Penetration enhancer and preparation method of penetration enhancer

Abstract

The invention discloses a penetration enhancer and a preparation method of the penetration enhancer, and relates to the technical field of biological medicines.The penetration enhancer comprises borneol, menthol, 95% ethyl alcohol, azone and purified water, the borneol is natural borneol, multiple layers of driven parts which can rotate and move up and down are sequentially arranged in a mixing device body from top to bottom, and the driven parts are connected with the purified water. A plurality of driving belts are fixedly connected between the first-layer driven component and the second-layer driven component, and a plurality of stirring components are arranged between the second-layer driven component and the third-layer driven component. According to the manufacturing method of the penetration enhancer and the preparation, azone is combined with borneol, menthol, 95% ethyl alcohol, purified water and other components, and the penetration enhancer is prepared. Azone can reduce the barrier effect of eye tissues, help effective components of the eye pad to permeate more easily and enhance the effect of the eye pad, and the unique molecular structure of azone can assist in dissolution and dispersion of insoluble drugs and promote the drugs to penetrate through eye barriers.

Description

Technical Field

[0001] The present invention relates to the field of biomedical technologies. More specifically, the present invention relates to a penetration enhancer and a manufacturing method of the preparation. Background Art

[0002] With the change of people's lifestyles, bad habits such as long-term use of electronic devices and staying up late have led to an increasingly common occurrence of eye problems, such as eye fatigue, dryness, and decreased eyesight. As a convenient eye care product, eye patches have gradually gained favor among consumers. Its principle of action is to apply on the surface of the eye skin, enabling the active ingredients to penetrate into the eye tissues, thereby exerting the effect of relieving eye discomfort.

[0003] However, the special physiological structure of the eye tissues poses many challenges to the penetration of drugs. There are multiple layers of barriers in the eye. Taking the cornea as an example, its epithelial layer is rich in lipids and has a strong blocking effect on hydrophilic drugs; while the endothelial layer has abundant aqueous channels, which is not conducive to the penetration of lipophilic drugs. The conjunctiva also has a certain barrier function, and the eye has a rich blood circulation, so drugs are easily cleared quickly and it is difficult to maintain an effective therapeutic concentration in the eye. Therefore, penetration enhancers are widely used in eye patches. Penetration enhancers can significantly improve the penetration efficiency of drugs through various mechanisms, such as changing the barrier structure of the eye skin or the cornea and conjunctiva, increasing the solubility and diffusion coefficient of drugs, etc., bringing new opportunities for the development of eye patches.

[0004] In modern medicine and skin care products and other fields, penetration enhancers play an indispensable and important role, and their applications are extremely extensive. In the production process of penetration enhancers, in order to achieve the goal of uniform fusion of all drug components, the mixing device becomes a key piece of equipment. Through this device, drugs with different characteristics and effects can be effectively mixed to ensure the stability of the product quality and performance. For example, in the patent "A penetration-enhancing cataplasm matrix and its preparation method" with the application number 200610013798.9, efforts are made in the research and development and preparation of penetration-enhancing cataplasm matrices. In its production process, a variety of raw materials are fully mixed by means of a mixing device to create a cataplasm matrix with excellent performance; in the patent "Penetration enhancer, skin care product containing the penetration enhancer and its preparation method" with the application number 201911406338.6, which focuses on penetration enhancers and related skin care products, a mixing device is also used to uniformly mix the penetration enhancer with other components in the skin care product to ensure that the skin care product has an ideal penetration-enhancing effect and user experience;

[0005] Although the above-mentioned patent can mix solutions, there are often some solid materials in existing penetration enhancers. In the manufacturing process of conventional penetration enhancers, traditional techniques usually operate the grinding device and the mixing device separately and independently. From the perspective of production efficiency theory, this separated operation mode means that materials need to be transferred between different devices, increasing the operation steps and time costs, and greatly enhancing the complexity of the process;

[0006] Without the aid of a grinding device, if solid materials are directly placed in a solution for dissolution, the mixing time of the materials will increase significantly. According to the tea leaf paradox principle, during the dissolution process, solid materials tend to gather in the central area at the bottom of the solution, which is extremely likely to cause concentration stratification in the solution. Therefore, simply relying on an ordinary mixing device requires a large amount of time to make the solution reach a uniform mixing state, greatly reducing the mixing efficiency. Summary of the Invention

[0007] Aiming at the deficiencies of the prior art, the present invention provides a penetration enhancer and a manufacturing method thereof, solving the problems raised in the above-mentioned background art.

[0008] The technical solution of the present invention is as follows:

[0009] To achieve the above objectives, the present invention is realized through the following technical solutions: A penetration enhancer, comprising borneol, menthol, 95% ethanol, azone and purified water.

[0010] Preferably, the borneol is natural borneol.

[0011] A manufacturing method of a penetration enhancer, comprising the following steps:

[0012] S1: Add natural borneol and menthol into a 95% ethanol solution for dissolution;

[0013] S2: Add azone and purified water into the solution, and at the same time, conduct grinding and stirring through the main body of the mixing device to prepare the penetration enhancer.

[0014] Preferably, multiple driven components that can rotate and move up and down are sequentially arranged from top to bottom inside the main body of the mixing device, and a plurality of drive belts are fixedly connected between the first driven component and the second driven component. A plurality of stirring components are arranged between the second driven component and the third driven component, and a plurality of stirring components are also arranged between the third driven component and the fourth driven component. A secondary rotating rod passes through the second driven component, the third driven component and the fourth driven component. A grinding block capable of crushing solid materials is fixedly connected to the bottom end of the secondary rotating rod, and a speed reduction component capable of reducing the rotation speed of the secondary rotating rod is arranged at the top end of the secondary rotating rod.

[0015] Preferably, a main rotating rod whose one end extends into the mixing device body is rotatably connected to the upper surface of the mixing device body. The first driven component from top to bottom includes a fixing ring fixedly connected to the bottom end of the main rotating rod. A plurality of stirring rods are fixedly connected to the outer peripheral surface of the fixing ring evenly, and the structures of the plurality of driven components are the same.

[0016] Preferably, an auxiliary support column whose one end is inserted into the auxiliary rotating rod is fixedly connected to the center of the inner bottom surface of the mixing device body. The top end of the auxiliary support column is rotatably connected to an auxiliary cylinder, and the inner top surface of the auxiliary rotating rod is also rotatably connected to an auxiliary cylinder. A tension spring is arranged between the two auxiliary cylinders.

[0017] Preferably, the decelerating component includes a decelerating disc fixedly connected to the top end of the auxiliary rotating rod. The top end of the auxiliary support column is fixedly connected to an auxiliary limiting rod. One end of the auxiliary limiting rod away from the auxiliary support column penetrates through the tension spring, the auxiliary rotating rod and the decelerating disc in sequence, and the top end of the auxiliary limiting rod is also rotatably connected to a decelerating disc. A plurality of decelerating clamping bars capable of being clamped together are arranged on the opposite surfaces of the two decelerating discs. Two limiting installation grooves are oppositely formed in the decelerating disc. Two decelerating plates respectively arranged in the corresponding limiting installation grooves are fixedly connected to the opposite sides of the top end of the auxiliary limiting rod. One end of a second spring is fixedly connected to one side of the decelerating plate and arranged on the inner side surface of the limiting installation groove.

[0018] Preferably, an annular gathering groove is formed in the center of the inner bottom surface of the mixing device body. The lower surface of the grinding block and the inner bottom surface of the gathering groove are both relatively rough.

[0019] Preferably, the stirring component includes a rotating shaft fixedly connected between two adjacent upper and lower stirring rods. A plurality of stirring plates capable of forming inclined surfaces on both sides are arranged on the circumferential surface of the rotating shaft from top to bottom.

[0020] Preferably, a second arc-shaped block is fixedly connected to the inner circumferential surface of each stirring plate. The inner side surface of the second arc-shaped block is attached to the rotating shaft. A first arc-shaped block is fixedly connected to the position on the circumferential surface of the rotating shaft adapted to each stirring plate. The outer side surface of the first arc-shaped block is attached to the inner circumferential surface of the stirring plate. A hidden groove is formed at one end of the second arc-shaped block. One end of a first spring is fixedly connected to the inner side surface of the hidden groove and arranged on the first arc-shaped block. And the maximum rotation angle of the stirring plates on each rotating shaft gradually increases from bottom to top.

[0021] Beneficial effects

[0022] The present invention provides a penetration enhancer and a manufacturing method of the preparation, having the following beneficial effects:

[0023] 1. The preparation method of this penetration enhancer and this preparation can significantly enhance the penetration effect by combining azone with borneol, menthol, 95% ethanol, purified water and other components. Azone can reduce the barrier effect of eye tissues, help the active ingredients of eye patches penetrate more easily, and enhance the efficacy of eye patches; its unique molecular structure can assist in the dissolution and dispersion of poorly soluble drugs and promote the penetration of drugs through the eye barrier; in synergy with borneol and menthol, it can enhance the soothing regulation of the eye nerves; in synergy with ethanol, it enhances the overall penetration effect. This way of combining components comprehensively optimizes the performance of the penetration enhancer to overcome the hindrance of the special physiological structure of eye tissues to drug penetration, providing strong support for eye patches to better play roles such as relieving eye discomfort.

[0024] 2. The preparation method of this penetration enhancer and this preparation can efficiently mix the penetration enhancer solution by setting multiple rotatable and vertically movable driven components, drive belts, stirring components, grinding blocks, and deceleration components in the main body of the mixing device. The drive belt drives the driven components to rotate and move upward. At the same time, the auxiliary rotating rod and the grinding block move synchronously, using the tea leaf paradox to make solid materials gather in the gathering groove for grinding and crushing; the deceleration component changes the rotation speed of the auxiliary rotating rod, destroys the solution vortex, and enhances the mixing effect; the "pushing plate" structure composed of stirring plates uses the mechanical principle to make the solution generate a circular rotation and an upward movement trend, promoting the exchange and fusion of the solution at the bottom and the top, and can also form small vortices to expand the mixing range, and the rotation of the stirring plates makes the mixing more flexible and efficient. This manufacturing method and device design effectively solve problems such as the separation of grinding and mixing and uneven solution mixing in traditional processes, and greatly improve the mixing efficiency of the production of penetration enhancers. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0026] Figure 2 It is a schematic cross-sectional structure view of the front view of the main body of the mixing device of the present invention;

[0027] Figure 3 For the present invention Figure 2 The enlarged schematic diagram of the structure at A in;

[0028] Figure 4 For the present invention Figure 2 The enlarged schematic diagram of the structure at B in;

[0029] Figure 5 It is a schematic diagram of the cooperation structure of the speed reduction disc, speed reduction plate and the second spring of the present invention;

[0030] Figure 6 It is a schematic top view structure diagram of the stirring rod of the present invention;

[0031] Figure 7 For the present invention Figure 6Schematic diagram of the enlarged structure at position C in the [Chinese context];

[0032] Figure 8 This is a top - view sectional structure diagram of the stirring plate of the present invention;

[0033] Figure 9 This is a structure diagram of the speed - reducing disc of the present invention.

[0034] In the figure: 1. Main body of the mixing device; 2. Main rotating rod; 3. Fixed ring; 4. Stirring rod; 5. Driving belt; 6. Speed - reducing disc; 7. Speed - reducing bar; 8. Stirring plate; 9. Sub - rotating rod; 10. Auxiliary support column; 11. Tension spring; 12. Grinding block; 13. Aggregation groove; 14. Rotating shaft; 15. First arc - shaped block; 16. Second arc - shaped block; 17. First spring; 18. Hidden groove; 19. Auxiliary limiting rod; 20. Auxiliary cylinder; 21. Speed - reducing plate; 22. Second spring; 23. Auxiliary inclined plane. Detailed implementation mode

[0035] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0036] Embodiment 1

[0037] In the current eye patch market, penetration enhancers play a crucial role in enhancing the efficacy of eye patches. The active ingredients of eye patches need to penetrate through complex physiological barriers of the eyes, such as the cornea, conjunctiva, etc., to reach the action site and play effects such as relieving eye fatigue and improving microcirculation of the eyes. However, the existing eye patch penetration enhancer systems have obvious defects;

[0038] Existing penetration enhancers often rely only on a few traditional ingredients, such as simple alcohols, natural plant extracts, etc. Although these ingredients have a certain penetration - enhancing effect, their penetration - enhancing efficiency is far lower than that of azone. Taking commonly used ethanol as an example, its penetration - enhancing mechanism is relatively single, mainly promoting drug penetration by changing the hydration state of the skin stratum corneum, and has limited effects on the complex and tight barrier structure of the eyes, making it difficult to significantly increase the amount of drug entering the eye. Natural plant extract - based penetration enhancers, such as some essential oils with volatility, although having high safety, have unstable penetration - enhancing effects, and the penetration - enhancing performance of products in different batches varies greatly, resulting in uneven quality of eye patch products. To solve the above problems, this embodiment is specifically invented.

[0039] The present invention provides a technical solution: a penetration enhancer, comprising borneol, menthol, 95% ethanol, azone and purified water.

[0040] The borneol is natural borneol;

[0041] There are various barriers in ocular tissues, such as the lipid barrier in the corneal epithelium layer, etc., which will hinder the absorption of drugs. Azone can reduce the barrier effect of ocular tissues such as the cornea, enabling active ingredients in the eye patch, such as borneol and menthol, to more easily penetrate tissues such as the cornea and conjunctiva and enter the eye, improving the bioavailability of drugs in the eye, thereby enhancing the effects of the eye patch in relieving eye fatigue and improving ocular microcirculation, etc.;

[0042] Some components in the eye patch may have poor water solubility or lipid solubility, resulting in difficulty in penetrating ocular tissues. Azone has a unique molecular structure and properties, being both lipophilic and having a certain degree of hydrophilicity, which can help these poorly soluble drugs dissolve and disperse better, promoting their penetration through the lipid and aqueous barriers of the eye, enabling the drugs to reach the site of action more effectively;

[0043] Synergistic with borneol and menthol: Borneol and menthol have effects such as cooling and opening the orifices. Azone can promote their faster and deeper penetration into ocular tissues, enhancing their soothing and regulating effects on ocular nerves, and better exerting the effects of relieving ocular discomfort and reducing eye fatigue;

[0044] Synergistic with ethanol: Ethanol can help dissolve azone and other drug components, enabling azone to better exert its permeation-enhancing effect. At the same time, ethanol itself also has a certain effect of promoting drug penetration. The two working together can enhance the overall permeation-enhancing effect.

[0045] Example Two

[0046] After solving the problems regarding the components of the permeation enhancer, there is still room for improvement in the manufacturing process of the permeation enhancer. In the conventional manufacturing process of the permeation enhancer, traditional processes usually operate the grinding device and the mixing device separately and independently. From the perspective of production efficiency theory, this separate operation mode means that materials need to be transferred between different devices, increasing the operation steps and time costs, and greatly enhancing the complexity of the process. For example, during the material transfer process, not only additional manpower and time are required to complete the transportation, but there may also be material losses or external contamination due to the transfer link.

[0047] Meanwhile, when the mixing device performs the mixing operation on the solution, according to the principle of fluid mechanics, water vortices are extremely likely to form in the mixing device. From the perspective of mixing kinetics, the ideal mixing state should be that each component of the solution can be quickly and evenly dispersed in the device. However, the existence of water vortices will seriously interfere with this ideal state. The vortices cause the flow rate of the solution to be too fast in some areas and too slow in some areas, resulting in uneven mixing. In the areas with a fast flow rate, the mixing time of the materials is short, and it is difficult to fully blend with other components; while in the areas with a slow flow rate, local high or low concentrations are likely to form, which seriously hinders the improvement of the overall mixing efficiency of the solution and is extremely unfavorable for the efficient and high-quality production of the penetration enhancer. To solve the above problems, this embodiment is specifically invented.

[0048] Based on the above embodiment, the present invention provides a technical solution: a method for manufacturing a penetration enhancer, comprising the following steps:

[0049] S1: Add natural borneol and menthol into a 95% ethanol solution for dissolution;

[0050] S2: Add azone and purified water into the solution, and at the same time, perform grinding and stirring through the mixing device body 1 to prepare the penetration enhancer.

[0051] Among them, natural borneol and menthol need to be ground.

[0052] Please refer to Figures 1 to 9 , a plurality of driven components that can rotate and move up and down are sequentially arranged in the mixing device body 1 from top to bottom. A plurality of drive belts 5 are fixedly connected between the first driven component and the second driven component, and a plurality of stirring components are arranged between the second driven component and the third driven component, and a plurality of stirring components are also arranged between the third driven component and the fourth driven component. A secondary rotating rod 9 passes through the second driven component, the third driven component, and the fourth driven component. Among them, the second driven component, the third driven component, the fourth driven component, and the secondary rotating rod 9 are all fixedly connected. A grinding block 12 capable of crushing solid materials is fixedly connected to the bottom end of the secondary rotating rod 9, and a deceleration component capable of reducing the rotation speed of the secondary rotating rod 9 is arranged at the top end of the secondary rotating rod 9.

[0053] Please refer to Figure 2 , the upper surface of the mixing device body 1 is rotatably connected with a main rotating rod 2 whose one end extends into the mixing device body 1. The first driven component from top to bottom includes a fixed ring 3 fixedly connected to the bottom end of the main rotating rod 2. A plurality of stirring rods 4 are uniformly fixedly connected to the outer peripheral surface of the fixed ring 3, and the structures of the plurality of driven components are the same;

[0054] Above the main body 1 of the mixing device, a driving motor is installed. The top end of the main rotating rod 2 is firmly connected to the rotating shaft of the driving motor. When the driving motor starts to operate, it can drive the main rotating rod 2 to rotate synchronously. During the rotation of the main rotating rod 2, the fixed ring 3 connected thereto will be driven to rotate together, and the fixed ring 3 will drive a plurality of stirring rods 4 thereon to rotate synchronously;

[0055] At the same time, the upper and lower ends of the driving belt 5 are respectively fixedly connected to the corresponding stirring rods 4. When the main rotating rod 2 rotates driven by the driving motor and then drives the stirring rods 4 to rotate synchronously, the torque will be transmitted to the second-layer driven component through the driving belt 5, causing it to start rotating. When the stirring rods 4 initially drive the second-layer driven component to operate through the driving belt 5, since the initial tensions of the driving belts 5 are not exactly the same and the positions of the stirring rods 4 are constantly changing in the circular motion, according to the theory of force synthesis and decomposition, the plurality of driving belts 5 will first undergo irregular torsion and then drive the second-layer driven component to rotate. As the rotation continues, according to the principle of conservation of angular momentum, the rotation speed of the second-layer driven component will gradually increase and approach the rotation speed of the stirring rods 4. At this time, since the centrifugal force acting on the driving belt 5 increases with the increase in the rotation speed, the middle part of the driving belt 5 will bulge outwards due to the centrifugal force, so that the driving belt 5 forms an arc. This arc-shaped driving belt 5 will exert an upward component force on the second-layer driven component during the rotation. According to the principle that the action of force is mutual and the principle of force decomposition, the second-layer driven component will move upward while rotating.

[0056] Please refer to Figures 2 to 3 , at the center of the inner bottom surface of the main body 1 of the mixing device, an auxiliary support column 10 with one end inserted into the auxiliary rotating rod 9 is fixedly connected. The auxiliary rotating rod 9 can slide up and down on the auxiliary support column 10 and can also rotate. The top end of the auxiliary support column 10 is rotatably connected to an auxiliary cylinder 20, and the inner top surface of the auxiliary rotating rod 9 is also rotatably connected to an auxiliary cylinder 20. A tension spring 11 is arranged between the two auxiliary cylinders 20;

[0057] Through the arrangement of the two auxiliary cylinders 20 and the tension spring 11, when the auxiliary rotating rod 9 rotates, it can be ensured that the tension spring 11 is not interfered by its rotation action. During the process of the auxiliary rotating rod 9 moving up and down along the auxiliary support column 10, the tension spring 11 can be normally stretched or contracted according to the position change of the auxiliary rotating rod 9, ensuring the stable operation of the entire mechanical structure.

[0058] Please refer to Figures 2 to 5, the deceleration component includes a deceleration disk 6 fixedly connected to the top end of the secondary rotating rod 9. The top end of the auxiliary support column 10 is fixedly connected with an auxiliary limiting rod 19. One end of the auxiliary limiting rod 19 far away from the auxiliary support column 10 sequentially penetrates through the tension spring 11, the secondary rotating rod 9 and the deceleration disk 6. There is no contact between the tension spring 11, the secondary rotating rod 9, the deceleration disk 6 and the auxiliary limiting rod 19 (here the deceleration disk 6 is fixedly connected to the secondary rotating rod 9). At the same time, both of the two auxiliary cylinders 20 are penetrated by the auxiliary limiting rod 19, and there is also a gap between them and the auxiliary limiting rod 19. The top end of the auxiliary limiting rod 19 is also rotatably connected with a deceleration disk 6. A plurality of deceleration clamping strips 7 that can be clamped together are arranged on the opposite surfaces of the two deceleration disks 6. Two limiting installation grooves are oppositely opened in the deceleration disk 6. Two deceleration plates 21 respectively arranged in the corresponding limiting installation grooves are fixedly connected to the opposite sides of the top end of the auxiliary limiting rod 19. One end of the deceleration plate 21 far away from the auxiliary limiting rod 19 abuts against the inner side surface of the limiting installation groove. One side of the deceleration plate 21 is fixedly connected with a second spring 22 with one end arranged on the inner side surface of the limiting installation groove. Therefore, when an external force acts on the deceleration disk 6, it will cause the deceleration disk 6 to rotate counterclockwise (seen from Figure 5 ), so the second spring 22 will be compressed. When the external force on the deceleration disk 6 disappears, the deceleration disk 6 will return to its initial position through the elastic force released by the second spring 22;

[0059] Please refer to Figure 2 , a ring-shaped aggregation groove 13 is opened at the center of the inner bottom surface of the mixing device body 1. The lower surfaces of the grinding blocks 12 and the inner bottom surface of the aggregation groove 13 are both relatively rough;

[0060] When the second-layer driven component moves up and down and rotates, the setting of the secondary rotating rod 9 enables the third-layer driven component and the fourth-layer driven component to move and rotate synchronously. At the same time, the grinding block 12 will also move synchronously with the secondary rotating rod 9. The solid substances in the solution will gradually aggregate in the aggregation groove 13 due to the opening of the aggregation groove 13 and the tea leaf paradox principle. The tea leaf paradox states that when a fluid rotates, particulate matter will aggregate near the central axis, and the special structure of the aggregation groove 13 strengthens this effect. Therefore, when the grinding block 12 moves upward following the secondary rotating rod 9, the solid substances will enter the aggregation groove 13 along with the trend. When the grinding block 12 falls back to the initial position downward, it will crush and grind the solid materials in the aggregation groove 13, greatly improving the mixing efficiency of the solution;

[0061] When the auxiliary rotating rod 9 moves upward by means of the second layer of driven components, the grinding block 12 connected to it will be driven to rise synchronously. During this process, the deceleration disc 6 fixed on the auxiliary rotating rod 9 will gradually approach the deceleration disc 6 fixed on the auxiliary limiting rod 19. As the distance between the two continues to shorten, the deceleration strips 7 set on the two deceleration discs 6 will eventually touch each other. Once the deceleration strips 7 come into contact, the auxiliary rotating rod 9 will encounter resistance when rotating, which greatly reduces the speed of the auxiliary rotating rod 9. At the same time, due to the reduction in the rotation speed of the bottom end of the drive belt 5, the drive belt 5 will have an irregular torsional state, and the upward pulling force generated by the centrifugal force will also be significantly reduced. At this time, the tension spring 11 comes into play, pulling the auxiliary rotating rod 9 to reset. During the resetting process of the auxiliary rotating rod 9, the grinding block 12 takes advantage of the situation to perform precise crushing and grinding operations on the solid matter gathered in the gathering tank 13, thereby effectively completing the material processing work;

[0062] At the same time, when the stirring rod 4 continues to drive the second layer of driven components to rotate again through the driving belt 5, the above-mentioned movement process will be repeated;

[0063] When the driving belt 5 drives the multi-layer driven components to rotate synchronously with the stirring components, the solution in the mixing device body 1 will gradually form a vortex. As the rotation continues, the rotation speed of the solution will continue to increase, gradually approaching the rotation speed of the stirring component. However, when the speed of the auxiliary rotating rod 9 suddenly decreases, the rotation speed of the stirring component will also decrease accordingly. At this time, the high-speed rotating vortex encounters the stirring component with a slower rotation speed. According to the Karman vortex street principle, when the fluid bypasses a non-streamlined object (here refers to the stirring component whose rotation speed suddenly decreases), regular vortices will alternately be generated on both sides of the downstream of the object. This phenomenon will not only cause a significant change in the fluid flow state, but also have an important impact on the mixing effect of the liquid in the mixing device body 1, thereby being able to damage the vortex formed by the solution in the mixing device body 1, thereby greatly increasing its mixing effect.

[0064] Embodiment 3

[0065] In the above embodiment, although the mixing device body 1 can destroy the water vortex formed by the internal solution and can also perform crushing and grinding operations on solid materials. However, since the solid materials dissolve in the solution, the concentration of the solution at the bottom of the mixing device body 1 is higher than that at the top. According to the solution diffusion principle, the solute will diffuse from the high-concentration region to the low-concentration region. However, in the actual mixing process, the elimination of this concentration difference requires a certain amount of time. When the mixing device body 1 attempts to uniformly mix the internal solution, affected by the high-concentration solution at the bottom, it often takes a long time to achieve the uniformity of the overall solution concentration. This is mainly because the concentration gradient between the high-concentration solution at the bottom and the low-concentration solution at the top is relatively large, and the solution diffusion process is relatively slow, resulting in a reduction in the efficiency of the entire mixing process and being unfavorable for quickly and efficiently completing the uniform mixing of the solution. To solve the above problems, this embodiment is specifically invented.

[0066] Please refer to Figures 1 to 9 , on the basis of the above embodiment, the technical solution adopted is that the stirring component includes a rotating shaft 14 fixedly connected between two adjacent upper and lower stirring rods 4. A plurality of stirring plates 8 that can form inclined surfaces on both sides are arranged on the circumferential surface of the rotating shaft 14 from top to bottom. Among them, the rotating shaft 14 is only arranged between the third-layer driven component and the second-layer driven component, and between the third-layer driven component and the fourth driven component.

[0067] Please refer to Figures 1 to 9 , a second arc-shaped block 16 is fixedly connected to the inner circumferential surface of each stirring plate 8. The inner side surface of the second arc-shaped block 16 fits on the rotating shaft 14. A first arc-shaped block 15 is fixedly connected to the position on the circumferential surface of the rotating shaft 14 that is adapted to each stirring plate 8. The outer side surface of the first arc-shaped block 15 fits on the inner circumferential surface of the stirring plate 8. A hidden groove 18 is opened at one end of the second arc-shaped block 16. A first spring 17 with one end arranged on the first arc-shaped block 15 is fixedly connected to the inner side surface of the hidden groove 18. And for the stirring plates 8 on each rotating shaft 14, the maximum rotation angle of each of them gradually increases from bottom to top. In addition, on each stirring plate 8, when observing from the top to the bottom of the rotating shaft 14, the distance between the ends of the second arc-shaped block 16 and the first arc-shaped block 15 connected by the first spring 17 shows a gradually shortening pattern. That is to say, the distance between the connecting ends of the second arc-shaped block 16 and the first arc-shaped block 15 connected by the first spring 17 on the upper stirring plate 8 is greater than the distance between the corresponding connecting ends on the lower stirring plate 8;

[0068] When the stirring rod 4 drives the rotating shaft 14 to rotate synchronously, the rotating shaft 14 will drive the multiple stirring plates 8 thereon to rotate together. Since there are differences in the maximum rotation angles of the respective stirring plates 8 on the rotating shaft 14, when the secondary rotating rod 9 rotates counterclockwise (from Figure 6When the stirring rod 4 is driven to rotate from a perspective view, based on Newton's third law in fluid mechanics, that is, the law of action and reaction, when each stirring plate 8 agitates the solution, the solution will exert an equal and opposite reaction force on the stirring plate 8. In addition, auxiliary inclined surfaces 23 are provided on both opposite sides of each stirring plate 8. Under the action of this reaction force, the stirring plate 8 will rotate around the rotating shaft 14. In this way, the stirring plates 8 on each rotating shaft 14 together form a "pushing plate" structure similar to having two "inclined surfaces" inclined upward.

[0069] Analyzing from the perspective of the action of force, when the inclined surface of the pushing plate drives the liquid to rotate, according to the principle of interaction of forces, the inclined surface will exert an inclined upward force on the solution in contact with it. According to the theory of force decomposition, this inclined upward force can be decomposed into component forces in the horizontal and vertical directions. The horizontal component force causes the solution to rotate in a circular motion following the pushing plate, while the vertical component force enables the solution to have an upward movement tendency while rotating.

[0070] As the pushing plate continues to rotate, different positions on its inclined surface continuously exert this inclined upward force on the solution. Under the continuous action of multiple forces, the upward movement tendency of the solution is continuously accumulated and strengthened. This upward movement tendency caused by the force enables the solution at the bottom of the mixing device body 1 to achieve more sufficient exchange and fusion with the solution at the top. According to the mixing efficiency theory, the faster the mass exchange rate between different regions of the solution, the higher the mixing efficiency. Therefore, the pushing plate composed of the stirring plates 8 greatly improves the mixing efficiency of the solution in the mixing device body 1 through this unique mechanical action method, realizing a more efficient solution mixing operation.

[0071] At the same time, since the stirring plate 8 is provided with an auxiliary inclined surface 23, it will guide the solution to flow in a specific direction during rotation, forming local small eddies. These small eddies can drive the surrounding solution to participate in the flow, enabling the mixing effect not only to be limited near the stirring plate 8 but also to be transmitted to a wider area, which helps to expand the mixing range.

[0072] When the stirring plate 8 slowly moves upward, it will drive the surrounding solution to move upward together, forming a vertical convection. This phenomenon can be explained based on the "boundary layer theory" in fluid dynamics. When the stirring plate 8 moves, the solution layer in direct contact with the plate will move together with the stirring plate 8 due to the action of viscous force, and then drive the adjacent solution layer, forming a layer-by-layer driving effect, ultimately triggering the overall upward flow of the solution;

[0073] In terms of viscous force, the fluid has viscosity. When the stirring plate 8 moves slowly upward, due to the adhesion between the solution and the surface of the stirring plate 8, the layer of solution in direct contact with the stirring plate 8 will be "pulled" by the viscous force and move upward together with the stirring plate 8. This is because the intermolecular force makes the solution molecules "adhere" to the surface of the stirring plate 8 and thus be driven.

[0074] At the same time, when the solution in the mixing device body 1 rotates, the rotation speed of the solution will gradually catch up with the pushing plate. Therefore, a rotation phenomenon will occur in the torsion angle of each stirring plate 8. Because the reaction force of the solution on the stirring plate 8 will change with the change of the motion state of the solution. When the rotation speed of the solution gradually approaches the rotation speed of the pushing plate, the acting force of the solution on the stirring plate 8 will decrease, causing a change in the resultant force received by the stirring plate 8, resulting in the torsion angle not reaching the maximum rotation angle, thus showing a certain degree of rotation. However, the "pushing plate" structure formed by the stirring plates 8 on each rotating shaft 14, which resembles a structure with two "inclined surfaces" sloping upward, still exists;

[0075] When the stirring plate 8 rotates, the angle of each stirring plate 8 will be continuously adjusted according to the reaction force and motion state of the solution. This rotation can keep a certain relative speed between the stirring plate 8 and the solution all the time, continuously and effectively apply force to the solution, and maintain the efficient mixing of the solution. Moreover, the rotation makes the action of the stirring plate 8 on the solution more flexible, the solution flow path more complex and diverse, increasing the exchange and collision of the solution between different regions, which helps to further improve the mixing uniformity and efficiency. In addition, the rotation can also adapt to the continuously changing flow characteristics of the solution during the mixing process, enabling the mixing device to maintain a good mixing effect under different solution concentrations, viscosities and other conditions.

[0076] When the rotation speed of the auxiliary rotating rod 9 drops suddenly, according to the inertia principle, the originally fast-rotating solution still has the tendency to move at a high speed and will violently impact the other "inclined surface" of the "pushing plate". According to the momentum theorem, during the collision process between the moving solution and the pushing plate, a downward acting force will be applied to the pushing plate. This force is transmitted to the auxiliary rotating rod 9 through rigid connecting components such as the stirring rod 4 and the fixing ring 3 in accordance with the force transmission principle, and finally acts on the grinding block 12.

[0077] From the perspective of energy conversion, the kinetic energy generated by the solution impact is converted into the mechanical energy of the grinding block 12, significantly enhancing the impact crushing force of the grinding block 12 on the solid materials gathered in the gathering groove 13. According to the grinding principle, a greater impact force can increase the degree and speed of solid material crushing, and the grinding effect is thus improved. And a better grinding effect can make the solid materials more finely and evenly dispersed in the solution, accelerating mass transfer, and then, according to the mixing efficiency theory, significantly improving the mixing efficiency.

[0078] In summary, when the penetration enhancer and the manufacturing method of the preparation are used, the operator can add the material to the inside of the mixing device body 1 from the top. A switching valve is provided at the bottom of the mixing device body 1. After the penetration enhancer mixing process is completed, the operator only needs to rotate the switching valve to discharge the material in the mixing device body 1. At the same time, the maximum height of the solution in the mixing device body 1 will not exceed the second driven component either.

[0079] It should be noted that in the description of the present invention, the terms indicating directions or positional relationships such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings. This is only for convenience of description and does not indicate or imply that the device or component must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation of the present invention. In addition, the terms "first", "second", "third" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0080] In addition, it should also be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installation", "connection", "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0081] The above is only the preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and should be covered by the protection scope of the present invention.

Claims

1. A penetration enhancer, characterized in that: It includes borneol, menthol, 95% ethanol, azone and purified water.

2. The penetration enhancer according to claim 1, characterized in that: The borneol is natural borneol.

3. A method for manufacturing a penetration enhancer, implemented based on claim 2, characterized in that, It includes the following steps: S1: Add natural borneol and menthol into 95% ethanol solution for dissolution; S2: Add azone and purified water into the solution, and at the same time, carry out grinding and stirring through the mixing device body (1) to make a penetration enhancer.

4. The manufacturing method of a penetration enhancer according to claim 3, characterized in that: Inside the mixing device body (1), there are multiple driven components arranged from top to bottom that can all rotate and move up and down. And a plurality of drive belts (5) are fixedly connected between the first-layer driven component and the second-layer driven component. A plurality of stirring components are arranged between the second-layer driven component and the third-layer driven component, and a plurality of stirring components are also arranged between the third-layer driven component and the fourth-layer driven component. And a secondary rotating rod (9) passes through the second-layer driven component, the third-layer driven component and the fourth-layer driven component. The bottom end of the secondary rotating rod (9) is fixedly connected with a grinding block (12) that can crush solid materials. The top end of the secondary rotating rod (9) is provided with a deceleration component that can reduce the rotation speed of the secondary rotating rod (9).

5. The manufacturing method of a penetration enhancer according to claim 4, characterized in that: The upper surface of the mixing device body (1) is rotatably connected with a main rotating rod (2) whose one end extends into the mixing device body (1). The first driven component from top to bottom includes a fixed ring (3) fixedly connected to the bottom end of the main rotating rod (2). A plurality of stirring rods (4) are evenly fixedly connected to the outer peripheral surface of the fixed ring (3), and the structures of the plurality of driven components are the same.

6. The manufacturing method of a penetration enhancer according to claim 5, characterized in that: The center of the inner bottom surface of the mixing device body (1) is fixedly connected with an auxiliary support column (10) whose one end is inserted into the secondary rotating rod (9). The top end of the auxiliary support column (10) is rotatably connected with an auxiliary cylinder (20). The inner top surface of the secondary rotating rod (9) is also rotatably connected with an auxiliary cylinder (20). A tension spring (11) is arranged between the two auxiliary cylinders (20).

7. The manufacturing method of a penetration enhancer according to claim 6, characterized in that: The deceleration component includes a deceleration disk (6) fixedly connected to the top end of the secondary rotating rod (9). The top end of the auxiliary support column (10) is fixedly connected with an auxiliary limit rod (19). One end of the auxiliary limit rod (19) far from the auxiliary support column (10) sequentially penetrates through the tension spring (11), the secondary rotating rod (9) and the deceleration disk (6), and the top end of the auxiliary limit rod (19) is also rotatably connected with a deceleration disk (6). A plurality of deceleration clamping strips (7) that can be clamped together are arranged on the opposite surfaces of the two deceleration disks (6). Two limit installation grooves are relatively opened inside the deceleration disk (6). Two deceleration plates (21) respectively arranged in the corresponding limit installation grooves are relatively fixedly connected to the top end of the auxiliary limit rod (19). One side of the deceleration plate (21) is fixedly connected with a second spring (22) whose one end is arranged on the inner side surface of the limit installation groove.

8. The manufacturing method of a penetration enhancer according to claim 7, characterized in that: An annular aggregation groove (13) is opened at the center of the inner bottom surface of the mixing device body (1). The lower surface of the grinding block (12) and the inner bottom surface of the aggregation groove (13) are both rough.

9. The manufacturing method of a penetration enhancer according to claim 8, characterized in that: The stirring member includes a rotating shaft (14) fixedly connected between two adjacent upper and lower stirring rods (4), and a plurality of stirring plates (8) capable of forming inclined surfaces on both sides are arranged on the circumferential surface of the rotating shaft (14) from top to bottom.

10. The manufacturing method of a penetration enhancer according to claim 9, wherein: A second arc-shaped block (16) is fixedly connected to the inner circumferential surface of each stirring plate (8). The inner side surface of the second arc-shaped block (16) is attached to the rotating shaft (14). A first arc-shaped block (15) is fixedly connected to the position on the circumferential surface of the rotating shaft (14) adapted to each stirring plate (8). The outer side surface of the first arc-shaped block (15) is attached to the inner circumferential surface of the stirring plate (8). A hidden groove (18) is formed at one end of the second arc-shaped block (16). A first spring (17) with one end disposed on the first arc-shaped block (15) is fixedly connected to the inner side surface of the hidden groove (18). Moreover, the maximum rotation angles of the stirring plates (8) on each rotating shaft (14) gradually increase from bottom to top.

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