A penetration enhancer and a method for manufacturing the same

Abstract

The application discloses a kind of penetration enhancer and the manufacturing method of the preparation, it is related to biological medicine technical field, including borneol, menthol, 95% ethanol, azone and purified water, the borneol is natural borneol, the driven component that multiple layers can rotate and move up and down is sequentially arranged in the mixing device body from top to bottom, and multiple drive belts are fixedly connected between the first layer driven component and the second layer driven component, multiple stirring components are arranged between the second layer driven component and the third layer driven component, the penetration enhancer and the manufacturing method of the preparation, by combining azone with borneol, menthol, 95% ethanol, purified water and other components, can reach the effect of significantly improving the penetration effect, azone can reduce the ocular tissue barrier effect, help eye patch active ingredient to penetrate more easily, enhance eye patch efficacy, its unique molecular structure can assist the dissolution and dispersion of poorly soluble drugs, promote drug penetration ocular barrier.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, and more specifically, to a penetration enhancer and a method for manufacturing the same. Background Technology

[0002] With changing lifestyles, prolonged use of electronic devices and late nights have led to increasingly common eye problems, such as eye fatigue, dryness, and decreased vision. Eye patches, as a convenient eye care product, are gradually gaining popularity among consumers. Their working principle involves applying them to the surface of the skin around the eyes, allowing the active ingredients to penetrate the eye tissues and relieve eye discomfort.

[0003] However, the unique physiological structure of the eye tissues presents numerous challenges to drug penetration. The eye has multiple barriers. For example, the cornea's epithelium is rich in lipids, which strongly blocks hydrophilic drugs; while the endothelium has abundant aqueous channels, hindering the penetration of lipophilic drugs. The conjunctiva also has a certain barrier function, and the eye has a rich blood supply, making it easy for drugs to be rapidly eliminated and difficult to maintain an effective therapeutic concentration within the eye. Therefore, penetration enhancers are widely used in eye patches. These enhancers can significantly improve drug penetration efficiency through various mechanisms, such as altering the barrier structure of the ocular skin, cornea, and conjunctiva, increasing drug solubility and diffusion coefficients, thus bringing new opportunities for the development of eye patches.

[0004] In modern medicine and skincare products, penetration enhancers play an indispensable role and are widely used. In the production of penetration enhancers, a mixing device is crucial to achieve the goal of uniformly blending all drug components. This device effectively mixes drugs with different properties and effects, ensuring the stability of product quality and performance. For example, patent application number 200610013798.9, "A Penetration-Enhancing Poultice Matrix and Its Preparation Method," focuses on the research and preparation of penetration-enhancing poultice matrices. Its production process utilizes a mixing device to thoroughly mix various raw materials, thereby creating a high-performance poultice matrix. Similarly, patent application number 201911406338.6, "Penetration Enhancer, Skincare Product Containing the Penetration Enhancer and Its Preparation Method," focuses on penetration enhancers and related skincare products. It also uses a mixing device to uniformly mix the penetration enhancer with other ingredients in the skincare product, ensuring that the skincare product has an ideal penetration-enhancing effect and user experience.

[0005] While the aforementioned patents demonstrate the ability to mix solutions, existing penetration enhancers often contain solid materials. In conventional penetration enhancer manufacturing processes, grinding and mixing devices are typically operated separately. From a production efficiency perspective, this separate operation mode means that materials need to be transferred between different devices, increasing operational steps and time costs, and significantly enhancing the complexity of the process.

[0006] If solid materials are dissolved directly in a solution without a grinding device, the mixing time will increase significantly. According to the tea paradox, solid materials tend to aggregate in the central region at the bottom of the solution during dissolution, which easily leads to concentration stratification. Therefore, relying solely on ordinary mixing devices requires a considerable amount of time to achieve a uniform mixture, greatly reducing mixing efficiency. Summary of the Invention

[0007] In view of the shortcomings of the prior art, the present invention provides a penetration enhancer and a method for manufacturing the formulation, thereby solving the problems mentioned in the background art.

[0008] The technical solution of this invention is as follows:

[0009] To achieve the above objectives, the present invention is implemented through the following technical solution: a penetration enhancer comprising borneol, menthol, 95% ethanol, azone and purified water.

[0010] Preferably, the borneol is natural borneol.

[0011] A method for manufacturing a penetration enhancer includes the following steps:

[0012] S1: Dissolve natural borneol and menthol in 95% ethanol solution;

[0013] S2: Add azone and purified water to the solution, and simultaneously grind and stir it through the mixing device to make a penetration enhancer.

[0014] Preferably, the mixing device body is provided with multiple layers of driven components that can rotate and move up and down from top to bottom. Multiple drive belts are fixedly connected between the first layer of driven components and the second layer of driven components. Multiple agitating components are provided between the second layer of driven components and the third layer of driven components. Multiple agitating components are also provided between the third layer of driven components and the fourth layer of driven components. A secondary rotating rod is provided through the second layer of driven components, the third layer of driven components and the fourth layer of driven components. A grinding block capable of crushing solid materials is fixedly connected to the bottom end of the secondary rotating rod. A deceleration component capable of reducing the rotation speed of the secondary rotating rod is provided at the top end of the secondary rotating rod.

[0015] Preferably, a main rotating rod extending into the body of the mixing device is rotatably connected to the upper surface of the mixing device body. The first driven component from top to bottom includes a fixing ring fixedly connected to the bottom end of the main rotating rod. Multiple stirring rods are uniformly fixedly connected to the outer circumference of the fixing ring, and the multiple driven components have the same structure.

[0016] Preferably, an auxiliary support column with one end inserted into the secondary rotating rod is fixedly connected to the center of the bottom surface of the mixing device body. An auxiliary cylinder is rotatably connected to the top of the auxiliary support column, and an auxiliary cylinder is also rotatably connected to the inner top surface of the secondary rotating rod. A tension spring is provided between the two auxiliary cylinders.

[0017] Preferably, the deceleration component includes a deceleration disc fixedly connected to the top of the auxiliary rotating rod, an auxiliary limiting rod fixedly connected to the top of the auxiliary support column, the end of the auxiliary limiting rod away from the auxiliary support column passing through a tension spring, the auxiliary rotating rod and the deceleration disc in sequence, and the top of the auxiliary limiting rod is also rotatably connected to the deceleration disc, the opposing surfaces of the two deceleration discs are provided with multiple deceleration clips that can be locked together, two limiting mounting slots are opened opposite each other in the deceleration disc, the top of the auxiliary limiting rod is fixedly connected to two deceleration plates respectively disposed in the corresponding limiting mounting slots, and a second spring is fixedly connected to one side of the deceleration plate with one end disposed on the inner side of the limiting mounting slot.

[0018] Preferably, an annular gathering groove is formed at the center of the bottom surface of the mixing device body, and the lower surface of the grinding block and the inner bottom surface of the gathering groove are relatively rough.

[0019] Preferably, the agitating component includes a rotating shaft fixedly connected between two adjacent agitating rods, and the rotating shaft has multiple agitating plates arranged from top to bottom on its circumference, which can form agitating plates with inclined surfaces on both sides.

[0020] Preferably, a second arc-shaped block is fixedly connected to the inner circumferential surface of each of the agitators, the inner side of the second arc-shaped block is attached to the rotating shaft, a first arc-shaped block is fixedly connected to the position on the circumferential surface of the rotating shaft that is adapted to each agitator, the outer side of the first arc-shaped block is attached to the inner circumferential surface of the agitator, a hidden groove is provided at one end of the second arc-shaped block, a first spring is fixedly connected to the inner side of the hidden groove and one end is provided on the first arc-shaped block, and the maximum rotation angle of each agitator on the rotating shaft gradually increases from bottom to top.

[0021] Beneficial effects

[0022] This invention provides a penetration enhancer and a method for manufacturing the same formulation, which has the following beneficial effects:

[0023] 1. The manufacturing method of this penetration enhancer and the formulation, by combining azone with borneol, menthol, 95% ethanol, purified water, and other components, can significantly improve the penetration effect. Azone can reduce the barrier function of ocular tissues, helping the active ingredients of the eye patch to penetrate more easily and enhancing the efficacy of the eye patch; its unique molecular structure can assist in the dissolution and dispersion of poorly soluble drugs, promoting drug penetration through the ocular barrier; synergistically with borneol and menthol, it can enhance the soothing and regulating effect on the optic nerve; synergistically with ethanol, it enhances the overall penetration-enhancing effect. This combination of components comprehensively optimizes the performance of the penetration enhancer by addressing the obstacles to drug penetration caused by the special physiological structure of ocular tissues, providing strong support for the eye patch to better relieve eye discomfort.

[0024] 2. The manufacturing method of this penetration enhancer and its formulation achieves highly efficient mixing of the penetration enhancer solution by incorporating multiple layers of rotatable and vertically movable driven parts, a drive belt, agitating parts, grinding blocks, and deceleration parts into the mixing device body. The drive belt drives the driven parts to rotate and move upwards, while the auxiliary rotating rod and grinding blocks move synchronously, utilizing the tea paradox to cause solid materials to gather in the gathering tank for grinding and crushing. The deceleration parts change the rotation speed of the auxiliary rotating rod, disrupting the solution eddy and enhancing the mixing effect. The "push plate" structure composed of agitating plates uses mechanical principles to cause the solution to rotate circumferentially and move upwards, promoting the exchange and fusion of the solution at the bottom and top, and also forming small eddies to expand the mixing range. Furthermore, the rotation of the agitating plates makes the mixing more flexible and efficient. This manufacturing method and device design effectively solves the problems of separation between grinding and mixing and uneven solution mixing in traditional processes, significantly improving the mixing efficiency of penetration enhancer production. Attached Figure Description

[0025] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0026] Figure 2 This is a frontal cross-sectional structural diagram of the mixing device body of the present invention;

[0027] Figure 3 For the present invention Figure 2 Enlarged structural diagram at point A;

[0028] Figure 4 For the present invention Figure 2 Enlarged structural diagram at point B;

[0029] Figure 5 This is a schematic diagram of the cooperative structure of the speed reducer, speed reducer plate, and second spring of the present invention;

[0030] Figure 6 This is a top view of the agitator rod of the present invention.

[0031] Figure 7 For the present invention Figure 6Enlarged structural diagram at point C;

[0032] Figure 8 This is a top view cross-sectional structural diagram of the stirring plate of the present invention;

[0033] Figure 9 This is a schematic diagram of the speed reducer of the present invention.

[0034] In the diagram: 1. Mixing device body; 2. Main rotating rod; 3. Fixed ring; 4. Stirring rod; 5. Drive belt; 6. Reducer; 7. Reducer bar; 8. Stirring plate; 9. Secondary rotating rod; 10. Auxiliary support column; 11. Tension spring; 12. Grinding block; 13. Gathering groove; 14. Rotating shaft; 15. First arc-shaped block; 16. Second arc-shaped block; 17. First spring; 18. Hidden groove; 19. Auxiliary limiting rod; 20. Auxiliary cylinder; 21. Reducer plate; 22. Second spring; 23. Auxiliary inclined plane. Detailed Implementation

[0035] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0036] Example 1

[0037] In the current eye patch market, penetration enhancers play a crucial role in improving the efficacy of eye patches. The active ingredients in eye patches must penetrate the complex physiological barriers of the eye, such as the cornea and conjunctiva, to reach the target area and exert effects such as relieving eye fatigue and improving ocular microcirculation. However, existing eye patch penetration enhancer systems have significant shortcomings;

[0038] Existing penetration enhancers often rely on only a few traditional ingredients, such as simple alcohols and natural plant extracts. While these ingredients have some penetration-enhancing effects, their efficiency is far less than that of azone. Taking commonly used ethanol as an example, its penetration-enhancing mechanism is relatively simple, mainly promoting drug penetration by altering the hydration state of the stratum corneum. It has limited effect on the complex and dense barrier structure of the eye, making it difficult to significantly increase the amount of drug entering the eye. Natural plant extract penetration enhancers, such as certain volatile essential oils, while having high safety, have unstable penetration-enhancing effects, with significant differences in penetration performance between different batches, leading to inconsistent quality in eye patch products. This embodiment was invented to address the above problems.

[0039] The present invention provides a technical solution: a penetration enhancer comprising borneol, menthol, 95% ethanol, azone and purified water.

[0040] The borneol is natural borneol;

[0041] There are multiple barriers in the eye tissues, such as the lipid barrier of the corneal epithelium, which can hinder the absorption of drugs. Azone can reduce the barrier function of the cornea and other eye tissues, making it easier for the active ingredients in the eye patch, such as borneol and menthol, to penetrate the cornea, conjunctiva and other tissues into the eye, thereby increasing the bioavailability of the drug in the eye and enhancing the effects of the eye patch in relieving eye fatigue and improving eye microcirculation.

[0042] Some ingredients in eye patches may have poor water or lipid solubility, making it difficult to penetrate eye tissues. Azone has a unique molecular structure and properties, being both lipophilic and hydrophilic, which can help these poorly soluble drugs dissolve and disperse better, promote their penetration of the lipid and water barriers of the eye, and enable the drugs to reach the site of action more effectively.

[0043] Synergistic effect with borneol and menthol: Borneol and menthol have cooling and refreshing effects, while azone can promote their faster and deeper penetration into the eye tissue, enhance their soothing and regulating effects on the optic nerve, and better relieve eye discomfort and reduce eye fatigue.

[0044] Synergistic effect with ethanol: Ethanol can help dissolve azone and other drug components, allowing azone to better exert its permeation-enhancing effect. At the same time, ethanol itself also has a certain effect on promoting drug penetration. The synergy between the two can enhance the overall permeation-enhancing effect.

[0045] Example 2

[0046] After resolving the issues related to the composition of the penetration enhancer, there is still room for improvement in its manufacturing process. In conventional penetration enhancer manufacturing processes, grinding and mixing devices are typically operated separately. From a production efficiency perspective, this separate operation mode means that materials need to be transferred between different devices, increasing operational steps and time costs, and significantly increasing the complexity of the process. For example, during material transfer, not only is additional manpower and time required to complete the conveying, but material loss or external contamination may also occur due to the transfer process.

[0047] Simultaneously, when the mixing device mixes the solution, according to the principles of fluid mechanics, the solution easily forms water vortices within the mixing device. From a hybrid dynamics perspective, the ideal mixing state should be that the components of the solution can be quickly and uniformly dispersed within the device. However, the presence of water vortices severely disrupts this ideal state. The vortices cause the flow velocity of the solution to be too fast in some areas and too slow in others, resulting in uneven mixing. In areas with high flow velocities, the material mixing time is short, making it difficult to fully blend with other components; while in areas with slow flow velocities, local concentrations that are too high or too low are easily formed. This seriously hinders the improvement of the overall mixing efficiency of the solution and is extremely detrimental to the efficient and high-quality production of the penetration enhancer. This embodiment was invented to solve the above problems.

[0048] Based on the above embodiments, the present invention provides a technical solution: a method for manufacturing a penetration enhancer, comprising the following steps:

[0049] S1: Dissolve natural borneol and menthol in 95% ethanol solution;

[0050] S2: Add azone and purified water to the solution, and simultaneously grind and stir it through the mixing device body 1 to prepare a penetration enhancer.

[0051] This requires grinding natural borneol and menthol.

[0052] Please see Figures 1 to 9 The mixing device body 1 has multiple layers of driven components that can rotate and move up and down arranged from top to bottom. Multiple drive belts 5 are fixedly connected between the first and second driven components. Multiple agitators are arranged between the second and third driven components, and multiple agitators are also arranged between the third and fourth driven components. A secondary rotating rod 9 is passed through the second, third, and fourth driven components. The second, third, and fourth driven components and the secondary rotating rod 9 are all fixedly connected. A grinding block 12 that can crush solid materials is fixedly connected to the bottom end of the secondary rotating rod 9. A deceleration component that can reduce the rotation speed of the secondary rotating rod 9 is arranged at the top end of the secondary rotating rod 9.

[0053] Please see Figure 2 A main rotating rod 2 extending into the mixing device body 1 is rotatably connected to the upper surface of the mixing device body 1. The first driven component from top to bottom includes a fixed ring 3 fixedly connected to the bottom end of the main rotating rod 2. Multiple stirring rods 4 are uniformly fixedly connected to the outer circumference of the fixed ring 3, and the structures of the multiple driven components are the same.

[0054] A drive motor is installed directly above the main body 1 of the mixing device. The top of the main rotating rod 2 is firmly connected to the shaft of the drive motor. When the drive motor starts running, it can drive the main rotating rod 2 to rotate synchronously. During the rotation of the main rotating rod 2, it will drive the fixed ring 3 connected to it to rotate together, and the fixed ring 3 will drive the multiple stirring rods 4 on it to rotate synchronously.

[0055] Simultaneously, the upper and lower ends of the drive belt 5 are fixedly connected to the corresponding stirring rods 4. When the main rotating rod 2 rotates under the drive motor, and thus drives the stirring rods 4 to rotate synchronously, the torque is transmitted to the second-layer driven component through the drive belt 5, causing it to start rotating. When the stirring rods 4 initially drive the second-layer driven component through the drive belt 5, since the initial tension on each drive belt 5 is not completely uniform, and the position of the stirring rods 4 changes continuously in the circular motion, according to the theory of force composition and decomposition, multiple drive belts 5 will first undergo irregular twisting, thus driving the second-layer driven component to rotate. As the rotation continues, according to the principle of conservation of angular momentum, the rotational speed of the second-layer driven component will gradually increase and approach the rotational speed of the stirring rods 4. At this time, since the centrifugal force on the drive belt 5 increases with the increase of rotational speed, the middle part of the drive belt 5 will bulge outward due to the centrifugal force, thus forming an arc shape. During rotation, the arc-shaped drive belt 5 applies an upward component force to the second driven component. Based on the principle that forces act in pairs and the principle of force decomposition, the second driven component moves upward while rotating.

[0056] Please see Figures 2 to 3 An auxiliary support column 10 is fixedly connected to the center of the bottom surface of the mixing device body 1, with one end inserted into the auxiliary rotating rod 9. The auxiliary rotating rod 9 can slide up and down on the auxiliary support column 10 and can also rotate. An auxiliary cylinder 20 is rotatably connected to the top of the auxiliary support column 10, and an auxiliary cylinder 20 is also rotatably connected to the inner top surface of the auxiliary rotating rod 9. A tension spring 11 is provided between the two auxiliary cylinders 20.

[0057] By using two auxiliary cylinders 20 and a tension spring 11, when the auxiliary rotating rod 9 rotates, the tension spring 11 is ensured to be unaffected by its rotational movement. During the up-and-down movement of the auxiliary rotating rod 9 along the auxiliary support column 10, the tension spring 11 can be stretched or contracted normally according to the position change of the auxiliary rotating rod 9, ensuring the stable operation of the entire mechanical structure.

[0058] Please see Figures 2 to 5The deceleration component includes a deceleration disc 6 fixedly connected to the top of the auxiliary rotating rod 9. An auxiliary limiting rod 19 is fixedly connected to the top of the auxiliary support column 10. The end of the auxiliary limiting rod 19 furthest from the auxiliary support column 10 passes through a tension spring 11, the auxiliary rotating rod 9, and the deceleration disc 6 in sequence. None of the tension spring 11, the auxiliary rotating rod 9, or the deceleration disc 6 contacts the auxiliary limiting rod 19 (the deceleration disc 6 is fixedly connected to the auxiliary rotating rod 9). Both auxiliary cylinders 20 are also penetrated by the auxiliary limiting rod 19, and there is a gap between them and the auxiliary limiting rod 19. The top of the auxiliary limiting rod 19 is also rotatably connected. Each gearbox 6 has a reduction disc 6, and multiple reduction clips 7 that can be engaged together are provided on the opposite surfaces of the two reduction discs 6. Two limiting mounting slots are formed opposite each other inside the reduction disc 6. Two reduction plates 21, respectively disposed in their corresponding limiting mounting slots, are fixedly connected to the top of an auxiliary limiting rod 19. The end of the reduction plate 21 away from the auxiliary limiting rod 19 abuts against the inner surface of the limiting mounting slot. A second spring 22, with one end disposed on the inner surface of the limiting mounting slot, is fixedly connected to one side of the reduction plate 21. Therefore, when the reduction disc 6 is subjected to external force, it will cause the reduction disc 6 to rotate counterclockwise (from...). Figure 5 (See the image below) Therefore, the second spring 22 will be compressed. When the external force on the speed reduction disc 6 disappears, the speed reduction disc 6 will return to its initial position through the elastic force released by the second spring 22.

[0059] Please see Figure 2 An annular gathering groove 13 is provided at the center of the bottom surface of the mixing device body 1, and the lower surface of the grinding block 12 and the inner bottom surface of the gathering groove 13 are relatively rough.

[0060] When the second-layer driven component moves up and down and rotates, the auxiliary rotating rod 9 enables the third and fourth-layer driven components to move and rotate synchronously. Simultaneously, the grinding block 12 also moves synchronously with the auxiliary rotating rod 9. Due to the presence of the aggregation tank 13 and the tea paradox principle, solid matter in the solution gradually accumulates within the aggregation tank 13. The tea paradox states that when a fluid rotates, particulate matter tends to accumulate near the central axis, and the special structure of the aggregation tank 13 enhances this effect. Therefore, when the grinding block 12 moves upward following the auxiliary rotating rod 9, solid matter naturally enters the aggregation tank 13. When the grinding block 12 falls back to its initial position, it crushes and grinds the solid material in the aggregation tank 13, significantly improving the mixing efficiency of the solution.

[0061] When the secondary rotating rod 9 moves upward via the second driven component, it drives the connected grinding block 12 to rise synchronously. During this process, the reduction gear 6 fixed on the secondary rotating rod 9 gradually approaches the reduction gear 6 fixed on the auxiliary limit rod 19. As the distance between them continues to shorten, the reduction gears 7 on the two reduction gears 6 eventually touch each other. Once the reduction gears 7 touch, the secondary rotating rod 9 will encounter resistance when rotating, which will cause the speed of the secondary rotating rod 9 to drop significantly. At the same time, due to the reduced speed at the bottom end, the drive belt 5 will exhibit an irregular twisting state, and the upward pull generated by centrifugal force will also decrease significantly. At this time, the tension spring 11 will play its role, pulling the secondary rotating rod 9 back to its original position. During the resetting process of the secondary rotating rod 9, the grinding block 12 will perform precise crushing and grinding operations on the solid material gathered in the gathering tank 13, thereby effectively completing the material processing work.

[0062] At the same time, when the stirring rod 4 continues to drive the second driven component to rotate again through the drive belt 5, the above-mentioned motion process will be reproduced;

[0063] When the drive belt 5 drives the multi-layer driven components and the stirring component to rotate synchronously, a vortex gradually forms in the solution within the mixing device body 1. As rotation continues, the rotational speed of the solution increases, gradually approaching the rotational speed of the stirring component. However, when the speed of the auxiliary rotating rod 9 suddenly decreases, the rotational speed of the stirring component also decreases. At this time, the high-speed rotating vortex encounters the slower-rotating stirring component. According to the Karman vortex street principle, when the fluid passes around a non-streamlined object (here referring to the stirring component whose rotational speed suddenly decreases), regular vortices will alternately form on both sides downstream of the object. This phenomenon not only causes a significant change in the fluid flow state but also has a significant impact on the mixing effect of the liquid in the mixing device body 1, thereby disrupting the vortex formed in the solution within the mixing device body 1 and greatly increasing its mixing effect.

[0064] Example 3

[0065] In the above embodiments, although the mixing device body 1 can disrupt the water vortex formed by the internal solution and also crush and grind the solid material, the solution concentration at the bottom of the mixing device body 1 is higher than that at the top due to the dissolution of the solid material in the solution. According to the principle of solution diffusion, the solute diffuses from the high concentration area to the low concentration area, but in the actual mixing process, it takes a certain amount of time to eliminate this concentration difference. When the mixing device body 1 attempts to uniformly mix the internal solution, it often takes a long time to achieve uniform solution concentration due to the influence of the high concentration solution at the bottom. This is mainly because the concentration gradient between the high concentration solution at the bottom and the low concentration solution at the top is large, and the solution diffusion process is relatively slow, which reduces the efficiency of the entire mixing process and is not conducive to quickly and efficiently completing the uniform mixing of the solution. This embodiment is invented to solve the above problems.

[0066] Please see Figures 1 to 9 Based on the above embodiments, the technical solution adopted includes a rotating shaft 14 fixedly connected between two adjacent upper and lower stirring rods 4. Multiple stirring plates 8 that can form inclined surfaces on both sides are arranged from top to bottom on the circumferential surface of the rotating shaft 14. The rotating shaft 14 is only arranged between the third layer of driven components and the second layer of driven components, and between the third layer of driven components and the fourth layer of driven components.

[0067] Please see Figures 1 to 9 Each stirring plate 8 has a second arc-shaped block 16 fixedly connected to its inner circumferential surface. The inner side of the second arc-shaped block 16 is attached to the rotating shaft 14. A first arc-shaped block 15 is fixedly connected to the circumferential surface of the rotating shaft 14 at a position that matches each stirring plate 8. The outer side of the first arc-shaped block 15 is attached to the inner circumferential surface of the stirring plate 8. A hidden groove 18 is provided at one end of the second arc-shaped block 16. A first spring 17, one end of which is set on the first arc-shaped block 15, is fixedly connected to the inner side of the hidden groove 18. The maximum rotation angle of each stirring plate 8 on the rotating shaft 14 gradually increases from bottom to top. Each stirring plate 8 has auxiliary inclined surfaces 23 on opposite sides. Furthermore, when viewed from the top to the bottom of the rotating shaft 14, the distance between the ends of the second arc-shaped block 16 and the first arc-shaped block 15 connected by the first spring 17 on each stirring plate 8 gradually decreases. In other words, on the upper stirring plate 8, the distance between the second arc-shaped block 16 and the first arc-shaped block 15 connected by the first spring 17 is greater than the distance between the corresponding connecting ends on the lower stirring plate 8.

[0068] When the stirring rod 4 drives the rotating shaft 14 to rotate synchronously, the rotating shaft 14 will drive the multiple stirring plates 8 on it to rotate together. Because the maximum rotation angles of the various stirring plates 8 on the rotating shaft 14 differ, when the auxiliary rotating rod 9 rotates counterclockwise (from... Figure 6(From a visual perspective) When the stirring rod 4 rotates, based on Newton's third law in fluid mechanics, namely the law of action and reaction, each stirring plate 8 generates an equal and opposite reaction force from the solution when it agitates the solution. Furthermore, each stirring plate 8 has auxiliary inclined surfaces 23 on opposite sides. Under the action of this reaction force, the stirring plate 8 rotates around the shaft 14. In this way, the stirring plates 8 on each shaft 14 collectively form a structure resembling a "push plate" with two upward-sloping "inclined surfaces".

[0069] From the perspective of force interaction, when the inclined plane of the push plate propels the liquid to rotate, according to the principle of interaction of forces, the inclined plane exerts an upward force on the solution in contact with it. Based on the theory of force decomposition, this upward force can be decomposed into horizontal and vertical components. The horizontal component causes the solution to rotate in a circular motion following the push plate, while the vertical component gives the solution an upward tendency to move while rotating.

[0070] As the push plate continues to rotate, different positions on its inclined surface continuously apply this upward force to the solution. Under the continuous action of multiple forces, the upward movement of the solution accumulates and intensifies. This upward movement caused by the force allows the solution at the bottom of the mixing device body 1 to achieve more thorough exchange and fusion with the solution at the top. According to the mixing efficiency theory, the faster the mass exchange rate between different regions of the solution, the higher the mixing efficiency. Therefore, the push plate composed of the stirring plate 8 greatly improves the mixing efficiency of the solution within the mixing device body 1 through this unique mechanical action, achieving a more efficient solution mixing operation.

[0071] Meanwhile, because the stirring plate 8 has an auxiliary inclined surface 23, it guides the solution to flow in a specific direction when rotating, forming local small eddies. These small eddies can drive the surrounding solution to participate in the flow, so that the mixing effect is not limited to the vicinity of the stirring plate 8, but can be transmitted to a wider area, which helps to expand the mixing range.

[0072] As the stirring plate 8 moves slowly upward, it pulls the surrounding solution upward, creating vertical convection. This phenomenon can be explained by the "boundary layer theory" in fluid dynamics. When the stirring plate 8 moves, the solution layer in direct contact with the plate moves along with it due to viscous forces, thereby pulling the adjacent solution layers, creating a layer-by-layer effect, and ultimately causing the entire solution to flow upward.

[0073] From the perspective of viscous forces, fluids possess viscosity. When the stirring plate 8 moves slowly upward, due to the adhesion between the solution and the surface of the stirring plate 8, the layer of solution in direct contact with the stirring plate 8 will move upward along with the stirring plate 8 under the "pulling" force of viscous forces. This is because the intermolecular forces cause the solution molecules to "adhere" to the surface of the stirring plate 8, thereby being carried upward.

[0074] Meanwhile, as the solution rotates within the mixing device body 1, its rotational speed gradually catches up with the push plate, causing a rotational phenomenon in the torsional angle of each stirring plate 8. This is because the reaction force of the solution on the stirring plate 8 changes with the change in the solution's motion state. When the rotational speed of the solution gradually approaches the rotational speed of the push plate, the force exerted by the solution on the stirring plate 8 decreases, causing a change in the net force on the stirring plate 8. Consequently, its torsional angle cannot reach the maximum rotational angle, resulting in a certain degree of rotation. However, the structure formed by the stirring plates 8 on each rotating shaft 14, resembling a "push plate" with two upward-sloping "inclined surfaces," still exists.

[0075] As the stirring plates 8 rotate, the angle of each plate 8 is continuously adjusted according to the reaction force and motion state of the solution. This rotation ensures that the stirring plates 8 and the solution maintain a constant relative speed, continuously and effectively applying force to the solution and maintaining efficient mixing. Furthermore, the rotation makes the action of the stirring plates 8 on the solution more flexible, resulting in more complex and diverse solution flow paths. This increases the exchange and collision of the solution between different regions, further improving the uniformity and efficiency of mixing. In addition, the rotation can adapt to the constantly changing flow characteristics of the solution during mixing, allowing the mixing device to maintain good mixing performance under different solution concentrations, viscosities, and other conditions.

[0076] When the rotational speed of the secondary rotating rod 9 suddenly decreases, according to the principle of inertia, the solution, which was originally rotating rapidly, will continue to move at high speed and violently impact the other "inclined surface" of the "push plate". According to the momentum theorem, during the collision between the moving solution and the push plate, a downward force will be exerted on the push plate. This force is transmitted sequentially to the secondary rotating rod 9 through rigid connecting components such as the stirring rod 4 and the fixing ring 3, according to the principle of force transmission, and finally acts on the grinding block 12.

[0077] From an energy conversion perspective, the kinetic energy generated by the impact of the solution is converted into the mechanical energy of the grinding blocks 12, significantly enhancing the impact crushing force of the grinding blocks 12 on the solid materials gathered in the aggregation tank 13. According to the grinding principle, a greater impact force can increase the degree and speed of crushing of solid materials, thus improving the grinding effect. A better grinding effect allows the solid materials to be dispersed more finely and uniformly in the solution, accelerating mass exchange and, based on the mixing efficiency theory, significantly improving the mixing efficiency.

[0078] In summary, when using the penetration enhancer and the manufacturing method of the formulation, the operator can add the material into the mixing device body 1 from the top. A switch valve is located at the bottom of the mixing device body 1. After the penetration enhancer mixing process is completed, the operator only needs to turn the switch valve to discharge the material from the mixing device body 1. Simultaneously, the maximum height of the solution within the mixing device body 1 will not exceed the second driven component.

[0079] It should be noted that in the description of this invention, terms such as "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," which indicate direction or positional relationships, are based on the direction or positional relationships shown in the accompanying drawings. These are used merely for ease of description and do not indicate or imply that the device or element must have a specific orientation, or be constructed and operated in a specific orientation; therefore, they should not be construed as limitations on this invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0080] Furthermore, it should be noted that, in the description of this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0081] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A method for manufacturing a penetration enhancer, characterized in that, Includes the following steps: S1: Dissolve natural borneol and menthol in 95% ethanol solution; S2: Add azone and purified water to the solution, and simultaneously grind and stir through the mixing device body (1) to make a penetration enhancer; The mixing device body (1) is provided with multiple layers of driven components that can rotate and move up and down from top to bottom. Multiple drive belts (5) are fixedly connected between the first layer of driven components and the second layer of driven components. Multiple agitators are provided between the second layer of driven components and the third layer of driven components. Multiple agitators are also provided between the third layer of driven components and the fourth layer of driven components. A secondary rotating rod (9) is provided through the second layer of driven components, the third layer of driven components and the fourth layer of driven components. A grinding block (12) capable of crushing solid materials is fixedly connected to the bottom end of the secondary rotating rod (9). A deceleration component capable of reducing the rotation speed of the secondary rotating rod (9) is provided at the top end of the secondary rotating rod (9). The upper surface of the mixing device body (1) is rotatably connected to a main rotating rod (2) that extends into the mixing device body (1) at one end. The first driven component from top to bottom includes a fixed ring (3) fixedly connected to the bottom end of the main rotating rod (2). Multiple stirring rods (4) are uniformly fixedly connected to the outer circumferential surface of the fixed ring (3), and the structures of the multiple driven components are the same. An auxiliary support column (10) with one end inserted into the auxiliary rotating rod (9) is fixedly connected to the center of the bottom surface of the mixing device body (1). An auxiliary cylinder (20) is rotatably connected to the top of the auxiliary support column (10). An auxiliary cylinder (20) is also rotatably connected to the top surface of the auxiliary rotating rod (9). A tension spring (11) is provided between the two auxiliary cylinders (20). The deceleration component includes a deceleration disc (6) fixedly connected to the top of the auxiliary rotating rod (9). An auxiliary limiting rod (19) is fixedly connected to the top of the auxiliary support column (10). The end of the auxiliary limiting rod (19) away from the auxiliary support column (10) passes through the tension spring (11), the auxiliary rotating rod (9), and the deceleration disc (6) in sequence. The top of the auxiliary limiting rod (19) is also rotatably connected to the deceleration disc (6). Multiple deceleration clips (7) that can be snapped together are provided on the opposite surfaces of the two deceleration discs (6). Two limiting installation slots are opened opposite each other in the deceleration disc (6). Two deceleration plates (21) respectively set in the corresponding limiting installation slots are fixedly connected to the top of the auxiliary limiting rod (19). A second spring (22) with one end set on the inner side of the limiting installation slot is fixedly connected to one side of the deceleration plate (21).

2. The method for manufacturing a penetration enhancer according to claim 1, characterized in that: The mixing device body (1) has an annular gathering groove (13) at the center of the bottom surface of the inner surface, and the lower surface of the grinding block (12) and the inner bottom surface of the gathering groove (13) are both rough.

3. The method for manufacturing a penetration enhancer according to claim 2, characterized in that: The stirring component includes a rotating shaft (14) fixedly connected between two adjacent stirring rods (4) on the upper and lower sides. The rotating shaft (14) has multiple stirring plates (8) arranged from top to bottom on its circumference, which can form a stirring plate with inclined surfaces on both sides.

4. The method for manufacturing a penetration enhancer according to claim 3, characterized in that: Each of the stirring plates (8) has a second arc-shaped block (16) fixedly connected to its inner circumferential surface. The inner side of the second arc-shaped block (16) is attached to the rotating shaft (14). A first arc-shaped block (15) is fixedly connected to the rotating shaft (14) at a position that matches each stirring plate (8). The outer side of the first arc-shaped block (15) is attached to the inner circumferential surface of the stirring plate (8). A hidden groove (18) is provided at one end of the second arc-shaped block (16). A first spring (17) is fixedly connected to the inner side of the hidden groove (18) at one end of the first arc-shaped block (15). The maximum rotation angle of each stirring plate (8) located on the rotating shaft (14) gradually increases from bottom to top.

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