of biota orientalis leaf extract, and 0.5 g of acrylate / C10-30 alkyl acrylate cross-linked polymer. Prepare 75 g of water, 6 g of propylene glycol, 4 g of glycerol, 2.5 g of hexylene glycol, 0.6 g of p-hydroxyacetophenone, and 0.15 g of disodium EDTA. The raw material weighing operation is the same as in Example 1 to ensure accuracy.

[0034] Step 2: Aqueous Phase Preparation: Add water, propylene glycol, glycerol, hexylene glycol, p-hydroxyacetophenone, acrylate / C10-30 alkyl acrylate cross-linked polymer, and disodium EDTA to the aqueous phase pot. First, stir at a speed of 250 r / min for 8 minutes to initially mix the components evenly, then heat to 73 °C and continue stirring for 35 minutes to fully dissolve and mix the aqueous phase components evenly. During this process, pay attention to controlling the heating rate and stirring intensity to prevent uneven heating of the components or excessive stirring to generate bubbles.

[0035] Step 3: Mixing and Addition: Pump the aqueous phase liquid into the main pot, adjust the stirring speed of the main pot to 180 r / min, and wait for the liquid to cool to 38 °C. At the same time, dissolve each extract with an appropriate amount of propylene glycol and ethanol, where the volume ratio of propylene glycol to ethanol is 3:1, to obtain a mixed solution. When the temperature in the main pot reaches 38 °C, slowly add the dissolved extracts in sequence, stir for 8 minutes after each addition, and stir for another 25 minutes after all additions to ensure uniform distribution of the components.

[0036] Step 4, Filtration and Inspection of the Discharge: Filter the gel with a 120-mesh sieve to remove impurities. Conduct strict inspection on the semi-finished product. In addition to the appearance and pH value, whose target range is 6.4 - 6.6, and the microbial limit inspection, the heavy metal content inspection is also added, and it is ensured that the heavy metal contents of lead and mercury meet the national standards. If the inspection fails, analyze the reasons and make improvements.

[0037] Step 5, Filling, Packaging and Final Inspection of the Product: Fill the semi-finished product into brown glass bottles according to the specification of 20 g / bottle, ensuring aseptic operation and accurate dosage during the filling process. After packaging, conduct a full inspection on the finished product. The inspection contents include the appearance. Invert the bottle to observe whether there is liquid leakage to check its sealing performance. Place it in environments of 50 °C (high temperature) and -5 °C (low temperature) for 3 days respectively to observe the product stability. Stick a complete label on the qualified finished product and stack them neatly in the warehouse, waiting for sale.

[0038] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those of ordinary skill in the art in the said technical field, various changes can also be made without departing from the gist of the present invention.

Claims

1. A gel for sensitive skin repair, including a gel formula and a production process of the gel, characterized in that, The gel formulation includes: purslane extract 0.2%, notoginseng extract 0.5%, witch hazel extract 0.5%, chamomile extract 0.5%, cortex dictamni extract 0.1%, biota orientalis extract 0.5%, acrylate / C10-30 alkyl acrylate crosspolymer 0.5%, and purified water. The pH value of the final product is about 6.5; The manufacturing process of the gel includes the following steps: Step 1: Add water, propylene glycol, glycerol, hexylene glycol, p-hydroxyacetophenone, acrylate / C10-30 alkyl acrylate crosspolymer, and disodium EDTA into the water phase pot, heat to 70°C - 75°C, and stir to dissolve evenly; Step 2: Pump the materials in the water phase pot into the main pot and stir to cool down to below 40°C; Step 3: Sequentially add the pre-dissolved witch hazel water, chamomile extract, biota orientalis extract, purslane extract, cortex dictamni extract, and notoginseng extract into the main pot and stir to dissolve evenly; Step 4: Filter and discharge the material for semi-finished product inspection; Step 5: Fill and package, and store in the warehouse after passing the finished product inspection.

2. The gel for sensitive skin repair according to claim 1, characterized in that, The flavonoids in the purslane extract have antioxidant and anti-inflammatory activities, can inhibit inflammatory cytokines, and inhibit the synthesis of inflammatory mediators histamine and prostaglandin; the alkaloids in the purslane extract have antibacterial effects, and the polysaccharides in the purslane extract participate in immune regulation.

3. The gel for sensitive skin repair according to claim 1, wherein The notoginsenosides in the notoginseng extract have anti-inflammatory effects and can inhibit the release of inflammatory cytokines; the notoginseng extract also has antibacterial activity and can inhibit the growth of bacteria such as propionibacterium acnes; at the same time, the notoginseng extract can inhibit the excessive differentiation of sebaceous gland cells, reduce sebum secretion, and can also accelerate the proliferation of epidermal cells and reduce the erythema and scar formation after skin injury.

4. A gel for sensitive skin repair according to claim 1, characterized in that, The witch hazel extract is rich in antioxidant components, can scavenge free radicals in the body, and reduce the damage of oxidative stress to skin cells.

5. A gel for sensitive skin repair according to claim 1, characterized in that, The chamomile extract has anti-inflammatory and soothing effects, can reduce the inflammatory reaction of the skin, and relieve the symptoms of skin redness, swelling, itching and discomfort.

6. The gel for sensitive skin repair according to claim 1, characterized in that, The cortex dictamni extract has antibacterial and anti-inflammatory effects, can inhibit a variety of bacteria and fungi, can reduce skin inflammation, and promote skin repair.

7. A gel for sensitive skin repair according to claim 1, characterized in that, The biota orientalis extract has antibacterial, anti-inflammatory and antioxidant properties, can inhibit the growth of bacteria and fungi, reduce the inflammatory reaction, scavenge free radicals, and protect skin cells.

8. A gel for sensitive skin repair according to claim 1, characterized in that, The acrylate / C10-30 alkyl acrylate crosspolymer is used to adjust the texture and stability of the gel, make the gel have an appropriate consistency and form, and is convenient for spreading and use.

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